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Jean-François Mouscadet

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Chemicals & Drugs

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HIV-1

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Sébastien Lyonnais; Jean-François Mouscadet; Vincent Parissi; Tobias Restle; Serge Bouaziz; Jose Maria Gatell; Robert J Gorelick; Fatima Heniche-Boukhalfa; Eric Le Cam; Gilles Mirambeau
A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.
Gwenola Manic; Aurélie Maurin-Marlin; Jean-François Mouscadet; Frédéric Subra; Lorenzo Galluzzi; Stéphanie Bury-Moné
3' self-inactivating long terminal repeat inserts for the modulation of transgene expression from lentiviral vectors.
Xiaoju Ni; Osamuede Osemwota; Safwat Abdel Azeim; Rohit Arora; Vincent Calvez; Elodie Laine; Anne-Geneviève Marcelin; Jean-François Mouscadet; Luba Tchertanov
In Silico and In Vitro Comparison of HIV-1 Subtypes B and CRF02_AG Integrases Susceptibility to Integrase Strand Transfer Inhibitors.

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All Publications

2013: Sébastien Lyonnais; Jean-François Mouscadet; Vincent Parissi; Tobias Restle; Serge Bouaziz; Jose Maria Gatell; Robert J Gorelick; Fatima Heniche-Boukhalfa; Eric Le Cam; Gilles Mirambeau
A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.
Virus research 2013;171(2):287-303.
2012: Gwenola Manic; Aurélie Maurin-Marlin; Jean-François Mouscadet; Frédéric Subra; Lorenzo Galluzzi; Stéphanie Bury-Moné
3' self-inactivating long terminal repeat inserts for the modulation of transgene expression from lentiviral vectors.
Human gene therapy methods 2012;23(2):84-97.
2012: Xiaoju Ni; Osamuede Osemwota; Safwat Abdel Azeim; Rohit Arora; Vincent Calvez; Elodie Laine; Anne-Geneviève Marcelin; Jean-François Mouscadet; Luba Tchertanov
In Silico and In Vitro Comparison of HIV-1 Subtypes B and CRF02_AG Integrases Susceptibility to Integrase Strand Transfer Inhibitors.
Advances in virology 2012;2012():548657.
2011: Katarzyna Serafin; Luba Tchertanov; Andrzej Bak; Elodie Laine; Pawel Mazur; Jean-François Mouscadet; Jaroslaw Polanski
Ethyl malonate amides: a diketo acid offspring fragment for HIV integrase inhibition.
Bioorganic & medicinal chemistry 2011;19(16):5000-5.
2011: Pierre Vandurm; Allan Guiguen; Christine Cauvin; Benoît Georges; Kiet Le Van; Catherine Michaux; Christelle Cardona; Gladys Mbemba; Jean-François Mouscadet; László Hevesi; Carine Van Lint; Johan Wouters
Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: new structural insight into the HIV-1 integrase inhibition.
European journal of medicinal chemistry 2011;46(5):1749-56.
2011: Charlotte Charpentier; Bénédicte Roquebert; Olivier Delelis; Lucile Larrouy; Sophie Matheron; Roland Tubiana; Marina Karmochkine; Xavier Duval; Geneviève Chêne; Alexandre Storto; Gilles Collin; Antoine Bénard; Florence Damond; Jean-François Mouscadet; Françoise Brun-Vézinet; Diane Descamps
Hot spots of integrase genotypic changes leading to HIV-2 resistance to raltegravir.
Antimicrobial agents and chemotherapy 2011;55(3):1293-5.
2011: Charlotte Charpentier; Geneviève Chêne; Florence Damond; Olivier Delelis; Diane Descamps; Lucile Larrouy; Sophie Matheron; Jean-François Mouscadet; Françoise Brun-Vézinet; Pauline Campa
Long-lasting persistence of integrase resistance mutations in HIV-2-infected patients after raltegravir withdrawal.
Antiviral therapy 2011;16(6):937-40.
2011: Xiao-Ju Ni; Alexandre Storto; Charlotte Charpentier; Gilles Collin; Florence Damond; Olivier Delelis; Diane Descamps; Jean-François Mouscadet
G140S/Q148R and N155H mutations render HIV-2 Integrase resistant to raltegravir whereas Y143C does not.
