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Jeremy Mottram

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Cutaneous Leishmaniasis

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TOP 3
Maurício F M Machado; Marcelo F Marcondes; Karen McLuskey; Catherine X Moss; Jeremy C Mottram; Luiz Juliano; Maria A Juliano; Vitor Oliveira
Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2.
Caroline Sommerville; Roderick A M Williams; James Alexander; Jeremy C Mottram; Julia M Richardson; Craig William Roberts; Fiona L Henriquez
Biochemical and Immunological Characterization of Toxoplasma gondii Macrophage Migration Inhibitory Factor.
Roderick A M Williams; Jeremy C Mottram; Graham H Coombs
Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of Leishmania major.

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All Publications

2013: Maurício F M Machado; Marcelo F Marcondes; Karen McLuskey; Catherine X Moss; Jeremy C Mottram; Luiz Juliano; Maria A Juliano; Vitor Oliveira
Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2.
The FEBS journal 2013;280(11):2608-21.
2013: Caroline Sommerville; Roderick A M Williams; James Alexander; Jeremy C Mottram; Julia M Richardson; Craig William Roberts; Fiona L Henriquez
Biochemical and Immunological Characterization of Toxoplasma gondii Macrophage Migration Inhibitory Factor.
The Journal of biological chemistry 2013;288(18):12733-41.
2013: Roderick A M Williams; Jeremy C Mottram; Graham H Coombs
Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of Leishmania major.
The Journal of biological chemistry 2013;288(5):3678-90.
2013: William R Proto; Graham H Coombs; Jeremy C Mottram
Cell death in parasitic protozoa: regulated or incidental?
Nature reviews. Microbiology 2013;11(1):58-66.
2012: N O M Ali; Karen M Grant; M E Ibrahim; Jeremy C Mottram
Leishmania mexicana: expression; characterization and activity assessment of E. coli-expressed recombinant CRK3.
European review for medical and pharmacological sciences 2012;16(10):1338-45.
2012: Lesley S Morrison; Laurence Tetley; Petr Volf; Gareth D Westrop; Graham H Coombs; Anna Dostalova; Sylvain C P Eschenlauer; Marilia S Faria; Amy Goundry; Ana Paula C A Lima; Jeremy C Mottram
Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation.
Cellular microbiology 2012;14(8):1271-86.
2012: Karen McLuskey; Catherine X Moss; Graham H Coombs; Neil W Isaacs; William R Proto; Jana Rudolf; Jeremy C Mottram
Crystal structure of a Trypanosoma brucei metacaspase.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(19):7469-74.
2012: E Castanys-Muñoz; Graham H Coombs; E Brown; Jeremy C Mottram
Leishmania mexicana metacaspase is a negative regulator of amastigote proliferation in mammalian cells.
Cell death & disease 2012;3():e385.
2012: Roderick A M Williams; Benjamin Cull; Jeremy C Mottram; Terry K Smith; Graham H Coombs
ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major.
PLoS pathogens 2012;8(5):e1002695.
2012: Corinna Benz; Caroline Clucas; Jeremy C Mottram; Tansy C Hammarton
Cytokinesis in bloodstream stage Trypanosoma brucei requires a family of katanins and spastin.
PloS one 2012;7(1):e30367.
2011: William R Proto; Laurence Tetley; Alana Black; Esther Castanys-Munoz; Graham H Coombs; Luiz Juliano; Catherine X Moss; Jeremy C Mottram
Trypanosoma brucei metacaspase 4 is a pseudopeptidase and a virulence factor.
The Journal of biological chemistry 2011;286(46):39914-25.
2011: Audrey Ambit; Graham H Coombs; Benjamin Cull; Kerry L Woods; Jeremy C Mottram
Morphological events during the cell cycle of Leishmania major.
Eukaryotic cell 2011;10(11):1429-38.
2011: Roderick G Walker; Graeme Thomson; Kirk Malone; Matthew W Nowicki; Elaine Brown; David G Blake; Nicholas J Turner; Malcolm D Walkinshaw; Karen M Grant; Jeremy C Mottram
High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.
PLoS neglected tropical diseases 2011;5(4):e1033.
