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Lidia Mosyak

Research Profile

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X Ray Crystallography

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Heather H Shih; Chao Tu; Leeying Wu; Mostafa Ait-Zahra; Maya Arai; Bénédicte Autin; Joel Bard; Steven Braithwaite; Wei Cao; Christopher Corcoran; Orla Cunningham; Jo Ann Dumin; Brian J Fennell; Davinder Gill; Anne Klein; Eugenia Kouranova; Matthew Lambert; Edward R LaVallie; Sri Laxmanan; Anthony J Milici; Lidia Mosyak; Deirdre Ní Shúilleabháin; Janet E Paulsen; Renee Ramsey; William J J Finlay
An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition.
Yong Geng; Jonathan A Javitch; Julie Kniazeff; David L Malito; Lidia Mosyak; Jean-Philippe Pin; Matthias Quick; Dazhi Xiong; Svetlana Burmakina; Martin Bush; Yan Chen; Qing R Fan
Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2.
Xiaotian Zhong; Martin Allen; Cecilia Cooley; Z Sean Juo; Ravi Kumar; Lidia Mosyak; Ella Presman; Nicole Resendes; Nilufer Seth; William S Somers; Mark Stahl; Ron Kriz
Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: molecular insights and effector modulation of N-acetylglucosaminyltransferase I.

