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John Morser

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Mohammad A Khan; Sven Klussmann; Lawrence L Leung; Christian Maasch; John Morser; Carl Atkinson; Peter S Heeger; Stephen Tomlinson; Axel Vater; Mark R Nicolls
Targeting complement component 5a promotes vascular integrity and limits airway remodeling.
Mikael Evander; Gregory T A Kovacs; Lawrence L K Leung; John Morser; Antonio J Ricco; Laurent Giovangrandi
Microfluidic impedance cytometer for platelet analysis.
Yasuto Yamaguchi; Xiao-Yan Du; Michael Glantz; Griffith Harsh; Milton Merchant; John Morser; Timothy Myles; Lawrence Recht; Zhifei Shao; Shadi Sharif; Lawrence L K Leung
Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage.

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All Publications

2013: Mohammad A Khan; Sven Klussmann; Lawrence L Leung; Christian Maasch; John Morser; Carl Atkinson; Peter S Heeger; Stephen Tomlinson; Axel Vater; Mark R Nicolls
Targeting complement component 5a promotes vascular integrity and limits airway remodeling.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(15):6061-6.
2013: Mikael Evander; Gregory T A Kovacs; Lawrence L K Leung; John Morser; Antonio J Ricco; Laurent Giovangrandi
Microfluidic impedance cytometer for platelet analysis.
Lab on a chip 2013;13(4):722-9.
2013: Yasuto Yamaguchi; Xiao-Yan Du; Michael Glantz; Griffith Harsh; Milton Merchant; John Morser; Timothy Myles; Lawrence Recht; Zhifei Shao; Shadi Sharif; Lawrence L K Leung
Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage.
The Journal of biological chemistry 2013;288(5):3097-111.
2013: Daniel Boveda-Ruiz; Ayshwarya-Lakshmi Chelakkot-Govindalayathil; Corina N D'Alessandro-Gabazza; Paloma Gil-Bernabe; Tetsu Kobayashi; Takahiro Matsumoto; Yuki Matsushima; Yasushi Miyake; John Morser; Masahiro Naito; Osamu Taguchi; Takehiro Takagi; Masaaki Toda; Atsushi Yasukawa; Esteban C Gabazza
Differential role of regulatory T cells in early and late stages of pulmonary fibrosis.
Immunobiology 2013;218(2):245-54.
2012: Atsushi Fujiwara; Daniel Boveda-Ruiz; Corina N D'Alessandro-Gabazza; Paloma Gil-Bernabe; Hiroyasu Kobayashi; Tetsu Kobayashi; Yuki Matsushima; Yasushi Miyake; John Morser; Masahiro Naito; Osamu Taguchi; Takehiro Takagi; Yoshiyuki Takei; Masaaki Toda; Atsushi Yasukawa; Masamichi Yoshida; Esteban C Gabazza
Role of thrombin-activatable fibrinolysis inhibitor in allergic bronchial asthma.
Lung 2012;190(2):189-98.
2012: P Gil-Bernabe; Y Miyake; John Morser; Y Onishi; T Suzuki; Yoshiyuki Takei; M Toda; D Boveda Ruiz; Corina N D'Alessandro-Gabazza; Esteban C Gabazza; Yutaka Yano
Exogenous activated protein C inhibits the progression of diabetic nephropathy.
Journal of thrombosis and haemostasis : JTH 2012;10(3):337-46.
2012: John Morser
Thrombomodulin links coagulation to inflammation and immunity.
Current drug targets 2012;13(3):421-31.
2012: Corina N D'Alessandro-Gabazza; Ayako Fukuda; Daniel Boveda-Ruiz; Paloma Gil-Bernabe; Tetsuya Hasegawa; Tetsu Kobayashi; Yoshikazu Matsuda; Yasushi Miyake; John Morser; Stephen I Rennard; Hiromitsu Saito; Noboru Suzuki; Osamu Taguchi; Takehiro Takagi; Yoshiyuki Takei; Masaaki Toda; Hidekazu Toyobuku; Peter D Wagner; Yutaka Yano; Atsushi Yasukawa; Esteban C Gabazza
Development and preclinical efficacy of novel transforming growth factor-β1 short interfering RNAs for pulmonary fibrosis.