2011: Marilia S Faria; Flavia C G Reis; Ricardo Azevedo-Pereira; Lesley S Morrison; Jeremy C Mottram; Ana Paula C A Lima
Leishmania inhibitor of serine peptidase 2 prevents TLR4 activation by neutrophil elastase promoting parasite survival in murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(1):411-22.
2011: Jane C Munday; Karen McLuskey; Elaine Brown; Graham H Coombs; Jeremy C Mottram
Oligopeptidase B deficient mutants of Leishmania major.
Molecular and biochemical parasitology 2011;175(1):49-57.
2010: Karen McLuskey; Neil G Paterson; Nicholas D Bland; Neil W Isaacs; Jeremy C Mottram
Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor.
The Journal of biological chemistry 2010;285(50):39249-59.
2010: Owain Millington; Elmarie Myburgh; Jeremy C Mottram; James Alexander
Imaging of the host/parasite interplay in cutaneous leishmaniasis.
Experimental parasitology 2010;126(3):310-7.
2010: Koen Steert; Maya Berg; Jeremy C Mottram; Gareth D Westrop; Graham H Coombs; Paul Cos; Louis Maes; Jurgen Joossens; Pieter Van der Veken; Achiel Haemers; Koen Augustyns
α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB.
ChemMedChem 2010;5(10):1734-48.
2010: Nahla O M Ali; Karen M Grant; Muntaser E Ibrahim; Jeremy C Mottram
Molecular cloning, characterization and overexpression of a novel cyclin from Leishmania mexicana.
Pakistan journal of biological sciences: PJBS 2010;13(16):775-84.
2010: Felipe C Gomes; Nahla Osman M Ali; Elaine Brown; Roderick G Walker; Karen M Grant; Jeremy C Mottram
Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178.
Molecular and biochemical parasitology 2010;171(2):89-96.
2010: Maya Berg; Pieter Van der Veken; Jurgen Joossens; Venkatraj Muthusamy; Matthias Breugelmans; Catherine X Moss; Jana Rudolf; Paul Cos; Graham H Coombs; Louis Maes; Achiel Haemers; Jeremy C Mottram; Koen Augustyns
Design and evaluation of Trypanosoma brucei metacaspase inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(6):2001-6.
2010: A K El-Fadili; H Zangger; Chantal Desponds; I J Gonzalez; H Zalila; Cédric Schaff; A Ives; S Masina; Jeremy C Mottram; Nicolas Fasel
Cathepsin B-like and cell death in the unicellular human pathogen Leishmania.
Cell death & disease 2010;1():e71.
2009: Karen Bryson; Sébastien Besteiro; H Adrienne McGachy; Graham H Coombs; Jeremy C Mottram; James Alexander
Overexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 response.
Infection and immunity 2009;77(7):2971-8.
2009: Séverine Monnerat; Caroline Clucas; Elaine Brown; Jeremy C Mottram; Tansy C Hammarton
Searching for novel cell cycle regulators in Trypanosoma brucei with an RNA interference screen.
BMC research notes 2009;2():46.
2009: Sylvain C P Eschenlauer; Marilia S Faria; Lesley S Morrison; Nicolas Bland; Flavia L Ribeiro-Gomes; George A DosReis; Graham H Coombs; Ana Paula C A Lima; Jeremy C Mottram
Influence of parasite encoded inhibitors of serine peptidases in early infection of macrophages with Leishmania major.
Cellular microbiology 2009;11(1):106-20.
2008: Sébastien Besteiro; Daniela Tonn; Laurence Tetley; Graham H Coombs; Jeremy C Mottram
The AP3 adaptor is involved in the transport of membrane proteins to acidocalcisomes of Leishmania.
Journal of cell science 2008;121(Pt 5):561-70.
2008: Flavia C G dos Reis; Brian O Smith; Camila Chaves Santos; Tatiana F R Costa; Julio Scharfstein; Graham H Coombs; Jeremy C Mottram; Ana Paula C A Lima
The role of conserved residues of chagasin in the inhibition of cysteine peptidases.
FEBS letters 2008;582(4):485-90.
2008: Audrey Ambit; Nicolas Fasel; Graham H Coombs; Jeremy C Mottram
An essential role for the Leishmania major metacaspase in cell cycle progression.
Cell death and differentiation 2008;15(1):113-22.
