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Ryuichi Morishita

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Procedures

Gene Therapy

Chemicals & Drugs

Living Beings

Physiology

Devices

Gene Transfer Techniques

Anatomy

Disorders

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Publications

TOP 3
Sanada Fumihiro; Taniyama Yoshiaki; Iekushi Kazuma; Azuma Junya; Okayama Keita; Kusunoki Hiroshi; Koibuchi Nobutaka; Doi Takefumi; Aizawa Yoshifusa; Morishita Ryuichi
Negative action of hepatocyte growth factor/c-Met system on angiotensin II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells.
Shimizu Hideo; Nakagami Hironori; Osako Mariana Kiomy; Nakagami Futoshi; Kunugiza Yasuo; Tomita Tetsuya; Yoshikawa Hideki; Rakugi Hiromi; Ogihara Toshio; Morishita Ryuichi
Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats.
Morishita Ryuichi; Ishii Junichi; Kusumi Yoshiaki; Yamada Shingo; Komai Norio; Ohishi Minoru; Nomura Masanori; Hishida Hitoshi; Niihashi Mari; Mitsumata Masako
Association of serum oxidized lipoprotein(a) concentration with coronary artery disease: potential role of oxidized lipoprotein(a) in the vasucular wall.

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All Publications

2009: Sanada Fumihiro; Taniyama Yoshiaki; Iekushi Kazuma; Azuma Junya; Okayama Keita; Kusunoki Hiroshi; Koibuchi Nobutaka; Doi Takefumi; Aizawa Yoshifusa; Morishita Ryuichi
Negative action of hepatocyte growth factor/c-Met system on angiotensin II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells.
Circulation research 2009;105(7):667-75, 13 p following 675.
2009: Shimizu Hideo; Nakagami Hironori; Osako Mariana Kiomy; Nakagami Futoshi; Kunugiza Yasuo; Tomita Tetsuya; Yoshikawa Hideki; Rakugi Hiromi; Ogihara Toshio; Morishita Ryuichi
Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(9):786-90.
2009: Morishita Ryuichi; Ishii Junichi; Kusumi Yoshiaki; Yamada Shingo; Komai Norio; Ohishi Minoru; Nomura Masanori; Hishida Hitoshi; Niihashi Mari; Mitsumata Masako
Association of serum oxidized lipoprotein(a) concentration with coronary artery disease: potential role of oxidized lipoprotein(a) in the vasucular wall.
Journal of atherosclerosis and thrombosis 2009;16(4):410-8.
2009: Katsuya Tomohiro; Morishita Ryuichi; Rakugi Hiromi; Ogihrara Toshio
Genetic basis of hypertension for the development of tailored medicine.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(8):643-8.
2009: Miyake Takashi; Morishita Ryuichi
Pharmacological treatment of abdominal aortic aneurysm.
Cardiovascular research 2009;83(3):436-43.
2009: Nakagami Hironori; Morishita Ryuichi
[Gene therapy for anti-aging medicine]
Nippon rinsho. Japanese journal of clinical medicine 2009;67(7):1407-11.
2009: Katsuya Tomohiro; Morishita Ryuichi
[WRN gene]
Nippon rinsho. Japanese journal of clinical medicine 2009;67(7):1277-82.
2009: Nakagami Hironori; Morishita Ryuichi
[Hormones and osteoporosis update. Effect of angiotensin II on bone metabolism]
Clinical calcium 2009;19(7):997-1002.
2009: Takeda Shuko; Sato Naoyuki; Niisato Kazue; Takeuchi Daisuke; Kurinami Hitomi; Shinohara Mitsuru; Rakugi Hiromi; Kano Masanobu; Morishita Ryuichi
Validation of Abeta1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease.
Brain research 2009;1280():137-47.
2009: Takeda Shuko; Sato Naoyuki; Uchio-Yamada Kozue; Sawada Kyoko; Kunieda Takanori; Takeuchi Daisuke; Kurinami Hitomi; Shinohara Mitsuru; Rakugi Hiromi; Morishita Ryuichi
Elevation of plasma beta-amyloid level by glucose loading in Alzheimer mouse models.
Biochemical and biophysical research communications 2009;385(2):193-7.
2009: Mori Masaki; Nakagami Hironori; Koibuchi Nobutaka; Miura Koichi; Takami Yoichi; Koriyama Hiroshi; Hayashi Hiroki; Sabe Hisataka; Mochizuki Naoki; Morishita Ryuichi; Kaneda Yasufumi
Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis.
Molecular biology of the cell 2009;20(13):3115-24.
2009: Hayashi Hiroki; Nakagami Hironori; Takami Yoichi; Koriyama Hiroshi; Mori Masaki; Tamai Katsuto; Sun Jianxin; Nagao Kaori; Morishita Ryuichi; Kaneda Yasufumi
FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(6):909-14.
2009: Nakagami Hironori; Osako Mariana Kiomy; Takami Yoichi; Hanayama Rie; Koriyama Hiroshi; Mori Masaki; Hayashi Hiroki; Shimizu Hideo; Morishita Ryuichi
Vascular protective effects of ezetimibe in ApoE-deficient mice.
Atherosclerosis 2009;203(1):51-8.
2009: Nishikawa Tomoyuki; Nakagami Hironori; Maeda Akito; Morishita Ryuichi; Miyazaki Nobuhiko; Ogawa Toshihiro; Tabata Yasuhiko; Kikuchi Yasushi; Hayashi Hiroki; Tatsu Yoshiro; Yumoto Noboru; Tamai Katsuto; Tomono Kazunori; Kaneda Yasufumi
Development of a novel antimicrobial peptide, AG-30, with angiogenic properties.
Journal of cellular and molecular medicine 2009;13(3):535-46.
2009: Suzuki Jun-Ichi; Tezuka Daisuke; Morishita Ryuichi; Isobe Mitsuaki
An initial case of suppressed restenosis with nuclear factor-kappa B decoy transfection after percutaneous coronary intervention.
The journal of gene medicine 2009;11(1):89-91.
2009: Suzuki Jun-ichi; Isobe Mitsuaki; Morishita Ryuichi; Nagai Ryozo
Tea polyphenols regulate key mediators on inflammatory cardiovascular diseases.
Mediators of inflammation 2009;2009():494928.
2008: Fujiwara Yoshikazu; Shiraya Suguru; Miyake Takashi; Yamakawa Satoshi; Aoki Motokuni; Makino Hirofumi; Nishimura Motonobu; Morishita Ryuichi
Inhibition of experimental abdominal aortic aneurysm in a rat model by the angiotensin receptor blocker valsartan.
International journal of molecular medicine 2008;22(6):703-8.
2008: Wakayama Kouji; Shimamura Munehisa; Sata Masataka; Koibuchi Nobutaka; Sato Naoyuki; Ogihara Toshio; Morishita Ryuichi
A model of cerebrovascular injury in rats.
Journal of neuroscience methods 2008;175(2):187-95.
2008: Miyake Takashi; Aoki Motokuni; Morishita Ryuichi
Inhibition of anastomotic intimal hyperplasia using a chimeric decoy strategy against NFkappaB and E2F in a rabbit model.
Cardiovascular research 2008;79(4):706-14.
2008: Shimizu Hideo; Nakagami Hironori; Osako Mariana Kiomy; Hanayama Rie; Kunugiza Yasuo; Kizawa Takuji; Tomita Tetsuya; Yoshikawa Hideki; Ogihara Toshio; Morishita Ryuichi
Angiotensin II accelerates osteoporosis by activating osteoclasts.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(7):2465-75.
2008: Kurinami Hitomi; Sato Naoyuki; Shinohara Mitsuru; Takeuchi Daisuke; Takeda Shuko; Shimamura Munehisa; Ogihara Toshio; Morishita Ryuichi
Prevention of amyloid beta-induced memory impairment by fluvastatin, associated with the decrease in amyloid beta accumulation and oxidative stress in amyloid beta injection mouse model.
International journal of molecular medicine 2008;21(5):531-7.
2008: Nagao Kaori; Taniyama Yoshiaki; Kietzmann Thomas; Doi Takefumi; Komuro Issei; Morishita Ryuichi
HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus.
The Journal of biological chemistry 2008;283(17):11841-9.
2008: Takeuchi D; Sato N; Shimamura M; Kurinami H; Takeda S; Shinohara M; Suzuki S; Kojima M; Ogihara T; Morishita R
Alleviation of Abeta-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model.
Gene therapy 2008;15(8):561-71.
2008: Saito Y; Nakagami H; Kurooka M; Takami Y; Kikuchi Y; Hayashi H; Nishikawa T; Tamai K; Morishita R; Azuma N; Sasajima T; Kaneda Y
Cold shock domain protein A represses angiogenesis and lymphangiogenesis via inhibition of serum response element.
Oncogene 2008;27(13):1821-33.
2008: Tomita Naruya; Yamasaki Keita; Izawa Keiko; Kunugiza Yasuo; Osako Mariana K; Ogihara Toshio; Morishita Ryuichi
Inhibition of experimental abdominal aortic aneurysm progression by nifedipine.
International journal of molecular medicine 2008;21(2):239-44.
2008: Takeda Shuko; Sato Naoyuki; Ogihara Toshio; Morishita Ryuichi
The renin-angiotensin system, hypertension and cognitive dysfunction in Alzheimer's disease: new therapeutic potential.
Frontiers in bioscience : a journal and virtual library 2008;13():2253-65.
2007: Nakagami Hironori; Kikuchi Yasushi; Katsuya Tomohiro; Morishita Ryuichi; Akasaka Hiroshi; Saitoh Shigeyuki; Rakugi Hiromi; Kaneda Yasufumi; Shimamoto Kazuaki; Ogihara Toshio
Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(12):1239-46.
2007: Shimamura Munehisa; Sato Naoyuki; Sata Masataka; Kurinami Hitomi; Takeuchi Daisuke; Wakayama Kouji; Hayashi Takuya; Iida Hidehiro; Morishita Ryuichi
Delayed postischemic treatment with fluvastatin improved cognitive impairment after stroke in rats.
Stroke; a journal of cerebral circulation 2007;38(12):3251-8.
2007: Hayashi Hiroki; Nakagami Hironori; Takami Yoichi; Sato Naoyuki; Saito Yukihiro; Nishikawa Tomoyuki; Mori Masaki; Koriyama Hiroshi; Tamai Katsuto; Morishita Ryuichi; Kaneda Yasufumi
Involvement of gamma-secretase in postnatal angiogenesis.
