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Aristidis Moustakas

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Stefan Termén; E-Jean Tan; Carl-Henrik Heldin; Aristidis Moustakas
p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β.
Giuseppe Coppotelli; Nico P Dantuma; Martijn S Luijsterburg; Laia Caja; Simone Callegari; Aristidis Moustakas; Nouman Mughal; Ramakrishna Sompallae; Maria G Masucci
The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins.
Aristidis Moustakas; Carl-Henrik Heldin
Induction of epithelial-mesenchymal transition by transforming growth factor β.

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All Publications

2013: Stefan Termén; E-Jean Tan; Carl-Henrik Heldin; Aristidis Moustakas
p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β.
Journal of cellular physiology 2013;228(4):801-13.
2013: Giuseppe Coppotelli; Nico P Dantuma; Martijn S Luijsterburg; Laia Caja; Simone Callegari; Aristidis Moustakas; Nouman Mughal; Ramakrishna Sompallae; Maria G Masucci
The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins.
Nucleic acids research 2013;41(5):2950-62.
2012: Aristidis Moustakas; Carl-Henrik Heldin
Induction of epithelial-mesenchymal transition by transforming growth factor β.
Seminars in cancer biology 2012;22(5-6):446-54.
2012: Carl-Henrik Heldin; Michael Vanlandewijck; Aristidis Moustakas
Regulation of EMT by TGFβ in cancer.
FEBS letters 2012;586(14):1959-70.
2012: Agata Zieba; Carl-Henrik Heldin; Lena Lindbom; Aristidis Moustakas; Erik Nyström; Katerina Pardali; Ola Söderberg; Ulf Landegren
Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase.
Molecular & cellular proteomics : MCP 2012;11(7):M111.013482.
2012: E Papadimitriou; D Iliopoulos; D Kardassis; Aristidis Moustakas; E Vasilaki; C Vorvis; C Stournaras
Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition.
Oncogene 2012;31(23):2862-75.
2012: Peter Lönn; Carl-Henrik Heldin; Katarzyna Kowanetz; Marcin Kowanetz; Erna Raja; Michael Vanlandewijck; Eleftheria Vasilaki; Yukihide Watanabe; Aristidis Moustakas
Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.
The Journal of biological chemistry 2012;287(16):12867-78.
2012: E-Jean Tan; Sylvie Thuault; Laia Caja; Tea Carletti; Carl-Henrik Heldin; Aristidis Moustakas
Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition.
The Journal of biological chemistry 2012;287(10):7134-45.
2012: Laia Caja; Kaoru Kahata; Aristidis Moustakas
Context-dependent action of transforming growth factor β family members on normal and cancer stem cells.
Current pharmaceutical design 2012;18(27):4072-86.
2011: Zhike Zi; Zipei Feng; Douglas A Chapnick; Markus Dahl; Difan Deng; Edda Klipp; Aristidis Moustakas; Xuedong Liu
Quantitative analysis of transient and sustained transforming growth factor-β signaling dynamics.
Molecular systems biology 2011;7():492.
2011: Lars P van der Heide; Maarten van Dinther; Aristidis Moustakas; Peter ten Dijke
TGFbeta activates mitogen- and stress-activated protein kinase-1 (MSK1) to attenuate cell death.
The Journal of biological chemistry 2011;286(7):5003-11.
2011: Anita Morén; Erna Raja; Carl-Henrik Heldin; Aristidis Moustakas
Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1.
The Journal of biological chemistry 2011;286(1):341-53.
2011: Elsa Papadimitriou; Dimitris Kardassis; Aristidis Moustakas; Christos Stournaras
TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;28(2):229-38.
2011: Jonas Sjölund; Anna-Karin Boström; Erik Fredlund; Martin Johansson; David Lindgren; Börje Ljungberg; Sugata Manna; Aristidis Moustakas; Håkan Axelson
The notch and TGF-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma.
PloS one 2011;6(8):e23057.
2010: Peter Lönn; Lars P van der Heide; Markus Dahl; Ulf Hellman; Carl-Henrik Heldin; Aristidis Moustakas
PARP-1 attenuates Smad-mediated transcription.
Molecular cell 2010;40(4):521-32.
2010: Rosita Bergström; Katia Savary; Anita Morén; Sylvain Guibert; Carl-Henrik Heldin; Rolf Ohlsson; Aristidis Moustakas
Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.
The Journal of biological chemistry 2010;285(26):19727-37.