Retrovirology 2011;8():68.
2010: Jean-François Mouscadet; Olivier Delelis; Anne-Geneviève Marcelin; Luba Tchertanov
Resistance to HIV-1 integrase inhibitors: A structural perspective.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2010;13(4-5):139-50.
2010: Cédric Maurin; Cédric Lion; Fabrice Bailly; Nadia Touati; Hervé Vezin; Gladys Mbemba; Jean-François Mouscadet; zeger debyser; Myriam Witvrouw; Philippe Cotelle
New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent.
Bioorganic & medicinal chemistry 2010;18(14):5194-201.
2010: Kevin Carayon; Hervé Leh; Etienne Henry; Françoise Simon; Jean-François Mouscadet; Eric Deprez
A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain.
Nucleic acids research 2010;38(11):3692-708.
2010: Jean-François Mouscadet; Didier Desmaële
Chemistry and structure-activity relationship of the styrylquinoline-type HIV integrase inhibitors.
Molecules (Basel, Switzerland) 2010;15(5):3048-78.
2010: Olivier Delelis; Sylvain Thierry; Frédéric Subra; Françoise Simon; Isabelle Malet; Chakib Alloui; Sophie Sayon; Vincent Calvez; Eric Deprez; Anne-Geneviève Marcelin; Luba Tchertanov; Jean-François Mouscadet
Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo.
Antimicrobial agents and chemotherapy 2010;54(1):491-501.
2009: Yves Aubert; Marcel Chassignol; Victoria Roig; Gladys Mbemba; Julien Weiss; Hervé MEUDAL; Jean-François Mouscadet; Ulysse Asseline
Synthesis and anti-HIV-1 integrase activity of modified dinucleotides.
European journal of medicinal chemistry 2009;44(12):5029-44.
2009: Jean-François Mouscadet; Rohit Arora; Joseph André; Jean-Christophe Lambry; Olivier Delelis; Isabelle Malet; Anne-Geneviève Marcelin; Vincent Calvez; Luba Tchertanov
HIV-1 IN alternative molecular recognition of DNA induced by raltegravir resistance mutations.
Journal of molecular recognition : JMR 2009;22(6):480-94.
2009: Pierre Vandurm; Christine Cauvin; Allan Guiguen; Benoît Georges; Kiet Le Van; Valérie Martinelli; Christelle Cardona; Gladys Mbemba; Jean-François Mouscadet; László Hevesi; Carine Van Lint; Johan Wouters
Structural and theoretical studies of [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoïc acid as HIV-1 integrase inhibitor.
Bioorganic & medicinal chemistry letters 2009;19(16):4806-9.
2009: Fabrice Michel; Corinne Crucifix; Florence Granger; Sylvia Eiler; Jean-François Mouscadet; Sergei Korolev; Julia Agapkina; Rustam Ziganshin; Marina Gottikh; Alexis Nazabal; Stéphane Emiliani; Richard Benarous; Dino Moras; Patrick Schultz; Marc Ruff
Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor.
The EMBO journal 2009;28(7):980-91.
2009: Isabelle Malet; Olivier Delelis; Cathia Soulie; Marc Wirden; Luba Tchertanov; Philippe Mottaz; Gilles Peytavin; Christine Katlama; Jean-François Mouscadet; Vincent Calvez; Anne-Geneviève Marcelin
Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients.
The Journal of antimicrobial chemotherapy 2009;63(4):795-804.
2009: Olivier Delelis; Isabelle Malet; Li Na; Luba Tchertanov; Vincent Calvez; Anne-Genevieve Marcelin; Frederic Subra; Eric Deprez; Jean-François Mouscadet
The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation.
Nucleic acids research 2009;37(4):1193-201.
2009: Almoustapha-Issiaka Maïga; Isabelle Malet; Cathia Soulie; Anne Derache; Victoria Koita; Bahia Amellal; Luba Tchertanov; Olivier Delelis; Laurence Morand-Joubert; Jean-François Mouscadet; Robert Murphy; Mamadou Cissé; Christine Katlama; Vincent Calvez; Anne-Geneviève Marcelin
Genetic barriers for integrase inhibitor drug resistance in HIV type-1 B and CRF02_AG subtypes.