Biochemical and biophysical research communications 2007;363(3):584-90.
2007: Miyake Takashi; Aoki Motokuni; Masaki Hisao; Kawasaki Tomio; Oishi Masako; Kataoka Kazusaburo; Ogihara Toshio; Kaneda Yasufumi; Morishita Ryuichi
Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappaB and ets in a rabbit model.
Circulation research 2007;101(11):1175-84.
2007: Takami Yoichi; Nakagami Hironori; Morishita Ryuichi; Katsuya Tomohiro; Cui Tai-Xing; Ichikawa Tomonaga; Saito Yukihiro; Hayashi Hiroki; Kikuchi Yasushi; Nishikawa Tomoyuki; Baba Yoshichika; Yasuda Osamu; Rakugi Hiromi; Ogihara Toshio; Kaneda Yasufumi
Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(10):2184-90.
2007: Taniguchi Hirokazu; Fujiwara Yoshiyuki; Doki Yuichiro; Sugita Yurika; Sohma Itsuro; Miyata Hiroshi; Takiguchi Shuji; Yasuda Takushi; Tomita Naruya; Morishita Ryuichi; Monden Morito
Gene therapy using ets-1 transcription factor decoy for peritoneal dissemination of gastric cancer.
International journal of cancer. Journal international du cancer 2007;121(7):1609-17.
2007: Osako Mariana Kiomy; Tomita Naruya; Nakagami Hironori; Kunugiza Yasuo; Yoshino Masafumi; Yuyama Kazuhiko; Tomita Tetsuya; Yoshikawa Hideki; Ogihara Toshio; Morishita Ryuichi
Increase in nuclease resistance and incorporation of NF-kappaB decoy oligodeoxynucleotides by modification of the 3'-terminus.
The journal of gene medicine 2007;9(9):812-9.
2007: Nagao Kaori; Taniyama Yoshiaki; Koibuchi Nobutaka; Morishita Ryuichi
Constitutive over-expression of VEGF results in reduced expression of Hand-1 during cardiac development in Xenopus.
Biochemical and biophysical research communications 2007;359(3):431-7.
2007: Iekushi Kazuma; Taniyama Yoshiaki; Azuma Junya; Katsuragi Naruto; Dosaka Norio; Sanada Fumihiro; Koibuchi Nobutaka; Nagao Kaori; Ogihara Toshio; Morishita Ryuichi
Novel mechanisms of valsartan on the treatment of acute myocardial infarction through inhibition of the antiadhesion molecule periostin.
Hypertension 2007;49(6):1409-14.
2007: Shimamura Munehisa; Sato Naoyuki; Sata Masataka; Wakayama Kouji; Ogihara Toshio; Morishita Ryuichi
Expression of hepatocyte growth factor and c-Met after spinal cord injury in rats.
Brain research 2007;1151():188-94.
2007: Tomita Naruya; Yamasaki Keita; Izawa Keiko; Kunugiza Yasuo; Osako Mariana K; Ogihara Toshio; Morishita Ryuichi
Improvement of organ damage by a non-depressor dose of imidapril in diabetic spontaneously hypertensive rats.
International journal of molecular medicine 2007;19(4):571-9.
2007: Tomita Naruya; Kashihara Naoki; Morishita Ryuichi
Transcription factor decoy oligonucleotide-based therapeutic strategy for renal disease.
Clinical and experimental nephrology 2007;11(1):7-17.
2007: Wakayama Kouji; Shimamura Munehisa; Sata Masataka; Sato Naoyuki; Kawakami Koji; Fukuda Hirotsugu; Tomimatsu Takuji; Ogihara Toshio; Morishita Ryuichi
Quantitative measurement of neurological deficit after mild (30 min) transient middle cerebral artery occlusion in rats.
Brain research 2007;1130(1):181-7.
2006: Koike H; Ishida A; Shimamura M; Mizuno S; Nakamura T; Ogihara T; Kaneda Y; Morishita R
Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease.
Gene therapy 2006;13(23):1639-44.
2006: Ozaki Kazunari; Morishita Ryuichi; Ogihara Toshio
[Overview on diagnosis, treatment and therapeutic angiogenesis for arteriosclerosis obliterans]
Nippon rinsho. Japanese journal of clinical medicine 2006;64(11):2045-51.
2006: Shiraya Suguru; Miwa Ken; Aoki Motokuni; Miyake Takashi; Oishi Masako; Kataoka Kazusaburo; Ohgi Shigetsugu; Ogihara Toshio; Kaneda Yasufumi; Morishita Ryuichi
Hypertension accelerated experimental abdominal aortic aneurysm through upregulation of nuclear factor kappaB and Ets.
Hypertension 2006;48(4):628-36.
2006: Saito Yukihiro; Nakagami Hironori; Morishita Ryuichi; Takami Yoichi; Kikuchi Yasushi; Hayashi Hiroki; Nishikawa Tomoyuki; Tamai Katsuto; Azuma Nobuyoshi; Sasajima Tadahiro; Kaneda Yasufumi
Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis.
Circulation 2006;114(11):1177-84.
2006: Miyake Takashi; Aoki Motokuni; Shiraya Suguru; Tanemoto Kazuo; Ogihara Toshio; Kaneda Yasufumi; Morishita Ryuichi
Inhibitory effects of NFkappaB decoy oligodeoxynucleotides on neointimal hyperplasia in a rabbit vein graft model.
Journal of molecular and cellular cardiology 2006;41(3):431-40.
2006: Tomita Tetsuya; Kunugiza Yasuo; Tomita Naruya; Takano Hiroshi; Morishita Ryuichi; Kaneda Yasufumi; Yoshikawa Hideki
E2F decoy oligodeoxynucleotide ameliorates cartilage invasion by infiltrating synovium derived from rheumatoid arthritis.
International journal of molecular medicine 2006;18(2):257-65.
2006: Azuma J; Taniyama Y; Takeya Y; Iekushi K; Aoki M; Dosaka N; Matsumoto K; Nakamura T; Ogihara T; Morishita R
Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy.
Gene therapy 2006;13(16):1206-13.
2006: Kunugiza Y; Tomita N; Taniyama Y; Tomita T; Osako M K; Tamai K; Tanabe T; Kaneda Y; Yoshikawa H; Morishita R
Acceleration of wound healing by combined gene transfer of hepatocyte growth factor and prostacyclin synthase with Shima Jet.
Gene therapy 2006;13(15):1143-52.
2006: Morishita Ryuichi
[Gene therapy for hypertension]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():565-70.
2006: Nakagami Hironori; Nakagawa Namika; Takeya Yasushi; Kashiwagi Katsunobu; Ishida Chisato; Hayashi Shin-ichiro; Aoki Motokuni; Matsumoto Kunio; Nakamura Toshikazu; Ogihara Toshio; Morishita Ryuichi
Model of vasculogenesis from embryonic stem cells for vascular research and regenerative medicine.
Hypertension 2006;48(1):112-9.
2006: Shimizu H; Nakagami H; Tsukamoto I; Morita S; Kunugiza Y; Tomita T; Yoshikawa H; Kaneda Y; Ogihara T; Morishita R
NFkappaB decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclasts.
Gene therapy 2006;13(12):933-41.
2006: Sato Naoyuki; Okochi Masayasu; Taniyama Yoshiaki; Kurinami Hitomi; Shimamura Munehisa; Takeuchi Daisuke; Hamada Hizuki; Fukumori Akio; Kiyosue Kazuyuki; Taguchi Takahisa; Tanaka Toshiyuki; Miyasaka Masayuki; Takeda Masatoshi; Ogihara Toshio; Morishita Ryuichi
Development of new screening system for Alzheimer disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils.
Neurobiology of disease 2006;22(3):487-95.
2006: Koibuchi Nobutaka; Taniyama Yoshiaki; Nagao Kaori; Ogihara Toshio; Kaneda Yasufumi; Morishita Ryuichi
The effect of VEGF on blood vessels and blood cells during Xenopus development.
Biochemical and biophysical research communications 2006;344(1):339-45.
2006: Nakagami Hironori; Morishita Ryuichi; Maeda Kazuhisa; Kikuchi Yasushi; Ogihara Toshio; Kaneda Yasufumi
Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy.
Journal of atherosclerosis and thrombosis 2006;13(2):77-81.
2006: Nakagami Hironori; Tomita Naruya; Kaneda Yasufumi; Ogihara Toshio; Morishita Ryuichi
Anti-oxidant gene therapy by NF kappa B decoy oligodeoxynucleotide.
Current pharmaceutical biotechnology 2006;7(2):95-100.
2006: Aoki Motokuni; Morishita Ryuichi
[Therapeutic angiogenesis for ischemic diseases]
Nippon rinsho. Japanese journal of clinical medicine 2006;64(4):762-8.
2006: Nishikawa Tomoyuki; Nakagami Hironori; Matsuki Atsushi; Maeda Akito; Yo Chiah Yian; Harada Taku; Morishita Ryuichi; Tamai Katsuto; Kaneda Yasufumi
Development of high-throughput functional screening of therapeutic genes, using a hemagglutinating virus of Japan envelope vector.
Human gene therapy 2006;17(4):470-5.
2006: Shimamura Munehisa; Sato Naoyuki; Waguri Satoshi; Uchiyama Yasuo; Hayashi Takuya; Iida Hidehiro; Nakamura Toshikazu; Ogihara Toshio; Kaneda Yasufumi; Morishita Ryuichi
Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction.
Hypertension 2006;47(4):742-51.
2006: Miyake T; Aoki M; Nakashima H; Kawasaki T; Oishi M; Kataoka K; Tanemoto K; Ogihara T; Kaneda Y; Morishita R
Prevention of abdominal aortic aneurysms by simultaneous inhibition of NFkappaB and ets using chimeric decoy oligonucleotides in a rabbit model.
Gene therapy 2006;13(8):695-704.
2006: Morishita Ryuichi; Tomita Naruya
[Effect of nifedipine on organ protection: potential application in patients with aortic aneurysm]
Drugs 2006;66 Spec No 1():31-3.