American journal of respiratory cell and molecular biology 2012;46(3):397-406.
2012: Tomohiro Hamasaki; Hirotake Hayashi; Tetsu Kobayashi; Masahiko Kuroda; Takahiro Matsumoto; Takayuki Mizutani; John Morser; Masahiro Naito; Takahiro Ochiya; Daniel Boveda-Ruiz; Corina N D'Alessandro-Gabazza; Yutaka Eguchi; Esteban C Gabazza; Paloma Gil-Bernabe; Hisao Shirohzu; Hiroshi Suzuki; Osamu Taguchi; Masaaki Toda; Tadaaki Ohgi
Efficacy of a novel class of RNA interference therapeutic agents.
PloS one 2012;7(8):e42655.
2011: Yasuto Yamaguchi; Lei Zhao; Xiao-Yan Du; John Morser; Lawrence L K Leung
Proteolytic cleavage of chemerin protein is necessary for activation to the active form, Chem157S, which functions as a signaling molecule in glioblastoma.
The Journal of biological chemistry 2011;286(45):39510-9.
2011: Lei Zhao; Xiao-Yan Du; David M Lee; John Morser; Lawrence D Recht; William H Robinson; Shadi Sharif; Jason J Song; Yasuto Yamaguchi; Lawrence L K Leung
Chemerin158K protein is the dominant chemerin isoform in synovial and cerebrospinal fluids but not in plasma.
The Journal of biological chemistry 2011;286(45):39520-7.
2011: Jason J Song; Tiffany H Wang; Lei Zhao; S Louis Bridges; Kyung H Cho; Michael A Garcia; Stuart B Goodman; Peter K Gregersen; Inyong Hwang; Arthur J Kim; Annette T Lee; David M Lee; Lawrence L Leung; Tamsin M Lindstrom; John Morser; Michael Nesheim; Toshihiko Nishimura; William H Robinson
Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis.
The Journal of clinical investigation 2011;121(9):3517-27.
2011: Paloma Gil-Bernabe; Motoh Iwasa; Rumi Mifuji-Moroka; Yasushi Miyake; John Morser; Daniel Boveda-Ruiz; Corina N D'Alessandro-Gabazza; Esteban C Gabazza; Masaaki Toda; Yoshiyuki Takei
Atherosclerosis amelioration by moderate alcohol consumption is associated with increased circulating levels of stromal cell-derived factor-1.
Circulation journal : official journal of the Japanese Circulation Society 2011;75(9):2269-79.
2011: Takehiro Takagi; Osamu Taguchi; Masaaki Toda; Daniel Boveda Ruiz; Paloma Gil Bernabe; Corina N D'Alessandro-Gabazza; Yasushi Miyake; Tetsu Kobayashi; Shinya Aoki; Fumiko Chiba; Yutaka Yano; Edward M Conway; Seiichi Munesue; Yasuhiko Yamamoto; Hiroshi Yamamoto; Koji Suzuki; Yoshiyuki Takei; John Morser; Esteban C Gabazza
Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells.
American journal of respiratory and critical care medicine 2011;183(1):31-42.
2010: T Beppu; P Gil-Bernabe; D Boveda-Ruiz; Corina N D'Alessandro-Gabazza; Y Matsuda; M Toda; Y Miyake; K Shiraki; M Murata; T Murata; Y Yano; John Morser; Esteban C Gabazza; Y Takei
High incidence of tumors in diabetic thrombin activatable fibrinolysis inhibitor and apolipoprotein E double-deficient mice.
Journal of thrombosis and haemostasis : JTH 2010;8(11):2514-22.
2010: Monica M Dua; Noriyuki Miyama; Junya Azuma; Geoffrey M Schultz; Mien Sho; John Morser; Ronald L Dalman
Hyperglycemia modulates plasminogen activator inhibitor-1 expression and aortic diameter in experimental aortic aneurysm disease.
Surgery 2010;148(2):429-35.
