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Ken-ichirou Morohashi
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8
Mizusaki, Hirofumi
8
Zubair, Mohamad
6
Oka, Sanae
6
Katoh-Fukui, Yuko
5
Kawabe, Ken
5
Hatano, Osamu
5
Mukai, Tokuo
5
Nawata, Hajime
4
Umesono, Kazuhiko
4
Kasahara, Megumi
4
Ishihara, Satoru
3
Kawabata, Shun-ichiro
3
Yoshioka, Hidefumi
3
Nonaka, Yasuki
3
Suzuki, Taiga
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All Publications
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2009: Ogawa Hidesato; Komatsu Tomoko; Hiraoka Yasushi; Morohashi Ken-Ichirou
Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated nuclear receptor Ad4BP/SF-1.
Molecular biology of the cell 2009;20(19):4235-45.
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2009: Zubair Mohamad; Oka Sanae; Parker Keith L; Morohashi Ken-Ichirou
Transgenic expression of Ad4BP/SF-1 in fetal adrenal progenitor cells leads to ectopic adrenal formation.
Molecular endocrinology (Baltimore, Md.) 2009;23(10):1657-67.
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2009: Yokoyama Chikako; Komatsu Tomoko; Ogawa Hidesato; Morohashi Ken-ichirou; Azuma Masayuki; Tachibana Taro
Generation of rat monoclonal antibodies specific for Ad4BP/SF-1.
Hybridoma (2005) 2009;28(2):113-9.
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2009: Hiramatsu Ryuji; Matoba Shogo; Kanai-Azuma Masami; Tsunekawa Naoki; Katoh-Fukui Yuko; Kurohmaru Masamichi; Morohashi Ken-Ichirou; Wilhelm Dagmar; Koopman Peter; Kanai Yoshiakira
A critical time window of Sry action in gonadal sex determination in mice.
Development (Cambridge, England) 2009;136(1):129-38.
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2008: Zubair Mohamad; Parker Keith L; Morohashi Ken-ichirou
Developmental links between the fetal and adult zones of the adrenal cortex revealed by lineage tracing.
Molecular and cellular biology 2008;28(23):7030-40.
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2008: Sakai Noriko; Terami Hiromi; Suzuki Shinobu; Haga Megumi; Nomoto Ken; Tsuchida Nobuko; Morohashi Ken-ichirou; Saito Naoaki; Asada Maki; Hashimoto Megumi; Harada Daisuke; Asahara Hiroshi; Ishikawa Tetsuya; Shimada Fumiki; Sakurada Kazuhiro
Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies.
The Journal of endocrinology 2008;198(3):489-97.
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2008: Sato Yuko; Baba Takashi; Zubair Mohamad; Miyabayashi Kanako; Toyama Yoshiro; Maekawa Mamiko; Owaki Akiko; Mizusaki Hirofumi; Sawamura Tatsuya; Toshimori Kiyotaka; Morohashi Ken-Ichirou; Katoh-Fukui Yuko
Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature.
Molecular reproduction and development 2008;75(9):1361-71.
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2008: Shima Yuichi; Zubair Mohamad; Komatsu Tomoko; Oka Sanae; Yokoyama Chikako; Tachibana Taro; Hjalt Tord A; Drouin Jacques; Morohashi Ken-ichirou
Pituitary homeobox 2 regulates adrenal4 binding protein/steroidogenic factor-1 gene transcription in the pituitary gonadotrope through interaction with the intronic enhancer.
Molecular endocrinology (Baltimore, Md.) 2008;22(7):1633-46.
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2008: Fukami Maki; Wada Yuka; Okada Michiyo; Kato Fumiko; Katsumata Noriyuki; Baba Takashi; Morohashi Ken-ichirou; Laporte Jocelyn; Kitagawa Motoo; Ogata Tsutomu
Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence.
The Journal of biological chemistry 2008;283(9):5525-32.
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2008: Baba T; Shima Y; Owaki A; Mimura J; Oshima M; Fujii-Kuriyama Y; Morohashi K-i
Disruption of aryl hydrocarbon receptor (AhR) induces regression of the seminal vesicle in aged male mice.