2010: Aristidis Moustakas
Integrins open the way to epithelial-mesenchymal transitions.
Cell cycle (Georgetown, Tex.) 2010;9(9):1682.
2009: Aristidis Moustakas; Carl-Henrik Heldin
The regulation of TGFbeta signal transduction.
Development (Cambridge, England) 2009;136(22):3699-714.
2009: Theresa Vincent; Etienne P A Neve; Jill R Johnson; Alexander Kukalev; Federico Rojo; Joan Albanell; Kristian Pietras; Ismo Virtanen; Lennart Philipson; Philip L Leopold; Ronald G Crystal; Antonio Garcia de Herreros; Aristidis Moustakas; Ralf F Pettersson; Jonas Fuxe
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition.
Nature cell biology 2009;11(8):943-50.
2009: Dimitris Kardassis; Carol Murphy; Theodore Fotsis; Aristidis Moustakas; Christos Stournaras
Control of transforming growth factor beta signal transduction by small GTPases.
The FEBS journal 2009;276(11):2947-65.
2009: Carl-Henrik Heldin; Marène Landström; Aristidis Moustakas
Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition.
Current opinion in cell biology 2009;21(2):166-76.
2009: Jean Christopher Chamcheu; Elizabeth Pavez Lorié; Baki Akgul; Elin Bannbers; Marie Virtanen; Luke Gammon; Aristidis Moustakas; Harshad Navsaria; Anders Vahlquist; Hans Törmä
Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines: trimethylamine N-oxide protects the keratin cytoskeleton against disruptive stress condition.
Journal of dermatological science 2009;53(3):198-206.
2009: Lukasz Huminiecki; Leon Goldovsky; Shiri Freilich; Aristidis Moustakas; Christos Ouzounis; Carl-Henrik Heldin
Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom.
BMC evolutionary biology 2009;9():28.
2009: Peter Lönn; Anita Morén; Erna Raja; Markus Dahl; Aristidis Moustakas
Regulating the stability of TGFbeta receptors and Smads.
Cell research 2009;19(1):21-35.
2008: Marcin Kowanetz; Peter Lönn; Michael Vanlandewijck; Katarzyna Kowanetz; Carl-Henrik Heldin; Aristidis Moustakas
TGFbeta induces SIK to negatively regulate type I receptor kinase signaling.
The Journal of cell biology 2008;182(4):655-62.
2008: Aristidis Moustakas; Carl-Henrik Heldin
Dynamic control of TGF-beta signaling and its links to the cytoskeleton.
FEBS letters 2008;582(14):2051-65.
2008: A Gal; Tobias Sjöblom; Ludmila Fedorova; Stefan Imreh; H Beug; Aristidis Moustakas
Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis.
Oncogene 2008;27(9):1218-30.
2007: Aristidis Moustakas; Carl-Henrik Heldin
Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression.
Cancer science 2007;98(10):1512-20.
2007: Ulrich Valcourt; Sylvie Thuault; Katerina Pardali; Carl-Henrik Heldin; Aristidis Moustakas
Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.
Molecular oncology 2007;1(1):55-71.
2007: Hideki Niimi; Katerina Pardali; Michael Vanlandewijck; Carl-Henrik Heldin; Aristidis Moustakas
Notch signaling is necessary for epithelial growth arrest by TGF-beta.
The Journal of cell biology 2007;176(5):695-707.
2007: Katerina Pardali; Aristidis Moustakas
Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer.
Biochimica et biophysica acta 2007;1775(1):21-62.
2006: Sylvie Thuault; Ulrich Valcourt; Maj Petersen; Guidalberto Manfioletti; Carl-Henrik Heldin; Aristidis Moustakas
Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition.
The Journal of cell biology 2006;174(2):175-83.
2006: Carl-Henrik Heldin; Aristidis Moustakas
A new twist in Smad signaling.
Developmental cell 2006;10(6):685-6.
2006: Akira Kurisaki; Keiko Kurisaki; Marcin Kowanetz; Hiromu Sugino; Yoshihiro Yoneda; Carl-Henrik Heldin; Aristidis Moustakas
The mechanism of nuclear export of Smad3 involves exportin 4 and Ran.
Molecular and cellular biology 2006;26(4):1318-32.
2005: Aristidis Moustakas; Carl-Henrik Heldin
Non-Smad TGF-beta signals.
Journal of cell science 2005;118(Pt 16):3573-84.
