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Richard Morimoto
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11
Sarge, Kevin
8
Freeman, BC
8
Jolly, Caroline
6
Cotto, Jose
6
Sistonen, Lea
5
Westerheide, Sandy
5
Kim, Soojin
5
Brignull, Heather
4
Kroeger, Paul
4
Morley, James
4
Nollen, Ellen
3
Mathew, A
3
Vourc'h, Claire
3
Carr, Virginia McMillan
3
Bimston, DN
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All Publications
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2009: Ben-Zvi Anat; Miller Elizabeth A; Morimoto Richard I
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(35):14914-9.
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2009: Gidalevitz Tali; Krupinski Thomas; Garcia Susana; Morimoto Richard I
Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity.
PLoS genetics 2009;5(3):e1000399.
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2009: Westerheide Sandy D; Anckar Julius; Stevens Stanley M; Sistonen Lea; Morimoto Richard I
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.
Science (New York, N.Y.) 2009;323(5917):1063-6.
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2009: Prahlad Veena; Morimoto Richard I
Integrating the stress response: lessons for neurodegenerative diseases from C. elegans.
Trends in cell biology 2009;19(2):52-61.
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2008: Morimoto Richard I
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging.
Genes & development 2008;22(11):1427-38.
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2008: Prahlad Veena; Cornelius Tyler; Morimoto Richard I
Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons.
Science (New York, N.Y.) 2008;320(5877):811-4.
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2008: Trott Amy; West James D; Klaic Lada; Westerheide Sandy D; Silverman Richard B; Morimoto Richard I; Morano Kevin A
Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule.
Molecular biology of the cell 2008;19(3):1104-12.
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2007: Garcia Susana M; Casanueva M Olivia; Silva M Catarina; Amaral Margarida D; Morimoto Richard I
Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells.
Genes & development 2007;21(22):3006-16.
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2007: Brignull Heather R; Morley James F; Morimoto Richard I
The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging.
Advances in experimental medicine and biology 2007;594():167-89.
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2006: Morimoto Richard I
Stress, aging, and neurodegenerative disease.
The New England journal of medicine 2006;355(21):2254-5.
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2006: Brignull Heather R; Moore Finola E; Tang Stephanie J; Morimoto Richard I
Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(29):7597-606.
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2006: Westerheide Sandy D; Kawahara Tiara L A; Orton Kai; Morimoto Richard I
Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death.
The Journal of biological chemistry 2006;281(14):9616-22.
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2006: Gidalevitz Tali; Ben-Zvi Anat; Ho Kim H; Brignull Heather R; Morimoto Richard I
Progressive disruption of cellular protein folding in models of polyglutamine diseases.
Science (New York, N.Y.) 2006;311(5766):1471-4.
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2006: Matsumoto Gen; Kim Soojin; Morimoto Richard I
Huntingtin and mutant SOD1 form aggregate structures with distinct molecular properties in human cells.
The Journal of biological chemistry 2006;281(7):4477-85.
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2006: Rieger Theodore R; Morimoto Richard I; Hatzimanikatis Vassily
Bistability explains threshold phenomena in protein aggregation both in vitro and in vivo.
Biophysical journal 2006;90(3):886-95.
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2006: Brignull Heather R; Morley James F; Garcia Susana M; Morimoto Richard I
Modeling polyglutamine pathogenesis in C. elegans.
Methods in enzymology 2006;412():256-82.
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2005: Matsumoto Gen; Stojanovic Aleksandar; Holmberg Carina I; Kim Soojin; Morimoto Richard I
Structural properties and neuronal toxicity of amyotrophic lateral sclerosis-associated Cu/Zn superoxide dismutase 1 aggregates.
The Journal of cell biology 2005;171(1):75-85.
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2005: Westerheide Sandy D; Morimoto Richard I
Heat shock response modulators as therapeutic tools for diseases of protein conformation.
The Journal of biological chemistry 2005;280(39):33097-100.
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2005: Rieger Theodore R; Morimoto Richard I; Hatzimanikatis Vassily
Mathematical modeling of the eukaryotic heat-shock response: dynamics of the hsp70 promoter.
Biophysical journal 2005;88(3):1646-58.
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2004: Westerheide Sandy D; Bosman Joshua D; Mbadugha Bessie N A; Kawahara Tiara L A; Matsumoto Gen; Kim Soojin; Gu Wenxin; Devlin John P; Silverman Richard B; Morimoto Richard I
Celastrols as inducers of the heat shock response and cytoprotection.
The Journal of biological chemistry 2004;279(53):56053-60.
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2004: Holmberg Carina I; Staniszewski Kristine E; Mensah Kwame N; Matouschek Andreas; Morimoto Richard I
Inefficient degradation of truncated polyglutamine proteins by the proteasome.
The EMBO journal 2004;23(21):4307-18.
