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Howard Mount

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Beverly M Francis; Enid Hajderi; Joanne McLaurin; Bernadeta Michalski; Mary E Brown; Margaret Fahnestock; Jimao Yang; Howard T J Mount
Reduced tissue levels of noradrenaline are associated with behavioral phenotypes of the TgCRND8 mouse model of Alzheimer's disease.
Beverly M Francis; John Kim; Joanne McLaurin; Bernadeta Michalski; Meredith E Barakat; Margaret Fahnestock; Stephan Fraenkl; Shiyong Peng; Yeni H Yücel; Howard T J Mount
Object recognition memory and BDNF expression are reduced in young TgCRND8 mice.
Christiane B Knobbe; Tak W Mak; Howard T J Mount; Timothy J Revett; Yu Bai; Christopher Böhm; Vinca Chow; Sepehr Ehsani; Amy Hye Won Jeon; Thomas Kislinger; Peter St George-Hyslop; Gerold Schmitt-Ulms
Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90.

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All Publications

2012: Beverly M Francis; Enid Hajderi; Joanne McLaurin; Bernadeta Michalski; Mary E Brown; Margaret Fahnestock; Jimao Yang; Howard T J Mount
Reduced tissue levels of noradrenaline are associated with behavioral phenotypes of the TgCRND8 mouse model of Alzheimer's disease.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(8):1934-44.
2012: Beverly M Francis; John Kim; Joanne McLaurin; Bernadeta Michalski; Meredith E Barakat; Margaret Fahnestock; Stephan Fraenkl; Shiyong Peng; Yeni H Yücel; Howard T J Mount
Object recognition memory and BDNF expression are reduced in young TgCRND8 mice.
Neurobiology of aging 2012;33(3):555-63.
2011: Christiane B Knobbe; Tak W Mak; Howard T J Mount; Timothy J Revett; Yu Bai; Christopher Böhm; Vinca Chow; Sepehr Ehsani; Amy Hye Won Jeon; Thomas Kislinger; Peter St George-Hyslop; Gerold Schmitt-Ulms
Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90.
Journal of proteome research 2011;10(10):4388-404.
2011: Keran Ma; Howard T J Mount; JoAnne McLaurin
Region-specific distribution of β-amyloid peptide and cytokine expression in TgCRND8 mice.
Neuroscience letters 2011;492(1):5-10.
2011: Loren J Martin; Agnieszka A Zurek; Robert P Bonin; Gabriel H T Oh; John H Kim; Howard T J Mount; Beverley A Orser
The sedative but not the memory-blocking properties of ethanol are modulated by α5-subunit-containing γ-aminobutyric acid type A receptors.
Behavioural brain research 2011;217(2):379-85.
2010: Nobuo Sanjo; Taiichi Katayama; Hiroshi Hasegawa; Haifeng Jin; Monika Duthie; Howard T J Mount; Hidehiro Mizusawa; Peter St George-Hyslop; Paul E Fraser
Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related gamma-secretase.
Neuroscience letters 2010;483(1):53-6.
2009: Alexandra Auffret; Vanessa Gautheron; Mariaelena Repici; Rudolf Kraftsik; Howard T J Mount; Jean Mariani; Catherine Rovira
Age-dependent impairment of spine morphology and synaptic plasticity in hippocampal CA1 neurons of a presenilin 1 transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(32):10144-52.
2009: Shiyong Peng; Diego J Garzon; Monica Marchese; William L Klein; Stephen D. Ginsberg; Beverly M Francis; Howard T J Mount; Elliott J Mufson; Ahmad Salehi; Margaret Fahnestock
Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(29):9321-9.
2009: Ameer Y Taha; Chuck T Chen; Zhen Liu; John H Kim; Howard T J Mount; Richard P Bazinet
Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor.
Neurochemical research 2009;34(2):311-5.
2009: A Amritraj; Cheryl Hawkes; A L Phinney; Howard T J Mount; C D Scott; David Westaway; Satyabrata Kar
Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP + PS1 transgenic mouse brains.
Neurobiology of aging 2009;30(1):54-70.
2008: Chuck T Chen; David W L Ma; John H Kim; Howard T J Mount; Richard P Bazinet
The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations.
Journal of lipid research 2008;49(1):147-52.
2007: Joel C Watts; Bettina Drisaldi; Vivian Ng; Jing Yang; Bob Strome; Patrick Horne; Man-Sun Sy; Larry Yoong; Rebecca Young; Peter Mastrangelo; Catherine Bergeron; Paul E Fraser; George A Carlson; Howard T J Mount; Gerold Schmitt-Ulms; David Westaway
The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.
The EMBO journal 2007;26(17):4038-50.
2006: JoAnne McLaurin; Meredith E Kierstead; Mary E Brown; Cheryl A Hawkes; Mark H L Lambermon; Amie L Phinney; Audrey A Darabie; Julian E Cousins; John French; Melissa F Lan; Fusheng Chen; Sydney S N Wong; Howard T J Mount; Paul E Fraser; David Westaway; Peter St George-Hyslop
Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.
Nature medicine 2006;12(7):801-8.
2006: Victor Y Cheng; Loren martin; Erin M Elliott; John H Kim; Howard T J Mount; Franco A Taverna; John C Roder; John F MacDonald; Amit Bhambri; Neil Collinson; Keith A Wafford; Beverley A Orser
Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(14):3713-20.
2004: Bettina Drisaldi; Janaky Coomaraswamy; Peter Mastrangelo; Bob Strome; Jing Yang; Joel C Watts; M Azhar Chishti; Melissa Marvi; Otto Windl; Rosemary Ahrens; François Major; Man-Sun Sy; Hans A Kretzschmar; Paul E Fraser; Howard T J Mount; David Westaway
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.
The Journal of biological chemistry 2004;279(53):55443-54.
2004: Satyabrata Kar; Stephen P M Slowikowski; David Westaway; Howard T J Mount
Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease.
Journal of psychiatry & neuroscience : JPN 2004;29(6):427-41.
2004: Howard T J Mount; Jean-Claude Martel; Paul Fluit; Yingji Wu; Eleanor Gallo-Hendrikx; Cristina Cosi; Marc Marien
Progressive sensorimotor impairment is not associated with reduced dopamine and high energy phosphate donors in a model of ataxia-telangiectasia.
Journal of neurochemistry 2004;88(6):1449-54.
2003: Fusheng Chen; Anurag Tandon; Nobuo Sanjo; Yong-Jun Gu; Hiroshi Hasegawa; Shigeki Arawaka; Frank J S Lee; Xueying Ruan; Peter Mastrangelo; Serap Erdebil; Linda Wang; David Westaway; Howard T J Mount; Bruce A Yankner; Paul E Fraser; Peter St George-Hyslop
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
The Journal of biological chemistry 2003;278(22):19974-9.
2003: Yongjun Gu; Fusheng Chen; Nobuo Sanjo; Toshitaka Kawarai; Hiroshi Hasegawa; Monika Duthie; Wenping Li; Xueying Ruan; Anchla Luthra; Howard T J Mount; Anurag Tandon; Paul E Fraser; Peter St George-Hyslop
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes.
The Journal of biological chemistry 2003;278(9):7374-80.
2002: JoAnne McLaurin; Roxana Cecal; M E Kierstead; X Tian; Amie L Phinney; Marilena Manea; J E French; Mark H L Lambermon; Audrey A Darabie; Mary E Brown; Christopher Janus; M Azhar Chishti; Patrick Horne; David Westaway; Paul E Fraser; Howard T J Mount; M Przybylski; Peter St George-Hyslop
Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.
Nature medicine 2002;8(11):1263-9.
2002: Richard Rozmahel; Howard T J Mount; Fusheng Chen; Van Nguyen; Jean Huang; Serap Erdebil; Jennifer Liauw; Gang G. Yu; Hiroshe Hasegawa; YongJun Gu; You-Qiang Song; Stephen D Schmidt; Ralph A. Nixon; Paul Mathews; Catherine Bergeron; Paul E Fraser; David Westaway; Peter St George-Hyslop
Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14452-7.
2002: Fusheng Chen; YongJun Gu; Hiroshi Hasegawa; Xueying Ruan; Shigeki Arawaka; Paul E Fraser; David Westaway; Howard T J Mount; Peter St George-Hyslop
Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
The Journal of biological chemistry 2002;277(39):36521-6.
2002: Dun-Sheng Yang; Anurag Tandon; Fusheng Chen; Gang G. Yu; Haung Yu; Shigeki Arawaka; Hiroshi Hasegawa; Monika Duthie; Stephen D Schmidt; Triprayer V Ramabhadran; Ralph A. Nixon; Paul Mathews; Sam Gandy; Howard T J Mount; Peter St George-Hyslop; Paul E Fraser
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins.
The Journal of biological chemistry 2002;277(31):28135-42.
2002: E Vaucher; P Fluit; M Azhar Chishti; David Westaway; Howard T J Mount; Satyabrata Kar
Object recognition memory and cholinergic parameters in mice expressing human presenilin 1 transgenes.
Experimental neurology 2002;175(2):398-406.
2001: Paul E Fraser; Gang G. Yu; L Lévesque; M Nishimura; Dun-Sheng Yang; Howard T J Mount; David Westaway; Peter St George-Hyslop
Presenilin function: connections to Alzheimer's disease and signal transduction.
Biochemical Society symposium 2001;(67):89-100.
2000: Christopher Janus; J Pearson; JoAnne McLaurin; Paul Mathews; Y Jiang; Stephen D Schmidt; M Azhar Chishti; Patrick Horne; D Heslin; J French; Howard T J Mount; Ralph A. Nixon; Marc Mercken; Catherine Bergeron; Paul E Fraser; Peter St George-Hyslop; David Westaway
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.
Nature 2000;408(6815):979-82.
2000: Fusheng Chen; Dun-Sheng Yang; Suzana Petanceska; Austin Yang; Anurag Tandon; Gang G. Yu; Richard Rozmahel; Jorge Ghiso; M Nishimura; DM Zhang; Toshitaka Kawarai; Georges Levesque; J Mills; L Levesque; You-Qiang Song; Ekaterina Rogaeva; David Westaway; Howard T J Mount; Sam Gandy; Peter St George-Hyslop; Paul E Fraser
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
The Journal of biological chemistry 2000;275(47):36794-802.
1999: M Nishimura; Gang G. Yu; Georges Levesque; DM Zhang; L Ruel; Fusheng Chen; P Milman; E Holmes; Yan Liang; Toshitaka Kawarai; E Jo; Agnes Supala; Ekaterina Rogaeva; D M Xu; Christopher Janus; L Levesque; Q Bi; Monika Duthie; Richard Rozmahel; K Mattila; Lars Lannfelt; David Westaway; Howard T J Mount; James R Woodgett; Peter St George-Hyslop
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex.
Nature medicine 1999;5(2):164-9.