2005: Theocharis Panaretakis; Edward Laane; Katja Pokrovskaja; Ann-Charlotte Björklund; Aristidis Moustakas; Boris Zhivotovsky; Mats Heyman; Maria C Shoshan; Dan Grandér
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.
Molecular biology of the cell 2005;16(8):3821-31.
2005: Katerina Pardali; Marcin Kowanetz; Carl-Henrik Heldin; Aristidis Moustakas
Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(WAF1/Cip1).
Journal of cellular physiology 2005;204(1):260-72.
2005: Yoshinori Takahashi; Lingli Li; Masaru Kamiryo; Trias Asteriou; Aristidis Moustakas; Hidetoshi Yamashita; Paraskevi Heldin
Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner.
The Journal of biological chemistry 2005;280(25):24195-204.
2005: Anita Morén; Takeshi Imamura; Kohei Miyazono; Carl-Henrik Heldin; Aristidis Moustakas
Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.
The Journal of biological chemistry 2005;280(23):22115-23.
2005: Ulrich Valcourt; Marcin Kowanetz; Hideki Niimi; Carl-Henrik Heldin; Aristidis Moustakas
TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition.
Molecular biology of the cell 2005;16(4):1987-2002.
2005: Lina Vardouli; Aristidis Moustakas; Christos Stournaras
LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta.
The Journal of biological chemistry 2005;280(12):11448-57.
2004: Marcin Kowanetz; Ulrich Valcourt; Rosita Bergström; Carl-Henrik Heldin; Aristidis Moustakas
Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein.
Molecular and cellular biology 2004;24(10):4241-54.
2004: Marek Dudas; Andre Nagy; Nicholas J Laping; Aristidis Moustakas; Vesa Kaartinen
Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway.
Developmental biology 2004;266(1):96-108.
2004: Nieves Ibarrola; Irina Kratchmarova; Daisuke Nakajima; William P Schiemann; Aristidis Moustakas; Akhilesh Pandey; Matthias Mann
Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling.
BMC cell biology 2004;5():2.
2003: Aristidis Moustakas; Carl-Henrik Heldin
Ecsit-ement on the crossroads of Toll and BMP signal transduction.
Genes & development 2003;17(23):2855-9.
2003: Aristidis Moustakas; Carl-Henrik Heldin
The nuts and bolts of IRF structure.
Nature structural biology 2003;10(11):874-6.
2003: Anita Morén; Ulf Hellman; Yuri Inada; Takeshi Imamura; Carl-Henrik Heldin; Aristidis Moustakas
Differential ubiquitination defines the functional status of the tumor suppressor Smad4.
The Journal of biological chemistry 2003;278(35):33571-82.
2003: Keiko Kurisaki; Akira Kurisaki; Ulrich Valcourt; Alexei A Terentiev; Katerina Pardali; Peter ten Dijke; Carl-Henrik Heldin; Johan Ericsson; Aristidis Moustakas
Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation.
Molecular and cellular biology 2003;23(13):4494-510.
2003: Wan-Chih Chou; Vassiliki Prokova; Keiko Shiraishi; Ulrich Valcourt; Aristidis Moustakas; Margarita Hadzopoulou-Cladaras; Vassilis I Zannis; Dimitris Kardassis
Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4.
Molecular biology of the cell 2003;14(3):1279-94.
2003: Susumu Itoh; Midory Thorikay; Marcin Kowanetz; Aristidis Moustakas; Fumiko Itoh; Carl-Henrik Heldin; Peter ten Dijke
Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses.
The Journal of biological chemistry 2003;278(6):3751-61.
2003: Noora Kaivo-oja; Jonas Bondestam; Meerit Kämäräinen; Janne Koskimies; Ursula Vitt; Mark Cranfield; Kaisa Vuojolainen; Janne P Kallio; Vesa M Olkkonen; Masaru Hayashi; Aristidis Moustakas; nigel P groome; Peter ten Dijke; Aaron J W Hsueh; Olli Ritvos
Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells.
The Journal of clinical endocrinology and metabolism 2003;88(2):755-62.
2002: Ulrich Kintscher; Christopher Lyon; Shu Wakino; Dennis Bruemmer; Xu Feng; Stephan Goetze; Kristof Graf; Aristidis Moustakas; Bart Staels; Eckart Fleck; Willa A Hsueh; Ronald E Law
PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4.
Circulation research 2002;91(11):e35-44.
