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Andrew Morris

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Andrew J Morris; Susan S Smyth
Lysophosphatidic acid and cardiovascular disease: seeing is believing.
Michael Spencer; Resat Unal; R Grace Walton; Beibei Zhu; Akosua Adu; Marilyn Campbell; Rod Erfani; Brian S Finlin; Jonah Lee; Robert E McGehee; Andrew J Morris; Charlotte A Peterson; Lindsey R Shipp; Philip Alfred Kern
Omega-3 Fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance.
Mayurranjan S Mitra; Andrew J Morris; Karim Nadra; Hongmei Ren; Xiong Su; Kari T Chambers; Zhouji Chen; Roman Chrast; Angela M Hall; Thurl E Harris; Samuel Klein; Brian N Finck
Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.

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All Publications

2013: Andrew J Morris; Susan S Smyth
Lysophosphatidic acid and cardiovascular disease: seeing is believing.
Journal of lipid research 2013;54(5):1153-5.
2013: Michael Spencer; Resat Unal; R Grace Walton; Beibei Zhu; Akosua Adu; Marilyn Campbell; Rod Erfani; Brian S Finlin; Jonah Lee; Robert E McGehee; Andrew J Morris; Charlotte A Peterson; Lindsey R Shipp; Philip Alfred Kern
Omega-3 Fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance.
Diabetes 2013;62(5):1709-17.
2013: Mayurranjan S Mitra; Andrew J Morris; Karim Nadra; Hongmei Ren; Xiong Su; Kari T Chambers; Zhouji Chen; Roman Chrast; Angela M Hall; Thurl E Harris; Samuel Klein; Brian N Finck
Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(2):642-7.
2013: Manikandan Panchatcharam; Abdelghaffar Salous; Manjula Sunkara; Jessica Wheeler; Anping Dong; Diana Escalante-Alcalde; Sumitra Miriyala; Andrew J Morris; Paul Mueller; Susan S Smyth
Lipid phosphate phosphatase 3 negatively regulates smooth muscle cell phenotypic modulation to limit intimal hyperplasia.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(1):52-9.
2012: Alejandra Mendoza; Andrew J Morris; Lauren A Pitt; Willy D Ramos-Perez; Béatrice Bréart; Michael Gobert; Juan J Lafaille; Manjula Sunkara; Susan R Schwab
The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate.
Cell reports 2012;2(5):1104-10.
2012: Gergana M Deevska; Andrew J Morris; Manjula Sunkara; Mariana Nikolova-Karakashian
Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr-/- mice fed on a high-fat diet.
Bioscience reports 2012;32(5):479-90.
2012: Amanda M Gellett; Yugesh Kharel; Andrew J Morris; Manjula Sunkara; Kevin R Lynch
Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.
Biochemical and biophysical research communications 2012;422(4):758-63.
2012: Jingjing Liu; Xiaoxi Liu; Andrew J Morris; Kylie E Newman; Aurora Pujol; Manjula Sunkara; Saloni Bhatnagar; J Andrew Brown; Xiangan Li; Shuang Liang; Gregory A Graf
The absence of ABCD2 sensitizes mice to disruptions in lipid metabolism by dietary erucic acid.
Journal of lipid research 2012;53(6):1071-9.
2012: Roberto Sánchez-Sánchez; Manjula Sunkara; José-Manuel Baizabal; Sara L Morales-Lázaro; Andrew J Morris; Diana Escalante-Alcalde
Lack of lipid phosphate phosphatase-3 in embryonic stem cells compromises neuronal differentiation and neurite outgrowth.
Developmental dynamics : an official publication of the American Association of Anatomists 2012;241(5):953-64.
2012: Yekaterina Y Zaytseva; Victoria A Elliott; Pat Gulhati; Eun Y Lee; Andrew J Morris; William C Mustain; Kathleen O'Connor; Piotr G Rychahou; Manjula Sunkara; Heidi L Weiss; B Mark Evers
Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer.
Cancer research 2012;72(6):1504-17.
2012: Binggang Xiang; Guoying Zhang; T Kent Gartner; Andrew J Morris; Hongmei Ren; Susan S Smyth; Manjula Sunkara; Zhenyu Li
The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism.
PloS one 2012;7(12):e51037.
2012: Anping Dong; Andrew J Morris; Manikandan Panchatcharam; Abdel Salous; Samy Selim; Manjula Sunkara; Susan S Smyth
Synergistic effect of anemia and red blood cells transfusion on inflammation and lung injury.
