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Glenn Begley

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C Glenn Begley
Six red flags for suspect work.
Steve Elliott; Paul Kassner; Ian McCaffery; John Rossi; Susan Swift; Leigh Busse; C Glenn Begley
Lack of expression and function of erythropoietin receptors in the kidney.
C Glenn Begley; Lee M Ellis
Drug development: Raise standards for preclinical cancer research.

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All Publications

2013: C Glenn Begley
Six red flags for suspect work.
Nature 2013;497(7450):433-4.
2012: Steve Elliott; Paul Kassner; Ian McCaffery; John Rossi; Susan Swift; Leigh Busse; C Glenn Begley
Lack of expression and function of erythropoietin receptors in the kidney.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012;27(7):2733-45.
2012: C Glenn Begley; Lee M Ellis
Drug development: Raise standards for preclinical cancer research.
Nature 2012;483(7391):531-3.
2010: Susan Swift; Aaron R Ellison; Paul Kassner; Ian McCaffery; John Rossi; Angus M Sinclair; C Glenn Begley; Steven Elliott
Absence of functional EpoR expression in human tumor cell lines.
Blood 2010;115(21):4254-63.
2010: Angus M Sinclair; Angela Coxon; Ian McCaffery; Stephen Kaufman; Katherine Paweletz; Liqin Liu; Leigh Busse; Susan Swift; Steven Elliott; C Glenn Begley
Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells.
Blood 2010;115(21):4264-72.
2010: Barbra J Sasu; Keegan S Cooke; Tara L Arvedson; Cherylene Plewa; Aaron R Ellison; Jackie Sheng; Aaron Winters; Todd Juan; Hongyan Li; C Glenn Begley; Graham Molineux
Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia.
Blood 2010;115(17):3616-24.
2010: Susan E Swift; Steve Elliott; Angus M Sinclair; C Glenn Begley
Erythropoietin receptor in ovarian cancer cells - Letter.
Molecular cancer therapeutics 2010;9(4):1070-1; author reply 1071.
2010: Steve Elliott; Leigh Busse; Ian McCaffery; John Rossi; Angus Sinclair; Chris Spahr; Susan Swift; C Glenn Begley
Identification of a sensitive anti-erythropoietin receptor monoclonal antibody allows detection of low levels of EpoR in cells.
Journal of immunological methods 2010;352(1-2):126-39.
2007: Joachim R Göthert; Rachael L Brake; Monique F M A Smeets; Ulrich Dührsen; C Glenn Begley; David J Izon
NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis.
Blood 2007;110(10):3753-62.
2007: Hayley Ramshaw; Mark A Guthridge; Frank C Stomski; Emma F Barry; Lisa Ooms; Christina A Mitchell; C Glenn Begley; Angel F Lopez
The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis.
Blood 2007;110(10):3582-90.
2007: Hui-Hua Zhang; Sunanda Basu; Fenqiang Wu; C Glenn Begley; Christiaan J M Saris; Ashley R Dunn; Antony W Burgess; Francesca Walker
Macrophage-colony stimulating factor is required for the production of neutrophil-promoting activity by mouse embryo fibroblasts deficient in G-CSF and GM-CSF.
Journal of leukocyte biology 2007;82(4):915-25.
2007: Angus M Sinclair; Marque D Todd; Kevin Forsythe; Susan J Knox; Steve Elliott; C Glenn Begley
Expression and function of erythropoietin receptors in tumors: implications for the use of erythropoiesis-stimulating agents in cancer patients.
Cancer 2007;110(3):477-88.
2007: Cara K Bradley; Elena A Takano; Joachim R Göthert; Berthold Göttgens; Anthony R Green; C Glenn Begley; J Anke M van Eekelen
Temporal regulation of Cre-recombinase activity in Scl-positive neurons of the central nervous system.
Genesis (New York, N.Y. : 2000) 2007;45(3):145-51.
2006: Cara K Bradley; Elena A Takano; Mark A Hall; Joachim R Göthert; Alan R Harvey; C Glenn Begley; J Anke M van Eekelen
The essential haematopoietic transcription factor Scl is also critical for neuronal development.
The European journal of neuroscience 2006;23(7):1677-89.
2006: Steve Elliott; Leigh Busse; Michael B Bass; Hsieng Lu; Ildiko Sarosi; Angus M Sinclair; Chris Spahr; Moonkyoung Um; Gwyneth Van; C Glenn Begley
Anti-Epo receptor antibodies do not predict Epo receptor expression.
Blood 2006;107(5):1892-5.
2006: Mark A Guthridge; Jason A Powell; Emma F Barry; Frank C Stomski; Barbara J McClure; Hayley Ramshaw; Fernando A Felquer; Mara Dottore; Daniel T Thomas; Bik To; C Glenn Begley; Angel F Lopez
Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch.
The EMBO journal 2006;25(3):479-89.
2005: Mark A Hall; Nicholas J Slater; C Glenn Begley; Jessica M Salmon; Leonie J Van Stekelenburg; Matthew P McCormack; Stephen M Jane; David J Curtis
Functional but abnormal adult erythropoiesis in the absence of the stem cell leukemia gene.