2006: Kunugiza Yasuo; Tomita Tetsuya; Tomita Naruya; Morishita Ryuichi; Yoshikawa Hideki
Inhibitory effect of ribbon-type NF-kappaB decoy oligodeoxynucleotides on osteoclast induction and activity in vitro and in vivo.
Arthritis research & therapy 2006;8(4):R103.
2006: Inagaki Hiroshi; Suzuki Jun-ichi; Ogawa Masahito; Taniyama Yoshiaki; Morishita Ryuichi; Isobe Mitsuaki
Ultrasound-microbubble-mediated NF-kappaB decoy transfection attenuates neointimal formation after arterial injury in mice.
Journal of vascular research 2006;43(1):12-8.
2006: Shimamura Munehisa; Sato Naoyuki; Yoshimura Shinichi; Kaneda Yasufumi; Morishita Ryuichi
HVJ-based non-viral gene transfer method: successful gene therapy using HGF and VEGF genes in experimental ischemia.
Frontiers in bioscience : a journal and virtual library 2006;11():753-9.
2005: Tamai Katsuto; Kaneda Yasufumi; Nakamura Hiroshige; Aoki Motohiro; Morishita Ryuichi; Hashimoto Koji; Morita Akimichi; Katayama Ichiro; Hanada Katsumi
[NFkappaB decoy DNA for treatment of atopic dermatitis]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():659-63.
2005: Taniyama Yoshiaki; Morishita Ryuichi; Makino Hiroshi; Azuma Junya; Ogihara Toshio
[Gene therapy in congestive heart failure]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():594-7.
2005: Taniyama Yoshiaki; Morishita Ryuichi; Azuma Junya; Iekushi Kazuma
[Therapeutic angiogenesis for ischemic heart disease induced by gene transfer]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():588-93.
2005: Makino Hirofumi; Ogihara Toshio; Morishita Ryuichi
[Gene therapy for peripheral arterial disease]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():582-7.
2005: Nkagami Hironori; Kaneda Yasufumi; Morishita Ryuichi
[Future view of gene therapy in cardiovascular field]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():577-81.
2005: Morishita Ryuichi
A scientific rationale for the CREST trial results: evidence for the mechanism of action of cilostazol in restenosis.
Atherosclerosis. Supplements 2005;6(4):41-6.
2005: Nakagami Hironori; Maeda Kazuhisa; Morishita Ryuichi; Iguchi Sota; Nishikawa Tomoyuki; Takami Yoichi; Kikuchi Yasushi; Saito Yukihiro; Tamai Katsuto; Ogihara Toshio; Kaneda Yasufumi
Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(12):2542-7.
2005: Shimamura Munehisa; Sato Naoyuki; Taniyama Yoshiaki; Kurinami Hitomi; Tanaka Hiroyuki; Takami Toshihiro; Ogihara Toshio; Tohyama Masaya; Kaneda Yasufumi; Morishita Ryuichi
Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubbles.
The journal of gene medicine 2005;7(11):1468-74.
2005: Sato Naoyuki; Shimamura Munehisa; Morishita Ryuichi
Recent progress in cerebrovascular gene therapy.
Current neurovascular research 2005;2(3):235-47.
2005: Makino Hirofumi; Aoki Motokuni; Hashiya Naotaka; Yamasaki Keita; Shimizu Hideo; Miwa Ken; Ogihara Toshio; Morishita Ryuichi
A calcium-channel blocker, benidipine, improves forearm reactive hyperemia in patients with essential hypertension.
Blood pressure. Supplement 2005;1():39-44.
2005: Miwa K; Nakashima H; Aoki M; Miyake T; Kawasaki T; Iwai M; Oishi M; Kataoka K; Ohgi S; Ogihara T; Kaneda Y; Morishita R
Inhibition of ets, an essential transcription factor for angiogenesis, to prevent the development of abdominal aortic aneurysm in a rat model.
Gene therapy 2005;12(14):1109-18.
2005: Taniyama Yoshiaki; Morishita Ryuichi; Azuma Junya; Iekushi Kazuma; Ogihara Toshio
[Gene therapy for diabetic microangiopathy]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 6():153-8.
2005: Nakagami Hironori; Kaneda Yasufumi; Ogihara Toshio; Morishita Ryuichi
Hepatocyte growth factor as potential cardiovascular therapy.
Expert review of cardiovascular therapy 2005;3(3):513-9.
2005: Morishita Ryuichi; Aoki Motokuni; Ogihara Toshio
Does gene therapy become pharmacotherapy?
Experimental physiology 2005;90(3):307-13.
2005: Makino Hirofumi; Ogihara Toshio; Morishita Ryuichi
[Gene therapy for peripheral arterial diseases]
Nippon rinsho. Japanese journal of clinical medicine 2005;63(3):491-7.
2005: Hashiya Naotaka; Ogihara Toshio; Morishita Ryuichi
[Practice of gene therapy]
Nippon rinsho. Japanese journal of clinical medicine 2005;63(3):370-2.
2005: Nakagami Hironori; Kaneda Yasufumi; Ogihara Toshio; Morishita Ryuichi
Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis.
Current diabetes reviews 2005;1(1):59-63.
2005: Koike Hiromi; Tomita Naruya; Azuma Haruhito; Taniyama Yoshiaki; Yamasaki Keita; Kunugiza Yasuo; Tachibana Katsuro; Ogihara Toshio; Morishita Ryuichi
An efficient gene transfer method mediated by ultrasound and microbubbles into the kidney.
The journal of gene medicine 2005;7(1):108-16.
2005: Makino Hirofumi; Aoki Motokuni; Hashiya Naotaka; Yamasaki Keita; Shimizu Hideo; Miwa Ken; Ogihara Toshio; Morishita Ryuichi
A calcium-channel blocker, benidipine, improves forearm reactive hyperemia in patients with essential hypertension.
Blood pressure 2005;14 Suppl 1():39-44.
2004: Tomita Naruya; Azuma Haruhito; Kaneda Yasufumi; Ogihara Toshio; Morishita Ryuichi
Application of decoy oligodeoxynucleotides-based approach to renal diseases.
Current drug targets 2004;5(8):717-33.
2004: Hiraoka Kazuya; Yamamoto Seiji; Otsuru Satoru; Nakai Seiji; Tamai Katsuto; Morishita Ryuichi; Ogihara Toshio; Kaneda Yasufumi
Enhanced tumor-specific long-term immunity of hemagglutinating [correction of hemaggluttinating] virus of Japan-mediated dendritic cell-tumor fused cell vaccination by coadministration with CpG oligodeoxynucleotides.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4297-307.
2004: Yamamoto Kei; Tomita Naruya; Yoshimura Shin-ichi; Nakagami Hironori; Taniyama Yoshiaki; Yamasaki Keita; Ogihara Toshio; Morishita Ryuichi
Hypoxia-induced renal epithelial cell death through caspase-dependent pathway: role of Bcl-2, Bcl-xL and Bax in tubular injury.
International journal of molecular medicine 2004;14(4):633-40.
2004: Shimamura M; Sato N; Taniyama Y; Yamamoto S; Endoh M; Kurinami H; Aoki M; Ogihara T; Kaneda Y; Morishita R
Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound.
Gene therapy 2004;11(20):1532-9.
2004: Yamasaki K; Aoki M; Makino H; Hashiya N; Shimizu H; Ohishi M; Ogihara T; Morishita R
Effect of nifedipine on endothelial function in normotensive smokers: potential contribution of increase in circulating hepatocyte growth factor.
Journal of human hypertension 2004;18(10):701-5.
2004: Morishita Ryuichi; Aoki Motokuni; Hashiya Naotaka; Makino Hirofumi; Yamasaki Keita; Azuma Junya; Sawa Yoshiki; Matsuda Hikaru; Kaneda Yasufumi; Ogihara Toshio
Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease.
Hypertension 2004;44(2):203-9.
2004: Morishita Ryuichi; Aoki Motokuni; Hashiya Naotaka; Yamasaki Keita; Kurinami Hitomi; Shimizu Shiro; Makino Hirofumi; Takesya Yasushi; Azuma Junya; Ogihara Toshio
Therapeutic angiogenesis using hepatocyte growth factor (HGF).
Current gene therapy 2004;4(2):199-206.
2004: Hashiya Naotaka; Jo Nobuo; Aoki Motokuni; Matsumoto Kunio; Nakamura Toshikazu; Sato Yasufumi; Ogata Nahoko; Ogihara Toshio; Kaneda Yasufumi; Morishita Ryuichi
In vivo evidence of angiogenesis induced by transcription factor Ets-1: Ets-1 is located upstream of angiogenesis cascade.
Circulation 2004;109(24):3035-41.
2004: Nakagami Hironori; Morishita Ryuichi; Nishikawa Tomoyuki; Shimizu Hideo; Iguchi Sota; Matsumoto Kunio; Nakamura Toshikazu; Kaneda Yasufumi; Ogihara Toshio
Lack of association between the hepatocyte growth factor receptor, c-met, and the anti-apoptotic action of bag-1 in endothelial cells.
Hypertension research : official journal of the Japanese Society of Hypertension 2004;27(5):359-65.
2004: Morishita Ryuichi
Perspective in progress of cardiovascular gene therapy.
Journal of pharmacological sciences 2004;95(1):1-8.
2004: Tomita Naruya; Kim John Y S; Gibbons Gary H; Zhang Lunan; Kaneda Yasufumi; Stahl Rolf A K; Ogborn Malcom; Venderville Benoit; Morishita Ryuichi; Baran Dana; Dzau Victro J
Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis.
International journal of molecular medicine 2004;13(5):629-36.
2004: Koibuchi Nobutaka; Kaneda Yasufumi; Taniyama Yoshiaki; Matsumoto Kunio; Nakamura Toshikazu; Ogihara Toshio; Morishita Ryuichi
Essential role of HGF (hepatocyte growth factor) in blood formation in Xenopus.
Blood 2004;103(9):3320-5.
2004: Hashiya Naotaka; Aoki Motokuni; Tachibana Katsuro; Taniyama Yoshiaki; Yamasaki Keita; Hiraoka Kazuya; Makino Hirofumi; Yasufumi Kaneda; Ogihara Toshio; Morishita Ryuichi
Local delivery of E2F decoy oligodeoxynucleotides using ultrasound with microbubble agent (Optison) inhibits intimal hyperplasia after balloon injury in rat carotid artery model.
Biochemical and biophysical research communications 2004;317(2):508-14.