Advances in hematology 2012;2012():924042.
2011: Béatrice Bréart; Diana Escalante-Alcalde; Michael Gobert; Yong Huang; Juan J Lafaille; Alejandra Mendoza; Andrew J Morris; Willy D Ramos-Perez; Abdelghaffar K Salous; Ralf H Adams; Susan R Schwab
Lipid phosphate phosphatase 3 enables efficient thymic egress.
The Journal of experimental medicine 2011;208(6):1267-78.
2011: Alejandro López-Juárez; Sara Morales-Lázaro; Roberto Sánchez-Sánchez; Manjula Sunkara; Hilda Lomelí; Iván Velasco; Andrew J Morris; Diana Escalante-Alcalde
Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development.
Glia 2011;59(4):577-89.
2011: Huiyan Huang; Qun Gao; Xiaoxue Peng; Seok-Yong Choi; Krishna Sarma; Hongmei Ren; Andrew J Morris; Michael A Frohman
piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling.
Developmental cell 2011;20(3):376-87.
2011: Zuzana Majkova; Joseph Layne; Manjula Sunkara; Andrew J Morris; Michal J Toborek; Bernhard Hennig
Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls.
Toxicology and applied pharmacology 2011;251(1):41-9.
2011: Zhaofei Wu; Xiang Li; Andrew J Morris; Heather Spearman; Manjula Sunkara; Cai Huang
PIPKIγ regulates focal adhesion dynamics and colon cancer cell invasion.
PloS one 2011;6(9):e24775.
2010: Hongmei Ren; Lorenzo Federico; Huiyan Huang; Manjula Sunkara; Tracy Drennan; Michael A Frohman; Susan S Smyth; Andrew J Morris
A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis.
Molecular biology of the cell 2010;21(18):3171-81.
2010: Manikandan Panchatcharam; Sumitra Miriyala; Fanmuyi Yang; Michael Leitges; Magdalena Wodnicka; Lawrence A Quilliam; Paul Anaya; Andrew J Morris; Susan Smyth
Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling.
The international journal of biochemistry & cell biology 2010;42(6):965-74.
2010: Sumitra Miriyala; Thangaiah Subramanian; Manikandan Panchatcharam; Hongmei Ren; Mark I McDermott; Manjula Sunkara; Tracy Drennan; Susan S Smyth; H Peter Spielmann; Andrew J Morris
Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells.
The Journal of biological chemistry 2010;285(18):13918-29.
2010: Thomas P Mathews; Andrew J Kennedy; Yugesh Kharel; Perry C Kennedy; Oana Nicoara; Manjula Sunkara; Andrew J Morris; Brian R Wamhoff; Kevin R Lynch; Timothy L MacDonald
Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors.
Journal of medicinal chemistry 2010;53(7):2766-78.
2010: Boris B Boyanovsky; Xia Li; preetha shridas; Manjula Sunkara; Andrew J Morris; Nancy R Webb
Bioactive products generated by group V sPLA(2) hydrolysis of LDL activate macrophages to secrete pro-inflammatory cytokines.
Cytokine 2010;50(1):50-7.
2009: Christian Riebeling; Andrew J Morris; Dennis Shields
Phospholipase D in the Golgi apparatus.
Biochimica et biophysica acta 2009;1791(9):876-80.
2009: Andrew J Morris; Samy Selim; Abdel Salous; Susan Smyth
Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation.
Trends in cardiovascular medicine 2009;19(4):135-40.
2009: Dane Meredith; Manikandan Panchatcharam; Sumitra Miriyala; Yau-Sheng Tsai; Andrew J Morris; Nobuyo Maeda; George A Stouffer; Susan Smyth
Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(4):465-71.
2009: Zehra Pamuklar; Lorenzo Federico; Shuying Liu; Makiko Umezu-Goto; Anping Dong; Manikandan Panchatcharam; Zachary Fulkerson; Zachary Fulerson; Evgeny Berdyshev; Viswanathan Natarajan; Xianjun Fang; Laurens van Meeteren; Wouter H Moolenaar; Gordon B Mills; Andrew J Morris; Susan Smyth
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis.
The Journal of biological chemistry 2009;284(11):7385-94.
2009: Wenjuan Su; Oladapo Yeku; Srinivas Olepu; Alyssa Genna; Jae-Sook Park; Hongmei Ren; Guangwei Du; Michael H Gelb; Andrew J Morris; Michael A Frohman
5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.
Molecular pharmacology 2009;75(3):437-46.