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2004: Solomon Aharon; Bandhakavi Sricharan; Jabbar Sean; Shah Rena; Beitel Greg J; Morimoto Richard I
Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments.
Genetics 2004;167(1):161-70.
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2004: Nollen Ellen A A; Garcia Susana M; van Haaften Gijs; Kim Soojin; Chavez Alejandro; Morimoto Richard I; Plasterk Ronald H A
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6403-8.
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2004: Morley James F; Morimoto Richard I
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones.
Molecular biology of the cell 2004;15(2):657-64.
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2002: Kim Soojin; Nollen Ellen A A; Kitagawa Kazunori; Bindokas Vytautas P; Morimoto Richard I
Polyglutamine protein aggregates are dynamic.
Nature cell biology 2002;4(10):826-31.
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2002: Morimoto Richard I
Dynamic remodeling of transcription complexes by molecular chaperones.
Cell 2002;110(3):281-4.
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2002: Morley James F; Brignull Heather R; Weyers Jill J; Morimoto Richard I
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10417-22.
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2002: Nollen Ellen A A; Morimoto Richard I
Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins.
Journal of cell science 2002;115(Pt 14):2809-16.
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2002: Jolly Caroline; Konecny Lara; Grady Deborah L; Kutskova Yulia A; Cotto Jose J; Morimoto Richard I; Vourc'h Claire
In vivo binding of active heat shock transcription factor 1 to human chromosome 9 heterochromatin during stress.
The Journal of cell biology 2002;156(5):775-81.
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2002: Tai Li-Jung; McFall Sally M; Huang Kai; Demeler Borries; Fox Sue G; Brubaker Kurt; Radhakrishnan Ishwar; Morimoto Richard I
Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain.
The Journal of biological chemistry 2002;277(1):735-45.
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2001: Mathew A; Mathur S K; Jolly C; Fox S G; Kim S; Morimoto R I
Stress-specific activation and repression of heat shock factors 1 and 2.
Molecular and cellular biology 2001;21(21):7163-71.
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2001: Carr V M; Menco B P; Yankova M P; Morimoto R I; Farbman A I
Odorants as cell-type specific activators of a heat shock response in the rat olfactory mucosa.
The Journal of comparative neurology 2001;432(4):425-39.
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2001: Song J; Takeda M; Morimoto R I
Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth.
Nature cell biology 2001;3(3):276-82.
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2000: Jolly C; Morimoto R I
Role of the heat shock response and molecular chaperones in oncogenesis and cell death.
Journal of the National Cancer Institute 2000;92(19):1564-72.
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2000: Satyal S H; Schmidt E; Kitagawa K; Sondheimer N; Lindquist S; Kramer J M; Morimoto R I
Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5750-5.
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2000: Nollen E A; Brunsting J F; Song J; Kampinga H H; Morimoto R I
Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity.
Molecular and cellular biology 2000;20(3):1083-8.
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2000: Freeman B C; Michels A; Song J; Kampinga H H; Morimoto R I
Analysis of molecular chaperone activities using in vitro and in vivo approaches.
Methods in molecular biology (Clifton, N.J.) 2000;99():393-419.
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2000: Mathew A; Shi Y; Jolly C; Morimoto R I
Analysis of the mammalian heat-shock response. Inducible gene expression and heat-shock factor activity.
Methods in molecular biology (Clifton, N.J.) 2000;99():217-55.
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1999: Jolly C; Vourc'h C; Robert-Nicoud M; Morimoto R I
Intron-independent association of splicing factors with active genes.
The Journal of cell biology 1999;145(6):1133-43.
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1999: Jolly C; Usson Y; Morimoto R I
Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6769-74.
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1999: Carr V M; Morimoto R I; Farbman A I
Development and further characterization of a small subclass of rat olfactory receptor neurons that shows immunoreactivity for the HSP70 heat shock protein.
The Journal of comparative neurology 1999;404(3):375-86.
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1999: Jolly C; Morimoto R I
Stress and the cell nucleus: dynamics of gene expression and structural reorganization.
Gene expression 1999;7(4-6):261-70.
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1999: Cotto J J; Morimoto R I
Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors.
Biochemical Society symposium 1999;64():105-18.
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1998: Morimoto R I
Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.
Genes & development 1998;12(24):3788-96.
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1998: Bimston D; Song J; Winchester D; Takayama S; Reed J C; Morimoto R I
BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release.
The EMBO journal 1998;17(23):6871-8.
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1998: Morimoto R I; Santoro M G
Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection.
Nature biotechnology 1998;16(9):833-8.
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1998: Mathew A; Mathur S K; Morimoto R I
Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway.
Molecular and cellular biology 1998;18(9):5091-8.
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1998: Satyal S H; Chen D; Fox S G; Kramer J M; Morimoto R I
Negative regulation of the heat shock transcriptional response by HSBP1.