2004: Morishita Ryuichi; Tomita Naruya; Kaneda Yasufumi; Ogihara Toshio
Molecular therapy to inhibit NFkappaB activation by transcription factor decoy oligonucleotides.
Current opinion in pharmacology 2004;4(2):139-46.
2004: Matsuki Atsushi; Yamamoto Seiji; Nakagami Hironori; Aoki Motokuni; Tamai Katsuto; Matsumoto Kunio; Nakamura Toshikazu; Ogihara Toshio; Kaneda Yasufumi; Morishita Ryuichi
No influence of tumor growth by intramuscular injection of hepatocyte growth factor plasmid DNA: safety evaluation of therapeutic angiogenesis gene therapy in mice.
Biochemical and biophysical research communications 2004;315(1):59-65.
2004: Makino Hirofumi; Aoki Motokuni; Hashiya Naotaka; Yamasaki Keita; Hiraoka Kazuya; Shimizu Hideo; Azuma Junya; Kurinami Hitomi; Ogihara Toshio; Morishita Ryuichi
Increase in peripheral blood flow by intravenous administration of prostaglandin E1 in patients with peripheral arterial disease, accompanied by up-regulation of hepatocyte growth factor.
Hypertension research : official journal of the Japanese Society of Hypertension 2004;27(2):85-91.
2004: Taniyama Yoshiaki; Tomita Naruya; Endoh Seiji; Kaneda Yasufumi; Ogihara Toshio; Morishita Ryuichi
[Gene transfer with ultrasound and microbubbles (optison) as a potential treatment for cardiovascular diseases]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 2004;41(1):51-4.
2004: Shimamura Munehisa; Sato Naoyuki; Oshima Kazuo; Aoki Motokuni; Kurinami Hitomi; Waguri Satoshi; Uchiyama Yasuo; Ogihara Toshio; Kaneda Yasufumi; Morishita Ryuichi
Novel therapeutic strategy to treat brain ischemia: overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model.
Circulation 2004;109(3):424-31.
2004: Nakashima Hideki; Aoki Motokuni; Miyake Takashi; Kawasaki Tomio; Iwai Masahiro; Jo Nobuo; Oishi Masako; Kataoka Kazusaburo; Ohgi Shigetsugu; Ogihara Toshio; Kaneda Yasufumi; Morishita Ryuichi
Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors.
Circulation 2004;109(1):132-8.
2004: Oshima Kazuo; Shimamura Munehisa; Mizuno Shinya; Tamai Katsuto; Doi Katsumi; Morishita Ryuichi; Nakamura Toshikazu; Kubo Takeshi; Kaneda Yasufumi
Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):212-4.
2003: Aoki Motokuni; Morishita Ryuichi; Ogihara Toshio
Oligonucleotide-based molecular therapy for restenosis after angioplasty.
Current drug targets 2003;4(8):613-8.
2003: Tomita Naruya; Ogihara Toshio; Morishita Ryuichi
Transcription factors as molecular targets: molecular mechanisms of decoy ODN and their design.
Current drug targets 2003;4(8):603-8.
2003: Morishita Ryuichi
Transcription factor as molecular targets: is transcription factor decoy a novel drug?
Current drug targets 2003;4(8):2 p before 599.
2003: Namba Tsunetatsu; Koike Hiromi; Murakami Kazushi; Aoki Motokuni; Makino Hirofumi; Hashiya Naotaka; Ogihara Toshio; Kaneda Yasufumi; Kohno Masakazu; Morishita Ryuichi
Angiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model.
Circulation 2003;108(18):2250-7.
2003: Hiraoka Kazuya; Koike Hiromi; Yamamoto Seiji; Tomita Naruya; Yokoyama Chieko; Tanabe Tadashi; Aikou Takashi; Ogihara Toshio; Kaneda Yasufumi; Morishita Ryuichi
Enhanced therapeutic angiogenesis by cotransfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA.
Circulation 2003;108(21):2689-96.
2003: Tomita Naruya; Ogihara Toshio; Morishita Ryuichi
Therapeutic potential of decoy oligonucleotides strategy in cardiovascular diseases.
Expert review of cardiovascular therapy 2003;1(3):463-70.
2003: Hayashi Shin-ichiro; Azuma Junya; Ogihara Toshio; Morishita Ryuichi
[Gene therapy for myocardial regeneration]
Nippon rinsho. Japanese journal of clinical medicine 2003;61(5):867-70.
2003: Tomita Naruya; Azuma Haruhito; Kaneda Yasufumi; Ogihara Toshio; Morishita Ryuichi
Gene therapy with transcription factor decoy oligonucleotides as a potential treatment for cardiovascular diseases.
Current drug targets 2003;4(4):339-46.
2003: Tomita Naruya; Tomita Tetsuya; Yuyama Kazuhiko; Tougan Takahiro; Tajima Tsuyoshi; Ogihara Toshio; Morishita Ryuichi
Development of novel decoy oligonucleotides: advantages of circular dumb-bell decoy.
Current opinion in molecular therapeutics 2003;5(2):107-12.
2003: Makino Hirofumi; Ogihara Toshio; Morishita Ryuichi
[Therapeutic angiogenesis by angiogenic growth factor]
Nippon rinsho. Japanese journal of clinical medicine 2003;61 Suppl 4():692-7.
2003: Aoki Motokuni; Ogihara Toshio; Morishita Ryuichi
[Gene therapy for restenosis after angioplasty]
Nippon rinsho. Japanese journal of clinical medicine 2003;61 Suppl 4():685-91.
2003: Koike Hiromi; Morishita Ryuichi; Iguchi Sohta; Aoki Motokuni; Matsumoto Kunio; Nakamura Toshikazu; Yokoyama Chieko; Tanabe Tadashi; Ogihara Toshio; Kaneda Yasufumi
Enhanced angiogenesis and improvement of neuropathy by cotransfection of human hepatocyte growth factor and prostacyclin synthase gene.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):779-81.
2003: Morishita Ryuichi
Cardiovascular disease and angiogenesis.
Internal medicine (Tokyo, Japan) 2003;42(3):301-2.
2003: Matsumoto Keiko; Morishita Ryuichi; Tomita N; Moriguchi Atsushi; Komai Norio; Aoki Motokuni; Matsumoto Kunio; Nakamura Toshikazu; Higaki Jitsuo; Ogihara Toshio
Improvement of endothelial dysfunction by angiotensin II blockade accompanied by induction of vascular hepatocyte growth factor system in diabetic spontaneously hypertensive rats.
Heart and vessels 2003;18(1):18-25.
2003: Tomita Naruya; Morishita Ryuichi; Taniyama Yoshiaki; Koike Hiromi; Aoki Motokuni; Shimizu Hideo; Matsumoto Kunio; Nakamura Toshikazu; Kaneda Yasufumi; Ogihara Toshio
Angiogenic property of hepatocyte growth factor is dependent on upregulation of essential transcription factor for angiogenesis, ets-1.
Circulation 2003;107(10):1411-7.
2003: Yamamoto Seiji; Yamano Tomoki; Tanaka Maki; Hoon Dave S B; Takao Sonshin; Morishita Ryuichi; Aikou Takashi; Kaneda Yasufumi
A novel combination of suicide gene therapy and histone deacetylase inhibitor for treatment of malignant melanoma.
Cancer gene therapy 2003;10(3):179-86.
2003: Yamasaki K; Asai T; Shimizu M; Aoki M; Hashiya N; Sakonjo H; Makino H; Kaneda Y; Ogihara T; Morishita R
Inhibition of NFkappaB activation using cis-element 'decoy' of NFkappaB binding site reduces neointimal formation in porcine balloon-injured coronary artery model.
Gene therapy 2003;10(4):356-64.
2003: Nakabayashi M; Morishita R; Nakagami H; Kuba K; Matsumoto K; Nakamura T; Tano Y; Kaneda Y
HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model.
Diabetologia 2003;46(1):115-23.
2003: Shimamura Munehisa; Morishita Ryuichi; Endoh Masayuki; Oshima Kazuo; Aoki Motokuni; Waguri Satoshi; Uchiyama Yasuo; Kaneda Yasufumi
HVJ-envelope vector for gene transfer into central nervous system.
Biochemical and biophysical research communications 2003;300(2):464-71.
2003: Morishita Ryuichi; Kaneda Yasufumi; Ogihara Toshio
Therapeutic potential of oligonucleotide-based therapy in cardiovascular disease.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2003;17(6):383-9.
2002: Morishita Ryuichi
Recent progress in gene therapy for cardiovascular disease.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(12):1077-86.
2002: Morishita R; Gibbons G H; Kaneda Y; Zhang L; Ogihara T; Dzau V J
Apolipoprotein E-deficient mice created by systemic administration of antisense oligodeoxynucleotides: a new model for lipoprotein metabolism studies.
The Journal of endocrinology 2002;175(2):475-85.
2002: Makino Hirofumi; Ogihara Toshio; Morishita Ryuichi
[Gene therapy for peripheral arterial diseases in diabetes mellitus]
Nippon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 10():449-56.
2002: Morishita Ryuichi
[Gene therapy in cardiovascular medicine as new pharmacological therapy]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2002;120(4):222-8.
2002: Matsumoto K; Morishita R; Tomita N; Moriguchi A; Yamasaki K; Aoki M; Matsumoto K; Nakamura T; Higaki J; Ogihara T
Impaired endothelial dysfunction in diabetes mellitus rats was restored by oral administration of prostaglandin I2 analogue.
The Journal of endocrinology 2002;175(1):217-23.
2002: Morishita Ryuichi; Tomita Naruya; Ogihara Toshio
HMG-Co A reductase inhibitors in the treatment of cardiovascular diseases: stabilization of coronary artery plaque.
Current drug targets 2002;3(5):379-85.
2002: Aoki Motokuni; Ogihara Toshio; Morishita Ryuichi
[The latest review of therapeutic angiogenesis using angiogenic growth factors to peripheral arterial diseases]
Nippon rinsho. Japanese journal of clinical medicine 2002;60(9):1845-55.
2002: Tomita Naruya; Morishita Ryuichi; Yamamoto Kei; Higaki Jitsuo; Dzau Victor J; Ogihara Toshio; Kaneda Yasufumi
Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomes.
The journal of gene medicine 2002;4(5):527-35.
