Brooke Mossman

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Shukla Arti; Bosenberg Marcus W; MacPherson Maximilian B; Butnor Kelly J; Heintz Nicholas H; Pass Harvey I; Carbone Michele; Testa Joseph R; Mossman Brooke T
Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis.
Shukla Arti; MacPherson Maximilian B; Hillegass Jedd; Ramos-Nino Maria E; Alexeeva Vlada; Vacek Pamela M; Bond Jeffrey P; Pass Harvey I; Steele Chad; Mossman Brooke T
Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity.
Haegens Astrid; Heeringa Peter; van Suylen Robert Jan; Steele Chad; Aratani Yasuaki; O'Donoghue Robert J J; Mutsaers Steven E; Mossman Brooke T; Wouters Emiel F M; Vernooy Juanita H J
Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production.

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All Publications

2009: Shukla Arti; Bosenberg Marcus W; MacPherson Maximilian B; Butnor Kelly J; Heintz Nicholas H; Pass Harvey I; Carbone Michele; Testa Joseph R; Mossman Brooke T
Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis.
The American journal of pathology 2009;175(5):2197-206.
2009: Shukla Arti; MacPherson Maximilian B; Hillegass Jedd; Ramos-Nino Maria E; Alexeeva Vlada; Vacek Pamela M; Bond Jeffrey P; Pass Harvey I; Steele Chad; Mossman Brooke T
Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity.
American journal of respiratory cell and molecular biology 2009;41(1):114-23.
2009: Haegens Astrid; Heeringa Peter; van Suylen Robert Jan; Steele Chad; Aratani Yasuaki; O'Donoghue Robert J J; Mutsaers Steven E; Mossman Brooke T; Wouters Emiel F M; Vernooy Juanita H J
Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7990-6.
2009: Buder-Hoffmann Sylke A; Shukla Arti; Barrett Trisha F; MacPherson Maximilian B; Lounsbury Karen M; Mossman Brooke T
A protein kinase Cdelta-dependent protein kinase D pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos.
The American journal of pathology 2009;174(2):449-59.
2008: Stevens J P; Zahardis J; MacPherson M; Mossman B T; Petrucci G A
A new method for quantifiable and controlled dosage of particulate matter for in vitro studies: the electrostatic particulate dosage and exposure system (EPDExS).
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(7):1768-74.
2008: Mossman Brooke T
Assessment of the pathogenic potential of asbestiform vs. nonasbestiform particulates (cleavage fragments) in in vitro (cell or organ culture) models and bioassays.
Regulatory toxicology and pharmacology : RTP 2008;52(1 Suppl):S200-3.
2008: Fukagawa Naomi K; Li Muyao; Sabo-Attwood Tara; Timblin Cynthia R; Butnor Kelly J; Gagne Jessica; Steele Chad; Taatjes Douglas J; Huber Sally; Mossman Brooke T
Inhaled asbestos exacerbates atherosclerosis in apolipoprotein E-deficient mice via CD4+ T cells.
Environmental health perspectives 2008;116(9):1218-25.
2008: Janssen-Heininger Yvonne M W; Mossman Brooke T; Heintz Nicholas H; Forman Henry J; Kalyanaraman Balaraman; Finkel Toren; Stamler Jonathan S; Rhee Sue Goo; van der Vliet Albert
Redox-based regulation of signal transduction: principles, pitfalls, and promises.
Free radical biology & medicine 2008;45(1):1-17.
2008: Dostert Catherine; Pétrilli Virginie; Van Bruggen Robin; Steele Chad; Mossman Brooke T; Tschopp Jürg
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
Science (New York, N.Y.) 2008;320(5876):674-7.
2008: Barlow Christy A; Kitiphongspattana Kajorn; Siddiqui Nazli; Roe Michael W; Mossman Brooke T; Lounsbury Karen M
Protein kinase A-mediated CREB phosphorylation is an oxidant-induced survival pathway in alveolar type II cells.
Apoptosis : an international journal on programmed cell death 2008;13(5):681-92.
2008: Manning Christopher B; Sabo-Attwood Tara; Robledo Raymond F; Macpherson Maximilian B; Rincón Mercedes; Vacek Pamela; Hemenway David; Taatjes Douglas J; Lee Patty J; Mossman Brooke T
Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestos.
American journal of respiratory cell and molecular biology 2008;38(5):618-26.
2008: Ramos-Nino Maria E; Blumen Steven R; Sabo-Attwood Tara; Pass Harvey; Carbone Michele; Testa Joseph R; Altomare Deborah A; Mossman Brooke T
HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway.
American journal of respiratory cell and molecular biology 2008;38(2):209-17.
2008: Levis Jamie; Loi Roberto; Butnor Kelly J; Vacek Pamela; Steele Chad; Mossman Brooke T; Weiss Daniel J
Decreased asbestos-induced lung inflammation and fibrosis after radiation and bone marrow transplant.
American journal of respiratory cell and molecular biology 2008;38(1):16-25.
2007: Mossman Brooke T; Shukla Arti; Fukagawa Naomi K
Highlight Commentary on "Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles".