Genes & development 1998;12(13):1962-74.
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1998: Shi Y; Mosser D D; Morimoto R I
Molecular chaperones as HSF1-specific transcriptional repressors.
Genes & development 1998;12(5):654-66.
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1997: Jolly C; Morimoto R; Robert-Nicoud M; Vourc'h C
HSF1 transcription factor concentrates in nuclear foci during heat shock: relationship with transcription sites.
Journal of cell science 1997;110 ( Pt 23)():2935-41.
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1997: Cotto J; Fox S; Morimoto R
HSF1 granules: a novel stress-induced nuclear compartment of human cells.
Journal of cell science 1997;110 ( Pt 23)():2925-34.
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1997: Takayama S; Bimston D N; Matsuzawa S; Freeman B C; Aime-Sempe C; Xie Z; Morimoto R I; Reed J C
BAG-1 modulates the chaperone activity of Hsp70/Hsc70.
The EMBO journal 1997;16(16):4887-96.
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1997: Kimura Y; Rutherford S L; Miyata Y; Yahara I; Freeman B C; Yue L; Morimoto R I; Lindquist S
Cdc37 is a molecular chaperone with specific functions in signal transduction.
Genes & development 1997;11(14):1775-85.
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1997: Kline M P; Morimoto R I
Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation.
Molecular and cellular biology 1997;17(4):2107-15.
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1997: Morimoto R I; Kline M P; Bimston D N; Cotto J J
The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones.
Essays in biochemistry 1997;32():17-29.
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1996: Freeman B C; Toft D O; Morimoto R I
Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23.
Science (New York, N.Y.) 1996;274(5293):1718-20.
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1996: Hansen S; Midgley C A; Lane D P; Freeman B C; Morimoto R I; Hupp T R
Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70.
The Journal of biological chemistry 1996;271(48):30922-8.
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1996: Freeman B C; Morimoto R I
The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding.
The EMBO journal 1996;15(12):2969-79.
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1996: Cotto J J; Kline M; Morimoto R I
Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation.
The Journal of biological chemistry 1996;271(7):3355-8.
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1996: Marcuccilli C J; Mathur S K; Morimoto R I; Miller R J
Regulatory differences in the stress response of hippocampal neurons and glial cells after heat shock.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(2):478-85.
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1996: Morimoto R I
Outlook.
EXS 1996;77():485-7.
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1996: Morimoto R I; Kroeger P E; Cotto J J
The transcriptional regulation of heat shock genes: a plethora of heat shock factors and regulatory conditions.
EXS 1996;77():139-63.
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1995: Lee B S; Chen J; Angelidis C; Jurivich D A; Morimoto R I
Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7207-11.
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1995: Shi Y; Kroeger P E; Morimoto R I
The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive.
Molecular and cellular biology 1995;15(8):4309-18.
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1995: Freeman B C; Myers M P; Schumacher R; Morimoto R I
Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1.
The EMBO journal 1995;14(10):2281-92.
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1995: Bhattacharyya T; Karnezis A N; Murphy S P; Hoang T; Freeman B C; Phillips B; Morimoto R I
Cloning and subcellular localization of human mitochondrial hsp70.
The Journal of biological chemistry 1995;270(4):1705-10.
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1994: Kroeger P E; Morimoto R I
Selection of new HSF1 and HSF2 DNA-binding sites reveals difference in trimer cooperativity.
Molecular and cellular biology 1994;14(11):7592-603.
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1994: Carr V M; Murphy S P; Morimoto R I; Farbman A I
Small subclass of rat olfactory neurons with specific bulbar projections is reactive with monoclonal antibodies to the HSP70 heat shock protein.
The Journal of comparative neurology 1994;348(1):150-60.
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1994: Mathur S K; Sistonen L; Brown I R; Murphy S P; Sarge K D; Morimoto R I
Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8695-9.
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1994: Sarge K D; Park-Sarge O K; Kirby J D; Mayo K E; Morimoto R I
Expression of heat shock factor 2 in mouse testis: potential role as a regulator of heat-shock protein gene expression during spermatogenesis.
Biology of reproduction 1994;50(6):1334-43.
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1994: Jurivich D A; Sistonen L; Sarge K D; Morimoto R I
Arachidonate is a potent modulator of human heat shock gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2280-4.
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1994: Sistonen L; Sarge K D; Morimoto R I
Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription.
Molecular and cellular biology 1994;14(3):2087-99.
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1993: Kroeger P E; Sarge K D; Morimoto R I
Mouse heat shock transcription factors 1 and 2 prefer a trimeric binding site but interact differently with the HSP70 heat shock element.
Molecular and cellular biology 1993;13(6):3370-83.
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1993: Nakai A; Morimoto R I
Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway.
Molecular and cellular biology 1993;13(4):1983-97.
