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Shigeki Moriguchi

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Shigeki Moriguchi; Toshio Narahashi; Hideaki Tagashira; Tomoya Tanaka; Kohji Fukunaga
Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice.
Y Yabuki; Shigeki Moriguchi; O Nakagawasai; H Onogi; Norifumi Shioda; T Tadano; K Tan-No; Kohji Fukunaga
Decreased CaMKII and PKC activities in specific brain regions are associated with cognitive impairment in neonatal ventral hippocampus-lesioned rats.
Shigeki Moriguchi; Yuzuru Sasaki; Yasuharu Shinoda; Hideaki Tagashira; Yui Yamamoto; Kosuke Miyajima; Kohji Fukunaga
Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Efficacy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice.

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2013: Shigeki Moriguchi; Toshio Narahashi; Hideaki Tagashira; Tomoya Tanaka; Kohji Fukunaga
Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice.
Behavioural brain research 2013;242():150-7.
2013: Y Yabuki; Shigeki Moriguchi; O Nakagawasai; H Onogi; Norifumi Shioda; T Tadano; K Tan-No; Kohji Fukunaga
Decreased CaMKII and PKC activities in specific brain regions are associated with cognitive impairment in neonatal ventral hippocampus-lesioned rats.
Neuroscience 2013;234():103-15.
2013: Shigeki Moriguchi; Yuzuru Sasaki; Yasuharu Shinoda; Hideaki Tagashira; Yui Yamamoto; Kosuke Miyajima; Kohji Fukunaga
Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Efficacy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice.
PloS one 2013;8(4):e60863.
2013: Yui Yamamoto; Feng Han; Shigeki Moriguchi; Norifumi Shioda; Kohji Fukunaga
The novel cognitive enhancer ST101 enhances acetylcholine release in mouse dorsal hippocampus through T-type voltage-gated calcium channel stimulation.
Journal of pharmacological sciences 2013;121(3):212-26.
2012: Norifumi Shioda; Yoko Ishii; Takako Matsushima; Shigeki Moriguchi; Hisao Nishijo; Takeshi Oya; Masakiyo Sasahara; Jie Shen; Kohji Fukunaga
Aberrant hippocampal spine morphology and impaired memory formation in neuronal platelet-derived growth factor β-receptor lacking mice.
Hippocampus 2012;22(6):1371-8.
2012: Shigeki Moriguchi; Norifumi Shioda; Hideaki Tagashira; Yui Yamamoto; Kohji Fukunaga
The T-type voltage-gated calcium channel as a molecular target of the novel cognitive enhancer ST101: enhancement of long-term potentiation and CaMKII autophosphorylation in rat cortical slices.
Journal of neurochemistry 2012;121(1):44-53.
2012: Shigeki Moriguchi; Yasushi Yabuki; Kohji Fukunaga
Reduced calcium/calmodulin-dependent protein kinase II activity in the hippocampus is associated with impaired cognitive function in MPTP-treated mice.
Journal of neurochemistry 2012;120(4):541-51.
2011: Shigeki Moriguchi; Yui Yamamoto; Tatsuya Ikuno; Kohji Fukunaga
Sigma-1 receptor stimulation by dehydroepiandrosterone ameliorates cognitive impairment through activation of CaM kinase II, protein kinase C and extracellular signal-regulated kinase in olfactory bulbectomized mice.
Journal of neurochemistry 2011;117(5):879-91.
2011: Norifumi Shioda; Yui Yamamoto; Feng Han; Shigeki Moriguchi; Kohji Fukunaga
[Neurochemical mechanisms of a novel Alzheimer's disease therapeutics on improvement of cognition and depressive behavior].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2011;131(4):505-11.
2011: Shigeki Moriguchi
Pharmacological study on Alzheimer's drugs targeting calcium/calmodulin-dependent protein kinase II.
Journal of pharmacological sciences 2011;117(1):6-11.
2011: Shigeki Moriguchi; Yutaka Oomura; Norifumi Shioda; Feng Han; Nobuaki Hori; Shuji Aou; Kohji Fukunaga
Ca2+/calmodulin-dependent protein kinase II and protein kinase C activities mediate extracellular glucose-regulated hippocampal synaptic efficacy.
Molecular and cellular neurosciences 2011;46(1):101-7.
2010: Yui Yamamoto; Norifumi Shioda; Feng Han; Shigeki Moriguchi; Kohji Fukunaga
[Donepezil-induced neuroprotection of acetylcholinergic neurons in olfactory bulbectomized mice].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(5):717-21.
2010: Shigeki Moriguchi; Norifumi Shioda; Y Yamamoto; Kohji Fukunaga
Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region.
Neuroscience 2010;166(4):1158-66.