Free radical biology & medicine 2007;43(4):504-5.
2007: Barlow Christy A; Barrett Trisha F; Shukla Arti; Mossman Brooke T; Lounsbury Karen M
Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2.
American journal of physiology. Lung cellular and molecular physiology 2007;292(6):L1361-9.
2007: Blumen Steven R; Cheng Kai; Ramos-Nino Maria E; Taatjes Douglas J; Weiss Daniel J; Landry Christopher C; Mossman Brooke T
Unique uptake of acid-prepared mesoporous spheres by lung epithelial and mesothelioma cells.
American journal of respiratory cell and molecular biology 2007;36(3):333-42.
2007: Haegens Astrid; Barrett Trisha F; Gell Joanna; Shukla Arti; Macpherson Maximilian; Vacek Pamela; Poynter Matthew E; Butnor Kelly J; Janssen-Heininger Yvonne M; Steele Chad; Mossman Brooke T
Airway epithelial NF-kappaB activation modulates asbestos-induced inflammation and mucin production in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1800-8.
2007: Shukla Arti; Lounsbury Karen M; Barrett Trisha F; Gell Joanna; Rincon Mercedes; Butnor Kelly J; Taatjes Douglas J; Davis Gerald S; Vacek Pamela; Nakayama Keiichi I; Nakayama Keiko; Steele Chad; Mossman Brooke T
Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice.
The American journal of pathology 2007;170(1):140-51.
2007: Ramos-Nino Maria E; Blumen Steven R; Pass Harvey; Mossman Brooke T
Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas.
Molecular cancer 2007;6():81.
2007: Mossman Brooke T; Borm Paul J; Castranova Vincent; Costa Daniel L; Donaldson Kenneth; Kleeberger Steven R
Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases.
Particle and fibre toxicology 2007;4():4.
2006: Li Muyao; Chiu Jen-Fu; Mossman Brooke T; Fukagawa Naomi K
Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats.
The Journal of biological chemistry 2006;281(52):40429-39.
2006: O'Hara Kimberley A; Nemec Antonia A; Alam Jawed; Klei Linda R; Mossman Brooke T; Barchowsky Aaron
Chromium (VI) inhibits heme oxygenase-1 expression in vivo and in arsenic-exposed human airway epithelial cells.
Journal of cellular physiology 2006;209(1):113-21.
2006: Kroczynska Barbara; Cutrone Rochelle; Bocchetta Maurizio; Yang Haining; Elmishad Amira G; Vacek Pamela; Ramos-Nino Maria; Mossman Brooke T; Pass Harvey I; Carbone Michele
Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):14128-33.
2006: Yang Haining; Bocchetta Maurizio; Kroczynska Barbara; Elmishad Amira G; Chen Yuanbin; Liu Zemin; Bubici Concetta; Mossman Brooke T; Pass Harvey I; Testa Joseph R; Franzoso Guido; Carbone Michele
TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(27):10397-402.
2006: Ramos-Nino Maria E; Testa Joseph R; Altomare Deborah A; Pass Harvey I; Carbone Michele; Bocchetta Maurizio; Mossman Brooke T
Cellular and molecular parameters of mesothelioma.
Journal of cellular biochemistry 2006;98(4):723-34.
2006: Mossman Brooke T; Lounsbury Karen M; Reddy Sekhar P
Oxidants and signaling by mitogen-activated protein kinases in lung epithelium.
American journal of respiratory cell and molecular biology 2006;34(6):666-9.
2006: Adler Kenneth B; Shapiro Steven D; Gallup Marianne; Wu Reen; Randell Scott H; Holtzman Michael J; Evans Christopher M; Jacoby David B; Tesfaigzi Yohannes; Rose Mary C; Mossman Brooke T; Prince Alice; Reddy Sekhar P; Davis C William; Matthay Michael A
Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum.
American journal of respiratory cell and molecular biology 2006;34(5):523-6.
2006: Shukla Arti; Barrett Trisha F; Nakayama Keiichi I; Nakayama Kieko; Mossman Brooke T; Lounsbury Karen M
Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(7):997-9.
2006: Li Muyao; Liu Rui-Ming; Timblin Cynthia R; Meyer Suzanne G; Mossman Brooke T; Fukagawa Naomi K
Age affects ERK1/2 and NRF2 signaling in the regulation of GCLC expression.
Journal of cellular physiology 2006;206(2):518-25.
2006: Lee Patty J; Zhang Xuchen; Shan Peiying; Ma Bing; Lee Chun Geun; Homer Robert J; Zhu Zhou; Rincon Mercedes; Mossman Brooke T; Elias Jack A
ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo.
The Journal of clinical investigation 2006;116(1):163-73.
2006: Barlow Christy A; Shukla Arti; Mossman Brooke T; Lounsbury Karen M
Oxidant-mediated cAMP response element binding protein activation: calcium regulation and role in apoptosis of lung epithelial cells.
American journal of respiratory cell and molecular biology 2006;34(1):7-14.
2006: Manning Christopher B; Mossman Brooke T; Taatjes Douglas J
Analysis of asbestos-induced gene expression changes in bronchiolar epithelial cells using laser capture microdissection and quantitative reverse transcriptase-polymerase chain reaction.
