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Uwe Beffert

Research Profile

Chemicals & Drugs

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Alzheimer's Disease

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Publications

TOP 3
Uwe Beffert; Gregory M Dillon; James P Gilbert; John A Kambouris; Christine E Stuart; Josefa M Sullivan; Angela Ho
Microtubule plus-end tracking protein CLASP2 regulates neuronal polarity and synaptic function.
Alin L Akopians; Alex H Babayan; Uwe Beffert; Joachim Herz; Allan I Basbaum; Patricia E Phelps
Contribution of the Reelin signaling pathways to nociceptive processing.
Matt Larouche; Uwe Beffert; Joachim Herz; Richard Hawkes
The Reelin receptors Apoer2 and Vldlr coordinate the patterning of Purkinje cell topography in the developing mouse cerebellum.

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All Publications

2012: Uwe Beffert; Gregory M Dillon; James P Gilbert; John A Kambouris; Christine E Stuart; Josefa M Sullivan; Angela Ho
Microtubule plus-end tracking protein CLASP2 regulates neuronal polarity and synaptic function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(40):13906-16.
2008: Alin L Akopians; Alex H Babayan; Uwe Beffert; Joachim Herz; Allan I Basbaum; Patricia E Phelps
Contribution of the Reelin signaling pathways to nociceptive processing.
The European journal of neuroscience 2008;27(3):523-37.
2008: Matt Larouche; Uwe Beffert; Joachim Herz; Richard Hawkes
The Reelin receptors Apoer2 and Vldlr coordinate the patterning of Purkinje cell topography in the developing mouse cerebellum.
PloS one 2008;3(2):e1653.
2007: Guangcheng Zhang; Amir H Assadi; Robert S McNeil; Uwe Beffert; Anthony Wynshaw-Boris; Joachim Herz; Gary D Clark; Gabriella D'Arcangelo
The Pafah1b complex interacts with the reelin receptor VLDLR.
PloS one 2007;2(2):e252.
2006: Uwe Beffert; Farnas Nematollah Farsian; Irene Masiulis; Robert E Hammer; Sung Ok Yoon; Klaus M Giehl; Joachim Herz
ApoE receptor 2 controls neuronal survival in the adult brain.
Current biology : CB 2006;16(24):2446-52.
2006: Uwe Beffert; Roger Rosenberg
Increased risk for heterozygotes in recessive Parkinson disease.
Archives of neurology 2006;63(6):807-8.
2006: Uwe Beffert; Andre Durudas; Edwin J Weeber; Peggy C Stolt; Klaus M Giehl; J David Sweatt; Robert E Hammer; Joachim Herz
Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(7):2041-52.
2005: Hyang-Sook Hoe; David Wessner; Uwe Beffert; Amanda Becker; Yasuji Matsuoka; G. William Rebeck
F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein.
Molecular and cellular biology 2005;25(21):9259-68.
2005: Ying Chen; Uwe Beffert; Mert Ertunc; Tie-Shan Tang; Ege T Kavalali; Ilya Bezprozvanny; Joachim Herz
Reelin modulates NMDA receptor activity in cortical neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(36):8209-16.
2005: Uwe Beffert; Edwin J Weeber; Andre Durudas; Shenfeng Qiu; Irene Masiulis; J David Sweatt; Wei-Ping Li; Giselind Adelmann; Michael Frotscher; Robert E Hammer; Joachim Herz
Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2.
Neuron 2005;47(4):567-79.
2005: Caroline Petit-Turcotte; Nicole Aumont; Uwe Beffert; Doris Dea; Joachim Herz; Judes Poirier
The apoE receptor apoER2 is involved in the maintenance of efficient synaptic plasticity.
Neurobiology of aging 2005;26(2):195-206.
2004: Petra May; Astrid Rohlmann; Hans H Bock; Kai Zurhove; Jamey D Marth; Eike D Schomburg; Jeffrey L Noebels; Uwe Beffert; J David Sweatt; Edwin J Weeber; Joachim Herz
Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice.
Molecular and cellular biology 2004;24(20):8872-83.
2004: Gerardo Morfini; Györgyi Szebenyi; Hannah Brown; Varsha Shukla; Gustavo Pigino; Scott DeBoer; Uwe Beffert; Scott T Brady
A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons.
The EMBO journal 2004;23(11):2235-45.
2004: Uwe Beffert; Peggy C Stolt; Joachim Herz
Functions of lipoprotein receptors in neurons.
Journal of lipid research 2004;45(3):403-9.