2007: Catherine X Moss; Gareth D Westrop; Luiz Juliano; Graham H Coombs; Jeremy C Mottram
Metacaspase 2 of Trypanosoma brucei is a calcium-dependent cysteine peptidase active without processing.
FEBS letters 2007;581(29):5635-9.
2007: Tansy C Hammarton; Séverine Monnerat; Jeremy C Mottram
Cytokinesis in trypanosomatids.
Current opinion in microbiology 2007;10(6):520-7.
2007: Koen Steert; Ibrahim El-Sayed; Pieter Van der Veken; Alisa Krishtal; Christian Van Alsenoy; Gareth D Westrop; Jeremy C Mottram; Graham H Coombs; Koen Augustyns; Achiel Haemers
Dipeptidyl alpha-fluorovinyl Michael acceptors: synthesis and activity against cysteine proteases.
Bioorganic & medicinal chemistry letters 2007;17(23):6563-6.
2007: Tansy C Hammarton; Susanne Kramer; Laurence Tetley; Michael Boshart; Jeremy C Mottram
Trypanosoma brucei Polo-like kinase is essential for basal body duplication, kDNA segregation and cytokinesis.
Molecular microbiology 2007;65(5):1229-48.
2007: Sébastien Besteiro; Roderick A M Williams; Graham H Coombs; Jeremy C Mottram
Protein turnover and differentiation in Leishmania.
International journal for parasitology 2007;37(10):1063-75.
2007: Iveth J González; Chantal Desponds; Cédric Schaff; Jeremy C Mottram; Nicolas Fasel
Leishmania major metacaspase can replace yeast metacaspase in programmed cell death and has arginine-specific cysteine peptidase activity.
International journal for parasitology 2007;37(2):161-72.
2006: Marie Schaeffer; Antonio de Miranda; Jeremy C Mottram; Graham H Coombs
Differentiation of Leishmania major is impaired by over-expression of pyroglutamyl peptidase I.
Molecular and biochemical parasitology 2006;150(2):318-29.
2006: Gareth D Westrop; Gordon Goodall; Jeremy C Mottram; Graham H Coombs
Cysteine biosynthesis in Trichomonas vaginalis involves cysteine synthase utilizing O-phosphoserine.
The Journal of biological chemistry 2006;281(35):25062-75.
2006: Roderick A M Williams; Laurence Tetley; Jeremy C Mottram; Graham H Coombs
Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana.
Molecular microbiology 2006;61(3):655-74.
2006: Sylvain C P Eschenlauer; Graham H Coombs; Jeremy C Mottram
PFPI-like genes are expressed in Leishmania major but are pseudogenes in other Leishmania species.
FEMS microbiology letters 2006;260(1):47-54.
2006: Sébastien Besteiro; Roderick A M Williams; Lesley S Morrison; Graham H Coombs; Jeremy C Mottram
Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major.
The Journal of biological chemistry 2006;281(16):11384-96.
2006: Jacqueline Poot; K Spreeuwenberg; Sanya J Sanderson; V E C J Schijns; Jeremy C Mottram; Graham H Coombs; Arno N Vermeulen
Vaccination with a preparation based on recombinant cysteine peptidases and canine IL-12 does not protect dogs from infection with Leishmania infantum.
Vaccine 2006;24(14):2460-8.
2006: Matthew J Helms; Audrey Ambit; Paul Appleton; Laurence Tetley; Graham H Coombs; Jeremy C Mottram
Bloodstream form Trypanosoma brucei depend upon multiple metacaspases associated with RAB11-positive endosomes.
Journal of cell science 2006;119(Pt 6):1105-17.
2006: Brian O Smith; Nichola C Picken; Gareth D Westrop; Krystyna Bromek; Jeremy C Mottram; Graham H Coombs
The structure of Leishmania mexicana ICP provides evidence for convergent evolution of cysteine peptidase inhibitors.
The Journal of biological chemistry 2006;281(9):5821-8.
2006: Hubert Denise; Jacqueline Poot; Maribel Jiménez; Audrey Ambit; Daland C Herrmann; Arno N Vermeulen; Graham H Coombs; Jeremy C Mottram
Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5.
BMC molecular biology 2006;7():42.
2006: Sébastien Besteiro; Graham H Coombs; Jeremy C Mottram
The SNARE protein family of Leishmania major.
BMC genomics 2006;7():250.
