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Patrick Most

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Mirko Völkers; Nima Dolatabadi; Natalie Gude; Patrick Most; Mark A Sussman; David Hassel
Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish.
David Rohde; Henriette Brinks; Julia Ritterhoff; Gang Qui; Shumei Ren; Patrick Most
S100A1 gene therapy for heart failure: a novel strategy on the verge of clinical trials.
Philip W Raake; Walter J Koch; Patrick Most
Polymorphisms present in G-protein-coupled receptor kinases and their effect on β-blocker treatment.

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All Publications

2012: Mirko Völkers; Nima Dolatabadi; Natalie Gude; Patrick Most; Mark A Sussman; David Hassel
Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish.
Journal of cell science 2012;125(Pt 2):287-94.
2011: David Rohde; Henriette Brinks; Julia Ritterhoff; Gang Qui; Shumei Ren; Patrick Most
S100A1 gene therapy for heart failure: a novel strategy on the verge of clinical trials.
Journal of molecular and cellular cardiology 2011;50(5):777-84.
2011: Philip W Raake; Walter J Koch; Patrick Most
Polymorphisms present in G-protein-coupled receptor kinases and their effect on β-blocker treatment.
Pharmacogenomics 2011;12(3):295-7.
2011: Mirko Völkers; Christian Weidenhammer; Nicole Herzog; Gang Qiu; Kristin Spaich; Frederic von Wegner; Karsten Peppel; Oliver J Müller; Stefanie Schinkel; Joseph E Rabinowitz; Hans-Joerg Hippe; Henriette Brinks; Hugo A Katus; Walter J Koch; Andrea D Eckhart; Oliver Friedrich; Patrick Most
The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition.
Circulation research 2011;108(1):27-39.
2010: Henriette Brinks; Matthieu Boucher; Erhe Gao; J Kurt Chuprun; Stéphanie Pesant; Philip W Raake; Z Maggie Huang; Xiaoliang Wang; Gang Qiu; Anna Gumpert; David M Harris; Andrea D Eckhart; Patrick Most; Walter J Koch
Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms.
Circulation research 2010;107(9):1140-9.
2010: David Rohde; Julia Ritterhoff; Mirko Voelkers; Hugo A Katus; Thomas G Parker; Patrick Most
S100A1: a multifaceted therapeutic target in cardiovascular disease.
Journal of cardiovascular translational research 2010;3(5):525-37.
2010: Mirko Voelkers; Mareen Salz; Nicole Herzog; Derk Frank; Nima Dolatabadi; Norbert Frey; Natalie Gude; Oliver Friedrich; Walter J Koch; Hugo A Katus; Mark A Sussman; Patrick Most
Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes.
Journal of molecular and cellular cardiology 2010;48(6):1329-34.
2010: Mirko Völkers; David Rohde; Chelain Goodman; Patrick Most
S100A1: a regulator of striated muscle sarcoplasmic reticulum Ca2+ handling, sarcomeric, and mitochondrial function.
Journal of biomedicine & biotechnology 2010;2010():178614.
2010: Vasileios Askoxylakis; Christian Thieke; Sven T Pleger; Patrick Most; Judith Tanner; Katja Lindel; Hugo A Katus; Jürgen Debus; Marc Bischof
Long-term survival of cancer patients compared to heart failure and stroke: a systematic review.
BMC cancer 2010;10():105.
2009: Carolin Kraus; David Rohde; Christian Weidenhammer; Gang Qiu; Sven T Pleger; Mirko Voelkers; Melanie Boerries; Andrew Remppis; Hugo A Katus; Patrick Most
S100A1 in cardiovascular health and disease: closing the gap between basic science and clinical therapy.
Journal of molecular and cellular cardiology 2009;47(4):445-55.
2009: Mark Luedde; Ulrich Flögel; Maike Knorr; Christina Grundt; Hans-Joerg Hippe; Benedikt Brors; Derk Frank; Uta Haselmann; Claude Antony; Mirko Voelkers; Juergen Schrader; Patrick Most; Bjoern Lemmer; Hugo A Katus; Norbert Frey
Decreased contractility due to energy deprivation in a transgenic rat model of hypertrophic cardiomyopathy.
Journal of molecular medicine (Berlin, Germany) 2009;87(4):411-22.
2008: Brent R DeGeorge; Marc Rosenberg; Volker Eckstein; Erhe Gao; Nicole Herzog; Hugo A Katus; Walter J Koch; Norbert Frey; Patrick Most
BMP-2 and FGF-2 synergistically facilitate adoption of a cardiac phenotype in somatic bone marrow c-kit+/Sca-1+ stem cells.
Clinical and translational science 2008;1(2):116-25.