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2008;2(1):1-11.
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2007: Kurokawa Hiromi; Saito Daisuke; Nakamura Shuhei; Katoh-Fukui Yuko; Ohta Kohei; Baba Takashi; Morohashi Ken-ichiro; Tanaka Minoru
Germ cells are essential for sexual dimorphism in the medaka gonad.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):16958-63.
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2006: Zubair Mohamad; Ishihara Satoru; Oka Sanae; Okumura Katsuzumi; Morohashi Ken-ichirou
Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1.
Molecular and cellular biology 2006;26(11):4111-21.
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2006: Fatchiyah; Zubair Mohamad; Shima Yuichi; Oka Sanae; Ishihara Satoru; Fukui-Katoh Yuko; Morohashi Ken-ichirou
Differential gene dosage effects of Ad4BP/SF-1 on target tissue development.
Biochemical and biophysical research communications 2006;341(4):1036-45.
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2005: Baba Takashi; Mimura Junsei; Nakamura Naohito; Harada Nobuhiro; Yamamoto Masayuki; Morohashi Ken-Ichirou; Fujii-Kuriyama Yoshiaki
Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction.
Molecular and cellular biology 2005;25(22):10040-51.
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2005: Shima Yuichi; Zubair Mohamad; Ishihara Satoru; Shinohara Yuko; Oka Sanae; Kimura Shioko; Okamoto Shiki; Minokoshi Yasuhiko; Suita Sachiyo; Morohashi Ken-ichirou
Ventromedial hypothalamic nucleus-specific enhancer of Ad4BP/SF-1 gene.
Molecular endocrinology (Baltimore, Md.) 2005;19(11):2812-23.
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2005: Katoh-Fukui Yuko; Owaki Akiko; Toyama Yoshiro; Kusaka Masatomo; Shinohara Yuko; Maekawa Mamiko; Toshimori Kiyotaka; Morohashi Ken-Ichirou
Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression.
Blood 2005;106(5):1612-20.
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2005: Matsuyama Makoto; Mizusaki Hirofumi; Shimono Akihiko; Mukai Tokuo; Okumura Katsuzumi; Abe Kuniya; Shimada Kiyoshi; Morohashi Ken-ichirou
A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(5):421-34.
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2005: Ishihara Satoru L; Morohashi Ken-ichirou
A boundary for histone acetylation allows distinct expression patterns of the Ad4BP/SF-1 and GCNF loci in adrenal cortex cells.
Biochemical and biophysical research communications 2005;329(2):554-62.
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2004: Komatsu Tomoko; Mizusaki Hirofumi; Mukai Tokuo; Ogawa Hidesato; Baba Daichi; Shirakawa Masahiro; Hatakeyama Shigetsugu; Nakayama Keiichi I; Yamamoto Hideki; Kikuchi Akira; Morohashi Ken-ichirou
Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9.
Molecular endocrinology (Baltimore, Md.) 2004;18(10):2451-62.
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2004: Ogawa Hidesato; Yu Ruth T; Haraguchi Tokuko; Hiraoka Yasushi; Nakatani Yoshihiro; Morohashi Ken-ichirou; Umesono Kazuhiko
Nuclear structure-associated TIF2 recruits glucocorticoid receptor and its target DNA.
Biochemical and biophysical research communications 2004;320(1):218-25.
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2004: Toda Katsumi; Okada Yasushi; Zubair Mohamad; Morohashi Ken-Ichiro; Saibara Toshiji; Okada Teruhiko
Aromatase-knockout mouse carrying an estrogen-inducible enhanced green fluorescent protein gene facilitates detection of estrogen actions in vivo.
Endocrinology 2004;145(4):1880-8.
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2004: Mitsunaga Kanae; Araki Kimi; Mizusaki Hirofumi; Morohashi Ken-Ichirou; Haruna Kyoko; Nakagata Naomi; Giguère Vincent; Yamamura Ken-Ichi; Abe Kuniya
Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos.
Mechanisms of development 2004;121(3):237-46.
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2004: Morohashi Ken-ichirou; Katoh-Fukui Yuko
[Sex differentiation of the mammalian gonad]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2004;49(2):130-4.
