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Richard Moxon

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TOP 3
Rino Rappuoli; Mariagrazia Pizza; Steven Black; E Richard Moxon
Development of a vaccine against serogroup B has been the main scientific challenge. Preface.
Matthew D Snape; Lisa DeTora; Jonathan Drori; Scott A Halperin; Duccio Medini; E Richard Moxon
The challenge of post-implementation surveillance for novel meningococcal vaccines.
Nicole A Spahich; Derek W Hood; E Richard Moxon; Joseph W St Geme
Inactivation of Haemophilus influenzae lipopolysaccharide biosynthesis genes interferes with outer membrane localization of the hap autotransporter.

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All Publications

2012: Rino Rappuoli; Mariagrazia Pizza; Steven Black; E Richard Moxon
Development of a vaccine against serogroup B has been the main scientific challenge. Preface.
Vaccine 2012;30 Suppl 2():B1-2.
2012: Matthew D Snape; Lisa DeTora; Jonathan Drori; Scott A Halperin; Duccio Medini; E Richard Moxon
The challenge of post-implementation surveillance for novel meningococcal vaccines.
Vaccine 2012;30 Suppl 2():B67-72.
2012: Nicole A Spahich; Derek W Hood; E Richard Moxon; Joseph W St Geme
Inactivation of Haemophilus influenzae lipopolysaccharide biosynthesis genes interferes with outer membrane localization of the hap autotransporter.
Journal of bacteriology 2012;194(7):1815-22.
2012: Peter M Power; Stephen D Bentley; E Richard Moxon; Julian Parkhill; Derek W Hood
Investigations into genome diversity of Haemophilus influenzae using whole genome sequencing of clinical isolates and laboratory transformants.
BMC microbiology 2012;12():273.
2011: E Richard Moxon; Claire-Anne Siegrist
The next decade of vaccines: societal and scientific challenges.
Lancet 2011;378(9788):348-59.
2011: E Richard Moxon; Stanley Plotkin; Pamela Das; Brian Greenwood; David L Heymann; Richard Horton; Orin S Levine; Gus Nossal
A call to action for the new decade of vaccines.
Lancet 2011;378(9788):298-302.
2011: Sonia Budroni; Emilio Siena; Kate L Seib; Davide Serruto; Chiara Nofroni; Maurizio Comanducci; David R Riley; Sean C Daugherty; Samuel V Angiuoli; Antonello Covacci; Mariagrazia Pizza; Rino Rappuoli; E Richard Moxon; Hervé Tettelin; Julie C Hotopp; Duccio Medini
Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(11):4494-9.
2011: E Richard Moxon
Darwin, microbes and evolution by natural selection.
Advances in experimental medicine and biology 2011;697():77-86.
2010: John Donnelly; Duccio Medini; Giuseppe Boccadifuoco; Alessia Biolchi; Joel Ward; Carl Frasch; E Richard Moxon; Maria Stella; Maurizio Comanducci; Stefania Bambini; Alessandro Muzzi; William Andrews; Jie Chen; George Santos; Laura Santini; Philip Boucher; Davide Serruto; Mariagrazia Pizza; Rino Rappuoli; Marzia M Giuliani
Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(45):19490-5.
2010: Andrew D Cox; Frank St Michael; Dhamodharan Neelamegan; Suzanne Lacelle; Chantelle M Cairns; Marzia M Giuliani; Alessia Biolchi; Claire Hoe; E Richard Moxon; James C Richards
Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: immunology of glycoconjugates with high carbohydrate loading.
Glycoconjugate journal 2010;27(7-9):643-8.
2010: Shamez Ladhani; Paul T Heath; Rashna J Aibara; Mary E Ramsay; Mary P E Slack; Martin L Hibberd; Andrew J Pollard; E Richard Moxon; Robert Booy
Long-term complications and risk of other serious infections following invasive Haemophilus influenzae serotype b disease in vaccinated children.
Vaccine 2010;28(10):2195-200.
2010: Claudio Donati; N Luisa Hiller; Hervé Tettelin; Alessandro Muzzi; Nicholas J Croucher; Samuel V Angiuoli; Marco Oggioni; Julie C Hotopp; Fen Ze Hu; David R Riley; Antonello Covacci; Tim Mitchell; Stephen D Bentley; Morgens Kilian; Garth D Ehrlich; Rino Rappuoli; E Richard Moxon; Vega Masignani
Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species.