2010: Geoffrey Schultz; Maureen M Tedesco; Eiketsu Sho; Toshihiko Nishimura; Shadi Sharif; Xiaoyan Du; Timothy Myles; John Morser; Ronald L Dalman; Lawrence L K Leung
Enhanced abdominal aortic aneurysm formation in thrombin-activatable procarboxypeptidase B-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(7):1363-70.
2010: John Morser; E C Gabazza; Timothy Myles; Lawrence L K Leung
What has been learnt from the thrombin-activatable fibrinolysis inhibitor-deficient mouse?
Journal of thrombosis and haemostasis : JTH 2010;8(5):868-76.
2010: L Qin; Corina N D'Alessandro-Gabazza; S Aoki; P Gil-Bernabe; Y Yano; T Takagi; D Boveda-Ruiz; A Y Ramirez Marmol; V T San Martin Montenegro; M Toda; Y Miyake; Osamu Taguchi; Y Takei; John Morser; Esteban C Gabazza
Pulmonary hypertension is ameliorated in mice deficient in thrombin-activatable fibrinolysis inhibitor.
Journal of thrombosis and haemostasis : JTH 2010;8(4):808-16.
2010: Takaya Maruyama; Esteban C Gabazza; John Morser; Takehiro Takagi; Corina N D'Alessandro-Gabazza; Shizu Hirohata; Sei Nakayama; Alexis Y Ramirez; Atsushi Fujiwara; Masahiro Naito; Kimiaki Nishikubo; Hisamichi Yuda; Masamichi Yoshida; Yoshiyuki Takei; Osamu Taguchi
Community-acquired pneumonia and nursing home-acquired pneumonia in the very elderly patients.
Respiratory medicine 2010;104(4):584-92.
2010: Takaya Maruyama; Osamu Taguchi; Michael S Niederman; John Morser; Hiroyasu Kobayashi; Tetsu Kobayashi; Corina D'Alessandro-Gabazza; Sei Nakayama; Kimiaki Nishikubo; Takashi Noguchi; Yoshiyuki Takei; Esteban C Gabazza
Efficacy of 23-valent pneumococcal vaccine in preventing pneumonia and improving survival in nursing home residents: double blind, randomised and placebo controlled trial.
BMJ (Clinical research ed.) 2010;340():c1004.
2009: Takehiro Takagi; Osamu Taguchi; S Aoki; M Toda; A Yamaguchi; Hajime Fujimoto; D Boveda-Ruiz; P Gil-Bernabe; A Y Ramirez; M Naito; Yutaka Yano; Corina N D'Alessandro-Gabazza; A Fujiwara; Yoshiyuki Takei; John Morser; Esteban C Gabazza
Direct effects of protein S in ameliorating acute lung injury.
Journal of thrombosis and haemostasis : JTH 2009;7(12):2053-63.
2009: Shadi A Sharif; Xiaoyan Du; Timothy Myles; Jason J Song; Elizabeth Price; David M Lee; Stuart Goodman; Mariko Nagashima; John Morser; William H Robinson; Lawrence L K Leung
Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis.
Arthritis and rheumatism 2009;60(10):2902-12.
2009: Chris J Scotton; Malvina A Krupiczojc; Melanie Königshoff; Paul F Mercer; Y C Gary Lee; Naftali Kaminski; John Morser; Joseph M Post; Toby M Maher; Andrew G Nicholson; James D Moffatt; Geoffrey J Laurent; Claudia K Derian; Oliver Eickelberg; Rachel C Chambers
Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.
The Journal of clinical investigation 2009;119(9):2550-63.
2009: Takehiro Takagi; John Morser; Esteban C Gabazza; Liqiang Qin; Atsushi Fujiwara; Masaki Naito; Aiko Yamaguchi; Tetsu Kobayashi; Corina N D'Alessandro-Gabazza; Daniel Boveda Ruiz; Paloma Gil Bernabe; Yasuhiko Iwasaki; Yoshiyuki Takei; Osamu Taguchi
The coagulation and protein C pathways in patients with sleep apnea.
Lung 2009;187(4):209-13.
2009: Hajime Akatsuka; Yutaka Yano; Esteban C Gabazza; John Morser; Ryoma Sasaki; Toshinari Suzuki; R Fujiwara; Akira Katsuki; Yoshiyuki Takei; Yasuhiro Sumida
A case of fulminant type 1 diabetes with coxsackie B4 virus infection diagnosed by elevated serum levels of neutralizing antibody.