2008: Manikandan Panchatcharam; Sumitra Miriyala; Fanmuyi Yang; Mauricio Rojas; Christopher End; Christopher Vallant; Anping Dong; Kevin Lynch; Jerold Chun; Andrew J Morris; Susan Smyth
Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure.
Circulation research 2008;103(6):662-70.
2008: Susan Smyth; Hsin-Yuan Cheng; Sumitra Miriyala; Manikandan Panchatcharam; Andrew J Morris
Roles of lysophosphatidic acid in cardiovascular physiology and disease.
Biochimica et biophysica acta 2008;1781(9):563-70.
2008: Lorenzo Federico; Zehra Pamuklar; Susan Smyth; Andrew J Morris
Therapeutic potential of autotaxin/lysophospholipase d inhibitors.
Current drug targets 2008;9(8):698-708.
2008: Zehra Pamuklar; Jin Sun Lee; Hsin-Yuan Cheng; Manikandan Panchatcharam; Steven R Steinhubl; Andrew J Morris; Richard Charnigo; Susan Smyth
Individual heterogeneity in platelet response to lysophosphatidic acid: evidence for a novel inhibitory pathway.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(3):555-61.
2007: Yury J Sigal; Omar A Quintero; Richard E Cheney; Andrew J Morris
Cdc42 and ARP2/3-independent regulation of filopodia by an integral membrane lipid-phosphatase-related protein.
Journal of cell science 2007;120(Pt 2):340-52.
2007: Andrew J Morris; Susan Smyth
Measurement of autotaxin/lysophospholipase D activity.
Methods in enzymology 2007;434():89-104.
2007: Andrew J Morris
Regulation of phospholipase D activity, membrane targeting and intracellular trafficking by phosphoinositides.
Biochemical Society symposium 2007;(74):247-57.
2006: Mark I McDermott; Yury J Sigal; Joshua S Crump; Andrew J Morris
Enzymatic analysis of lipid phosphate phosphatases.
Methods (San Diego, Calif.) 2006;39(2):169-79.
2006: Koichi Fukunaga; Makoto Arita; Minoru Takahashi; Andrew J Morris; Michael Pfeffer; Bruce D Levy
Identification and functional characterization of a presqualene diphosphate phosphatase.
The Journal of biological chemistry 2006;281(14):9490-7.
2005: Marcia M Taylor; Kendra Macdonald; Andrew J Morris; Christopher R McMaster
Enhanced apoptosis through farnesol inhibition of phospholipase D signal transduction.
The FEBS journal 2005;272(19):5056-63.
2005: Bruce D Levy; Lorraine Hickey; Andrew J Morris; Mykol Larvie; Raquel Keledjian; Nicos A Petasis; Gerard Bannenberg; Charles N Serhan
Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo.
British journal of pharmacology 2005;146(3):344-51.
2005: Yury J Sigal; Mark I McDermott; Andrew J Morris
Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions.
The Biochemical journal 2005;387(Pt 2):281-93.
2004: Andrew D Renault; Y J Sigal; Andrew J Morris; Ruth Lehmann
Soma-germ line competition for lipid phosphate uptake regulates germ cell migration and survival.
Science (New York, N.Y.) 2004;305(5692):1963-6.
2004: Mark I McDermott; Yury J Sigal; Vicki A Sciorra; Andrew J Morris
Is PRG-1 a new lipid phosphatase?
Nature neuroscience 2004;7(8):789; author reply 789-90.
2004: Wen-Shu Sun; Atsushi Imai; Michiyo Sugiyama; Tatsuro Furui; Teruhiko Tamaya; Masanao Saio; Andrew J Morris
Translocation of lysophosphatidic acid phosphatase in response to gonadotropin-releasing hormone to the plasma membrane in ovarian cancer cell.
American journal of obstetrics and gynecology 2004;191(1):143-9.
2004: Leslie T Grab; Mary W Kearns; Andrew J Morris; Larry W Daniel
Differential role for phospholipase D1 and phospholipase D2 in 12-O-tetradecanoyl-13-phorbol acetate-stimulated MAPK activation, Cox-2 and IL-8 expression.
Biochimica et biophysica acta 2004;1636(1):29-39.
2004: Mark McDermott; Michael J O Wakelam; Andrew J Morris
Phospholipase D.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2004;82(1):225-53.
2004: Simon A Rudge; Vicki A Sciorra; Michelle Iwamoto; Chun Zhou; Thomas Strahl; Andrew J Morris; Jeremy Thorner; JoAnne Engebrecht
Roles of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation.