Molecular and cellular biology 2005;25(15):6355-62.
2005: Joachim R Göthert; Sonja E Gustin; Mark A Hall; Anthony R Green; Berthold Göttgens; David J Izon; C Glenn Begley
In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis.
Blood 2005;105(7):2724-32.
2005: Barbra J Sasu; Cynthia Hartley; Henry Schultz; Patricia McElroy; Raheemuddin Khaja; Steven Elliott; Joan C Egrie; Jeffrey K Browne; C Glenn Begley; Graham Molineux
Comparison of epoetin alfa and darbepoetin alfa biological activity under different administration schedules in normal mice.
Acta haematologica 2005;113(3):163-74.
2004: Joachim R Göthert; Sonja E Gustin; J Anke M van Eekelen; Uli Schmidt; Mark A Hall; Stephen M Jane; Anthony R Green; Berthold Göttgens; David J Izon; C Glenn Begley
Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium.
Blood 2004;104(6):1769-77.
2004: David J Curtis; Mark A Hall; Leonie J Van Stekelenburg; Lorraine Robb; Stephen M Jane; C Glenn Begley
SCL is required for normal function of short-term repopulating hematopoietic stem cells.
Blood 2004;103(9):3342-8.
2004: Berthold Göttgens; cyril broccardo; Maria-Jose Sanchez; Sophie Deveaux; George Murphy; Joachim R Göthert; Ekaterini Kotsopoulou; Sarah Kinston; Liz Delaney; Sandie Piltz; Linda M Barton; Kathy Knezevic; Wendy N Erber; C Glenn Begley; Jon Frampton; Anthony R Green
The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1.
Molecular and cellular biology 2004;24(5):1870-83.
2004: Rachael L Brake; Paul J Simmons; C Glenn Begley
Cross-contamination with tamoxifen induces transgene expression in non-exposed inducible transgenic mice.
Genetics and molecular research : GMR 2004;3(4):456-62.
2003: Cynthia Hartley; Steve Elliott; C Glenn Begley; Patricia McElroy; Weston Sutherland; Raheem Khaja; Anne C Heatherington; Tom Graves; Henry Schultz; Juan Del Castillo; Graham Molineux
Kinetics of haematopoietic recovery after dose-intensive chemo/radiotherapy in mice: optimized erythroid support with darbepoetin alpha.
British journal of haematology 2003;122(4):623-36.
2003: Dishan H Gunawardana; Russell L Basser; Ian D Davis; Jonathan Cebon; Paul Mitchell; Craig Underhill; Trevor J Kilpatrick; Katrina Reardon; Michael D Green; Peter Bardy; Pene Amor; David Crump; Siobhan Ng; Roger L Nation; C Glenn Begley
A phase I study of recombinant human leukemia inhibitory factor in patients with advanced cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(6):2056-65.
2003: Ann S Wilson; Bridget G Hobbs; Wei-Yong Shen; Terence P Speed; Uli Schmidt; C Glenn Begley; P Elizabeth Rakoczy
Argon laser photocoagulation-induced modification of gene expression in the retina.
Investigative ophthalmology & visual science 2003;44(4):1426-34.
2003: Mark A Hall; David J Curtis; Donald Metcalf; Andrew G Elefanty; Koula Sourris; Lorraine Robb; Joachim R Gothert; Stephen M Jane; C Glenn Begley
The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):992-7.
2003: Uli Schmidt; C Glenn Begley
Cancer diagnosis and microarrays.
The international journal of biochemistry & cell biology 2003;35(2):119-24.
2003: J Anke M van Eekelen; Cara K Bradley; Joachim R Göthert; L Robb; A G Elefanty; C Glenn Begley; Alan R Harvey
Expression pattern of the stem cell leukaemia gene in the CNS of the embryonic and adult mouse.
Neuroscience 2003;122(2):421-36.
2002: David J Kuter; C Glenn Begley
Recombinant human thrombopoietin: basic biology and evaluation of clinical studies.
Blood 2002;100(10):3457-69.
2002: Eric Lécuyer; Sabine Herblot; Marianne Saint-Denis; Richard Martin; C Glenn Begley; Catherine Porcher; Stuart H Orkin; Trang Hoang
The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1.
Blood 2002;100(7):2430-40.
2002: Anne T Reutens; C Glenn Begley
Endophilin-1: a multifunctional protein.
The international journal of biochemistry & cell biology 2002;34(10):1173-7.
2002: E O'Flaherty; W Cook; J Boyd; Susan L Grant; J Kurek; C Glenn Begley
Cytotoxicity of paclitaxel or cisplatin on carcinoma cell lines is not inhibited by leukemia inhibitory factor (LIF).
Growth factors (Chur, Switzerland) 2002;20(3):141-5.
2002: Emma Smith; Murray Hargrave; Toshiya Yamada; C Glenn Begley; Melissa H Little
Coexpression of SCL and GATA3 in the V2 interneurons of the developing mouse spinal cord.