Diabetes research and clinical practice 2009;84(3):e50-2.
2009: Ayumi Ikeda; Esteban C Gabazza; John Morser; Ichiro Imoto; Mikihito Kuroda; Corina N D'Alessandro-Gabazza; Kenichiro Hara; Daniel Boveda Ruiz; Paloma Gil Bernabe; Masaki Katsurahara; Masaaki Toda; Yoshinao Kobayashi; Yutaka Yano; Yasuhiro Sumida; Koji Suzuki; Osamu Taguchi; Yoshiyuki Takei
Presence of thrombin-activatable fibrinolysis inhibitor in Helicobacter pylori-associated gastroduodenal disease.
Helicobacter 2009;14(2):147-55.
2009: Takaya Maruyama; Yoshiyuki Takei; Esteban C Gabazza; John Morser; Osamu Taguchi
Different bile concentration of micafungin and itraconazole in a patient with candidal cholecystitis.
The Journal of infection 2009;58(4):315-6.
2009: Chengliang Wu; Paul Y Kim; Reg Manuel; Marian Seto; Marc Whitlow; Mariko Nagashima; John Morser; Ann Gils; Paul Declerck; Michael E Nesheim
The roles of selected arginine and lysine residues of TAFI (Pro-CPU) in its activation to TAFIa by the thrombin-thrombomodulin complex.
The Journal of biological chemistry 2009;284(11):7059-67.
2008: Shino Shimizu; Takeshi Shimizu; John Morser; Tetsu Kobayashi; Aiko Yamaguchi; Liqiang Qin; Masaaki Toda; Corina D'Alessandro-Gabazza; Takaya Maruyama; Takehiro Takagi; Yutaka Yano; Yasuhiro Sumida; Tatsuya Hayashi; Yoshiyuki Takei; Osamu Taguchi; Koji Suzuki; Esteban C Gabazza
Role of the coagulation system in allergic inflammation in the upper airways.
Clinical immunology (Orlando, Fla.) 2008;129(2):365-71.
2008: Nelson E Bruno; Yutaka Yano; Yoshiyuki Takei; Liqiang Qin; Toshinari Suzuki; John Morser; Corina N D'Alessandro-Gabazza; Akira Mizoguchi; Koji Suzuki; Osamu Taguchi; Esteban C Gabazza; Yasuhiro Sumida
Immune complex-mediated glomerulonephritis is ameliorated by thrombin-activatable fibrinolysis inhibitor deficiency.
Thrombosis and haemostasis 2008;100(1):90-100.
2008: Marc Adler; Brad Buckman; Judi Bryant; Zheng Chang; Kieu Chu; Kumar Emayan; Paul Hrvatin; Imadul Islam; John Morser; Drew Sukovich; Christopher West; Shendong Yuan; Marc Whitlow
Structures of potent selective peptide mimetics bound to carboxypeptidase B.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 2):149-57.
2008: Joseph M Post; Serene Alexander; Yi-Xin Wang; Jon Vincelette; Ron Vergona; Lorraine Kent; Judi Bryant; Mark E Sullivan; William P Dole; John Morser; Babu Subramanyam
Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): pharmacodynamic and pharmacokinetic characterization.
Thrombosis research 2008;122(4):533-40.
2008: Judi Bryant; Joseph M Post; Serene Alexander; Yi-Xin Wang; Lorraine Kent; Sabine Schirm; Jih-Lie Tseng; Babu Subramanyam; Brad Buckman; Imadul Islam; Shendong Yuan; Mark E Sullivan; Mike Snider; John Morser
Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (I): in vitro effects on platelets.
Thrombosis research 2008;122(4):523-32.
2008: Nelson E Bruno; Yutaka Yano; Yoshiyuki Takei; Esteban C Gabazza; L Qin; M Nagashima; John Morser; Corina N D'Alessandro-Gabazza; Osamu Taguchi; Yasuhiro Sumida
Protective role of thrombin activatable fibrinolysis inhibitor in obstructive nephropathy-associated tubulointerstitial fibrosis.
