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Ryuichi Morishita

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Shuko Takeda; Kazuko Ikimura; Hirohito Nishino; Hiromi Rakugi; Naoyuki Sato; Ryuichi Morishita
Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model.
Mariana Kiomy Osako; Hiromi Rakugi; Munehisa Shimamura; Hideo Shimizu; Masao Yoshizumi; Hiroshi Koriyama; Takashi Miyake; Futoshi Nakagami; Hironori Nakagami; Ryuichi Morishita
Cross-Talk of Receptor Activator of Nuclear Factor-κB Ligand Signaling With Renin-Angiotensin System in Vascular Calcification.
Hiroshi Kusunoki; Hiromi Rakugi; Yoshiaki Taniyama; Ryuichi Morishita
Cardiac and renal protective effects of irbesartan via peroxisome proliferator-activated receptorγ-hepatocyte growth factor pathway independent of angiotensin II Type 1a receptor blockade in mouse model of salt-sensitive hypertension.

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2013: Shuko Takeda; Kazuko Ikimura; Hirohito Nishino; Hiromi Rakugi; Naoyuki Sato; Ryuichi Morishita
Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model.
Neurobiology of aging 2013;34(8):2064-70.
2013: Mariana Kiomy Osako; Hiromi Rakugi; Munehisa Shimamura; Hideo Shimizu; Masao Yoshizumi; Hiroshi Koriyama; Takashi Miyake; Futoshi Nakagami; Hironori Nakagami; Ryuichi Morishita
Cross-Talk of Receptor Activator of Nuclear Factor-κB Ligand Signaling With Renin-Angiotensin System in Vascular Calcification.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(6):1287-96.
2013: Hiroshi Kusunoki; Hiromi Rakugi; Yoshiaki Taniyama; Ryuichi Morishita
Cardiac and renal protective effects of irbesartan via peroxisome proliferator-activated receptorγ-hepatocyte growth factor pathway independent of angiotensin II Type 1a receptor blockade in mouse model of salt-sensitive hypertension.
Journal of the American Heart Association 2013;2(2):e000103.
2013: Hironori Nakagami; Ryuichi Morishita
[The Roles of Calcium and Phosphorus in Cardiovascular Diseases. Hypertension and osteoporosis].
Clinical calcium 2013;23(4):497-503.
2013: Gerardo Rodriguez-Araujo; Tetsuya Shiuchi; Yoichi Takami; Hiroki Hayashi; Issei Komuro; Yasuhiko Minokoshi; Masaki Mori; Ryuichi Morishita; Hironori Nakagami; Yoshikazu Nakaoka; Yasufumi Kaneda
Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway.
Cellular and molecular life sciences : CMLS 2013;70(6):1123-33.
2013: Futoshi Nakagami; Hironori Nakagami; Mariana Kiomy Osako; Hiromi Rakugi; Munehisa Shimamura; Tomohiro Katsuya; Hiroshi Koriyama; Mariko Kyutoku; Takashi Miyake; Ryuichi Morishita
Decrease in blood pressure and regression of cardiovascular complications by angiotensin II vaccine in mice.
PloS one 2013;8(3):e60493.
2013: Hironori Nakagami; Mariana Kiomy Osako; Ryuichi Morishita
Potential Effect of Angiotensin II Receptor Blockade in Adipose Tissue and Bone.
Current pharmaceutical design 2013;19(17):3049-53.
2012: Kazunari Ozaki; Hiromi Rakugi; Natsuki Yasumasa; Hironori Nakagami; Mariana Kiomy Osako; Motokuni Aoki; Hirofumi Makino; Takashi Miyake; Ryuichi Morishita
Therapeutic effect of ribbon-type nuclear factor-κB decoy oligonucleotides in a rat model of inflammatory bowel disease.
Current gene therapy 2012;12(6):484-92.
2012: Kazutaka Shimizu; Yoshiaki Taniyama; Hiromi Rakugi; Fumihiro Sanada; Junya Azuma; Kazuma Iekushi; Masaaki Iwabayashi; Ryuichi Morishita
Hepatocyte growth factor inhibits lipopolysaccharide-induced oxidative stress via epithelial growth factor receptor degradation.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(11):2687-93.
2012: Hirofumi Makino; Toshio Ogihara; Yoshiki Sawa; Keita Yamasaki; Motokuni Aoki; Junya Azuma; Naotaka Hashiya; Yasufumi Kaneda; Ryuichi Morishita
Long-term follow-up evaluation of results from clinical trial using hepatocyte growth factor gene to treat severe peripheral arterial disease.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(10):2503-9.
2012: Munehisa Shimamura; Naoyuki Sato; Ryuichi Morishita
[Internal medicine and neurological diseases: progress in diagnosis and treatment. Topics: V. Dementia and life-style related disease].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2012;101(8):2204-11.
2012: Hironori Nakagami; Tomoyuki Nishikawa; Takashi Shimosato; Katsuto Tamai; Nao Tamura; Kazunori Tomono; Akito Maeda; Masayoshi Mochizuki; Ryuichi Morishita; Toshinori Moriya; Hajime Hibino; Yasufumi Kaneda
Modification of a novel angiogenic peptide, AG30, for the development of novel therapeutic agents.
Journal of cellular and molecular medicine 2012;16(7):1629-39.
2012: Masaaki Iwabayashi; Junya Azuma; Amarnath Chatterjee; Kazuma Iekushi; Keita Okayama; Hiromi Rakugi; Fumihiro Sanada; Yoshiaki Taniyama; Ryuichi Morishita
Inhibition of Lp(a)-induced functional impairment of endothelial cells and endothelial progenitor cells by hepatocyte growth factor.
Biochemical and biophysical research communications 2012;423(1):79-84.
2012: Hiroki Hayashi; Rodriguez Gerardo Araujo; Nobutaka Koibuchi; Hiroshi Koriyama; Akito Maeda; Masaki Mori; Ryuichi Morishita; Hironori Nakagami; Eiji Oiki; Naoyuki Sato; Munehisa Shimamura; Makiko Takeichi; Katsuto Tamai; Yasufumi Kaneda
HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(6):2306-17.
2012: Keita Okayama; Hiromi Rakugi; Fumihiro Sanada; Yoshiaki Taniyama; Junya Azuma; Norio Dosaka; Kazuma Iekushi; Masaaki Iwabayashi; Hiroshi Kusunoki; Ryuichi Morishita
Hepatocyte growth factor reduces cardiac fibrosis by inhibiting endothelial-mesenchymal transition.
Hypertension 2012;59(5):958-65.
2012: Munehisa Shimamura; Yoshiaki Taniyama; Kouji Wakayama; Hironori Nakagami; Naoyuki Sato; Mohammad Allahtavakoli; Naruto Katsuragi; Nobutaka Koibuchi; Mariko Kyutoku; Ryuichi Morishita
Role of central nervous system periostin in cerebral ischemia.
Stroke; a journal of cerebral circulation 2012;43(4):1108-14.
2012: Ryuichi Morishita; Noriaki Nakaya; Masato Odawara; Masayuki Yoshida; Atsuhiro Ichihara; Hiroshige Itakura; Kyoichi Mizuno
Risk factors for cardiovascular events in Japanese patients treated with fluvastatin from the long-term event monitoring (LEM) study.
Current vascular pharmacology 2012;10(2):178-86.
2012: Hiroshi Kusunoki; Junya Azuma; Kazuma Iekushi; Masaaki Iwabayashi; Keita Okayama; Rei Otsu; Hiromi Rakugi; Fumihiro Sanada; Yoshiaki Taniyama; Ryuichi Morishita
Telmisartan exerts renoprotective actions via peroxisome proliferator-activated receptor-γ/hepatocyte growth factor pathway independent of angiotensin II type 1 receptor blockade.
Hypertension 2012;59(2):308-16.
2012: Masaaki Iwabayashi; Hiroshi Kusunoki; Junya Azuma; Amarnath Chatterjee; Kazuma Iekushi; Keita Okayama; Hiromi Rakugi; Fumihiro Sanada; Yoshiaki Taniyama; Ryuichi Morishita
Role of serotonin in angiogenesis: induction of angiogenesis by sarpogrelate via endothelial 5-HT1B/Akt/eNOS pathway in diabetic mice.
Atherosclerosis 2012;220(2):337-42.
2012: Naoyuki Sato; Mitsuru Shinohara; Motoko Shinohara-Noma; Masatoshi Takeda; Shuko Takeda; Gopal Thinakaran; Akio Fukumori; Hizuki Hamada; Mari Mori-Ueda; Masayasu Okochi; Hiromi Rakugi; Ryuichi Morishita
Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs.
PloS one 2012;7(11):e48551.
2012: Yoshiaki Taniyama; Hiromi Rakugi; Junya Azuma; Kazuma Iekushi; Yasuo Kunugiza; Ryuichi Morishita
Therapeutic option of plasmid-DNA based gene transfer.
Current topics in medicinal chemistry 2012;12(15):1630-7.
2012: Shuko Takeda; Kozue Uchio-Yamada; Hisahiro Yu; Atsushi Moriguchi; Hiromi Rakugi; Naoyuki Sato; Ryuichi Morishita
Oral glucose loading modulates plasma β-amyloid level in alzheimer's disease patients: potential diagnostic method for Alzheimer's disease.
Dementia and geriatric cognitive disorders 2012;34(1):25-30.
2012: Munehisa Shimamura; Yoshiaki Taniyama; Hironori Nakagami; Naoyuki Sato; Ryuichi Morishita
Development of nucleic acid drugs for neurological disorders.
Current topics in medicinal chemistry 2012;12(15):1621-9.
2012: Takashi Miyake; Hironori Nakagami; Ryuichi Morishita
Nucleic acid drugs for preventing restenosis after coronary revascularization.
Current topics in medicinal chemistry 2012;12(15):1613-20.
2012: Jun-Ichi Suzuki; Mitsuaki Isobe; Ryuichi Morishita; Ryozo Nagai
Applications of nucleic acid drugs for organ transplantation.
Current topics in medicinal chemistry 2012;12(15):1608-12.
2012: Mariana Kiomy Osako; Hironori Nakagami; Ryuichi Morishita
Modification of decoy oligodeoxynucleotides to achieve the stability and therapeutic efficacy.
Current topics in medicinal chemistry 2012;12(15):1603-7.
2012: Jun-Ichi Suzuki; Ryuichi Morishita
Editorial: a new era of gene therapy.
Current topics in medicinal chemistry 2012;12(15):1593.
2012: Naoyuki Sato; Mitsuru Shinohara; Hiromi Rakugi; Ryuichi Morishita
Dual effects of statins on Aβ metabolism: upregulation of the degradation of APP-CTF and Aβ clearance.
Neuro-degenerative diseases 2012;10(1-4):305-8.
2012: Hironori Nakagami; Munehisa Shimamura; Hideo Shimizu; Takashi Shimosato; Tomohiro Katsuya; Mariana Kiomy Osako; Hiroshi Koriyama; Mariko Kyutoku; Noriko Minobe; Takashi Miyake; Toshinori Moritani; Futoshi Nakagami; Ryuichi Morishita
Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet.
Molecular medicine reports 2012;5(1):37-40.
2011: Naoyuki Sato; Shuko Takeda; Ryuichi Morishita; Hiromi Rakugi
[Anti-hypertensive drugs and prevention of dementia].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 10(Pt 2):186-91.
2011: Jun-Ichi Suzuki; Ryo Watanabe; Yasunobu Hirata; Ryuichi Morishita; Ryozo Nagai; Masahito Ogawa; Mitsuaki Isobe
Autoimmune giant cell myocarditis: clinical characteristics, experimental models and future treatments.
Expert opinion on therapeutic targets 2011;15(10):1163-72.
2011: Yoshiaki Taniyama; Junya Azuma; Masaaki Iwabayashi; Ryuichi Morishita; Hiromi Rakugi
[Therapeutic angiogenesis for coronary artery].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 7():74-9.
2011: Hironori Nakagami; Ryuichi Morishita
Can Forkhead Box P1 be a novel therapeutic target for atherosclerosis?
Atherosclerosis 2011;218(1):26-7.
2011: Kazuma Iekushi; Masaaki Iwabayashi; Nobutaka Koibuchi; Hiroshi Kusunoki; Keita Okayama; Hiromi Rakugi; Fumihiro Sanada; Yoshiaki Taniyama; Junya Azuma; Ryuichi Morishita
Hepatocyte growth factor attenuates transforming growth factor-β-angiotensin II crosstalk through inhibition of the PTEN/Akt pathway.
Hypertension 2011;58(2):190-6.
2011: Mariko Kyutoku; Yoshiaki Taniyama; Naruto Katsuragi; Hideo Shimizu; Yasuo Kunugiza; Kazuma Iekushi; Nobutaka Koibuchi; Fumihiro Sanada; Yoshihiro Oshita; Ryuichi Morishita
Role of periostin in cancer progression and metastasis: inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model.
International journal of molecular medicine 2011;28(2):181-6.
2011: Naoyuki Sato; Shuko Takeda; Kozue Uchio-Yamada; Hironori Ueda; Tomomi Fujisawa; Hiromi Rakugi; Ryuichi Morishita
Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential.
Current aging science 2011;4(2):118-27.
2011: Hironori Nakagami; Ryuichi Morishita
[The cutting-edge of medicine; anti-aging and cardiovascular diseases].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2011;100(6):1677-82.
2011: Shuko Takeda; Naoyuki Sato; Hiromi Rakugi; Ryuichi Morishita
Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function.
Molecular bioSystems 2011;7(6):1822-7.
2011: Hironori Nakagami; Ryuichi Morishita
[Hypertension, CKD and bone metabolism].
Clinical calcium 2011;21(5):685-9.