2006: Brian O Smith; Gareth D Westrop; Jeremy C Mottram; Graham H Coombs
Chemical shift assignments of Leishmania mexicana ICP, a novel cysteine peptidase inhibitor.
Journal of biomolecular NMR 2006;36 Suppl 1():7.
2005: Christina Naula; Marilyn Parsons; Jeremy C Mottram
Protein kinases as drug targets in trypanosomes and Leishmania.
Biochimica et biophysica acta 2005;1754(1-2):151-9.
2005: Wagner A S Judice; Jeremy C Mottram; Graham H Coombs; Maria A Juliano; Luiz Juliano
Specific negative charges in cysteine protease isoforms of Leishmaniamexicana are highly influential on the substrate binding and hydrolysis.
Molecular and biochemical parasitology 2005;144(1):36-43.
2005: Tansy C Hammarton; Simon G Lillico; Susan C Welburn; Jeremy C Mottram
Trypanosoma brucei MOB1 is required for accurate and efficient cytokinesis but not for exit from mitosis.
Molecular microbiology 2005;56(1):104-16.
2004: Sébastien Besteiro; Graham H Coombs; Jeremy C Mottram
A potential role for ICP, a Leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite.
Molecular microbiology 2004;54(5):1224-36.
2004: Maria A Juliano; Darren R Brooks; Paul M Selzer; Hector L Pandolfo; Wagner A S Judice; Luiz Juliano; Morten Meldal; Sanya J Sanderson; Jeremy C Mottram; Graham H Coombs
Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes.
European journal of biochemistry / FEBS 2004;271(18):3704-14.
2004: Jeremy C Mottram; Graham H Coombs; James Alexander
Cysteine peptidases as virulence factors of Leishmania.
Current opinion in microbiology 2004;7(4):375-81.
2004: Karen M Grant; Morag H Dunion; Vanessa Yardley; Alexios-Leandros Skaltsounis; Doris Marko; Gerhard Eisenbrand; Simon L Croft; Laurent Meijer; Jeremy C Mottram
Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.
Antimicrobial agents and chemotherapy 2004;48(8):3033-42.
2004: Tansy C Hammarton; Markus Engstler; Jeremy C Mottram
The Trypanosoma brucei cyclin, CYC2, is required for cell cycle progression through G1 phase and for maintenance of procyclic form cell morphology.
The Journal of biological chemistry 2004;279(23):24757-64.
2004: Hubert Denise; Graham H Coombs; Jeremy C Mottram
Generation of Leishmania mutants lacking antibiotic resistance genes using a versatile hit-and-run targeting strategy.
FEMS microbiology letters 2004;235(1):89-94.
2004: Christian W Tornøe; Sanya J Sanderson; Jeremy C Mottram; Graham H Coombs; Morten Meldal
Combinatorial library of peptidotriazoles: identification of [1,2,3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine protease.
Journal of combinatorial chemistry 2004;6(3):312-24.
2004: Graham H Coombs; Gareth D Westrop; Pavel Suchan; Gabriela Puzova; Robert Hirt; T Martin Embley; Jeremy C Mottram; Sylke Müller
The amitochondriate eukaryote Trichomonas vaginalis contains a divergent thioredoxin-linked peroxiredoxin antioxidant system.
The Journal of biological chemistry 2004;279(7):5249-56.
2003: Laurence U Buxbaum; Hubert Denise; Graham H Coombs; James Alexander; Jeremy C Mottram; Phillip Scott
Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(7):3711-7.
2003: Tansy C Hammarton; Jade Clark; Fiona Douglas; Michael Boshart; Jeremy C Mottram
Stage-specific differences in cell cycle control in Trypanosoma brucei revealed by RNA interference of a mitotic cyclin.
The Journal of biological chemistry 2003;278(25):22877-86.
2003: Hubert Denise; Kathryn McNeil; Darren R Brooks; James Alexander; Graham H Coombs; Jeremy C Mottram
Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo.
Infection and immunity 2003;71(6):3190-5.
2003: Sanya J Sanderson; Gareth D Westrop; J Scharfstein; Jeremy C Mottram; Graham H Coombs
Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens.
FEBS letters 2003;542(1-3):12-6.
2003: Jeremy C Mottram; Matthew J Helms; Graham H Coombs; Mohammed Sajid
Clan CD cysteine peptidases of parasitic protozoa.