Antiviral therapy 2009;14(1):123-9.
2008: Muriel Billamboz; Fabrice Bailly; Maria Letizia Barreca; Laura De Luca; Jean-François Mouscadet; Christina Calmels; Marie-Line Andréola; Myriam Witvrouw; Frauke Christ; zeger debyser; Philippe Cotelle
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.
Journal of medicinal chemistry 2008;51(24):7717-30.
2008: Olivier Delelis; Kevin Carayon; Elvire Guiot; Hervé Leh; Patrick TAUC; Jean-Claude Brochon; Jean-François Mouscadet; Eric Deprez
Insight into the integrase-DNA recognition mechanism. A specific DNA-binding mode revealed by an enzymatically labeled integrase.
The Journal of biological chemistry 2008;283(41):27838-49.
2008: Clémence Queffélec; Fabrice Bailly; Gladys Mbemba; Jean-François Mouscadet; zeger debyser; Myriam Witvrouw; Philippe Cotelle
The total synthesis of fukiic acid, an HIV-1 integrase inhibitor.
European journal of medicinal chemistry 2008;43(10):2268-71.
2008: Clémence Queffélec; Fabrice Bailly; Gladys Mbemba; Jean-François Mouscadet; Sean Hayes; zeger debyser; Myriam Witvrouw; Philippe Cotelle
Synthesis and antiviral properties of some polyphenols related to Salvia genus.
Bioorganic & medicinal chemistry letters 2008;18(16):4736-40.
2008: Fabrice Bailly; Clémence Queffélec; Gladys Mbemba; Jean-François Mouscadet; Nicole Pommery; Jean Pommery; Jean-Pierre Hénichart; Philippe Cotelle
Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones.
European journal of medicinal chemistry 2008;43(6):1222-9.
2008: Isabelle Malet; Cathia Soulie; Luba Tchertanov; Anne Derache; Bahia Amellal; Ousmane Traore; Anne Simon; Christine Katlama; Jean-François Mouscadet; Vincent Calvez; Anne-Geneviève Marcelin
Structural effects of amino acid variations between B and CRF02-AG HIV-1 integrases.
Journal of medical virology 2008;80(5):754-61.
2008: Mélanie Dubois; Fabrice Bailly; Gladys Mbemba; Jean-François Mouscadet; zeger debyser; Myriam Witvrouw; Philippe Cotelle
Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents.
Journal of medicinal chemistry 2008;51(8):2575-9.
2008: Isabelle Malet; Olivier Delelis; Marc-Antoine Valantin; Brigitte Montes; Cathia Soulie; Marc Wirden; Luba Tchertanov; Gilles Peytavin; Jacques Reynes; Jean-François Mouscadet; Christine Katlama; Vincent Calvez; Anne-Geneviève Marcelin
Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro.
Antimicrobial agents and chemotherapy 2008;52(4):1351-8.
2008: Olivier Delelis; Kevin Carayon; Ali Saïb; Eric Deprez; Jean-François Mouscadet
Integrase and integration: biochemical activities of HIV-1 integrase.
Retrovirology 2008;5():114.
2007: Chih-Chia Chiang; Jean-François Mouscadet; Hou-Jen Tsai; Chi-Tsan Liu; Ling-Yih Hsu
Synthesis and HIV-1 integrase inhibition of novel bis- or tetra-coumarin analogues.
Chemical & pharmaceutical bulletin 2007;55(12):1740-3.
2007: Christel Masson; Stéphanie Bury-Moné; Elvire Guiot; Asier Saez-Cirion; Damien Schoëvaërt-Brossault; Corinne Brachet-Ducos; Olivier Delelis; Frédéric Subra; Laurence Jeanson-Leh; Jean-François Mouscadet
Ku80 participates in the targeting of retroviral transgenes to the chromatin of CHO cells.
Journal of virology 2007;81(15):7924-32.