2011: Wataru Shioyama; Yoshikazu Nakaoka; Kaori Higuchi; Takashi Minami; Yoshiaki Taniyama; Keigo Nishida; Hiroyasu Kidoya; Takashi Sonobe; Hisamichi Naito; Yoh Arita; Takahiro Hashimoto; Tadashi Kuroda; Yasushi Fujio; Mikiyasu Shirai; Nobuyuki Takakura; Ryuichi Morishita; Keiko Yamauchi-Takihara; Tatsuhiko Kodama; Toshio Hirano; Naoki Mochizuki; Issei Komuro
Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling.
Circulation research 2011;108(6):664-75.
2011: Ryuichi Morishita; Hirofumi Makino; Motokuni Aoki; Naotaka Hashiya; Keita Yamasaki; Junya Azuma; Yoshiaki Taniyama; Yoshiki Sawa; Yasufumi Kaneda; Toshio Ogihara
Phase I/IIa clinical trial of therapeutic angiogenesis using hepatocyte growth factor gene transfer to treat critical limb ischemia.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(3):713-20.
2011: Hironori Nakagami; Ryuichi Morishita
Obesity and gastrointestinal hormones-dual effect of angiotensin II receptor blockade and a partial agonist of PPAR-γ.
Current vascular pharmacology 2011;9(2):162-6.
2011: Hironori Nakagami; Mariana K Osako; Ryuichi Morishita
New concept of vascular calcification and metabolism.
Current vascular pharmacology 2011;9(1):124-7.
2011: Ryuichi Morishita
How to evaluate real-world medicine in a Japanese population: important lessons from the JIKEI, CASE-J, KYOTO and VART studies.
Hypertension research : official journal of the Japanese Society of Hypertension 2011;34(1):33-5.
2011: Takashi Miyake; Motokuni Aoki; Mariana K Osako; Munehisa Shimamura; Hironori Nakagami; Ryuichi Morishita
Systemic administration of ribbon-type decoy oligodeoxynucleotide against nuclear factor κB and ets prevents abdominal aortic aneurysm in rat model.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(1):181-7.
2010: Kazuma Iekushi; Yoshiaki Taniyama; Junya Azuma; Fumihiro Sanada; Hiroshi Kusunoki; Toyohiko Yokoi; Nobutaka Koibuchi; Keita Okayama; Hiromi Rakugi; Ryuichi Morishita
Hepatocyte growth factor attenuates renal fibrosis through TGF-β1 suppression by apoptosis of myofibroblasts.
Journal of hypertension 2010;28(12):2454-61.
2010: Munehisa Shimamura; Ryuichi Morishita
[Gene therapy for diabetic microangiopathy].
Nihon rinsho. Japanese journal of clinical medicine 2010;68 Suppl 9():207-11.
2010: Hiroshi Koriyama; Hironori Nakagami; Tomohiro Katsuya; Ken Sugimoto; Hidetoshi Yamashita; Yoichi Takami; Shiro Maeda; Michiaki Kubo; Atsushi Takahashi; Yusuke Nakamura; Toshio Ogihara; Hiromi Rakugi; Yasufumi Kaneda; Ryuichi Morishita
Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.
Journal of atherosclerosis and thrombosis 2010;17(10):1054-62.
2010: Hironori Nakagami; Mariana Kiomy Osako; Futoshi Nakagami; Takashi Shimosato; Noriko Minobe; Toshinori Moritani; Munehisa Shimamura; Takashi Miyake; Hideo Shimizu; Yasushi Takeya; Ryuichi Morishita
Prevention and regression of non-alcoholic steatohepatitis (NASH) in a rat model by metabosartan, telmisartan.
International journal of molecular medicine 2010;26(4):477-81.
2010: Shuko Takeda; Naoyuki Sato; Hiromi Rakugi; Ryuichi Morishita
Plasma beta-amyloid as potential biomarker of Alzheimer disease: possibility of diagnostic tool for Alzheimer disease.
Molecular bioSystems 2010;6(10):1760-6.
2010: Mariana Kiomy Osako; Hironori Nakagami; Nobutaka Koibuchi; Hideo Shimizu; Futoshi Nakagami; Hiroshi Koriyama; Munehisa Shimamura; Takashi Miyake; Hiromi Rakugi; Ryuichi Morishita
Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification.
Circulation research 2010;107(4):466-75.
2010: Yoshiaki Taniyama; Fumihiro Sanada; Keita Okayama; Hiroshi Kusunoki; Ryuichi Morishita
[Gene therapy for vascular disease].
Nihon rinsho. Japanese journal of clinical medicine 2010;68 Suppl 8():641-5.
2010: Daiki Morimoto; Tetsuya Tomita; Shoko Kuroda; Chikahisa Higuchi; Shinichi Kato; Toshikazu Shiba; Hironori Nakagami; Ryuichi Morishita; Hideki Yoshikawa
Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells.
Journal of bone and mineral metabolism 2010;28(4):418-23.
2010: Futoshi Nakagami; Hironori Nakagami; Mariana Kiomy Osako; Masaaki Iwabayashi; Yoshiaki Taniyama; Takefumi Doi; Hideo Shimizu; Munehisa Shimamura; Hiromi Rakugi; Ryuichi Morishita
Estrogen attenuates vascular remodeling in Lp(a) transgenic mice.
Atherosclerosis 2010;211(1):41-7.
2010: Tomohiro Katsuya; Ryuichi Morishita
The challenge of stopping the knocking down of metabolic dominos upstream.
Hypertension research : official journal of the Japanese Society of Hypertension 2010;33(6):529-30.
2010: Yoshiaki Taniyama; Fumihiro Sanada; Ryuichi Morishita
[Therapeutic angiogenesis for diabetes mellitus related ischemic disease].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(5):949-52.
2010: Hiroshi Koriyama; Hironori Nakagami; Tomohiro Katsuya; Hiroshi Akasaka; Shigeyuki Saitoh; Kazuaki Shimamoto; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita; Hiromi Rakugi
Variation in OSBPL10 is associated with dyslipidemia.
Hypertension research : official journal of the Japanese Society of Hypertension 2010;33(5):511-4.
2010: Shuko Takeda; Naoyuki Sato; Kozue Uchio-Yamada; Kyoko Sawada; Takanori Kunieda; Daisuke Takeuchi; Hitomi Kurinami; Mitsuru Shinohara; Hiromi Rakugi; Ryuichi Morishita
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(15):7036-41.
2010: Jun-ichi Suzuki; Masahito Ogawa; Kiyoshi Takayama; Yoshiaki Taniyama; Ryuichi Morishita; Yasunobu Hirata; Ryozo Nagai; Mitsuaki Isobe
Ultrasound-microbubble-mediated intercellular adhesion molecule-1 small interfering ribonucleic acid transfection attenuates neointimal formation after arterial injury in mice.
Journal of the American College of Cardiology 2010;55(9):904-13.
2010: Yoshiaki Taniyama; Ryuichi Morishita
Does therapeutic angiogenesis overcome CKD?
Hypertension research : official journal of the Japanese Society of Hypertension 2010;33(2):114-5.
2010: Jun-ichi Suzuki; Mitsuaki Isobe; Ryuichi Morishita; Ryozo Nagai
Characteristics of chronic rejection in heart transplantation: important elements of pathogenesis and future treatments.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(2):233-9.
2010: Ken Sugimoto; Tomohiro Katsuya; Kei Kamide; Tomomi Fujisawa; Izumi Shimaoka; Mitsuru Ohishi; Ryuichi Morishita; Toshio Ogihara; Hiromi Rakugi
Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study.
International journal of hypertension 2010;2010():196307.
2009: Shuko Takeda; Naoyuki Sato; Daisuke Takeuchi; Hitomi Kurinami; Mitsuru Shinohara; Kazue Niisato; Masanobu Kano; Toshio Ogihara; Hiromi Rakugi; Ryuichi Morishita
Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling.
Hypertension 2009;54(6):1345-52.
2009: Fumihiro Sanada; Yoshiaki Taniyama; Kazuma Iekushi; Junya Azuma; Keita Okayama; Hiroshi Kusunoki; Nobutaka Koibuchi; Takefumi Doi; Yoshifusa Aizawa; Ryuichi Morishita
Negative action of hepatocyte growth factor/c-Met system on angiotensin II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells.
Circulation research 2009;105(7):667-75, 13 p following 675.
2009: Naruya Tomita; Keita Yamasaki; Mariana K Osako; Norio Komai; Takashi Shimosato; Ryuichi Morishita
Combination therapy based on the angiotensin receptor blocker olmesartan for vascular protection in spontaneously hypertensive rats.
Molecular medicine reports 2009;2(5):733-8.
2009: Hideo Shimizu; Hironori Nakagami; Mariana Kiomy Osako; Futoshi Nakagami; Yasuo Kunugiza; Tetsuya Tomita; Hideki Yoshikawa; Hiromi Rakugi; Toshio Ogihara; Ryuichi Morishita
Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(9):786-90.
2009: Hideo Shimizu; Hironori Nakagami; Shosuke Morita; Ikuyo Tsukamoto; Mariana Kiomy Osako; Futoshi Nakagami; Takashi Shimosato; Noriko Minobe; Ryuichi Morishita
New treatment of periodontal diseases by using NF-kappaB decoy oligodeoxynucleotides via prevention of bone resorption and promotion of wound healing.
Antioxidants & redox signaling 2009;11(9):2065-75.
2009: Ryuichi Morishita; Junichi Ishii; Yoshiaki Kusumi; Shingo Yamada; Norio Komai; Minoru Ohishi; Masanori Nomura; Hitoshi Hishida; Mari Niihashi; Masako Mitsumata
Association of serum oxidized lipoprotein(a) concentration with coronary artery disease: potential role of oxidized lipoprotein(a) in the vasucular wall.
Journal of atherosclerosis and thrombosis 2009;16(4):410-8.
2009: Tomohiro Katsuya; Ryuichi Morishita; Hiromi Rakugi; Toshio Ogihrara
Genetic basis of hypertension for the development of tailored medicine.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(8):643-8.
2009: Takashi Miyake; Ryuichi Morishita
Pharmacological treatment of abdominal aortic aneurysm.
Cardiovascular research 2009;83(3):436-43.
2009: Shuko Takeda; Naoyuki Sato; Kozue Uchio-Yamada; Kyoko Sawada; Takanori Kunieda; Daisuke Takeuchi; Hitomi Kurinami; Mitsuru Shinohara; Hiromi Rakugi; Ryuichi Morishita
Elevation of plasma beta-amyloid level by glucose loading in Alzheimer mouse models.
Biochemical and biophysical research communications 2009;385(2):193-7.
2009: Shuko Takeda; Naoyuki Sato; Kazue Niisato; Daisuke Takeuchi; Hitomi Kurinami; Mitsuru Shinohara; Hiromi Rakugi; Masanobu Kano; Ryuichi Morishita
Validation of Abeta1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease.
Brain research 2009;1280():137-47.
2009: Hironori Nakagami; Ryuichi Morishita
[Gene therapy for anti-aging medicine].
Nihon rinsho. Japanese journal of clinical medicine 2009;67(7):1407-11.
2009: Tomohiro Katsuya; Ryuichi Morishita
[WRN gene].
Nihon rinsho. Japanese journal of clinical medicine 2009;67(7):1277-82.
2009: Hironori Nakagami; Ryuichi Morishita
[Hormones and osteoporosis update. Effect of angiotensin II on bone metabolism].
Clinical calcium 2009;19(7):997-1002.
2009: Masaki Mori; Hironori Nakagami; Nobutaka Koibuchi; Koichi Miura; Yoichi Takami; Hiroshi Koriyama; Hiroki Hayashi; Hisataka Sabe; Naoki Mochizuki; Ryuichi Morishita; Yasufumi Kaneda
Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis.
Molecular biology of the cell 2009;20(13):3115-24.
2009: Hiroki Hayashi; Hironori Nakagami; Yoichi Takami; Hiroshi Koriyama; Masaki Mori; Katsuto Tamai; Jianxin Sun; Kaori Nagao; Ryuichi Morishita; Yasufumi Kaneda
FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(6):909-14.
2009: Hironori Nakagami; Mariana Kiomy Osako; Yoichi Takami; Rikinari Hanayama; Hiroshi Koriyama; Masaki Mori; Hiroki Hayashi; Hideo Shimizu; Ryuichi Morishita
Vascular protective effects of ezetimibe in ApoE-deficient mice.
Atherosclerosis 2009;203(1):51-8.
2009: Tomoyuki Nishikawa; Hironori Nakagami; Akito Maeda; Ryuichi Morishita; Nobuhiko Miyazaki; Toshihiro Ogawa; Yasuhiko Tabata; Yasushi Kikuchi; Hiroki Hayashi; Yoshiro Tatsu; Noboru Yumoto; Katsuto Tamai; Kazunori Tomono; Yasufumi Kaneda
Development of a novel antimicrobial peptide, AG-30, with angiogenic properties.
Journal of cellular and molecular medicine 2009;13(3):535-46.
2009: Jun-ichi Suzuki; Mitsuaki Isobe; Ryuichi Morishita; Ryozo Nagai
Nucleic acid drugs for prevention of cardiac rejection.
Journal of biomedicine & biotechnology 2009;2009():916514.
2009: Jun-Ichi Suzuki; Mitsuaki Isobe; Ryuichi Morishita; Ryozo Nagai
Tea polyphenols regulate key mediators on inflammatory cardiovascular diseases.
Mediators of inflammation 2009;2009():494928.
2009: Jun-Ichi Suzuki; Daisuke Tezuka; Ryuichi Morishita; Mitsuaki Isobe
An initial case of suppressed restenosis with nuclear factor-kappa B decoy transfection after percutaneous coronary intervention.
