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Hiroshi Mori

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
14
Shoji, Shin'ichi
14
Tomiyama, Takami
12
Tamaoka, Akira
10
Shirasawa, Takuji
10
Akiyama, Haruhiko
10
Ihara, Yasuo
10
Ishii, Kazuhiro
9
Ikeda, K
9
Usami, Mihoko
7
takuma, hiroshi
7
Kametani, Fuyuki
6
Gearing, Marla
6
Haratake, Mamoru
6
Mirra, Suzanne
6
Nakayama, Morio

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Publications

TOP 3
Bullmann Torsten; Holzer Max; Mori Hiroshi; Arendt Thomas
Pattern of tau isoforms expression during development in vivo.
Ito Kazuhiro; Ishibashi Ken-ichi; Tomiyama Takami; Umeda Tomohiro; Yamamoto Kei-ichi; Kitajima Erika; Idomoto Toshiki; Nagatomo Toshie; Mori Hiroshi
Oligomeric amyloid beta-protein as a therapeutic target in Alzheimer's disease: its significance based on its distinct localization and the occurrence of a familial variant form.
Nishitsuji Kazuchika; Tomiyama Takami; Ishibashi Kenichi; Ito Kazuhiro; Teraoka Rie; Lambert Mary P; Klein William L; Mori Hiroshi
The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells.

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All Publications

2009: Bullmann Torsten; Holzer Max; Mori Hiroshi; Arendt Thomas
Pattern of tau isoforms expression during development in vivo.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2009;27(6):591-7.
2009: Ito Kazuhiro; Ishibashi Ken-ichi; Tomiyama Takami; Umeda Tomohiro; Yamamoto Kei-ichi; Kitajima Erika; Idomoto Toshiki; Nagatomo Toshie; Mori Hiroshi
Oligomeric amyloid beta-protein as a therapeutic target in Alzheimer's disease: its significance based on its distinct localization and the occurrence of a familial variant form.
Current Alzheimer research 2009;6(2):132-6.
2009: Nishitsuji Kazuchika; Tomiyama Takami; Ishibashi Kenichi; Ito Kazuhiro; Teraoka Rie; Lambert Mary P; Klein William L; Mori Hiroshi
The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells.
The American journal of pathology 2009;174(3):957-69.
2008: Takuma Hiroshi; Teraoka Rie; Mori Hiroshi; Tomiyama Takami
Amyloid-beta E22Delta variant induces synaptic alteration in mouse hippocampal slices.
Neuroreport 2008;19(6):615-9.
2008: Tomiyama Takami; Nagata Tetsu; Shimada Hiroyuki; Teraoka Rie; Fukushima Akiko; Kanemitsu Hyoue; Takuma Hiroshi; Kuwano Ryozo; Imagawa Masaki; Ataka Suzuka; Wada Yasuhiro; Yoshioka Eito; Nishizaki Tomoyuki; Watanabe Yasuyoshi; Mori Hiroshi
A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.
Annals of neurology 2008;63(3):377-87.
2007: Ono Masahiro; Haratake Mamoru; Mori Hiroshi; Nakayama Morio
Novel chalcones as probes for in vivo imaging of beta-amyloid plaques in Alzheimer's brains.
Bioorganic & medicinal chemistry 2007;15(21):6802-9.
2007: Maeda Jun; Ji Bin; Irie Toshiaki; Tomiyama Takami; Maruyama Masahiro; Okauchi Takashi; Staufenbiel Matthias; Iwata Nobuhisa; Ono Maiko; Saido Takaomi C; Suzuki Kazutoshi; Mori Hiroshi; Higuchi Makoto; Suhara Tetsuya
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(41):10957-68.
2007: Ono Masahiro; Hori Miyuki; Haratake Mamoru; Tomiyama Takami; Mori Hiroshi; Nakayama Morio
Structure-activity relationship of chalcones and related derivatives as ligands for detecting of beta-amyloid plaques in the brain.
Bioorganic & medicinal chemistry 2007;15(19):6388-96.
2007: Nishitsuji Kazuchika; Tomiyama Takami; Ishibashi Kenichi; Kametani Fuyuki; Ozawa Kazuharu; Okada Ryota; Maat-Schieman Marion L; Roos Raymund A C; Iwai Kazuhiro; Mori Hiroshi
Cerebral vascular accumulation of Dutch-type Abeta42, but not wild-type Abeta42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type.
Journal of neuroscience research 2007;85(13):2917-23.
2007: Ono Masahiro; Maya Yoshifumi; Haratake Mamoru; Ito Kazuhiro; Mori Hiroshi; Nakayama Morio
Aurones serve as probes of beta-amyloid plaques in Alzheimer's disease.
Biochemical and biophysical research communications 2007;361(1):116-21.
2007: Matsuyama Shogo; Teraoka Rie; Mori Hiroshi; Tomiyama Takami
Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice.
Neuroreport 2007;18(10):1083-7.
