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Lorena Beese

Research Profile

Procedures

X Ray Crystallography

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Chemicals & Drugs

Phenomena

Protein Binding

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

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Geobacillus stearothermophilus

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Publications

TOP 3
Weina Wang; Eugene Y Wu; Homme W Hellinga; Lorena S Beese
Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
Santoshkumar L Khatwani; Daniel G Mullen; Lorena S Beese; Mark D Distefano; Michael A Hast; Jun Sung Kang; T Andrew Taton
Covalent protein-oligonucleotide conjugates by copper-free click reaction.
Weina Wang; Homme W Hellinga; Lorena S Beese
Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.

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All Publications

2012: Weina Wang; Eugene Y Wu; Homme W Hellinga; Lorena S Beese
Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.
The Journal of biological chemistry 2012;287(34):28215-26.
2012: Santoshkumar L Khatwani; Daniel G Mullen; Lorena S Beese; Mark D Distefano; Michael A Hast; Jun Sung Kang; T Andrew Taton
Covalent protein-oligonucleotide conjugates by copper-free click reaction.
Bioorganic & medicinal chemistry 2012;20(14):4532-9.
2011: Weina Wang; Homme W Hellinga; Lorena S Beese
Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(43):17644-8.
2011: Michael A Hast; Homme W Hellinga; Shannon M Kelly; Connie B Nichols; J Andrew Alspaugh; Stephanie M Armstrong; Lorena S Beese
Structures of Cryptococcus neoformans protein farnesyltransferase reveal strategies for developing inhibitors that target fungal pathogens.
The Journal of biological chemistry 2011;286(40):35149-62.
2011: Quincy Tseng; Anita Changela; Michael A Hast; Ravi R Iyer; Paul Modrich; Jillian Orans; Lorena S Beese
Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 8):947-52.
2011: Eugene Y Wu; Lorena S Beese
The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism.
The Journal of biological chemistry 2011;286(22):19758-67.
2011: Jillian Orans; Elizabeth A McSweeney; Ravi R Iyer; Michael A Hast; Homme W Hellinga; Paul Modrich; Lorena S Beese
Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell 2011;145(2):212-23.
2010: Stephen Fletcher; Erin Pusateri Keaney; Christopher G Cummings; Michelle A Blaskovich; Michael A Hast; Matthew Glenn; Sung-Youn Chang; Cynthia J Bucher; Ryan J Floyd; William P Katt; Michael H Gelb; Wesley C Van Voorhis; Lorena S Beese; Said M Sebti; Andrew D Hamilton
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
Journal of medicinal chemistry 2010;53(19):6867-88.
2010: Ravi R Iyer; Anna Pluciennik; Jochen Genschel; Miaw-Sheue Tsai; Lorena S Beese; Paul Modrich
MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta.
The Journal of biological chemistry 2010;285(15):11730-9.
2010: Andrei A Golosov; Joshua J Warren; Lorena S Beese; Martin Karplus
The mechanism of the translocation step in DNA replication by DNA polymerase I: a computer simulation analysis.
Structure (London, England : 1993) 2010;18(1):83-93.
2009: Matthew J Cuneo; Lorena S Beese; Homme W Hellinga
Structural analysis of semi-specific oligosaccharide recognition by a cellulose-binding protein of thermotoga maritima reveals adaptations for functional diversification of the oligopeptide periplasmic binding protein fold.
The Journal of biological chemistry 2009;284(48):33217-23.
2009: Michael Trostler; Alison Delier; Jeff Beckman; Milan Urban; Jennifer N Patro; Thomas E Spratt; Lorena S Beese; Robert D Kuchta
Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus.
Biochemistry 2009;48(21):4633-41.
2009: Matthew J Cuneo; Anita Changela; Lorena S Beese; Homme W Hellinga
Structural adaptations that modulate monosaccharide, disaccharide, and trisaccharide specificities in periplasmic maltose-binding proteins.