2008: Philip W Raake; Leif Erik Vinge; Erhe Gao; Matthieu Boucher; Giuseppe Rengo; Xiongwen Chen; Brent R DeGeorge; Scot Matkovich; Steven R Houser; Patrick Most; Andrea D Eckhart; Gerald W Dorn; Walter J Koch
G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.
Circulation research 2008;103(4):413-22.
2008: Matthieu Boucher; Stéphanie Pesant; Yong Hong Lei; Natasha Nanton; Patrick Most; Andrea D Eckhart; Walter J Koch; Erhe Gao
Simultaneous administration of insulin-like growth factor-1 and darbepoetin alfa protects the rat myocardium against myocardial infarction and enhances angiogenesis.
Clinical and translational science 2008;1(1):13-20.
2008: Sven T Pleger; David M Harris; Changguang Shan; Leif E Vinge; J Kurt Chuprun; Brett Berzins; Wiebke Pleger; Charles Druckman; Mirko Völkers; Jörg Heierhorst; Erik Øie; Andrew Remppis; Hugo A Katus; Rosario Scalia; Andrea D Eckhart; Walter J Koch; Patrick Most
Endothelial S100A1 modulates vascular function via nitric oxide.
Circulation research 2008;102(7):786-94.
2007: Sven T Pleger; Patrick Most; Walter J Koch
Recent findings into the potential of gene therapy to reverse heart failure.
Expert opinion on biological therapy 2007;7(12):1781-4.
2007: Patrick Most; Andrew Remppis; Sven T Pleger; Hugo A Katus; Walter J Koch
S100A1: a novel inotropic regulator of cardiac performance. Transition from molecular physiology to pathophysiological relevance.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(2):R568-77.
2007: Sven T Pleger; Patrick Most; Hugo A Katus
S100 proteins: a missing piece in the puzzle of heart failure?
Cardiovascular research 2007;75(1):1-2.
2007: Sven T Pleger; Matthieu Boucher; Patrick Most; Walter J Koch
Targeting myocardial beta-adrenergic receptor signaling and calcium cycling for heart failure gene therapy.
Journal of cardiac failure 2007;13(5):401-14.
2007: Melanie Boerries; Patrick Most; Jonathan R Gledhill; John E Walker; Hugo A Katus; Walter J Koch; Ueli Aebi; Cora-Ann Schoenenberger
Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes.
Molecular and cellular biology 2007;27(12):4365-73.
2007: Sven T Pleger; Patrick Most; Matthieu Boucher; Stephen Soltys; J Kurt Chuprun; Wiebke Pleger; Erhe Gao; Abhijit Dasgupta; Giuseppe Rengo; Andrew Remppis; Hugo A Katus; Andrea D Eckhart; Joseph E Rabinowitz; Walter J Koch
Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue.
Circulation 2007;115(19):2506-15.
2007: Mirko Völkers; Christopher M Loughrey; Niall Macquaide; Andrew Remppis; Brent R DeGeorge; Frederic V Wegner; Oliver Friedrich; Rainer H A Fink; Walter J Koch; Godfrey L Smith; Patrick Most
S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes.
Cell calcium 2007;41(2):135-43.
2007: Patrick Most; Walter J Koch
S100A1: a calcium-modulating inotropic prototype for future clinical heart failure therapy.
Future cardiology 2007;3(1):5-11.
2006: Sven T Pleger; Patrick Most; Beatrix Heidt; M Voelkers; J A Hata; Hugo A Katus; Andrew Remppis; Walter J Koch
S100A1 gene transfer in myocardium.
European journal of medical research 2006;11(10):418-22.
2006: Patrick Most; Hanna Seifert; Erhe Gao; Hajime Funakoshi; Mirko Völkers; Jörg Heierhorst; Andrew Remppis; Sven T Pleger; Brent R DeGeorge; Andrea D Eckhart; Arthur M Feldman; Walter J Koch
Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.
Circulation 2006;114(12):1258-68.
2006: Philipp Ehlermann; Kai Eggers; Angelika Bierhaus; Patrick Most; Dieter Weichenhan; Johannes Greten; Peter P Nawroth; Hugo A Katus; Andrew Remppis
Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products.
Cardiovascular diabetology 2006;5():6.
2005: Sven T Pleger; Andrew Remppis; Beatrix Heidt; Mirko Völkers; J Kurt Chuprun; Matthew Kuhn; Rui-Hai Zhou; Erhe Gao; Gabor Szabo; Dieter Weichenhan; Oliver J Müller; Andrea D Eckhart; Hugo A Katus; Walter J Koch; Patrick Most
S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(6):1120-9.