2007: Sennvik Kristina; Boekhoorn Karin; Lasrado Reena; Terwel Dick; Verhaeghe Steven; Korr Hubert; Schmitz Christoph; Tomiyama Takami; Mori Hiroshi; Krugers Harm; Joels Marian; Ramakers Ger J A; Lucassen Paul J; Van Leuven Fred
Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(9):2149-61.
2007: Hasegawa Masato; Arai Tetsuaki; Akiyama Haruhiko; Nonaka Takashi; Mori Hiroshi; Hashimoto Tomoyo; Yamazaki Mineo; Oyanagi Kiyomitsu
TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.
Brain : a journal of neurology 2007;130(Pt 5):1386-94.
2007: Bullmann Torsten; de Silva Rohan; Holzer Max; Mori Hiroshi; Arendt Thomas
Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus.
Hippocampus 2007;17(2):98-102.
2006: Arai Tetsuaki; Hasegawa Masato; Akiyama Haruhiko; Ikeda Kenji; Nonaka Takashi; Mori Hiroshi; Mann David; Tsuchiya Kuniaki; Yoshida Mari; Hashizume Yoshio; Oda Tatsuro
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Biochemical and biophysical research communications 2006;351(3):602-11.
2006: Mori Hiroshi; Ito Kazuhiro
[Ubiquitin in Alzheimer's disease]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2006;51(10 Suppl):1408-12.
2006: Ishibashi Ken-Ichi; Tomiyama Takami; Nishitsuji Kazuchika; Hara Mitsuhiro; Mori Hiroshi
Absence of synaptophysin near cortical neurons containing oligomer Abeta in Alzheimer's disease brain.
Journal of neuroscience research 2006;84(3):632-6.
2006: Ono Masahiro; Kawashima Hidekazu; Nonaka Akemi; Kawai Tomoki; Haratake Mamoru; Mori Hiroshi; Kung Mei-Ping; Kung Hank F; Saji Hideo; Nakayama Morio
Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains.
Journal of medicinal chemistry 2006;49(9):2725-30.
2006: Boekhoorn Karin; Terwel Dick; Biemans Barbara; Borghgraef Peter; Wiegert Olof; Ramakers Ger J A; de Vos Koos; Krugers Harm; Tomiyama Takami; Mori Hiroshi; Joels Marian; van Leuven Fred; Lucassen Paul J
Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(13):3514-23.
2005: Ono Masahiro; Yoshida Naoko; Ishibashi Kenichi; Haratake Mamoru; Arano Yasushi; Mori Hiroshi; Nakayama Morio
Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain.
Journal of medicinal chemistry 2005;48(23):7253-60.
2005: Taniguchi Taizo; Doe Nobutaka; Matsuyama Shogo; Kitamura Yoshihisa; Mori Hiroshi; Saito Naoaki; Tanaka Chikako
Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation.
FEBS letters 2005;579(25):5704-12.
2005: Lippa Sara M; Lippa Carol F; Mori Hiroshi
Alpha-Synuclein aggregation in pathological aging and Alzheimer's disease: the impact of beta-amyloid plaque level.
American journal of Alzheimer's disease and other dementias 2005;20(5):315-8.
2005: Suga Kei; Saito Ayako; Tomiyama Takami; Mori Hiroshi; Akagawa Kimio
Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells.
Journal of neurochemistry 2005;94(2):425-39.
2005: Ishibashi Kenichi; Murata Takaho; Miki Yukio; Hara Mitsuhiro; Mori Hiroshi
[Japanese CADASIL case with limited dementia who had the Notch 3 R141C mutation]
No to shinkei = Brain and nerve 2005;57(5):415-8.
2005: Ono Masahiro; Haratake Mamoru; Nakayama Morio; Kaneko Yoshikazu; Kawabata Koichi; Mori Hiroshi; Kung Mei-Ping; Kung Hank F
Synthesis and biological evaluation of (E)-3-styrylpyridine derivatives as amyloid imaging agents for Alzheimer's disease.
Nuclear medicine and biology 2005;32(4):329-35.
2005: Yamashita Takenari; Tomiyama Takami; Li Qiang; Numata Hideharu; Mori Hiroshi
Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10.
FEBS letters 2005;579(1):241-4.
2004: Ataka Suzuka; Tomiyama Takami; Takuma Hiroshi; Yamashita Takenari; Shimada Hiroyuki; Tsutada Tsuyoshi; Kawabata Koichi; Mori Hiroshi; Miki Takami
A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis.
Archives of neurology 2004;61(11):1773-6.
2004: Suga Kei; Tomiyama Takami; Mori Hiroshi; Akagawa Kimio
Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production.
The Biochemical journal 2004;381(Pt 3):619-28.
2004: Kosaka Satoru; Takuma Hiroshi; Tomiyama Takami; Mori Hiroshi
The distributions of tau short and long isoforms fused with EGFP in cultured cells.
Osaka city medical journal 2004;50(1):19-27.
2004: Mori Hiroshi; Yamashita Takenari; Kosaka Satoru
[Tauopathy]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 4():214-9.
2004: Kametani Fuyuki; Usami Mihoko; Tanaka Kikuko; Kume Hideaki; Mori Hiroshi
Mutant presenilin (A260V) affects Rab8 in PC12D cell.