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2004: Morohashi Ken-ichirou; Mizusaki Hirofumi; Sugiyama Noriyuki; Katoh-Fukui Yuko
[Sex differentiation of the gonads and regulation of gene expression]
Nippon rinsho. Japanese journal of clinical medicine 2004;62(2):255-61.
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2003: Kawajiri Kaname; Ikuta Togo; Suzuki Taiga; Kusaka Masatomo; Muramatsu Masami; Fujieda Kenji; Tachibana Masayoshi; Morohashi Ken-Ichirou
Role of the LXXLL-motif and activation function 2 domain in subcellular localization of Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1).
Molecular endocrinology (Baltimore, Md.) 2003;17(6):994-1004.
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2003: Mizusaki Hirofumi; Kawabe Ken; Mukai Tokuo; Ariyoshi Etsuko; Kasahara Megumi; Yoshioka Hidefumi; Swain Amanda; Morohashi Ken-Ichirou
Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad.
Molecular endocrinology (Baltimore, Md.) 2003;17(4):507-19.
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2003: Suzuki Taiga; Kasahara Megumi; Yoshioka Hidefumi; Morohashi Ken-Ichirou; Umesono Kazuhiko
LXXLL-related motifs in Dax-1 have target specificity for the orphan nuclear receptors Ad4BP/SF-1 and LRH-1.
Molecular and cellular biology 2003;23(1):238-49.
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2002: Suzuki Taiga; Kasahara Megumi; Yoshioka Hidefumi; Umesono Kazuhiko; Morohashi Ken-ichirou
LXXLL motifs in Dax-1 have target specificity for the orphan nuclear receptors Ad4BP/SF-1 and LRH-1.
Endocrine research 2002;28(4):537.
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2002: Zubair Mohamad; Oka Sanae; Ishihara Satoru; Morohashi Ken-ichirou
Analysis of Ad4BP/SF-1 gene regulatory region.
Endocrine research 2002;28(4):535.
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2002: Mukai Tokuo; Kusaka Masatomo; Kawabe Ken; Goto Kiminobu; Nawata Hajime; Fujieda Kenji; Morohashi Ken-ichirou
Sexually dimorphic expression of Dax-1 in the adrenal cortex.
Genes to cells : devoted to molecular & cellular mechanisms 2002;7(7):717-29.
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2002: Suzuki Taiga; Mizusaki Hirofumi; Kawabe Ken; Kasahara Megumi; Yoshioka Hidefumi; Morohashi Ken-ichirou
Concerted regulation of gonad differentiation by transcription factors and growth factors.
Novartis Foundation symposium 2002;244():68-77; discussion 77-85, 253-7.
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2001: Ikeda Y; Takeda Y; Shikayama T; Mukai T; Hisano S; Morohashi K I
Comparative localization of Dax-1 and Ad4BP/SF-1 during development of the hypothalamic-pituitary-gonadal axis suggests their closely related and distinct functions.
Developmental dynamics : an official publication of the American Association of Anatomists 2001;220(4):363-76.
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2000: Morohashi K; Mukai T; Kawabe K; Suzuki; Mizusaki H; Ishiharal S; Umesono K; Kawajiri K
Adrenocortical and gonadal differentiation regulated by transcription factors, Ad4BP/SF-1 (NR5A1) and Dax-I (NROB1).
Endocrine research 2000;26(4):953.
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2000: Morohashi K
[Transcription factors and growth factors implicated in gonad differentiation]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(9 Suppl):1627-32.
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1999: Morohashi K
[Endocrine disrupters]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(15 Suppl):2495-500.
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1999: Morohashi K
[Response to environment and the failure leading to diseases: overview]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(15 Suppl):2493-4.
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1999: Kawabe K; Shikayama T; Tsuboi H; Oka S; Oba K; Yanase T; Nawata H; Morohashi K
Dax-1 as one of the target genes of Ad4BP/SF-1.
Molecular endocrinology (Baltimore, Md.) 1999;13(8):1267-84.
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1998: Morohashi K
[Differentiation of mammalian gonads]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1998;43(4):484-90.