Trends in parasitology 2003;19(4):182-7.
2003: Simon G Lillico; Mark Field; Pat Blundell; Graham H Coombs; Jeremy C Mottram
Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8.
Molecular biology of the cell 2003;14(3):1182-94.
2003: Kevin G J Pollock; Katherine S McNeil; Jeremy C Mottram; Russell E Lyons; James M Brewer; Phillip Scott; Graham H Coombs; James Alexander
The Leishmania mexicana cysteine protease, CPB2.8, induces potent Th2 responses.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1746-53.
2003: Roderick A M Williams; Sharon M Kelly; Jeremy C Mottram; Graham H Coombs
3-Mercaptopyruvate sulfurtransferase of Leishmania contains an unusual C-terminal extension and is involved in thioredoxin and antioxidant metabolism.
The Journal of biological chemistry 2003;278(3):1480-6.
2003: Tansy C Hammarton; Jeremy C Mottram; Christian Doerig
The cell cycle of parasitic protozoa: potential for chemotherapeutic exploitation.
Progress in cell cycle research 2003;5():91-101.
2002: Sally Corradin; Adriana Ransijn; Giampietro Corradin; Jacques Bouvier; Maria Belen Delgado; Jimena Fernandez-Carneado; Jeremy C Mottram; Guy Vergères; Jacques Mauël
Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein.
The Biochemical journal 2002;367(Pt 3):761-9.
2002: H Zangger; Jeremy C Mottram; Nicolas Fasel
Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis?
Cell death and differentiation 2002;9(10):1126-39.
2002: Miriam Ellis; Deepak K Sharma; James D Hilley; Graham H Coombs; Jeremy C Mottram
Processing and trafficking of Leishmania mexicana GP63. Analysis using GP18 mutants deficient in glycosylphosphatidylinositol protein anchoring.
The Journal of biological chemistry 2002;277(31):27968-74.
2002: Marie Knockaert; Karen Wieking; Sophie Schmitt; Maryse Leost; Karen M Grant; Jeremy C Mottram; Conrad Kunick; Laurent Meijer
Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor.
The Journal of biological chemistry 2002;277(28):25493-501.
2002: Simon G Lillico; Jeremy C Mottram; Noel Murphy; Susan C Welburn
Characterisation of the QM gene of Trypanosoma brucei.
FEMS microbiology letters 2002;211(2):123-8.
2002: Phaedria M St Hilaire; Lira C Alves; Fatima Herrera; Manat Renil; Sanya J Sanderson; Jeremy C Mottram; Graham H Coombs; Maria A Juliano; Luiz Juliano; Jorge Arevalo; Morten Meldal
Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B.
Journal of medicinal chemistry 2002;45(10):1971-82.
2001: Darren R Brooks; Hubert Denise; Gareth D Westrop; Graham H Coombs; Jeremy C Mottram
The stage-regulated expression of Leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element.
The Journal of biological chemistry 2001;276(50):47061-9.
2001: Graham H Coombs; D E Goldberg; M Klemba; C Berry; J Kay; Jeremy C Mottram
Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets.
Trends in parasitology 2001;17(11):532-7.
2001: Lira C Alves; Robson L Melo; Maria Helena S Cezari; Sanya J Sanderson; Jeremy C Mottram; Graham H Coombs; Luiz Juliano; Maria A Juliano
Analysis of the S(2) subsite specificities of the recombinant cysteine proteinases CPB of Leishmania mexicana, and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural basic amino acids.
Molecular and biochemical parasitology 2001;117(2):137-43.
2001: A Graven; Phaedria M St Hilaire; Sanya J Sanderson; Jeremy C Mottram; Graham H Coombs; Morten Meldal
Combinatorial library of peptide isosters based on Diels-Alder reactions: identification of novel inhibitors against a recombinant cysteine protease from Leishmania mexicana.
Journal of combinatorial chemistry 2001;3(5):441-52.
2001: Lira C Alves; Wagner A S Judice; Phaedria M St Hilaire; Morten Meldal; Sanya J Sanderson; Jeremy C Mottram; Graham H Coombs; Luiz Juliano; Maria A Juliano
Substrate specificity of recombinant cysteine proteinase, CPB, of Leishmania mexicana.
