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Taras Afonyushkin

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Taras Afonyushkin; Olga Oskolkova; Valery N Bochkov
Permissive role of miR-663 in induction of VEGF and activation of the ATF4 branch of unfolded protein response in endothelial cells by oxidized phospholipids.
Ulrike Grienke; Shu-Hong Guan; De-An Guo; Judit Mihály-Bison; Taras Afonyushkin; Markus Binder; Valery N Bochkov; Chun-ru Cheng; Daniela Schuster; Hermann Stuppner; Gerhard Wolber; Judith M Rollinger
Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum.
Svitlana Demyanets; Christoph Kaun; Kathrin Rychli; Stefan Pfaffenberger; Stefan Kastl; Philipp J Hohensinner; Gersina Rega; Katharina M Katsaros; Taras Afonyushkin; Valery N Bochkov; Matthias Paireder; Ihor Huk; Gerald Maurer; Kurt Huber; Johann Wojta
Oncostatin M-enhanced vascular endothelial growth factor expression in human vascular smooth muscle cells involves PI3K-, p38 MAPK-, Erk1/2- and STAT1/STAT3-dependent pathways and is attenuated by interferon-γ.

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All Publications

2012: Taras Afonyushkin; Olga Oskolkova; Valery N Bochkov
Permissive role of miR-663 in induction of VEGF and activation of the ATF4 branch of unfolded protein response in endothelial cells by oxidized phospholipids.
Atherosclerosis 2012;225(1):50-5.
2011: Ulrike Grienke; Shu-Hong Guan; De-An Guo; Judit Mihály-Bison; Taras Afonyushkin; Markus Binder; Valery N Bochkov; Chun-ru Cheng; Daniela Schuster; Hermann Stuppner; Gerhard Wolber; Judith M Rollinger
Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum.
Bioorganic & medicinal chemistry 2011;19(22):6779-91.
2011: Svitlana Demyanets; Christoph Kaun; Kathrin Rychli; Stefan Pfaffenberger; Stefan Kastl; Philipp J Hohensinner; Gersina Rega; Katharina M Katsaros; Taras Afonyushkin; Valery N Bochkov; Matthias Paireder; Ihor Huk; Gerald Maurer; Kurt Huber; Johann Wojta
Oncostatin M-enhanced vascular endothelial growth factor expression in human vascular smooth muscle cells involves PI3K-, p38 MAPK-, Erk1/2- and STAT1/STAT3-dependent pathways and is attenuated by interferon-γ.
Basic research in cardiology 2011;106(2):217-31.
2011: Taras Afonyushkin; Olga Oskolkova; Bernd R Binder; Valery N Bochkov
Involvement of CK2 in activation of electrophilic genes in endothelial cells by oxidized phospholipids.
Journal of lipid research 2011;52(1):98-103.
2010: Olga Oskolkova; Taras Afonyushkin; Beatrix Preinerstorfer; Wolfgang Bicker; Elena von Schlieffen; Eva Hainzl; Svitlana Demyanets; Gernot Schabbauer; Wolfgang Lindner; Alexandros D Tselepis; Johann Wojta; Bernd R Binder; Valery N Bochkov
Oxidized phospholipids are more potent antagonists of lipopolysaccharide than inducers of inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7706-12.
2010: Emmanouil Kyriakakis; Maria Philippova; manjunath joshi; Dennis Pfaff; Valery N Bochkov; Taras Afonyushkin; Paul Erne; Therese J Resink
T-cadherin attenuates the PERK branch of the unfolded protein response and protects vascular endothelial cells from endoplasmic reticulum stress-induced apoptosis.
Cellular signalling 2010;22(9):1308-16.
2010: Taras Afonyushkin; Olga V Oskolkova; Maria Philippova; Therese J Resink; Paul Erne; Bernd R Binder; Valery N Bochkov
Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(5):1007-13.
2008: Olga Oskolkova; Taras Afonyushkin; Alexander Leitner; Elena von Schlieffen; Peter S Gargalovic; Aldons J Lusis; Bernd R Binder; Valery N Bochkov
ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response.