Methods in molecular biology (Clifton, N.J.) 2006;319():231-6.
2006: Stern Maria; Taatjes Douglas J; Mossman Brooke T
Multifluorescence labeling techniques and confocal laser scanning microscopy on lung tissue.
Methods in molecular biology (Clifton, N.J.) 2006;319():67-76.
2005: Carbone Michele; Rdzanek Monica A; Rudzinski Jennifer J; De Marco Melissa A; Bocchetta Maurizio; Ramos Niño Maria; Mossman Brooke; Pass Harvey I
SV40 detection in human tumor specimens.
Cancer research 2005;65(21):10120-1.
2005: Haegens Astrid; van der Vliet Albert; Butnor Kelly J; Heintz Nicholas; Taatjes Douglas; Hemenway David; Vacek Pamela; Freeman Bruce A; Hazen Stanley L; Brennan Marie Luise; Mossman Brooke T
Asbestos-induced lung inflammation and epithelial cell proliferation are altered in myeloperoxidase-null mice.
Cancer research 2005;65(21):9670-7.
2005: Sabo-Attwood Tara; Ramos-Nino Maria; Bond Jeffrey; Butnor Kelly J; Heintz Nicholas; Gruber Achim D; Steele Chad; Taatjes Douglas J; Vacek Pamela; Mossman Brooke T
Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesis.
The American journal of pathology 2005;167(5):1243-56.
2005: Altomare Deborah A; You Huihong; Xiao Guang-Hui; Ramos-Nino Maria E; Skele Kristine L; De Rienzo Assunta; Jhanwar Suresh C; Mossman Brooke T; Kane Agnes B; Testa Joseph R
Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth.
Oncogene 2005;24(40):6080-9.
2005: Ramos-Nino Maria E; Vianale Giovina; Sabo-Attwood Tara; Mutti Luciano; Porta Camilo; Heintz Nicholas; Mossman Brooke T
Human mesothelioma cells exhibit tumor cell-specific differences in phosphatidylinositol 3-kinase/AKT activity that predict the efficacy of Onconase.
Molecular cancer therapeutics 2005;4(5):835-42.
2004: Mossman Brooke T; Klein George; Zur Hausen Harald
Modern criteria to determine the etiology of human carcinogens.
Seminars in cancer biology 2004;14(6):449-52.
2004: Shukla Arti; Flanders Trisha; Lounsbury Karen M; Mossman Brooke T
The gamma-glutamylcysteine synthetase and glutathione regulate asbestos-induced expression of activator protein-1 family members and activity.
Cancer research 2004;64(21):7780-6.
2004: Yuan Ziqiang; Taatjes Douglas J; Mossman Brooke T; Heintz Nicholas H
The duration of nuclear extracellular signal-regulated kinase 1 and 2 signaling during cell cycle reentry distinguishes proliferation from apoptosis in response to asbestos.
Cancer research 2004;64(18):6530-6.
2004: Shukla Arti; Vacek Pamela; Mossman Brooke T
Dose-Response Relationships in Expression of Biomarkers of Cell Proliferation in in vitro Assays and Inhalation Experiments.
Nonlinearity in biology, toxicology, medicine 2004;2(2):117-28.
2004: Jung Michael; Grunberg Steven; Timblin Cynthia; Buder-Hoffman Sylke; Vacek Pamela; Taatjes Douglas J; Mossman Brooke T
Paclitaxel and vinorelbine cause synergistic increases in apoptosis but not in microtubular disruption in human lung adenocarcinoma cells (A-549).
Histochemistry and cell biology 2004;121(2):115-21.
2004: Scapoli Luca; Ramos-Nino Maria E; Martinelli Marcella; Mossman Brooke T
Src-dependent ERK5 and Src/EGFR-dependent ERK1/2 activation is required for cell proliferation by asbestos.
Oncogene 2004;23(3):805-13.
2003: Li Muyao; Mossman Brooke T; Kolpa Emily; Timblin Cynthia R; Shukla Arti; Taatjes Douglas J; Fukagawa Naomi K
Age-related differences in MAP kinase activity in VSMC in response to glucose or TNF-alpha.
Journal of cellular physiology 2003;197(3):418-25.
2003: Shukla Arti; Jung Michael; Stern Maria; Fukagawa Naomi K; Taatjes Douglas J; Sawyer Dennis; Van Houten Bennett; Mossman Brooke T
Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis.
American journal of physiology. Lung cellular and molecular physiology 2003;285(5):L1018-25.
2003: Ramos-Nino Maria E; Heintz Nicolas; Scappoli Luca; Martinelli Marcella; Land Susan; Nowak Norma; Haegens Astrid; Manning Brian; Manning Nicole; MacPherson Maximmilian; Stern Maria; Mossman Brooke
Gene profiling and kinase screening in asbestos-exposed epithelial cells and lungs.
American journal of respiratory cell and molecular biology 2003;29(3 Suppl):S51-8.