Molecular biology of the cell 2004;15(1):207-18.
2003: Susan Smyth; Vicki A Sciorra; Yury J Sigal; Zehra Pamuklar; Zuncai Wang; Yong Xu; Glenn D Prestwich; Andrew J Morris
Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity.
The Journal of biological chemistry 2003;278(44):43214-23.
2003: Diana Escalante-Alcalde; Lidia Hernandez; Hervé Le Stunff; Ryu Maeda; Hyun-Shik Lee; Vicki A Sciorra; Ira O Daar; Sarah Spiegel; Andrew J Morris; Colin L Stewart
The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning.
Development (Cambridge, England) 2003;130(19):4623-37.
2003: Celine Luquain; Anurag Singh; Lixin Wang; Viswanathan Natarajan; Andrew J Morris
Role of phospholipase D in agonist-stimulated lysophosphatidic acid synthesis by ovarian cancer cells.
Journal of lipid research 2003;44(10):1963-75.
2003: Janos L Tanyi; Yutaka Hasegawa; Ruth Lapushin; Andrew J Morris; Judith K Wolf; Andrew Berchuck; Karen Lu; David I Smith; Kimberly R Kalli; Lynn C Hartmann; Karen McCune; David Fishman; Russell R Broaddus; Kwai Wa Cheng; E Neely Atkinson; Jose-Miguel Yamal; Robert C Bast; Edward Felix; Robert A Newman; Gordon B Mills
Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3534-45.
2003: Vytas A Bankaitis; Andrew J Morris
Lipids and the exocytotic machinery of eukaryotic cells.
Current opinion in cell biology 2003;15(4):389-95.
2003: Guangwei Du; Yelena M Altshuller; Nicolas Vitale; Ping Huang; Sylvette Chasserot-Golaz; Andrew J Morris; Marie-France Bader; Michael A Frohman
Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs.
The Journal of cell biology 2003;162(2):305-15.
2003: Celine Luquain; Vicki A Sciorra; Andrew J Morris
Lysophosphatidic acid signaling: how a small lipid does big things.
Trends in biochemical sciences 2003;28(7):377-83.
2003: Janos L Tanyi; Andrew J Morris; Judith K Wolf; Xianjun Fang; Yutaka Hasegawa; Ruth Lapushin; Nelly Auersperg; Yury J Sigal; Robert A Newman; Edward Felix; E Neely Atkinson; Gordon B Mills
The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.
Cancer research 2003;63(5):1073-82.
2002: Vicki A Sciorra; Simon A Rudge; Jiyao Wang; Stuart McLaughlin; JoAnne Engebrecht; Andrew J Morris
Dual role for phosphoinositides in regulation of yeast and mammalian phospholipase D enzymes.
The Journal of cell biology 2002;159(6):1039-49.
2002: Vicki A Sciorra; Andrew J Morris
Roles for lipid phosphate phosphatases in regulation of cellular signaling.
Biochimica et biophysica acta 2002;1582(1-3):45-51.
2002: Sylvain G Bourgoin; Martin G Houle; Indrapal N Singh; Danielle Harbour; Steve Gagnon; Andrew J Morris; David N Brindley
ARNO but not cytohesin-1 translocation is phosphatidylinositol 3-kinase-dependent in HL-60 cells.
Journal of leukocyte biology 2002;71(4):718-28.
2002: Guangwei Du; Andrew J Morris; Vicki A Sciorra; Michael A Frohman
G-protein-coupled receptor regulation of phospholipase D.
Methods in enzymology 2002;345():265-74.
2001: Narasimham L Parinandi; Shukla Roy; Shu Shi; Rhett J Cummings; Andrew J Morris; Joe G. N. Garcia; Viswanathan Natarajan
Role of Src kinase in diperoxovanadate-mediated activation of phospholipase D in endothelial cells.
Archives of biochemistry and biophysics 2001;396(2):231-43.
2001: Indrapal N Singh; L M Stromberg; Sylvain G Bourgoin; V A Sciorra; Andrew J Morris; David N Brindley
Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate.
Biochemistry 2001;40(37):11227-33.
2001: Massimo Locati; Elena Riboldi; Raffaella Bonecchi; Pietro Transidico; Sergio Bernasconi; Haribabu Bodduluri; Andrew J Morris; Alberto Mantovani; Silvano Sozzani
Selective induction of phospholipase D1 in pathogen-activated human monocytes.
The Biochemical journal 2001;358(Pt 1):119-25.