2002: Nakamura H; Aoki M; Tamai K; Oishi M; Ogihara T; Kaneda Y; Morishita R
Prevention and regression of atopic dermatitis by ointment containing NF-kB decoy oligodeoxynucleotides in NC/Nga atopic mouse model.
Gene therapy 2002;9(18):1221-9.
2002: Komai Norio; Morishita Ryuichi; Yamada Shingo; Oishi Mitsuru; Iguchi Sota; Aoki Motokuni; Sasaki Minako; Sakurabayashi Ikunosuke; Higaki Jitsuo; Ogihara Toshio
Mitogenic activity of oxidized lipoprotein (a) on human vascular smooth muscle cells.
Hypertension 2002;40(3):310-4.
2002: Kaneda Yasufumi; Nakajima Toshihiro; Nishikawa Tomoyuki; Yamamoto Seiji; Ikegami Hiroyuki; Suzuki Naho; Nakamura Hitomi; Morishita Ryuichi; Kotani Hitoshi
Hemagglutinating virus of Japan (HVJ) envelope vector as a versatile gene delivery system.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(2):219-26.
2002: Nakagami Hironori; Morishita Ryuichi; Yamamoto Kei; Taniyama Yoshiaki; Aoki Motokuni; Yamasaki Keita; Matsumoto Kunio; Nakamura Toshikazu; Kaneda Yasufumi; Ogihara Toshio
Hepatocyte growth factor prevents endothelial cell death through inhibition of bax translocation from cytosol to mitochondrial membrane.
Diabetes 2002;51(8):2604-11.
2002: Tomita Naruya; Morishita Ryuichi; Koike Hiromi; Hashizume Masahide; Notake Mitsue; Fujitani Buichi; Kaneda Yasufumi; Horiuchi Masatsugu; Ogihara Toshio
Therapeutic approach to familial hypercholesterolemia by HVJ-liposomes in LDL receptor knockout mouse.
International journal of molecular medicine 2002;10(2):137-43.
2002: Taniyama Yoshiaki; Morishita Ryuichi; Aoki Motokuni; Hiraoka Kazuya; Yamasaki Keita; Hashiya Naotaka; Matsumoto Kunio; Nakamura Toshikazu; Kaneda Yasufumi; Ogihara Toshio
Angiogenesis and antifibrotic action by hepatocyte growth factor in cardiomyopathy.
Hypertension 2002;40(1):47-53.
2002: Morishita Ryuichi; Aoki Motokuni; Yo Yoshikage; Ogihara Toshio
Hepatocyte growth factor as cardiovascular hormone: role of HGF in the pathogenesis of cardiovascular disease.
Endocrine journal 2002;49(3):273-84.
2002: Komai Norio; Ohishi Mitsuru; Morishita Ryuichi; Moriguchi Atsushi; Kaibe Masaharu; Matsumoto Keiko; Rakugi Hiromi; Higaki Jitsuo; Ogihara Toshio
Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients.
American journal of hypertension 2002;15(6):499-506.
2002: Tomita Naruya; Morishita Ryuichi; Ogihara Toshio
[Pharmacological effects of HMG-CoA reductase inhibitors]
Nippon rinsho. Japanese journal of clinical medicine 2002;60(5):955-61.
2002: Mori Masaki; Nakagami Hironori; Morishita Ryuichi; Mitsuda Noriaki; Yamamoto Kei; Yoshimura Shin-ichi; Ohkubo Nobutaka; Sato Naoyuki; Ogihara Toshio; Kaneda Yasufumi
N141I mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression.
Life sciences 2002;70(21):2567-80.
2002: Tomita Naruya; Morishita Ryuichi; Tomita Tetsuya; Ogihara Toshio
Potential therapeutic applications of decoy oligonucleotides.
Current opinion in molecular therapeutics 2002;4(2):166-70.
2002: Nakamura T; Morishita R; Asai T; Tsuboniwa N; Aoki M; Sakonjo H; Yamasaki K; Hashiya N; Kaneda Y; Ogihara T
Molecular strategy using cis-element 'decoy' of E2F binding site inhibits neointimal formation in porcine balloon-injured coronary artery model.
Gene therapy 2002;9(8):488-94.
2002: Taniyama Y; Tachibana K; Hiraoka K; Aoki M; Yamamoto S; Matsumoto K; Nakamura T; Ogihara T; Kaneda Y; Morishita R
Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle.
Gene therapy 2002;9(6):372-80.
2002: Morishita Ryuichi; Sakaki Minako; Yamamoto Kei; Iguchi Sota; Aoki Motokuni; Yamasaki Keita; Matsumoto Kunio; Nakamura Toshikazu; Lawn Richard; Ogihara Toshio; Kaneda Yasufumi
Impairment of collateral formation in lipoprotein(a) transgenic mice: therapeutic angiogenesis induced by human hepatocyte growth factor gene.
Circulation 2002;105(12):1491-6.
2002: Taniyama Yoshiaki; Tachibana Katsuro; Hiraoka Kazuya; Namba Tsunetatsu; Yamasaki Keita; Hashiya Naotaka; Aoki Motokuni; Ogihara Toshio; Yasufumi Kaneda; Morishita Ryuichi
Local delivery of plasmid DNA into rat carotid artery using ultrasound.
Circulation 2002;105(10):1233-9.
2002: Nakamura Hiroshige; Morishita Ryuichi; Kaneda Yasufumi
Molecular therapy via transcriptional regulation with double-stranded oligodeoxynucleotides as decoys.
In vivo (Athens, Greece) 2002;16(1):45-8.
2002: Morishita Ryuichi; Kaneda Yasufumi
HVJ (hemagglutinating virus of Japan; Sendai virus)-liposome method.
Methods in enzymology 2002;346():619-27.
2001: Morishita R; Aoki M; Kaneda Y
Decoy oligodeoxynucleotides as novel cardiovascular drugs for cardiovascular disease.
Annals of the New York Academy of Sciences 2001;947():294-301; discussion 301-2.
2001: Aoki M; Ogihara T; Morishita R
[HGF as a key molecule in cardiovascular diseases]
Nippon rinsho. Japanese journal of clinical medicine 2001;59(12):2460-9.
2001: Miyata T; Yamamoto S; Sakamoto K; Morishita R; Kaneda Y
Novel immunotherapy for peritoneal dissemination of murine colon cancer with macrophage inflammatory protein-1beta mediated by a tumor-specific vector, HVJ cationic liposomes.
Cancer gene therapy 2001;8(11):852-60.
2001: Taniyama Y; Morishita R; Hiraoka K; Aoki M; Nakagami H; Yamasaki K; Matsumoto K; Nakamura T; Kaneda Y; Ogihara T
Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model: molecular mechanisms of delayed angiogenesis in diabetes.
Circulation 2001;104(19):2344-50.
2001: Morishita R; Aoki M; Kaneda Y; Ogihara T
Gene therapy in vascular medicine: recent advances and future perspectives.
Pharmacology & therapeutics 2001;91(2):105-14.
2001: Aoki M; Morishita R; Hayashi S; Jo N; Matsumoto K; Nakamura T; Kaneda Y; Ogihara T
Inhibition of neointimal formation after balloon injury by cilostazol, accompanied by improvement of endothelial dysfunction and induction of hepatocyte growth factor in rat diabetes model.
Diabetologia 2001;44(8):1034-42.
2001: Otomo T; Yamamoto S; Morishita R; Kaneda Y
EBV replicon vector system enhances transgene expression in vivo: applications to cancer gene therapy.
The journal of gene medicine 2001;3(4):345-52.
2001: Aoki M; Nata T; Morishita R; Matsushita H; Nakagami H; Yamamoto K; Yamazaki K; Nakabayashi M; Ogihara T; Kaneda Y
Endothelial apoptosis induced by oxidative stress through activation of NF-kappaB: antiapoptotic effect of antioxidant agents on endothelial cells.
Hypertension 2001;38(1):48-55.
2001: Nakagami H; Morishita R; Yamamoto K; Yoshimura S I; Taniyama Y; Aoki M; Matsubara H; Kim S; Kaneda Y; Ogihara T
Phosphorylation of p38 mitogen-activated protein kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells.
Diabetes 2001;50(6):1472-81.
2001: Yamamoto K; Morishita R; Hayashi S; Matsushita H; Nakagami H; Moriguchi A; Matsumoto K; Nakamura T; Kaneda Y; Ogihara T
Contribution of Bcl-2, but not Bcl-xL and Bax, to antiapoptotic actions of hepatocyte growth factor in hypoxia-conditioned human endothelial cells.
Hypertension 2001;37(5):1341-8.
2001: Tomita N; Morishita R; Ogihara T
[Ongoing clinical trials by vascular statin, cerivastatin]
Nippon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 3():477-82.
2001: Tsuboniwa N; Morishita R; Hirano T; Fujimoto J; Furukawa S; Kikumori M; Okuyama A; Kaneda Y
Safety evaluation of hemagglutinating virus of Japan--artificial viral envelope liposomes in nonhuman primates.
Human gene therapy 2001;12(5):469-87.
2001: Taniyama Y; Morishita R; Aoki M; Nakagami H; Yamamoto K; Yamazaki K; Matsumoto K; Nakamura T; Kaneda Y; Ogihara T
Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease.
Gene therapy 2001;8(3):181-9.
2001: Higaki J; Katsuya T; Morishita R; Ogihara T
Symposium on the etiology of hypertension--summarizing studies in 20th century. 1. Hypertension and genes.
Internal medicine (Tokyo, Japan) 2001;40(2):144-7.
2001: Nakagami H; Morishita R; Yamamoto K; Taniyama Y; Aoki M; Matsumoto K; Nakamura T; Kaneda Y; Horiuchi M; Ogihara T
Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells.
Hypertension 2001;37(2 Part 2):581-6.
2001: Matsumoto K; Morishita R; Moriguchi A; Tomita N; Aoki M; Sakonjo H; Matsumoto K; Nakamura T; Higaki J; Ogihara T
Inhibition of neointima by angiotensin-converting enzyme inhibitor in porcine coronary artery balloon-injury model.
Hypertension 2001;37(2):270-4.
2001: Aoki M; Morishita R; Ogihara T
[Gene therapy for arteriosclerotic diseases]
Nippon rinsho. Japanese journal of clinical medicine 2001;59(1):43-52.