Blood 2008;112(2):330-9.
2008: Henna-Kaisa Jyrkkänen; Emilia Kansanen; Matias Inkala; Annukka M Kivelä; Hanna Hurttila; Suvi E Heinonen; Gundars Goldsteins; Suvi Jauhiainen; Satu Tiainen; Harri Makkonen; Olga Oskolkova; Taras Afonyushkin; Jari Koistinaho; Masayuki Yamamoto; Valery N Bochkov; Seppo Ylä-Herttuala; Anna-Liisa Levonen
Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo.
Circulation research 2008;103(1):e1-9.
2008: Maria Philippova; Danila Ivanov; manjunath joshi; Emmanouil Kyriakakis; Katharina Rupp; Taras Afonyushkin; Valery Bochkov; Paul Erne; Therese J Resink
Identification of proteins associating with glycosylphosphatidylinositol- anchored T-cadherin on the surface of vascular endothelial cells: role for Grp78/BiP in T-cadherin-dependent cell survival.
Molecular and cellular biology 2008;28(12):4004-17.
2008: A Resch; Taras Afonyushkin; Tania B Lombo; Kenneth J McDowall; Udo Bläsi; Vladimir R Kaberdin
Translational activation by the noncoding RNA DsrA involves alternative RNase III processing in the rpoS 5'-leader.
RNA (New York, N.Y.) 2008;14(3):454-9.
2008: Stefan Kastl; Walter S Speidl; Christoph Kaun; Katharina M Katsaros; Gersina Rega; Taras Afonyushkin; Valery N Bochkov; Peter Valent; Afshin Assadian; Georg W Hagmueller; Martina Hoeth; Rainer de Martin; Yongsheng Ma; Gerald Maurer; Kurt Huber; Johann Wojta
In human macrophages the complement component C5a induces the expression of oncostatin M via AP-1 activation.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(3):498-503.
2007: Svitlana Demyanets; Christoph Kaun; Kathrin Rychli; Gersina Rega; Stefan Pfaffenberger; Taras Afonyushkin; Valery N Bochkov; Gerald Maurer; Kurt Huber; Johann Wojta
The inflammatory cytokine oncostatin M induces PAI-1 in human vascular smooth muscle cells in vitro via PI 3-kinase and ERK1/2-dependent pathways.
American journal of physiology. Heart and circulatory physiology 2007;293(3):H1962-8.
2006: Valery N Bochkov; Maria Philippova; Olga Oskolkova; Alexandra Kadl; Alexander Furnkranz; Erduan Karabeg; Taras Afonyushkin; Florian Gruber; Johannes M Breuss; Alexander Minchenko; Diana Mechtcheriakova; Philipp J Hohensinner; Kathrin Rychli; Johann Wojta; Therese J Resink; Paul Erne; Bernd R Binder; Norbert Leitinger
Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions.
Circulation research 2006;99(8):900-8.
2005: Taras Afonyushkin; Branislav Vecerek; Isabella Moll; Udo Bläsi; Vladimir R Kaberdin
Both RNase E and RNase III control the stability of sodB mRNA upon translational inhibition by the small regulatory RNA RyhB.
Nucleic acids research 2005;33(5):1678-89.
2004: Elisabeth Sonnleitner; Johanna Napetschnig; Taras Afonyushkin; Karin Ecker; Branislav Vecerek; Isabella Moll; Vladimir R Kaberdin; Udo Bläsi
Functional effects of variants of the RNA chaperone Hfq.
Biochemical and biophysical research communications 2004;323(3):1017-23.
2003: Taras Afonyushkin; Isabella Moll; Udo Bläsi; Vladimir R Kaberdin
Temperature-dependent stability and translation of Escherichia coli ompA mRNA.
Biochemical and biophysical research communications 2003;311(3):604-9.
2003: Branislav Vecerek; Isabella Moll; Taras Afonyushkin; Vladimir R Kaberdin; Udo Bläsi
Interaction of the RNA chaperone Hfq with mRNAs: direct and indirect roles of Hfq in iron metabolism of Escherichia coli.
Molecular microbiology 2003;50(3):897-909.
2003: Isabella Moll; Taras Afonyushkin; Oresta Vytvytska; Vladimir R Kaberdin; Udo Bläsi
Coincident Hfq binding and RNase E cleavage sites on mRNA and small regulatory RNAs.
RNA (New York, N.Y.) 2003;9(11):1308-14.