Ole Mouritsen

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González-Pérez Alfredo; Stibius Karin B; Vissing Thomas; Nielsen Claus H; Mouritsen Ole G
Biomimetic triblock copolymer membrane arrays: a stable template for functional membrane proteins.
Yde Christina W; Clausen Mathias P; Bennetzen Martin V; Lykkesfeldt Anne E; Mouritsen Ole G; Guerra Barbara
The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells.
Pedersen Palle J; Christensen Mikkel S; Ruysschaert Tristan; Linderoth Lars; Andresen Thomas L; Melander Fredrik; Mouritsen Ole G; Madsen Robert; Clausen Mads H
Synthesis and biophysical characterization of chlorambucil anticancer ether lipid prodrugs.

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All Publications

2009: González-Pérez Alfredo; Stibius Karin B; Vissing Thomas; Nielsen Claus H; Mouritsen Ole G
Biomimetic triblock copolymer membrane arrays: a stable template for functional membrane proteins.
Langmuir : the ACS journal of surfaces and colloids 2009;25(18):10447-50.
2009: Yde Christina W; Clausen Mathias P; Bennetzen Martin V; Lykkesfeldt Anne E; Mouritsen Ole G; Guerra Barbara
The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells.
Anti-cancer drugs 2009;20(8):723-35.
2009: Pedersen Palle J; Christensen Mikkel S; Ruysschaert Tristan; Linderoth Lars; Andresen Thomas L; Melander Fredrik; Mouritsen Ole G; Madsen Robert; Clausen Mads H
Synthesis and biophysical characterization of chlorambucil anticancer ether lipid prodrugs.
Journal of medicinal chemistry 2009;52(10):3408-15.
2009: Khandelia Himanshu; Mouritsen Ole G
Lipid gymnastics: evidence of complete acyl chain reversal in oxidized phospholipids from molecular simulations.
Biophysical journal 2009;96(7):2734-43.
2009: Khandelia Himanshu; Jensen Morten Ø; Mouritsen Ole G
To gate or not to gate: using molecular dynamics simulations to morph gated plant aquaporins into constitutively open conformations.
The journal of physical chemistry. B 2009;113(15):5239-44.
2008: Thormann Esben; Simonsen Adam C; Hansen Per L; Mouritsen Ole G
Force trace hysteresis and temperature dependence of bridging nanobubble induced forces between hydrophobic surfaces.
ACS nano 2008;2(9):1817-24.
2008: Thormann Esben; Simonsen Adam C; Hansen Per L; Mouritsen Ole G
Interactions between a polystyrene particle and hydrophilic and hydrophobic surfaces in aqueous solutions.
Langmuir : the ACS journal of surfaces and colloids 2008;24(14):7278-84.
2008: Khandelia Himanshu; Ipsen John H; Mouritsen Ole G
The impact of peptides on lipid membranes.
Biochimica et biophysica acta 2008;1778(7-8):1528-36.
2007: Nielsen Lars K; Bjørnholm Thomas; Mouritsen Ole G
Thermodynamic and real-space structural evidence of a 2D critical point in phospholipid monolayers.
Langmuir : the ACS journal of surfaces and colloids 2007;23(23):11684-92.
2007: Thormann Esben; Simonsen Adam C; Nielsen Lars K; Mouritsen Ole G
Ligand-receptor interactions and membrane structure investigated by AFM and time-resolved fluorescence microscopy.
Journal of molecular recognition : JMR 2007;20(6):554-60.
2007: Thormann Esben; Dreyer Jakob K; Simonsen Adam C; Hansen Per L; Hansen Søren; Holmskov Uffe; Mouritsen Ole G
Dynamic strength of the interaction between lung surfactant protein D (SP-D) and saccharide ligands.
Biochemistry 2007;46(43):12231-7.
2007: Jacobson Ken; Mouritsen Ole G; Anderson Richard G W
Lipid rafts: at a crossroad between cell biology and physics.
Nature cell biology 2007;9(1):7-14.