The journal of gene medicine 2009;11(1):89-91.
2008: Yoshikazu Fujiwara; Suguru Shiraya; Takashi Miyake; Satoshi Yamakawa; Motokuni Aoki; Hirofumi Makino; Motonobu Nishimura; Ryuichi Morishita
Inhibition of experimental abdominal aortic aneurysm in a rat model by the angiotensin receptor blocker valsartan.
International journal of molecular medicine 2008;22(6):703-8.
2008: Kouji Wakayama; Munehisa Shimamura; Masataka Sata; Nobutaka Koibuchi; Naoyuki Sato; Toshio Ogihara; Ryuichi Morishita
A model of cerebrovascular injury in rats.
Journal of neuroscience methods 2008;175(2):187-95.
2008: Hironori Nakagami; Mariana Kiomy Osako; Yoichi Takami; Rie Hanayama; Hiroshi Koriyama; Masaki Mori; H Hayashi; Hideo Shimizu; Ryuichi Morishita
Differential response of vascular hepatocyte growth factor concentration and lipid accumulation between telmisartan and losartan in ApoE-deficient mice.
Molecular medicine reports 2008;1(5):657-61.
2008: Takashi Miyake; Motokuni Aoki; Ryuichi Morishita
Inhibition of anastomotic intimal hyperplasia using a chimeric decoy strategy against NFkappaB and E2F in a rabbit model.
Cardiovascular research 2008;79(4):706-14.
2008: Hideo Shimizu; Hironori Nakagami; Mariana Kiomy Osako; Rie Hanayama; Yasuo Kunugiza; Takuji Kizawa; Tetsuya Tomita; Hideki Yoshikawa; Toshio Ogihara; Ryuichi Morishita
Angiotensin II accelerates osteoporosis by activating osteoclasts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(7):2465-75.
2008: Hitomi Kurinami; Naoyuki Sato; Mitsuru Shinohara; Daisuke Takeuchi; Shuko Takeda; Munehisa Shimamura; Toshio Ogihara; Ryuichi Morishita
Prevention of amyloid beta-induced memory impairment by fluvastatin, associated with the decrease in amyloid beta accumulation and oxidative stress in amyloid beta injection mouse model.
International journal of molecular medicine 2008;21(5):531-7.
2008: Kaori Nagao; Yoshiaki Taniyama; Thomas Kietzmann; Takefumi Doi; Issei Komuro; Ryuichi Morishita
HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus.
The Journal of biological chemistry 2008;283(17):11841-9.
2008: D Takeuchi; Naoyuki Sato; Munehisa Shimamura; Hitomi Kurinami; Shin'ichi Takeda; Masahiko Shinohara; S Suzuki; Midori Kojima; Toshio Ogihara; Ryuichi Morishita
Alleviation of Abeta-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model.
Gene therapy 2008;15(8):561-71.
2008: Yukihiro Saito; Hironori Nakagami; Masayuki Kurooka; Yoichi Takami; Yasushi Kikuchi; H Hayashi; Tomoyuki Nishikawa; Katsuto Tamai; Ryuichi Morishita; N Azuma; T Sasajima; Yasufumi Kaneda
Cold shock domain protein A represses angiogenesis and lymphangiogenesis via inhibition of serum response element.
Oncogene 2008;27(13):1821-33.
2008: Naruya Tomita; Keita Yamasaki; Keiko Izawa; Yasuo Kunugiza; Mariana Kiomy Osako; Toshio Ogihara; Ryuichi Morishita
Inhibition of experimental abdominal aortic aneurysm progression by nifedipine.
International journal of molecular medicine 2008;21(2):239-44.
2008: Shuko Takeda; Naoyuki Sato; Toshio Ogihara; Ryuichi Morishita
The renin-angiotensin system, hypertension and cognitive dysfunction in Alzheimer's disease: new therapeutic potential.
Frontiers in bioscience : a journal and virtual library 2008;13():2253-65.
2007: Hironori Nakagami; Yasushi Kikuchi; Tomohiro Katsuya; Ryuichi Morishita; Hiroshi Akasaka; Shigeyuki Saitoh; Hiromi Rakugi; Yasufumi Kaneda; Kazuaki Shimamoto; Toshio Ogihara
Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(12):1239-46.
2007: Munehisa Shimamura; Naoyuki Sato; Masataka Sata; Hitomi Kurinami; Daisuke Takeuchi; Kouji Wakayama; Takuya Hayashi; Hidehiro Iida; Ryuichi Morishita
Delayed postischemic treatment with fluvastatin improved cognitive impairment after stroke in rats.
Stroke; a journal of cerebral circulation 2007;38(12):3251-8.
2007: Takashi Miyake; Motokuni Aoki; Hisao Masaki; Tomio Kawasaki; Masako Oishi; Kazusaburo Kataoka; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappaB and ets in a rabbit model.
Circulation research 2007;101(11):1175-84.
2007: Hiroki Hayashi; Hironori Nakagami; Yoichi Takami; Naoyuki Sato; Yukihiro Saito; Tomoyuki Nishikawa; Masaki Mori; Hiroshi Koriyama; Katsuto Tamai; Ryuichi Morishita; Yasufumi Kaneda
Involvement of gamma-secretase in postnatal angiogenesis.
Biochemical and biophysical research communications 2007;363(3):584-90.
2007: Yoichi Takami; Hironori Nakagami; Ryuichi Morishita; Tomohiro Katsuya; Tai-Xing Cui; Tomonaga Ichikawa; Yukihiro Saito; Hiroki Hayashi; Yasushi Kikuchi; Tomoyuki Nishikawa; Yoshichika Baba; Osamu Yasuda; Hiromi Rakugi; Toshio Ogihara; Yasufumi Kaneda
Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(10):2184-90.
2007: Hirokazu Taniguchi; Yoshiyuki Fujiwara; Yuichiro Doki; Yurika Sugita; Itsuro Sohma; Hiroshi Miyata; Shuji Takiguchi; Takushi Yasuda; Naruya Tomita; Ryuichi Morishita; Morito Monden
Gene therapy using ets-1 transcription factor decoy for peritoneal dissemination of gastric cancer.
International journal of cancer. Journal international du cancer 2007;121(7):1609-17.
2007: Hironori Nakagami; Ryuichi Morishita
Recent progress in therapeutic angiogenesis.
International journal of biomedical science : IJBS 2007;3(3):153-8.
2007: Mariana Kiomy Osako; Naruya Tomita; Hironori Nakagami; Yasuo Kunugiza; Masafumi Yoshino; Kazuhiko Yuyama; Tetsuya Tomita; Hideki Yoshikawa; Toshio Ogihara; Ryuichi Morishita
Increase in nuclease resistance and incorporation of NF-kappaB decoy oligodeoxynucleotides by modification of the 3'-terminus.
The journal of gene medicine 2007;9(9):812-9.
2007: Kaori Nagao; Yoshiaki Taniyama; Nobutaka Koibuchi; Ryuichi Morishita
Constitutive over-expression of VEGF results in reduced expression of Hand-1 during cardiac development in Xenopus.
Biochemical and biophysical research communications 2007;359(3):431-7.
2007: Munehisa Shimamura; Naoyuki Sato; Masataka Sata; Kouji Wakayama; Toshio Ogihara; Ryuichi Morishita
Expression of hepatocyte growth factor and c-Met after spinal cord injury in rats.
Brain research 2007;1151():188-94.
2007: Kazuma Iekushi; Yoshiaki Taniyama; Junya Azuma; Naruto Katsuragi; Norio Dosaka; Fumihiro Sanada; Nobutaka Koibuchi; Kaori Nagao; Toshio Ogihara; Ryuichi Morishita
Novel mechanisms of valsartan on the treatment of acute myocardial infarction through inhibition of the antiadhesion molecule periostin.
Hypertension 2007;49(6):1409-14.
2007: Naruya Tomita; Keita Yamasaki; Keiko Izawa; Yasuo Kunugiza; Mariana Kiomy Osako; Toshio Ogihara; Ryuichi Morishita
Improvement of organ damage by a non-depressor dose of imidapril in diabetic spontaneously hypertensive rats.
International journal of molecular medicine 2007;19(4):571-9.
2007: Naruya Tomita; Naoki Kashihara; Ryuichi Morishita
Transcription factor decoy oligonucleotide-based therapeutic strategy for renal disease.
Clinical and experimental nephrology 2007;11(1):7-17.
2007: Kouji Wakayama; Munehisa Shimamura; Masataka Sata; Naoyuki Sato; Koji Kawakami; Hirotsugu Fukuda; Takuji Tomimatsu; Toshio Ogihara; Ryuichi Morishita
Quantitative measurement of neurological deficit after mild (30 min) transient middle cerebral artery occlusion in rats.
Brain research 2007;1130(1):181-7.
2006: Hiromi Koike; A Ishida; Munehisa Shimamura; Shinya Mizuno; Tadashi Nakamura; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease.
Gene therapy 2006;13(23):1639-44.
2006: Kazunari Ozaki; Ryuichi Morishita; Toshio Ogihara
[Overview on diagnosis, treatment and therapeutic angiogenesis for arteriosclerosis obliterans].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(11):2045-51.
2006: Suguru Shiraya; Ken Miwa; Motokuni Aoki; Takashi Miyake; Masako Oishi; Kazusaburo Kataoka; Shigetsugu Ohgi; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
Hypertension accelerated experimental abdominal aortic aneurysm through upregulation of nuclear factor kappaB and Ets.
Hypertension 2006;48(4):628-36.
2006: Yukihiro Saito; Hironori Nakagami; Ryuichi Morishita; Yoichi Takami; Yasushi Kikuchi; Hiroki Hayashi; Tomoyuki Nishikawa; Katsuto Tamai; Nobuyoshi Azuma; Tadahiro Sasajima; Yasufumi Kaneda
Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis.
Circulation 2006;114(11):1177-84.
2006: Takashi Miyake; Motokuni Aoki; Suguru Shiraya; Kazuo Tanemoto; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
Inhibitory effects of NFkappaB decoy oligodeoxynucleotides on neointimal hyperplasia in a rabbit vein graft model.
Journal of molecular and cellular cardiology 2006;41(3):431-40.
2006: Tetsuya Tomita; Yasuo Kunugiza; Naruya Tomita; Hiroshi Takano; Ryuichi Morishita; Yasufumi Kaneda; Hideki Yoshikawa
E2F decoy oligodeoxynucleotide ameliorates cartilage invasion by infiltrating synovium derived from rheumatoid arthritis.
International journal of molecular medicine 2006;18(2):257-65.
2006: Junya Azuma; Yoshiaki Taniyama; Y Takeya; Kazuma Iekushi; Motokuni Aoki; N Dosaka; Kunihiro Matsumoto; Tadashi Nakamura; Toshio Ogihara; Ryuichi Morishita
Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy.
Gene therapy 2006;13(16):1206-13.
2006: Yasuo Kunugiza; Naruya Tomita; Yoshiaki Taniyama; Tetsuya Tomita; Mariana Kiomy Osako; Katsuto Tamai; Tadashi Tanabe; Yasufumi Kaneda; Hideki Yoshikawa; Ryuichi Morishita
Acceleration of wound healing by combined gene transfer of hepatocyte growth factor and prostacyclin synthase with Shima Jet.
Gene therapy 2006;13(15):1143-52.
2006: Ryuichi Morishita
[Gene therapy for hypertension].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():565-70.
2006: Hironori Nakagami; Namika Nakagawa; Yasushi Takeya; Katsunobu Kashiwagi; Chisato Ishida; Shin-ichiro Hayashi; Motokuni Aoki; Kunio Matsumoto; Toshikazu Nakamura; Toshio Ogihara; Ryuichi Morishita
Model of vasculogenesis from embryonic stem cells for vascular research and regenerative medicine.
Hypertension 2006;48(1):112-9.
2006: H Shimizu; Hironori Nakagami; I Tsukamoto; S Morita; Yasuo Kunugiza; Tetsuya Tomita; Hideki Yoshikawa; Yasufumi Kaneda; Toshio Ogihara; Ryuichi Morishita
NFkappaB decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclasts.
Gene therapy 2006;13(12):933-41.
2006: Naoyuki Sato; Masayasu Okochi; Yoshiaki Taniyama; Hitomi Kurinami; Munehisa Shimamura; Daisuke Takeuchi; Hizuki Hamada; Akio Fukumori; Kazuyuki Kiyosue; Takahisa Taguchi; Toshiyuki Tanaka; Masayuki Miyasaka; Masatoshi Takeda; Toshio Ogihara; Ryuichi Morishita
Development of new screening system for Alzheimer disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils.
Neurobiology of disease 2006;22(3):487-95.
2006: Nobutaka Koibuchi; Yoshiaki Taniyama; Kaori Nagao; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
The effect of VEGF on blood vessels and blood cells during Xenopus development.
Biochemical and biophysical research communications 2006;344(1):339-45.
2006: Hironori Nakagami; Ryuichi Morishita; Kazuhisa Maeda; Yasushi Kikuchi; Toshio Ogihara; Yasufumi Kaneda
Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy.
Journal of atherosclerosis and thrombosis 2006;13(2):77-81.
2006: Hironori Nakagami; Naruya Tomita; Yasufumi Kaneda; Toshio Ogihara; Ryuichi Morishita
Anti-oxidant gene therapy by NF kappa B decoy oligodeoxynucleotide.
Current pharmaceutical biotechnology 2006;7(2):95-100.
2006: Motokuni Aoki; Ryuichi Morishita
[Therapeutic angiogenesis for ischemic diseases].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(4):762-8.
