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Hozumi Motohashi

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Keiko Nohara; Takehiro Suzuki; Kana Ao; Hikari Murai; Yoshimi Miyamoto; Kaoru Inouye; Xiaoqing Pan; Hozumi Motohashi; Yoshiaki Fujii-Kuriyama; Masayuki Yamamoto; Chiharu Tohyama
Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-gamma production in mice but does not suppress T(h)2-cytokine production or antibody production.
Takafumi Suzuki; Vincent P Kelly; Hozumi Motohashi; Osamu Nakajima; Satoru Takahashi; Susumu Nishimura; Masayuki Yamamoto
Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2.
Tomonori Hosoya; Nobuhiko Harada; Junsei Mimura; Hozumi Motohashi; Satoru Takahashi; Osamu Nakajima; Masanobu Morita; Shimako Kawauchi; Masayuki Yamamoto; Yoshiaki Fujii-Kuriyama
Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice.

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All Publications

2009: Keiko Nohara; Takehiro Suzuki; Kana Ao; Hikari Murai; Yoshimi Miyamoto; Kaoru Inouye; Xiaoqing Pan; Hozumi Motohashi; Yoshiaki Fujii-Kuriyama; Masayuki Yamamoto; Chiharu Tohyama
Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-gamma production in mice but does not suppress T(h)2-cytokine production or antibody production.
International immunology 2009;21(7):769-77.
2008: Takafumi Suzuki; Vincent P Kelly; Hozumi Motohashi; Osamu Nakajima; Satoru Takahashi; Susumu Nishimura; Masayuki Yamamoto
Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2.
The Journal of biological chemistry 2008;283(4):2021-30.
2008: Tomonori Hosoya; Nobuhiko Harada; Junsei Mimura; Hozumi Motohashi; Satoru Takahashi; Osamu Nakajima; Masanobu Morita; Shimako Kawauchi; Masayuki Yamamoto; Yoshiaki Fujii-Kuriyama
Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice.
Biochemical and biophysical research communications 2008;365(3):562-7.
2007: Momoko Kimura; Tae Yamamoto; Jianyong Zhang; Ken Itoh; Motoki Kyo; Terue Kamiya; Hiroyuki Aburatani; Fumiki Katsuoka; hirofumi kurokawa; Toshiyuki Tanaka; Hozumi Motohashi; Masayuki Yamamoto
Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer.
The Journal of biological chemistry 2007;282(46):33681-90.
2007: Jianyong Zhang; Tomonori Hosoya; Atsushi Maruyama; Keizo Nishikawa; Jonathan M Maher; Tsutomu Ohta; Hozumi Motohashi; Akiyoshi Fukamizu; Shigeki Shibahara; Ken Itoh; Masayuki Yamamoto
Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes.
The Biochemical journal 2007;404(3):459-66.
2007: Hozumi Motohashi; Masayuki Yamamoto
Carcinogenesis and transcriptional regulation through Maf recognition elements.
Cancer science 2007;98(2):135-9.
2006: Harumi Y Mukai; Hozumi Motohashi; Osamu Ohneda; Norio Suzuki; Masumi Nagano; Masayuki Yamamoto
Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation.
Molecular and cellular biology 2006;26(21):7953-65.
2006: Hozumi Motohashi; Fumiki Katsuoka; Chika Miyoshi; Yasuhiro Uchimura; Hisato Saitoh; Claire Francastel; James Douglas Engel; Masayuki Yamamoto
MafG sumoylation is required for active transcriptional repression.
Molecular and cellular biology 2006;26(12):4652-63.
2006: Tae Yamamoto; Motoki Kyo; Terue Kamiya; Toshiyuki Tanaka; James Douglas Engel; Hozumi Motohashi; Masayuki Yamamoto
Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(6):575-91.
2006: Hiromi Okawa; Hozumi Motohashi; Akira Kobayashi; Hiroyuki Aburatani; Thomas W Kensler; Masayuki Yamamoto
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.
Biochemical and biophysical research communications 2006;339(1):79-88.
2005: Masafumi Tauchi; Azumi Hida; Takaaki Negishi; Fumiki Katsuoka; Shuhei Noda; Junsei Mimura; Tomonori Hosoya; Akinori Yanaka; Hiroyuki Aburatani; Yoshiaki Fujii-Kuriyama; Hozumi Motohashi; Masayuki Yamamoto
Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions.
Molecular and cellular biology 2005;25(21):9360-8.
2005: Fumiki Katsuoka; Hozumi Motohashi; Tetsuro Ishii; Hiroyuki Aburatani; James Douglas Engel; Masayuki Yamamoto
Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes.
Molecular and cellular biology 2005;25(18):8044-51.
2005: Keiko Nohara; Xiaoqing Pan; Shin-ichi Tsukumo; Azumi Hida; Tomohiro Ito; Haruko Nagai; Kaoru Inouye; Hozumi Motohashi; Masayuki Yamamoto; Yoshiaki Fujii-Kuriyama; Chiharu Tohyama
Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2770-7.
2005: Fumiki Katsuoka; Hozumi Motohashi; James Douglas Engel; Masayuki Yamamoto
Nrf2 transcriptionally activates the mafG gene through an antioxidant response element.
The Journal of biological chemistry 2005;280(6):4483-90.
2004: Hozumi Motohashi; Masayuki Yamamoto
Nrf2-Keap1 defines a physiologically important stress response mechanism.
Trends in molecular medicine 2004;10(11):549-57.
2004: Tae Yamamoto; Keigyou Yoh; Akira Kobayashi; Yukio Ishii; Shigeo Kure; Akio Koyama; Tohru Sakamoto; Kiyohisa Sekizawa; Hozumi Motohashi; Masayuki Yamamoto
