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Terry Beerman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Disorders

DNA Damage

Chemicals & Drugs

Living Beings

Physiology

DNA Replication

Anatomy

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Network (preview)

Co-Publications
Name
16
McHugh, Mary
8
Melendy, Thomas
7
Chiang, SY
7
Gawron, Loretta
5
Kuo, Shu-Ru
5
Liu, Jen-Sing
5
Bruice, Thomas
4
White, Christine
4
Rauscher, Frank
4
Dervan, Peter
4
Dziegielewski, Jaroslaw
3
Dziegielewska, Barbara
3
Kennedy, Daniel
3
Satz, Alexander
2
Tu, Lan Chun

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Publications

TOP 3
McHugh Mary; Beerman Terry
An extraction-free method by which a single slot blot can be used to quantify intracellular DNA damage (crosslinks or strand breaks) and changes in DNA damage response proteins or replication.
Beerman Terry A; Gawron Loretta S; Shin Seulkih; Shen Ben; McHugh Mary M
C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells.
Kennedy Daniel R; Ju Jianhua; Shen Ben; Beerman Terry A
Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses.

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All Publications

2009: McHugh Mary; Beerman Terry
An extraction-free method by which a single slot blot can be used to quantify intracellular DNA damage (crosslinks or strand breaks) and changes in DNA damage response proteins or replication.
BioTechniques 2009;46(2):127-9.
2009: Beerman Terry A; Gawron Loretta S; Shin Seulkih; Shen Ben; McHugh Mary M
C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells.
Cancer research 2009;69(2):593-8.
2007: Kennedy Daniel R; Ju Jianhua; Shen Ben; Beerman Terry A
Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17632-7.
2007: Kennedy Daniel R; Gawron Loretta S; Ju Jianhua; Liu Wen; Shen Ben; Beerman Terry A
Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks.
Cancer research 2007;67(2):773-81.
2006: Dziegielewska Barbara; Beerman Terry A; Bianco Piero R
Inhibition of RecBCD enzyme by antineoplastic DNA alkylating agents.
Journal of molecular biology 2006;361(5):898-919.
2006: Kennedy Daniel R; Beerman Terry A
The radiomimetic enediyne C-1027 induces unusual DNA damage responses to double-strand breaks.
Biochemistry 2006;45(11):3747-54.
2005: Tu Lan Chun; Matsui Sei Ichi; Beerman Terry A
Hedamycin, a DNA alkylator, induces (gamma)H2AX and chromosome aberrations: involvement of phosphatidylinositol 3-kinase-related kinases and DNA replication fork movement.
Molecular cancer therapeutics 2005;4(8):1175-85.
2005: McHugh Mary M; Gawron Loretta S; Matsui Sei-Ichi; Beerman Terry A
The antitumor enediyne C-1027 alters cell cycle progression and induces chromosomal aberrations and telomere dysfunction.
Cancer research 2005;65(12):5344-51.
2005: Philips Brian J; Chang Aileen Y; Dervan Peter B; Beerman Terry A
DNA damage effects of a polyamide-CBI conjugate in SV40 virions.
Molecular pharmacology 2005;67(3):877-82.
2004: Dziegielewska Barbara; Kowalski David; Beerman Terry A
SV40 DNA replication inhibition by the monofunctional DNA alkylator Et743.
Biochemistry 2004;43(44):14228-37.
2004: Tu Lan Chun; Melendy Thomas; Beerman Terry A
DNA damage responses triggered by a highly cytotoxic monofunctional DNA alkylator, hedamycin, a pluramycin antitumor antibiotic.
Molecular cancer therapeutics 2004;3(5):577-85.
2003: Cao Pei-rang; McHugh Mary M; Melendy Thomas; Beerman Terry