Journal of molecular biology 2009;389(1):157-66.
2009: Michael A Hast; Stephen Fletcher; Christopher G Cummings; Erin E Pusateri; Michelle A Blaskovich; Kasey Rivas; Michael H Gelb; Wesley C Van Voorhis; Said M Sebti; Andrew D Hamilton; Lorena S Beese
Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.
Chemistry & biology 2009;16(2):181-92.
2008: Matthew J Cuneo; Anita Changela; Aleksandr E Miklos; Lorena S Beese; Joanna K Krueger; Homme W Hellinga
Structural analysis of a periplasmic binding protein in the tripartite ATP-independent transporter family reveals a tetrameric assembly that may have a role in ligand transport.
The Journal of biological chemistry 2008;283(47):32812-20.
2008: Michael A Hast; Lorena S Beese
Structure of protein geranylgeranyltransferase-I from the human pathogen Candida albicans complexed with a lipid substrate.
The Journal of biological chemistry 2008;283(46):31933-40.
2008: Amanda DeGraw; Michael A Hast; Juhua Xu; Daniel Mullen; Lorena S Beese; George Barany; Mark D Distefano
Caged protein prenyltransferase substrates: tools for understanding protein prenylation.
Chemical biology & drug design 2008;72(3):171-81.
2008: Ravi R Iyer; Timothy J Pohlhaus; Sihong Chen; Gregory L Hura; Leonid Dzantiev; Lorena S Beese; Paul Modrich
The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair.
The Journal of biological chemistry 2008;283(19):13310-9.
2008: Matthew J Cuneo; Lorena S Beese; Homme W Hellinga
Ligand-induced conformational changes in a thermophilic ribose-binding protein.
BMC structural biology 2008;8():50.
2008: Florian Büsch; J Carsten Pieck; Matthias Ober; Johannes Gierlich; Gerald W Hsu; Lorena S Beese; Thomas Carell
Dissecting the differences between the alpha and beta anomers of the oxidative DNA lesion FaPydG.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(7):2125-32.
2007: Yaji Tian; Matthew J Cuneo; Anita Changela; Birte Höcker; Lorena S Beese; Homme W Hellinga
Structure-based design of robust glucose biosensors using a Thermotoga maritima periplasmic glucose-binding protein.
Protein science : a publication of the Protein Society 2007;16(10):2240-50.
2007: Joshua J Warren; Timothy J Pohlhaus; Anita Changela; Ravi R Iyer; Paul Modrich; Lorena S Beese
Structure of the human MutSalpha DNA lesion recognition complex.
Molecular cell 2007;26(4):579-92.
2007: Richard Eastman; John White; Oliver Hucke; Kohei Yokoyama; Christophe Verlinde; Michael A Hast; Lorena S Beese; Michael H Gelb; Pradipsinh K Rathod; Wesley C Van Voorhis
Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.
Molecular and biochemical parasitology 2007;152(1):66-71.
2007: Pingna Xu; Lida Oum; Lorena S Beese; Nicholas E Geacintov; Suse Broyde
Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase.
Nucleic acids research 2007;35(13):4275-88.
2006: Joshua J Warren; Lawrence J Forsberg; Lorena S Beese
The structural basis for the mutagenicity of O(6)-methyl-guanine lesions.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19701-6.
2006: Matthew J Cuneo; Anita Changela; Joshua J Warren; Lorena S Beese; Homme W Hellinga
The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites.
Journal of molecular biology 2006;362(2):259-70.
2006: Kimberly L Terry; Patrick J Casey; Lorena S Beese
Conversion of protein farnesyltransferase to a geranylgeranyltransferase.
Biochemistry 2006;45(32):9746-55.
2006: Kimberly T Lane; Lorena S Beese
Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I.
Journal of lipid research 2006;47(4):681-99.
2005: Gerald W Hsu; Xuanwei Huang; Natalia P Luneva; Nicholas E Geacintov; Lorena S Beese
Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication.
The Journal of biological chemistry 2005;280(5):3764-70.
2004: Gerald W Hsu; James R Kiefer; Dominique Burnouf; Olivier J Becherel; Robert Fuchs; Lorena S Beese
Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase.
The Journal of biological chemistry 2004;279(48):50280-5.
2004: T Scott Reid; Kimberly L Terry; Patrick J Casey; Lorena S Beese
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
Journal of molecular biology 2004;343(2):417-33.
2004: Gerald W Hsu; Matthias Ober; Thomas Carell; Lorena S Beese
Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase.
Nature 2004;431(7005):217-21.
2004: T Scott Reid; Stephen Barstow Long; Lorena S Beese
Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes.
Biochemistry 2004;43(28):9000-8.
2004: T Scott Reid; Lorena S Beese
Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity.
Biochemistry 2004;43(22):6877-84.
2004: Sean J Johnson; Lorena S Beese
Structures of mismatch replication errors observed in a DNA polymerase.
Cell 2004;116(6):803-16.
2003: Jeffrey S Taylor; T Scott Reid; Kimberly L Terry; Patrick J Casey; Lorena S Beese
Structure of mammalian protein geranylgeranyltransferase type-I.
The EMBO journal 2003;22(22):5963-74.
2003: S Jane deSolms; Terrence M Ciccarone; Suzanne C MacTough; Anthony W Shaw; Carolyn A Buser; Michelle Ellis-Hutchings; Christine Fernandes; Kelly A Hamilton; Hans E Huber; Nancy E Kohl; Robert B Lobell; Ronald G Robinson; Nancy N Tsou; Eileen S Walsh; Samuel L Graham; Lorena S Beese; Jeffrey S Taylor
Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.
Journal of medicinal chemistry 2003;46(14):2973-84.
2003: Sean J Johnson; Jeffrey S Taylor; Lorena S Beese
Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):3895-900.
2002: Stephen Barstow Long; Patrick J Casey; Lorena S Beese
Reaction path of protein farnesyltransferase at atomic resolution.
Nature 2002;419(6907):645-50.
2001: Stephen Barstow Long; P J Hancock; A M Kral; Homme W Hellinga; Lorena S Beese
The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):12948-53.
2000: R A Spence; KE Hightower; Kimberly L Terry; Lorena S Beese; Carol A Fierke; Patrick J Casey
Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition.
Biochemistry 2000;39(45):13651-9.
2000: A C Rodriguez; H W Park; C Mao; Lorena S Beese
Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7.
Journal of molecular biology 2000;299(2):447-62.
2000: Stephen Barstow Long; Patrick J Casey; Lorena S Beese
The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
Structure (London, England : 1993) 2000;8(2):209-22.
1998: M Zhou; C Mao; A C Rodriguez; James R Kiefer; R B Kucera; Lorena S Beese
Crystallization and preliminary diffraction analysis of a hyperthermostable DNA polymerase from a Thermococcus archaeon.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 5):994-5.
1998: Stephen Barstow Long; Patrick J Casey; Lorena S Beese
Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.
Biochemistry 1998;37(27):9612-8.
1998: Hua-Wen Fu; Lorena S Beese; Patrick J Casey
Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase.
Biochemistry 1998;37(13):4465-72.
1998: James R Kiefer; C Mao; Jeffrey Carl Braman; Lorena S Beese
Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal.
Nature 1998;391(6664):304-7.
1997: H W Park; Lorena S Beese
Protein farnesyltransferase.
Current opinion in structural biology 1997;7(6):873-80.
1997: H W Park; S R Boduluri; J F Moomaw; Patrick J Casey; Lorena S Beese
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution.
Science (New York, N.Y.) 1997;275(5307):1800-4.
1997: James R Kiefer; C Mao; Connie J Hansen; S L Basehore; Holly H Hogrefe; Jeffrey Carl Braman; Lorena S Beese
Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution.
Structure (London, England : 1993) 1997;5(1):95-108.
1989: M K Lamvik; P Ingram; R G Menon; Lorena S Beese; S D Davilla; A LeFurgey
Correction for specimen movement after acquisition of element-specific electron microprobe images.
Journal of microscopy 1989;156(Pt 2):183-90.