Journal of thrombosis and haemostasis : JTH 2008;6(1):139-46.
2007: Yi-Xin Wang; Jon Vincelette; Valdeci da Cunha; Baby Martin-McNulty; Cornell Mallari; Richard M Fitch; Serene Alexander; Imadul Islam; Brad Buckman; Shendong Yuan; Joseph M Post; Babu Subramanyam; Ronald Vergona; Mark E Sullivan; William P Dole; John Morser; Judi Bryant
A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models.
Thrombosis and haemostasis 2007;97(5):847-55.
2007: Imadul Islam; Judi Bryant; Karen May; Raju Mohan; Shendong Yuan; Lorraine Kent; John Morser; Lei Zhao; Ronald Vergona; Kathy White; Marc Adler; Marc Whitlow; Brad Buckman
3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa).
Bioorganic & medicinal chemistry letters 2007;17(5):1349-54.
2007: Yi-Xin Wang; Valdeci da Cunha; Jon Vincelette; Lei Zhao; Mariko Nagashima; Kohichi Kawai; Shendong Yuan; Kumar Emayan; Imadul Islam; Junko Hosoya; Mark E Sullivan; William P Dole; John Morser; Brad Buckman; Ronald Vergona
A novel inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa) - part II: enhancement of both exogenous and endogenous fibrinolysis in animal models of thrombosis.
Thrombosis and haemostasis 2007;97(1):54-61.
2007: Yi-Xin Wang; Lei Zhao; Mariko Nagashima; Jon Vincelette; Drew Sukovich; Weiwei Li; Babu Subramanyam; Shendong Yuan; Kumar Emayan; Imadul Islam; Paul Hrvatin; Judi Bryant; David R Light; Ronald Vergona; John Morser; Brad Buckman
A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) - part I: pharmacological characterization.
Thrombosis and haemostasis 2007;97(1):45-53.
2006: Hajime Fujimoto; Esteban C Gabazza; Osamu Taguchi; Yoichi Nishii; Hiroki Nakahara; Nelson E Bruno; Corina N D'Alessandro-Gabazza; Michael Kasper; Yutaka Yano; Mariko Nagashima; John Morser; George J Broze; Koji Suzuki; Yukihiko Adachi
Thrombin-activatable fibrinolysis inhibitor deficiency attenuates bleomycin-induced lung fibrosis.
The American journal of pathology 2006;168(4):1086-96.
2005: Jon Vincelette; Rene Pagila; Kohichi Kawai; Masaaki Ishii; Yuko Horimizu; Ronald Vergona; Mark E Sullivan; John Morser; William P Dole; Yi-Xin Wang
Inhibition of rho-kinase by hydroxyfasudil prevents vasopressin-induced myocardial ischemia in Donryu rats by attenuating coronary vasoconstriction.
Pharmacology 2005;75(3):145-51.
2005: Jian-Ming Gu; Anthony Johns; John Morser; William P Dole; David Greaves; Gary G Deng
Urokinase plasminogen activator receptor promotes macrophage infiltration into the vascular wall of ApoE deficient mice.
Journal of cellular physiology 2005;204(1):73-82.
2005: John Morser; Fiona M McDonald
The Promises and Challenges of Regenerative Medicine, October 20-22, 2004, Kobe, Japan.
Stem cells (Dayton, Ohio) 2005;23(5):707-9.
2005: Hideyuki Migita; John Morser
15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) signals through retinoic acid receptor-related orphan receptor-alpha but not peroxisome proliferator-activated receptor-gamma in human vascular endothelial cells: the effect of 15d-PGJ2 on tumor necrosis factor-alpha-induced gene expression.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(4):710-6.
2005: Joyce C Y Chan; Ole Knudson; Faye Wu; John Morser; William P Dole; Qingyu Wu
Hypertension in mice lacking the proatrial natriuretic peptide convertase corin.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):785-90.
2005: Amy Liang; Faye Wu; Kathy Tran; Steven W Jones; Gary Deng; Bin Ye; Zhuchun Zhao; R Michael Snider; William P Dole; John Morser; Qingyu Wu
Characterization of a small molecule PAI-1 inhibitor, ZK4044.