The DNA minor groove-alkylating cyclopropylpyrroloindole drugs adozelesin and bizelesin induce different DNA damage response pathways in human colon carcinoma HCT116 cells.
Molecular cancer therapeutics 2003;2(7):651-9.
2003: Wang Yong-Dong; Dziegielewski Jaroslaw; Wurtz Nicholas R; Dziegielewska Barbara; Dervan Peter B; Beerman Terry A
DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate.
Nucleic acids research 2003;31(4):1208-15.
2003: Liu Jen-Sing; Kuo Shu-Ru; Beerman Terry A; Melendy Thomas
Induction of DNA damage responses by adozelesin is S phase-specific and dependent on active replication forks.
Molecular cancer therapeutics 2003;2(1):41-7.
2002: Wang Yong-Dong; Dziegielewski Jaroslaw; Chang Aileen Y; Dervan Peter B; Beerman Terry A
Cell-free and cellular activities of a DNA sequence selective hairpin polyamide-CBI conjugate.
The Journal of biological chemistry 2002;277(45):42431-7.
2002: Dziegielewski Jaroslaw; Beerman Terry A
Cellular responses to the DNA strand-scission enediyne C-1027 can be independent of ATM, ATR, and DNA-PK kinases.
The Journal of biological chemistry 2002;277(23):20549-54.
2002: White Christine M; Satz Alexander L; Gawron Loretta S; Bruice Thomas C; Beerman Terry A
Inhibiting transcription factor/DNA complexes using fluorescent microgonotropens (FMGTs).
Biochimica et biophysica acta 2002;1574(1):100-8.
2001: Liu J S; Kuo S R; Yin X; Beerman T A; Melendy T
DNA damage by the enediyne C-1027 results in the inhibition of DNA replication by loss of replication protein A function and activation of DNA-dependent protein kinase.
Biochemistry 2001;40(48):14661-8.
2001: White C M; Satz A L; Bruice T C; Beerman T A
Inhibition of transcription factor-DNA complexes and gene expression by a microgonotropen.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10590-5.
2001: Satz A L; White C M; Beerman T A; Bruice T C
Double-stranded DNA binding characteristics and subcellular distribution of a minor groove binding diphenyl ether bisbenzimidazole.
Biochemistry 2001;40(21):6465-74.
2001: Wang Y; Beerman T A; Kowalski D
Antitumor drug adozelesin differentially affects active and silent origins of DNA replication in yeast checkpoint kinase mutants.
Cancer research 2001;61(9):3787-94.
2001: McHugh M M; Yin X; Kuo S R; Liu J S; Melendy T; Beerman T A
The cellular response to DNA damage induced by the enediynes C-1027 and neocarzinostatin includes hyperphosphorylation and increased nuclear retention of replication protein a (RPA) and trans inhibition of DNA replication.
Biochemistry 2001;40(15):4792-9.
2001: Dziegielewski J; Melendy T; Beerman T A
Bleomycin-induced alterations in DNA replication: relationship to DNA damage.
Biochemistry 2001;40(3):704-11.
2000: White C M; Heidenreich O; Nordheim A; Beerman T A
Evaluation of the effectiveness of DNA-binding drugs to inhibit transcription using the c-fos serum response element as a target.
Biochemistry 2000;39(40):12262-73.
2000: Chiang S Y; Burli R W; Benz C C; Gawron L; Scott G K; Dervan P B; Beerman T A
Targeting the ets binding site of the HER2/neu promoter with pyrrole-imidazole polyamides.
The Journal of biological chemistry 2000;275(32):24246-54.
2000: Liu J S; Kuo S R; McHugh M M; Beerman T A; Melendy T
Adozelesin triggers DNA damage response pathways and arrests SV40 DNA replication through replication protein A inactivation.
The Journal of biological chemistry 2000;275(2):1391-7.
1999: McHugh M M; Kuo S R; Walsh-O'Beirne M H; Liu J S; Melendy T; Beerman T A
Bizelesin, a bifunctional cyclopropylpyrroloindole alkylating agent, inhibits simian virus 40 replication in trans by induction of an inhibitor.