2003: Shukla Arti; Ramos-Nino Maria; Mossman Brooke
Cell signaling and transcription factor activation by asbestos in lung injury and disease.
The international journal of biochemistry & cell biology 2003;35(8):1198-209.
2003: Shukla Arti; Stern Maria; Lounsbury Karen M; Flanders Trisha; Mossman Brooke T
Asbestos-induced apoptosis is protein kinase C delta-dependent.
American journal of respiratory cell and molecular biology 2003;29(2):198-205.
2003: Ramos-Nino Maria E; Scapoli Luca; Martinelli Marcella; Land Susan; Mossman Brooke T
Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma.
Cancer research 2003;63(13):3539-45.
2003: Shukla Arti; Gulumian Mary; Hei Tom K; Kamp David; Rahman Qamar; Mossman Brooke T
Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases.
Free radical biology & medicine 2003;34(9):1117-29.
2003: Mossman Brooke T
Introduction to serial reviews on the role of reactive oxygen and nitrogen species (ROS/RNS) in lung injury and diseases.
Free radical biology & medicine 2003;34(9):1115-6.
2003: Cummins Andrew B; Palmer Cathy; Mossman Brooke T; Taatjes Douglas J
Persistent localization of activated extracellular signal-regulated kinases (ERK1/2) is epithelial cell-specific in an inhalation model of asbestosis.
The American journal of pathology 2003;162(3):713-20.
2002: Reddy Sekhar P M; Mossman Brooke T
Role and regulation of activator protein-1 in toxicant-induced responses of the lung.
American journal of physiology. Lung cellular and molecular physiology 2002;283(6):L1161-78.
2002: Ramos-Nino Maria E; Timblin Cynthia R; Mossman Brooke T
Mesothelial cell transformation requires increased AP-1 binding activity and ERK-dependent Fra-1 expression.
Cancer research 2002;62(21):6065-9.
2002: Albrecht Catrin; Borm Paul J A; Adolf Brigitte; Timblin Cynthia R; Mossman Brooke T
In vitro and in vivo activation of extracellular signal-regulated kinases by coal dusts and quartz silica.
Toxicology and applied pharmacology 2002;184(1):37-45.
2002: Manning Christopher B; Cummins Andrew B; Jung Michael W; Berlanger Ingrid; Timblin Cynthia R; Palmer Cathy; Taatjes Douglas J; Hemenway David; Vacek Pamela; Mossman Brooke T
A mutant epidermal growth factor receptor targeted to lung epithelium inhibits asbestos-induced proliferation and proto-oncogene expression.
Cancer research 2002;62(15):4169-75.
2002: Lounsbury Karen M; Stern Maria; Taatjes Douglas; Jaken Susan; Mossman Brooke T
Increased localization and substrate activation of protein kinase C delta in lung epithelial cells following exposure to asbestos.
The American journal of pathology 2002;160(6):1991-2000.
2002: Ramos-Nino Maria E; Haegens Astrid; Shukla Arti; Mossman Brooke T
Role of mitogen-activated protein kinases (MAPK) in cell injury and proliferation by environmental particulates.
Molecular and cellular biochemistry 2002;234-235(1-2):111-8.
2002: Hubbard Andrea K; Timblin Cynthia R; Shukla Arti; Rincón Mercedes; Mossman Brooke T
Activation of NF-kappaB-dependent gene expression by silica in lungs of luciferase reporter mice.
American journal of physiology. Lung cellular and molecular physiology 2002;282(5):L968-75.
2002: Timblin Cynthia R; Shukla Arti; Berlanger Ingrid; BeruBe Kelly A; Churg Andrew; Mossman Brooke T
Ultrafine airborne particles cause increases in protooncogene expression and proliferation in alveolar epithelial cells.
Toxicology and applied pharmacology 2002;179(2):98-104.
2002: Manning Christopher B; Vallyathan Val; Mossman Brooke T
Diseases caused by asbestos: mechanisms of injury and disease development.
International immunopharmacology 2002;2(2-3):191-200.
2002: Mossman Brooke T; Gruenert Dieter C
SV40, growth factors, and mesothelioma: another piece of the puzzle.
American journal of respiratory cell and molecular biology 2002;26(2):167-70.
2001: Fukagawa N K; Li M; Timblin C R; Mossman B T
Modulation of cell injury and survival by high glucose and advancing age.
Free radical biology & medicine 2001;31(12):1560-9.
2001: Hubbard A K; Timblin C R; Rincon M; Mossman B T
Use of transgenic luciferase reporter mice to determine activation of transcription factors and gene expression by fibrogenic particles.
Chest 2001;120(1 Suppl):24S-25S.
2001: Timblin C; Robledo R; Rincon M; Cummins A; Pfeiffer L; Mossman B
Transgenic mouse models to determine the role of epidermal growth factor receptor in epithelial cell proliferation, apoptosis, and asbestosis.
Chest 2001;120(1 Suppl):22S-24S.
2001: Buder-Hoffmann S; Palmer C; Vacek P; Taatjes D; Mossman B
Different accumulation of activated extracellular signal-regulated kinases (ERK 1/2) and role in cell-cycle alterations by epidermal growth factor, hydrogen peroxide, or asbestos in pulmonary epithelial cells.