2006: Thormann Esben; Hansen Per Lyngs; Simonsen Adam Cohen; Mouritsen Ole G
Dynamic force spectroscopy on soft molecular systems: improved analysis of unbinding spectra with varying linker compliance.
Colloids and surfaces. B, Biointerfaces 2006;53(2):149-56.
2006: Alakoskela Juha-Matti; Jutila Arimatti; Simonsen Adam C; Pirneskoski Jussi; Pyhäjoki Sinikka; Turunen Raija; Marttila Sani; Mouritsen Ole G; Goormaghtigh Erik; Kinnunen Paavo K J
Characteristics of fibers formed by cytochrome c and induced by anionic phospholipids.
Biochemistry 2006;45(45):13447-53.
2006: Leidy Chad; Linderoth Lars; Andresen Thomas L; Mouritsen Ole G; Jørgensen Kent; Peters Günther H
Domain-induced activation of human phospholipase A2 type IIA: local versus global lipid composition.
Biophysical journal 2006;90(9):3165-75.
2006: Jensen Morten Ø; Mouritsen Ole G
Single-channel water permeabilities of Escherichia coli aquaporins AqpZ and GlpF.
Biophysical journal 2006;90(7):2270-84.
2006: Jakobsen Ask F; Besold Gerhard; Mouritsen Ole G
Multiple time step update schemes for dissipative particle dynamics.
The Journal of chemical physics 2006;124(9):94104.
2005: Pedersen Tina B; Kaasgaard Thomas; Jensen Morten Ø; Frokjaer Sven; Mouritsen Ole G; Jørgensen Kent
Phase behavior and nanoscale structure of phospholipid membranes incorporated with acylated C14-peptides.
Biophysical journal 2005;89(4):2494-503.
2005: Halperin Avi; Mouritsen Ole G
Role of lipid protrusions in the function of interfacial enzymes.
European biophysics journal : EBJ 2005;34(7):967-71.
2005: Jakobsen Ask F; Mouritsen Ole G; Besold Gerhard
Artifacts in dynamical simulations of coarse-grained model lipid bilayers.
The Journal of chemical physics 2005;122(20):204901.
2005: Keller Danielle; Larsen Niels B; Møller Ian M; Mouritsen Ole G
Decoupled phase transitions and grain-boundary melting in supported phospholipid bilayers.
Physical review letters 2005;94(2):025701.
2004: Mouritsen Ole G; Zuckermann Martin J
What's so special about cholesterol?
Lipids 2004;39(11):1101-13.
2004: Jensen Morten Ø; Mouritsen Ole G
Lipids do influence protein function-the hydrophobic matching hypothesis revisited.
Biochimica et biophysica acta 2004;1666(1-2):205-26.
2004: Hedin Eva M K; Hult Karl; Mouritsen Ole G; Høyrup Pernille
Low microwave-amplitude ESR spectroscopy: measuring spin-relaxation interactions of moderately immobilized spin labels in proteins.
Journal of biochemical and biophysical methods 2004;60(2):117-38.
2004: Leidy Chad; Mouritsen Ole G; Jørgensen Kent; Peters Günther H
Evolution of a rippled membrane during phospholipase A2 hydrolysis studied by time-resolved AFM.
Biophysical journal 2004;87(1):408-18.
2004: Jensen Morten Ø; Mouritsen Ole G; Peters Gunther H
Simulations of a membrane-anchored peptide: structure, dynamics, and influence on bilayer properties.
Biophysical journal 2004;86(6):3556-75.
2004: Jensen Morten Ø; Mouritsen Ole G; Peters Günther H
The hydrophobic effect: molecular dynamics simulations of water confined between extended hydrophobic and hydrophilic surfaces.
The Journal of chemical physics 2004;120(20):9729-44.
2004: Andresen Thomas L; Davidsen Jesper; Begtrup Mikael; Mouritsen Ole G; Jørgensen Kent
Enzymatic release of antitumor ether lipids by specific phospholipase A2 activation of liposome-forming prodrugs.
