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Yoshihiro Morishima

Research Profile

Chemicals & Drugs

Anatomy

Phenomena

Living Beings

Concepts & Ideas

Drug Dose Response Relationship

Physiology

Protein Folding

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Publications

TOP 3
Adrienne M Wang; Jason P Chua; Catherine A Collins; Jason E Gestwicki; Susan Klinedinst; Tomoko Komiyama; Xiaokai Li; Diane E Merry; Yoshinari Miyata; Yoshihiro Morishima; Yoichi Osawa; Hwei-Ming Peng; William B Pratt; Andrew P Lieberman
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.
Kelly M Clapp; Michael J Ford; Gary J Jenkins; Miranda Lau; Yoshihiro Morishima; Hwei-Ming Peng; Yoichi Osawa
Ubiquitination of neuronal nitric-oxide synthase in the calmodulin-binding site triggers proteasomal degradation of the protein.
Hwei-Ming Peng; William B Pratt; Yoshihiro Morishima; Yoichi Osawa
Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination.

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All Publications

2013: Adrienne M Wang; Jason P Chua; Catherine A Collins; Jason E Gestwicki; Susan Klinedinst; Tomoko Komiyama; Xiaokai Li; Diane E Merry; Yoshinari Miyata; Yoshihiro Morishima; Yoichi Osawa; Hwei-Ming Peng; William B Pratt; Andrew P Lieberman
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.
Nature chemical biology 2013;9(2):112-8.
2012: Kelly M Clapp; Michael J Ford; Gary J Jenkins; Miranda Lau; Yoshihiro Morishima; Hwei-Ming Peng; Yoichi Osawa
Ubiquitination of neuronal nitric-oxide synthase in the calmodulin-binding site triggers proteasomal degradation of the protein.
The Journal of biological chemistry 2012;287(51):42601-10.
2012: Hwei-Ming Peng; William B Pratt; Yoshihiro Morishima; Yoichi Osawa
Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination.
The Journal of biological chemistry 2012;287(2):1556-65.
2011: Yoshihiro Morishima; Jason E Gestwicki; Miranda Lau; Yoshinari Miyata; Hwei-Ming Peng; William B Pratt; Yoichi Osawa
Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft.
Biochemistry 2011;50(33):7146-56.
2010: Kelly M Clapp; Hwei-Ming Peng; Yoshihiro Morishima; Miranda Lau; Vyvyca J Walker; William B Pratt; Yoichi Osawa
C331A mutant of neuronal nitric-oxide synthase is labilized for Hsp70/CHIP (C terminus of HSC70-interacting protein)-dependent ubiquitination.
The Journal of biological chemistry 2010;285(44):33642-51.
2010: Adrienne M Wang; Yoshihiro Morishima; Kelly M Clapp; Hwei-Ming Peng; William B Pratt; Jason E Gestwicki; Yoichi Osawa; Andrew P Lieberman
Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.
The Journal of biological chemistry 2010;285(21):15714-23.
2010: William B Pratt; Yoshihiro Morishima; Hwei-Ming Peng; Yoichi Osawa
Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage.
Experimental biology and medicine (Maywood, N.J.) 2010;235(3):278-89.
2009: Hwei-Ming Peng; Yoshihiro Morishima; Kelly M Clapp; Miranda Lau; William B Pratt; Yoichi Osawa
Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination.
Biochemistry 2009;48(35):8483-90.
2009: Tomoka Furukawa; Kanako Wakabayashi; Ai Tamura; Hiroshi Nakagawa; Yoshihiro Morishima; Yoichi Osawa; Toshihisa Ishikawa
Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations.
Pharmaceutical research 2009;26(2):469-79.
2008: Yoshihiro Morishima; Adrienne M Wang; Zhigang Yu; William B Pratt; Yoichi Osawa; Andrew P Lieberman
CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins.
Human molecular genetics 2008;17(24):3942-52.
2008: William B Pratt; Yoshihiro Morishima; Yoichi Osawa
The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts.
The Journal of biological chemistry 2008;283(34):22885-9.
2006: Monzy Thomas; Jennifer M Harrell; Yoshihiro Morishima; Hwei-Ming Peng; William B Pratt; Andrew P Lieberman
Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction.
Human molecular genetics 2006;15(11):1876-83.
2006: William B Pratt; Yoshihiro Morishima; M Murphy; M Harrell
Chaperoning of glucocorticoid receptors.
Handbook of experimental pharmacology 2006;(172):111-38.
2005: Yoshihiro Morishima; Hwei-Ming Peng; Hsia-lien Lin; Paul Hollenberg; Roger K Sunahara; Yoichi Osawa; William B Pratt
Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation.
Biochemistry 2005;44(49):16333-40.
2005: Patrick J M Murphy; Yoshihiro Morishima; Jeffrey J Kovacs; Tso-Pang Yao; William B Pratt
Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone.
The Journal of biological chemistry 2005;280(40):33792-9.
2004: Mario D Galigniana; Yoshihiro Morishima; Philippe A Gallay; William B Pratt
Cyclophilin-A is bound through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex.
The Journal of biological chemistry 2004;279(53):55754-9.
2004: Jennifer M Harrell; Patrick J M Murphy; Yoshihiro Morishima; Haifeng Chen; John F Mansfield; Mario D Galigniana; William B Pratt
Evidence for glucocorticoid receptor transport on microtubules by dynein.
The Journal of biological chemistry 2004;279(52):54647-54.