American journal of respiratory cell and molecular biology 2001;24(4):405-13.
2001: Shukla A; Timblin C R; Hubbard A K; Bravman J; Mossman B T
Silica-induced activation of c-Jun-NH2-terminal amino kinases, protracted expression of the activator protein-1 proto-oncogene, fra-1, and S-phase alterations are mediated via oxidative stress.
Cancer research 2001;61(5):1791-5.
2001: Driscoll K E; Howard B W; Carter J M; Janssen Y M; Mossman B T; Isfort R J
Mitochondrial-derived oxidants and quartz activation of chemokine gene expression.
Advances in experimental medicine and biology 2001;500():489-96.
2000: Shukla A; Timblin C; BeruBe K; Gordon T; McKinney W; Driscoll K; Vacek P; Mossman B T
Inhaled particulate matter causes expression of nuclear factor (NF)-kappaB-related genes and oxidant-dependent NF-kappaB activation in vitro.
American journal of respiratory cell and molecular biology 2000;23(2):182-7.
2000: Mossman B T
Signal transduction by oxidants: look who's talking.
Free radical biology & medicine 2000;28(9):1315-6.
2000: Jung M; Davis W P; Taatjes D J; Churg A; Mossman B T
Asbestos and cigarette smoke cause increased DNA strand breaks and necrosis in bronchiolar epithelial cells in vivo.
Free radical biology & medicine 2000;28(8):1295-9.
2000: Robledo R F; Buder-Hoffmann S A; Cummins A B; Walsh E S; Taatjes D J; Mossman B T
Increased phosphorylated extracellular signal-regulated kinase immunoreactivity associated with proliferative and morphologic lung alterations after chrysotile asbestos inhalation in mice.
The American journal of pathology 2000;156(4):1307-16.
2000: Murthy S S; Shen T; De Rienzo A; Lee W C; Ferriola P C; Jhanwar S C; Mossman B T; Filmus J; Testa J R
Expression of GPC3, an X-linked recessive overgrowth gene, is silenced in malignant mesothelioma.
Oncogene 2000;19(3):410-6.
2000: Fukagawa N K; Timblin C R; Buder-Hoffman S; Mossman B T
Strategies for evaluation of signaling pathways and transcription factors altered in aging.
Antioxidants & redox signaling 2000;2(3):379-89.
1999: Poynter M E; Janssen-Heininger Y M; Buder-Hoffmann S; Taatjes D J; Mossman B T
Measurement of oxidant-induced signal transduction proteins using cell imaging.
Free radical biology & medicine 1999;27(11-12):1164-72.
1999: Zanella C L; Timblin C R; Cummins A; Jung M; Goldberg J; Raabe R; Tritton T R; Mossman B T
Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis.
The American journal of physiology 1999;277(4 Pt 1):L684-93.
1999: Robledo R; Mossman B
Cellular and molecular mechanisms of asbestos-induced fibrosis.
Journal of cellular physiology 1999;180(2):158-66.
1999: Janssen-Heininger Y M; Macara I; Mossman B T
Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-kappaB: requirement of Ras/mitogen-activated protein kinases in the activation of NF-kappaB by oxidants.
American journal of respiratory cell and molecular biology 1999;20(5):942-52.
1999: Mossman B T
Environmental pathology: new directions and opportunities.
Toxicologic pathology 1999;27(2):180-6.
1998: Barchowsky A; Roussel R R; Krieser R J; Mossman B T; Treadwell M D
Expression and activity of urokinase and its receptor in endothelial and pulmonary epithelial cells exposed to asbestos.
Toxicology and applied pharmacology 1998;152(2):388-96.
1998: Janssen Y M; Driscoll K E; Timblin C R; Hassenbein D; Mossman B T
Modulation of mitochondrial gene expression in pulmonary epithelial cells exposed to oxidants.
Environmental health perspectives 1998;106 Suppl 5():1191-5.
1998: Driscoll K E; Carter J M; Howard B W; Hassenbein D; Janssen Y M; Mossman B T
Crocidolite activates NF-kappa B and MIP-2 gene expression in rat alveolar epithelial cells. Role of mitochondrial-derived oxidants.
Environmental health perspectives 1998;106 Suppl 5():1171-4.
1998: Timblin C; BeruBe K; Churg A; Driscoll K; Gordon T; Hemenway D; Walsh E; Cummins A B; Vacek P; Mossman B
Ambient particulate matter causes activation of the c-jun kinase/stress-activated protein kinase cascade and DNA synthesis in lung epithelial cells.
Cancer research 1998;58(20):4543-7.
1998: Timblin C R; Guthrie G D; Janssen Y W; Walsh E S; Vacek P; Mossman B T
Patterns of c-fos and c-jun proto-oncogene expression, apoptosis, and proliferation in rat pleural mesothelial cells exposed to erionite or asbestos fibers.
Toxicology and applied pharmacology 1998;151(1):88-97.
1998: Mossman B T; Churg A
Mechanisms in the pathogenesis of asbestosis and silicosis.