Developmental dynamics : an official publication of the American Association of Anatomists 2002;224(2):231-7.
2002: Russell L Basser; Elizabeth O'Flaherty; Michael Green; Maria Edmonds; Janet Nichol; Dora M Menchaca; Brian Cohen; C Glenn Begley
Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor.
Blood 2002;99(7):2599-602.
2002: Susan L Grant; Annet Hammacher; Andrea M Douglas; Geraldine A Goss; Rachel K Mansfield; John Heath; C Glenn Begley
An unexpected biochemical and functional interaction between gp130 and the EGF receptor family in breast cancer cells.
Oncogene 2002;21(3):460-74.
2001: Clare L Scott; Lorraine Robb; Harshal H Nandurkar; R Mansfield; Warren S Alexander; C Glenn Begley
Thrombopoietin signaling is required for in vivo expansion of IL-11--responsive hematopoietic progenitor cells in the steady state.
Experimental hematology 2001;29(2):138-45.
2001: Susan L Grant; Andrea M Douglas; Geraldine A Goss; C Glenn Begley
Oncostatin M and leukemia inhibitory factor regulate the growth of normal human breast epithelial cells.
Growth factors (Chur, Switzerland) 2001;19(3):153-62.
2001: Russell L Basser; C Glenn Begley
Thrombopoietin.
Cancer investigation 2001;19(6):660-6.
2000: Lorraine Robb; Lynne Hartley; C Glenn Begley; Thomas C Brodnicki; NG Copeland; DJ Gilbert; NA Jenkins; Andrew G Elefanty
Cloning, expression analysis, and chromosomal localization of murine and human homologues of a Xenopus mix gene.
Developmental dynamics : an official publication of the American Association of Anatomists 2000;219(4):497-504.
2000: David J Curtis; Stephen M Jane; Douglas J Hilton; L Dougherty; David M Bodine; C Glenn Begley
Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest.
Experimental hematology 2000;28(11):1250-9.
2000: Clare L Scott; Lorraine Robb; R Mansfield; Warren S Alexander; C Glenn Begley
Granulocyte-macrophage colony-stimulating factor is not responsible for residual thrombopoiesis in mpl null mice.
Experimental hematology 2000;28(9):1001-7.
2000: Clare L Scott; Lorraine Robb; B Papaevangeliou; R Mansfield; Nicos A Nicola; C Glenn Begley
Reassessment of interactions between hematopoietic receptors using common beta-chain and interleukin-3-specific receptor beta-chain-null cells: no evidence of functional interactions with receptors for erythropoietin, granulocyte colony-stimulating factor, or stem cell factor.
Blood 2000;96(4):1588-90.
2000: Clare L Scott; L Roe; Joan Curtis; Tracey M Baldwin; Lorraine Robb; C Glenn Begley; Emanuela Handman
Mice unresponsive to GM-CSF are unexpectedly resistant to cutaneous Leishmania major infection.
Microbes and infection / Institut Pasteur 2000;2(10):1131-8.
2000: Russell L Basser; Craig Underhill; I Davis; Michael D Green; Jonathan Cebon; John Zalcberg; J MacMillan; Brian Cohen; J Marty; Richard M Fox; C Glenn Begley
Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(15):2852-61.
2000: C Glenn Begley; Russell L Basser
Biologic and structural differences of thrombopoietic growth factors.
Seminars in hematology 2000;37(2 Suppl 4):19-27.
2000: T Gainsford; Harshal H Nandurkar; Donald Metcalf; Lorraine Robb; C Glenn Begley; Warren S Alexander
The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor.
Blood 2000;95(2):528-34.
2000: David J Curtis; Donald Metcalf; B Alexander; C Glenn Begley
Leukemic cells from murine myeloid leukemia display an intrinsic ability for autonomous proliferation.
Experimental hematology 2000;28(1):36-45.
1999: Andrew G Elefanty; C Glenn Begley; Lynne Hartley; B Papaevangeliou; Lorraine Robb
SCL expression in the mouse embryo detected with a targeted lacZ reporter gene demonstrates its localization to hematopoietic, vascular, and neural tissues.
Blood 1999;94(11):3754-63.
1999: C L Scott; C Glenn Begley
The beta common chain (beta c) of the granulocyte macrophage-colony stimulating factor, interleukin-3 and interleukin-5 receptors.
The international journal of biochemistry & cell biology 1999;31(10):1011-5.
1999: Susan L Grant; C Glenn Begley
The oncostatin M signalling pathway: reversing the neoplastic phenotype?
Molecular medicine today 1999;5(9):406-12.
1999: M Sánchez; Berthold Göttgens; Angus M Sinclair; M Stanley; C Glenn Begley; S Hunter; Anthony R Green
An SCL 3' enhancer targets developing endothelium together with embryonic and adult haematopoietic progenitors.
Development (Cambridge, England) 1999;126(17):3891-904.
1999: C Glenn Begley; A R Green
The SCL gene: from case report to critical hematopoietic regulator.
Blood 1999;93(9):2760-70.