Thrombosis research 2005;115(4):341-50.
2004: Ning-zheng Dong; Valdeci da Cunha; Andrej Citkowicz; Faye Wu; Jon Vincelette; Brent Larsen; Yi-Xin Wang; Changgeng Ruan; William P Dole; John Morser; Qingyu Wu; Junliang Pan
P-selectin-targeting of the fibrin selective thrombolytic Desmodus rotundus salivary plasminogen activator alpha1.
Thrombosis and haemostasis 2004;92(5):956-65.
2004: Barry W Festoff; Syed Ameenuddin; Karen SantaCruz; John Morser; Zhiming Suo; Paul M Arnold; Kristie E Stricker; Bruce A. Citron
Neuroprotective effects of recombinant thrombomodulin in controlled contusion spinal cord injury implicates thrombin signaling.
Journal of neurotrauma 2004;21(7):907-22.
2004: Hideyuki Migita; John Morser; Kohichi Kawai
Rev-erbalpha upregulates NF-kappaB-responsive genes in vascular smooth muscle cells.
FEBS letters 2004;561(1-3):69-74.
2004: Hideyuki Migita; Noboru Satozawa; Jiing-Huey Lin; John Morser; Kohichi Kawai
RORalpha1 and RORalpha4 suppress TNF-alpha-induced VCAM-1 and ICAM-1 expression in human endothelial cells.
FEBS letters 2004;557(1-3):269-74.
2003: Sabine Knappe; Faye Wu; Mary Rose Masikat; John Morser; Qingyu Wu
Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin.
The Journal of biological chemistry 2003;278(52):52363-70.
2003: Timothy Myles; Toshihiko Nishimura; Thomas H Yun; Mariko Nagashima; John Morser; Andrew J Patterson; Ronald G Pearl; Lawrence L K Leung
Thrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammation.
The Journal of biological chemistry 2003;278(51):51059-67.
2003: Triantafyllos Chavakis; Angelika Bierhaus; Nadia Al-Fakhri; Darius Schneider; Steffen Witte; Thomas Linn; Mariko Nagashima; John Morser; Bernd Arnold; Klaus T Preissner; Peter P Nawroth
The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment.
The Journal of experimental medicine 2003;198(10):1507-15.
2003: Chengliang Wu; Ning-zheng Dong; Valdeci da Cunha; Baby Martin-McNulty; Katherine Tran; Mariko Nagashima; Qingyu Wu; John Morser; Yi-Xin Wang
Activated thrombin-activatable fibrinolysis inhibitor attenuates spontaneous fibrinolysis of batroxobin-induced fibrin deposition in rat lungs.
Thrombosis and haemostasis 2003;90(3):414-21.
2003: Dana R Abendschein; PK Baum; David R Light; John Morser
Effect of vascular injury on inhibition of venous thrombosis with ZK-807834, a direct inhibitor of factor Xa.
Journal of thrombosis and haemostasis : JTH 2003;1(9):1955-8.
2003: Lei Zhao; Brad Buckman; Marian Seto; John Morser; Mariko Nagashima
Mutations in the substrate binding site of thrombin-activatable fibrinolysis inhibitor (TAFI) alter its substrate specificity.
The Journal of biological chemistry 2003;278(34):32359-66.
2003: Chengliang Wu; Faye Wu; Junliang Pan; John Morser; Qingyu Wu
Furin-mediated processing of Pro-C-type natriuretic peptide.
The Journal of biological chemistry 2003;278(28):25847-52.
2003: Amy M Liang; David R Light; Monica J Kochanny; Galina Rumennik; Lan Trinh; Dao Lentz; Joseph Post; John Morser; Michael Snider
Discovery and characterization of a potent and selective non-amidine inhibitor of human factor Xa.
Biochemical pharmacology 2003;65(9):1407-18.
2003: Yi Xin Wang; Ning-zheng Dong; Chengliang Wu; Baby Martin-McNulty; Richard M Fitch; Valdeci da Cunha; Jon Vicelette; Katherine Tran; Ronald Vergona; Mark E Sullivan; John Morser; Qingyu Wu
Lipopolysaccharide attenuates thrombolysis in batroxobin-induced lung vasculature fibrin deposition but not in ferrous chloride-induced carotid artery thrombus in rats: role of endogenous PAI-1.