American journal of respiratory and critical care medicine 1998;157(5 Pt 1):1666-80.
1998: Quinlan T R; BeruBe K A; Hacker M P; Taatjes D J; Timblin C R; Goldberg J; Kimberley P; O'Shaughnessy P; Hemenway D; Torino J; Jimenez L A; Mossman B T
Mechanisms of asbestos-induced nitric oxide production by rat alveolar macrophages in inhalation and in vitro models.
Free radical biology & medicine 1998;24(5):778-88.
1998: Timblin C R; Janssen Y M; Goldberg J L; Mossman B T
GRP78, HSP72/73, and cJun stress protein levels in lung epithelial cells exposed to asbestos, cadmium, or H2O2.
Free radical biology & medicine 1998;24(4):632-42.
1998: Pache J C; Janssen Y M; Walsh E S; Quinlan T R; Zanella C L; Low R B; Taatjes D J; Mossman B T
Increased epidermal growth factor-receptor protein in a human mesothelial cell line in response to long asbestos fibers.
The American journal of pathology 1998;152(2):333-40.
1998: Fung H; Kow Y W; Van Houten B; Taatjes D J; Hatahet Z; Janssen Y M; Vacek P; Faux S P; Mossman B T
Asbestos increases mammalian AP-endonuclease gene expression, protein levels, and enzyme activity in mesothelial cells.
Cancer research 1998;58(2):189-94.
1997: Jiménez L A; Zanella C; Fung H; Janssen Y M; Vacek P; Charland C; Goldberg J; Mossman B T
Role of extracellular signal-regulated protein kinases in apoptosis by asbestos and H2O2.
The American journal of physiology 1997;273(5 Pt 1):L1029-35.
1997: Davis W P; Janssen Y M; Mossman B T; Taatjes D J
Simultaneous triple fluorescence detection of mRNA localization, nuclear DNA, and apoptosis in cultured cells using confocal scanning laser microscopy.
Histochemistry and cell biology 1997;108(4-5):307-11.
1997: Janssen Y M; Matalon S; Mossman B T
Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS.
The American journal of physiology 1997;273(4 Pt 1):L789-96.
1997: Mossman B T; Faux S; Janssen Y; Jimenez L A; Timblin C; Zanella C; Goldberg J; Walsh E; Barchowsky A; Driscoll K
Cell signaling pathways elicited by asbestos.
Environmental health perspectives 1997;105 Suppl 5():1121-5.
1997: Goldberg J L; Zanella C L; Janssen Y M; Timblin C R; Jimenez L A; Vacek P; Taatjes D J; Mossman B T
Novel cell imaging techniques show induction of apoptosis and proliferation in mesothelial cells by asbestos.
American journal of respiratory cell and molecular biology 1997;17(3):265-71.
1997: Janssen Y M; Driscoll K E; Howard B; Quinlan T R; Treadwell M; Barchowsky A; Mossman B T
Asbestos causes translocation of p65 protein and increases NF-kappa B DNA binding activity in rat lung epithelial and pleural mesothelial cells.
The American journal of pathology 1997;151(2):389-401.
1997: Fung H; Quinlan T R; Janssen Y M; Timblin C R; Marsh J P; Heintz N H; Taatjes D J; Vacek P; Jaken S; Mossman B T
Inhibition of protein kinase C prevents asbestos-induced c-fos and c-jun proto-oncogene expression in mesothelial cells.
Cancer research 1997;57(15):3101-5.
1997: Fung H; Kow Y W; Van Houten B; Mossman B T
Patterns of 8-hydroxydeoxyguanosine formation in DNA and indications of oxidative stress in rat and human pleural mesothelial cells after exposure to crocidolite asbestos.
Carcinogenesis 1997;18(4):825-32.
1996: Zanella C L; Posada J; Tritton T R; Mossman B T
Asbestos causes stimulation of the extracellular signal-regulated kinase 1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor.
Cancer research 1996;56(23):5334-8.
1996: Treadwell M D; Mossman B T; Barchowsky A
Increased neutrophil adherence to endothelial cells exposed to asbestos.
Toxicology and applied pharmacology 1996;139(1):62-70.
1996: BéruBé K A; Quinlan T R; Fung H; Magae J; Vacek P; Taatjes D J; Mossman B T
Apoptosis is observed in mesothelial cells after exposure to crocidolite asbestos.
American journal of respiratory cell and molecular biology 1996;15(1):141-7.
1996: BéruBé K A; Quinlan T R; Moulton G; Hemenway D; O'Shaughnessy P; Vacek P; Mossman B T
Comparative proliferative and histopathologic changes in rat lungs after inhalation of chrysotile or crocidolite asbestos.
Toxicology and applied pharmacology 1996;137(1):67-74.
1996: Mossman B T; Surinrut P; Brinton B T; Marsh J P; Heintz N H; Lindau-Shepard B; Shaffer J B
Transfection of a manganese-containing superoxide dismutase gene into hamster tracheal epithelial cells ameliorates asbestos-mediated cytotoxicity.