2007: Luba Tchertanov; Jean-François Mouscadet
Target recognition by catechols and beta-ketoenols: potential contribution of hydrogen bonding and Mn/Mg chelation to HIV-1 integrase inhibition.
Journal of medicinal chemistry 2007;50(6):1133-45.
2007: veljko veljkovic; Jean-François Mouscadet; Nevena Veljkovic; Sanja Glisic; zeger debyser
Simple criterion for selection of flavonoid compounds with anti-HIV activity.
Bioorganic & medicinal chemistry letters 2007;17(5):1226-32.
2007: Michael G Thomas; giovanni maga; Jean-François Mouscadet; Nicola M Howarth
Investigation of novel lipid-functionalized PNA monomers as potential HIV-1 non-nucleoside reverse transcriptase and/or integrase inhibitors.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1063-6.
2007: Olivier Delelis; Vincent Parissi; Hervé Leh; Gladys Mbemba; Caroline Petit; Pierre Sonigo; Eric Deprez; Jean-François Mouscadet
Efficient and specific internal cleavage of a retroviral palindromic DNA sequence by tetrameric HIV-1 integrase.
PloS one 2007;2(7):e608.
2006: Halina Niedbala; Jaroslaw Polanski; Rafal Gieleciak; Robert Musiol; Dominik Tabak; Barbara Podeszwa; Andrzej Bak; Anna Palka; Jean-François Mouscadet; Johann Gasteiger; Marc Le Bret
Comparative molecular surface analysis (CoMSA) for virtual combinatorial library screening of styrylquinoline HIV-1 blocking agents.
Combinatorial chemistry & high throughput screening 2006;9(10):753-70.
2006: Annie David; Asier Sáez-Cirión; Pierre Versmisse; Odile Malbec; Bruno Iannascoli; Florence Herschke; Marianne Lucas; Françoise Barré-Sinoussi; Jean-François Mouscadet; Marc Daëron; Gianfranco Pancino
The engagement of activating FcgammaRs inhibits primate lentivirus replication in human macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6291-300.
2006: Elvire Guiot; Kevin Carayon; Olivier Delelis; Françoise Simon; Patrick TAUC; Eugeny M Zubin; Marina Gottikh; Jean-François Mouscadet; Jean-Claude Brochon; Eric Deprez
Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity.
The Journal of biological chemistry 2006;281(32):22707-19.
2006: Marlène Maroun; Olivier Delelis; Gael COADOU; Thomas Bader; Emmanuel Ségéral; Gladys Mbemba; Caroline Petit; Pierre Sonigo; Jean-Christophe Rain; Jean-François Mouscadet; Richard Benarous; Stéphane Emiliani
Inhibition of early steps of HIV-1 replication by SNF5/Ini1.
The Journal of biological chemistry 2006;281(32):22736-43.
2006: Chang-Xiao Su; Jean-François Mouscadet; Chih-Chia Chiang; Hou-Jen Tsai; Ling-Yih Hsu
HIV-1 integrase inhibition of biscoumarin analogues.
Chemical & pharmaceutical bulletin 2006;54(5):682-6.
2006: Cédric Maurin; Fabrice Bailly; Gladys Mbemba; Jean-François Mouscadet; Philippe Cotelle
Design, synthesis, and anti-integrase activity of catechol-DKA hybrids.
Bioorganic & medicinal chemistry 2006;14(9):2978-84.
2006: Julia Agapkina; Maksim Smolov; Sophie Barbe; Eugeny M Zubin; Timofei S Zatsepin; Eric Deprez; Marc Le Bret; Jean-François Mouscadet; Marina Gottikh
Probing of HIV-1 integrase/DNA interactions using novel analogs of viral DNA.
The Journal of biological chemistry 2006;281(17):11530-40.
2006: Maksim Smolov; Marina Gottikh; Vadim Tashlitskii; Sergei Korolev; Ilya Demidyuk; Jean-Claude Brochon; Jean-François Mouscadet; Eric Deprez
Kinetic study of the HIV-1 DNA 3'-end processing.
The FEBS journal 2006;273(6):1137-51.