Biochemistry 1999;38(35):11508-15.
1999: McHugh M M; Beerman T A
C-1027-induced alterations in Epstein-Barr viral DNA replication in latently infected cultured human Raji cells: relationship to DNA damage.
Biochemistry 1999;38(21):6962-70.
1999: McHugh M M; Beerman T A
Purification of large quantities of high-molecular-weight Epstein-Barr viral and cellular genomic DNA from cultured human Raji cells.
BioTechniques 1999;26(2):188-90, 192, 194.
1998: Chiang S Y; Azizkhan J C; Beerman T A
A comparison of DNA-binding drugs as inhibitors of E2F1- and Sp1-DNA complexes and associated gene expression.
Biochemistry 1998;37(9):3109-15.
1997: Woynarowski J M; Beerman T A
Effects of bizelesin (U-77,779), a bifunctional alkylating minor groove binder, on replication of genomic and simian virus 40 DNA in BSC-1 cells.
Biochimica et biophysica acta 1997;1353(1):50-60.
1997: Tatarowicz W A; Martin C E; Pekosz A S; Madden S L; Rauscher F J; Chiang S Y; Beerman T A; Fraser N W
Repression of the HSV-1 latency-associated transcript (LAT) promoter by the early growth response (EGR) proteins: involvement of a binding site immediately downstream of the TATA box.
Journal of neurovirology 1997;3(3):212-24.
1997: Bruice T C; Sengupta D; Blaskó A; Chiang S Y; Beerman T A
A microgonotropen branched decaaza decabutylamine and its DNA and DNA/transcription factor interactions.
Bioorganic & medicinal chemistry 1997;5(4):685-92.
1997: Chiang S Y; Bruice T C; Azizkhan J C; Gawron L; Beerman T A
Targeting E2F1-DNA complexes with microgonotropen DNA binding agents.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2811-6.
1997: McHugh M M; Beerman T A; Burhans W C
DNA-damaging enediyne C-1027 inhibits initiation of intracellular SV40 DNA replication in trans.
Biochemistry 1997;36(5):1003-9.
1997: Kirk C A; Goodisman J; Beerman T A; Gawron L S; Dabrowiak J C
Kinetics of cleavage of intra- and extracellular simian virus 40 DNA with the enediyne anticancer drug C-1027.
Biophysical chemistry 1997;63(2-3):201-9.
1996: Chiang S Y; Welch J J; Rauscher F J; Beerman T A
Effect of DNA-binding drugs on early growth response factor-1 and TATA box-binding protein complex formation with the herpes simplex virus latency promoter.
The Journal of biological chemistry 1996;271(39):23999-4004.
1996: Cobuzzi R J; Burhans W C; Beerman T A
Inhibition of initiation of simian virus 40 DNA replication in infected BSC-1 cells by the DNA alkylating drug adozelesin.
The Journal of biological chemistry 1996;271(33):19852-9.
1995: Woynarowski J M; McHugh M M; Gawron L S; Beerman T A
Effects of bizelesin (U-77779), a bifunctional alkylating minor groove agent, on genomic and simian virus 40 DNA.
Biochemistry 1995;34(40):13042-50.
1995: McHugh M M; Woynarowski J M; Gawron L S; Otani T; Beerman T A
Effects of the DNA-damaging enediyne C-1027 on intracellular SV40 and genomic DNA in green monkey kidney BSC-1 cells.
Biochemistry 1995;34(5):1805-14.
1995: Cobuzzi R J; Kotsopoulos S K; Otani T; Beerman T A
Effects of the enediyne C-1027 on intracellular DNA targets.
Biochemistry 1995;34(2):583-92.
1994: Welch J J; Rauscher F J; Beerman T A
Targeting DNA-binding drugs to sequence-specific transcription factor.DNA complexes. Differential effects of intercalating and minor groove binding drugs.
The Journal of biological chemistry 1994;269(49):31051-8.
1994: McHugh M M; Woynarowski J M; Mitchell M A; Gawron L S; Weiland K L; Beerman T A