2006: Tomoyuki Nishikawa; Hironori Nakagami; Atsushi Matsuki; Akito Maeda; Chiah Yian Yo; Taku Harada; Ryuichi Morishita; Katsuto Tamai; Yasufumi Kaneda
Development of high-throughput functional screening of therapeutic genes, using a hemagglutinating virus of Japan envelope vector.
Human gene therapy 2006;17(4):470-5.
2006: Munehisa Shimamura; Naoyuki Sato; Satoshi Waguri; Yasuo Uchiyama; Takuya Hayashi; Hidehiro Iida; Toshikazu Nakamura; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction.
Hypertension 2006;47(4):742-51.
2006: Takashi Miyake; Motokuni Aoki; H Nakashima; T Kawasaki; Masako Oishi; Kazusaburo Kataoka; Kazuo Tanemoto; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
Prevention of abdominal aortic aneurysms by simultaneous inhibition of NFkappaB and ets using chimeric decoy oligonucleotides in a rabbit model.
Gene therapy 2006;13(8):695-704.
2006: Ryuichi Morishita; Naruya Tomita
[Effect of nifedipine on organ protection: potential application in patients with aortic aneurysm].
Drugs 2006;66 Spec No 1():31-3.
2006: Yasuo Kunugiza; Tetsuya Tomita; Naruya Tomita; Ryuichi Morishita; Hideki Yoshikawa
Inhibitory effect of ribbon-type NF-kappaB decoy oligodeoxynucleotides on osteoclast induction and activity in vitro and in vivo.
Arthritis research & therapy 2006;8(4):R103.
2006: Hiroshi Inagaki; Jun-ichi Suzuki; Masahito Ogawa; Yoshiaki Taniyama; Ryuichi Morishita; Mitsuaki Isobe
Ultrasound-microbubble-mediated NF-kappaB decoy transfection attenuates neointimal formation after arterial injury in mice.
Journal of vascular research 2006;43(1):12-8.
2006: Munehisa Shimamura; Naoyuki Sato; Shinichi Yoshimura; Yasufumi Kaneda; Ryuichi Morishita
HVJ-based non-viral gene transfer method: successful gene therapy using HGF and VEGF genes in experimental ischemia.
Frontiers in bioscience : a journal and virtual library 2006;11():753-9.
2005: Ryuichi Morishita
A scientific rationale for the CREST trial results: evidence for the mechanism of action of cilostazol in restenosis.
Atherosclerosis. Supplements 2005;6(4):41-6.
2005: Katsuto Tamai; Yasufumi Kaneda; Hiroshige Nakamura; Motohiro Aoki; Ryuichi Morishita; Koji Hashimoto; Akimichi Morita; Ichiro Katayama; Katsumi Hanada
[NFkappaB decoy DNA for treatment of atopic dermatitis].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():659-63.
2005: Yoshiaki Taniyama; Ryuichi Morishita; Hiroshi Makino; Junya Azuma; Toshio Ogihara
[Gene therapy in congestive heart failure].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():594-7.
2005: Yoshiaki Taniyama; Ryuichi Morishita; Junya Azuma; Kazuma Iekushi
[Therapeutic angiogenesis for ischemic heart disease induced by gene transfer].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():588-93.
2005: Hirofumi Makino; Toshio Ogihara; Ryuichi Morishita
[Gene therapy for peripheral arterial disease].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():582-7.
2005: Hironori Nkagami; Yasufumi Kaneda; Ryuichi Morishita
[Future view of gene therapy in cardiovascular field].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():577-81.
2005: Hironori Nakagami; Kazuhisa Maeda; Ryuichi Morishita; Sota Iguchi; Tomoyuki Nishikawa; Yoichi Takami; Yasushi Kikuchi; Yukihiro Saito; Katsuto Tamai; Toshio Ogihara; Yasufumi Kaneda
Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(12):2542-7.
2005: Munehisa Shimamura; Naoyuki Sato; Yoshiaki Taniyama; Hitomi Kurinami; Hiroyuki Tanaka; Toshihiro Takami; Toshio Ogihara; Masaya Tohyama; Yasufumi Kaneda; Ryuichi Morishita
Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubbles.
The journal of gene medicine 2005;7(11):1468-74.
2005: Naoyuki Sato; Munehisa Shimamura; Ryuichi Morishita
Recent progress in cerebrovascular gene therapy.
Current neurovascular research 2005;2(3):235-47.
2005: Hirofumi Makino; Motokuni Aoki; Naotaka Hashiya; Keita Yamasaki; Hideo Shimizu; Ken Miwa; Toshio Ogihara; Ryuichi Morishita
A calcium-channel blocker, benidipine, improves forearm reactive hyperemia in patients with essential hypertension.
Blood pressure. Supplement 2005;1():39-44.
2005: Ken Miwa; H Nakashima; Motokuni Aoki; Takashi Miyake; T Kawasaki; M Iwai; Masako Oishi; Kazusaburo Kataoka; Shigetsugu Ohgi; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
Inhibition of ets, an essential transcription factor for angiogenesis, to prevent the development of abdominal aortic aneurysm in a rat model.
Gene therapy 2005;12(14):1109-18.
2005: Yoshiaki Taniyama; Ryuichi Morishita; Junya Azuma; Kazuma Iekushi; Toshio Ogihara
[Gene therapy for diabetic microangiopathy].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 6():153-8.
2005: Hironori Nakagami; Yasufumi Kaneda; Toshio Ogihara; Ryuichi Morishita
Hepatocyte growth factor as potential cardiovascular therapy.
Expert review of cardiovascular therapy 2005;3(3):513-9.
2005: Ryuichi Morishita; Motokuni Aoki; Toshio Ogihara
Does gene therapy become pharmacotherapy?
Experimental physiology 2005;90(3):307-13.
2005: Hirofumi Makino; Toshio Ogihara; Ryuichi Morishita
[Gene therapy for peripheral arterial diseases].
Nihon rinsho. Japanese journal of clinical medicine 2005;63(3):491-7.
2005: Naotaka Hashiya; Toshio Ogihara; Ryuichi Morishita
[Practice of gene therapy].
Nihon rinsho. Japanese journal of clinical medicine 2005;63(3):370-2.
2005: Hironori Nakagami; Yasufumi Kaneda; Toshio Ogihara; Ryuichi Morishita
Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis.
Current diabetes reviews 2005;1(1):59-63.
2005: Hiromi Koike; Naruya Tomita; Haruhito Azuma; Yoshiaki Taniyama; Keita Yamasaki; Yasuo Kunugiza; Katsuro Tachibana; Toshio Ogihara; Ryuichi Morishita
An efficient gene transfer method mediated by ultrasound and microbubbles into the kidney.
The journal of gene medicine 2005;7(1):108-16.
2004: Naruya Tomita; Haruhito Azuma; Yasufumi Kaneda; Toshio Ogihara; Ryuichi Morishita
Application of decoy oligodeoxynucleotides-based approach to renal diseases.
Current drug targets 2004;5(8):717-33.
2004: Kazuya Hiraoka; Seiji Yamamoto; Satoru Otsuru; Seiji Nakai; Katsuto Tamai; Ryuichi Morishita; Toshio Ogihara; Yasufumi Kaneda
Enhanced tumor-specific long-term immunity of hemagglutinating [correction of hemaggluttinating] virus of Japan-mediated dendritic cell-tumor fused cell vaccination by coadministration with CpG oligodeoxynucleotides.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4297-307.
2004: Kei Yamamoto; Naruya Tomita; Shin-ichi Yoshimura; Hironori Nakagami; Yoshiaki Taniyama; Keita Yamasaki; Toshio Ogihara; Ryuichi Morishita
Hypoxia-induced renal epithelial cell death through caspase-dependent pathway: role of Bcl-2, Bcl-xL and Bax in tubular injury.
International journal of molecular medicine 2004;14(4):633-40.
2004: Munehisa Shimamura; Naoyuki Sato; Yoshiaki Taniyama; S Yamamoto; M Endoh; Hitomi Kurinami; Motokuni Aoki; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound.
Gene therapy 2004;11(20):1532-9.
2004: Keita Yamasaki; Motokuni Aoki; Hirofumi Makino; Naotaka Hashiya; Hideo Shimizu; Mitsuru Ohishi; Toshio Ogihara; Ryuichi Morishita
Effect of nifedipine on endothelial function in normotensive smokers: potential contribution of increase in circulating hepatocyte growth factor.
Journal of human hypertension 2004;18(10):701-5.
2004: Ryuichi Morishita; Motokuni Aoki; Naotaka Hashiya; Hirofumi Makino; Keita Yamasaki; Junya Azuma; Yoshiki Sawa; Hikaru Matsuda; Yasufumi Kaneda; Toshio Ogihara
Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease.
Hypertension 2004;44(2):203-9.
2004: Naotaka Hashiya; Nobuo Jo; Motokuni Aoki; Kunio Matsumoto; Toshikazu Nakamura; Yasufumi Sato; Nahoko Ogata; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
In vivo evidence of angiogenesis induced by transcription factor Ets-1: Ets-1 is located upstream of angiogenesis cascade.
Circulation 2004;109(24):3035-41.
2004: Ryuichi Morishita; Motokuni Aoki; Naotaka Hashiya; Keita Yamasaki; Hitomi Kurinami; Shiro Shimizu; Hirofumi Makino; Yasushi Takesya; Junya Azuma; Toshio Ogihara
Therapeutic angiogenesis using hepatocyte growth factor (HGF).
Current gene therapy 2004;4(2):199-206.
2004: Hironori Nakagami; Ryuichi Morishita; Tomoyuki Nishikawa; Hideo Shimizu; Sota Iguchi; Kunio Matsumoto; Toshikazu Nakamura; Yasufumi Kaneda; Toshio Ogihara
Lack of association between the hepatocyte growth factor receptor, c-met, and the anti-apoptotic action of bag-1 in endothelial cells.
Hypertension research : official journal of the Japanese Society of Hypertension 2004;27(5):359-65.
2004: Ryuichi Morishita
Perspective in progress of cardiovascular gene therapy.
Journal of pharmacological sciences 2004;95(1):1-8.
2004: Naruya Tomita; John Y S Kim; Gary H Gibbons; Lunan Zhang; Yasufumi Kaneda; Rolf A K Stahl; Malcom Ogborn; Benoit Venderville; Ryuichi Morishita; Dana Baran; Victor J Dzau
Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis.
International journal of molecular medicine 2004;13(5):629-36.
2004: Nobutaka Koibuchi; Yasufumi Kaneda; Yoshiaki Taniyama; Kunio Matsumoto; Toshikazu Nakamura; Toshio Ogihara; Ryuichi Morishita
Essential role of HGF (hepatocyte growth factor) in blood formation in Xenopus.
Blood 2004;103(9):3320-5.
2004: Naotaka Hashiya; Motokuni Aoki; Katsuro Tachibana; Yoshiaki Taniyama; Keita Yamasaki; Kazuya Hiraoka; Hirofumi Makino; Kaneda Yasufumi; Toshio Ogihara; Ryuichi Morishita
Local delivery of E2F decoy oligodeoxynucleotides using ultrasound with microbubble agent (Optison) inhibits intimal hyperplasia after balloon injury in rat carotid artery model.
Biochemical and biophysical research communications 2004;317(2):508-14.
2004: Ryuichi Morishita; Naruya Tomita; Yasufumi Kaneda; Toshio Ogihara
Molecular therapy to inhibit NFkappaB activation by transcription factor decoy oligonucleotides.
Current opinion in pharmacology 2004;4(2):139-46.
2004: Atsushi Matsuki; Seiji Yamamoto; Hironori Nakagami; Motokuni Aoki; Katsuto Tamai; Kunio Matsumoto; Toshikazu Nakamura; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
No influence of tumor growth by intramuscular injection of hepatocyte growth factor plasmid DNA: safety evaluation of therapeutic angiogenesis gene therapy in mice.
Biochemical and biophysical research communications 2004;315(1):59-65.
2004: Hirofumi Makino; Motokuni Aoki; Naotaka Hashiya; Keita Yamasaki; Kazuya Hiraoka; Hideo Shimizu; Junya Azuma; Hitomi Kurinami; Toshio Ogihara; Ryuichi Morishita
Increase in peripheral blood flow by intravenous administration of prostaglandin E1 in patients with peripheral arterial disease, accompanied by up-regulation of hepatocyte growth factor.
Hypertension research : official journal of the Japanese Society of Hypertension 2004;27(2):85-91.
2004: Munehisa Shimamura; Naoyuki Sato; Kazuo Oshima; Motokuni Aoki; Hitomi Kurinami; Satoshi Waguri; Yasuo Uchiyama; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
Novel therapeutic strategy to treat brain ischemia: overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model.
Circulation 2004;109(3):424-31.
2004: Hideki Nakashima; Motokuni Aoki; Takashi Miyake; Tomio Kawasaki; Masahiro Iwai; Nobuo Jo; Masako Oishi; Kazusaburo Kataoka; Shigetsugu Ohgi; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors.
Circulation 2004;109(1):132-8.
2004: Yoshiaki Taniyama; Naruya Tomita; Seiji Endoh; Yasufumi Kaneda; Toshio Ogihara; Ryuichi Morishita
[Gene transfer with ultrasound and microbubbles (optison) as a potential treatment for cardiovascular diseases].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2004;41(1):51-4.
2004: Kazuo Oshima; Munehisa Shimamura; Shinya Mizuno; Katsuto Tamai; Katsumi Doi; Ryuichi Morishita; Toshikazu Nakamura; Takeshi Kubo; Yasufumi Kaneda
Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate hearing impairment in rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):212-4.
2003: Kazuya Hiraoka; Hiromi Koike; Seiji Yamamoto; Naruya Tomita; Chieko Yokoyama; Tadashi Tanabe; Takashi Aikou; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
Enhanced therapeutic angiogenesis by cotransfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA.