2006: Katarzyna Majerz-Maniecka; Robert Musiol; Wojciech Nitek; Barbara J Oleksyn; Jean-François Mouscadet; Marc Le Bret; Jaroslaw Polanski
Intermolecular interactions in the crystal structures of potential HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(4):1005-9.
2005: Joël Didierjean; Catherine Isel; Flore Querré; Jean-François Mouscadet; Anne-Marie Aubertin; Jean-Yves Valnot; Serge R Piettre; Roland Marquet
Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones.
Antimicrobial agents and chemotherapy 2005;49(12):4884-94.
2005: Fabrice Bailly; Clémence Queffelec; Gladys Mbemba; Jean-François Mouscadet; Philippe Cotelle
Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis.
Bioorganic & medicinal chemistry letters 2005;15(22):5053-6.
2005: Marie Normand-Bayle; Christophe Bénard; Fatima Zouhiri; Jean-François Mouscadet; Hervé Leh; Claire-Marie Thomas; Gladys Mbemba; Didier Desmaële; Jean d'Angelo
New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: synthesis and biological activity.
Bioorganic & medicinal chemistry letters 2005;15(18):4019-22.
2005: Olivier Delelis; Caroline Petit; Hervé Leh; Gladys Mbemba; Jean-François Mouscadet; Pierre Sonigo
A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles.
Retrovirology 2005;2():31.
2004: Cédric Maurin; Fabrice Bailly; Eric Buisine; Hervé Vezin; Gladys Mbemba; Jean-François Mouscadet; Philippe Cotelle
Spectroscopic studies of diketoacids-metal interactions. A probing tool for the pharmacophoric intermetallic distance in the HIV-1 integrase active site.
Journal of medicinal chemistry 2004;47(22):5583-6.
2004: Aurélie Mousnier; Hervé Leh; Jean-François Mouscadet; Catherine Dargemont
Nuclear import of HIV-1 integrase is inhibited in vitro by styrylquinoline derivatives.
Molecular pharmacology 2004;66(4):783-8.
2004: Iu Iu Agapkina; V N Tashlitskiĭ; Eric Deprez; Jean-Claude Brochon; A V Shugaliĭ; Jean-François Mouscadet; Marina Gottikh
[Interactions of HIV-1 DNA heterocyclic bases with viral DNA].
Molekuliarnaia biologiia 2004;38(5):848-57.
2004: Marina Pinskaya; Elena A Romanova; Eugeny M Volkov; Eric Deprez; Hervé Leh; Jean-Claude Brochon; Jean-François Mouscadet; Marina Gottikh
HIV-1 integrase complexes with DNA dissociate in the presence of short oligonucleotides conjugated to acridine.
Biochemistry 2004;43(27):8735-43.
2004: Sabine Bonnenfant; Claire Marie Thomas; Claudio Vita; Frédéric Subra; Eric Deprez; Fatima Zouhiri; Didier Desmaële; Jean d'Angelo; Jean-François Mouscadet; Hervé Leh
Styrylquinolines, integrase inhibitors acting prior to integration: a new mechanism of action for anti-integrase agents.
Journal of virology 2004;78(11):5728-36.
2004: Christophe Bénard; Fatima Zouhiri; Marie Normand-Bayle; Michèle Danet; Didier Desmaële; Hervé Leh; Jean-François Mouscadet; Gladys Mbemba; Claire-Marie Thomas; Sabine Bonnenfant; Marc Le Bret; Jean d'Angelo
Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity.
Bioorganic & medicinal chemistry letters 2004;14(10):2473-6.
2004: Marina Pinskaya; M E Volkov; Elena A Romanova; Eugeny M Volkov; Jean-François Mouscadet; Marina Gottikh
Oligonucleotides conjugated with acridine: a new type of fluorescence probes for DNA hybridization assay.
Doklady. Biochemistry and biophysics 2004;394():35-8.
2004: Eric Deprez; Sophie Barbe; Macieij Kolaski; Hervé Leh; Fatima Zouhiri; Christian Auclair; Jean-Claude Brochon; Marc Le Bret; Jean-François Mouscadet
Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro.
Molecular pharmacology 2004;65(1):85-98.