2001: Viswanathan Natarajan; WM Scribner; Andrew J Morris; Shukla Roy; Suryanarayana Vepa; J Yang; Raj Wadgaonkar; SEKHAR POTHIREDDY; Joe G. N. Garcia; Narasimham L Parinandi
Role of p38 MAP kinase in diperoxovanadate-induced phospholipase D activation in endothelial cells.
American journal of physiology. Lung cellular and molecular physiology 2001;281(2):L435-49.
2001: Nicolas Vitale; AS Caumont; Sylvette Chasserot-Golaz; G Du; S Wu; Vicki A Sciorra; Andrew J Morris; Michael A Frohman; Marie-France Bader
Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells.
The EMBO journal 2001;20(10):2424-34.
2001: James R Erickson; Yutaka Hasegawa; Xiang Fang; Astrid Eder; Muling Mao; Tatsuro Furui; Junken Aoki; Andrew J Morris; Gordon B Mills
Lysophosphatidic acid and ovarian cancer: a paradigm for tumorogenesis and patient management.
Prostaglandins & other lipid mediators 2001;64(1-4):63-81.
2001: Vicki A Sciorra; Scott M Hammond; Andrew J Morris
Potent direct inhibition of mammalian phospholipase D isoenzymes by calphostin-c.
Biochemistry 2001;40(8):2640-6.
2000: Guangwei Du; Yelena M Altshuller; Y Kim; J M Han; S H Ryu; Andrew J Morris; Michael A Frohman
Dual requirement for rho and protein kinase C in direct activation of phospholipase D1 through G protein-coupled receptor signaling.
Molecular biology of the cell 2000;11(12):4359-68.
2000: Alexey N Pronin; Andrew J Morris; A Surguchov; Jeffrey L Benovic
Synucleins are a novel class of substrates for G protein-coupled receptor kinases.
The Journal of biological chemistry 2000;275(34):26515-22.
2000: R Z Roberts; Andrew J Morris
Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators.
Biochimica et biophysica acta 2000;1487(1):33-49.
2000: Anna Arbuzova; K Martushova; Gyöngyi Hangyás-Mihályné; Andrew J Morris; S Ozaki; Glenn D Prestwich; Stuart McLaughlin
Fluorescently labeled neomycin as a probe of phosphatidylinositol-4, 5-bisphosphate in membranes.
Biochimica et biophysica acta 2000;1464(1):35-48.
2000: Michael A Frohman; Yasunori Kanaho; Yue Zhang; Andrew J Morris
Regulation of phospholipase D1 activity by Rho GTPases.
Methods in enzymology 2000;325():177-89.
1999: A Honda; Masahiro Nogami; Takeaki Yokozeki; Masakazu Yamazaki; H Nakamura; Hajime Watanabe; K Kawamoto; Kazuhisa Nakayama; Andrew J Morris; Michael A Frohman; Yasunori Kanaho
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation.
Cell 1999;99(5):521-32.
1999: Yue Zhang; Yelena M Altshuller; Scott M Hammond; F Hayes; Andrew J Morris; Michael A Frohman
Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C.
The EMBO journal 1999;18(22):6339-48.
1999: Vicki A Sciorra; Andrew J Morris
Sequential actions of phospholipase D and phosphatidic acid phosphohydrolase 2b generate diglyceride in mammalian cells.
Molecular biology of the cell 1999;10(11):3863-76.
1999: Vicki A Sciorra; Simon A Rudge; Glenn D Prestwich; Michael A Frohman; JoAnne Engebrecht; Andrew J Morris
Identification of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes.
The EMBO journal 1999;18(21):5911-21.
1999: Andrew J Morris; Craig C Malbon
Physiological regulation of G protein-linked signaling.
Physiological reviews 1999;79(4):1373-430.
1999: Michael A Frohman; T C Sung; Andrew J Morris
Mammalian phospholipase D structure and regulation.
Biochimica et biophysica acta 1999;1439(2):175-86.
1999: Michael A Frohman; Andrew J Morris
Phospholipase D structure and regulation.
Chemistry and physics of lipids 1999;98(1-2):127-40.
1999: T C Sung; Yue Zhang; Andrew J Morris; Michael A Frohman
Structural analysis of human phospholipase D1.
The Journal of biological chemistry 1999;274(6):3659-66.
1999: T C Sung; Yelena M Altshuller; Andrew J Morris; Michael A Frohman
Molecular analysis of mammalian phospholipase D2.
The Journal of biological chemistry 1999;274(1):494-502.