Journal of medicinal chemistry 2004;47(7):1694-703.
2004: Zuckermann Martin J; Ipsen John H; Miao Ling; Mouritsen Ole G; Nielsen Morten; Polson James; Thewalt Jenifer; Vattulainen Ilpo; Zhu Hong
Modeling lipid-sterol bilayers: applications to structural evolution, lateral diffusion, and rafts.
Methods in enzymology 2004;383():198-229.
2003: Cohen Simonsen A; Bernchou Jensen U; Faergeman N J; Knudsen J; Mouritsen O G
Acyl-coenzyme A organizes laterally in membranes and is recognized specifically by acyl-coenzyme A binding protein.
FEBS letters 2003;552(2-3):253-8.
2003: Kaasgaard Thomas; Mouritsen Ole G; Jørgensen Kent
Freeze/thaw effects on lipid-bilayer vesicles investigated by differential scanning calorimetry.
Biochimica et biophysica acta 2003;1615(1-2):77-83.
2003: Kaasgaard Thomas; Leidy Chad; Crowe John H; Mouritsen Ole G; Jørgensen Kent
Temperature-controlled structure and kinetics of ripple phases in one- and two-component supported lipid bilayers.
Biophysical journal 2003;85(1):350-60.
2003: Davidsen Jesper; Jørgensen Kent; Andresen Thomas L; Mouritsen Ole G
Secreted phospholipase A(2) as a new enzymatic trigger mechanism for localised liposomal drug release and absorption in diseased tissue.
Biochimica et biophysica acta 2003;1609(1):95-101.
2002: Leidy Chad; Kaasgaard Thomas; Crowe John H; Mouritsen Ole G; Jørgensen Kent
Ripples and the formation of anisotropic lipid domains: imaging two-component supported double bilayers by atomic force microscopy.
Biophysical journal 2002;83(5):2625-33.
2002: Jørgensen Kent; Davidsen Jesper; Mouritsen Ole G
Biophysical mechanisms of phospholipase A2 activation and their use in liposome-based drug delivery.
FEBS letters 2002;531(1):23-7.
2002: Davidsen Jesper; Mouritsen Ole G; Jørgensen Kent
Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes.
Biochimica et biophysica acta 2002;1564(1):256-62.
2002: Jensen Morten Ø; Jensen Torben R; Kjaer Kristian; Bjørnholm Thomas; Mouritsen Ole G; Peters Günther H
Orientation and conformation of a lipase at an interface studied by molecular dynamics simulations.
Biophysical journal 2002;83(1):98-111.
2002: Kaasgaard Thomas; Mouritsen Ole G; Jørgensen Kent
Lipid domain formation and ligand-receptor distribution in lipid bilayer membranes investigated by atomic force microscopy.
FEBS letters 2002;515(1-3):29-34.
2002: Miao Ling; Nielsen Morten; Thewalt Jenifer; Ipsen John H; Bloom Myer; Zuckermann Martin J; Mouritsen Ole G
From lanosterol to cholesterol: structural evolution and differential effects on lipid bilayers.
Biophysical journal 2002;82(3):1429-44.
2002: Pedersen Tina B; Frokjaer Sven; Mouritsen Ole G; Jørgensen Kent
A calorimetric study of phosphocholine membranes mixed with desmopressin and its diacylated prodrug derivative (DPP).
International journal of pharmaceutics 2002;233(1-2):199-206.
2001: Høyrup P; Mouritsen O G; Jørgensen K
Phospholipase A(2) activity towards vesicles of DPPC and DMPC-DSPC containing small amounts of SMPC.
Biochimica et biophysica acta 2001;1515(2):133-43.
2001: Pedersen T B; Sabra M C; Frokjaer S; Mouritsen O G; Jørgensen K
Association of acylated cationic decapeptides with dipalmitoylphosphatidylserine-dipalmitoylphosphatidylcholine lipid membranes.
Chemistry and physics of lipids 2001;113(1-2):83-95.