Neurochemistry international 2004;44(5):313-20.
2004: Takuma Hiroshi; Tomiyama Takami; Kuida Keisuke; Mori Hiroshi
Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo.
Journal of neuropathology and experimental neurology 2004;63(3):255-61.
2003: Kanemitsu Hyoe; Tomiyama Takami; Mori Hiroshi
Human neprilysin is capable of degrading amyloid beta peptide not only in the monomeric form but also the pathological oligomeric form.
Neuroscience letters 2003;350(2):113-6.
2003: Uchihara Toshiki; Nakamura Ayako; Nakayama Hiroshi; Arima Kunimasa; Ishizuka Norio; Mori Hiroshi; Mizushima Setsuo
Triple immunofluorolabeling with two rabbit polyclonal antibodies and a mouse monoclonal antibody allowing three-dimensional analysis of cotton wool plaques in Alzheimer disease.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003;51(9):1201-6.
2003: Hashimoto Yusuke; Tomiyama Takami; Yamano Yoshiki; Mori Hiroshi
Mutation (D472Y) in the type 3 repeat domain of cartilage oligomeric matrix protein affects its early vesicle trafficking in endoplasmic reticulum and induces apoptosis.
The American journal of pathology 2003;163(1):101-10.
2003: Takuma Hiroshi; Arawaka Shigeki; Mori Hiroshi
Isoforms changes of tau protein during development in various species.
Brain research. Developmental brain research 2003;142(2):121-7.
2003: Mori Hiroshi; Tomiyama Takami; Maeda Naoki; Ozawa Kazuharu; Wakasa KenIchi
Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome.
Neuropathology : official journal of the Japanese Society of Neuropathology 2003;23(1):51-6.
2003: Hébert Sébastien S; Godin Chantal; Tomiyama Takami; Mori Hiroshi; Lévesque Georges
Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes.
Biochemical and biophysical research communications 2003;301(1):119-26.
2002: Ozawa K; Tomiyama T; Maat-Schieman M L; Roos R A; Mori H
Enhanced Abeta40 deposition was associated with increased Abeta42-43 in cerebral vasculature with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D).
Annals of the New York Academy of Sciences 2002;977():149-54.
2002: Ishii Kazuhiro; Klunk William E; Arawaka Shigeki; Debnath Manik L; Furiya Yoshiko; Sahara Naruhiko; Shoji Shin'ichi; Tamaoka Akira; Pettegrew Jay W; Mori Hiroshi
Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice.
Neuroscience letters 2002;333(1):5-8.
2002: Yuasa Shigeki; Nakajima Mitsunari; Aizawa Hidenori; Sahara Naruhiko; Koizumi Ken-Ichi; Sakai Tsuyoshi; Usami Mihoko; Kobayashi Shin-Ichiro; Kuroyanagi Hidehito; Mori Hiroshi; Koseki Haruhiko; Shirasawa Takuji
Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice.
Journal of neuroscience research 2002;70(3):501-13.
2002: Iwanaga Yasuhiro; Suzuki Yasuyuki; Okada Yoshikatsu; Mori Hiroshi; Matsumoto Ippei; Mitsutsuji Masaaki; Tanioka Yasuki; Fujino Yasuhiro; Tominaga Masahiro; Ku Yonson; Kuroda Yoshikazu
Ultrastructural analyses of pancreatic grafts preserved by the two-layer cold-storage method and by simple cold storage in University of Wisconsin solution.
Transplant international : official journal of the European Society for Organ Transplantation 2002;15(8):425-30.
2002: Busciglio Jorge; Pelsman Alejandra; Wong Caine; Pigino Gustavo; Yuan Menglan; Mori Hiroshi; Yankner Bruce A
Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome.
Neuron 2002;33(5):677-88.
2001: Mori H
[Visualization of tau isoforms by splicing-site specific antibodies]
Rinsho shinkeigaku = Clinical neurology 2001;41(12):1104-6.
2001: Kosaka S; Takuma H; Mori H
[Tauopathy]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 2001;38(5):600-4.
2001: Kametani F; Tanaka K; Usami M; Maruyama K; Mori H
Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the processing of Alzheimer's amyloid precursor protein in PC12D cells.
Journal of the neurological sciences 2001;188(1-2):27-31.
2001: Park I H; Jung M W; Mori H; Mook-Jung I
Zinc enhances synthesis of presenilin 1 in mouse primary cortical culture.
Biochemical and biophysical research communications 2001;285(3):680-8.
2001: Ishii K; Lippa C; Tomiyama T; Miyatake F; Ozawa K; Tamaoka A; Hasegawa T; Fraser P E; Shoji S; Nee L E; Pollen D A; St George-Hyslop P H; Ii K; Ohtake T; Kalaria R N; Rossor M N; Lantos P L; Cairns N J; Farrer L A; Mori H
Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition.
Neurobiology of aging 2001;22(3):367-76.
2001: Mori H; Sakakibara S; Imai T; Nakamura Y; Iijima T; Suzuki A; Yuasa Y; Takeda M; Okano H
Expression of mouse igf2 mRNA-binding protein 3 and its implications for the developing central nervous system.