Molecular and biochemical parasitology 2001;116(1):1-9.
2001: Graham H Coombs; Jeremy C Mottram
Trifluoromethionine, a prodrug designed against methionine gamma-lyase-containing pathogens, has efficacy in vitro and in vivo against Trichomonas vaginalis.
Antimicrobial agents and chemotherapy 2001;45(6):1743-5.
2001: Lira C Alves; Phaedria M St Hilaire; Morten Meldal; Sanya J Sanderson; Jeremy C Mottram; Graham H Coombs; Luiz Juliano; Maria A Juliano
Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana.
Molecular and biochemical parasitology 2001;114(1):81-8.
2001: P Hassan; David Fergusson; Karen M Grant; Jeremy C Mottram
The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana.
Molecular and biochemical parasitology 2001;113(2):189-98.
2001: Lira C Alves; Robson L Melo; Sanya J Sanderson; Jeremy C Mottram; Graham H Coombs; Giuseppe Caliendo; Vincenzo Santagada; Luiz Juliano; Maria A Juliano
S1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids.
European journal of biochemistry / FEBS 2001;268(5):1206-12.
2000: Jaap J van Hellemond; Jeremy C Mottram
The CYC3 gene of trypanosoma brucei encodes a cyclin with a short half-life.
Molecular and biochemical parasitology 2000;111(2):275-82.
2000: Tansy C Hammarton; J R Ford; Jeremy C Mottram
Trypanosoma brucei CYC1 does not have characteristics of a mitotic cyclin.
Molecular and biochemical parasitology 2000;111(1):229-34.
2000: Darren R Brooks; Laurence Tetley; Graham H Coombs; Jeremy C Mottram
Processing and trafficking of cysteine proteases in Leishmania mexicana.
Journal of cell science 2000;113 ( Pt 22)():4035-41.
2000: Deepak K Sharma; James D Hilley; James D Bangs; Graham H Coombs; Jeremy C Mottram; Anant K Menon
Soluble GPI8 restores glycosylphosphatidylinositol anchoring in a trypanosome cell-free system depleted of lumenal endoplasmic reticulum proteins.
The Biochemical journal 2000;351 Pt 3():717-22.
2000: MJ Frame; Jeremy C Mottram; Graham H Coombs
Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host-parasite interaction.
Parasitology 2000;121 ( Pt 4)():367-77.
2000: Phaedria M St Hilaire; Lira C Alves; Sanya J Sanderson; Jeremy C Mottram; Maria A Juliano; Luiz Juliano; Graham H Coombs; Morten Meldal
The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: application of a combinatorial peptide library approach.
Chembiochem : a European journal of chemical biology 2000;1(2):115-22.
2000: Marie Knockaert; Nathanael S Gray; E Damiens; Y T Chang; P Grellier; K Grant; David Fergusson; Jeremy C Mottram; M Soete; Jean-François Dubremetz; Karine G Le Roch; Christian Doerig; P Schultz; Laurent Meijer
Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.
Chemistry & biology 2000;7(6):411-22.
2000: Darren R Brooks; Richard McCulloch; Graham H Coombs; Jeremy C Mottram
Stable transformation of trypanosomatids through targeted chromosomal integration of the selectable marker gene encoding blasticidin S deaminase.
FEMS microbiology letters 2000;186(2):287-91.
2000: Sanya J Sanderson; Kevin G J Pollock; James D Hilley; Morten Meldal; P S Hilaire; Maria A Juliano; Luiz Juliano; Jeremy C Mottram; Graham H Coombs
Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana.
The Biochemical journal 2000;347(Pt 2):383-8.
2000: James D Hilley; JL Zawadzki; Malcolm J McConville; Graham H Coombs; Jeremy C Mottram
Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins.
Molecular biology of the cell 2000;11(4):1183-95.
2000: Jaap J van Hellemond; P Neuville; R T Schwarz; Keith Matthews; Jeremy C Mottram
Isolation of Trypanosoma brucei CYC2 and CYC3 cyclin genes by rescue of a yeast G(1) cyclin mutant. Functional characterization of CYC2.
The Journal of biological chemistry 2000;275(12):8315-23.
1999: Michael P Barrett; Jeremy C Mottram; Graham H Coombs
Recent advances in identifying and validating drug targets in trypanosomes and leishmanias.