1999: C Glenn Begley; Nicos A Nicola
Resolving conflicting signals: cross inhibition of cytokine signaling pathways.
Blood 1999;93(5):1443-7.
1999: Russell L Basser; L Bik To; J P Collins; C Glenn Begley; dorothy Keefe; Jonathan Cebon; John Bashford; Simon Durrant; Jeff Szer; D Kotasek; CA Juttner; I Russell; Darryl W Maher; Ian N Olver; William Patrick Sheridan; Richard M Fox; Michael D Green
Multicycle high-dose chemotherapy and filgrastim-mobilized peripheral-blood progenitor cells in women with high-risk stage II or III breast cancer: five-year follow-up.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(1):82-92.
1998: Clare L Scott; derralynn hughes; Dale Cary; Nicos A Nicola; C Glenn Begley; Lorraine Robb
Functional analysis of mature hematopoietic cells from mice lacking the betac chain of the granulocyte-macrophage colony-stimulating factor receptor.
Blood 1998;92(11):4119-27.
1998: Andrew G Elefanty; C Glenn Begley; Donald Metcalf; Louise Barnett; F Köntgen; Lorraine Robb
Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ "knock-in" strategy.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11897-902.
1998: Lorraine Robb; Lynne Hartley; CC Wang; Richard P Harvey; C Glenn Begley
musculin: a murine basic helix-loop-helix transcription factor gene expressed in embryonic skeletal muscle.
Mechanisms of development 1998;76(1-2):197-201.
1998: John Rasko; C Glenn Begley
The thrombopoietic factor, Mpl-ligand.
The international journal of biochemistry & cell biology 1998;30(6):657-60.
1998: Russell L Basser; L Bik To; C Glenn Begley; D Maher; CA Juttner; Jonathan Cebon; R Mansfield; Ian N Olver; G Duggan; Jeff Szer; J Collins; B Schwartz; J Marty; Dora M Menchaca; William Patrick Sheridan; Richard M Fox; Michael D Green
Rapid hematopoietic recovery after multicycle high-dose chemotherapy: enhancement of filgrastim-induced progenitor-cell mobilization by recombinant human stem-cell factor.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(5):1899-908.
1998: T Gainsford; A W Roberts; S Kimura; Donald Metcalf; Glenn Dranoff; R C Mulligan; C Glenn Begley; Lorraine Robb; Warren S Alexander
Cytokine production and function in c-mpl-deficient mice: no physiologic role for interleukin-3 in residual megakaryocyte and platelet production.
Blood 1998;91(8):2745-52.
1998: Warren S Alexander; C Glenn Begley
Thrombopoietin in vitro and in vivo.
Cytokines, cellular & molecular therapy 1998;4(1):25-34.
1998: Lorraine Robb; R Li; L Hartley; Harshal H Nandurkar; Frank Koentgen; C Glenn Begley
Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation.
Nature medicine 1998;4(3):303-8.
1998: Andrea M Douglas; Susan L Grant; Geraldine A Goss; David R Clouston; R L Sutherland; C Glenn Begley
Oncostatin M induces the differentiation of breast cancer cells.
International journal of cancer. Journal international du cancer 1998;75(1):64-73.
1998: Harshal H Nandurkar; Lorraine Robb; C Glenn Begley
The role of IL-II in hematopoiesis as revealed by a targeted mutation of its receptor.
Stem cells (Dayton, Ohio) 1998;16 Suppl 2():53-65.
1997: David J Curtis; Lorraine Robb; Andreas Strasser; C Glenn Begley
The CD2-scl transgene alters the phenotype and frequency of T-lymphomas in N-ras transgenic or p53 deficient mice.
Oncogene 1997;15(24):2975-83.
1997: D J Curtis; Douglas J Hilton; B Roberts; L Murray; Nicos A Nicola; C Glenn Begley
Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonist.
Blood 1997;90(11):4403-12.
1997: Berthold Göttgens; F McLaughlin; EO Bockamp; JL Fordham; C Glenn Begley; K Kosmopoulos; Andrew G Elefanty; Anthony R Green
Transcription of the SCL gene in erythroid and CD34 positive primitive myeloid cells is controlled by a complex network of lineage-restricted chromatin-dependent and chromatin-independent regulatory elements.
Oncogene 1997;15(20):2419-28.
1997: C Glenn Begley; Russell L Basser; R Mansfield; B Thomson; W R Parker; JE Layton; Bik To; Jonathan Cebon; William Patrick Sheridan; Richard M Fox; Michael D Green
Enhanced levels and enhanced clonogenic capacity of blood progenitor cells following administration of stem cell factor plus granulocyte colony-stimulating factor to humans.
Blood 1997;90(9):3378-89.
1997: Harshal H Nandurkar; Lorraine Robb; David M Tarlinton; Louise Barnett; F Köntgen; C Glenn Begley
Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis.
Blood 1997;90(6):2148-59.
1997: Andrew G Elefanty; Lorraine Robb; R Birner; C Glenn Begley
Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells.
Blood 1997;90(4):1435-47.