Identification of polymorphisms in the promoter region of the human NRF2 gene.
Biochemical and biophysical research communications 2004;321(1):72-9.
2004: Tomohiro Ito; Shin-ichi Tsukumo; Norio Suzuki; Hozumi Motohashi; Masayuki Yamamoto; Yoshiaki Fujii-Kuriyama; Junsei Mimura; Tien-Min Lin; Richard E Peterson; Chiharu Tohyama; Keiko Nohara
A constitutively active arylhydrocarbon receptor induces growth inhibition of jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest.
The Journal of biological chemistry 2004;279(24):25204-10.
2004: Hozumi Motohashi; Fumiki Katsuoka; James Douglas Engel; Masayuki Yamamoto
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6379-84.
2003: Norio Suzuki; Naruyoshi Suwabe; Osamu Ohneda; Naoshi Obara; Shigehiko Imagawa; Xiaoqing Pan; Hozumi Motohashi; Masayuki Yamamoto
Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levels.
Blood 2003;102(10):3575-83.
2003: Nobunao Wakabayashi; Ken Itoh; Junko Wakabayashi; Hozumi Motohashi; Shuhei Noda; Satoru Takahashi; Sumihisa Imakado; Tomoe Kotsuji; Fujio Otsuka; Dennis R Roop; Takanori Harada; James Douglas Engel; Masayuki Yamamoto
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.
Nature genetics 2003;35(3):238-45.
2003: Hozumi Motohashi
[Small Maf proteins as transcription factors regulating maturation and maintenance of the cell].
Seikagaku. The Journal of Japanese Biochemical Society 2003;75(9):1193-201.
2003: Takashi Moriguchi; Hozumi Motohashi; Tomonori Hosoya; Osamu Nakajima; Satoru Takahashi; Seiichiroh Ohsako; Yasunobu Aoki; Noriko Nishimura; Chiharu Tohyama; Yoshiaki Fujii-Kuriyama; Masayuki Yamamoto
Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5652-7.
2003: Shuhei Noda; Nobuhiko Harada; Azumi Hida; Yoshiaki Fujii-Kuriyama; Hozumi Motohashi; Masayuki Yamamoto
Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse.
Biochemical and biophysical research communications 2003;303(1):105-11.
2003: Fumiki Katsuoka; Hozumi Motohashi; Yuna Tamagawa; Shigeo Kure; Kazuhiko Igarashi; James Douglas Engel; Masayuki Yamamoto
Small Maf compound mutants display central nervous system neuronal degeneration, aberrant transcription, and Bach protein mislocalization coincident with myoclonus and abnormal startle response.
Molecular and cellular biology 2003;23(4):1163-74.
2002: Hozumi Motohashi; Tania O'Connor; Fumiki Katsuoka; James Douglas Engel; Masayuki Yamamoto
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors.
Gene 2002;294(1-2):1-12.
2001: Keigyou Yoh; T Sugawara; Hozumi Motohashi; Y Takahama; A Koyama; Masayuki Yamamoto; Satoru Takahashi
Transgenic over-expression of MafK suppresses T cell proliferation and function in vivo.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(12):1055-66.
2000: Hozumi Motohashi; Fumiki Katsuoka; Jordan A Shavit; James Douglas Engel; Masayuki Yamamoto
Positive or negative MARE-dependent transcriptional regulation is determined by the abundance of small Maf proteins.
Cell 2000;103(6):865-75.
2000: Fumiki Katsuoka; Hozumi Motohashi; K Onodera; Naruyoshi Suwabe; James Douglas Engel; Masayuki Yamamoto
One enhancer mediates mafK transcriptional activation in both hematopoietic and cardiac muscle cells.
The EMBO journal 2000;19(12):2980-91.
2000: Hozumi Motohashi
[Small Maf proteins in bZip transcription factor net-work].
Seikagaku. The Journal of Japanese Biochemical Society 2000;72(4):291-5.
2000: K Onodera; Jordan A Shavit; Hozumi Motohashi; Masayuki Yamamoto; James Douglas Engel
Perinatal synthetic lethality and hematopoietic defects in compound mafG::mafK mutant mice.
The EMBO journal 2000;19(6):1335-45.
1999: K Onodera; Jordan A Shavit; Hozumi Motohashi; Fumiki Katsuoka; J E Akasaka; James Douglas Engel; Masayuki Yamamoto
Characterization of the murine mafF gene.
The Journal of biological chemistry 1999;274(30):21162-9.
1998: Hozumi Motohashi; J Ohta; James Douglas Engel; Masayuki Yamamoto
A core region of the mafK gene IN promoter directs neurone-specific transcription in vivo.
Genes to cells : devoted to molecular & cellular mechanisms 1998;3(10):671-84.
1998: Jordan A Shavit; Hozumi Motohashi; K Onodera; J Akasaka; Masayuki Yamamoto; James Douglas Engel
Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice.
Genes & development 1998;12(14):2164-74.
1997: Hozumi Motohashi; Jordan A Shavit; Kazuhiko Igarashi; Masayuki Yamamoto; James Douglas Engel
The world according to Maf.
Nucleic acids research 1997;25(15):2953-59.
1997: Satoru Takahashi; K Onodera; Hozumi Motohashi; Naruyoshi Suwabe; Norio Hayashi; N Yanai; Y Nabesima; Masayuki Yamamoto
Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene.
The Journal of biological chemistry 1997;272(19):12611-5.
1994: Z Yang; L Gu; P H Romeo; D Bories; Hozumi Motohashi; M Yamamoto; James Douglas Engel
Human GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domains.
Molecular and cellular biology 1994;14(3):2201-12.