Free radical biology & medicine 1996;21(2):125-31.
1996: Mossman B T; Kamp D W; Weitzman S A
Mechanisms of carcinogenesis and clinical features of asbestos-associated cancers.
Cancer investigation 1996;14(5):466-80.
1995: Driscoll K E; Hassenbein D G; Carter J M; Kunkel S L; Quinlan T R; Mossman B T
TNF alpha and increased chemokine expression in rat lung after particle exposure.
Toxicology letters 1995;82-83():483-9.
1995: Quinlan T R; BéruBé K A; Marsh J P; Janssen Y M; Taishi P; Leslie K O; Hemenway D; O'Shaughnessy P T; Vacek P; Mossman B T
Patterns of inflammation, cell proliferation, and related gene expression in lung after inhalation of chrysotile asbestos.
The American journal of pathology 1995;147(3):728-39.
1995: Janssen Y M; Barchowsky A; Treadwell M; Driscoll K E; Mossman B T
Asbestos induces nuclear factor kappa B (NF-kappa B) DNA-binding activity and NF-kappa B-dependent gene expression in tracheal epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8458-62.
1995: Timblin C R; Janssen Y W; Mossman B T
Transcriptional activation of the proto-oncogene c-jun by asbestos and H2O2 is directly related to increased proliferation and transformation of tracheal epithelial cells.
Cancer research 1995;55(13):2723-6.
1995: Janssen Y M; Heintz N H; Mossman B T
Induction of c-fos and c-jun proto-oncogene expression by asbestos is ameliorated by N-acetyl-L-cysteine in mesothelial cells.
Cancer research 1995;55(10):2085-9.
1994: Quinlan T R; Marsh J P; Janssen Y M; Borm P A; Mossman B T
Oxygen radicals and asbestos-mediated disease.
Environmental health perspectives 1994;102 Suppl 10():107-10.
1994: Janssen Y M; Heintz N H; Marsh J P; Borm P J; Mossman B T
Induction of c-fos and c-jun proto-oncogenes in target cells of the lung and pleura by carcinogenic fibers.
American journal of respiratory cell and molecular biology 1994;11(5):522-30.
1994: Quinlan T R; Marsh J P; Janssen Y M; Leslie K O; Hemenway D; Vacek P; Mossman B T
Dose-responsive increases in pulmonary fibrosis after inhalation of asbestos.
American journal of respiratory and critical care medicine 1994;150(1):200-6.
1994: Quinlan T; Spivack S; Mossman B T
Regulation of antioxidant enzymes in lung after oxidant injury.
Environmental health perspectives 1994;102 Suppl 2():79-87.
1994: Janssen Y M; Marsh J P; Absher M P; Gabrielson E; Borm P J; Driscoll K; Mossman B T
Oxidant stress responses in human pleural mesothelial cells exposed to asbestos.
American journal of respiratory and critical care medicine 1994;149(3 Pt 1):795-802.
1994: Janssen Y M; Marsh J P; Driscoll K E; Borm P J; Oberdörster G; Mossman B T
Increased expression of manganese-containing superoxide dismutase in rat lungs after inhalation of inflammatory and fibrogenic minerals.
Free radical biology & medicine 1994;16(3):315-22.
1994: Marsh J P; Mossman B T; Driscoll K E; Schins R F; Borm P J
Effects of Aramid, a high strength synthetic fiber, on respiratory cells in vitro.
Drug and chemical toxicology 1994;17(2):75-92.
1993: Janssen Y M; Van Houten B; Borm P J; Mossman B T
Cell and tissue responses to oxidative damage.
Laboratory investigation; a journal of technical methods and pathology 1993;69(3):261-74.
1993: Heintz N H; Janssen Y M; Mossman B T
Persistent induction of c-fos and c-jun expression by asbestos.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3299-303.
1992: Holley J A; Janssen Y M; Mossman B T; Taatjes D J
Increased manganese superoxide dismutase protein in type II epithelial cells of rat lungs after inhalation of crocidolite asbestos or cristobalite silica.
The American journal of pathology 1992;141(2):475-85.
1992: Janssen Y M; Marsh J P; Absher M P; Hemenway D; Vacek P M; Leslie K O; Borm P J; Mossman B T
Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica.
The Journal of biological chemistry 1992;267(15):10625-30.
1991: Shull S; Heintz N H; Periasamy M; Manohar M; Janssen Y M; Marsh J P; Mossman B T
Differential regulation of antioxidant enzymes in response to oxidants.
The Journal of biological chemistry 1991;266(36):24398-403.
1991: Perderiset M; Marsh J P; Mossman B T
Activation of protein kinase C by crocidolite asbestos in hamster tracheal epithelial cells.
Carcinogenesis 1991;12(8):1499-502.
1991: Edmondson S W; Mossman B T
Alterations in keratin expression in hamster tracheal epithelial cells exposed to benzo[a]pyrene.
Carcinogenesis 1991;12(4):679-84.
1991: Marsh J P; Mossman B T
Role of asbestos and active oxygen species in activation and expression of ornithine decarboxylase in hamster tracheal epithelial cells.