2010: Norifumi Shioda; Yui Yamamoto; Feng Han; Shigeki Moriguchi; Yoshimasa Yamaguchi; Masataka Hino; Kohji Fukunaga
A novel cognitive enhancer, ZSET1446/ST101, promotes hippocampal neurogenesis and ameliorates depressive behavior in olfactory bulbectomized mice.
The Journal of pharmacology and experimental therapeutics 2010;333(1):43-50.
2009: Yui Yamamoto; Norifumi Shioda; Feng Han; Shigeki Moriguchi; Akira Nakajima; Akihito Yokosuka; Yoshihiro Mimaki; Yutaka Sashida; Tohru Yamakuni; Yasushi Ohizumi; Kohji Fukunaga
Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.
Brain research 2009;1295():218-29.
2009: Shigeki Moriguchi; Norifumi Shioda; Feng Han; Jay Z Yeh; Toshio Narahashi; Kohji Fukunaga
Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation.
Hippocampus 2009;19(9):844-54.
2009: Shigeki Moriguchi; Feng Han; Norifumi Shioda; Yui Yamamoto; Takeharu Nakajima; Osamu Nakagawasai; Takeshi Tadano; Jay Z Yeh; Toshio Narahashi; Kohji Fukunaga
Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice.
Journal of neurochemistry 2009;110(1):170-81.
2009: Shigeki Moriguchi; Xilong Zhao; William Marszalec; Jay Z Yeh; Kohji Fukunaga; Toshio Narahashi
Nefiracetam and galantamine modulation of excitatory and inhibitory synaptic transmission via stimulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons.
Neuroscience 2009;160(2):484-91.
2008: Shigeki Moriguchi; Norifumi Shioda; Feng Han; Toshio Narahashi; Kohji Fukunaga
CaM kinase II and protein kinase C activations mediate enhancement of long-term potentiation by nefiracetam in the rat hippocampal CA1 region.
Journal of neurochemistry 2008;106(3):1092-103.
2008: Feng Han; Norifumi Shioda; Shigeki Moriguchi; Yui Yamamoto; Alisa Y Ali Raie; Yoshimasa Yamaguchi; Masataka Hino; Kohji Fukunaga
Spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101) treatment rescues olfactory bulbectomy-induced memory impairment by activating Ca2+/calmodulin kinase II and protein kinase C in mouse hippocampus.
The Journal of pharmacology and experimental therapeutics 2008;326(1):127-34.
2008: Feng Han; Norifumi Shioda; Shigeki Moriguchi; Z-H Qin; Kohji Fukunaga
The vanadium (IV) compound rescues septo-hippocampal cholinergic neurons from neurodegeneration in olfactory bulbectomized mice.
Neuroscience 2008;151(3):671-9.
2008: Feng Han; Norifumi Shioda; Shigeki Moriguchi; Zheng-Hong Qin; Kohji Fukunaga
Downregulation of glutamate transporters is associated with elevation in extracellular glutamate concentration following rat microsphere embolism.
Neuroscience letters 2008;430(3):275-80.
2008: Kentaro Matsuzaki; Kenichi Miyazaki; Seiichiro Sakai; Hiromu Yawo; Norihito Nakata; Shigeki Moriguchi; Kohji Fukunaga; Akihito Yokosuka; Yutaka Sashida; Yoshihiro Mimaki; Tohru Yamakuni; Yasushi Ohizumi
Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus.
European journal of pharmacology 2008;578(2-3):194-200.
2008: Sho Kakizawa; Shigeki Moriguchi; Atsushi Ikeda; Masamitsu Iino; Hiroshi Takeshima
Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions.
Cerebellum (London, England) 2008;7(3):385-91.
2008: Md Shenuarin Bhuiyan; Yoko Takada; Norifumi Shioda; Shigeki Moriguchi; Jiro Kasahara; Kohji Fukunaga
Cardioprotective effect of vanadyl sulfate on ischemia/reperfusion-induced injury in rat heart in vivo is mediated by activation of protein kinase B and induction of FLICE-inhibitory protein.
Cardiovascular therapeutics 2008;26(1):10-23.
2007: Ying-Mei Lu; Norifumi Shioda; Feng Han; Shigeki Moriguchi; Jiro Kasahara; Yasufumi Shirasaki; Zheng-Hong Qin; Kohji Fukunaga
Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes.
Biochemical pharmacology 2007;74(12):1727-37.
2007: Md Shenuarin Bhuiyan; Masatoshi Shibuya; Norifumi Shioda; Shigeki Moriguchi; Jiro Kasahara; Yosiharu Iwabuchi; Kohji Fukunaga
Cytoprotective effect of bis(1-oxy-2-pyridinethiolato)oxovanadiun(IV) on myocardial ischemia/reperfusion injury elicits inhibition of Fas ligand and Bim expression and elevation of FLIP expression.
