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Helen Mott

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Anthony Fitzpatrick; Robert G Griffin; Christopher Jaroniec; Tuomas P J Knowles; Vladimir Ladizhansky; Cait E MacPhee; Helen R Mott; Shirley A Müller; Elena V Orlova; Helen R Saibil; Michele Vendruscolo; Luchun Wang; Christopher Waudby; Vikram S Bajaj; Marvin J Bayro; Marc A Caporini; Daniel K Clare; Alfonso De Simone; Galia T Debelouchina; Christopher M Dobson
Atomic structure and hierarchical assembly of a cross-β amyloid fibril.
Karthik V Rajasekar; Louise J Campbell; Daniel Nietlispach; Darerca Owen; Helen R Mott
1H, 13C and 15N resonance assignments of the GTPase-activating (GAP) and Ral binding domains (GBD) of RLIP76 (RalBP1).
Catherine L Hutchinson; Peter N Lowe; Stephen H McLaughlin; Helen R Mott; Darerca Owen
Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.

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All Publications

2013: Anthony Fitzpatrick; Robert G Griffin; Christopher Jaroniec; Tuomas P J Knowles; Vladimir Ladizhansky; Cait E MacPhee; Helen R Mott; Shirley A Müller; Elena V Orlova; Helen R Saibil; Michele Vendruscolo; Luchun Wang; Christopher Waudby; Vikram S Bajaj; Marvin J Bayro; Marc A Caporini; Daniel K Clare; Alfonso De Simone; Galia T Debelouchina; Christopher M Dobson
Atomic structure and hierarchical assembly of a cross-β amyloid fibril.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(14):5468-73.
2012: Karthik V Rajasekar; Louise J Campbell; Daniel Nietlispach; Darerca Owen; Helen R Mott
1H, 13C and 15N resonance assignments of the GTPase-activating (GAP) and Ral binding domains (GBD) of RLIP76 (RalBP1).
Biomolecular NMR assignments 2012;6(2):119-22.
2011: Catherine L Hutchinson; Peter N Lowe; Stephen H McLaughlin; Helen R Mott; Darerca Owen
Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.
Biochemistry 2011;50(14):2860-9.
2010: R Brynmor Fenwick; Louise J Campbell; Karthik Rajasekar; Sunil Prasannan; Daniel Nietlispach; Jacques Camonis; Darerca Owen; Helen R Mott
The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction.
Structure (London, England : 1993) 2010;18(8):985-95.
2010: Antoine Gautier; Helen R Mott; Mark J Bostock; John P Kirkpatrick; Daniel Nietlispach
Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy.
Nature structural & molecular biology 2010;17(6):768-74.
2009: Laura K Bailey; Louise J Campbell; Katrina A Evetts; Keily Littlefield; Eeson Rajendra; Daniel Nietlispach; Darerca Owen; Helen R Mott
1H, 13C and 15N resonance assignments for Binder of Arl2, BART.
Biomolecular NMR assignments 2009;3(1):33-6.
2009: R Bryn Fenwick; Sunil Prasannan; Louise J Campbell; Daniel Nietlispach; Katrina A Evetts; Jacques Camonis; Helen R Mott; Darerca Owen
Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding.
Biochemistry 2009;48(10):2192-206.
2009: Laura K Bailey; Louise J Campbell; Katrina A Evetts; Keily Littlefield; Eeson Rajendra; Daniel Nietlispach; Darerca Owen; Helen R Mott
The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function.
The Journal of biological chemistry 2009;284(2):992-9.
2008: R Bryn Fenwick; Sunil Prasannan; Louise J Campbell; Katrina A Evetts; Daniel Nietlispach; Darerca Owen; Helen R Mott
Resonance assignments for the RLIP76 Ral binding domain in its free form and in complex with the small G protein RalB.
Biomolecular NMR assignments 2008;2(2):191-4.
2008: R Bryn Fenwick; Sunil Prasannan; Louise J Campbell; Katrina A Evetts; Daniel Nietlispach; Darerca Owen; Helen R Mott
1H, 13C and 15N resonance assignments for the active conformation of the small G protein RalB in complex with its effector RLIP76.
Biomolecular NMR assignments 2008;2(2):179-82.
2008: Nicola G Jones; Daniel Nietlispach; Reuben Sharma; david burke; Isobel Eyres; Marsilius Mues; Helen R Mott; Mary Carrington
Structure of a glycosylphosphatidylinositol-anchored domain from a trypanosome variant surface glycoprotein.
The Journal of biological chemistry 2008;283(6):3584-93.
2008: Rakhee Modha; Louise J Campbell; Daniel Nietlispach; Heeran R Buhecha; Darerca Owen; Helen R Mott
The Rac1 polybasic region is required for interaction with its effector PRK1.
The Journal of biological chemistry 2008;283(3):1492-500.