2001: Jensen M Ø; Mouritsen O G; Peters G H
Dipolar and chain-linking effects on the rheology of grafted chains in a nanopore under shear at different grafting densities.
Physical review. E, Statistical, nonlinear, and soft matter physics 2001;64(1 Pt 1):011507.
2001: Leidy C; Wolkers W F; Jørgensen K; Mouritsen O G; Crowe J H
Lateral organization and domain formation in a two-component lipid membrane system.
Biophysical journal 2001;80(4):1819-28.
2001: Pedersen T B; Sabra M C; Frokjaer S; Mouritsen O G; Jørgensen K
Association of an acylated model peptide with DPPC-DPPS lipid membranes.
International journal of pharmaceutics 2001;214(1-2):77-81.
2001: Davidsen J; Vermehren C; Frokjaer S; Mouritsen O G; Jørgensen K
Drug delivery by phospholipase A(2) degradable liposomes.
International journal of pharmaceutics 2001;214(1-2):67-9.
2001: Kaasgaard T; Mouritsen O G; Jørgensen K
Screening effect of PEG on avidin binding to liposome surface receptors.
International journal of pharmaceutics 2001;214(1-2):63-5.
2001: Davidsen J; Vermehren C; Frøkjaer S; Mouritsen O G; Jørgensen K
Enzymatic degradation of polymer covered SOPC-liposomes in relation to drug delivery.
Advances in colloid and interface science 2001;89-90():303-11.
2001: Kaasgaard T; Mouritsen O G; Jørgensen K
Receptor mediated binding of avidin to polymer covered liposomes.
Journal of liposome research 2001;11(1):31-42.
2001: Jørgensen K; Høyrup P; Pedersen T B; Mouritsen O G
Dynamical and structural properties of lipid membranes in relation to liposomal drug delivery systems.
Cellular & molecular biology letters 2001;6(2A):255-63.
2000: Trandum C; Westh P; Jorgensen K; Mouritsen O G
A thermodynamic study of the effects of cholesterol on the interaction between liposomes and ethanol.
Biophysical journal 2000;78(5):2486-92.
2000: Holopainen J M; Lemmich J; Richter F; Mouritsen O G; Rapp G; Kinnunen P K
Dimyristoylphosphatidylcholine/C16:0-ceramide binary liposomes studied by differential scanning calorimetry and wide- and small-angle x-ray scattering.
Biophysical journal 2000;78(5):2459-69.
2000: Nielsen L K; Bjørnholm T; Mouritsen O G
Fluctuations caught in the act.
Nature 2000;404(6776):352.
2000: Sabra M C; Mouritsen O G
Monte Carlo simulations of lateral membrane organization.
Methods in enzymology 2000;321():263-78.
1999: Jørgensen K; Vermehren C; Mouritsen O G
Enhancement of phospholipase A2 catalyzed degradation of polymer grafted PEG-liposomes: effects of lipopolymer-concentration and chain-length.
Pharmaceutical research 1999;16(9):1491-3.
1999: Trandum C; Westh P; Jørgensen K; Mouritsen O G
Association of ethanol with lipid membranes containing cholesterol, sphingomyelin and ganglioside: a titration calorimetry study.
Biochimica et biophysica acta 1999;1420(1-2):179-88.
1998: Gil T; Ipsen J H; Mouritsen O G; Sabra M C; Sperotto M M; Zuckermann M J
Theoretical analysis of protein organization in lipid membranes.
Biochimica et biophysica acta 1998;1376(3):245-66.
1998: Mouritsen O G; Jørgensen K
A new look at lipid-membrane structure in relation to drug research.
Pharmaceutical research 1998;15(10):1507-19.
1998: Sabra M C; Mouritsen O G
Steady-state compartmentalization of lipid membranes by active proteins.
Biophysical journal 1998;74(2 Pt 1):745-52.
1997: Risbo J; Jørgensen K; Sperotto M M; Mouritsen O G
Phase behavior and permeability properties of phospholipid bilayers containing a short-chain phospholipid permeability enhancer.