2001: Tomita N; Morishita R; Tomita S; Kaneda Y; Higaki J; Ogihara T; Horiuchi M
Inhibition of TNF-alpha, induced cytokine and adhesion molecule. Expression in glomerular cells in vitro and in vivo by transcription factor decoy for NFkappaB.
Experimental nephrology 2001;9(3):181-90.
2000: Kawauchi M; Suzuki J; Morishita R; Wada Y; Izawa A; Tomita N; Amano J; Kaneda Y; Ogihara T; Takamoto S; Isobe M
Gene therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and nonhuman primates.
Circulation research 2000;87(11):1063-8.
2000: Hayashi K; Nakamura S; Morishita R; Moriguchi A; Aoki M; Matsumoto K; Nakamura T; Kaneda Y; Sakai N; Ogihara T
In vivo transfer of human hepatocyte growth factor gene accelerates re-endothelialization and inhibits neointimal formation after balloon injury in rat model.
Gene therapy 2000;7(19):1664-71.
2000: Nakagami H; Morishita R; Yamamoto K; Taniyama Y; Aoki M; Kim S; Matsumoto K; Nakamura T; Higaki J; Ogihara T
Anti-apoptotic action of hepatocyte growth factor through mitogen-activated protein kinase on human aortic endothelial cells.
Journal of hypertension 2000;18(10):1411-20.
2000: Nagaya N; Yokoyama C; Kyotani S; Shimonishi M; Morishita R; Uematsu M; Nishikimi T; Nakanishi N; Ogihara T; Yamagishi M; Miyatake K; Kaneda Y; Tanabe T
Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats.
Circulation 2000;102(16):2005-10.
2000: Yamamoto K; Morishita R; Tomita N; Shimozato T; Nakagami H; Kikuchi A; Aoki M; Higaki J; Kaneda Y; Ogihara T
Ribozyme oligonucleotides against transforming growth factor-beta inhibited neointimal formation after vascular injury in rat model: potential application of ribozyme strategy to treat cardiovascular disease.
Circulation 2000;102(11):1308-14.
2000: Tomita N; Morishita R; Tomita S; Gibbons G H; Zhang L; Horiuchi M; Kaneda Y; Higaki J; Ogihara T; Dzau V J
Transcription factor decoy for NFkappaB inhibits TNF-alpha-induced cytokine and adhesion molecule expression in vivo.
Gene therapy 2000;7(15):1326-32.
2000: Morishita R; Aoki M; Kaneda Y
Oligonucleotide-based gene therapy for cardiovascular disease: are oligonucleotide therapeutics novel cardiovascular drugs?
Current drug targets 2000;1(1):15-23.
2000: Taniyama Y; Morishita R; Nakagami H; Moriguchi A; Sakonjo H; Shokei-Kim; Matsumoto K; Nakamura T; Higaki J; Ogihara T
Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamsters.
Circulation 2000;102(2):246-52.
2000: Morishita R; Gibbons G H; Kaneda Y; Ogihara T; Dzau V J
Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose level in diabetic mouse: A model of gene therapy.
Biochemical and biophysical research communications 2000;273(2):666-74.
2000: Tomita N; Morishita R; Lan H Y; Yamamoto K; Hashizume M; Notake M; Toyosawa K; Fujitani B; Mu W; Nikolic-Paterson D J; Atkins R C; Kaneda Y; Higaki J; Ogihara T
In vivo administration of a nuclear transcription factor-kappaB decoy suppresses experimental crescentic glomerulonephritis.
Journal of the American Society of Nephrology : JASN 2000;11(7):1244-52.
2000: Yamano T; Ura K; Morishita R; Nakajima H; Monden M; Kaneda Y
Amplification of transgene expression in vitro and in vivo using a novel inhibitor of histone deacetylase.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(6):574-80.
2000: Morishita R; Aoki M; Nakamura S; Higaki J; Kaneda Y; Ogihara T
Gene therapy for cardiovascular disease using hepatocyte growth factor.
Annals of the New York Academy of Sciences 2000;902():369-76.
2000: Isobe M; Suzuki J; Morishita R; Kaneda Y; Amano J
Gene therapy for heart transplantation-associated coronary arteriosclerosis.
Annals of the New York Academy of Sciences 2000;902():77-83.
2000: Matsushita H; Morishita R; Nata T; Aoki M; Nakagami H; Taniyama Y; Yamamoto K; Higaki J; Yasufumi K; Ogihara T
Hypoxia-induced endothelial apoptosis through nuclear factor-kappaB (NF-kappaB)-mediated bcl-2 suppression: in vivo evidence of the importance of NF-kappaB in endothelial cell regulation.
Circulation research 2000;86(9):974-81.
2000: Morishita R; Gibbons G H; Tomita N; Zhang L; Kaneda Y; Ogihara T; Dzau V J
Antisense oligodeoxynucleotide inhibition of vascular angiotensin-converting enzyme expression attenuates neointimal formation: evidence for tissue angiotensin-converting enzyme function.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(4):915-22.
2000: Morishita R
[Oligonucleotide-based therapy as a potential new pharmacotherapy]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2000;115(3):123-30.
2000: Morishita R; Aoki M; Ogihara T
Functional analysis of cardiovascular renin-angiotensin system using a gain or loss of function approach.
Hypertension research : official journal of the Japanese Society of Hypertension 2000;23(2):137-41.
2000: Matsushita H; Morishita R; Aoki M; Tomita N; Taniyama Y; Nakagami H; Shimozato T; Higaki J; Kaneda Y; Ogihara T
Transfection of antisense p53 tumor suppressor gene oligodeoxynucleotides into rat carotid artery results in abnormal growth of vascular smooth muscle cells.
Circulation 2000;101(12):1447-52.
2000: Aoki M; Morishita R; Taniyama Y; Kida I; Moriguchi A; Matsumoto K; Nakamura T; Kaneda Y; Higaki J; Ogihara T
Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: up-regulation of essential transcription factor for angiogenesis, ets.
Gene therapy 2000;7(5):417-27.
2000: Kaneda Y; Saeki Y; Nakabayashi M; Zhou W Z; Kaneda M W; Morishita R
Enhancement of transgene expression by cotransfection of oriP plasmid with EBNA-1 expression vector.
Human gene therapy 2000;11(3):471-9.
2000: Higaki J; Aoki M; Morishita R; Kida I; Taniyama Y; Tomita N; Yamamoto K; Moriguchi A; Kaneda Y; Ogihara T
In vivo evidence of the importance of cardiac angiotensin-converting enzyme in the pathogenesis of cardiac hypertrophy.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(2):428-34.
2000: Hayashi S; Morishita R; Matsushita H; Nakagami H; Taniyama Y; Nakamura T; Aoki M; Yamamoto K; Higaki J; Ogihara T
Cyclic AMP inhibited proliferation of human aortic vascular smooth muscle cells, accompanied by induction of p53 and p21.
Hypertension 2000;35(1 Pt 2):237-43.
2000: Aoki M; Morishita R; Taniyama Y; Kaneda Y; Ogihara T
Therapeutic angiogenesis induced by hepatocyte growth factor: potential gene therapy for ischemic diseases.
Journal of atherosclerosis and thrombosis 2000;7(2):71-6.
2000: Tomita N; Morishita R; Higaki J; Ogihara T
Novel molecular therapeutic approach to cardiovascular disease based on hepatocyte growth factor.
Journal of atherosclerosis and thrombosis 2000;7(1):1-7.
1999: Tomita T; Takeuchi E; Tomita N; Morishita R; Kaneko M; Yamamoto K; Nakase T; Seki H; Kato K; Kaneda Y; Ochi T
Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy.
Arthritis and rheumatism 1999;42(12):2532-42.
1999: Hayashi S; Morishita R; Nakamura S; Yamamoto K; Moriguchi A; Nagano T; Taiji M; Noguchi H; Matsumoto K; Nakamura T; Higaki J; Ogihara T
Potential role of hepatocyte growth factor, a novel angiogenic growth factor, in peripheral arterial disease: downregulation of HGF in response to hypoxia in vascular cells.
Circulation 1999;100(19 Suppl):II301-8.
1999: Zhou W Z; Hoon D S; Huang S K; Fujii S; Hashimoto K; Morishita R; Kaneda Y
RNA melanoma vaccine: induction of antitumor immunity by human glycoprotein 100 mRNA immunization.
Human gene therapy 1999;10(16):2719-24.
1999: Zhou W Z; Kaneda Y; Huang S; Morishita R; Hoon D
Protective immunization against melanoma by gp100 DNA-HVJ-liposome vaccine.
Gene therapy 1999;6(10):1768-73.
1999: Kaneda Y; Morishita R
[Gene therapy of cardiovascular disorders]
Human cell : official journal of Human Cell Research Society 1999;12(3):109-14.
1999: Morishita R; Moriguchi A; Higaki J; Ogihara T
Hepatocyte growth factor (HGF) as a potential index of severity of hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 1999;22(3):161-7.
1999: Nakamura S; Moriguchi A; Morishita R; Yamada K; Nishii T; Tomita N; Ohishi M; Kaneda Y; Higaki J; Ogihara T
Activation of the brain angiotensin system by in vivo human angiotensin-converting enzyme gene transfer in rats.
Hypertension 1999;34(2):302-8.
1999: Matsumoto K; Morishita R; Moriguchi A; Tomita N; Yo Y; Nishii T; Nakamura T; Higaki J; Ogihara T
Prevention of renal damage by angiotensin II blockade, accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats.
Hypertension 1999;34(2):279-84.
1999: Aoki M; Morishita R; Matsushita H; Hayashi S; Nakagami H; Yamamoto K; Moriguchi A; Kaneda Y; Higaki J; Ogihara T
Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells. Potential role of p53 in regulation of vascular smooth muscle cell growth.
Hypertension 1999;34(2):192-200.
1999: Nishii T; Moriguchi A; Morishita R; Yamada K; Nakamura S; Tomita N; Kaneda Y; Fukamizu A; Mikami H; Higaki J; Ogihara T
Angiotensinogen gene-activating elements regulate blood pressure in the brain.
Circulation research 1999;85(3):257-63.
1999: Kida I; Morishita R; Ogihara T
[A new medical treatment for thrombosis by genetic engineering]
Nippon rinsho. Japanese journal of clinical medicine 1999;57(7):1519-25.
1999: Kaneda Y; Saeki Y; Morishita R
Gene therapy using HVJ-liposomes: the best of both worlds?