2004: Julia Agapkina; Maksim Smolov; Eugeny M Zubin; Jean-François Mouscadet; Marina Gottikh
HIV-1 integrase can process a 3'-end crosslinked substrate.
European journal of biochemistry / FEBS 2004;271(1):205-11.
2003: Sébastien Violot; Saw See Hong; Dina Rakotobe; Caroline Petit; Bernard Gay; Karen Moreau; Geneviève Billaud; Stéphane Priet; Joséphine Sire; Olivier Schwartz; Jean-François Mouscadet; Pierre Boulanger
The human polycomb group EED protein interacts with the integrase of human immunodeficiency virus type 1.
Journal of virology 2003;77(23):12507-22.
2003: Mohammed A Fakhfakh; Alain Fournet; Eric Prina; Jean-François Mouscadet; Xavier Franck; Reynald Hocquemiller; Bruno Figadère
Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections.
Bioorganic & medicinal chemistry 2003;11(23):5013-23.
2003: Julien Bischerour; Patrick TAUC; Hervé Leh; Hugues de Rocquigny; Bernard P Roques; Jean-François Mouscadet
The (52-96) C-terminal domain of Vpr stimulates HIV-1 IN-mediated homologous strand transfer of mini-viral DNA.
Nucleic acids research 2003;31(10):2694-702.
2003: Julien Bischerour; Hervé Leh; Eric Deprez; Jean-Claude Brochon; Jean-François Mouscadet
Disulfide-linked integrase oligomers involving C280 residues are formed in vitro and in vivo but are not essential for human immunodeficiency virus replication.
Journal of virology 2003;77(1):135-41.
2002: Pili Chih-Min Mao; Jean-François Mouscadet; Hervé Leh; Christian Auclair; Ling-Yih Hsu
Chemical modification of coumarin dimer and HIV-1 integrase inhibitory activity.
Chemical & pharmaceutical bulletin 2002;50(12):1634-7.
2002: Jaroslaw Polanski; Fatima Zouhiri; Laurence Jeanson; Didier Desmaële; Jean d'Angelo; Jean-François Mouscadet; Rafal Gieleciak; Johann Gasteiger; Marc Le Bret
Use of the Kohonen neural network for rapid screening of ex vivo anti-HIV activity of styrylquinolines.
Journal of medicinal chemistry 2002;45(21):4647-54.
2002: Laurence Jeanson; Frédéric Subra; Sabine Vaganay; Martial Hervy; Elizabeth Marangoni; Jean Bourhis; Jean-François Mouscadet
Effect of Ku80 depletion on the preintegrative steps of HIV-1 replication in human cells.
Virology 2002;300(1):100-8.
2002: Laurence Jeanson; Jean-François Mouscadet
Ku represses the HIV-1 transcription: identification of a putative Ku binding site homologous to the mouse mammary tumor virus NRE1 sequence in the HIV-1 long terminal repeat.
The Journal of biological chemistry 2002;277(7):4918-24.
2002: Priscille Brodin; Marina Pinskaya; Malcolm Buckle; Uwe Parsch; Elena A Romanova; Joachim W Engels; Marina Gottikh; Jean-François Mouscadet
Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides.
Biochemistry 2002;41(5):1529-38.
2001: R Dupont; Laurence Jeanson; Jean-François Mouscadet; Philippe Cotelle
Synthesis and HIV-1 integrase inhibitory activities of catechol and bis-catechol derivatives.
Bioorganic & medicinal chemistry letters 2001;11(24):3175-8.
2001: Richard G Maroun; S Gayet; M S Benleulmi; Horea Porumb; Loussinée Zargarian; Hayate Merad; Hervé Leh; Jean-François Mouscadet; Frédéric Troalen; Serge Fermandjian
Peptide inhibitors of HIV-1 integrase dissociate the enzyme oligomers.
Biochemistry 2001;40(46):13840-8.
2001: Eric Deprez; Patrick TAUC; Hervé Leh; Jean-François Mouscadet; Christian Auclair; M E Hawkins; Jean-Claude Brochon
DNA binding induces dissociation of the multimeric form of HIV-1 integrase: a time-resolved fluorescence anisotropy study.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10090-5.