Journal of neuroscience research 2001;64(2):132-43.
2001: Takahashi K; Kamiya K; Urase K; Suga M; Takizawa T; Mori H; Yoshikawa Y; Ichimura K; Kuida K; Momoi T
Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing loss.
Brain research 2001;894(2):359-67.
2001: Pigino G; Pelsman A; Mori H; Busciglio J
Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(3):834-42.
2000: Cavani S; Tamaoka A; Moretti A; Marinelli L; Angelini G; Di Stefano S; Piombo G; Cazzulo V; Matsuno S; Shoji S; Furiya Y; Zaccheo D; Dagna-Bricarelli F; Tabaton M; Mori H
Plasma levels of amyloid beta 40 and 42 are independent from ApoE genotype and mental retardation in Down syndrome.
American journal of medical genetics 2000;95(3):224-8.
2000: Nakamura Y; Hashimoto R; Amano M; Nagata K; Matsumoto N; Goto H; Fukusho E; Mori H; Kashiwagi Y; Kudo T; Inagaki M; Takeda M
Localized phosphorylation of vimentin by rho-kinase in neuroblastoma N2a cells.
Genes to cells : devoted to molecular & cellular mechanisms 2000;5(10):823-37.
2000: Mori H
Untangling Alzheimer's disease from fibrous lesions of neurofibrillary tangles and senile plaques.
Neuropathology : official journal of the Japanese Society of Neuropathology 2000;20 Suppl():S55-60.
2000: Shimizu T; Watanabe A; Ogawara M; Mori H; Shirasawa T
Isoaspartate formation and neurodegeneration in Alzheimer's disease.
Archives of biochemistry and biophysics 2000;381(2):225-34.
2000: Tamaoka A; Miyatake F; Matsuno S; Ishii K; Nagase S; Sahara N; Ono S; Mori H; Wakabayashi K; Tsuji S; Takahashi H; Shoji S
Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease.
Neurology 2000;54(12):2319-21.
2000: Sahara N; Tomiyama T; Mori H
Missense point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: a novel action of R406W mutation.
Journal of neuroscience research 2000;60(3):380-7.
2000: Kudo T; Mima T; Hashimoto R; Nakao K; Morihara T; Tanimukai H; Tsujio I; Koike Y; Tagami S; Mori H; Nakamura Y; Tanaka T; Mori K; Takeda M
Tau protein is a potential biological marker for normal pressure hydrocephalus.
Psychiatry and clinical neurosciences 2000;54(2):199-202.
2000: Maruyama K; Usami M; Kametani F; Tomita T; Iwatsubo T; Saido T C; Mori H; Ishiura S
Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain.
International journal of molecular medicine 2000;5(3):269-73.
2000: Lippa C F; Schmidt M L; Nee L E; Bird T; Nochlin D; Hulette C; Mori H; Lee V M; Trojanowski J Q
AMY plaques in familial AD: comparison with sporadic Alzheimer's disease.
Neurology 2000;54(1):100-4.
2000: Maclean C J; Baker H F; Ridley R M; Mori H
Naturally occurring and experimentally induced beta-amyloid deposits in the brains of marmosets (Callithrix jacchus).
Journal of neural transmission (Vienna, Austria : 1996) 2000;107(7):799-814.
1999: Tomiyama T; Corder E H; Mori H
Molecular pathogenesis of apolipoprotein E-mediated amyloidosis in late-onset Alzheimer's disease.
Cellular and molecular life sciences : CMLS 1999;56(3-4):268-79.
1999: Wolf D S; Gearing M; Snowdon D A; Mori H; Markesbery W R; Mirra S S
Progression of regional neuropathology in Alzheimer disease and normal elderly: findings from the Nun study.
Alzheimer disease and associated disorders 1999;13(4):226-31.
1999: Lippa C F; Ozawa K; Mann D M; Ishii K; Smith T W; Arawaka S; Mori H
Deposition of beta-amyloid subtypes 40 and 42 differentiates dementia with Lewy bodies from Alzheimer disease.
Archives of neurology 1999;56(9):1111-8.
1999: Sekijima Y; Kametani F; Tanaka K; Okochi M; Usami M; Mori H; Tokuda T; Ikeda S
Presenilin-1 exists in the axoplasm fraction in the brains of aged Down's syndrome subjects and non-demented individuals.
Neuroscience letters 1999;267(2):121-4.
1999: Arawaka S; Usami M; Sahara N; Schellenberg G D; Lee G; Mori H
The tau mutation (val337met) disrupts cytoskeletal networks of microtubules.
Neuroreport 1999;10(5):993-7.
1999: Fukuda H; Shimizu T; Nakajima M; Mori H; Shirasawa T
Synthesis, aggregation, and neurotoxicity of the Alzheimer's Abeta1-42 amyloid peptide and its isoaspartyl isomers.
Bioorganic & medicinal chemistry letters 1999;9(7):953-6.
1999: Arai T; Akiyama H; Ikeda K; Kondo H; Mori H
Immunohistochemical localization of amyloid beta-protein with amino-terminal aspartate in the cerebral cortex of patients with Alzheimer's disease.