Biochimica et biophysica acta 1997;1329(1):85-96.
1997: Dumas F; Sperotto M M; Lebrun M C; Tocanne J F; Mouritsen O G
Molecular sorting of lipids by bacteriorhodopsin in dilauroylphosphatidylcholine/distearoylphosphatidylcholine lipid bilayers.
Biophysical journal 1997;73(4):1940-53.
1997: Gil T; Sabra M C; Ipsen J H; Mouritsen O G
Wetting and capillary condensation as means of protein organization in membranes.
Biophysical journal 1997;73(4):1728-41.
1997: Baekmark T R; Pedersen S; Jørgensen K; Mouritsen O G
The effects of ethylene oxide containing lipopolymers and tri-block copolymers on lipid bilayers of dipalmitoylphosphatidylcholine.
Biophysical journal 1997;73(3):1479-91.
1997: Mouritsen O G; Jørgensen K
Small-scale lipid-membrane structure: simulation versus experiment.
Current opinion in structural biology 1997;7(4):518-27.
1997: Hønger T; Jørgensen K; Stokes D; Biltonen R L; Mouritsen O G
Phospholipase A2 activity and physical properties of lipid-bilayer substrates.
Methods in enzymology 1997;286():168-90.
1996: Nielsen M; Miao L; Ipsen J H; Jørgensen K; Zuckermann M J; Mouritsen O G
Model of a sub-main transition in phospholipid bilayers.
Biochimica et biophysica acta 1996;1283(2):170-6.
1996: Pedersen S; Jørgensen K; Baekmark T R; Mouritsen O G
Indirect evidence for lipid-domain formation in the transition region of phospholipid bilayers by two-probe fluorescence energy transfer.
Biophysical journal 1996;71(2):554-60.
1996: Hønger T; Jørgensen K; Biltonen R L; Mouritsen O G
Systematic relationship between phospholipase A2 activity and dynamic lipid bilayer microheterogeneity.
Biochemistry 1996;35(28):9003-6.
1996: Sabra M C; Jørgensen K; Mouritsen O G
Lindane suppresses the lipid-bilayer permeability in the main transition region.
Biochimica et biophysica acta 1996;1282(1):85-92.
1995: Jørgensen K; Mouritsen O G
Phase separation dynamics and lateral organization of two-component lipid membranes.
Biophysical journal 1995;69(3):942-54.
1995: Mouritsen O G; Dammann B; Fogedby H C; Ipsen J H; Jeppesen C; Jørgensen K; Risbo J; Sabra M C; Sperotto M M; Zuckermann M J
The computer as a laboratory for the physical chemistry of membranes.
Biophysical chemistry 1995;55(1-2):55-68.
1995: Mouritsen O G; Jørgensen K
Micro-, nano- and meso-scale heterogeneity of lipid bilayers and its influence on macroscopic membrane properties.
Molecular membrane biology 1995;12(1):15-20.
1995: Sabra M C; Jørgensen K; Mouritsen O G
Calorimetric and theoretical studies of the effects of lindane on lipid bilayers of different acyl chain length.
Biochimica et biophysica acta 1995;1233(1):89-104.
1994: Mouritsen O G; Jørgensen K
Dynamical order and disorder in lipid bilayers.
Chemistry and physics of lipids 1994;73(1-2):3-25.
1993: Jørgensen K; Sperotto M M; Mouritsen O G; Ipsen J H; Zuckermann M J
Phase equilibria and local structure in binary lipid bilayers.
Biochimica et biophysica acta 1993;1152(1):135-45.
1993: Jørgensen K; Ipsen J H; Mouritsen O G; Zuckermann M J
The effect of anaesthetics on the dynamic heterogeneity of lipid membranes.
Chemistry and physics of lipids 1993;65(3):205-16.
1993: Zhang Z; Sperotto M M; Zuckermann M J; Mouritsen O G
A microscopic model for lipid/protein bilayers with critical mixing.
Biochimica et biophysica acta 1993;1147(1):154-60.