Circulation 2003;108(21):2689-96.
2003: Tsunetatsu Namba; Hiromi Koike; Kazushi Murakami; Motokuni Aoki; Hirofumi Makino; Naotaka Hashiya; Toshio Ogihara; Yasufumi Kaneda; Masakazu Kohno; Ryuichi Morishita
Angiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model.
Circulation 2003;108(18):2250-7.
2003: Motokuni Aoki; Ryuichi Morishita; Toshio Ogihara
Oligonucleotide-based molecular therapy for restenosis after angioplasty.
Current drug targets 2003;4(8):613-8.
2003: Naruya Tomita; Toshio Ogihara; Ryuichi Morishita
Transcription factors as molecular targets: molecular mechanisms of decoy ODN and their design.
Current drug targets 2003;4(8):603-8.
2003: Ryuichi Morishita
Transcription factor as molecular targets: is transcription factor decoy a novel drug?
Current drug targets 2003;4(8):2 p before 599.
2003: Naruya Tomita; Toshio Ogihara; Ryuichi Morishita
Therapeutic potential of decoy oligonucleotides strategy in cardiovascular diseases.
Expert review of cardiovascular therapy 2003;1(3):463-70.
2003: Shin-ichiro Hayashi; Junya Azuma; Toshio Ogihara; Ryuichi Morishita
[Gene therapy for myocardial regeneration].
Nihon rinsho. Japanese journal of clinical medicine 2003;61(5):867-70.
2003: Naruya Tomita; Haruhito Azuma; Yasufumi Kaneda; Toshio Ogihara; Ryuichi Morishita
Gene therapy with transcription factor decoy oligonucleotides as a potential treatment for cardiovascular diseases.
Current drug targets 2003;4(4):339-46.
2003: Naruya Tomita; Tetsuya Tomita; Kazuhiko Yuyama; Takahiro Tougan; Tsuyoshi Tajima; Toshio Ogihara; Ryuichi Morishita
Development of novel decoy oligonucleotides: advantages of circular dumb-bell decoy.
Current opinion in molecular therapeutics 2003;5(2):107-12.
2003: Hirofumi Makino; Toshio Ogihara; Ryuichi Morishita
[Therapeutic angiogenesis by angiogenic growth factor].
Nihon rinsho. Japanese journal of clinical medicine 2003;61 Suppl 4():692-7.
2003: Motokuni Aoki; Toshio Ogihara; Ryuichi Morishita
[Gene therapy for restenosis after angioplasty].
Nihon rinsho. Japanese journal of clinical medicine 2003;61 Suppl 4():685-91.
2003: Hiromi Koike; Ryuichi Morishita; Sota Iguchi; Motokuni Aoki; Kunio Matsumoto; Toshikazu Nakamura; Chieko Yokoyama; Tadashi Tanabe; Toshio Ogihara; Yasufumi Kaneda
Enhanced angiogenesis and improvement of neuropathy by cotransfection of human hepatocyte growth factor and prostacyclin synthase gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):779-81.
2003: Naruya Tomita; Ryuichi Morishita; Yoshiaki Taniyama; Hiromi Koike; Motokuni Aoki; Hideo Shimizu; Kunio Matsumoto; Toshikazu Nakamura; Yasufumi Kaneda; Toshio Ogihara
Angiogenic property of hepatocyte growth factor is dependent on upregulation of essential transcription factor for angiogenesis, ets-1.
Circulation 2003;107(10):1411-7.
2003: Ryuichi Morishita
Cardiovascular disease and angiogenesis.
Internal medicine (Tokyo, Japan) 2003;42(3):301-2.
2003: Keiko Matsumoto; Ryuichi Morishita; Naruya Tomita; Atsushi Moriguchi; Norio Komai; Motokuni Aoki; Kunio Matsumoto; Toshikazu Nakamura; Jitsuo Higaki; Toshio Ogihara
Improvement of endothelial dysfunction by angiotensin II blockade accompanied by induction of vascular hepatocyte growth factor system in diabetic spontaneously hypertensive rats.
Heart and vessels 2003;18(1):18-25.
2003: Seiji Yamamoto; Tomoki Yamano; Maki Tanaka; Dave S B Hoon; Sonshin Takao; Ryuichi Morishita; Takashi Aikou; Yasufumi Kaneda
A novel combination of suicide gene therapy and histone deacetylase inhibitor for treatment of malignant melanoma.
Cancer gene therapy 2003;10(3):179-86.
2003: Keita Yamasaki; T Asai; M Shimizu; Motokuni Aoki; Naotaka Hashiya; H Sakonjo; Hirofumi Makino; Yasufumi Kaneda; Toshio Ogihara; Ryuichi Morishita
Inhibition of NFkappaB activation using cis-element 'decoy' of NFkappaB binding site reduces neointimal formation in porcine balloon-injured coronary artery model.
Gene therapy 2003;10(4):356-64.
2003: Munehisa Shimamura; Ryuichi Morishita; Masayuki Endoh; Kazuo Oshima; Motokuni Aoki; Satoshi Waguri; Yasuo Uchiyama; Yasufumi Kaneda
HVJ-envelope vector for gene transfer into central nervous system.
Biochemical and biophysical research communications 2003;300(2):464-71.
2003: Ryuichi Morishita; Yasufumi Kaneda; Toshio Ogihara
Therapeutic potential of oligonucleotide-based therapy in cardiovascular disease.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2003;17(6):383-9.
2003: M Nakabayashi; Ryuichi Morishita; Hironori Nakagami; K Kuba; Kunihiro Matsumoto; Tadashi Nakamura; Yasuo Tano; Yasufumi Kaneda
HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model.
Diabetologia 2003;46(1):115-23.
2002: Ryuichi Morishita
Recent progress in gene therapy for cardiovascular disease.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(12):1077-86.
2002: Ryuichi Morishita; Gary H Gibbons; Y Kaneda; L Zhang; Toshio Ogihara; Victor J Dzau
Apolipoprotein E-deficient mice created by systemic administration of antisense oligodeoxynucleotides: a new model for lipoprotein metabolism studies.
The Journal of endocrinology 2002;175(2):475-85.
2002: Hirofumi Makino; Toshio Ogihara; Ryuichi Morishita
[Gene therapy for peripheral arterial diseases in diabetes mellitus].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 10():449-56.
2002: Ryuichi Morishita
[Gene therapy in cardiovascular medicine as new pharmacological therapy].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2002;120(4):222-8.
2002: Kunihiro Matsumoto; Ryuichi Morishita; N Tomita; A Moriguchi; Keita Yamasaki; Motokuni Aoki; K Matsumoto; Tadashi Nakamura; J Higaki; Toshio Ogihara
Impaired endothelial dysfunction in diabetes mellitus rats was restored by oral administration of prostaglandin I2 analogue.
The Journal of endocrinology 2002;175(1):217-23.
2002: Ryuichi Morishita; Naruya Tomita; Toshio Ogihara
HMG-Co A reductase inhibitors in the treatment of cardiovascular diseases: stabilization of coronary artery plaque.
Current drug targets 2002;3(5):379-85.
2002: Motokuni Aoki; Toshio Ogihara; Ryuichi Morishita
[The latest review of therapeutic angiogenesis using angiogenic growth factors to peripheral arterial diseases].
Nihon rinsho. Japanese journal of clinical medicine 2002;60(9):1845-55.
2002: Naruya Tomita; Ryuichi Morishita; Kei Yamamoto; Jitsuo Higaki; Victor J Dzau; Toshio Ogihara; Yasufumi Kaneda
Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomes.
The journal of gene medicine 2002;4(5):527-35.
2002: Hideji Nakamura; Motokuni Aoki; Katsuto Tamai; Masako Oishi; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
Prevention and regression of atopic dermatitis by ointment containing NF-kB decoy oligodeoxynucleotides in NC/Nga atopic mouse model.
Gene therapy 2002;9(18):1221-9.
2002: Norio Komai; Ryuichi Morishita; Shingo Yamada; Mitsuru Oishi; Sota Iguchi; Motokuni Aoki; Minako Sasaki; Ikunosuke Sakurabayashi; Jitsuo Higaki; Toshio Ogihara
Mitogenic activity of oxidized lipoprotein (a) on human vascular smooth muscle cells.
Hypertension 2002;40(3):310-4.
2002: Yasufumi Kaneda; Toshihiro Nakajima; Tomoyuki Nishikawa; Seiji Yamamoto; Hiroyuki Ikegami; Naho Suzuki; Hitomi Nakamura; Ryuichi Morishita; Hitoshi Kotani
Hemagglutinating virus of Japan (HVJ) envelope vector as a versatile gene delivery system.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(2):219-26.
2002: Hironori Nakagami; Ryuichi Morishita; Kei Yamamoto; Yoshiaki Taniyama; Motokuni Aoki; Keita Yamasaki; Kunio Matsumoto; Toshikazu Nakamura; Yasufumi Kaneda; Toshio Ogihara
Hepatocyte growth factor prevents endothelial cell death through inhibition of bax translocation from cytosol to mitochondrial membrane.
Diabetes 2002;51(8):2604-11.
2002: Naruya Tomita; Ryuichi Morishita; Hiromi Koike; Masahide Hashizume; Mitsue Notake; Buichi Fujitani; Yasufumi Kaneda; Masatsugu Horiuchi; Toshio Ogihara
Therapeutic approach to familial hypercholesterolemia by HVJ-liposomes in LDL receptor knockout mouse.
International journal of molecular medicine 2002;10(2):137-43.
2002: Yoshiaki Taniyama; Ryuichi Morishita; Motokuni Aoki; Kazuya Hiraoka; Keita Yamasaki; Naotaka Hashiya; Kunio Matsumoto; Toshikazu Nakamura; Yasufumi Kaneda; Toshio Ogihara
Angiogenesis and antifibrotic action by hepatocyte growth factor in cardiomyopathy.
Hypertension 2002;40(1):47-53.
2002: Ryuichi Morishita; Motokuni Aoki; Yoshikage Yo; Toshio Ogihara
Hepatocyte growth factor as cardiovascular hormone: role of HGF in the pathogenesis of cardiovascular disease.
Endocrine journal 2002;49(3):273-84.
2002: Norio Komai; Mitsuru Ohishi; Ryuichi Morishita; Atsushi Moriguchi; Masaharu Kaibe; Keiko Matsumoto; Hiromi Rakugi; Jitsuo Higaki; Toshio Ogihara
Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients.
American journal of hypertension 2002;15(6):499-506.
2002: Naruya Tomita; Ryuichi Morishita; Toshio Ogihara
[Pharmacological effects of HMG-CoA reductase inhibitors].
Nihon rinsho. Japanese journal of clinical medicine 2002;60(5):955-61.
2002: Masaki Mori; Hironori Nakagami; Ryuichi Morishita; Noriaki Mitsuda; Kei Yamamoto; Shin-ichi Yoshimura; Nobutaka Ohkubo; Naoyuki Sato; Toshio Ogihara; Yasufumi Kaneda
N141I mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression.
Life sciences 2002;70(21):2567-80.
2002: Naruya Tomita; Ryuichi Morishita; Tetsuya Tomita; Toshio Ogihara
Potential therapeutic applications of decoy oligonucleotides.
Current opinion in molecular therapeutics 2002;4(2):166-70.
2002: Tadashi Nakamura; Ryuichi Morishita; T Asai; N Tsuboniwa; Motokuni Aoki; H Sakonjo; Keita Yamasaki; Naotaka Hashiya; Yasufumi Kaneda; Toshio Ogihara
Molecular strategy using cis-element 'decoy' of E2F binding site inhibits neointimal formation in porcine balloon-injured coronary artery model.
Gene therapy 2002;9(8):488-94.
2002: Ryuichi Morishita; Minako Sakaki; Kei Yamamoto; Sota Iguchi; Motokuni Aoki; Keita Yamasaki; Kunio Matsumoto; Toshikazu Nakamura; Richard Lawn; Toshio Ogihara; Yasufumi Kaneda
Impairment of collateral formation in lipoprotein(a) transgenic mice: therapeutic angiogenesis induced by human hepatocyte growth factor gene.
Circulation 2002;105(12):1491-6.
2002: Yoshiaki Taniyama; Katsuro Tachibana; Kazuya Hiraoka; Tsunetatsu Namba; Keita Yamasaki; Naotaka Hashiya; Motokuni Aoki; Toshio Ogihara; Kaneda Yasufumi; Ryuichi Morishita
Local delivery of plasmid DNA into rat carotid artery using ultrasound.
Circulation 2002;105(10):1233-9.
2002: Yoshiaki Taniyama; K Tachibana; Kazuya Hiraoka; Motokuni Aoki; Seiji Yamamoto; Kunihiro Matsumoto; Tadashi Nakamura; Toshio Ogihara; Yasufumi Kaneda; Ryuichi Morishita
Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle.
Gene therapy 2002;9(6):372-80.
2002: Hiroshige Nakamura; Ryuichi Morishita; Yasufumi Kaneda
Molecular therapy via transcriptional regulation with double-stranded oligodeoxynucleotides as decoys.
In vivo (Athens, Greece) 2002;16(1):45-8.
2002: Ryuichi Morishita; Yasufumi Kaneda
HVJ (hemagglutinating virus of Japan; Sendai virus)-liposome method.
Methods in enzymology 2002;346():619-27.
2001: Ryuichi Morishita; Motokuni Aoki; Yasufumi Kaneda
Decoy oligodeoxynucleotides as novel cardiovascular drugs for cardiovascular disease.
Annals of the New York Academy of Sciences 2001;947():294-301; discussion 301-2.