1997: Lorraine Robb; C Glenn Begley
The SCL/TAL1 gene: roles in normal and malignant haematopoiesis.
BioEssays : news and reviews in molecular, cellular and developmental biology 1997;19(7):607-13.
1997: C Glenn Begley
Clinical studies with megakaryocyte growth and development factor (Mpl-ligand).
Thrombosis and haemostasis 1997;78(1):42-6.
1997: John Rasko; Russell L Basser; J Boyd; R Mansfield; C J O'Malley; S Hussein; M C Berndt; K Clarke; J O'Byrne; William Patrick Sheridan; Andrew P Grigg; C Glenn Begley
Multilineage mobilization of peripheral blood progenitor cells in humans following administration of PEG-rHuMGDF.
British journal of haematology 1997;97(4):871-80.
1997: Harshal H Nandurkar; Lorraine Robb; J K Nicholl; Douglas J Hilton; G R Sutherland; C Glenn Begley
The gene for the human interleukin-11 receptor alpha chain locus is highly homologous to the murine gene and contains alternatively spliced first exons.
The international journal of biochemistry & cell biology 1997;29(5):753-66.
1997: John Rasko; Donald Metcalf; B Alexander; Andreas Strasser; C Glenn Begley
Establishment of multipotential and antigen presenting cell lines derived from myeloid leukemias in GM-CSF transgenic mice.
Leukemia 1997;11(5):732-42.
1997: Russell L Basser; John Rasko; K Clarke; Jonathan Cebon; Michael D Green; Andrew P Grigg; John Zalcberg; Brian Cohen; J O'Byrne; Dora M Menchaca; Richard M Fox; C Glenn Begley
Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer.
Blood 1997;89(9):3118-28.
1997: Lorraine Robb; Douglas J Hilton; P T Brook-Carter; C Glenn Begley
Identification of a second murine interleukin-11 receptor alpha-chain gene (IL11Ra2) with a restricted pattern of expression.
Genomics 1997;40(3):387-94.
1997: Andrea M Douglas; Geraldine A Goss; R L Sutherland; D J Hilton; M C Berndt; N A Nicola; C Glenn Begley
Expression and function of members of the cytokine receptor superfamily on breast cancer cells.
Oncogene 1997;14(6):661-9.
1997: Nicos A Nicola; A Smith; Lorraine Robb; Donald Metcalf; C Glenn Begley
The structural basis of the biological actions of the GM-CSF receptor.
Ciba Foundation symposium 1997;204():19-27; discussion 27-32.
1997: John Rasko; E O'Flaherty; C Glenn Begley
Mpl ligand (MGDF) alone and in combination with stem cell factor (SCF) promotes proliferation and survival of human megakaryocyte, erythroid and granulocyte/macrophage progenitors.
Stem cells (Dayton, Ohio) 1997;15(1):33-42.
1996: Russell L Basser; John Rasko; K Clarke; Jonathan Cebon; Michael D Green; S Hussein; C Alt; Dora M Menchaca; Dianne Tomita; J Marty; Richard M Fox; C Glenn Begley
Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer.
Lancet 1996;348(9037):1279-81.
1996: C J O'Malley; John Rasko; Russell L Basser; K M McGrath; Jonathan Cebon; A P Grigg; W Hopkins; B Cohen; J O'Byrne; Michael D Green; Richard M Fox; M C Berndt; C Glenn Begley
Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation.
Blood 1996;88(9):3288-98.
1996: Lorraine Robb; N J Elwood; Andrew G Elefanty; F Köntgen; R Li; Louise Barnett; C Glenn Begley
The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.
The EMBO journal 1996;15(16):4123-9.
1996: C Glenn Begley; John Rasko; D Curtis; K Takagi; Donald Metcalf; D Hilton; B Roberts; Nicos A Nicola; M T Rossner
Murine flt3 ligand protects M1 leukemic cells from LIF-induced differentiation and suppression of self-renewal.
Experimental hematology 1996;24(10):1247-57.
1996: Lorraine Robb; Douglas J Hilton; Tracy A Willson; C Glenn Begley
Structural analysis of the gene encoding the murine interleukin-11 receptor alpha-chain and a related locus.
The Journal of biological chemistry 1996;271(23):13754-61.
1996: Lorraine Robb; C Glenn Begley
The helix-loop-helix gene SCL: implicated in T-cell acute lymphoblastic leukaemia and in normal haematopoietic development.
The international journal of biochemistry & cell biology 1996;28(6):609-18.
1996: Nicos A Nicola; Lorraine Robb; Donald Metcalf; Dale Cary; C C Drinkwater; C Glenn Begley
Functional inactivation in mice of the gene for the interleukin-3 (IL-3)-specific receptor beta-chain: implications for IL-3 function and the mechanism of receptor transmodulation in hematopoietic cells.
Blood 1996;87(7):2665-74.
1996: Catherine M Owczarek; M J Layton; Lorraine Robb; Nicos A Nicola; C Glenn Begley
Molecular basis of the soluble and membrane-bound forms of the murine leukemia inhibitory factor receptor alpha-chain. Expression in normal, gestating, and leukemia inhibitory factor nullizygous mice.