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1996: Morohashi K I; Omura T
Ad4BP/SF-1, a transcription factor essential for the transcription of steroidogenic cytochrome P450 genes and for the establishment of the reproductive function.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(14):1569-77.
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1996: Oba K; Yanase T; Nomura M; Morohashi K; Takayanagi R; Nawata H
Structural characterization of human Ad4bp (SF-1) gene.
Biochemical and biophysical research communications 1996;226(1):261-7.
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1996: Ikuyama S; Ohe K; Sakai Y; Nakagaki H; Fukushima T; Kato Y; Morohashi K; Takayanagi R; Nawata H
Follicle stimulating hormone-beta subunit gene is expressed in parallel with a transcription factor Ad4BP/SF-1 in human pituitary adenomas.
Clinical endocrinology 1996;45(2):187-93.
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1996: Hatano O; Takakusu A; Nomura M; Morohashi K
Identical origin of adrenal cortex and gonad revealed by expression profiles of Ad4BP/SF-1.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(7):663-71.
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1996: Morohashi K; Nomura M
[Ad4BP/SF-1 and sex differentiation of the gonads]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1996;41(8 Suppl):1033-41.
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1996: Nomura M; Nawata H; Morohashi K
Autoregulatory loop in the regulation of the mammalian ftz-f1 gene.
The Journal of biological chemistry 1996;271(14):8243-9.
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1995: Morohashi K
[Sex differentiation and Ad4BP]
Seikagaku. The Journal of Japanese Biochemical Society 1995;67(10):1195-209.
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1995: Morohashi K; Hatano O; Nomura M; Takayama K; Hara M; Yoshii H; Takakusu A; Omura T
Function and distribution of a steroidogenic cell-specific transcription factor, Ad4BP.
The Journal of steroid biochemistry and molecular biology 1995;53(1-6):81-8.
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1995: Omura T; Morohashi K
Gene regulation of steroidogenesis.
The Journal of steroid biochemistry and molecular biology 1995;53(1-6):19-25.
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1995: Nomura M; Bärtsch S; Nawata H; Omura T; Morohashi K
An E box element is required for the expression of the ad4bp gene, a mammalian homologue of ftz-f1 gene, which is essential for adrenal and gonadal development.
The Journal of biological chemistry 1995;270(13):7453-61.
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1994: Hatano O; Takayama K; Imai T; Waterman M R; Takakusu A; Omura T; Morohashi K
Sex-dependent expression of a transcription factor, Ad4BP, regulating steroidogenic P-450 genes in the gonads during prenatal and postnatal rat development.
Development (Cambridge, England) 1994;120(10):2787-97.
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1994: Takayama K; Morohashi K; Honda S; Hara N; Omura T
Contribution of Ad4BP, a steroidogenic cell-specific transcription factor, to regulation of the human CYP11A and bovine CYP11B genes through their distal promoters.
Journal of biochemistry 1994;116(1):193-203.
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1994: Morohashi K; Iida H; Nomura M; Hatano O; Honda S; Tsukiyama T; Niwa O; Hara T; Takakusu A; Shibata Y
Functional difference between Ad4BP and ELP, and their distributions in steroidogenic tissues.
Molecular endocrinology (Baltimore, Md.) 1994;8(5):643-53.
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1993: Morohashi K; Zanger U M; Honda S; Hara M; Waterman M R; Omura T
Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP.
Molecular endocrinology (Baltimore, Md.) 1993;7(9):1196-204.
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1993: Honda S; Morohashi K; Nomura M; Takeya H; Kitajima M; Omura T
Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily.
The Journal of biological chemistry 1993;268(10):7494-502.
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1993: Nomura M; Morohashi K; Kirita S; Nonaka Y; Okamoto M; Nawata H; Omura T
Three forms of rat CYP11B genes: 11 beta-hydroxylase gene, aldosterone synthase gene, and a novel gene.
Journal of biochemistry 1993;113(2):144-52.
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1992: Morohashi K
[Regulation of P-45011 beta gene (CYP11B) in steroidogenesis]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1992;37(16):3034-42.
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1992: Hashimoto T; Morohashi K; Takayama K; Honda S; Wada T; Handa H; Omura T
Cooperative transcription activation between Ad1, a CRE-like element, and other elements in the CYP11B gene promoter.
