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Nicholas Morton

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Sophie Turban; Brian R Walker; Scott P Webster; Donald R Dunbar; Xiaoxia Liu; John J Mullins; Lynne Ramage; Jonathan R Seckl; Nicholas M Morton
Optimal elevation of β-cell 11β-hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high-fat diet-induced β-cell failure.
Zoi Michailidou; Eileen Miller; Nicholas M Morton; Peter J Ratcliffe; Joerg Schrader; Patrick W F Hadoke; John P Iredale; Sophie Turban; Brian R Walker; Xiantong Zou; Jonathan R Seckl
Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice.
Cristina L Esteves; Val Kelly; Achim Leutz; Tak Y Man; Nicholas M Morton; Jonathan R Seckl; Valérie Bégay; Karen E Chapman
Regulation of adipocyte 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) by CCAAT/enhancer-binding protein (C/EBP) β isoforms, LIP and LAP.

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All Publications

2012: Sophie Turban; Brian R Walker; Scott P Webster; Donald R Dunbar; Xiaoxia Liu; John J Mullins; Lynne Ramage; Jonathan R Seckl; Nicholas M Morton
Optimal elevation of β-cell 11β-hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high-fat diet-induced β-cell failure.
Diabetes 2012;61(3):642-52.
2012: Zoi Michailidou; Eileen Miller; Nicholas M Morton; Peter J Ratcliffe; Joerg Schrader; Patrick W F Hadoke; John P Iredale; Sophie Turban; Brian R Walker; Xiantong Zou; Jonathan R Seckl
Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice.
The Journal of biological chemistry 2012;287(6):4188-97.
2012: Cristina L Esteves; Val Kelly; Achim Leutz; Tak Y Man; Nicholas M Morton; Jonathan R Seckl; Valérie Bégay; Karen E Chapman
Regulation of adipocyte 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) by CCAAT/enhancer-binding protein (C/EBP) β isoforms, LIP and LAP.
PloS one 2012;7(5):e37953.
2011: Pauline M Jamieson; P A T Kelly; Y Kuperman; Nicholas M Morton; K J Mustard; Jonathan R Seckl; David G Brownstein; R N Carter; Alon Chen; M E Cleasby; C N Hahn; D Grahame Hardie; J M Vaughan; Wylie W Vale
Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet.
Diabetologia 2011;54(9):2392-403.
2011: Tak Yung Man; Zoi Michailidou; Adnan Gokcel; Lynne Ramage; Karen E Chapman; Christopher J Kenyon; Jonathan R Seckl; Nicholas M Morton
Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11β-hydroxysteroid dehydrogenase type 1.
American journal of physiology. Endocrinology and metabolism 2011;300(6):E1076-84.
2011: Malgorzata Wamil; Jenny H Battle; Sophie Turban; Tiina Kipari; David Seguret; Ricardo de Sousa Peixoto; Yvonne B Nelson; Dominika Nowakowska; David Ferenbach; Lynne Ramage; Karen E Chapman; Jeremy Hughes; Donald R Dunbar; Jonathan R Seckl; Nicholas M Morton
Novel fat depot-specific mechanisms underlie resistance to visceral obesity and inflammation in 11 β-hydroxysteroid dehydrogenase type 1-deficient mice.
Diabetes 2011;60(4):1158-67.
2011: David P Macfarlane; Xiantong Zou; Ruth Andrew; Nicholas M Morton; Dawn E W Livingstone; Rebecca L Aucott; Moffat J Nyirenda; John P Iredale; Brian R Walker
Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis.
American journal of physiology. Endocrinology and metabolism 2011;300(2):E402-9.
2011: Nicholas M Morton; Yvonne B Nelson; Lynne Ramage; Jonathan R Seckl; Patrick W F Hadoke; Simon Horvat; Christopher J Kenyon; Zoi Michailidou; Lutz Bunger; Emma M Di Rollo; Donald R Dunbar
A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies novel candidate obesity genes.
PloS one 2011;6(9):e23944.
2010: Nicholas M Morton
Obesity and corticosteroids: 11beta-hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease.
Molecular and cellular endocrinology 2010;316(2):154-64.
2010: Roland H Stimson; Gerald E Lobley; Ioanna Maraki; Nicholas M Morton; Ruth Andrew; Brian R Walker
Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats.
PloS one 2010;5(1):e8779.
2008: malgorzata WAMIL; Ruth Andrew; Karen E Chapman; Jonathan Street; Nicholas M Morton; Jonathan R Seckl
7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type.
Endocrinology 2008;149(12):5909-18.
2008: Zoi Michailidou; R N Carter; E Marshall; H G Sutherland; D G Brownstein; E Owen; K Cockett; V Kelly; L Ramage; E A S Al-Dujaili; M Ross; I Maraki; K Newton; Megan C Holmes; Jonathan R Seckl; Nicholas M Morton; Christopher J Kenyon; Karen E Chapman
Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(11):3896-907.
2008: R A De Sousa Peixoto; S Turban; J H Battle; Karen E Chapman; Jonathan R Seckl; Nicholas M Morton
Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo.
Endocrinology 2008;149(4):1861-8.
2008: Nicholas M Morton; Jonathan R Seckl
11beta-hydroxysteroid dehydrogenase type 1 and obesity.
Frontiers of hormone research 2008;36():146-64.
2007: Roland H Stimson; Alexandra M Johnstone; Natalie Z M Homer; Deborah J Wake; Nicholas M Morton; Ruth Andrew; Gerald E Lobley; Brian R Walker
Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men.
The Journal of clinical endocrinology and metabolism 2007;92(11):4480-4.
2007: Zoi Michailidou; Anthony P Coll; Christopher J Kenyon; Nicholas M Morton; Stephen O'Rahilly; Jonathan R Seckl; Karen E Chapman
Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone.
The Journal of endocrinology 2007;194(1):161-70.
2007: Zoi Michailidou; Michael D Jensen; Daniel A Dumesic; Karen E Chapman; Jonathan R Seckl; Brian R Walker; Nicholas M Morton
Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity.
Obesity (Silver Spring, Md.) 2007;15(5):1155-63.
2006: Valerie S Densmore; Nicholas M Morton; John J Mullins; Jonathan R Seckl
11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: A novel constraint to hyperphagia?
Endocrinology 2006;147(9):4486-95.
2006: Julia H Goedecke; Deborah J Wake; Naomi S Levitt; Estelle V Lambert; M R Collins; Nicholas M Morton; Ruth Andrew; Jonathan R Seckl; Brian R Walker
Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women.
Clinical endocrinology 2006;65(1):81-7.
2006: Charlotte Bruley; Val Lyons; Alan G F Worsley; Margaret D Wilde; Gretchen D Darlington; Nicholas M Morton; Jonathan R Seckl; Karen E Chapman
A novel promoter for the 11beta-hydroxysteroid dehydrogenase type 1 gene is active in lung and is C/EBPalpha independent.
Endocrinology 2006;147(6):2879-85.
2005: Nicholas M Morton; Valerie Densmore; malgorzata WAMIL; Lynne Ramage; Katherine Nichol; Lutz Bünger; Jonathan R Seckl; Christopher J Kenyon
A polygenic model of the metabolic syndrome with reduced circulating and intra-adipose glucocorticoid action.
Diabetes 2005;54(12):3371-8.
2005: Erin E Kershaw; Nicholas M Morton; Harveen Dhillon; Lynne Ramage; Jonathan R Seckl; Jeffrey S Flier
Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity.
Diabetes 2005;54(4):1023-31.
2005: Amanda J Drake; Dawn E W Livingstone; Ruth Andrew; Jonathan R Seckl; Nicholas M Morton; Brian R Walker
Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats.
Endocrinology 2005;146(2):913-9.
2004: Nicholas M Morton; Lynne Ramage; Jonathan R Seckl
Down-regulation of adipose 11beta-hydroxysteroid dehydrogenase type 1 by high-fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease.
Endocrinology 2004;145(6):2707-12.
2004: Janice M Paterson; Nicholas M Morton; Catherine Fievet; Christopher J Kenyon; Megan C Holmes; Bart Staels; Jonathan R Seckl; John J Mullins
Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7088-93.
2004: Nicholas M Morton; Janice M Paterson; Hiroaki Masuzaki; Megan C Holmes; Bart Staels; Catherine Fievet; Brian R Walker; Jeffrey S Flier; John J Mullins; Jonathan R Seckl
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.
Diabetes 2004;53(4):931-8.
2004: Jonathan R Seckl; Nicholas M Morton; Karen E Chapman; Brian R Walker
Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue.
Recent progress in hormone research 2004;59():359-93.
2003: Hiroaki Masuzaki; Hiroshi Yamamoto; Christopher J Kenyon; Joel K Elmquist; Nicholas M Morton; Janice M Paterson; Hiroshi Shinyama; Matthew G F Sharp; Stewart Fleming; John J Mullins; Jonathan R Seckl; Jeffrey S Flier
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.
The Journal of clinical investigation 2003;112(1):83-90.
2001: Hiroaki Masuzaki; J Paterson; Hiroshi Shinyama; Nicholas M Morton; John J Mullins; Jonathan R Seckl; Jeffrey S Flier
A transgenic model of visceral obesity and the metabolic syndrome.
Science (New York, N.Y.) 2001;294(5549):2166-70.
2001: Nicholas M Morton; Megan C Holmes; Catherine Fiévet; Bart Staels; Anne Tailleux; John J Mullins; Jonathan R Seckl
Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice.
The Journal of biological chemistry 2001;276(44):41293-300.