Trends in microbiology 1999;7(2):82-8.
1998: Jeremy C Mottram; D R Brooks; Graham H Coombs
Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions.
Current opinion in microbiology 1998;1(4):455-60.
1998: Karen M Grant; P Hassan; J S Anderson; Jeremy C Mottram
The crk3 gene of Leishmania mexicana encodes a stage-regulated cdc2-related histone H1 kinase that associates with p12.
The Journal of biological chemistry 1998;273(17):10153-9.
1998: A E McKie; T Edlind; J Walker; Jeremy C Mottram; Graham H Coombs
The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymes.
The Journal of biological chemistry 1998;273(10):5549-56.
1997: G Bart; MJ Frame; R Carter; Graham H Coombs; Jeremy C Mottram
Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana.
Molecular and biochemical parasitology 1997;88(1-2):53-61.
1997: Jeremy C Mottram; MJ Frame; Darren R Brooks; Laurence Tetley; J E Hutchison; A E Souza; Graham H Coombs
The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences.
The Journal of biological chemistry 1997;272(22):14285-93.
1997: Graham H Coombs; Jeremy C Mottram
Parasite proteinases and amino acid metabolism: possibilities for chemotherapeutic exploitation.
Parasitology 1997;114 Suppl():S61-80.
1996: Jeremy C Mottram; B P McCready; K G Brown; K M Grant
Gene disruptions indicate an essential function for the LmmCRK1 cdc2-related kinase of Leishmania mexicana.
Molecular microbiology 1996;22(3):573-83.
1996: Jeremy C Mottram; K M Grant
Leishmania mexicana p12cks1, a homologue of fission yeast p13suc1, associates with a stage-regulated histone H1 kinase.
The Biochemical journal 1996;316 ( Pt 3)():833-9.
1996: Jeremy C Mottram; A E Souza; J E Hutchison; R Carter; M J Frame; Graham H Coombs
Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):6008-13.
1995: Jeremy C Mottram; G Smith
A family of trypanosome cdc2-related protein kinases.
Gene 1995;162(1):147-52.
1995: G Bart; Graham H Coombs; Jeremy C Mottram
Isolation of lmcpc, a gene encoding a Leishmania mexicana cathepsin-B-like cysteine proteinase.
Molecular and biochemical parasitology 1995;73(1-2):271-4.
1994: Jeremy C Mottram
cdc2-related protein kinases and cell cycle control in trypanosomatids.
Parasitology today (Personal ed.) 1994;10(7):253-7.
1994: A E Souza; P A Bates; Graham H Coombs; Jeremy C Mottram
Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana.
Molecular and biochemical parasitology 1994;63(2):213-20.
1993: Jeremy C Mottram; Jane H Kinnaird; Brian R Shiels; Andy Tait; J David Barry
A novel CDC2-related protein kinase from Leishmania mexicana, LmmCRK1, is post-translationally regulated during the life cycle.
The Journal of biological chemistry 1993;268(28):21044-52.
1992: A E Souza; S Waugh; Graham H Coombs; Jeremy C Mottram
Characterization of a multi-copy gene for a major stage-specific cysteine proteinase of Leishmania mexicana.
FEBS letters 1992;311(2):124-7.
1992: Jeremy C Mottram; C D Robertson; Graham H Coombs; J David Barry
A developmentally regulated cysteine proteinase gene of Leishmania mexicana.
Molecular microbiology 1992;6(14):1925-32.
1991: Jeremy C Mottram; Steve Bell; R G Nelson; J David Barry
tRNAs of Trypanosoma brucei. Unusual gene organization and mitochondrial importation.
The Journal of biological chemistry 1991;266(27):18313-7.
1991: Jeremy C Mottram; Y Shafi; J David Barry
Sequence of a tRNA gene cluster in Trypanosoma brucei.
Nucleic acids research 1991;19(14):3995.
1990: M J North; Jeremy C Mottram; Graham H Coombs
Cysteine proteinases of parasitic protozoa.
Parasitology today (Personal ed.) 1990;6(8):270-5.
1989: Jeremy C Mottram; M J North; J David Barry; Graham H Coombs
A cysteine proteinase cDNA from Trypanosoma brucei predicts an enzyme with an unusual C-terminal extension.
FEBS letters 1989;258(2):211-5.