1998: R Roberts; V A Sciorra; Andrew J Morris
Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.
The Journal of biological chemistry 1998;273(34):22059-67.
1998: Simon A Rudge; M M Cavenagh; R Kamath; Vicki A Sciorra; Andrew J Morris; Richard A Kahn; JoAnne Engebrecht
ADP-Ribosylation factors do not activate yeast phospholipase Ds but are required for sporulation.
Molecular biology of the cell 1998;9(8):2025-36.
1998: Ayse G Kayali; Jens Eichhorn; T Haruta; Andrew J Morris; JG Nelson; P Vollenweider; Jerrold M Olefsky; Nicholas J G Webster
Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin.
The Journal of biological chemistry 1998;273(22):13808-18.
1998: J M Jenco; A Rawlingson; B Daniels; Andrew J Morris
Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins.
Biochemistry 1998;37(14):4901-9.
1998: JQ Luo; X Liu; Paul Frankel; Thuy Rotunda; M Ramos; J Flom; H Jiang; Larry A Feig; Andrew J Morris; Richard A Kahn; David A Foster
Functional association between Arf and RalA in active phospholipase D complex.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3632-7.
1998: Simon A Rudge; Andrew J Morris; JoAnne Engebrecht
Relocalization of phospholipase D activity mediates membrane formation during meiosis.
The Journal of cell biology 1998;140(1):81-90.
1998: T Haruta; Andrew J Morris; P Vollenweider; JG Nelson; David W Rose; M Mueckler; Jerrold M Olefsky
Ligand-independent GLUT4 translocation induced by guanosine 5'-O-(3-thiotriphosphate) involves tyrosine phosphorylation.
Endocrinology 1998;139(1):358-64.
1997: J O Liang; T C Sung; Andrew J Morris; Michael A Frohman; Stuart Kornfeld
Different domains of mammalian ADP-ribosylation factor 1 mediate interaction with selected target proteins.
The Journal of biological chemistry 1997;272(52):33001-8.
1997: Andrew J Morris; Scott M Hammond; C Colley; TC Sung; JM Jenco; Vicki A Sciorra; Simon A Rudge; Michael A Frohman
Regulation and functions of phospholipase D.
Biochemical Society transactions 1997;25(4):1151-7.
1997: P Vollenweider; Stuart S Martin; T Haruta; Andrew J Morris; JG Nelson; Mireille Cormont; Yannick Le Marchand-Brustel; David W Rose; Jerrold M Olefsky
The small guanosine triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells.
Endocrinology 1997;138(11):4941-9.
1997: J M Jenco; K P Becker; Andrew J Morris
Membrane-binding properties of phospholipase C-beta1 and phospholipaseC-beta2: role of the C-terminus and effects of polyphosphoinositides, G-proteins and Ca2+.
The Biochemical journal 1997;327 ( Pt 2)():431-7.
1997: Andrew J Morris; Michael A Frohman; JoAnne Engebrecht
Measurement of phospholipase D activity.
Analytical biochemistry 1997;252(1):1-9.
1997: Andrew J Morris; S Scarlata
Regulation of effectors by G-protein alpha- and beta gamma-subunits. Recent insights from studies of the phospholipase c-beta isoenzymes.
Biochemical pharmacology 1997;54(4):429-35.
1997: Y G Chen; Anirban Siddhanta; C D Austin; Scott M Hammond; TC Sung; Michael A Frohman; Andrew J Morris; Dennis Shields
Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network.
The Journal of cell biology 1997;138(3):495-504.
1997: TC Sung; R L Roper; Yue Zhang; Simon A Rudge; R Temel; Scott M Hammond; Andrew J Morris; Bernard Moss; JoAnne Engebrecht; Michael A Frohman
Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity.
The EMBO journal 1997;16(15):4519-30.
1997: JQ Luo; X Liu; Scott M Hammond; WC Colley; Larry A Feig; Michael A Frohman; Andrew J Morris; David A Foster
RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1.
Biochemical and biophysical research communications 1997;235(3):854-9.
1997: Chunghee Lee; H S Kang; JK Chung; Fujio Sekiya; Jae-Ryong Kim; J S Han; SR Kim; Yun Soo Bae; Andrew J Morris; Sue Goo Rhee
Inhibition of phospholipase D by clathrin assembly protein 3 (AP3).
The Journal of biological chemistry 1997;272(25):15986-92.