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1993: Morimoto R I
Cells in stress: transcriptional activation of heat shock genes.
Science (New York, N.Y.) 1993;259(5100):1409-10.
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1993: Sarge K D; Murphy S P; Morimoto R I
Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.
Molecular and cellular biology 1993;13(3):1392-407.
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1992: Morimoto R I; Sarge K D; Abravaya K
Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses.
The Journal of biological chemistry 1992;267(31):21987-90.
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1992: Sistonen L; Sarge K D; Phillips B; Abravaya K; Morimoto R I
Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells.
Molecular and cellular biology 1992;12(9):4104-11.
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1992: Abravaya K; Myers M P; Murphy S P; Morimoto R I
The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression.
Genes & development 1992;6(7):1153-64.
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1992: Jurivich D A; Sistonen L; Kroes R A; Morimoto R I
Effect of sodium salicylate on the human heat shock response.
Science (New York, N.Y.) 1992;255(5049):1243-5.
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1991: Abravaya K; Phillips B; Morimoto R I
Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures.
Genes & development 1991;5(11):2117-27.
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1991: Phillips B; Abravaya K; Morimoto R I
Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses.
Journal of virology 1991;65(11):5680-92.
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1991: Sarge K D; Zimarino V; Holm K; Wu C; Morimoto R I
Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability.
Genes & development 1991;5(10):1902-11.
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1991: Watowich S S; Morimoto R I; Lamb R A
Flux of the paramyxovirus hemagglutinin-neuraminidase glycoprotein through the endoplasmic reticulum activates transcription of the GRP78-BiP gene.
Journal of virology 1991;65(7):3590-7.
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1991: Kroes R A; Abravaya K; Seidenfeld J; Morimoto R I
Selective activation of human heat shock gene transcription by nitrosourea antitumor drugs mediated by isocyanate-induced damage and activation of heat shock transcription factor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4825-9.
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1991: Abravaya K; Phillips B; Morimoto R I
Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting.
Molecular and cellular biology 1991;11(1):586-92.
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1991: Sarge K D; Morimoto R I
Surprising features of transcriptional regulation of heat shock genes.
Gene expression 1991;1(3):169-73.
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1991: Phillips B; Morimoto R I
Transcriptional regulation of human hsp70 genes: relationship between cell growth, differentiation, virus infection, and the stress response.
Results and problems in cell differentiation 1991;17():167-87.
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1990: Williams G T; Morimoto R I
Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment.
Molecular and cellular biology 1990;10(6):3125-36.
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1990: Mosser D D; Kotzbauer P T; Sarge K D; Morimoto R I
In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3748-52.
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1989: Milarski K L; Morimoto R I
Mutational analysis of the human HSP70 protein: distinct domains for nucleolar localization and adenosine triphosphate binding.
The Journal of cell biology 1989;109(5):1947-62.
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1989: Theodorakis N G; Zand D J; Kotzbauer P T; Williams G T; Morimoto R I
Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response.
Molecular and cellular biology 1989;9(8):3166-73.
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1989: Williams G T; McClanahan T K; Morimoto R I
E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex.
Molecular and cellular biology 1989;9(6):2574-87.
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1989: Milarski K L; Welch W J; Morimoto R I
Cell cycle-dependent association of HSP70 with specific cellular proteins.
The Journal of cell biology 1989;108(2):413-23.
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1988: Mosser D D; Theodorakis N G; Morimoto R I
Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells.
Molecular and cellular biology 1988;8(11):4736-44.
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1988: Theodorakis N G; Banerji S S; Morimoto R I
HSP70 mRNA translation in chicken reticulocytes is regulated at the level of elongation.
The Journal of biological chemistry 1988;263(28):14579-85.
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1988: Schaefer E L; Morimoto R I; Theodorakis N G; Seidenfeld J
Chemical specificity for induction of stress response genes by DNA-damaging drugs in human adenocarcinoma cells.
Carcinogenesis 1988;9(10):1733-8.
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1988: Watowich S S; Morimoto R I
Complex regulation of heat shock- and glucose-responsive genes in human cells.
Molecular and cellular biology 1988;8(1):393-405.
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1987: Theodorakis N G; Morimoto R I
Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability.
Molecular and cellular biology 1987;7(12):4357-68.
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1987: Banerji S S; Laing K; Morimoto R I
Erythroid lineage-specific expression and inducibility of the major heat shock protein HSP70 during avian embryogenesis.
Genes & development 1987;1(9):946-53.
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1986: Milarski K L; Morimoto R I
Expression of human HSP70 during the synthetic phase of the cell cycle.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9517-21.
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1984: Banerji S S; Theodorakis N G; Morimoto R I
Heat shock-induced translational control of HSP70 and globin synthesis in chicken reticulocytes.
Molecular and cellular biology 1984;4(11):2437-48.
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