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Charles Morrow

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Lisa P Rudd; Sandra L Kabler; Charles S Morrow; Alan J Townsend
Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1).
Darcy J P Bates; S Bruce King; Pamela K Smitherman; Alan J Townsend; Charles S Morrow
Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPARγ-dependent transcription by distinct signaling pathways and with significantly different potencies.
Michael J Gorczynski; Pamela K Smitherman; Taro E Akiyama; Harold B Wood; Joel P Berger; S Bruce King; Charles S Morrow
Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation.

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All Publications

2011: Lisa P Rudd; Sandra L Kabler; Charles S Morrow; Alan J Townsend
Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1).
Chemico-biological interactions 2011;194(2-3):113-9.
2011: Darcy J P Bates; S Bruce King; Pamela K Smitherman; Alan J Townsend; Charles S Morrow
Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPARγ-dependent transcription by distinct signaling pathways and with significantly different potencies.
Biochemistry 2011;50(36):7765-73.
2009: Michael J Gorczynski; Pamela K Smitherman; Taro E Akiyama; Harold B Wood; Joel P Berger; S Bruce King; Charles S Morrow
Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation.
Journal of medicinal chemistry 2009;52(15):4631-9.
2009: Darcy J P Bates; Mark Lively; Michael J Gorczynski; S Bruce King; Alan J Townsend; Charles S Morrow
Noncatalytic interactions between glutathione S-transferases and nitroalkene fatty acids modulate nitroalkene-mediated activation of peroxisomal proliferator-activated receptor gamma.
Biochemistry 2009;48(19):4159-69.
2009: Sandra L Kabler; Albrecht Seidel; Juergen Jacob; Johannes Doehmer; Charles S Morrow; Alan J Townsend
Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.
Chemico-biological interactions 2009;179(2-3):240-6.
2009: Richard L Alexander; Marcus W Wright; Michael J Gorczynski; Pamela K Smitherman; Taro E Akiyama; Harold B Wood; Joel P Berger; S Bruce King; Charles S Morrow
Differential potencies of naturally occurring regioisomers of nitrolinoleic acid in PPARgamma activation.
Biochemistry 2009;48(2):492-8.
2008: Sarfaraz Ahmad; Sandra L Kabler; Lisa Rudd; Shantu Amin; Johannes Doehmer; Charles S Morrow; Alan J Townsend
Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression.
Toxicology letters 2008;183(1-3):99-104.
2008: Christina Peklak-Scott; Pamela K Smitherman; Alan J Townsend; Charles S Morrow
Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin.
Molecular cancer therapeutics 2008;7(10):3247-55.
2008: Mebrahtu B Sibhatu; Pamela K Smitherman; Alan J Townsend; Charles S Morrow
Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane.
Carcinogenesis 2008;29(4):807-15.
2007: Mary E Kushman; Sandra L Kabler; Sarfaraz Ahmad; Johannes Doehmer; Charles S Morrow; Alan J Townsend
Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (+/-)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1.
Mutation research 2007;624(1-2):80-7.
2007: Mary E Kushman; Sandra L Kabler; Sarfaraz Ahmad; Johannes Doehmer; Charles S Morrow; Alan J Townsend
Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1.
Toxicological sciences : an official journal of the Society of Toxicology 2007;99(1):51-7.
2007: Mary E Kushman; Sandra L Kabler; Melissa H Fleming; Srivani Ravoori; Ramesh C Gupta; Johannes Doehmer; Charles S Morrow; Alan J Townsend
Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1.
Carcinogenesis 2007;28(1):207-14.
2006: Richard L Alexander; Darcy J P Bates; Marcus W Wright; S Bruce King; Charles S Morrow
Modulation of nitrated lipid signaling by multidrug resistance protein 1 (MRP1): glutathione conjugation and MRP1-mediated efflux inhibit nitrolinoleic acid-induced, PPARgamma-dependent transcription activation.
Biochemistry 2006;45(25):7889-96.
2006: Charles S Morrow; Christina Peklak-Scott; Bimjhana Bishwokarma; Timothy E Kute; Pamela K Smitherman; Alan J Townsend
Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux.
Molecular pharmacology 2006;69(4):1499-505.
2005: Joseph T O'Flaherty; LeAnn C Rogers; Christian Paumi; Roy R Hantgan; Lance R Thomas; Carl Clay; Kevin High; Yong Q Chen; Mark C Willingham; Pamela K Smitherman; Timothy E Kute; Anuradha Rao; Scott D Cramer; Charles S Morrow
5-Oxo-ETE analogs and the proliferation of cancer cells.