CC-1065 bonding to intracellular and purified SV40 DNA: site specificity and functional effects.
Biochemistry 1994;33(31):9158-68.
1994: Johnson P G; Beerman T A
Damage induced in episomal EBV DNA in Raji cells by antitumor drugs as measured by pulsed field gel electrophoresis.
Analytical biochemistry 1994;220(1):103-14.
1994: Chiang S Y; Welch J; Rauscher F J; Beerman T A
Effects of minor groove binding drugs on the interaction of TATA box binding protein and TFIIA with DNA.
Biochemistry 1994;33(23):7033-40.
1994: Woynarowski J M; McCarthy K; Reynolds B; Beerman T A; Denny W A
Topoisomerase II mediated DNA lesions induced by acridine-4-carboxamide and 2-(4-pyridyl)quinoline-8-carboxamide.
Anti-cancer drug design 1994;9(1):9-24.
1992: Beerman T A; McHugh M M; Sigmund R; Lown J W; Rao K E; Bathini Y
Effects of analogs of the DNA minor groove binder Hoechst 33258 on topoisomerase II and I mediated activities.
Biochimica et biophysica acta 1992;1131(1):53-61.
1992: Zsido T J; Beerman T A; Meegan R L; Woynarowski J M; Baker R M
Resistance of CHO cells expressing P-glycoprotein to cyclopropylpyrroloindole (CPI) alkylating agents.
Biochemical pharmacology 1992;43(8):1817-22.
1991: Beerman T A; Woynarowski J M; Sigmund R D; Gawron L S; Rao K E; Lown J W
Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes.
Biochimica et biophysica acta 1991;1090(1):52-60.
1991: Ferrazzi E; Woynarowski J M; Arakali A; Brenner D E; Beerman T A
DNA damage and cytotoxicity induced by metabolites of anthracycline antibiotics, doxorubicin and idarubicin.
Cancer communications 1991;3(6):173-80.
1991: Vertino P M; Beerman T A; Kelly E J; Bergeron R J; Porter C W
Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function.
Molecular pharmacology 1991;39(4):487-94.
1991: Zsido T J; Woynarowski J M; Baker R M; Gawron L S; Beerman T A
Induction of heat-labile sites in DNA of mammalian cells by the antitumor alkylating drug CC-1065.
Biochemistry 1991;30(15):3733-8.
1991: Cullinan E B; Gawron L S; Rustum Y M; Beerman T A
Extrachromosomal chromatin: novel target for bleomycin cleavage in cells and solid tumors.
Biochemistry 1991;30(12):3055-61.
1990: Cullinan E B; Gawron L S; Rustum Y M; Beerman T A
Topoisomerase II-mediated DNA damage of episomes in tumor-bearing mice.
Cancer research 1990;50(19):6154-7.
1990: Rauscher F J; Beerman T A; Baker R M
Characterization of auromomycin-resistant hamster cell mutants that display a multidrug resistance phenotype.
Molecular pharmacology 1990;38(2):198-206.
1990: McHugh M M; Sigmund R D; Beerman T A
Effects of minor groove binding drugs on camptothecin-induced DNA lesions in L1210 nuclei.
Biochemical pharmacology 1990;39(4):707-14.
1989: Woynarowski J M; McNamee H; Szmigiero L; Beerman T A; Konopa J
Induction of DNA-protein crosslinks by antitumor 1-nitro-9-aminoacridines in L1210 leukemia cells.
Biochemical pharmacology 1989;38(22):4095-101.
1989: Cullinan E B; Beerman T A
A study of drug-induced topoisomerase II-mediated DNA lesions on episomal chromatin.
The Journal of biological chemistry 1989;264(27):16268-75.
1989: McHugh M M; Woynarowski J M; Sigmund R D; Beerman T A
Effect of minor groove binding drugs on mammalian topoisomerase I activity.
Biochemical pharmacology 1989;38(14):2323-8.
1989: Woynarowski J M; Sigmund R D; Beerman T A
DNA minor groove binding agents interfere with topoisomerase II mediated lesions induced by epipodophyllotoxin derivative VM-26 and acridine derivative m-AMSA in nuclei from L1210 cells.
Biochemistry 1989;28(9):3850-5.