Journal of biochemistry 1992;112(5):573-5.
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1992: Morohashi K; Honda S; Inomata Y; Handa H; Omura T
A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s.
The Journal of biological chemistry 1992;267(25):17913-9.
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1992: Nonaka Y; Okamoto M; Morohashi K; Kirita S; Hashimoto T; Omura T
Functional expression of cDNAs for bovine 11 beta-hydroxylase-aldosterone synthases, P450(11 beta)-2 and -3 and their chimeras.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):779-80.
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1990: Ishihara S; Morohashi K; Sadano H; Kawabata S; Gotoh O; Omura T
Molecular cloning and sequence analysis of cDNA coding for rat liver hemoprotein H-450.
Journal of biochemistry 1990;108(6):899-902.
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1990: Morohashi K; Omura T
Tissue-specific transcription of P-450(11 beta) gene in vitro.
Journal of biochemistry 1990;108(6):1050-6.
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1990: Honda S; Morohashi K; Omura T
Novel cAMP regulatory elements in the promoter region of bovine P-450(11 beta) gene.
Journal of biochemistry 1990;108(6):1042-9.
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1990: Kirita S; Hashimoto T; Kitajima M; Honda S; Morohashi K; Omura T
Structural analysis of multiple bovine P-450(11 beta) genes and their promoter activities.
Journal of biochemistry 1990;108(6):1030-41.
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1990: Morohashi K; Nonaka Y; Kirita S; Hatano O; Takakusu A; Okamoto M; Omura T
Enzymatic activities of P-450(11 beta)s expressed by two cDNAs in COS-7 cells.
Journal of biochemistry 1990;107(4):635-40.
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1990: Sagara Y; Sawae H; Kimura A; Sagara-Nakano Y; Morohashi K; Miyoshi K; Horiuchi T
Structural organization of the bovine adrenodoxin gene.
Journal of biochemistry 1990;107(1):77-83.
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1989: Hashimoto T; Morohashi K; Omura T
Cloning and characterization of bovine cytochrome P-450(11 beta) genes.
Journal of biochemistry 1989;105(5):676-9.
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1988: Kirita S; Morohashi K; Hashimoto T; Yoshioka H; Fujii-Kuriyama Y; Omura T
Expression of two kinds of cytochrome P-450(11 beta) mRNA in bovine adrenal cortex.
Journal of biochemistry 1988;104(5):683-6.
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1988: Takagi Y; Morohashi K; Kawabata S; Go M; Omura T
Molecular cloning and nucleotide sequence of cDNA of microsomal carboxyesterase E1 of rat liver.
Journal of biochemistry 1988;104(5):801-6.
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1988: Hashimoto T; Matsumoto T; Nishizawa M; Kawabata S; Morohashi K; Handa S; Omura T
A mutant rat strain deficient in induction of a phenobarbital-inducible form of cytochrome P-450 in liver microsomes.
Journal of biochemistry 1988;103(3):487-92.
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1987: Iba K; Morohashi K; Miyata T; Takamiya K
Structural gene of cytochrome b-562 from the cytochrome b-c1 complex of Rhodobacter sphaeroides.
Journal of biochemistry 1987;102(6):1511-8.
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1987: Kumamoto T; Morohashi K; Ito A; Omura T
Site-directed mutagenesis of basic amino acid residues in the extension peptide of P-450(SCC) precursor: effects on the import of the precursor into mitochondria.
Journal of biochemistry 1987;102(4):833-8.
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1987: Morohashi K; Yoshioka H; Gotoh O; Okada Y; Yamamoto K; Miyata T; Sogawa K; Fujii-Kuriyama Y; Omura T
Molecular cloning and nucleotide sequence of DNA of mitochondrial cytochrome P-450(11 beta) of bovine adrenal cortex.
Journal of biochemistry 1987;102(3):559-68.
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1983: Morohashi K; Sadano H; Okada Y; Omura T
Position specificity in n-hexane hydroxylation by two forms of cytochrome P-450 in rat liver microsomes.
Journal of biochemistry 1983;93(2):413-9.
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