1997: JK Chung; Fujio Sekiya; H S Kang; Chunghee Lee; J S Han; SR Kim; Yun Soo Bae; Andrew J Morris; Sue Goo Rhee
Synaptojanin inhibition of phospholipase D activity by hydrolysis of phosphatidylinositol 4,5-bisphosphate.
The Journal of biological chemistry 1997;272(25):15980-5.
1997: WC Colley; TC Sung; R Roll; JM Jenco; Scott M Hammond; Yelena M Altshuller; D Bar-Sagi; Andrew J Morris; Michael A Frohman
Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization.
Current biology : CB 1997;7(3):191-201.
1997: Scott M Hammond; JM Jenco; S Nakashima; K Cadwallader; Q Gu; S Cook; Y Nozawa; G D Prestwich; Michael A Frohman; Andrew J Morris
Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha.
The Journal of biological chemistry 1997;272(6):3860-8.
1996: L W Runnels; J Jenco; Andrew J Morris; suzanne scarlata
Membrane binding of phospholipases C-beta 1 and C-beta 2 is independent of phosphatidylinositol 4,5-bisphosphate and the alpha and beta gamma subunits of G proteins.
Biochemistry 1996;35(51):16824-32.
1996: Michael Glaser; S Wanaski; C A Buser; V Boguslavsky; W Rashidzada; Andrew J Morris; Mario J Rebecchi; suzanne scarlata; L W Runnels; Glenn D Prestwich; J Chen; A Aderem; J Ahn; Stuart McLaughlin
Myristoylated alanine-rich C kinase substrate (MARCKS) produces reversible inhibition of phospholipase C by sequestering phosphatidylinositol 4,5-bisphosphate in lateral domains.
The Journal of biological chemistry 1996;271(42):26187-93.
1996: Andrew J Morris; Stuart S Martin; T Haruta; JG Nelson; P Vollenweider; TA Gustafson; M Mueckler; David W Rose; Jerrold M Olefsky
Evidence for an insulin receptor substrate 1 independent insulin signaling pathway that mediates insulin-responsive glucose transporter (GLUT4) translocation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8401-6.
1996: M A Frohman; Andrew J Morris
Rho is only ARF the story. Phospholipid signalling.
Current biology : CB 1996;6(8):945-7.
1996: Stuart S Martin; T Haruta; Andrew J Morris; A Klippel; L T Williams; Jerrold M Olefsky
Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes.
The Journal of biological chemistry 1996;271(30):17605-8.
1996: Andrew J Morris; JoAnne Engebrecht; Michael A Frohman
Structure and regulation of phospholipase D.
Trends in pharmacological sciences 1996;17(5):182-5.
1995: K Rose; Simon A Rudge; Michael A Frohman; Andrew J Morris; JoAnne Engebrecht
Phospholipase D signaling is essential for meiosis.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12151-5.
1995: Scott M Hammond; Yelena M Altshuller; TC Sung; Simon A Rudge; K Rose; JoAnne Engebrecht; Andrew J Morris; Michael A Frohman
Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family.
The Journal of biological chemistry 1995;270(50):29640-3.
1995: P Garcia; R Gupta; S Shah; Andrew J Morris; S A Rudge; suzanne scarlata; V Petrova; Stuart McLaughlin; Mario J Rebecchi
The pleckstrin homology domain of phospholipase C-delta 1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes.
Biochemistry 1995;34(49):16228-34.
1995: T Haruta; Andrew J Morris; David W Rose; JG Nelson; M Mueckler; Jerrold M Olefsky
Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway.
The Journal of biological chemistry 1995;270(47):27991-4.
1995: A Paterson; José L Boyer; Val Watts; Andrew J Morris; E M Price; T Kendall Harden
Concentration of enzyme-dependent activation of PLC-beta 1 and PLC-beta 2 by G alpha 11 and beta gamma-subunits.
Cellular signalling 1995;7(7):709-20.
1995: Andrew J Morris; Simon A Rudge; C E Mahlum; J M Jenco
Regulation of phosphoinositide-3-kinase by G protein beta gamma subunits in a rat osteosarcoma cell line.
Molecular pharmacology 1995;48(3):532-9.
1994: D C Watkins; C M Moxham; Andrew J Morris; Craig C Malbon
Suppression of Gi alpha 2 enhances phospholipase C signalling.
The Biochemical journal 1994;299 ( Pt 3)():593-6.
1994: V Boguslavsky; Mario J Rebecchi; Andrew J Morris; D Y Jhon; S G Rhee; Stuart McLaughlin
Effect of monolayer surface pressure on the activities of phosphoinositide-specific phospholipase C-beta 1, -gamma 1, and -delta 1.