The Journal of biological chemistry 1996;271(10):5495-504.
1996: Harshal H Nandurkar; Douglas J Hilton; P Nathan; Tracy A Willson; Nicos A Nicola; C Glenn Begley
The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor.
Oncogene 1996;12(3):585-93.
1995: John Rasko; Donald Metcalf; M T Rossner; C Glenn Begley; Nicos A Nicola
The flt3/flk-2 ligand: receptor distribution and action on murine haemopoietic cell survival and proliferation.
Leukemia 1995;9(12):2058-66.
1995: Lorraine Robb; C C Drinkwater; Donald Metcalf; R Li; F Köntgen; Nicos A Nicola; C Glenn Begley
Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9565-9.
1995: Andrew W Roberts; C Glenn Begley; A P Grigg; Russell L Basser
Do steady-state peripheral blood progenitor cell (PBPC) counts predict the yield of PBPC mobilized by filgrastim alone?
Blood 1995;86(6):2451.
1995: Andrew W Roberts; E DeLuca; C Glenn Begley; Russell L Basser; A P Grigg; Donald Metcalf
Broad inter-individual variations in circulating progenitor cell numbers induced by granulocyte colony-stimulating factor therapy.
Stem cells (Dayton, Ohio) 1995;13(5):512-6.
1995: EO Bockamp; F McLaughlin; A M Murrell; Berthold Göttgens; Lorraine Robb; C Glenn Begley; Anthony R Green
Lineage-restricted regulation of the murine SCL/TAL-1 promoter.
Blood 1995;86(4):1502-14.
1995: Lorraine Robb; I Lyons; R Li; Lynne Hartley; F Köntgen; Richard P Harvey; Donald Metcalf; C Glenn Begley
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):7075-9.
1995: Russell L Basser; L Bik To; C Glenn Begley; C A Juttner; Darryl W Maher; Jeff Szer; Jonathan Cebon; J P Collins; I Russell; Ian N Olver
Adjuvant treatment of high-risk breast cancer using multicycle high-dose chemotherapy and filgrastim-mobilized peripheral blood progenitor cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(7):715-21.
1995: John Rasko; Donald Metcalf; N M Gough; C Glenn Begley
The cytokine receptor repertoire specifies autocrine growth factor production in factor-dependent cells.
Experimental hematology 1995;23(5):453-60.
1995: T Tanigawa; Nicos A Nicola; G A McArthur; Andreas Strasser; C Glenn Begley
Differential regulation of macrophage differentiation in response to leukemia inhibitory factor/oncostatin-M/interleukin-6: the effect of enforced expression of the SCL transcription factor.
Blood 1995;85(2):379-90.
1995: L Robb; John Rasko; Mary L Bath; Andreas Strasser; C Glenn Begley
scl, a gene frequently activated in human T cell leukaemia, does not induce lymphomas in transgenic mice.
Oncogene 1995;10(1):205-9.
1995: N J Elwood; C Glenn Begley
Reconstitution of mice with bone marrow cells expressing the SCL gene is insufficient to cause leukemia.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(1):19-25.
1994: Douglas J Hilton; A A Hilton; A Raicevic; Steven Rakar; M Harrison-Smith; N M Gough; C Glenn Begley; Donald Metcalf; Nicos A Nicola; Tracy A Willson
Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.
The EMBO journal 1994;13(20):4765-75.
1994: M A Brown; M Harrison-Smith; E DeLuca; C Glenn Begley; N M Gough
No evidence for GM-CSF receptor alpha chain gene mutation in AML-M2 leukemias which have lost a sex chromosome.
Leukemia 1994;8(10):1774-9.
1994: J D Lickliter; C Glenn Begley; Andrew W Boyd; Jeff Szer; A P Grigg
Combined chemotherapy and granulocyte colony-stimulating factor (G-CSF) mobilise large numbers of peripheral blood progenitor cells in pretreated patients.
Leukemia & lymphoma 1994;15(1-2):91-7.
1994: R G Doig; C Glenn Begley; K M McGrath
Hereditary protein C deficiency associated with mutations in exon IX of the protein C gene.
Thrombosis and haemostasis 1994;72(2):203-8.
1994: I Busmanis; F Feleppa; A Jones; K M McGrath; R Reed; J Collins; I Russell; C Glenn Begley
Analysis of cerbB2 expression using a panel of 6 commercially available antibodies.
Pathology 1994;26(3):261-7.
1994: William Patrick Sheridan; C Glenn Begley; L B To; A Grigg; Jeff Szer; D Maher; Michael D Green; P A Rowlings; K M McGrath; Jonathan Cebon
Phase II study of autologous filgrastim (G-CSF)-mobilized peripheral blood progenitor cells to restore hemopoiesis after high-dose chemotherapy for lymphoid malignancies.
Bone marrow transplantation 1994;14(1):105-11.