Thrombosis research 2003;111(6):381-7.
2002: Junliang Pan; Bernd Hinzmann; Wei Yan; Faye Wu; John Morser; Qingyu Wu
Genomic structures of the human and murine corin genes and functional GATA elements in their promoters.
The Journal of biological chemistry 2002;277(41):38390-8.
2002: Faye Wu; Wei Yan; Junliang Pan; John Morser; Qingyu Wu
Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes.
The Journal of biological chemistry 2002;277(19):16900-5.
2002: Mark Schneider; Mariko Nagashima; Sabine Knappe; Lei Zhao; John Morser; Michael E Nesheim
Amino acid residues in the P6-P'3 region of thrombin-activable fibrinolysis inhibitor (TAFI) do not determine the thrombomodulin dependence of TAFI activation.
The Journal of biological chemistry 2002;277(12):9944-51.
2002: Mariko Nagashima; Zheng-Feng Yin; George J Broze; John Morser
Thrombin-activatable fibrinolysis inhibitor (TAFI) deficient mice.
Frontiers in bioscience : a journal and virtual library 2002;7():d556-68.
2002: Mariko Nagashima; Zheng-Feng Yin; Lei Zhao; Kathy White; Yanhong Zhu; Nina Lasky; Meredith Halks-Miller; George J Broze; William P Fay; John Morser
Thrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life.
The Journal of clinical investigation 2002;109(1):101-10.
2001: Yi Xin Wang; Baby Martin-McNulty; Ana Freay; Drew A Sukovich; Meredith Halks-Miller; W W Li; Ronald Vergona; Mark E Sullivan; John Morser; William P Dole; Gary G Deng
Angiotensin II increases urokinase-type plasminogen activator expression and induces aneurysm in the abdominal aorta of apolipoprotein E-deficient mice.
The American journal of pathology 2001;159(4):1455-64.
2001: Kirk McLean; Sabine Schirm; Anthony Johns; John Morser; David R Light
FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834.
Thrombosis research 2001;103(4):281-97.
2000: W Wang; Mariko Nagashima; Mark Schneider; John Morser; Michael E Nesheim
Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation.
The Journal of biological chemistry 2000;275(30):22942-7.
2000: W Yan; F Wu; John Morser; Q Wu
Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8525-9.
2000: Mariko Nagashima; M Werner; M Wang; Lei Zhao; David R Light; Rene Pagila; John Morser; Peter F Verhallen
An inhibitor of activated thrombin-activatable fibrinolysis inhibitor potentiates tissue-type plasminogen activator-induced thrombolysis in a rabbit jugular vein thrombolysis model.
Thrombosis research 2000;98(4):333-42.
2000: Pablo Fuentes-Prior; Y Iwanaga; Robert Huber; Rene Pagila; Galina Rumennik; M Seto; John Morser; David R Light; Wolfram Bode
Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex.
Nature 2000;404(6777):518-25.
1999: Scott W Hall; M Nagashima; L Zhao; John Morser; Lawrence L K Leung
Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains.
The Journal of biological chemistry 1999;274(36):25510-6.
1999: David R Light; Charles B Glaser; M Betts; Eric Blasko; E Campbell; J H Clarke; M McCaman; Kirk McLean; M Nagashima; John Parkinson; Galina Rumennik; T Young; John Morser
The interaction of thrombomodulin with Ca2+.
European journal of biochemistry / FEBS 1999;262(2):522-33.
1998: Lei Zhao; John Morser; Laszlo Bajzar; Michael E Nesheim; Mariko Nagashima
Identification and characterization of two thrombin-activatable fibrinolysis inhibitor isoforms.
Thrombosis and haemostasis 1998;80(6):949-55.
1998: Laszlo Bajzar; Michael E Nesheim; John Morser; Paula B Tracy
Both cellular and soluble forms of thrombomodulin inhibit fibrinolysis by potentiating the activation of thrombin-activable fibrinolysis inhibitor.
The Journal of biological chemistry 1998;273(5):2792-8.