1989: Beckmann R P; Beerman T A
Use of an inducible hybrid viral gene as a model for evaluating drug effects on gene expression.
Molecular pharmacology 1989;35(4):433-42.
1989: Woynarowski J M; McHugh M; Sigmund R D; Beerman T A
Modulation of topoisomerase II catalytic activity by DNA minor groove binding agents distamycin, Hoechst 33258, and 4',6-diamidine-2-phenylindole.
Molecular pharmacology 1989;35(2):177-82.
1989: Woynarowski J M; Beerman T A
Preferential effect of bleomycin on newly replicated chromatin in nuclei from L1210 cells.
Biochimica et biophysica acta 1989;1007(1):116-9.
1988: Grimwade J E; Cullinan E B; Beerman T A
Neocarzinostatin and auromomycin preferentially cleave simian virus 40 DNA and chromosomes at a number of discrete locations.
Biochimica et biophysica acta 1988;950(2):102-12.
1988: Woynarowski J M; Sigmund R D; Beerman T A
Topoisomerase-II-mediated lesions in nascent DNA: comparison of the effects of epipodophyllotoxin derivatives, VM-26 and VP-16, and 9-anilinoacridine derivatives, m-AMSA and o-AMSA.
Biochimica et biophysica acta 1988;950(1):21-9.
1987: Woynarowski J M; Gawron L S; Beerman T A
Bleomycin-induced aggregation of presolubilized and nuclear chromatin from L1210 cells.
Biochimica et biophysica acta 1987;910(2):149-56.
1987: Beckmann R P; Agostino M J; McHugh M M; Sigmund R D; Beerman T A
Assessment of preferential cleavage of an actively transcribed retroviral hybrid gene in murine cells by deoxyribonuclease I, bleomycin, neocarzinostatin, or ionizing radiation.
Biochemistry 1987;26(17):5409-15.
1987: Grimwade J E; Cason E B; Beerman T A
Site specificity of bleomycin cleavage in purified and intracellular simian virus 40 DNA.
Nucleic acids research 1987;15(16):6315-29.
1986: Grimwade J E; Beerman T A
Measurement of bleomycin, neocarzinostatin, and auromomycin cleavage of cell-free and intracellular simian virus 40 DNA and chromatin.
Molecular pharmacology 1986;30(4):358-63.
1984: Agostino M J; Bernacki R J; Beerman T A
Synergistic interactions of ethidium bromide and bleomycin on cellular DNA and growth inhibition.
Biochemical and biophysical research communications 1984;120(1):156-63.
1983: Rauscher F; Mueller G; Beerman T
The effects of the antitumor protein auromomycin on HeLa S3 nuclei. Release of soluble chromatin.
Molecular pharmacology 1983;24(1):97-102.
1983: Beerman T A; Mueller G; Grimmond H
Effects of neocarzinostatin on chromatin in HeLa S3 nuclei.
Molecular pharmacology 1983;23(2):493-9.
1982: Rauscher F; Mueller G; McHugh M; Beerman T
Degradation of HelA S3 cell chromatin by auromomycin and its chromophore.
Biochemical and biophysical research communications 1982;108(1):355-62.
1982: McHugh M M; Woynarowski J; Beerman T
Degradation of HeLa cell chromatin by neocarzinostatin and its chromophore.
Biochimica et biophysica acta 1982;696(1):7-14.
1981: Woynarowski J W; Beerman T A; Konopa J
Induction of deoxyribonucleic acid damage in HeLa S3 cells by cytotoxic and antitumor sesquiterpene lactones.
Biochemical pharmacology 1981;30(21):3005-7.
1980: Woynarowski J M; Beerman T A
Inhibition of DNA replication in HeLa S3 cells by macromomycin-I, an antitumor protein antibiotic.
Molecular pharmacology 1980;18(3):491-6.
1980: Woynarowski J M; Beerman T A
Purification and characterization of macromomycin-I, a protein antibiotic containing a non-protein chromophore.
Biochemical and biophysical research communications 1980;94(3):769-76.

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