2001: Motokuni Aoki; Toshio Ogihara; Ryuichi Morishita
[HGF as a key molecule in cardiovascular diseases].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(12):2460-9.
2001: Yoshiaki Taniyama; Ryuichi Morishita; Kazuya Hiraoka; Motokuni Aoki; Hironori Nakagami; Keita Yamasaki; Kunihiro Matsumoto; Tadashi Nakamura; Yasufumi Kaneda; Toshio Ogihara
Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model: molecular mechanisms of delayed angiogenesis in diabetes.
Circulation 2001;104(19):2344-50.
2001: T Miyata; Seiji Yamamoto; K Sakamoto; Ryuichi Morishita; Yasufumi Kaneda
Novel immunotherapy for peritoneal dissemination of murine colon cancer with macrophage inflammatory protein-1beta mediated by a tumor-specific vector, HVJ cationic liposomes.
Cancer gene therapy 2001;8(11):852-60.
2001: Ryuichi Morishita; Motokuni Aoki; Yasufumi Kaneda; Toshio Ogihara
Gene therapy in vascular medicine: recent advances and future perspectives.
Pharmacology & therapeutics 2001;91(2):105-14.
2001: Motokuni Aoki; Ryuichi Morishita; Seiji Hayashi; Nobuo Jo; Kunihiro Matsumoto; Tadashi Nakamura; Yasufumi Kaneda; Toshio Ogihara
Inhibition of neointimal formation after balloon injury by cilostazol, accompanied by improvement of endothelial dysfunction and induction of hepatocyte growth factor in rat diabetes model.
Diabetologia 2001;44(8):1034-42.
2001: T Otomo; Satoru Yamamoto; Ryuichi Morishita; Yasufumi Kaneda
EBV replicon vector system enhances transgene expression in vivo: applications to cancer gene therapy.
The journal of gene medicine 2001;3(4):345-52.
2001: Motokuni Aoki; T Nata; Ryuichi Morishita; H Matsushita; Hironori Nakagami; Kazuhiro Yamamoto; K Yamazaki; M Nakabayashi; Toshio Ogihara; Yasufumi Kaneda
Endothelial apoptosis induced by oxidative stress through activation of NF-kappaB: antiapoptotic effect of antioxidant agents on endothelial cells.
Hypertension 2001;38(1):48-55.
2001: Hironori Nakagami; Ryuichi Morishita; Kazuhiro Yamamoto; S I Yoshimura; Yoshiaki Taniyama; Motokuni Aoki; H Matsubara; S Kim; Yasufumi Kaneda; Toshio Ogihara
Phosphorylation of p38 mitogen-activated protein kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells.
Diabetes 2001;50(6):1472-81.
2001: Kazuhiro Yamamoto; Ryuichi Morishita; Seiji Hayashi; H Matsushita; Hironori Nakagami; Atsushi Moriguchi; Kunihiro Matsumoto; Tadashi Nakamura; Yasufumi Kaneda; Toshio Ogihara
Contribution of Bcl-2, but not Bcl-xL and Bax, to antiapoptotic actions of hepatocyte growth factor in hypoxia-conditioned human endothelial cells.
Hypertension 2001;37(5):1341-8.
2001: N Tsuboniwa; Ryuichi Morishita; T Hirano; J Fujimoto; S Furukawa; M Kikumori; Akihiko Okuyama; Yasufumi Kaneda
Safety evaluation of hemagglutinating virus of Japan--artificial viral envelope liposomes in nonhuman primates.
Human gene therapy 2001;12(5):469-87.
2001: Naruya Tomita; Ryuichi Morishita; Toshio Ogihara
[Ongoing clinical trials by vascular statin, cerivastatin].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 3():477-82.
2001: Yoshiaki Taniyama; Ryuichi Morishita; Motokuni Aoki; Hironori Nakagami; Kazuhiro Yamamoto; K Yamazaki; Kunihiro Matsumoto; Tadashi Nakamura; Yasufumi Kaneda; Toshio Ogihara
Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease.
Gene therapy 2001;8(3):181-9.
2001: Jitsuo Higaki; Tomohiro Katsuya; Ryuichi Morishita; Toshio Ogihara
Symposium on the etiology of hypertension--summarizing studies in 20th century. 1. Hypertension and genes.
Internal medicine (Tokyo, Japan) 2001;40(2):144-7.
2001: Hironori Nakagami; Ryuichi Morishita; Kazuhiro Yamamoto; Yoshiaki Taniyama; Motokuni Aoki; Kunihiro Matsumoto; Tadashi Nakamura; Yasufumi Kaneda; M Horiuchi; Toshio Ogihara
Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells.
Hypertension 2001;37(2 Pt 2):581-6.
2001: Kunihiro Matsumoto; Ryuichi Morishita; Atsushi Moriguchi; Naruya Tomita; Motokuni Aoki; H Sakonjo; K Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
Inhibition of neointima by angiotensin-converting enzyme inhibitor in porcine coronary artery balloon-injury model.
Hypertension 2001;37(2):270-4.
2001: Naruya Tomita; Ryuichi Morishita; S Tomita; Yasufumi Kaneda; J Higaki; Toshio Ogihara; M Horiuchi
Inhibition of TNF-alpha, induced cytokine and adhesion molecule. Expression in glomerular cells in vitro and in vivo by transcription factor decoy for NFkappaB.
Experimental nephrology 2001;9(3):181-90.
2001: Motokuni Aoki; Ryuichi Morishita; Toshio Ogihara
[Gene therapy for arteriosclerotic diseases].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(1):43-52.
2000: M Kawauchi; Jun-Ichi Suzuki; Ryuichi Morishita; Y Wada; A Izawa; N Tomita; J Amano; Yasufumi Kaneda; Toshio Ogihara; Shinichi Takamoto; Mitsuaki Isobe
Gene therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and nonhuman primates.
Circulation research 2000;87(11):1063-8.
2000: Noritoshi Nagaya; Chieko Yokoyama; Shingo Kyotani; Manabu Shimonishi; Ryuichi Morishita; Masaaki Uematsu; T Nishikimi; Norifumi Nakanishi; Toshio Ogihara; M Yamagishi; Kunio Miyatake; Yasufumi Kaneda; Tadashi Tanabe
Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats.
Circulation 2000;102(16):2005-10.
2000: K Hayashi; Shun Nakamura; Ryuichi Morishita; Atsushi Moriguchi; Motokuni Aoki; Kunihiro Matsumoto; Tadashi Nakamura; Yasufumi Kaneda; Naohiko Sakai; Toshio Ogihara
In vivo transfer of human hepatocyte growth factor gene accelerates re-endothelialization and inhibits neointimal formation after balloon injury in rat model.
Gene therapy 2000;7(19):1664-71.
2000: Hironori Nakagami; Ryuichi Morishita; Kazuhiro Yamamoto; Yoshiaki Taniyama; Motokuni Aoki; S Kim; Kunihiro Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
Anti-apoptotic action of hepatocyte growth factor through mitogen-activated protein kinase on human aortic endothelial cells.
Journal of hypertension 2000;18(10):1411-20.
2000: Kazuhiro Yamamoto; Ryuichi Morishita; Naruya Tomita; T Shimozato; Hironori Nakagami; A Kikuchi; Motokuni Aoki; Jitsuo Higaki; Yasufumi Kaneda; Toshio Ogihara
Ribozyme oligonucleotides against transforming growth factor-beta inhibited neointimal formation after vascular injury in rat model: potential application of ribozyme strategy to treat cardiovascular disease.
Circulation 2000;102(11):1308-14.
2000: Naruya Tomita; Ryuichi Morishita; S Tomita; Gary H Gibbons; L Zhang; M Horiuchi; Yasufumi Kaneda; Jitsuo Higaki; Toshio Ogihara; Victor J Dzau
Transcription factor decoy for NFkappaB inhibits TNF-alpha-induced cytokine and adhesion molecule expression in vivo.
Gene therapy 2000;7(15):1326-32.
2000: Yoshiaki Taniyama; Ryuichi Morishita; Hironori Nakagami; Atsushi Moriguchi; H Sakonjo; Kunihiro Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamsters.
Circulation 2000;102(2):246-52.
2000: Ryuichi Morishita; Gary H Gibbons; Yasufumi Kaneda; Toshio Ogihara; Victor J Dzau
Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose level in diabetic mouse: A model of gene therapy.
Biochemical and biophysical research communications 2000;273(2):666-74.
2000: Ryuichi Morishita; Motokuni Aoki; Yasufumi Kaneda
Oligonucleotide-based gene therapy for cardiovascular disease: are oligonucleotide therapeutics novel cardiovascular drugs?
Current drug targets 2000;1(1):15-23.
2000: Naruya Tomita; Ryuichi Morishita; H Y Lan; Kazuhiro Yamamoto; M Hashizume; M Notake; K Toyosawa; Buichi Fujitani; W Mu; D J Nikolic-Paterson; R C Atkins; Yasufumi Kaneda; Jitsuo Higaki; Toshio Ogihara
In vivo administration of a nuclear transcription factor-kappaB decoy suppresses experimental crescentic glomerulonephritis.
Journal of the American Society of Nephrology : JASN 2000;11(7):1244-52.
2000: Tomoki Yamano; Kiyoe Ura; Ryuichi Morishita; H Nakajima; Morito Monden; Yasufumi Kaneda
Amplification of transgene expression in vitro and in vivo using a novel inhibitor of histone deacetylase.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(6):574-80.
2000: H Matsushita; Ryuichi Morishita; T Nata; Motokuni Aoki; Hironori Nakagami; Yoshiaki Taniyama; K Yamamoto; Jitsuo Higaki; Kaneda Yasufumi; Toshio Ogihara
Hypoxia-induced endothelial apoptosis through nuclear factor-kappaB (NF-kappaB)-mediated bcl-2 suppression: in vivo evidence of the importance of NF-kappaB in endothelial cell regulation.
Circulation research 2000;86(9):974-81.
2000: Ryuichi Morishita; Motokuni Aoki; Shun Nakamura; Jitsuo Higaki; Yasufumi Kaneda; Toshio Ogihara
Gene therapy for cardiovascular disease using hepatocyte growth factor.
Annals of the New York Academy of Sciences 2000;902():369-76.
2000: Mitsuaki Isobe; Jun-Ichi Suzuki; Ryuichi Morishita; Y Kaneda; J Amano
Gene therapy for heart transplantation-associated coronary arteriosclerosis.
Annals of the New York Academy of Sciences 2000;902():77-83.
2000: Ryuichi Morishita; Gary H Gibbons; Naruya Tomita; L Zhang; Yasufumi Kaneda; Toshio Ogihara; Victor J Dzau
Antisense oligodeoxynucleotide inhibition of vascular angiotensin-converting enzyme expression attenuates neointimal formation: evidence for tissue angiotensin-converting enzyme function.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(4):915-22.
2000: H Matsushita; Ryuichi Morishita; Motokuni Aoki; Naruya Tomita; Yoshiaki Taniyama; Hironori Nakagami; T Shimozato; Jitsuo Higaki; Yasufumi Kaneda; Toshio Ogihara
Transfection of antisense p53 tumor suppressor gene oligodeoxynucleotides into rat carotid artery results in abnormal growth of vascular smooth muscle cells.
Circulation 2000;101(12):1447-52.
2000: Ryuichi Morishita
[Oligonucleotide-based therapy as a potential new pharmacotherapy].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2000;115(3):123-30.
2000: Ryuichi Morishita; Motokuni Aoki; Toshio Ogihara
Functional analysis of cardiovascular renin-angiotensin system using a gain or loss of function approach.
Hypertension research : official journal of the Japanese Society of Hypertension 2000;23(2):137-41.
2000: Motokuni Aoki; Ryuichi Morishita; Yoshiaki Taniyama; Iwao Kida; Atsushi Moriguchi; Kunihiro Matsumoto; Tadashi Nakamura; Yasufumi Kaneda; Jitsuo Higaki; Toshio Ogihara
Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: up-regulation of essential transcription factor for angiogenesis, ets.
Gene therapy 2000;7(5):417-27.
2000: Yasufumi Kaneda; Yukihiko Saeki; Masao Nakabayashi; WZ Zhou; M W Kaneda; Ryuichi Morishita
Enhancement of transgene expression by cotransfection of oriP plasmid with EBNA-1 expression vector.
Human gene therapy 2000;11(3):471-9.
2000: Jitsuo Higaki; M Aoki; Ryuichi Morishita; Iwao Kida; Y Taniyama; Naruya Tomita; K Yamamoto; Atsushi Moriguchi; Yasufumi Kaneda; Toshio Ogihara
In vivo evidence of the importance of cardiac angiotensin-converting enzyme in the pathogenesis of cardiac hypertrophy.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(2):428-34.
2000: Motokuni Aoki; Ryuichi Morishita; Yoshiaki Taniyama; Yasufumi Kaneda; Toshio Ogihara
Therapeutic angiogenesis induced by hepatocyte growth factor: potential gene therapy for ischemic diseases.
Journal of atherosclerosis and thrombosis 2000;7(2):71-6.
2000: Naruya Tomita; Ryuichi Morishita; Jitsuo Higaki; Toshio Ogihara
Novel molecular therapeutic approach to cardiovascular disease based on hepatocyte growth factor.
Journal of atherosclerosis and thrombosis 2000;7(1):1-7.
2000: Seiji Hayashi; Ryuichi Morishita; H Matsushita; Hironori Nakagami; Yoshiaki Taniyama; Tadashi Nakamura; Motokuni Aoki; Kazuhiro Yamamoto; Jitsuo Higaki; Toshio Ogihara
Cyclic AMP inhibited proliferation of human aortic vascular smooth muscle cells, accompanied by induction of p53 and p21.