2004: Hwei-Ming Peng; Yoshihiro Morishima; Gary J Jenkins; Anwar Y Dunbar; Miranda Lau; Winston Patterson; William B Pratt; Yoichi Osawa
Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.
The Journal of biological chemistry 2004;279(51):52970-7.
2004: Scott S Billecke; Dragomir I Draganov; Yoshihiro Morishima; Patrick J M Murphy; Anwar Y Dunbar; William B Pratt; Yoichi Osawa
The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase.
The Journal of biological chemistry 2004;279(29):30252-8.
2004: Patrick J M Murphy; Mario D Galigniana; Yoshihiro Morishima; Jennifer M Harrell; Roland P S Kwok; Mats Ljungman; William B Pratt
Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation.
The Journal of biological chemistry 2004;279(29):30195-201.
2004: William B Pratt; Mario D Galigniana; Yoshihiro Morishima; Patrick J M Murphy
Role of molecular chaperones in steroid receptor action.
Essays in biochemistry 2004;40():41-58.
2003: Yoshihiro Morishima; Kimon C Kanelakis; Patrick J M Murphy; Ezra R Lowe; Gary J Jenkins; Yoichi Osawa; Roger K Sunahara; William B Pratt
The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex.
The Journal of biological chemistry 2003;278(49):48754-63.
2003: Patrick J M Murphy; Yoshihiro Morishima; Haifeng Chen; Mario D Galigniana; John F Mansfield; S Stoney Simons; William B Pratt
Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft.
The Journal of biological chemistry 2003;278(37):34764-73.
2002: Yinna Wang; Zhenyu Zhu; Tadayoshi Hasuma; Yoshihisa Yano; Yoshihiro Morishima; Isao Matsui-Yuasa; Shuzo Otani
Modulation of ornithine decarboxylase activity and mitogen-activated protein kinases in protocatechualdehyde-induced apoptosis of CTLL-2 cells.
Anticancer research 2002;22(6A):3389-94.
2001: Patrick J M Murphy; Kimon C Kanelakis; Mario D Galigniana; Yoshihiro Morishima; William B Pratt
Stoichiometry, abundance, and functional significance of the hsp90/hsp70-based multiprotein chaperone machinery in reticulocyte lysate.
The Journal of biological chemistry 2001;276(32):30092-8.
2001: Yinna Wang; Tadayoshi Hasuma; Yoshihisa Yano; Yoshihiro Morishima; Isao Matsui-Yuasa; Shuzo Otani
Induction of apoptosis in CTLL-2 cells by protocatechualdehyde.
Anticancer research 2001;21(2A):1095-101.
2001: Yoshihiro Morishima; Kimon C Kanelakis; Patrick J M Murphy; Donna S Shewach; William B Pratt
Evidence for iterative ratcheting of receptor-bound hsp70 between its ATP and ADP conformations during assembly of glucocorticoid receptor.hsp90 heterocomplexes.
Biochemistry 2001;40(4):1109-16.
2000: Kimon C Kanelakis; Patrick J M Murphy; Mario D Galigniana; Yoshihiro Morishima; S Takayama; J C Reed; David O Toft; William B Pratt
hsp70 interacting protein Hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1.
Biochemistry 2000;39(46):14314-21.
2000: Yoshihiro Morishima; Patrick J M Murphy; D P Li; Edwin Ramon Sanchez; William B Pratt
Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket.
The Journal of biological chemistry 2000;275(24):18054-60.
2000: Yutaka Furumitsu; Kazuhiko Yukioka; Masao Yukioka; Takahiro Ochi; Yoshihiro Morishima; I Matsui-Yuasa; S Otani; Masaaki Inaba; Yoshiki Nishizawa; Hirotoshi Morii
Interleukin-1beta induces elevation of spermidine/spermine N1-acetyltransferase activity and an increase in the amount of putrescine in synovial adherent cells from patients with rheumatoid arthritis.
The Journal of rheumatology 2000;27(6):1352-7.
2000: Yoshihiro Morishima; Kimon C Kanelakis; AM Silverstein; KD Dittmar; Lourdes Estrada; William B Pratt
The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system.
The Journal of biological chemistry 2000;275(10):6894-900.
1999: Kimon C Kanelakis; Yoshihiro Morishima; KD Dittmar; Mario D Galigniana; S Takayama; J C Reed; William B Pratt
Differential effects of the hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the hsp90-based chaperone machinery.
The Journal of biological chemistry 1999;274(48):34134-40.
1997: X Chen; Tadayoshi Hasuma; Yoshihisa Yano; T Yoshimata; Yoshihiro Morishima; Yinna Wang; Shuzo Otani
Inhibition of farnesyl protein transferase by monoterpene, curcumin derivatives and gallotannin.
Anticancer research 1997;17(4A):2555-64.
1997: E M Youssef; Tadayoshi Hasuma; Yoshihiro Morishima; Nobuyasu Takada; Harushi Osugi; M Higashino; Shuzo Otani; Shoji Fukushima
Overexpression of cyclin D1 in rat esophageal carcinogenesis model.
Japanese journal of cancer research : Gann 1997;88(1):18-25.
1994: Yoshihiro Morishima; Masaaki Inaba; Yoshiki Nishizawa; Hirotoshi Morii; Tadayoshi Hasuma; Isao Matsui-Yuasa; Shuzo Otani
The involvement of polyamines in the activation of vitamin D receptor from porcine intestinal mucosa.
European journal of biochemistry / FEBS 1994;219(1-2):349-56.
1992: Kiyoshi Nakatsuka; Y Imanishi; Yoshihiro Morishima; K Sekiya; K Sasao; Takami Miki; Yoshiki Nishizawa; T Katsumata; A Nagata; S Murakawa
Biological potency of a fluorinated vitamin D analogue in hypoparathyroidism.
Bone and mineral 1992;16(1):73-81.