2005: Wolfgang Rottbauer; Steffen Just; Georgia Wessels; Nicole Trano; Patrick Most; Hugo A Katus; Mark C Fishman
VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart.
Genes & development 2005;19(13):1624-34.
2005: Patrick Most; Melanie Boerries; Carmen Eicher; Christopher Schweda; Mirko Völkers; Thilo Wedel; Stefan Söllner; Hugo A Katus; Andrew Remppis; Ueli Aebi; Walter J Koch; Cora-Ann Schoenenberger
Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes.
Journal of cell science 2005;118(Pt 2):421-31.
2005: Hui-Rong Liu; Erhe Gao; Aihua Hu; Ling Tao; Yan Qu; Patrick Most; Walter J Koch; Theodore A Christopher; Bernard L Lopez; Emad S Alnemri; Antonis S Zervos; Xin L Ma
Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion.
Circulation 2005;111(1):90-6.
2004: Patrick Most; Sven T Pleger; Mirko Völkers; Beatrix Heidt; Melanie Boerries; Dieter Weichenhan; Eva Löffler; Paul Janssen; Andrea D Eckhart; Jeffrey Martini; Matthew L Williams; Hugo A Katus; Andrew Remppis; Walter J Koch
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.
The Journal of clinical investigation 2004;114(11):1550-63.
2004: Patrick Most; Carmen Eicher; Mirko Völkers; Sven T Pleger; Hugo A Katus
Hope for a broken heart?
Trends in biotechnology 2004;22(10):487-9.
2004: Andrew Remppis; Sven T Pleger; Patrick Most; Jan Lindenkamp; Philipp Ehlermann; Christopher Schweda; Eva Löffler; Dieter Weichenhan; Wolfram Zimmermann; Thomas Eschenhagen; Walter J Koch; Hugo A Katus
S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts.
The journal of gene medicine 2004;6(4):387-94.
2003: Patrick Most; Melanie Boerries; Carmen Eicher; Christopher Schweda; Philipp Ehlermann; Sven T Pleger; Eva Loeffler; Walter J Koch; Hugo A Katus; Cora-Ann Schoenenberger; Andrew Remppis
Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2).
The Journal of biological chemistry 2003;278(48):48404-12.
2003: Patrick Most; Andrew Remppis; Sven T Pleger; Eva Löffler; Philipp Ehlermann; Juliane Bernotat; Christiane Kleuss; Jörg Heierhorst; Patricia Ruiz; Henning Witt; Peter Karczewski; Lan Mao; Howard A Rockman; Sandra J Duncan; Hugo A Katus; Walter J Koch
Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.
The Journal of biological chemistry 2003;278(36):33809-17.
2003: Patrick Most; Andrew Remppis; Cornelia Weber; Juliane Bernotat; Philipp Ehlermann; Sven T Pleger; Wolfgang G Kirsch; Martin Weber; Dietmar Uttenweiler; Godfrey L Smith; Hugo A Katus; Rainer H A Fink
The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers.
The Journal of biological chemistry 2003;278(29):26356-64.
2002: Patrick Most; Andrew Remppis; Hugo A Katus
Conditional AC type VI expression in the heart: relevant insights into function of inducible target gene expression.
Cardiovascular research 2002;56(2):181-3.
2002: Andrew Remppis; Patrick Most; Eva Löffler; Philipp Ehlermann; Juliane Bernotat; Sven T Pleger; Melanie Börries; Michael Reppel; Joachim Fischer; Walter J Koch; Godfrey Smith; Hugo A Katus
The small EF-hand Ca2+ binding protein S100A1 increases contractility and Ca2+ cycling in rat cardiac myocytes.
Basic research in cardiology 2002;97 Suppl 1():I56-62.
2001: Patrick Most; Juliane Bernotat; Philipp Ehlermann; Sven T Pleger; Michael Reppel; M Börries; F Niroomand; B Pieske; Paul Janssen; Thomas Eschenhagen; P Karczewski; Godfrey L Smith; Walter J Koch; Hugo A Katus; Andrew Remppis
S100A1: a regulator of myocardial contractility.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13889-94.
2000: P Ehlerman; Andrew Remppis; Patrick Most; Juliane Bernotat; C W Heizmann; Hugo A Katus
Purification of the Ca2+-binding protein S100A1 from myocardium and recombinant Escherichia coli.
Journal of chromatography. B, Biomedical sciences and applications 2000;737(1-2):39-45.
2000: Andrew Remppis; Philipp Ehlermann; Evangelos Giannitsis; T Greten; Patrick Most; Margit Müller-Bardorff; Hugo A Katus
Cardiac troponin T levels at 96 hours reflect myocardial infarct size: a pathoanatomical study.
Cardiology 2000;93(4):249-53.