1993: Mouritsen O G; Bloom M
Models of lipid-protein interactions in membranes.
Annual review of biophysics and biomolecular structure 1993;22():145-71.
1993: Sperotto M M; Mouritsen O G
Lipid enrichment and selectivity of integral membrane proteins in two-component lipid bilayers.
European biophysics journal : EBJ 1993;22(5):323-8.
1992: Corvera E; Mouritsen O G; Singer M A; Zuckermann M J
The permeability and the effect of acyl-chain length for phospholipid bilayers containing cholesterol: theory and experiment.
Biochimica et biophysica acta 1992;1107(2):261-70.
1992: Mouritsen O G; Jørgensen K
Dynamic lipid-bilayer heterogeneity: a mesoscopic vehicle for membrane function?
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(2):129-36.
1991: Jørgensen K; Ipsen J H; Mouritsen O G; Bennett D; Zuckermann M J
The effects of density fluctuations on the partitioning of foreign molecules into lipid bilayers: application to anaesthetics and insecticides.
Biochimica et biophysica acta 1991;1067(2):241-53.
1991: Mouritsen O G
Theoretical models of phospholipid phase transitions.
Chemistry and physics of lipids 1991;57(2-3):179-94.
1991: Sperotto M M; Mouritsen O G
Monte Carlo simulation studies of lipid order parameter profiles near integral membrane proteins.
Biophysical journal 1991;59(2):261-70.
1991: Jørgensen K; Ipsen J H; Mouritsen O G; Bennett D; Zuckermann M J
A general model for the interaction of foreign molecules with lipid membranes: drugs and anaesthetics.
Biochimica et biophysica acta 1991;1062(2):227-38.
1991: Jørgensen K; Ipsen J H; Mouritsen O G; Bennett D; Zuckermann M J
Anesthetics affect membrane heterogeneity.
Annals of the New York Academy of Sciences 1991;625():747-50.
1991: Sperotto M M; Mouritsen O G
Mean-field and Monte Carlo simulation studies of the lateral distribution of proteins in membranes.
European biophysics journal : EBJ 1991;19(4):157-68.
1990: Ipsen J H; Jørgensen K; Mouritsen O G
Density fluctuations in saturated phospholipid bilayers increase as the acyl-chain length decreases.
Biophysical journal 1990;58(5):1099-107.
1990: Ipsen J H; Mouritsen O G; Bloom M
Relationships between lipid membrane area, hydrophobic thickness, and acyl-chain orientational order. The effects of cholesterol.
Biophysical journal 1990;57(3):405-12.
1989: Ipsen J H; Mouritsen O G; Zuckermann M J
Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol.
Biophysical journal 1989;56(4):661-7.
1989: Cruzeiro-Hansson L; Ipsen J H; Mouritsen O G
Intrinsic molecules in lipid membranes change the lipid-domain interfacial area: cholesterol at domain interfaces.
Biochimica et biophysica acta 1989;979(2):166-76.
1989: Sperotto M M; Ipsen J H; Mouritsen O G
Theory of protein-induced lateral phase separation in lipid membranes.
Cell biophysics 1989;14(1):79-95.
1988: Ipsen J H; Mouritsen O G
Modelling the phase equilibria in two-component membranes of phospholipids with different acyl-chain lengths.
Biochimica et biophysica acta 1988;944(2):121-34.
1988: Cruzeiro-Hansson L; Mouritsen O G
Passive ion permeability of lipid membranes modelled via lipid-domain interfacial area.
Biochimica et biophysica acta 1988;944(1):63-72.
1987: Ipsen J H; Karlström G; Mouritsen O G; Wennerström H; Zuckermann M J
Phase equilibria in the phosphatidylcholine-cholesterol system.
Biochimica et biophysica acta 1987;905(1):162-72.
1985: Mouritsen O G; Zuckermann M J
Softening of lipid bilayers.
European biophysics journal : EBJ 1985;12(2):75-86.

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Ole Mouritsen

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