1994: T Tanigawa; Lorraine Robb; Anthony R Green; C Glenn Begley
Constitutive expression of the putative transcription factor SCL associated with proviral insertion in the myeloid leukemic cell line WEHI-3BD-.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(6):557-61.
1994: Lorraine Robb; S Rockman; C Glenn Begley; A W Boyd; K McGrath
A study of granular lymphoproliferative disorders including a CD3 negative case with a rearrangement of the T-cell receptor locus.
Leukemia & lymphoma 1994;13(1-2):143-50.
1994: C Glenn Begley; Lorraine Robb; S Rockman; J Visvader; EO Bockamp; Y S Chan; Anthony R Green
Structure of the gene encoding the murine SCL protein.
Gene 1994;138(1-2):93-9.
1994: N J Elwood; Anthony R Green; A Melder; C Glenn Begley; Nicos A Nicola
The SCL protein displays cell-specific heterogeneity in size.
Leukemia 1994;8(1):106-14.
1994: C Glenn Begley
The SCL transcription factor and differential regulation of macrophage differentiation by LIF, OSM and IL-6.
Stem cells (Dayton, Ohio) 1994;12 Suppl 1():143-9; discussion 149-51.
1993: N J Elwood; W D Cook; Donald Metcalf; C Glenn Begley
SCL, the gene implicated in human T-cell leukaemia, is oncogenic in a murine T-lymphocyte cell line.
Oncogene 1993;8(11):3093-101.
1993: Jack Metz; K M McGrath; H F Savoia; C Glenn Begley; R Chetty
T cell lymphoid aggregates in bone marrow in idiopathic hypereosinophilic syndrome.
Journal of clinical pathology 1993;46(10):955-8.
1993: T Tanigawa; N Elwood; Donald Metcalf; Dale Cary; E DeLuca; Nicos A Nicola; C Glenn Begley
The SCL gene product is regulated by and differentially regulates cytokine responses during myeloid leukemic cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7864-8.
1993: Anthony R Green; S Rockman; E DeLuca; C Glenn Begley
Induced myeloid differentiation of K562 cells with downregulation of erythroid and megakaryocytic transcription factors: a novel experimental model for hemopoietic lineage restriction.
Experimental hematology 1993;21(4):525-31.
1993: M A Brown; N M Gough; Tracy A Willson; S Rockman; C Glenn Begley
Structure and expression of the GM-CSF receptor alpha and beta chain genes in human leukemia.
Leukemia 1993;7(1):63-74.
1993: A Grigg; C Glenn Begley; C A Juttner; Jeff Szer; L B To; D Maher; K M McGrath; G Morstyn; Richard M Fox; William Patrick Sheridan
Effect of peripheral blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy.
Bone marrow transplantation 1993;11 Suppl 2():23-9.
1993: I Busmanis; S Hussein; F Feleppa; S Rockman; C Glenn Begley
B cell chronic lymphocytic leukemia with florid reactive CD4+ T cell lymphocytosis in lymph nodes.
Leukemia & lymphoma 1993;9(1-2):153-6.
1992: E DeLuca; William Patrick Sheridan; D Watson; J Szer; C Glenn Begley
Prior chemotherapy does not prevent effective mobilisation by G-CSF of peripheral blood progenitor cells.
British journal of cancer 1992;66(5):893-9.
1992: Anthony R Green; C Glenn Begley
SCL and related hemopoietic helix-loop-helix transcription factors.
International journal of cell cloning 1992;10(5):269-76.
1992: S Rockman; C Glenn Begley; G Kannourakis; Graham J Mann; Alexander Dobrovic; R F Kefford; K McGrath
SCL gene in human tumors.
Leukemia 1992;6(7):623-5.
1992: F M Cicuttini; M Martin; E Salvaris; L Ashman; C Glenn Begley; J Novotny; D Maher; A W Boyd
Support of human cord blood progenitor cells on human stromal cell lines transformed by SV40 large T antigen under the influence of an inducible (metallothionein) promoter.
Blood 1992;80(1):102-12.
1992: William Patrick Sheridan; C Glenn Begley; C A Juttner; Jeff Szer; L B To; D Maher; K M McGrath; G Morstyn; Richard M Fox
Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy.
Lancet 1992;339(8794):640-4.
1992: C Glenn Begley; Stan Lipkowitz; V Göbel; Kathleen A Mahon; VL Bertness; Anthony R Green; N M Gough; Ilan R Kirsch
Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):38-42.
1992: N M Gough; Stan Lipkowitz; Ilan R Kirsch; C Glenn Begley
Localization of murine HLH gene NSCL to chromosome 1 by use of recombinant inbred strains.
Mammalian genome : official journal of the International Mammalian Genome Society 1992;3(3):182-3.
1992: F M Cicuttini; C Glenn Begley; A W Boyd
The effect of recombinant stem cell factor (SCF) on purified CD34-positive human umbilical cord blood progenitor cells.
Growth factors (Chur, Switzerland) 1992;6(1):31-9.