Hypertension 2000;35(1 Pt 2):237-43.
1999: Tetsuya Tomita; Eiji Takeuchi; Naruya Tomita; Ryuichi Morishita; Motoharu Kaneko; Kazuhiro Yamamoto; Takanobu Nakase; H Seki; K Kato; Yasufumi Kaneda; Takahiro Ochi
Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy.
Arthritis and rheumatism 1999;42(12):2532-42.
1999: Seiji Hayashi; Ryuichi Morishita; Shun Nakamura; Kazuhiro Yamamoto; Atsushi Moriguchi; T Nagano; Mutsuo Taiji; H Noguchi; Kunihiro Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
Potential role of hepatocyte growth factor, a novel angiogenic growth factor, in peripheral arterial disease: downregulation of HGF in response to hypoxia in vascular cells.
Circulation 1999;100(19 Suppl):II301-8.
1999: WZ Zhou; Dave S B Hoon; S K Huang; S Fujii; K Hashimoto; Ryuichi Morishita; Yasufumi Kaneda
RNA melanoma vaccine: induction of antitumor immunity by human glycoprotein 100 mRNA immunization.
Human gene therapy 1999;10(16):2719-24.
1999: WZ Zhou; Yasufumi Kaneda; S Huang; Ryuichi Morishita; Dave S B Hoon
Protective immunization against melanoma by gp100 DNA-HVJ-liposome vaccine.
Gene therapy 1999;6(10):1768-73.
1999: Yasufumi Kaneda; Ryuichi Morishita
[Gene therapy of cardiovascular disorders].
Human cell 1999;12(3):109-14.
1999: Ryuichi Morishita; Atsushi Moriguchi; Jitsuo Higaki; Toshio Ogihara
Hepatocyte growth factor (HGF) as a potential index of severity of hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 1999;22(3):161-7.
1999: T Nishii; A Moriguchi; Ryuichi Morishita; K Yamada; S Nakamura; N Tomita; Yasufumi Kaneda; A Fukamizu; H Mikami; Jitsuo Higaki; Toshio Ogihara
Angiotensinogen gene-activating elements regulate blood pressure in the brain.
Circulation research 1999;85(3):257-63.
1999: Shun Nakamura; Atsushi Moriguchi; Ryuichi Morishita; K Yamada; T Nishii; Naruya Tomita; Mitsuru Ohishi; Yasufumi Kaneda; Jitsuo Higaki; Toshio Ogihara
Activation of the brain angiotensin system by in vivo human angiotensin-converting enzyme gene transfer in rats.
Hypertension 1999;34(2):302-8.
1999: Kunihiro Matsumoto; Ryuichi Morishita; Atsushi Moriguchi; Naruya Tomita; Yoshikage Yo; T Nishii; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
Prevention of renal damage by angiotensin II blockade, accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats.
Hypertension 1999;34(2):279-84.
1999: Motokuni Aoki; Ryuichi Morishita; H Matsushita; Seiji Hayashi; Hironori Nakagami; Kazuhiro Yamamoto; Atsushi Moriguchi; Yasufumi Kaneda; Jitsuo Higaki; Toshio Ogihara
Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells. Potential role of p53 in regulation of vascular smooth muscle cell growth.
Hypertension 1999;34(2):192-200.
1999: Iwao Kida; Ryuichi Morishita; Toshio Ogihara
[A new medical treatment for thrombosis by genetic engineering].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(7):1519-25.
1999: Yasufumi Kaneda; Yukihiko Saeki; Ryuichi Morishita
Gene therapy using HVJ-liposomes: the best of both worlds?
Molecular medicine today 1999;5(7):298-303.
1999: Ryuichi Morishita; Shun Nakamura; Seiji Hayashi; Yoshiaki Taniyama; Atsushi Moriguchi; T Nagano; Mutsuo Taiji; H Noguchi; S Takeshita; Kunihiro Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy.
Hypertension 1999;33(6):1379-84.
1999: Tatemi Todaka; Chieko Yokoyama; Hiroji Yanamoto; Nobuo Hashimoto; Izumi Nagata; T Tsukahara; Shuntaro Hara; Toshihisa Hatae; Ryuichi Morishita; Motokuni Aoki; Toshio Ogihara; Yasufumi Kaneda; Tadashi Tanabe
Gene transfer of human prostacyclin synthase prevents neointimal formation after carotid balloon injury in rats.
Stroke; a journal of cerebral circulation 1999;30(2):419-26.
1998: Shun Nakamura; Ryuichi Morishita; Atsushi Moriguchi; Yoshikage Yo; Y Nakamura; Seiji Hayashi; Kunihiro Matsumoto; K Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
Hepatocyte growth factor as a potential index of complication in diabetes mellitus.
Journal of hypertension 1998;16(12 Pt 2):2019-26.
1998: Ryuichi Morishita; Shingo Yamada; Kazuhiro Yamamoto; Naruya Tomita; Iwao Kida; Ikunosuke Sakurabayashi; A Kikuchi; Yasufumi Kaneda; R Lawn; Jitsuo Higaki; Toshio Ogihara
Novel therapeutic strategy for atherosclerosis: ribozyme oligonucleotides against apolipoprotein(a) selectively inhibit apolipoprotein(a) but not plasminogen gene expression.
Circulation 1998;98(18):1898-904.
1998: Yoshiki Sawa; Yasufumi Kaneda; HZ Bai; K Suzuki; J Fujimoto; Ryuichi Morishita; Hikaru Matsuda
Efficient transfer of oligonucleotides and plasmid DNA into the whole heart through the coronary artery.
Gene therapy 1998;5(11):1472-80.
1998: Yoshikage Yo; Ryuichi Morishita; Shun Nakamura; Naruya Tomita; Kazuhiro Yamamoto; Atsushi Moriguchi; Kunihiro Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
Potential role of hepatocyte growth factor in the maintenance of renal structure: anti-apoptotic action of HGF on epithelial cells.
Kidney international 1998;54(4):1128-38.
1998: HZ Bai; Yoshiki Sawa; W D Zhang; T Yamakawa; Ryuichi Morishita; Yasufumi Kaneda; Hikaru Matsuda
Gene transfer to vein graft wall by HVJ-liposome method: time course and localization of gene expression.
The Annals of thoracic surgery 1998;66(3):814-9; discussion 819-20.
1998: N Nakano; Ryuichi Morishita; Atsushi Moriguchi; Y Nakamura; Seiji Hayashi; Motokuni Aoki; Iwao Kida; Kunihiro Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
Negative regulation of local hepatocyte growth factor expression by angiotensin II and transforming growth factor-beta in blood vessels: potential role of HGF in cardiovascular disease.
Hypertension 1998;32(3):444-51.
1998: Ryuichi Morishita; Kazuhiro Yamamoto; Shingo Yamada; H Matsushita; Naruya Tomita; Ikunosuke Sakurabayashi; Yasufumi Kaneda; Atsushi Moriguchi; Jitsuo Higaki; Toshio Ogihara
Stimulatory effect of lipoprotein (a) on proliferation of human mesangial cells: role of lipoprotein (a) in renal disease.
Biochemical and biophysical research communications 1998;249(2):313-20.
1998: Ryuichi Morishita; Shingo Yamada; Jitsuo Higaki; Naruya Tomita; Iwao Kida; Motokuni Aoki; Atsushi Moriguchi; Seiji Hayashi; Ikunosuke Sakurabayashi; Yasufumi Kaneda; Toshio Ogihara
Conditioned medium from HepG2 cells transfected with human apolipoprotein(a) gene stimulates growth of human vascular smooth muscle cells: effects of overexpression of human apolipoprotein(a) gene.
Hypertension 1998;32(2):215-22.
1998: Naruya Tomita; Ryuichi Morishita; S Tomita; Kazuhiro Yamamoto; Motokuni Aoki; H Matsushita; Seiji Hayashi; Jitsuo Higaki; Toshio Ogihara
Transcription factor decoy for nuclear factor-kappaB inhibits tumor necrosis factor-alpha-induced expression of interleukin-6 and intracellular adhesion molecule-1 in endothelial cells.
Journal of hypertension 1998;16(7):993-1000.
1998: H Bai; Ryuichi Morishita; Iwao Kida; T Yamakawa; W Zhang; Motokuni Aoki; H Matsushita; A Noda; R Nagai; Yasufumi Kaneda; Jitsuo Higaki; Toshio Ogihara; Yoshiki Sawa; Hikaru Matsuda
Inhibition of intimal hyperplasia after vein grafting by in vivo transfer of human senescent cell-derived inhibitor-1 gene.
Gene therapy 1998;5(6):761-9.
1998: Ryuichi Morishita; Jitsuo Higaki; N Tomita; Toshio Ogihara
Application of transcription factor "decoy" strategy as means of gene therapy and study of gene expression in cardiovascular disease.
Circulation research 1998;82(10):1023-8.
1998: Ryuichi Morishita; Toshio Ogihara
In vivo evaluation of in vitro hypothesis using "gain or loss" of function: functional analysis of renin-angiotensin system.
American journal of hypertension 1998;11(4 Pt 1):507-13.
1998: Shun Nakamura; Atsushi Moriguchi; Ryuichi Morishita; Motokuni Aoki; Yoshikage Yo; Seiji Hayashi; N Nakano; Tomohiro Katsuya; S Nakata; S Takami; Kunihiro Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
A novel vascular modulator, hepatocyte growth factor (HGF), as a potential index of the severity of hypertension.
Biochemical and biophysical research communications 1998;242(1):238-43.
1998: Ryuichi Morishita; Shun Nakamura; Seiji Hayashi; Motokuni Aoki; H Matsushita; Naruya Tomita; Kazuhiro Yamamoto; Atsushi Moriguchi; Jitsuo Higaki; Toshio Ogihara
Contribution of a vascular modulator, hepatocyte growth factor (HGF), to the pathogenesis of cardiovascular disease.
Journal of atherosclerosis and thrombosis 1998;4(3):128-34.
1998: H Matsushita; Ryuichi Morishita; Iwao Kida; Motokuni Aoki; Seiji Hayashi; Naruya Tomita; Kazuhiro Yamamoto; Atsushi Moriguchi; A Noda; Yasufumi Kaneda; Jitsuo Higaki; Toshio Ogihara
Inhibition of growth of human vascular smooth muscle cells by overexpression of p21 gene through induction of apoptosis.
Hypertension 1998;31(1 Pt 2):493-8.
1998: Yoshikage Yo; Ryuichi Morishita; Kazuhiro Yamamoto; Naruya Tomita; Iwao Kida; Seiji Hayashi; Atsushi Moriguchi; S Kato; Kunihiro Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
Actions of hepatocyte growth factor as a local modulator in the kidney: potential role in pathogenesis of renal disease.
Kidney international 1998;53(1):50-8.
1997: N Nakano; Atsushi Moriguchi; Ryuichi Morishita; Iwao Kida; Naruya Tomita; Kunihiro Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
Role of angiotensin II in the regulation of a novel vascular modulator, hepatocyte growth factor (HGF), in experimental hypertensive rats.
Hypertension 1997;30(6):1448-54.
1997: Yoshiki Sawa; Ryuichi Morishita; K Suzuki; Koji Kagisaki; Yasufumi Kaneda; Kazuhisa Maeda; K Kadoba; Hikaru Matsuda
A novel strategy for myocardial protection using in vivo transfection of cis element 'decoy' against NFkappaB binding site: evidence for a role of NFkappaB in ischemia-reperfusion injury.
Circulation 1997;96(9 Suppl):II-280-4; discussion II-285.
1997: Naruya Tomita; Ryuichi Morishita; J Higaki; Toshio Ogihara
A novel strategy for gene therapy and gene regulation analysis using transcription factor decoy oligonucleotides.
Experimental nephrology 1997;5(5):429-34.
1997: Ryuichi Morishita; Jitsuo Higaki; Seiji Hayashi; Yoshikage Yo; Motokuni Aoki; Shun Nakamura; Atsushi Moriguchi; H Matsushita; Kunihiro Matsumoto; Tadashi Nakamura; Toshio Ogihara
Role of hepatocyte growth factor in endothelial regulation: prevention of high D-glucose-induced endothelial cell death by prostaglandins and phosphodiesterase type 3 inhibitor.
Diabetologia 1997;40(9):1053-61.
1997: Ryuichi Morishita; T Sugimoto; Motokuni Aoki; Iwao Kida; Naruya Tomita; Atsushi Moriguchi; K Maeda; Yoshiki Sawa; Yasufumi Kaneda; Jitsuo Higaki; Toshio Ogihara
In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction.
Nature medicine 1997;3(8):894-9.
1997: Tetsuya Tomita; Hideo Hashimoto; Naruya Tomita; Ryuichi Morishita; S B Lee; K Hayashida; Norimasa Nakamura; Kazuo Yonenobu; Yasufumi Kaneda; Takahiro Ochi
In vivo direct gene transfer into articular cartilage by intraarticular injection mediated by HVJ (Sendai virus) and liposomes.
Arthritis and rheumatism 1997;40(5):901-6.
1997: Yasufumi Kaneda; Ryuichi Morishita; Victor J Dzau
Prevention of restenosis by gene therapy.
Annals of the New York Academy of Sciences 1997;811():299-308; discussion 308-10.
1997: Motokuni Aoki; Ryuichi Morishita; A Muraishi; Atsushi Moriguchi; T Sugimoto; K Maeda; Victor J Dzau; Yasufumi Kaneda; Jitsuo Higaki; Toshio Ogihara
Efficient in vivo gene transfer into the heart in the rat myocardial infarction model using the HVJ (Hemagglutinating Virus of Japan)--liposome method.
Journal of molecular and cellular cardiology 1997;29(3):949-59.