European journal of pharmacology 2007;571(2-3):180-8.
2007: Norifumi Shioda; Feng Han; Shigeki Moriguchi; Kohji Fukunaga
Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia.
Journal of neurochemistry 2007;102(5):1506-17.
2007: Norifumi Shioda; T Ishigami; Feng Han; Shigeki Moriguchi; M Shibuya; Y Iwabuchi; Kohji Fukunaga
Activation of phosphatidylinositol 3-kinase/protein kinase B pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia.
Neuroscience 2007;148(1):221-9.
2007: Shigeki Moriguchi; Norifumi Shioda; Hiroshi Maejima; Xilong Zhao; William Marszalec; Jay Z Yeh; Kohji Fukunaga; Toshio Narahashi
Nefiracetam potentiates N-methyl-D-aspartate (NMDA) receptor function via protein kinase C activation and reduces magnesium block of NMDA receptor.
Molecular pharmacology 2007;71(2):580-7.
2007: Shigeki Moriguchi; Xilong Zhao; William Marszalec; Jay Z Yeh; Toshio Narahashi
Effects of ethanol on excitatory and inhibitory synaptic transmission in rat cortical neurons.
Alcoholism, clinical and experimental research 2007;31(1):89-99.
2006: Takuya Sasaki; Feng Han; Norifumi Shioda; Shigeki Moriguchi; Jiro Kasahara; Koichi Ishiguro; Kohji Fukunaga
Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model.
Brain research 2006;1108(1):98-106.
2006: Shigeki Moriguchi; Miyuki Nishi; Shinji Komazaki; Hiroyuki Sakagami; Taisuke Miyazaki; Haruko Masumiya; Shin-Ya Saito; Masahiko Watanabe; Hisatake Kondo; Hiromu Yawo; Kohji Fukunaga; Hiroshi Takeshima
Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10811-6.
2006: Norifumi Shioda; Shigeki Moriguchi; Yasufumi Shirasaki; Kohji Fukunaga
Generation of constitutively active calcineurin by calpain contributes to delayed neuronal death following mouse brain ischemia.
Journal of neurochemistry 2006;98(1):310-20.
2006: Shigeki Moriguchi; Feng Han; Osamu Nakagawasai; Takeshi Tadano; Kohji Fukunaga
Decreased calcium/calmodulin-dependent protein kinase II and protein kinase C activities mediate impairment of hippocampal long-term potentiation in the olfactory bulbectomized mice.
Journal of neurochemistry 2006;97(1):22-9.
2006: Kohji Fukunaga; Feng Han; Norifumi Shioda; Shigeki Moriguchi; Jiro Kasahara; Yasufumi Shirasaki
DY-9760e, a novel calmodulin inhibitor, exhibits cardioprotective effects in the ischemic heart.
Cardiovascular drug reviews 2006;24(2):88-100.
2005: Shigeki Moriguchi; Xilong Zhao; William Marszalec; Jay Z Yeh; Toshio Narahashi
Modulation of N-methyl-D-aspartate receptors by donepezil in rat cortical neurons.
The Journal of pharmacology and experimental therapeutics 2005;315(1):125-35.
2005: Takashi Shirakura; Feng Han; Norifumi Shiota; Shigeki Moriguchi; Jiro Kasahara; Toshiyuki Sato; Yasufumi Shirasaki; Kohji Fukunaga
Inhibition of nitric oxide production and protein tyrosine nitration contribute to neuroprotection by a novel calmodulin antagonist, DY-9760e, in the rat microsphere embolism.
Biological & pharmaceutical bulletin 2005;28(9):1658-61.
2004: Toshio Narahashi; Shigeki Moriguchi; Xilong Zhao; William Marszalec; Jay Z Yeh
Mechanisms of action of cognitive enhancers on neuroreceptors.
Biological & pharmaceutical bulletin 2004;27(11):1701-6.
2004: Shigeki Moriguchi; William Marszalec; Xilong Zhao; Jay Z Yeh; Toshio Narahashi
Mechanism of action of galantamine on N-methyl-D-aspartate receptors in rat cortical neurons.
The Journal of pharmacology and experimental therapeutics 2004;310(3):933-42.
2003: Toshio Narahashi; William Marszalec; Shigeki Moriguchi; Jay Z Yeh; Xilong Zhao
Unique mechanism of action of Alzheimer's drugs on brain nicotinic acetylcholine receptors and NMDA receptors.
Life sciences 2003;74(2-3):281-91.
2003: Shigeki Moriguchi; William Marszalec; Xilong Zhao; Jay Z Yeh; Toshio Narahashi
Potentiation of N-methyl-D-aspartate-induced currents by the nootropic drug nefiracetam in rat cortical neurons.
The Journal of pharmacology and experimental therapeutics 2003;307(1):160-7.