Molecular medicine today 1999;5(7):298-303.
1999: Morishita R; Nakamura S; Hayashi S; Taniyama Y; Moriguchi A; Nagano T; Taiji M; Noguchi H; Takeshita S; Matsumoto K; Nakamura T; Higaki J; Ogihara T
Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy.
Hypertension 1999;33(6):1379-84.
1999: Todaka T; Yokoyama C; Yanamoto H; Hashimoto N; Nagata I; Tsukahara T; Hara S; Hatae T; Morishita R; Aoki M; Ogihara T; Kaneda Y; Tanabe T
Gene transfer of human prostacyclin synthase prevents neointimal formation after carotid balloon injury in rats.
Stroke; a journal of cerebral circulation 1999;30(2):419-26.
1998: Nakamura S; Morishita R; Moriguchi A; Yo Y; Nakamura Y; Hayashi S; Matsumoto K; Matsumoto K; Nakamura T; Higaki J; Ogihara T
Hepatocyte growth factor as a potential index of complication in diabetes mellitus.
Journal of hypertension 1998;16(12 Pt 2):2019-26.
1998: Sawa Y; Kaneda Y; Bai H Z; Suzuki K; Fujimoto J; Morishita R; Matsuda H
Efficient transfer of oligonucleotides and plasmid DNA into the whole heart through the coronary artery.
Gene therapy 1998;5(11):1472-80.
1998: Morishita R; Yamada S; Yamamoto K; Tomita N; Kida I; Sakurabayashi I; Kikuchi A; Kaneda Y; Lawn R; Higaki J; Ogihara T
Novel therapeutic strategy for atherosclerosis: ribozyme oligonucleotides against apolipoprotein(a) selectively inhibit apolipoprotein(a) but not plasminogen gene expression.
Circulation 1998;98(18):1898-904.
1998: Yo Y; Morishita R; Nakamura S; Tomita N; Yamamoto K; Moriguchi A; Matsumoto K; Nakamura T; Higaki J; Ogihara T
Potential role of hepatocyte growth factor in the maintenance of renal structure: anti-apoptotic action of HGF on epithelial cells.
Kidney international 1998;54(4):1128-38.
1998: Bai H Z; Sawa Y; Zhang W D; Yamakawa T; Morishita R; Kaneda Y; Matsuda H
Gene transfer to vein graft wall by HVJ-liposome method: time course and localization of gene expression.
The Annals of thoracic surgery 1998;66(3):814-9; discussion 819-20.
1998: Nakano N; Morishita R; Moriguchi A; Nakamura Y; Hayashi S I; Aoki M; Kida I; Matsumoto K; Nakamura T; Higaki J; Ogihara T
Negative regulation of local hepatocyte growth factor expression by angiotensin II and transforming growth factor-beta in blood vessels: potential role of HGF in cardiovascular disease.
Hypertension 1998;32(3):444-51.
1998: Morishita R; Yamada S; Higaki J; Tomita N; Kida I; Aoki M; Moriguchi A; Hayashi S; Sakurabayashi I; Kaneda Y; Ogihara T
Conditioned medium from HepG2 cells transfected with human apolipoprotein(a) gene stimulates growth of human vascular smooth muscle cells: effects of overexpression of human apolipoprotein(a) gene.
Hypertension 1998;32(2):215-22.
1998: Morishita R; Yamamoto K; Yamada S; Matsushita H; Tomita N; Sakurabayashi I; Kaneda Y; Moriguchi A; Higaki J; Ogihara T
Stimulatory effect of lipoprotein (a) on proliferation of human mesangial cells: role of lipoprotein (a) in renal disease.
Biochemical and biophysical research communications 1998;249(2):313-20.
1998: Tomita N; Morishita R; Tomita S; Yamamoto K; Aoki M; Matsushita H; Hayashi S; Higaki J; Ogihara T
Transcription factor decoy for nuclear factor-kappaB inhibits tumor necrosis factor-alpha-induced expression of interleukin-6 and intracellular adhesion molecule-1 in endothelial cells.
Journal of hypertension 1998;16(7):993-1000.
1998: Bai H; Morishita R; Kida I; Yamakawa T; Zhang W; Aoki M; Matsushita H; Noda A; Nagai R; Kaneda Y; Higaki J; Ogihara T; Sawa Y; Matsuda H
Inhibition of intimal hyperplasia after vein grafting by in vivo transfer of human senescent cell-derived inhibitor-1 gene.
Gene therapy 1998;5(6):761-9.
1998: Morishita R; Higaki J; Tomita N; Ogihara T
Application of transcription factor "decoy" strategy as means of gene therapy and study of gene expression in cardiovascular disease.
Circulation research 1998;82(10):1023-8.
1998: Morishita R; Ogihara T
In vivo evaluation of in vitro hypothesis using "gain or loss" of function: functional analysis of renin-angiotensin system.
American journal of hypertension 1998;11(4 Pt 1):507-13.
1998: Matsushita H; Morishita R; Kida I; Aoki M; Hayashi S; Tomita N; Yamamoto K; Moriguchi A; Noda A; Kaneda Y; Higaki J; Ogihara T
Inhibition of growth of human vascular smooth muscle cells by overexpression of p21 gene through induction of apoptosis.
Hypertension 1998;31(1 Pt 2):493-8.
1998: Yo Y; Morishita R; Yamamoto K; Tomita N; Kida I; Hayashi S; Moriguchi A; Kato S; Matsumoto K; Nakamura T; Higaki J; Ogihara T
Actions of hepatocyte growth factor as a local modulator in the kidney: potential role in pathogenesis of renal disease.
Kidney international 1998;53(1):50-8.
1998: Nakamura S; Moriguchi A; Morishita R; Aoki M; Yo Y; Hayashi S; Nakano N; Katsuya T; Nakata S; Takami S; Matsumoto K; Nakamura T; Higaki J; Ogihara T
A novel vascular modulator, hepatocyte growth factor (HGF), as a potential index of the severity of hypertension.
Biochemical and biophysical research communications 1998;242(1):238-43.
1998: Morishita R; Nakamura S; Hayashi S; Aoki M; Matsushita H; Tomita N; Yamamoto K; Moriguchi A; Higaki J; Ogihara T
Contribution of a vascular modulator, hepatocyte growth factor (HGF), to the pathogenesis of cardiovascular disease.
Journal of atherosclerosis and thrombosis 1998;4(3):128-34.
1997: Nakano N; Moriguchi A; Morishita R; Kida I; Tomita N; Matsumoto K; Nakamura T; Higaki J; Ogihara T
Role of angiotensin II in the regulation of a novel vascular modulator, hepatocyte growth factor (HGF), in experimental hypertensive rats.
Hypertension 1997;30(6):1448-54.
1997: Sawa Y; Morishita R; Suzuki K; Kagisaki K; Kaneda Y; Maeda K; Kadoba K; Matsuda H
A novel strategy for myocardial protection using in vivo transfection of cis element 'decoy' against NFkappaB binding site: evidence for a role of NFkappaB in ischemia-reperfusion injury.
Circulation 1997;96(9 Suppl):II-280-4; discussion II-285.
1997: Tomita N; Morishita R; Higaki J; Ogihara T
A novel strategy for gene therapy and gene regulation analysis using transcription factor decoy oligonucleotides.
Experimental nephrology 1997;5(5):429-34.
1997: Morishita R; Higaki J; Hayashi S I; Yo Y; Aoki M; Nakamura S; Moriguchi A; Matsushita H; Matsumoto K; Nakamura T; Ogihara T
Role of hepatocyte growth factor in endothelial regulation: prevention of high D-glucose-induced endothelial cell death by prostaglandins and phosphodiesterase type 3 inhibitor.
Diabetologia 1997;40(9):1053-61.
1997: Morishita R; Sugimoto T; Aoki M; Kida I; Tomita N; Moriguchi A; Maeda K; Sawa Y; Kaneda Y; Higaki J; Ogihara T
In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction.
Nature medicine 1997;3(8):894-9.
1997: Tomita T; Hashimoto H; Tomita N; Morishita R; Lee S B; Hayashida K; Nakamura N; Yonenobu K; Kaneda Y; Ochi T
In vivo direct gene transfer into articular cartilage by intraarticular injection mediated by HVJ (Sendai virus) and liposomes.
Arthritis and rheumatism 1997;40(5):901-6.
1997: Kaneda Y; Morishita R; Dzau V J
Prevention of restenosis by gene therapy.
Annals of the New York Academy of Sciences 1997;811():299-308; discussion 308-10.
1997: Aoki M; Morishita R; Muraishi A; Moriguchi A; Sugimoto T; Maeda K; Dzau V J; Kaneda Y; Higaki J; Ogihara T
Efficient in vivo gene transfer into the heart in the rat myocardial infarction model using the HVJ (Hemagglutinating Virus of Japan)--liposome method.
Journal of molecular and cellular cardiology 1997;29(3):949-59.
1997: Rakugi H; Okamura A; Kamide K; Ohishi M; Sasamura H; Morishita R; Higaki J; Ogihara T
Recognition of tissue- and subtype-specific modulation of angiotensin II receptors using antibodies against AT1 and AT2 receptors.
Hypertension research : official journal of the Japanese Society of Hypertension 1997;20(1):51-5.
1997: Kaneda Y; Morishita R
[Development of in vivo gene transfer methods towards future gene therapy]
Rinsho byori. The Japanese journal of clinical pathology 1997;45(2):99-105.
1997: Aoki M; Morishita R; Higaki J; Moriguchi A; Hayashi S; Matsushita H; Kida I; Tomita N; Sawa Y; Kaneda Y; Ogihara T
Survival of grafts of genetically modified cardiac myocytes transfected with FITC-labeled oligodeoxynucleotides and the beta-galactosidase gene in the noninfarcted area, but not the myocardial infarcted area.
Gene therapy 1997;4(2):120-7.
1997: Aoki M; Morishita R; Higaki J; Moriguchi A; Kida I; Hayashi S; Matsushita H; Kaneda Y; Ogihara T
In vivo transfer efficiency of antisense oligonucleotides into the myocardium using HVJ-liposome method.
Biochemical and biophysical research communications 1997;231(3):540-5.
1997: Morishita R; Nakamura S; Nakamura Y; Aoki M; Moriguchi A; Kida I; Yo Y; Matsumoto K; Nakamura T; Higaki J; Ogihara T
Potential role of an endothelium-specific growth factor, hepatocyte growth factor, on endothelial damage in diabetes.