Genome biology 2010;11(10):R107.
2009: E Richard Moxon
Bacterial variation, virulence and vaccines.
Microbiology (Reading, England) 2009;155(Pt 4):997-1003.
2009: Peter M Power; Wendy A Sweetman; N J Gallacher; M R Woodhall; G A Kumar; E Richard Moxon; Derek W Hood
Simple sequence repeats in Haemophilus influenzae.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2009;9(2):216-28.
2009: Annette Plüddemann; Claire Hoe; Katherine Makepeace; E Richard Moxon; Siamon Gordon
The macrophage scavenger receptor A is host-protective in experimental meningococcal septicaemia.
PLoS pathogens 2009;5(2):e1000297.
2009: Dominic F Kelly; E Richard Moxon; Ly-Mee Yu; Andrew J Pollard
Anti-polyribosylribitol phosphate antibody concentrations and avidities in children since the start of Haemophilus influenzae type b immunization of infants in the United Kingdom.
Clinical and vaccine immunology : CVI 2009;16(2):246-52.
2008: Anne Jäkel; Joyce Plested; Claire Hoe; Katherine Makepeace; Margaret Anne J Gidney; Suzanne Lacelle; Frank St Michael; Andrew D Cox; James C Richards; E Richard Moxon
Naturally-occurring human serum antibodies to inner core lipopolysaccharide epitopes of Neisseria meningitidis protect against invasive meningococcal disease caused by isolates displaying homologous inner core structures.
Vaccine 2008;26(51):6655-63.
2008: Hussein Masoud; E Richard Moxon; Dusan Uhrin; James C Richards
Identification of a novel structural motif in the lipopolysaccharide of the galE/galK double mutant of Haemophilus influenzae strain Eagan.
Carbohydrate research 2008;343(16):2763-70.
2008: Christopher D Bayliss; Claire Hoe; Katherine Makepeace; Patricia Martin; Derek W Hood; E Richard Moxon
Neisseria meningitidis escape from the bactericidal activity of a monoclonal antibody is mediated by phase variation of lgtG and enhanced by a mutator phenotype.
Infection and immunity 2008;76(11):5038-48.
2008: Hussein Masoud; E Richard Moxon; James C Richards
Structural elucidation of the major Hex4 lipopolysaccharide glycoform from the lgtC mutant of Haemophilus influenzae strain Eagan.
Carbohydrate research 2008;343(9):1424-34.
2008: Susanna L Lundström; Jianjun Li; Martin Månsson; Marisol Figueira; Magali Leroy; Richard Goldstein; Derek W Hood; E Richard Moxon; James C Richards; Elke K H Schweda
Application of capillary electrophoresis mass spectrometry and liquid chromatography multiple-step tandem electrospray mass spectrometry to profile glycoform expression during Haemophilus influenzae pathogenesis in the chinchilla model of experimental otitis media.
Infection and immunity 2008;76(7):3255-67.
2008: Susanna L Lundström; Jianjun Li; Mary E Deadman; Derek W Hood; E Richard Moxon; Elke K H Schweda
Structural analysis of the lipopolysaccharide from nontypeable Haemophilus influenzae strain R2846.
Biochemistry 2008;47(22):6025-38.
2008: Monika Dzieciatkowska; Elke K H Schweda; E Richard Moxon; James C Richards; Jianjun Li
Characterization of intact lipopolysaccharides from the Haemophilus influenzae strain RM 118 using electrophoresis-assisted open-tubular liquid chromatography-mass spectrometry.
Electrophoresis 2008;29(10):2171-81.
2008: S Y Oh; David Griffiths; T John; Y C Lee; Ly-Mee Yu; Noel D McCarthy; Paul Heath; Derrick W Crook; M Ramsay; E Richard Moxon; Andrew J Pollard
School-aged children: a reservoir for continued circulation of Haemophilus influenzae type b in the United Kingdom.
The Journal of infectious diseases 2008;197(9):1275-81.
2008: Gaurav A Kumar; Mark R Woodhall; Derek W Hood; E Richard Moxon; Christopher D Bayliss
RecJ, ExoI and RecG are required for genome maintenance but not for generation of genetic diversity by repeat-mediated phase variation in Haemophilus influenzae.
Mutation research 2008;640(1-2):46-53.