2001: Cyril Laboulais; Eric Deprez; Hervé Leh; Jean-François Mouscadet; Jean-Claude Brochon; Marc Le Bret
HIV-1 integrase catalytic core: molecular dynamics and simulated fluorescence decays.
Biophysical journal 2001;81(1):473-89.
2001: Priscille Brodin; Marina Pinskaya; Uwe Parsch; Julien Bischerour; Hervé Leh; Elena A Romanova; Joachim W Engels; Marina Gottikh; Jean-François Mouscadet
6-oxocytidine containing oligonucleotides inhibit the HIV-1 integrase in vitro.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):481-6.
2001: Jean d'Angelo; Jean-François Mouscadet; Didier Desmaële; Fatima Zouhiri; Hervé Leh
HIV-1 integrase: the next target for AIDS therapy?
Pathologie-biologie 2001;49(3):237-46.
2000: M D Pinskaia; Priscille Brodin; Elena A Romanova; Eugeny M Volkov; Jean-François Mouscadet; M V Gottikh
[Inhibition of integration of human immunodeficiency virus DNA, modified by oligonucleotides].
Molekuliarnaia biologiia 2000;34(6):1039-45.
2000: Hervé Leh; Priscille Brodin; Julien Bischerour; Eric Deprez; Patrick TAUC; Jean-Claude Brochon; Eric LeCam; Dominique Coulaud; Christian Auclair; Jean-François Mouscadet
Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase.
Biochemistry 2000;39(31):9285-94.
2000: Eric Deprez; Patrick TAUC; Hervé Leh; Jean-François Mouscadet; Christian Auclair; Jean-Claude Brochon
Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy.
Biochemistry 2000;39(31):9275-84.
2000: Hugues de Rocquigny; A Caneparo; T Delaunay; Julien Bischerour; Jean-François Mouscadet; Bernard P Roques
Interactions of the C-terminus of viral protein R with nucleic acids are modulated by its N-terminus.
European journal of biochemistry / FEBS 2000;267(12):3654-60.
2000: Mohammed Ouali; Cyril Laboulais; Hervé Leh; D Gill; Didier Desmaële; K Mekouar; Fatima Zouhiri; Jean d'Angelo; Christian Auclair; Jean-François Mouscadet; Marc Le Bret
Modeling of the inhibition of retroviral integrases by styrylquinoline derivatives.
Journal of medicinal chemistry 2000;43(10):1949-57.
2000: Fatima Zouhiri; Jean-François Mouscadet; K Mekouar; Didier Desmaële; D Savouré; Hervé Leh; Frédéric Subra; Marc Le Bret; Christian Auclair; Jean d'Angelo
Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture.
Journal of medicinal chemistry 2000;43(8):1533-40.
2000: Mohammed Ouali; Cyril Laboulais; Hervé Leh; D Gill; E Xhuvani; Fatima Zouhiri; D Desmaele; Jean d'Angelo; Christian Auclair; Jean-François Mouscadet; Marc Le Bret
Tautomers of styrylquinoline derivatives containing a methoxy substituent: computation of their population in aqueous solution and their interaction with RSV integrase catalytic core.
Acta biochimica Polonica 2000;47(1):11-22.
1999: Priscille Brodin; Marina Pinskaya; Eugeny M Volkov; Elena A Romanova; Hervé Leh; Christian Auclair; Jean-François Mouscadet; Marina Gottikh
Branched oligonucleotide-intercalator conjugate forming a parallel stranded structure inhibits HIV-1 integrase.
FEBS letters 1999;460(2):270-4.
1999: Priscille Brodin; J S Sun; Jean-François Mouscadet; Christian Auclair
Optimization of alternate-strand triple helix formation at the 5"-TpA-3" and 5"-ApT-3" junctions.
Nucleic acids research 1999;27(15):3029-34.
1999: Priscille Brodin; Marina Gottikh; Christian Auclair; Jean-François Mouscadet
Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides.
Nucleosides & nucleotides 1999;18(6-7):1717-8.