Brain research 1999;823(1-2):202-6.
1999: Akiyama H; Mori H; Saido T; Kondo H; Ikeda K; McGeer P L
Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease.
Glia 1999;25(4):324-31.
1999: Arai T; Ikeda K; Akiyama H; Haga C; Usami M; Sahara N; Iritani S; Mori H
A high incidence of apolipoprotein E epsilon4 allele in middle-aged non-demented subjects with cerebral amyloid beta protein deposits.
Acta neuropathologica 1999;97(1):82-4.
1999: Hong C S; Caromile L; Nomata Y; Mori H; Bredesen D E; Koo E H
Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(2):637-43.
1998: Lippa C F; Nee L E; Mori H; St George-Hyslop P
Abeta-42 deposition precedes other changes in PS-1 Alzheimer's disease.
Lancet 1998;352(9134):1117-8.
1998: Komori T; Arai N; Oda M; Nakayama H; Mori H; Yagishita S; Takahashi T; Amano N; Murayama S; Murakami S; Shibata N; Kobayashi M; Sasaki S; Iwata M
Astrocytic plaques and tufts of abnormal fibers do not coexist in corticobasal degeneration and progressive supranuclear palsy.
Acta neuropathologica 1998;96(4):401-8.
1998: Corder E H; Lannfelt L; Bogdanovic N; Fratiglioni L; Mori H
The role of APOE polymorphisms in late-onset dementias.
Cellular and molecular life sciences : CMLS 1998;54(9):928-34.
1998: Arawaka S; Saito Y; Murayama S; Mori H
Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein.
Neurology 1998;51(3):887-9.
1998: Tamaoka A; Fraser P E; Ishii K; Sahara N; Ozawa K; Ikeda M; Saunders A M; Komatsuzaki Y; Sherrington R; Levesque G; Yu G; Rogaeva E; Shoji S; Nee L E; Pollen D A; Hendriks L; Martin J J; Van Broeckhoven C; Roses A D; Farrer L A; St George-Hyslop P H; Mori H
Amyloid-beta-protein isoforms in brain of subjects with PS1-linked, beta APP-linked and sporadic Alzheimer disease.
Brain research. Molecular brain research 1998;56(1-2):178-85.
1998: Zhang J; Kang D E; Xia W; Okochi M; Mori H; Selkoe D J; Koo E H
Subcellular distribution and turnover of presenilins in transfected cells.
The Journal of biological chemistry 1998;273(20):12436-42.
1998: Yamamoto A; Takagi H; Kitamura D; Tatsuoka H; Nakano H; Kawano H; Kuroyanagi H; Yahagi Y; Kobayashi S; Koizumi K; Sakai T; Saito K; Chiba T; Kawamura K; Suzuki K; Watanabe T; Mori H; Shirasawa T
Deficiency in protein L-isoaspartyl methyltransferase results in a fatal progressive epilepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(6):2063-74.
1998: Okochi M; Sahara N; Kametani F; Usami M; Arai T; Tanaka K; Ishii K; Yamamoto A; Mori H
Presenilin 1 cleavage is a universal event in human organs.
Neurobiology of aging 1998;19(1 Suppl):S3-10.
1998: Mitani K; Furiya Y; Uchihara T; Ishii K; Yamanouchi H; Mizusawa H; Mori H
Increased CSF tau protein in corticobasal degeneration.
Journal of neurology 1998;245(1):44-6.
1997: Akiyama H; Mori H; Sahara N; Kondo H; Ikeda K; Nishimura T; Oda T; McGeer P L
Variable deposition of amyloid beta-protein (A beta) with the carboxy-terminus that ends at residue valine40 (A beta 40) in the cerebral cortex of patients with Alzheimer's disease: a double-labeling immunohistochemical study with antibodies specific for A beta 40 and the A beta that ends at residues alanine42/threonine43 (A beta 42).
Neurochemical research 1997;22(12):1499-506.
1997: Okochi M; Ishii K; Usami M; Sahara N; Kametani F; Tanaka K; Fraser P E; Ikeda M; Saunders A M; Hendriks L; Shoji S I; Nee L E; Martin J J; Van Broeckhoven C; St George-Hyslop P H; Roses A D; Mori H
Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations.
FEBS letters 1997;418(1-2):162-6.
1997: Sawamura N; Tamaoka A; Shoji S; Koo E H; Walker L C; Mori H
Characterization of amyloid beta protein species in cerebral amyloid angiopathy of a squirrel monkey by immunocytochemistry and enzyme-linked immunosorbent assay.
Brain research 1997;764(1-2):225-9.
1997: Mori H
The biological significance of neuropathological lesions in Alzheimer's disease.
Neurobiology of aging 1997;18(4):379-82; discussion 389-92.
1997: Ishii K; Ii K; Hasegawa T; Shoji S; Doi A; Mori H
Increased A beta 42(43)-plaque deposition in early-onset familial Alzheimer's disease brains with the deletion of exon 9 and the missense point mutation (H163R) in the PS-1 gene.
Neuroscience letters 1997;228(1):17-20.