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All Publications

2012: Heather H Shih; Chao Tu; Leeying Wu; Mostafa Ait-Zahra; Maya Arai; Bénédicte Autin; Joel Bard; Steven Braithwaite; Wei Cao; Christopher Corcoran; Orla Cunningham; Jo Ann Dumin; Brian J Fennell; Davinder Gill; Anne Klein; Eugenia Kouranova; Matthew Lambert; Edward R LaVallie; Sri Laxmanan; Anthony J Milici; Lidia Mosyak; Deirdre Ní Shúilleabháin; Janet E Paulsen; Renee Ramsey; William J J Finlay
An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition.
The Journal of biological chemistry 2012;287(53):44425-34.
2012: Yong Geng; Jonathan A Javitch; Julie Kniazeff; David L Malito; Lidia Mosyak; Jean-Philippe Pin; Matthias Quick; Dazhi Xiong; Svetlana Burmakina; Martin Bush; Yan Chen; Qing R Fan
Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2.
Nature neuroscience 2012;15(7):970-8.
2012: Xiaotian Zhong; Martin Allen; Cecilia Cooley; Z Sean Juo; Ravi Kumar; Lidia Mosyak; Ella Presman; Nicole Resendes; Nilufer Seth; William S Somers; Mark Stahl; Ron Kriz
Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: molecular insights and effector modulation of N-acetylglucosaminyltransferase I.
Biotechnology and bioengineering 2012;109(7):1723-34.
2010: Franklin J Moy; Arthur Lee; Lori Krim Gavrin; Zhang Bao Xu; Annette Sievers; Elizabeth Kieras; Wayne Stochaj; Lidia Mosyak; John McKew; Désirée H H Tsao
Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance.
Journal of medicinal chemistry 2010;53(3):1238-49.
2009: Lisa M Havran; Dan C Chong; Wayne E Childers; Paul J Dollings; Arlene Dietrich; Boyd L Harrison; Vasilios Marathias; Gregory Tawa; Ann Aulabaugh; Rebecca Cowling; Bhupesh Kapoor; Weixin Xu; Lidia Mosyak; Franklin Moy; Wah-Tung Hum; Andrew Wood; Albert J Robichaud
3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3.
Bioorganic & medicinal chemistry 2009;17(22):7755-68.
2009: Xiaotian Zhong; Jennifer Pocas; Yan Liu; Paul W Wu; Lidia Mosyak; Will Somers; Ron Kriz
Swift residue-screening identifies key N-glycosylated asparagines sufficient for surface expression of neuroglycoprotein Lingo-1.
FEBS letters 2009;583(6):1034-8.
2009: Andrea M Olland; James Strand; Eleonora Presman; Robert Czerwinski; Diane Joseph-McCarthy; Rustem Krykbaev; Gerhard Schlingmann; Rajiv Chopra; Laura Lin; Margaret Fleming; Ron Kriz; Mark Stahl; William Somers; Lori Fitz; Lidia Mosyak
Triad of polar residues implicated in pH specificity of acidic mammalian chitinase.
Protein science : a publication of the Protein Society 2009;18(3):569-78.
2008: Xiaotian Zhong; Madhavan Buddha; Guido Guidotti; Ron Kriz; Will Somers; Lidia Mosyak
Expression, purification and crystallization of the ecto-enzymatic domain of rat E-NTPDase1 CD39.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 11):1063-5.
2008: Lidia Mosyak; Katy E Georgiadis; Tania Shane; Kristine Svenson; Tracy Hebert; Thomas McDonagh; Stewart Mackie; Stephane Olland; Laura Lin; Xiaotian Zhong; Ron Kriz; Erica L Reifenberg; Lisa A Collins-Racie; Chris Corcoran; Bethany Freeman; Richard Zollner; Tod Marvell; Matthew Vera; Phaik-Eng Sum; Edward R LaVallie; Mark L Stahl; William Somers
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein science : a publication of the Protein Society 2008;17(1):16-21.
2007: Lidia Mosyak; Z Xu; Diane Joseph-McCarthy; N Brooijmans; William S Somers; Divya Chaudhary
Structure-based optimization of PKCtheta inhibitors.
Biochemical Society transactions 2007;35(Pt 5):1027-31.
2006: Desirée H H Tsao; Alan G Sutherland; Lee D Jennings; Yuanhong Li; Thomas S Rush; Juan Alvarez; Weidong Ding; Elizabeth G Dushin; Russell G Dushin; Steven A Haney; Cynthia H Kenny; A Karl Malakian; Ramaswamy Nilakantan; Lidia Mosyak
Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
Bioorganic & medicinal chemistry 2006;14(23):7953-61.
2006: Lidia Mosyak; Andrew Wood; Brian Dwyer; Madhavan Buddha; Mark Johnson; Ann Aulabaugh; Xiaotian Zhong; Eleonora Presman; Susan Benard; Kerry Kelleher; James Wilhelm; Mark L Stahl; Ron Kriz; Ying Gao; Zixuan Cao; Huai-Ping Ling; Menelas Pangalos; Frank S Walsh; William S Somers
The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition.
The Journal of biological chemistry 2006;281(47):36378-90.
2006: Robert J Steffan; Edward Matelan; Mark A Ashwell; William J Moore; William R Solvibile; Eugene Trybulski; Christopher C Chadwick; Susan Chippari; Thomas Kenney; Richard Winneker; Amy Eckert; Lisa Borges-Marcucci; Steven J Adelman; Zhang Xu; Lidia Mosyak; Douglas C Harnish
Control of chronic inflammation with pathway selective estrogen receptor ligands.
Current topics in medicinal chemistry 2006;6(2):103-11.
2005: Thomas S Rush; J Andrew Grant; Lidia Mosyak; Anthony Nicholls
A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction.