1992: C Glenn Begley; E DeLuca; P A Rowlings; J Szer; D Watson; CA Juttner; G Morstyn; R M Fox; William Patrick Sheridan
G-CSF mobilised progenitor cells in autologous transplantation: in vitro and in vivo aspects.
Journal of nutritional science and vitaminology 1992;Spec No():368-71.
1991: Anthony R Green; E DeLuca; C Glenn Begley
Antisense SCL suppresses self-renewal and enhances spontaneous erythroid differentiation of the human leukaemic cell line K562.
The EMBO journal 1991;10(13):4153-8.
1991: J Visvader; C Glenn Begley
Helix-loop-helix genes translocated in lymphoid leukemia.
Trends in biochemical sciences 1991;16(9):330-3.
1991: Anthony R Green; E Salvaris; C Glenn Begley
Erythroid expression of the 'helix-loop-helix' gene, SCL.
Oncogene 1991;6(3):475-9.
1991: J Visvader; C Glenn Begley; Jerry M Adams
Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system.
Oncogene 1991;6(2):187-94.
1991: C Glenn Begley; J Visvader; Anthony R Green; Peter D Aplan; Donald Metcalf; Ilan R Kirsch; N M Gough
Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):869-73.
1990: Peter D Aplan; C Glenn Begley; VL Bertness; M Nussmeier; A Ezquerra; J Coligan; Ilan R Kirsch
The SCL gene is formed from a transcriptionally complex locus.
Molecular and cellular biology 1990;10(12):6426-35.
1990: Carolyn A Felix; David G Poplack; Gregory H Reaman; Seth M Steinberg; D E Cole; B J Taylor; C Glenn Begley; Ilan R Kirsch
Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(3):431-42.
1990: C Glenn Begley; J D Burton; M Tsudo; B H Brownstein; J L Ambrus; Thomas Waldmann
Human B lymphocytes express the p75 component of the interleukin 2 receptor.
Leukemia research 1990;14(3):263-71.
1989: Jeffrey E Green; C Glenn Begley; D K Wagner; Thomas Waldmann; G Jay
trans activation of granulocyte-macrophage colony-stimulating factor and the interleukin-2 receptor in transgenic mice carrying the human T-lymphotropic virus type 1 tax gene.
Molecular and cellular biology 1989;9(11):4731-7.
1989: C Glenn Begley; Peter D Aplan; Michael P Davey; Jean-Pierre De Villartay; D I Cohen; Thomas Waldmann; Ilan R Kirsch
Demonstration of delta rec-pseudo J alpha rearrangement with deletion of the delta locus in a human stem-cell leukemia.
The Journal of experimental medicine 1989;170(1):339-42.
1989: C Glenn Begley; Peter D Aplan; Michael P Davey; K Nakahara; K Tchorz; Joanne Kurtzberg; Michael S Hershfield; Barton F Haynes; D I Cohen; Thomas Waldmann
Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(6):2031-5.
1988: G Kannourakis; G R Johnson; C Glenn Begley; J A Werkmeister; Gordon F Burns
Enhancement of in vitro beta-thalassemic and normal hematopoiesis by a noncytotoxic monoclonal antibody, 9.1C3: evidence for negative regulation of hematopoiesis by monocytes and natural killer cells.
Blood 1988;72(4):1124-33.
1988: A W Boyd; D W Ellis; G Kannourakis; C Glenn Begley; I R Mackay; G F Burns
Activated killer cell lymphoma: an erythrophagocytic syndrome simulating histiocytic medullary histiocytosis.
Pathology 1988;20(3):265-70.
1988: G Kannourakis; C Glenn Begley; G R Johnson; J A Werkmeister; Gordon F Burns
Evidence for interactions between monocytes and natural killer cells in the regulation of in vitro hemopoiesis.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(8):2489-94.
1988: D J Williamson; C Glenn Begley; M A Vadas; Donald Metcalf
The detection and initial characterization of colony-stimulating factors in synovial fluid.
Clinical and experimental immunology 1988;72(1):67-73.
1988: C Glenn Begley; Nicos A Nicola; Donald Metcalf
Proliferation of normal human promyelocytes and myelocytes after a single pulse stimulation by purified GM-CSF or G-CSF.
Blood 1988;71(3):640-5.
1988: C Glenn Begley; Donald Metcalf; Nicos A Nicola
Binding characteristics and proliferative action of purified granulocyte colony-stimulating factor (G-CSF) on normal and leukemic human promyelocytes.
Experimental hematology 1988;16(1):71-9.
1987: D J Williamson; C Glenn Begley
Colony-stimulating factors in the pathogenesis and treatment of disease.
Postgraduate medical journal 1987;63(746):1061-8.
1987: C Glenn Begley; B Tait; R M Crapper; P G Briggs; G N Brodie; I R Mackay
Familial hairy cell leukemia.
Leukemia research 1987;11(11):1027-9.
1987: C Glenn Begley; Donald Metcalf; Nicos A Nicola
Primary human myeloid leukemia cells: comparative responsiveness to proliferative stimulation by GM-CSF or G-CSF and membrane expression of CSF receptors.
Leukemia 1987;1(1):1-8.