1997: Ikeda K; Akiyama H; Arai T; Sahara N; Mori H; Usami M; Sakata M; Mizutani T; Wakabayashi K; Takahashi H
A subset of senile dementia with high incidence of the apolipoprotein E epsilon2 allele.
Annals of neurology 1997;41(5):693-5.
1997: Tamaoka A; Sawamura N; Fukushima T; Shoji S; Matsubara E; Shoji M; Hirai S; Furiya Y; Endoh R; Mori H
Amyloid beta protein 42(43) in cerebrospinal fluid of patients with Alzheimer's disease.
Journal of the neurological sciences 1997;148(1):41-5.
1997: Gearing M; Tigges J; Mori H; Mirra S S
beta-Amyloid (A beta) deposition in the brains of aged orangutans.
Neurobiology of aging 1997;18(2):139-46.
1997: Nishimura T; Ikeda K; Akiyama H; Arai T; Kondo H; Okochi M; Furiya Y; Mori H; Oda T; Kato M; Iseki E
Glial tau-positive structures lack the sequence encoded by exon 3 of the tau protein gene.
Neuroscience letters 1997;224(3):169-72.
1997: Ishii K; Tamaoka A; Mizusawa H; Shoji S; Ohtake T; Fraser P E; Takahashi H; Tsuji S; Gearing M; Mizutani T; Yamada S; Kato M; St George-Hyslop P H; Mirra S S; Mori H
Abeta1-40 but not Abeta1-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimer's disease.
Brain research 1997;748(1-2):250-2.
1996: Gearing M; Tigges J; Mori H; Mirra S S
A beta40 is a major form of beta-amyloid in nonhuman primates.
Neurobiology of aging 1996;17(6):903-8.
1996: Akiyama H; Kondo H; Mori H; Kametani F; Nishimura T; Ikeda K; Kato M; McGeer P L
The amino-terminally truncated forms of amyloid beta-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients.
Neuroscience letters 1996;219(2):115-8.
1996: Tomoda T; Shirasawa T; Yahagi Y I; Ishii K; Takagi H; Furiya Y; Arai K I; Mori H; Muramatsu M A
Transforming growth factor-beta is a survival factor for neonate cortical neurons: coincident expression of type I receptors in developing cerebral cortices.
Developmental biology 1996;179(1):79-90.
1996: Yamamoto A; Sahara N; Usami M; Okochi M; Kondo T; Kametani F; Tanaka K; Yahagi Y; Shirasawa T; Itoyama Y; Mori H
Abnormal gel-electrophoretic behavior of presenilin 1 and it's fragment.
Biochemical and biophysical research communications 1996;226(2):536-41.
1996: Takano T; Yamanouchi Y; Sahara N; Shirasawa T; Mori H
Assignment of Alzheimer's presenilin-1 (PS-1) gene to 14q24.3 by fluorescence in situ hybridization.
Neuroscience letters 1996;214(1):69-71.
1996: Kondo T; Shirasawa T; Itoyama Y; Mori H
Embryonic genes expressed in Alzheimer's disease brains.
Neuroscience letters 1996;209(3):157-60.
1996: Tamaoka A; Endoh R; Shoji S; Takahashi H; Hirokawa K; Teplow D B; Selkoe D J; Mori H
Antibodies to amyloid beta protein (A beta) crossreact with glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
Neurobiology of aging 1996;17(3):405-14.
1996: Ogeng'o J A; Cohen D L; Sayi J G; Matuja W B; Chande H M; Kitinya J N; Kimani J K; Friedland R P; Mori H; Kalaria R N
Cerebral amyloid beta protein deposits and other Alzheimer lesions in non-demented elderly east Africans.
Brain pathology (Zurich, Switzerland) 1996;6(2):101-7.
1996: Akiyama H; Schwab C; Kondo H; Mori H; Kametani F; Ikeda K; McGeer P L
Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of beta-amyloid protein.
Neuroscience letters 1996;206(2-3):169-72.
1996: Gearing M; Mori H; Mirra S S
Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease.
Annals of neurology 1996;39(3):395-9.
1996: Sahara N; Yahagi Y; Takagi H; Kondo T; Okochi M; Usami M; Shirasawa T; Mori H
Identification and characterization of presenilin I-467, I-463 and I-374.
FEBS letters 1996;381(1-2):7-11.
1995: Nakamura S; Tamaoka A; Sawamura N; Shoji S; Nakayama H; Ono F; Sakakibara I; Yoshikawa Y; Mori H; Goto N
Carboxyl end-specific monoclonal antibodies to amyloid beta protein (A beta) subtypes (A beta 40 and A beta 42(43)) differentiate A beta in senile plaques and amyloid angiopathy in brains of aged cynomolgus monkeys.
Neuroscience letters 1995;201(2):151-4.
1995: Gearing M; Schneider J A; Robbins R S; Hollister R D; Mori H; Games D; Hyman B T; Mirra S S
Regional variation in the distribution of apolipoprotein E and A beta in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1995;54(6):833-41.