Cancer research 1991;51(1):167-73.
1991: Mossman B T; Janssen Y M; Marsh J P; Sesko A; Shatos M A; Doherty J; Adler K B; Hemenway D; Mickey R; Vacek
Development and characterization of a rapid-onset rodent inhalation model of asbestosis for disease prevention.
Toxicologic pathology 1991;19(4 Pt 1):412-8.
1991: Petruska J M; Leslie K O; Mossman B T
Enhanced lipid peroxidation in lung lavage of rats after inhalation of asbestos.
Free radical biology & medicine 1991;11(4):425-32.
1990: Sesko A; Cabot M; Mossman B
Hydrolysis of inositol phospholipids precedes cellular proliferation in asbestos-stimulated tracheobronchial epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7385-9.
1990: Mossman B T
In vitro studies on the biologic effects of fibers: correlation with in vivo bioassays.
Environmental health perspectives 1990;88():319-22.
1990: Mossman B T; Marsh J P; Sesko A; Hill S; Shatos M A; Doherty J; Petruska J; Adler K B; Hemenway D; Mickey R
Inhibition of lung injury, inflammation, and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis.
The American review of respiratory disease 1990;141(5 Pt 1):1266-71.
1990: Petruska J M; Marsh J; Bergeron M; Mossman B T
Brief inhalation of asbestos compromises superoxide production in cells from bronchoalveolar lavage.
American journal of respiratory cell and molecular biology 1990;2(2):129-36.
1990: Mossman B T; Sesko A M
In vitro assays to predict the pathogenicity of mineral fibers.
Toxicology 1990;60(1-2):53-61.
1990: Mossman B T; Bignon J; Corn M; Seaton A; Gee J B
Asbestos: scientific developments and implications for public policy.
Science (New York, N.Y.) 1990;247(4940):294-301.
1990: Edmondson S W; Wu R; Mossman B T
Regulation of differentiation and keratin protein expression by vitamin A in primary cultures of hamster tracheal epithelial cells.
Journal of cellular physiology 1990;142(1):21-30.
1990: Petruska J M; Wong S H; Sunderman F W; Mossman B T
Detection of lipid peroxidation in lung and in bronchoalveolar lavage cells and fluid.
Free radical biology & medicine 1990;9(1):51-8.
1990: Janssen Y M; Marsh J P; Absher M; Borm P J; Mossman B T
Increases in endogenous antioxidant enzymes during asbestos inhalation in rats.
Free radical research communications 1990;11(1-3):53-8.
1989: Mossman B T; Gee J B
Asbestos-related diseases.
The New England journal of medicine 1989;320(26):1721-30.
1989: Mossman B T; Marsh J P
Evidence supporting a role for active oxygen species in asbestos-induced toxicity and lung disease.
Environmental health perspectives 1989;81():91-4.
1989: Sesko A M; Mossman B T
Sensitivity of hamster tracheal epithelial cells to asbestiform minerals modulated by serum and by transforming growth factor beta 1.
Cancer research 1989;49(10):2743-9.
1989: Cameron G; Woodworth C D; Edmondson S; Mossman B T
Mechanisms of asbestos-induced squamous metaplasia in tracheobronchial epithelial cells.
Environmental health perspectives 1989;80():101-8.
1989: Mossman B T; Hansen K; Marsh J P; Brew M E; Hill S; Bergeron M; Petruska J
Mechanisms of fibre-induced superoxide release from alveolar macrophages and induction of superoxide dismutase in the lungs of rats inhaling crocidolite.
IARC scientific publications 1989;(90):81-92.
1988: Marsh J P; Mossman B T
Mechanisms of induction of ornithine decarboxylase activity in tracheal epithelial cells by asbestiform minerals.
Cancer research 1988;48(3):709-14.
1987: Shatos M A; Doherty J M; Marsh J P; Mossman B T
Prevention of asbestos-induced cell death in rat lung fibroblasts and alveolar macrophages by scavengers of active oxygen species.
Environmental research 1987;44(1):103-16.
1987: Mossman B T; Marsh J P; Shatos M A; Doherty J; Gilbert R; Hill S
Implication of active oxygen species as second messengers of asbestos toxicity.
Drug and chemical toxicology 1987;10(1-2):157-80.
1986: Mossman B T; Gilbert R; Doherty J; Shatos M A; Marsh J; Cutroneo K
Cellular and molecular mechanisms of asbestosis.
Chest 1986;89(3 Suppl):160S-161S.
1986: Mossman B T; Marsh J P; Shatos M A
Alteration of superoxide dismutase activity in tracheal epithelial cells by asbestos and inhibition of cytotoxicity by antioxidants.
Laboratory investigation; a journal of technical methods and pathology 1986;54(2):204-12.
1986: Mossman B T; Marsh J P; Hardwick D; Gilbert R; Hill S; Sesko A; Shatos M; Doherty J; Weller A; Bergeron M
Approaches to prevention of asbestos-induced lung disease using polyethylene glycol (PEG)-conjugated catalase.
Journal of free radicals in biology & medicine 1986;2(5-6):335-8.

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