Biochimica et biophysica acta 2005;1736(3):228-36.
2005: David S Riddick; Chunja Lee; Shairoz Ramji; Edwin C Chinje; Rachel L Cowen; Kaye J Williams; Adam Patterson; Ian J Stratford; Charles S Morrow; Alan J Townsend; Youssef Jounaidi; Chong-Sheng Chen; Ting Su; Hong Lu; Pamela S Schwartz; David J Waxman
Cancer chemotherapy and drug metabolism.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(8):1083-96.
2005: Christina Peklak-Scott; Alan J Townsend; Charles S Morrow
Dynamics of glutathione conjugation and conjugate efflux in detoxification of the carcinogen, 4-nitroquinoline 1-oxide: contributions of glutathione, glutathione S-transferase, and MRP1.
Biochemistry 2005;44(11):4426-33.
2004: Christian Paumi; Pamela K Smitherman; Alan J Townsend; Charles S Morrow
Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2).
Biochemistry 2004;43(8):2345-52.
2004: Pamela K Smitherman; Alan J Townsend; Timothy E Kute; Charles S Morrow
Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity.
The Journal of pharmacology and experimental therapeutics 2004;308(1):260-7.
2003: Christian Paumi; Marcus Wright; Alan J Townsend; Charles S Morrow
Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells.
Biochemistry 2003;42(18):5429-37.
2002: Alan J Townsend; Sandra L Kabler; Johannes Doehmer; Charles S Morrow
Modeling the metabolic competency of glutathione S-transferases using genetically modified cell lines.
Toxicology 2002;181-182():265-9.
2001: SK Diah; Pamela K Smitherman; J Aldridge; E L Volk; E Schneider; Alan J Townsend; Charles S Morrow
Resistance to mitoxantrone in multidrug-resistant MCF7 breast cancer cells: evaluation of mitoxantrone transport and the role of multidrug resistance protein family proteins.
Cancer research 2001;61(14):5461-7.
2001: Christian Paumi; B G Ledford; Pamela K Smitherman; Alan J Townsend; Charles S Morrow
Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance. Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity.
The Journal of biological chemistry 2001;276(11):7952-6.
2000: Charles S Morrow; Pamela K Smitherman; Alan J Townsend
Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells.
Molecular carcinogenesis 2000;29(3):170-8.
2000: Y Tsuji; H Ayaki; S P Whitman; Charles S Morrow; Suzy V Torti; Frank M Torti
Coordinate transcriptional and translational regulation of ferritin in response to oxidative stress.
Molecular and cellular biology 2000;20(16):5818-27.
1999: SK Diah; Pamela K Smitherman; Alan J Townsend; Charles S Morrow
Detoxification of 1-chloro-2,4-dinitrobenzene in MCF7 breast cancer cells expressing glutathione S-transferase P1-1 and/or multidrug resistance protein 1.
Toxicology and applied pharmacology 1999;157(2):85-93.
1999: Wanda R Fields; Charles S Morrow; Johannes Doehmer; Alan J Townsend
Expression of stably transfected murine glutathione S-transferase A3-3 protects against nucleic acid alkylation and cytotoxicity by aflatoxin B1 in hamster V79 cells expressing rat cytochrome P450-2B1.
Carcinogenesis 1999;20(6):1121-5.
1999: Alan J Townsend; K K Kiningham; D St Clair; T R Tephly; Charles S Morrow; F P Guengerich
Symposium overview: Characterization of xenobiotic metabolizing enzyme function using heterologous expression systems.
Toxicological sciences : an official journal of the Society of Toxicology 1999;48(2):143-50.
1999: Alan J Townsend; Wanda R Fields; AJ Doss; M L Clapper; Johannes Doehmer; Charles S Morrow
Modeling the chemoprotective functions of glutathione S-transferases in cultured cell lines by heterologous expression.
Drug metabolism reviews 1999;31(1):43-69.
1998: Charles S Morrow; Pamela K Smitherman; Alan J Townsend
Combined expression of multidrug resistance protein (MRP) and glutathione S-transferase P1-1 (GSTP1-1) in MCF7 cells and high level resistance to the cytotoxicities of ethacrynic acid but not oxazaphosphorines or cisplatin.
Biochemical pharmacology 1998;56(8):1013-21.
1998: Charles S Morrow; Pamela K Smitherman; SK Diah; E Schneider; Alan J Townsend
Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells.