1995: Kondo T; Mochizuki H; Ueda G; Mori H; Shirai T; Imai H; Mizuno Y
[A 51-year-old man with early onset parkinsonism]
No to shinkei = Brain and nerve 1995;47(6):603-12.
1995: Harigaya Y; Shoji M; Kawarabayashi T; Kanai M; Nakamura T; Iizuka T; Igeta Y; Saido T C; Sahara N; Mori H
Modified amyloid beta protein ending at 42 or 40 with different solubility accumulates in the brain of Alzheimer's disease.
Biochemical and biophysical research communications 1995;211(3):1015-22.
1995: Tamaoka A; Sawamura N; Odaka A; Suzuki N; Mizusawa H; Shoji S; Mori H
Amyloid beta protein 1-42/43 (A beta 1-42/43) in cerebellar diffuse plaques: enzyme-linked immunosorbent assay and immunocytochemical study.
Brain research 1995;679(1):151-6.
1995: Tamaoka A; Mizusawa H; Mori H; Shoji S
Ubiquitinated alpha B-crystallin in glial cytoplasmic inclusions from the brain of a patient with multiple system atrophy.
Journal of the neurological sciences 1995;129(2):192-8.
1995: Shirasawa T; Endoh R; Zeng Y X; Sakamoto K; Mori H
Protein L-isoaspartyl methyltransferase: developmentally regulated gene expression and protein localization in the central nervous system of aged rat.
Neuroscience letters 1995;188(1):37-40.
1995: Mori H; Hosoda K; Matsubara E; Nakamoto T; Furiya Y; Endoh R; Usami M; Shoji M; Maruyama S; Hirai S
Tau in cerebrospinal fluids: establishment of the sandwich ELISA with antibody specific to the repeat sequence in tau.
Neuroscience letters 1995;186(2-3):181-3.
1995: Sumiyoshi T; Suzuki K; Sakamoto H; Yamaguchi N; Mori H; Shiba K; Yokogawa K
Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1995;12(1):57-64.
1994: Uéda K; Saitoh T; Mori H
Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer's disease amyloid.
Biochemical and biophysical research communications 1994;205(2):1366-72.
1994: Tamaoka A; Kondo T; Odaka A; Sahara N; Sawamura N; Ozawa K; Suzuki N; Shoji S; Mori H
Biochemical evidence for the long-tail form (A beta 1-42/43) of amyloid beta protein as a seed molecule in cerebral deposits of Alzheimer's disease.
Biochemical and biophysical research communications 1994;205(1):834-42.
1994: Mori H; Ishii K; Tomiyama T; Furiya Y; Sahara N; Asano S; Endo N; Shirasawa T; Takio K
Racemization: its biological significance on neuropathogenesis of Alzheimer's disease.
The Tohoku journal of experimental medicine 1994;174(3):251-62.
1994: Tomiyama T; Asano S; Suwa Y; Morita T; Kataoka K; Mori H; Endo N
Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro.
Biochemical and biophysical research communications 1994;204(1):76-83.
1994: Tomiyama T; Asano S; Furiya Y; Shirasawa T; Endo N; Mori H
Racemization of Asp23 residue affects the aggregation properties of Alzheimer amyloid beta protein analogues.
The Journal of biological chemistry 1994;269(14):10205-8.
1994: Sumiyoshi T; Kido H; Sakamoto H; Urasaki K; Suzuki K; Yamaguchi N; Mori H; Shiba K; Yokogawa K
In vivo dopamine-D2 and serotonin-5-HT2 receptor binding study of risperidone and haloperidol.
Pharmacology, biochemistry, and behavior 1994;47(3):553-7.
1994: Kawahara M; Muramoto K; Kobayashi K; Mori H; Kuroda Y
Aluminum promotes the aggregation of Alzheimer's amyloid beta-protein in vitro.
Biochemical and biophysical research communications 1994;198(2):531-5.
1994: Mori H; Nishimura M; Namba Y; Oda M
Corticobasal degeneration: a disease with widespread appearance of abnormal tau and neurofibrillary tangles, and its relation to progressive supranuclear palsy.
Acta neuropathologica 1994;88(2):113-21.
1994: Uchihara T; Mitani K; Mori H; Kondo H; Yamada M; Ikeda K
Abnormal cytoskeletal pathology peculiar to corticobasal degeneration is different from that of Alzheimer's disease or progressive supranuclear palsy.
Acta neuropathologica 1994;88(4):379-83.
1993: Furiya Y; Sahara N; Mori H
Okadaic acid enhances abnormal phosphorylation on tau proteins.
Neuroscience letters 1993;156(1-2):67-9.
1993: Endoh R; Ogawara M; Iwatsubo T; Nakano I; Mori H
Lack of the carboxyl terminal sequence of tau in ghost tangles of Alzheimer's disease.
Brain research 1993;601(1-2):164-72.
1993: Takahashi H; Utsuyama M; Kurashima C; Mori H; Hirokawa K
Monoclonal antibody to beta peptide, recognizing amyloid deposits, neuronal cells and lipofuscin pigments in systemic organs.
Acta neuropathologica 1993;85(2):159-66.