2004: Uwe Beffert; Edwin J Weeber; Gerardo Morfini; Jane Ko; Scott T Brady; Li-Huei Tsai; J David Sweatt; Joachim Herz
Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(8):1897-906.
2003: Amir H Assadi; Guangcheng Zhang; Uwe Beffert; Robert S McNeil; Amy Renfro; Sanyong Niu; Carlo C Quattrocchi; Barbara Antalffy; Michael Sheldon; Dawna Duncan Armstrong; Anthony Wynshaw-Boris; Joachim Herz; Gabriella D'Arcangelo; Gary D Clark
Interaction of reelin signaling and Lis1 in brain development.
Nature genetics 2003;35(3):270-6.
2002: Uwe Beffert; Gerardo Morfini; Hans H Bock; Huichuan Reyna; Scott T Brady; Joachim Herz
Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta.
The Journal of biological chemistry 2002;277(51):49958-64.
2002: Edwin J Weeber; Uwe Beffert; Chris Jones; Jill M Christian; Eckart Forster; J David Sweatt; Joachim Herz
Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning.
The Journal of biological chemistry 2002;277(42):39944-52.
2002: Gerardo Morfini; Gustavo Pigino; Uwe Beffert; Jorge Busciglio; Scott T Brady
Fast axonal transport misregulation and Alzheimer's disease.
Neuromolecular medicine 2002;2(2):89-99.
2001: Caroline Petit-Turcotte; S M Stohl; Uwe Beffert; Jeffrey S Cohn; Nicole Aumont; M Tremblay; Doris Dea; L Yang; Judes Poirier; Neil S Shachter
Apolipoprotein C-I expression in the brain in Alzheimer's disease.
Neurobiology of disease 2001;8(6):953-63.
2000: Joachim Herz; Uwe Beffert
Apolipoprotein E receptors: linking brain development and Alzheimer's disease.
Nature reviews. Neuroscience 2000;1(1):51-8.
2000: Charles Ramassamy; D Averill; Uwe Beffert; L Theroux; Suzanne Lussier-Cacan; Jeffrey S Cohn; Yves Christen; A Schoofs; J Davignon; Judes Poirier
Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain.
Neurobiology of disease 2000;7(1):23-37.
1999: Uwe Beffert; Jeffrey S Cohn; Caroline Petit-Turcotte; M Tremblay; Nicole Aumont; Charles Ramassamy; J Davignon; Judes Poirier
Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent.
Brain research 1999;843(1-2):87-94.
1999: Charles Ramassamy; D Averill; Uwe Beffert; Stéphane Bastianetto; L Theroux; Suzanne Lussier-Cacan; Jeffrey S Cohn; Yves Christen; J Davignon; Rémi Quirion; Judes Poirier
Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype.
Free radical biology & medicine 1999;27(5-6):544-53.
1999: Uwe Beffert; Nicole Aumont; Doris Dea; Suzanne Lussier-Cacan; J Davignon; Judes Poirier
Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures.
Brain research. Molecular brain research 1999;68(1-2):181-5.
1999: Uwe Beffert; Chantal Arguin; Judes Poirier
The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease.
Neuroscience letters 1999;259(1):29-32.
1999: Marc Danik; D Champagne; Caroline Petit-Turcotte; Uwe Beffert; Judes Poirier
Brain lipoprotein metabolism and its relation to neurodegenerative disease.
Critical reviews in neurobiology 1999;13(4):357-407.
1998: Uwe Beffert; Judes Poirier
ApoE associated with lipid has a reduced capacity to inhibit beta-amyloid fibril formation.
Neuroreport 1998;9(14):3321-3.
1998: Uwe Beffert; Marc Danik; Pascale Krzywkowski; Charles Ramassamy; F Berrada; Judes Poirier
The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease.
Brain research. Brain research reviews 1998;27(2):119-42.
1998: Uwe Beffert; P Bertrand; D Champagne; S Gauthier; J Poirier
HSV-1 in brain and risk of Alzheimer's disease.
Lancet 1998;351(9112):1330-1.
1998: Uwe Beffert; Nicole Aumont; Doris Dea; Suzanne Lussier-Cacan; J Davignon; Judes Poirier
Beta-amyloid peptides increase the binding and internalization of apolipoprotein E to hippocampal neurons.
Journal of neurochemistry 1998;70(4):1458-66.
1996: Uwe Beffert; Judes Poirier
Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease.
Annals of the New York Academy of Sciences 1996;777():166-74.
1995: Judes Poirier; Uwe Beffert; Doris Dea; R Alonso; D O'Donnell; Patricia Boksa
Increased levels of statin, a marker of cell cycle arrest, in response to hippocampal neuronal injury.
Brain research. Molecular brain research 1995;34(1):57-64.