1999: P Bouillé; Frédéric Subra; Jean-François Mouscadet; Christian Auclair
Antisense-mediated repression of DNA topoisomerase II expression leads to an impairment of HIV-1 replicative cycle.
Journal of molecular biology 1999;285(3):945-54.
1998: K Mekouar; Jean-François Mouscadet; Didier Desmaële; Frédéric Subra; Hervé Leh; D Savouré; Christian Auclair; Jean d'Angelo
Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells.
Journal of medicinal chemistry 1998;41(15):2846-57.
1997: S Carteau; S C Batson; Leonora Poljak; Jean-François Mouscadet; Hugues de Rocquigny; Jean-Luc Darlix; Bernard P Roques; Emmanuel Käs; Christian Auclair
Human immunodeficiency virus type 1 nucleocapsid protein specifically stimulates Mg2+-dependent DNA integration in vitro.
Journal of virology 1997;71(8):6225-9.
1996: M Bouziane; D I Cherny; Jean-François Mouscadet; Christian Auclair
Alternate strand DNA triple helix-mediated inhibition of HIV-1 U5 long terminal repeat integration in vitro.
The Journal of biological chemistry 1996;271(17):10359-64.
1994: Jean-François Mouscadet; S Carteau; H Goulaouic; Frédéric Subra; Christian Auclair
Triplex-mediated inhibition of HIV DNA integration in vitro.
The Journal of biological chemistry 1994;269(34):21635-8.
1994: S Carteau; Jean-François Mouscadet; H Goulaouic; Frédéric Subra; Christian Auclair
Inhibition of the in vitro integration of Moloney murine leukemia virus DNA by the DNA minor groove binder netropsin.
Biochemical pharmacology 1994;47(10):1821-6.
1994: H Goulaouic; Frédéric Subra; Jean-François Mouscadet; S Carteau; Christian Auclair
Potentiation of 2',3'-dideoxycytidine (ddC) by hydroxyurea and thymidine on the Moloney murine leukemia virus (MoMLV) early replicative steps.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1994;317(5):430-6.
1994: Jean-François Mouscadet; C Ketterlé; H Goulaouic; S Carteau; Frédéric Subra; Marc Le Bret; Christian Auclair
Triple helix formation with short oligonucleotide-intercalator conjugates matching the HIV-1 U3 LTR end sequence.
Biochemistry 1994;33(14):4187-96.
1994: H Goulaouic; Frédéric Subra; Jean-François Mouscadet; S Carteau; Christian Auclair
Exogenous nucleosides promote the completion of MoMLV DNA synthesis in G0-arrested Balb c/3T3 fibroblasts.
Virology 1994;200(1):87-97.
1994: H Goulaouic; S Carteau; Frédéric Subra; Jean-François Mouscadet; Christian Auclair; J S Sun
Selective binding to polynucleotides of the hybrid intercalating groove binder bis(pyrrolecarboxamide)-oxazolopyridocarbazole: a molecular modeling study.
Biochemistry 1994;33(6):1412-8.
1993: S Carteau; Jean-François Mouscadet; H Goulaouic; Frédéric Subra; Christian Auclair
Inhibitory effect of the polyanionic drug suramin on the in vitro HIV DNA integration reaction.
Archives of biochemistry and biophysics 1993;305(2):606-10.
1993: S Carteau; Jean-François Mouscadet; H Goulaouic; Frédéric Subra; Christian Auclair
Effect of topoisomerase inhibitors on the in vitro HIV DNA integration reaction.
Biochemical and biophysical research communications 1993;192(3):1409-14.
1993: S Carteau; Jean-François Mouscadet; H Goulaouic; Frédéric Subra; Christian Auclair
Quantitative in vitro assay for human immunodeficiency virus deoxyribonucleic acid integration.
Archives of biochemistry and biophysics 1993;300(2):756-60.
1993: Frédéric Subra; Jean-François Mouscadet; M Lavignon; C Roy; Christian Auclair
Inhibition of the Moloney murine leukemia virus cycle at a post reverse transcriptional step by the netropsin-intercalating hybrid molecule netropsin-oxazolopyridocarbazole.
Biochemical pharmacology 1993;45(1):93-9.