Biochemistry 1994;33(10):3032-7.
1994: G L Waldo; Andrew J Morris; T Kendall Harden
Purification of G-protein-regulated phospholipase C from turkey erythrocytes.
Methods in enzymology 1994;238():195-207.
1993: D H Maurice; G L Waldo; Andrew J Morris; Robert A Nicholas; T Kendall Harden
Identification of G alpha 11 as the phospholipase C-activating G-protein of turkey erythrocytes.
The Biochemical journal 1993;290 ( Pt 3)():765-70.
1992: N S Wong; C J Barker; Andrew J Morris; A Craxton; C J Kirk; Robert H Michell
The inositol phosphates in WRK1 rat mammary tumour cells.
The Biochemical journal 1992;286 ( Pt 2)():459-68.
1991: G L Waldo; Andrew J Morris; David Klapper; T Kendall Harden
Receptor- and G-protein-regulated 150-kDa avian phospholipase C: inhibition of enzyme activity by isoenzyme-specific antisera and nonidentity with mammalian phospholipase C isoenzymes established by immunoreactivity and peptide sequence.
Molecular pharmacology 1991;40(4):480-9.
1991: G L Waldo; José L Boyer; Andrew J Morris; T Kendall Harden
Purification of an AlF4- and G-protein beta gamma-subunit-regulated phospholipase C-activating protein.
The Journal of biological chemistry 1991;266(22):14217-25.
1991: T Kendall Harden; Andrew J Morris; G L Waldo; C P Downes; José L Boyer
Avian G-protein-regulated phospholipase C.
Biochemical Society transactions 1991;19(2):342-6.
1990: Andrew J Morris; G L Waldo; C P Downes; T Kendall Harden
A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. II. P2Y-purinergic receptor and G-protein-mediated regulation of the purified enzyme reconstituted with turkey erythrocyte ghosts.
The Journal of biological chemistry 1990;265(23):13508-14.
1990: Andrew J Morris; G L Waldo; C P Downes; T Kendall Harden
A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. I. Purification and properties.
The Journal of biological chemistry 1990;265(23):13501-7.
1990: Andrew J Morris; G L Waldo; José L Boyer; J R Hepler; C P Downes; T Kendall Harden
Regulation of phospholipase C.
Society of General Physiologists series 1990;45():61-75.
1989: C L Cooper; Andrew J Morris; T Kendall Harden
Guanine nucleotide-sensitive interaction of a radiolabeled agonist with a phospholipase C-linked P2y-purinergic receptor.
The Journal of biological chemistry 1989;264(11):6202-6.
1988: Andrew J Morris; D J Storey; C P Downes; Robert H Michell
Dephosphorylation of 1D-myo-inositol 1,4-bisphosphate in rat liver.
The Biochemical journal 1988;254(3):655-60.
1988: Andrew J Morris; K J Murray; P J England; C P Downes; Robert H Michell
Partial purification and some properties of rat brain inositol 1,4,5-trisphosphate 3-kinase.
The Biochemical journal 1988;251(1):157-63.
1988: Len Stephens; Phillip T Hawkins; N Carter; S B Chahwala; Andrew J Morris; A D Whetton; P C Downes
L-myo-inositol 1,4,5,6-tetrakisphosphate is present in both mammalian and avian cells.
The Biochemical journal 1988;249(1):271-82.
1988: Len R Stephens; Phillip T Hawkins; Andrew J Morris; P C Downes
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase.
The Biochemical journal 1988;249(1):283-92.
1987: Andrew J Morris; C P Downes; T Kendall Harden; Robert H Michell
Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca2+ in the presence of calmodulin.
The Biochemical journal 1987;248(2):489-93.
1987: Phillip T Hawkins; C P Berrie; Andrew J Morris; C P Downes
Inositol 1,2-cyclic 4,5-trisphosphate is not a product of muscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis in rat parotid glands.
The Biochemical journal 1987;243(1):211-8.
1987: S B Shears; D J Storey; Andrew J Morris; A B Cubitt; J B Parry; Robert H Michell; C J Kirk
Dephosphorylation of myo-inositol 1,4,5-trisphosphate and myo-inositol 1,3,4-triphosphate.
The Biochemical journal 1987;242(2):393-402.
1974: Andrew J Morris; R C Slabaugh; A Protzel
Size characteristics of nascent globin chains (peptidyl tRNA) in the reticulocyte.
Annals of the New York Academy of Sciences 1974;241(0):310-21.