1992: Yoshimura M; Yamanouchi H; Kuzuhara S; Mori H; Sugiura S; Mizutani T; Shimada H; Tomonaga M; Toyokura Y
Dementia in cerebral amyloid angiopathy: a clinicopathological study.
Journal of neurology 1992;239(8):441-50.
1992: Mori H; Takio K; Ogawara M; Selkoe D J
Mass spectrometry of purified amyloid beta protein in Alzheimer's disease.
The Journal of biological chemistry 1992;267(24):17082-6.
1992: Mori H; Mizutani T; Yoshimura M; Yamanouchi H; Shimada H
Unilateral brain damage after prolonged hemiconvulsions in the elderly associated with theophylline administration.
Journal of neurology, neurosurgery, and psychiatry 1992;55(6):466-9.
1991: Mori H; Ihara Y
Neurofibrillary tangles, dystrophic neurites (curly fibers), and abnormal phosphorylation of tau.
Brain pathology (Zurich, Switzerland) 1991;1(4):273-7.
1990: Mori H; Yoshimura M; Mizutani T; Kuzuhara S; Yamanouchi H; Shimada H; Tomonaga M
[An autopsy case of postencephalitic parkinsonism: investigation on neurofibrillary tangles in comparison with those in progressive supranuclear palsy]
No to shinkei = Brain and nerve 1990;42(6):553-9.
1990: Mori H; Selkoe D J
[Biochemistry of Alzheimer's disease]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1990;35(7 Suppl):1353-61.
1990: Murayama S; Mori H; Ihara Y; Tomonaga M
Immunocytochemical and ultrastructural studies of Pick's disease.
Annals of neurology 1990;27(4):394-405.
1990: Murayama S; Mori H; Ihara Y; Bouldin T W; Suzuki K; Tomonaga M
Immunocytochemical and ultrastructural studies of lower motor neurons in amyotrophic lateral sclerosis.
Annals of neurology 1990;27(2):137-48.
1990: Kobayashi S; Mori H; Ikeuchi S; Takakura K
[Immunohistochemical study on Rosenthal fibers in gliomas using anti-GFAP and anti-ubiquitin antibodies]
No to shinkei = Brain and nerve 1990;42(1):59-64.
1990: Mizutani T; Amano N; Sasaki H; Morimatsu Y; Mori H; Yoshimura M; Yamanouchi H; Hayakawa K; Shimada H
Senile dementia of Alzheimer type characterized by laminar neuronal loss exclusively in the hippocampus, parahippocampus and medial occipitotemporal cortex.
Acta neuropathologica 1990;80(6):575-80.
1990: Ohtsubo K; Izumiyama N; Kuzuhara S; Mori H; Shimada H
Curly fibers are tau-positive strands in the pre- and post-synaptic neurites, consisting of paired helical filaments: observations by the freeze-etch and replica method.
Acta neuropathologica 1990;81(2):111-5.
1990: Ihara Y; Kondo J; Miura R; Nakagawa Y; Mori H; Honda T
Characterization of antisera to paired helical filaments and tau. Implication for the extent of tau tightly bound to paired helical filaments.
Gerontology 1990;36 Suppl 1():15-24.
1989: Joachim C L; Mori H; Selkoe D J
Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease.
Nature 1989;341(6239):226-30.
1989: Kanai Y; Takemura R; Oshima T; Mori H; Ihara Y; Yanagisawa M; Masaki T; Hirokawa N
Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.
The Journal of cell biology 1989;109(3):1173-84.
1989: Mori H; Hamada Y; Kawaguchi M; Honda T; Kondo J; Ihara Y
A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments.
Biochemical and biophysical research communications 1989;159(3):1221-6.
1989: Murayama S; Ookawa Y; Mori H; Nakano I; Ihara Y; Kuzuhara S; Tomonaga M
Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis.
Acta neuropathologica 1989;78(2):143-52.
1988: Kondo J; Honda T; Mori H; Hamada Y; Miura R; Ogawara M; Ihara Y
The carboxyl third of tau is tightly bound to paired helical filaments.
Neuron 1988;1(9):827-34.
1988: Kuzuhara S; Mori H; Izumiyama N; Yoshimura M; Ihara Y
Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study.
Acta neuropathologica 1988;75(4):345-53.
1987: Mori H; Kondo J; Ihara Y
Ubiquitin is a component of paired helical filaments in Alzheimer's disease.
Science (New York, N.Y.) 1987;235(4796):1641-4.
1987: Mori H; Tomonaga M
[Scanning electron microscopy and X-ray spectrometric studies of Hirano bodies: aluminum accumulation in Hirano bodies]
Rinsho shinkeigaku = Clinical neurology 1987;27(1):74-8.
1986: Mori H; Yoshimura M; Tomonaga M; Yamanouchi H
Progressive supranuclear palsy with Lewy bodies.
Acta neuropathologica 1986;71(3-4):344-6.
1984: Yoshimura M; Mori H; Tomonaga M; Yamanouchi H; Kuzuhara S
[Loss of neurons in the nucleus basalis of Meynert in Parkinson disease with dementia, "diffuse Lewy body disease" and senile dementia of Alzheimer type]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 1984;21(6):580-7.

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