1997: Hiromi Rakugi; Atsunori Okamura; Kei Kamide; Mitsuru Ohishi; H Sasamura; Ryuichi Morishita; Jitsuo Higaki; Toshio Ogihara
Recognition of tissue- and subtype-specific modulation of angiotensin II receptors using antibodies against AT1 and AT2 receptors.
Hypertension research : official journal of the Japanese Society of Hypertension 1997;20(1):51-5.
1997: Motokuni Aoki; Ryuichi Morishita; Jitsuo Higaki; Atsushi Moriguchi; Iwao Kida; Seiji Hayashi; H Matsushita; Yasufumi Kaneda; Toshio Ogihara
In vivo transfer efficiency of antisense oligonucleotides into the myocardium using HVJ-liposome method.
Biochemical and biophysical research communications 1997;231(3):540-5.
1997: Yasufumi Kaneda; Ryuichi Morishita
[Development of in vivo gene transfer methods towards future gene therapy].
Rinsho byori. The Japanese journal of clinical pathology 1997;45(2):99-105.
1997: Motokuni Aoki; Ryuichi Morishita; Jitsuo Higaki; Atsushi Moriguchi; Seiji Hayashi; H Matsushita; Iwao Kida; Naruya Tomita; Yoshiki Sawa; Yasufumi Kaneda; Toshio Ogihara
Survival of grafts of genetically modified cardiac myocytes transfected with FITC-labeled oligodeoxynucleotides and the beta-galactosidase gene in the noninfarcted area, but not the myocardial infarcted area.
Gene therapy 1997;4(2):120-7.
1997: Ryuichi Morishita; Motokuni Aoki; Shun Nakamura; H Matsushita; Naruya Tomita; Seiji Hayashi; Atsushi Moriguchi; Kunihiro Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
Potential role of a novel vascular modulator, hepatocyte growth factor (HGF), in cardiovascular disease: characterization and regulation of local HGF system.
Journal of atherosclerosis and thrombosis 1997;4(1):12-9.
1997: Motokuni Aoki; Ryuichi Morishita; H Matsushita; N Nakano; S Hayashi; Naruya Tomita; K Yamamoto; Atsushi Moriguchi; Jitsuo Higaki; Toshio Ogihara
Serum deprivation-induced apoptosis accompanied by up-regulation of p53 and bax in human aortic vascular smooth muscle cells.
Heart and vessels 1997;Suppl 12():71-5.
1997: Ryuichi Morishita; Shun Nakamura; Y Nakamura; Motokuni Aoki; Atsushi Moriguchi; Iwao Kida; Yoshikage Yo; Kunihiro Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
Potential role of an endothelium-specific growth factor, hepatocyte growth factor, on endothelial damage in diabetes.
Diabetes 1997;46(1):138-42.
1996: K Yamada; Atsushi Moriguchi; Ryuichi Morishita; Motokuni Aoki; Y Nakamura; Hiroshi Mikami; T Oshima; M Ninomiya; Yasufumi Kaneda; Jitsuo Higaki; Toshio Ogihara
Efficient oligonucleotide delivery using the HVJ-liposome method in the central nervous system.
The American journal of physiology 1996;271(5 Pt 2):R1212-20.
1996: Seiji Hayashi; Ryuichi Morishita; Motokuni Aoki; Atsushi Moriguchi; Iwao Kida; M Nakajima; Yasufumi Kaneda; Jitsuo Higaki; Toshio Ogihara
In vivo transfer of gene and oligodeoxynucleotides into skin of fetal rats by incubation in amniotic fluid.
Gene therapy 1996;3(10):878-85.
1996: Y Nakamura; Ryuichi Morishita; Jitsuo Higaki; Iwao Kida; Motokuni Aoki; Atsushi Moriguchi; K Yamada; Seiji Hayashi; Yoshikage Yo; H Nakano; K Matsumoto; Tadashi Nakamura; Toshio Ogihara
Hepatocyte growth factor is a novel member of the endothelium-specific growth factors: additive stimulatory effect of hepatocyte growth factor with basic fibroblast growth factor but not with vascular endothelial growth factor.
Journal of hypertension 1996;14(9):1067-72.
1996: Ryuichi Morishita; Toshio Ogihara
[Application of decoy strategy].
Nihon rinsho. Japanese journal of clinical medicine 1996;54(9):2583-90.
1996: Y Nakamura; Ryuichi Morishita; Shun Nakamura; Motokuni Aoki; Atsushi Moriguchi; K Matsumoto; Tadashi Nakamura; Jitsuo Higaki; Toshio Ogihara
A vascular modulator, hepatocyte growth factor, is associated with systolic pressure.
Hypertension 1996;28(3):409-13.
1996: N Tomita; Ryuichi Morishita; Jitsuo Higaki; S Tomita; Motokuni Aoki; Yasufumi Kaneda; Toshio Ogihara
Sustained transgene expression by transfection of renin gene into liver of neonates.
Biochemical and biophysical research communications 1996;224(1):43-9.
1996: N Tomita; Ryuichi Morishita; Jitsuo Higaki; S Tomita; Motokuni Aoki; Toshio Ogihara; Yasufumi Kaneda
In vivo gene transfer of insulin gene into neonatal rats by the HVJ-liposome method resulted in sustained transgene expression.
Gene therapy 1996;3(6):477-82.
1996: Seiji Hayashi; Ryuichi Morishita; Jitsuo Higaki; Motokuni Aoki; Atsushi Moriguchi; Iwao Kida; S Yoshiki; K Matsumoto; Tadashi Nakamura; Yasufumi Kaneda; Toshio Ogihara
Autocrine-paracrine effects of overexpression of hepatocyte growth factor gene on growth of endothelial cells.
Biochemical and biophysical research communications 1996;220(3):539-45.
1996: Ryuichi Morishita; Jitsuo Higaki; N Tomita; Motokuni Aoki; Atsushi Moriguchi; K Tamura; K Murakami; Yasufumi Kaneda; Toshio Ogihara
Role of transcriptional cis-elements, angiotensinogen gene-activating elements, of angiotensinogen gene in blood pressure regulation.
Hypertension 1996;27(3 Pt 2):502-7.
1996: Ryuichi Morishita; Jitsuo Higaki; M Aoki; S Hayashi; Iwao Kida; Yasufumi Kaneda; Toshio Ogihara
Novel strategy of gene therapy in cardiovascular disease with HVJ-liposome method.
Contributions to nephrology 1996;118():254-64.
1995: N Tomita; Ryuichi Morishita; Jitsuo Higaki; S Tomita; Motokuni Aoki; Yasufumi Kaneda; Toshio Ogihara
Effect of angiotensinogen on blood pressure regulation in normotensive rats: application of a loss of function approach.
Journal of hypertension 1995;13(12 Pt 2):1767-74.
1995: Shuntaro Hara; Ryuichi Morishita; Yoshinori Tone; Chieko Yokoyama; H Inoue; Yasufumi Kaneda; Toshio Ogihara; Tadashi Tanabe
Overexpression of prostacyclin synthase inhibits growth of vascular smooth muscle cells.
Biochemical and biophysical research communications 1995;216(3):862-7.
1995: Yoshiki Sawa; K Suzuki; HZ Bai; Ryota Shirakura; Ryuichi Morishita; Yasufumi Kaneda; H Matsuda
Efficiency of in vivo gene transfection into transplanted rat heart by coronary infusion of HVJ liposome.
Circulation 1995;92(9 Suppl):II479-82.
1995: Y Nakamura; Ryuichi Morishita; Jitsuo Higaki; Iwao Kida; Motokuni Aoki; Atsushi Moriguchi; K Yamada; Seiji Hayashi; Yoshikage Yo; K Matsumoto
Expression of local hepatocyte growth factor system in vascular tissues.
Biochemical and biophysical research communications 1995;215(2):483-8.
1995: Ryuichi Morishita; Jitsuo Higaki; Y Nakamura; M Aoki; K Yamada; Atsushi Moriguchi; Hiromi Rakugi; N Tomita; S Tomita; H Yu
Effect of an antihypertensive drug on brain angiotensin II levels in renal and spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology 1995;22(9):665-9.
1995: Yasufumi Kaneda; Ryuichi Morishita; N Tomita
Increased expression of DNA cointroduced with nuclear protein in adult rat liver.
Journal of molecular medicine (Berlin, Germany) 1995;73(6):289-97.
1994: K Katahira; Hiroshi Mikami; A Otsuka; Atsushi Moriguchi; K Kohara; K Higashimori; N Okuda; M Nagano; Ryuichi Morishita; Toshio Ogihara
Differential control of vascular tone and heart rate by different amino acid neurotransmitters in the rostral ventrolateral medulla of the rat.
Clinical and experimental pharmacology & physiology 1994;21(7):545-56.
1993: H Yu; Hiromi Rakugi; Jitsuo Higaki; Ryuichi Morishita; Hiroshi Mikami; Toshio Ogihara
The role of activated vascular angiotensin II generation in vascular hypertrophy in one-kidney, one clip hypertensive rats.
Journal of hypertension 1993;11(12):1347-55.
1993: N Tomita; Jitsuo Higaki; Yasufumi Kaneda; H Yu; Ryuichi Morishita; Hiroshi Mikami; Toshio Ogihara
Hypertensive rats produced by in vivo introduction of the human renin gene.
Circulation research 1993;73(5):898-905.
1993: F Nakamura; M Nagano; Jitsuo Higaki; K Higashimori; Ryuichi Morishita; Hiroshi Mikami; Toshio Ogihara
The angiotensin-converting enzyme inhibitor, perindopril, prevents cardiac hypertrophy in low-renin hypertensive rats.
Clinical and experimental pharmacology & physiology 1993;20(3):135-40.
1993: Ryuichi Morishita; Jitsuo Higaki; H Okunishi; F Nakamura; M Nagano; Hiroshi Mikami; K Ishii; M Miyazaki; Toshio Ogihara
Role of tissue renin angiotensin system in two-kidney, one-clip hypertensive rats.
The American journal of physiology 1993;264(3 Pt 2):F510-4.
1993: Ryuichi Morishita; Jitsuo Higaki; M Nagano; F Nakamura; N Tomita; Y Zhao; Hiroshi Mikami; M Miyazaki; Toshio Ogihara
Discrepancy between renin mRNA and plasma renin level in angiotensin-converting enzyme inhibitor-treated rats.
Clinical and experimental pharmacology & physiology 1993;20(1):15-20.
1992: N Tomita; Jitsuo Higaki; Ryuichi Morishita; K Kato; Hiroshi Mikami; Yasufumi Kaneda; Toshio Ogihara
Direct in vivo gene introduction into rat kidney.
Biochemical and biophysical research communications 1992;186(1):129-34.
1992: Ryuichi Morishita; Jitsuo Higaki; M Miyazaki; Toshio Ogihara
Possible role of the vascular renin-angiotensin system in hypertension and vascular hypertrophy.
Hypertension 1992;19(2 Suppl):II62-7.
1992: Ryuichi Morishita; Jitsuo Higaki; Hiroshi Mikami; N Matsukawa; Toshio Ogihara
Effect of aging on the renin angiotensin system in patients with renovascular hypertension.
Methods and findings in experimental and clinical pharmacology 1992;14(1):17-21.
1992: Ryuichi Morishita; Jitsuo Higaki; F Nakamura; N Tomita; H Yu; M Nagano; Hiroshi Mikami; Toshio Ogihara
Regression of hypertension-induced vascular hypertrophy by an ACE inhibitor and calcium antagonist in the spontaneously hypertensive rat.
Blood pressure. Supplement 1992;3():41-7.
1991: F Nakamura; M Nagano; Jitsuo Higaki; K Higashimori; K Katahira; Ryuichi Morishita; Hiroshi Mikami; Toshio Ogihara
Regression of left ventricular hypertrophy by angiotensin converting enzyme inhibitor in reduced renal mass hypertensive rats.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1991;9(6):S398-9.
1991: Tomohiro Katsuya; J Higaki; T Miki; J Nakura; H Ikegami; Ryuichi Morishita; M Nagano; K Higashimori; F Nakamura; H Mikami
Substrain comparison of genetically hypertensive rats using DNA fingerprinting, and genetic analysis of blood pressure in the inbred rats.
The Tohoku journal of experimental medicine 1991;165(4):253-60.
1991: Jitsuo Higaki; A Miya; T Miki; Ryuichi Morishita; Hiroshi Mikami; Shin-ichiro Takai; Toshio Ogihara
Contribution of the activation of the ras oncogene to the evolution of aldosterone- and renin-secreting tumors.
Journal of hypertension 1991;9(2):135-7.
1990: Ryuichi Morishita; Jitsuo Higaki; Hiroshi Mikami; Toshio Ogihara
Effect of cyclosporin A on aldosterone production by dispersed rabbit adreno-capsular cells.
Life sciences 1990;46(26):1985-9.
1989: Jitsuo Higaki; M Okuno; M Nakamaru; Ryuichi Morishita; S Himeno; Toshio Ogihara
Changes in plasma active renin and prorenin after endoscopic retrograde pancreatography.
Methods and findings in experimental and clinical pharmacology 1989;11(11):703-5.
1989: Ryuichi Morishita; Jitsuo Higaki; Toshio Ogihara
Endothelin stimulates aldosterone biosynthesis by dispersed rabbit adreno-capsular cells.
Biochemical and biophysical research communications 1989;160(2):628-32.
1989: Jitsuo Higaki; Ryuichi Morishita; Toshio Ogihara
Measurements of enzyme activity and immunoreactivity of plasma renin. Limitations of the conventional method for assay of plasma renin catalytic activity.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift für klinische Chemie und klinische Biochemie 1989;27(4):201-4.