Diabetes 1997;46(1):138-42.
1997: Morishita R; Aoki M; Nakamura S; Matsushita H; Tomita N; Hayashi S; Moriguchi A; Matsumoto K; Nakamura T; Higaki J; Ogihara T
Potential role of a novel vascular modulator, hepatocyte growth factor (HGF), in cardiovascular disease: characterization and regulation of local HGF system.
Journal of atherosclerosis and thrombosis 1997;4(1):12-9.
1997: Aoki M; Morishita R; Matsushita H; Nakano N; Hayashi S; Tomita N; Yamamoto K; Moriguchi A; Higaki J; Ogihara T
Serum deprivation-induced apoptosis accompanied by up-regulation of p53 and bax in human aortic vascular smooth muscle cells.
Heart and vessels 1997;Suppl 12():71-5.
1996: Yamada K; Moriguchi A; Morishita R; Aoki M; Nakamura Y; Mikami H; Oshima T; Ninomiya M; Kaneda Y; Higaki J; Ogihara T
Efficient oligonucleotide delivery using the HVJ-liposome method in the central nervous system.
The American journal of physiology 1996;271(5 Pt 2):R1212-20.
1996: Hayashi S I; Morishita R; Aoki M; Moriguchi A; Kida I; Nakajima M; Kaneda Y; Higaki J; Ogihara T
In vivo transfer of gene and oligodeoxynucleotides into skin of fetal rats by incubation in amniotic fluid.
Gene therapy 1996;3(10):878-85.
1996: Nakamura Y; Morishita R; Higaki J; Kida I; Aoki M; Moriguchi A; Yamada K; Hayashi S; Yo Y; Nakano H; Matsumoto K; Nakamura T; Ogihara T
Hepatocyte growth factor is a novel member of the endothelium-specific growth factors: additive stimulatory effect of hepatocyte growth factor with basic fibroblast growth factor but not with vascular endothelial growth factor.
Journal of hypertension 1996;14(9):1067-72.
1996: Morishita R; Ogihara T
[Application of decoy strategy]
Nippon rinsho. Japanese journal of clinical medicine 1996;54(9):2583-90.
1996: Nakamura Y; Morishita R; Nakamura S; Aoki M; Moriguchi A; Matsumoto K; Nakamura T; Higaki J; Ogihara T
A vascular modulator, hepatocyte growth factor, is associated with systolic pressure.
Hypertension 1996;28(3):409-13.
1996: Tomita N; Morishita R; Higaki J; Tomita S; Aoki M; Kaneda Y; Ogihara T
Sustained transgene expression by transfection of renin gene into liver of neonates.
Biochemical and biophysical research communications 1996;224(1):43-9.
1996: Tomita N; Morishita R; Higaki J; Tomita S; Aoki M; Ogihara T; Kaneda Y
In vivo gene transfer of insulin gene into neonatal rats by the HVJ-liposome method resulted in sustained transgene expression.
Gene therapy 1996;3(6):477-82.
1996: Morishita R; Higaki J; Tomita N; Aoki M; Moriguchi A; Tamura K; Murakami K; Kaneda Y; Ogihara T
Role of transcriptional cis-elements, angiotensinogen gene-activating elements, of angiotensinogen gene in blood pressure regulation.
Hypertension 1996;27(3 Pt 2):502-7.
1996: Hayashi S; Morishita R; Higaki J; Aoki M; Moriguchi A; Kida I; Yoshiki S; Matsumoto K; Nakamura T; Kaneda Y; Ogihara T
Autocrine-paracrine effects of overexpression of hepatocyte growth factor gene on growth of endothelial cells.
Biochemical and biophysical research communications 1996;220(3):539-45.
1996: Morishita R; Higaki J; Aoki M; Hayashi S; Kida I; Kaneda Y; Ogihara T
Novel strategy of gene therapy in cardiovascular disease with HVJ-liposome method.
Contributions to nephrology 1996;118():254-64.
1995: Tomita N; Morishita R; Higaki J; Tomita S; Aoki M; Kaneda Y; Ogihara T
Effect of angiotensinogen on blood pressure regulation in normotensive rats: application of a loss of function approach.
Journal of hypertension 1995;13(12 Pt 2):1767-74.
1995: Sawa Y; Suzuki K; Bai H Z; Shirakura R; Morishita R; Kaneda Y; Matsuda H
Efficiency of in vivo gene transfection into transplanted rat heart by coronary infusion of HVJ liposome.
Circulation 1995;92(9 Suppl):II479-82.
1995: Hara S; Morishita R; Tone Y; Yokoyama C; Inoue H; Kaneda Y; Ogihara T; Tanabe T
Overexpression of prostacyclin synthase inhibits growth of vascular smooth muscle cells.
Biochemical and biophysical research communications 1995;216(3):862-7.
1995: Nakamura Y; Morishita R; Higaki J; Kida I; Aoki M; Moriguchi A; Yamada K; Hayashi S; Yo Y; Matsumoto K
Expression of local hepatocyte growth factor system in vascular tissues.
Biochemical and biophysical research communications 1995;215(2):483-8.
1995: Morishita R; Higaki J; Nakamura Y; Aoki M; Yamada K; Moriguchi A; Rakugi H; Tomita N; Tomita S; Yu H
Effect of an antihypertensive drug on brain angiotensin II levels in renal and spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology 1995;22(9):665-9.
1995: Kaneda Y; Morishita R; Tomita N
Increased expression of DNA cointroduced with nuclear protein in adult rat liver.
Journal of molecular medicine (Berlin, Germany) 1995;73(6):289-97.
1994: Katahira K; Mikami H; Otsuka A; Moriguchi A; Kohara K; Higashimori K; Okuda N; Nagano M; Morishita R; Ogihara T
Differential control of vascular tone and heart rate by different amino acid neurotransmitters in the rostral ventrolateral medulla of the rat.
Clinical and experimental pharmacology & physiology 1994;21(7):545-56.
1993: Yu H; Rakugi H; Higaki J; Morishita R; Mikami H; Ogihara T
The role of activated vascular angiotensin II generation in vascular hypertrophy in one-kidney, one clip hypertensive rats.
Journal of hypertension 1993;11(12):1347-55.
1993: Tomita N; Higaki J; Kaneda Y; Yu H; Morishita R; Mikami H; Ogihara T
Hypertensive rats produced by in vivo introduction of the human renin gene.
Circulation research 1993;73(5):898-905.
1993: Nakamura F; Nagano M; Higaki J; Higashimori K; Morishita R; Mikami H; Ogihara T
The angiotensin-converting enzyme inhibitor, perindopril, prevents cardiac hypertrophy in low-renin hypertensive rats.
Clinical and experimental pharmacology & physiology 1993;20(3):135-40.
1993: Morishita R; Higaki J; Okunishi H; Nakamura F; Nagano M; Mikami H; Ishii K; Miyazaki M; Ogihara T
Role of tissue renin angiotensin system in two-kidney, one-clip hypertensive rats.
The American journal of physiology 1993;264(3 Pt 2):F510-4.
1993: Morishita R; Higaki J; Nagano M; Nakamura F; Tomita N; Zhao Y; Mikami H; Miyazaki M; Ogihara T
Discrepancy between renin mRNA and plasma renin level in angiotensin-converting enzyme inhibitor-treated rats.
Clinical and experimental pharmacology & physiology 1993;20(1):15-20.
1992: Tomita N; Higaki J; Morishita R; Kato K; Mikami H; Kaneda Y; Ogihara T
Direct in vivo gene introduction into rat kidney.
Biochemical and biophysical research communications 1992;186(1):129-34.
1992: Morishita R; Higaki J; Miyazaki M; Ogihara T
Possible role of the vascular renin-angiotensin system in hypertension and vascular hypertrophy.
Hypertension 1992;19(2 Suppl):II62-7.
1992: Morishita R; Higaki J; Mikami H; Matsukawa N; Ogihara T
Effect of aging on the renin angiotensin system in patients with renovascular hypertension.
Methods and findings in experimental and clinical pharmacology 1992;14(1):17-21.
1992: Morishita R; Higaki J; Nakamura F; Tomita N; Yu H; Nagano M; Mikami H; Ogihara T
Regression of hypertension-induced vascular hypertrophy by an ACE inhibitor and calcium antagonist in the spontaneously hypertensive rat.
Blood pressure. Supplement 1992;3():41-7.
1991: Nakamura F; Nagano M; Higaki J; Higashimori K; Katahira K; Morishita R; Mikami H; Ogihara T
Regression of left ventricular hypertrophy by angiotensin converting enzyme inhibitor in reduced renal mass hypertensive rats.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1991;9(6):S398-9.
1991: Katsuya T; Higaki J; Miki T; Nakura J; Ikegami H; Morishita R; Nagano M; Higashimori K; Nakamura F; Mikami H
Substrain comparison of genetically hypertensive rats using DNA fingerprinting, and genetic analysis of blood pressure in the inbred rats.
The Tohoku journal of experimental medicine 1991;165(4):253-60.
1991: Higaki J; Miya A; Miki T; Morishita R; Mikami H; Takai S; Ogihara T
Contribution of the activation of the ras oncogene to the evolution of aldosterone- and renin-secreting tumors.
Journal of hypertension 1991;9(2):135-7.
1990: Morishita R; Higaki J; Mikami H; Ogihara T
Effect of cyclosporin A on aldosterone production by dispersed rabbit adreno-capsular cells.
Life sciences 1990;46(26):1985-9.
1989: Higaki J; Okuno M; Nakamaru M; Morishita R; Himeno S; Ogihara T
Changes in plasma active renin and prorenin after endoscopic retrograde pancreatography.
Methods and findings in experimental and clinical pharmacology 1989;11(11):703-5.
1989: Higaki J; Morishita R; Ogihara T
Measurements of enzyme activity and immunoreactivity of plasma renin. Limitations of the conventional method for assay of plasma renin catalytic activity.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift für klinische Chemie und klinische Biochemie 1989;27(4):201-4.
1989: Morishita R; Higaki J; Ogihara T
Endothelin stimulates aldosterone biosynthesis by dispersed rabbit adreno-capsular cells.
Biochemical and biophysical research communications 1989;160(2):628-32.

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