The Journal of biological chemistry 1998;273(32):20114-20.
1998: Wanda R Fields; Charles S Morrow; AJ Doss; Kathrin Sundberg; Bengt Jernström; Alan J Townsend
Overexpression of stably transfected human glutathione S-transferase P1-1 protects against DNA damage by benzo[a]pyrene diol-epoxide in human T47D cells.
Molecular pharmacology 1998;54(2):298-304.
1998: Alan J Townsend; Wanda R Fields; RL Haynes; AJ Doss; Y Li; Johannes Doehmer; Charles S Morrow
Chemoprotective functions of glutathione S-transferases in cell lines induced to express specific isozymes by stable transfection.
Chemico-biological interactions 1998;111-112():389-407.
1998: MS Jhaveri; Charles S Morrow
Methylation-mediated regulation of the glutathione S-transferase P1 gene in human breast cancer cells.
Gene 1998;210(1):1-7.
1998: MS Jhaveri; Charles S Morrow
Contribution of proximal promoter elements to the regulation of basal and differential glutathione S-transferase P1 gene expression in human breast cancer cells.
Biochimica et biophysica acta 1998;1396(2):179-90.
1998: Charles S Morrow; SK Diah; Pamela K Smitherman; E Schneider; Alan J Townsend
Multidrug resistance protein and glutathione S-transferase P1-1 act in synergy to confer protection from 4-nitroquinoline 1-oxide toxicity.
Carcinogenesis 1998;19(1):109-15.
1997: MS Jhaveri; T E Stephens; Charles S Morrow
Role of posttranscriptional processes in the regulation of glutathione S-transferase P1 gene expression in human breast cancer cells.
Biochemical and biophysical research communications 1997;237(3):729-34.
1994: Charles S Morrow; M Nakagawa; M E Goldsmith; M J Madden; Kenneth H Cowan
Reversible transcriptional activation of mdr1 by sodium butyrate treatment of human colon cancer cells.
The Journal of biological chemistry 1994;269(14):10739-46.
1993: Charles S Morrow; Kenneth H Cowan
Antineoplastic drug resistance and breast cancer.
Annals of the New York Academy of Sciences 1993;698():289-312.
1993: M J Madden; Charles S Morrow; M Nakagawa; M E Goldsmith; C R Fairchild; Kenneth H Cowan
Identification of 5' and 3' sequences involved in the regulation of transcription of the human mdr1 gene in vivo.
The Journal of biological chemistry 1993;268(11):8290-7.
1993: M E Goldsmith; M J Madden; Charles S Morrow; Kenneth H Cowan
A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene.
The Journal of biological chemistry 1993;268(8):5856-60.
1993: Charles S Morrow; Kenneth H Cowan
Drug resistance and cancer.
Advances in experimental medicine and biology 1993;330():287-305.
1992: Charles S Morrow; J Chiu; Kenneth H Cowan
Posttranscriptional control of glutathione S-transferase pi gene expression in human breast cancer cells.
The Journal of biological chemistry 1992;267(15):10544-50.
1992: Jeffrey A Moscow; Charles S Morrow; R He; G T Mullenbach; Kenneth H Cowan
Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1).
The Journal of biological chemistry 1992;267(9):5949-58.
1992: Jeffrey A Moscow; Charles S Morrow; Kenneth H Cowan
Multidrug resistance.
Cancer chemotherapy and biological response modifiers 1992;13():91-114.
1991: Alan J Townsend; Charles S Morrow; B K Sinha; Kenneth H Cowan
Selenium-dependent glutathione peroxidase expression is inversely related to estrogen receptor content of human breast cancer cells.
Cancer communications 1991;3(8):265-70.
1990: Charles S Morrow; Kenneth H Cowan
Multidrug resistance associated with altered topoisomerase II activity--topoisomerases II as targets for rational drug design.
Journal of the National Cancer Institute 1990;82(8):638-9.
1990: Charles S Morrow; M E Goldsmith; Kenneth H Cowan
Regulation of human glutathione S-transferase pi gene transcription: influence of 5'-flanking sequences and trans-activating factors which recognize AP-1-binding sites.
Gene 1990;88(2):215-25.
1990: Charles S Morrow; Kenneth H Cowan
Glutathione S-transferases and drug resistance.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1990;2(1):15-22.
1989: Charles S Morrow; Kenneth H Cowan; M E Goldsmith
Structure of the human genomic glutathione S-transferase-pi gene.
Gene 1989;75(1):3-11.