1998: Q Wu; D Yu; Joe Post; Meredith Halks-Miller; J E Sadler; John Morser
Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease.
The Journal of clinical investigation 1998;101(2):321-6.
1997: Michael E Nesheim; W Wang; Michael B Boffa; Mariko Nagashima; John Morser; Laszlo Bajzar
Thrombin, thrombomodulin and TAFI in the molecular link between coagulation and fibrinolysis.
Thrombosis and haemostasis 1997;78(1):386-91.
1997: Hélène C F Côté; Laszlo Bajzar; WK Stevens; John Samis; John Morser; Ross T A MacGillivray; Michael E Nesheim
Functional characterization of recombinant human meizothrombin and Meizothrombin(desF1). Thrombomodulin-dependent activation of protein C and thrombin-activatable fibrinolysis inhibitor (TAFI), platelet aggregation, antithrombin-III inhibition.
The Journal of biological chemistry 1997;272(10):6194-200.
1996: Laszlo Bajzar; John Morser; Michael E Nesheim
TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex.
The Journal of biological chemistry 1996;271(28):16603-8.
1995: M Adler; M H Seto; D E Nitecki; J H Lin; D R Light; John Morser
The structure of a 19-residue fragment from the C-loop of the fourth epidermal growth factor-like domain of thrombomodulin.
The Journal of biological chemistry 1995;270(40):23366-72.
1994: J H Lin; K McLean; John Morser; T A Young; R M Wydro; W H Andrews; D R Light
Modulation of glycosaminoglycan addition in naturally expressed and recombinant human thrombomodulin.
The Journal of biological chemistry 1994;269(40):25021-30.
1994: J H Lin; M Wang; W H Andrews; R Wydro; John Morser
Expression efficiency of the human thrombomodulin-encoding gene in various vector and host systems.
Gene 1994;147(2):287-92.
1994: M Fredrich; R Zierz; John Morser; R Wydro; W Witt
A new animal model of venous thrombosis in rats with low flow conditions in the venous blood stream.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1994;5(2):243-8.
1994: M M Solis; M Vitti; J Cook; D Young; Charles B Glaser; D Light; John Morser; R Wydro; S Yu; Louis M Fink
Recombinant soluble human thrombomodulin: a randomized, blinded assessment of prevention of venous thrombosis and effects on hemostatic parameters in a rat model.
Thrombosis research 1994;73(6):385-94.
1993: J H Clarke; D R Light; Eric Blasko; John Parkinson; M Nagashima; K McLean; L Vilander; W H Andrews; John Morser; Charles B Glaser
The short loop between epidermal growth factor-like domains 4 and 5 is critical for human thrombomodulin function.
The Journal of biological chemistry 1993;268(9):6309-15.
1993: Louis M Fink; John F Eidt; K Johnson; J M Cook; C D Cook; John Morser; Richard A Marlar; C L Collins; R Schaefer; S S Xie
Thrombomodulin activity and localization.
The International journal of developmental biology 1993;37(1):221-6.
1993: M Nagashima; E Lundh; J C Leonard; John Morser; John Parkinson
Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity.
The Journal of biological chemistry 1993;268(4):2888-92.
1992: Charles B Glaser; John Morser; J H Clarke; Eric Blasko; K McLean; I Kuhn; R J Chang; J H Lin; L Vilander; W H Andrews
Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation.
The Journal of clinical investigation 1992;90(6):2565-73.
1992: John Parkinson; M Nagashima; I Kuhn; J Leonard; John Morser
Structure-function studies of the epidermal growth factor domains of human thrombomodulin.
Biochemical and biophysical research communications 1992;185(2):567-76.
1991: M M Solis; C Cook; J Cook; Charles B Glaser; D Light; John Morser; S C Yu; Louis M Fink; John F Eidt
Intravenous recombinant soluble human thrombomodulin prevents venous thrombosis in a rat model.
Journal of vascular surgery 1991;14(5):599-604.
1990: S W Gao; John Morser; K McLean; Marc Shuman
Differential effect of platelets on plasminogen activation by tissue plasminogen activator, urokinase, and streptokinase.
Thrombosis research 1990;58(4):421-33.