2008: Darerca Owen; Louise J Campbell; Keily Littlefield; Katrina A Evetts; Zhigang Li; David B Sacks; Peter N Lowe; Helen R Mott
The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes.
The Journal of biological chemistry 2008;283(3):1692-704.
2007: Tuomas P J Knowles; Anthony Fitzpatrick; Sarah Meehan; Helen R Mott; Michele Vendruscolo; Christopher M Dobson; Mark E Welland
Role of intermolecular forces in defining material properties of protein nanofibrils.
Science (New York, N.Y.) 2007;318(5858):1900-3.
2007: Andrea E Elliot-Smith; Darerca Owen; Helen R Mott; Peter N Lowe
Double mutant cycle thermodynamic analysis of the hydrophobic Cdc42-ACK protein-protein interaction.
Biochemistry 2007;46(49):14087-99.
2007: Sunil Prasannan; R Bryn Fenwick; Louise J Campbell; Katrina A Evetts; Daniel Nietlispach; Darerca Owen; Helen R Mott
1H, 13C and 15N resonance assignments for the small G protein RalB in its active conformation.
Biomolecular NMR assignments 2007;1(1):147-9.
2007: O Clyde Hutchinson; Kim Picozzi; Nicola G Jones; Helen R Mott; Reuben Sharma; Susan C Welburn; Mary Carrington
Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific.
BMC genomics 2007;8():234.
2005: Andrea E Elliot-Smith; Helen R Mott; Peter N Lowe; Ernest D Laue; Darerca Owen
Specificity determinants on Cdc42 for binding its effector protein ACK.
Biochemistry 2005;44(37):12373-83.
2005: Helen R Mott; Daniel Nietlispach; Katrina A Evetts; Darerca Owen
Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK).
Biochemistry 2005;44(33):10977-83.
2005: Anasuya Chattopadhyay; Nicola G Jones; Daniel Nietlispach; Peter R Nielsen; H Paul Voorheis; Helen R Mott; Mary Carrington
Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2.
The Journal of biological chemistry 2005;280(8):7228-35.
2004: Andie D Collinson; S W Annie Bligh; Debbie L Graham; Helen R Mott; Peter A Chalk; Nadia Korniotis; Peter N Lowe
Fluorescence properties of green fluorescent protein FRET pairs concatenated with the small G protein, Rac, and its interacting domain of the kinase, p21-activated kinase.
Assay and drug development technologies 2004;2(6):659-73.
2004: Abarna Thiru; Daniel Nietlispach; Helen R Mott; Mitsuru Okuwaki; Debbie Lyon; Peter R Nielsen; Miriam Hirshberg; Alain Verreault; Natalia V Murzina; Ernest D Laue
Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin.
The EMBO journal 2004;23(3):489-99.
2004: Simon J Grimshaw; Helen R Mott; Katherine Stott; Peter R Nielsen; Katrina A Evetts; Louise J Hopkins; Daniel Nietlispach; Darerca Owen
Structure of the sterile alpha motif (SAM) domain of the Saccharomyces cerevisiae mitogen-activated protein kinase pathway-modulating protein STE50 and analysis of its interaction with the STE11 SAM.
The Journal of biological chemistry 2004;279(3):2192-201.
2004: Daniel Nietlispach; Helen R Mott; Katherine Stott; Peter R Nielsen; Abarna Thiru; Ernest D Laue
Structure determination of protein complexes by NMR.
Methods in molecular biology (Clifton, N.J.) 2004;278():255-88.
2003: Darerca Owen; Peter N Lowe; Daniel Nietlispach; C Elaine Brosnan; Dimitri Y Chirgadze; Peter J Parker; Tom L Blundell; Helen R Mott
Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1).
The Journal of biological chemistry 2003;278(50):50578-87.
2003: Helen R Mott; Daniel Nietlispach; Louise J Hopkins; Gladys Mirey; Jacques Camonis; Darerca Owen
Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site.
The Journal of biological chemistry 2003;278(19):17053-9.
2002: Peter R Nielsen; Daniel Nietlispach; Helen R Mott; Juliana Callaghan; Andrew J Bannister; Tony Kouzarides; Alexey G Murzin; Natalia V Murzina; Ernest D Laue
Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9.
Nature 2002;416(6876):103-7.
2000: A Morreale; M Venkatesan; Helen R Mott; Darerca Owen; Daniel Nietlispach; Peter N Lowe; Ernest D Laue
Structure of Cdc42 bound to the GTPase binding domain of PAK.
Nature structural biology 2000;7(5):384-8.
2000: Darerca Owen; Helen R Mott; Ernest D Laue; Peter N Lowe
Residues in Cdc42 that specify binding to individual CRIB effector proteins.
Biochemistry 2000;39(6):1243-50.
1999: Helen R Mott; Darerca Owen; Daniel Nietlispach; Peter N Lowe; E Manser; L Lim; Ernest D Laue
Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK.
Nature 1999;399(6734):384-8.