Journal of medicinal chemistry 2005;48(5):1489-95.
2004: Robert J Steffan; Edward Matelan; Mark A Ashwell; William J Moore; William R Solvibile; Eugene Trybulski; Christopher C Chadwick; Susan Chippari; Thomas Kenney; Amy Eckert; Lisa Borges-Marcucci; James Carl Keith; Zhang Xu; Lidia Mosyak; Douglas C Harnish
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis.
Journal of medicinal chemistry 2004;47(26):6435-8.
2004: Zhang B Xu; Divya Chaudhary; Stephane Olland; Scott Wolfrom; Robert Czerwinski; Karl Malakian; Laura Lin; Mark L Stahl; Diane Joseph-McCarthy; Christina Benander; Lori Fitz; Rita Greco; William S Somers; Lidia Mosyak
Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).
The Journal of biological chemistry 2004;279(48):50401-9.
2004: Lee D Jennings; Kenneth W Foreman; Thomas S Rush; Desirée H H Tsao; Lidia Mosyak; Scott L Kincaid; Mohani N Sukhdeo; Alan G Sutherland; Weidong Ding; Cynthia Hess Kenny; Chantel L Sabus; Hanlan Liu; Elizabeth G Dushin; Soraya L Moghazeh; Pornpen Labthavikul; Peter J Petersen; Margareta Tuckman; Steven A Haney; Alexey Ruzin
Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction.
Bioorganic & medicinal chemistry 2004;12(19):5115-31.
2004: John J Dumas; Ravindra Kumar; Thomas McDonagh; Francis Sullivan; Mark L Stahl; William S Somers; Lidia Mosyak
Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations.
The Journal of biological chemistry 2004;279(22):23327-34.
2004: Lee D Jennings; Kenneth W Foreman; Thomas S Rush; Desirée H H Tsao; Lidia Mosyak; Yuanhong Li; Mohani N Sukhdeo; Weidong Ding; Elizabeth G Dushin; Cynthia Hess Kenny; Soraya L Moghazeh; Peter J Petersen; Alexey Ruzin; Margareta Tuckman; Alan G Sutherland
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction.
Bioorganic & medicinal chemistry letters 2004;14(6):1427-31.
2004: Robert H Scannevin; KeWei Wang; Flora Jow; Jennifer Megules; David C Kopsco; Wade Edris; Karen C Carroll; Qiang Lü; Weixin Xu; Zhangbao Xu; Alan H Katz; Stephane Olland; Laura Lin; Meggin Taylor; Mark L Stahl; Karl Malakian; William S Somers; Lidia Mosyak; Mark Bowlby; Pranab K Chanda; Kenneth J Rhodes
Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.
Neuron 2004;41(4):587-98.
2003: Cynthia Hess Kenny; Weidong Ding; Kerry Kelleher; Susan Benard; Elizabeth G Dushin; Alan G Sutherland; Lidia Mosyak; Ron Kriz; George Ellestad
Development of a fluorescence polarization assay to screen for inhibitors of the FtsZ/ZipA interaction.
Analytical biochemistry 2003;323(2):224-33.
2003: Alan G Sutherland; Juan Alvarez; Weidong Ding; Kenneth W Foreman; Cynthia Hess Kenny; Pornpen Labthavikul; Lidia Mosyak; Peter J Petersen; Thomas S Rush; Alexey Ruzin; Desirée H H Tsao; Karen L Wheless
Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.
Organic & biomolecular chemistry 2003;1(23):4138-40.
2003: John J Dumas; Ravindra Kumar; Jasbir Seehra; William S Somers; Lidia Mosyak
Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation.
Science (New York, N.Y.) 2003;301(5630):222-6.
2003: Kathryn W Underwood; Kevin D Parris; Elizabeth Federico; Lidia Mosyak; Robert Czerwinski; Tania Shane; Meggin Taylor; Kristine Svenson; Yan Liu; Chu-Lai Hsiao; Scott Wolfrom; Michelle Maguire; Karl Malakian; Jean-Baptiste Telliez; Lih-Ling Lin; Ron Kriz; Jasbir Seehra; William S Somers; Mark L Stahl
Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme.
Structure (London, England : 1993) 2003;11(6):627-36.
2002: efstratios stratikos; Lidia Mosyak; Dennis Zaller; Don C Wiley
Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis.
The Journal of experimental medicine 2002;196(2):173-83.
2001: C C Stamper; Y Zhang; James F Tobin; David V Erbe; Shinji Ikemizu; Simon J Davis; Mark L Stahl; Jasbir Seehra; William S Somers; Lidia Mosyak
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.
Nature 2001;410(6828):608-11.
2000: Franklin J Moy; E Glasfeld; Lidia Mosyak; Robert Powers
Solution structure of ZipA, a crucial component of Escherichia coli cell division.
Biochemistry 2000;39(31):9146-56.
2000: Lidia Mosyak; Y Zhang; E Glasfeld; Steven A Haney; Mark L Stahl; Jasbir Seehra; William S Somers
The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography.
The EMBO journal 2000;19(13):3179-91.
1999: QR Fan; Lidia Mosyak; David N Garboczi; CC Winter; Nicolai Wagtmann; Eric O Long; Don C Wiley
Structure of a human natural killer cell inhibitory receptor.
Transplantation proceedings 1999;31(4):1871-2.
1998: Lidia Mosyak; Dennis Zaller; Don C Wiley
The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation.
Immunity 1998;9(3):377-83.
1997: QR Fan; Lidia Mosyak; CC Winter; Nicolai Wagtmann; Eric O Long; Don C Wiley
Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors.
Nature 1997;389(6646):96-100.