2002: George Koutsodontis; Aristidis Moustakas; Dimitris Kardassis
The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter.
Biochemistry 2002;41(42):12771-84.
2002: Jonas Bondestam; Noora Kaivo-oja; Janne P Kallio; Nigel Groome; Christel Hydén-Granskog; Makiko Fujii; Aristidis Moustakas; Anu Jalanko; Peter ten Dijke; Olli Ritvos
Engagement of activin and bone morphogenetic protein signaling pathway Smad proteins in the induction of inhibin B production in ovarian granulosa cells.
Molecular and cellular endocrinology 2002;195(1-2):79-88.
2002: Ulrich Valcourt; Jérôme Gouttenoire; Aristidis Moustakas; Daniel Herbage; Frédéric Mallein-Gerin
Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes.
The Journal of biological chemistry 2002;277(37):33545-58.
2002: Aristidis Moustakas
Smad signalling network.
Journal of cell science 2002;115(Pt 17):3355-6.
2002: Aristidis Moustakas; Carl-Henrik Heldin
From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction.
Genes & development 2002;16(15):1867-71.
2002: Serhiy Souchelnytskyi; Aristidis Moustakas; Carl-Henrik Heldin
TGF-beta signaling from a three-dimensional perspective: insight into selection of partners.
Trends in cell biology 2002;12(7):304-7.
2002: Aristidis Moustakas; Katerina Pardali; Annamaria Gaal; Carl-Henrik Heldin
Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation.
Immunology letters 2002;82(1-2):85-91.
2001: Aristidis Moustakas; Serhiy Souchelnytskyi; Carl-Henrik Heldin
Smad regulation in TGF-beta signal transduction.
Journal of cell science 2001;114(Pt 24):4359-69.
2001: George Koutsodontis; I Tentes; Paraskevi Papakosta; Aristidis Moustakas; Dimitris Kardassis
Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein.
The Journal of biological chemistry 2001;276(31):29116-25.
2001: Gerard C Blobe; William P Schiemann; Marie-Claude Pepin; M Beauchemin; Aristidis Moustakas; Harvey Lodish; Maureen D O'Connor-McCourt
Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling.
The Journal of biological chemistry 2001;276(27):24627-37.
2001: Akira Kurisaki; S Kose; Y Yoneda; Carl-Henrik Heldin; Aristidis Moustakas
Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner.
Molecular biology of the cell 2001;12(4):1079-91.
2001: Jonas Bondestam; Marko Huotari; Anita Morén; Jarkko Ustinov; Noora Kaivo-oja; Janne P Kallio; Nina Horelli-Kuitunen; Jaakko Aaltonen; M Fujii; Aristidis Moustakas; Peter ten Dijke; Timo Otonkoski; Olli Ritvos
cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C).
Cytogenetics and cell genetics 2001;95(3-4):157-62.
2000: Katerina Pardali; Akira Kurisaki; Anita Morén; Peter ten Dijke; Dimitris Kardassis; Aristidis Moustakas
Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.
The Journal of biological chemistry 2000;275(38):29244-56.
2000: Anita Morén; S Itoh; Aristidis Moustakas; P Dijke; Carl-Henrik Heldin
Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4.
Oncogene 2000;19(38):4396-404.
1999: E Piek; Aristidis Moustakas; Akira Kurisaki; Carl-Henrik Heldin; Peter ten Dijke
TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells.
Journal of cell science 1999;112 ( Pt 24)():4557-68.
1999: Dimitris Kardassis; Paraskevi Papakosta; Katerina Pardali; Aristidis Moustakas
c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1.
The Journal of biological chemistry 1999;274(41):29572-81.
1999: Anna Tsapara; Dimitris Kardassis; Aristidis Moustakas; Achille Gravanis; Christos Stournaras
Expression and characterization of Cys374 mutated human beta-actin in two different mammalian cell lines: impaired microfilament organization and stability.
FEBS letters 1999;455(1-2):117-22.
1999: Aristidis Moustakas; Christos Stournaras
Regulation of actin organisation by TGF-beta in H-ras-transformed fibroblasts.
Journal of cell science 1999;112 ( Pt 8)():1169-79.
1998: Aristidis Moustakas; Dimitris Kardassis
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6733-8.
1998: Aristidis Moustakas; Panayiotis A Theodoropoulos; Achille Gravanis; D Häussinger; Christos Stournaras
The cytoskeleton in cell volume regulation.
Contributions to nephrology 1998;123():121-34.