2008: Hussein Masoud; E Richard Moxon; James C Richards
Structural elucidation of lipopolysaccharide core oligosaccharides from lic1 and lic1/lic2 mutants of Haemophilus influenzae type b strain Eagan.
Canadian journal of microbiology 2008;54(4):281-90.
2008: E Richard Moxon; Wendy A Sweetman; Mary E Deadman; David J P Ferguson; Derek W Hood
Haemophilus influenzae biofilms: hypothesis or fact?
Trends in microbiology 2008;16(3):95-100.
2008: Kate L Fox; Jianjun Li; Elke K H Schweda; Varvara Vitiazeva; Katherine Makepeace; Michael P Jennings; E Richard Moxon; Derek W Hood
Duplicate copies of lic1 direct the addition of multiple phosphocholine residues in the lipopolysaccharide of Haemophilus influenzae.
Infection and immunity 2008;76(2):588-600.
2007: Susanna L Lundström; Brigitte Twelkmeyer; Malin K Sagemark; Jianjun Li; James C Richards; Derek W Hood; E Richard Moxon; Elke K H Schweda
Novel globoside-like oligosaccharide expression patterns in nontypeable Haemophilus influenzae lipopolysaccharide.
The FEBS journal 2007;274(18):4886-903.
2007: Elke K H Schweda; James C Richards; Derek W Hood; E Richard Moxon
Expression and structural diversity of the lipopolysaccharide of Haemophilus influenzae: implication in virulence.
International journal of medical microbiology : IJMM 2007;297(5):297-306.
2007: Anna Riddell; Jim P Buttery; Jodie McVernon; Tracey Chantler; Laura Lane; Jane Bowen-Morris; Linda Diggle; Rhonwen Morris; Stephen Lockhart; Andrew J Pollard; Keith Cartwright; E Richard Moxon
A randomized study comparing the safety and immunogenicity of a conjugate vaccine combination containing meningococcal group C and pneumococcal capsular polysaccharide--CRM197 with a meningococcal group C conjugate vaccine in healthy infants: challenge phase.
Vaccine 2007;25(19):3906-12.
2007: Tracey Chantler; Amanda Lees; E Richard Moxon; David Mant; Andrew J Pollard; Ray Fiztpatrick
The role familiarity with science and medicine plays in parents' decision making about enrolling a child in vaccine research.
Qualitative health research 2007;17(3):311-22.
2007: Jens U Ruggeberg; Clare Collins; Paul Clarke; Nik Johnson; Ruchi Sinha; Neil Everest; John Chang; Elaine Stanford; Paul Balmer; Ray Borrow; Sarah Martin; Michael J Robinson; E Richard Moxon; Andrew J Pollard; Paul Heath
Immunogenicity and induction of immunological memory of the heptavalent pneumococcal conjugate vaccine in preterm UK infants.
Vaccine 2007;25(2):264-71.
2007: Jianjun Li; Monika Dzieciatkowska; Derek W Hood; Andrew D Cox; Elke K H Schweda; E Richard Moxon; James C Richards
Structural characterization of sialylated glycoforms of H. influenzae by electrospray mass spectrometry: fragmentation of protonated and sodiated O-deacylated lipopolysaccharides.
Rapid communications in mass spectrometry : RCM 2007;21(6):952-60.
2007: Kevin Dixon; Christopher D Bayliss; Katherine Makepeace; E Richard Moxon; Derek W Hood
Identification of the functional initiation codons of a phase-variable gene of Haemophilus influenzae, lic2A, with the potential for differential expression.
Journal of bacteriology 2007;189(2):511-21.
2007: Marisol A Figueira; Sanjay Ram; Richard Goldstein; Derek W Hood; E Richard Moxon; Stephen I Pelton
Role of complement in defense of the middle ear revealed by restoring the virulence of nontypeable Haemophilus influenzae siaB mutants.
Infection and immunity 2007;75(1):325-33.
2006: Kate L Fox; Andrew D Cox; Michel Gilbert; Warren W Wakarchuk; Jianjun Li; Katherine Makepeace; James C Richards; E Richard Moxon; Derek W Hood
Identification of a bifunctional lipopolysaccharide sialyltransferase in Haemophilus influenzae: incorporation of disialic acid.
The Journal of biological chemistry 2006;281(52):40024-32.
2006: Matthew D Snape; Dominic F Kelly; Penny Salt; Sarah Green; Claire Snowden; Linda Diggle; Astrid Borkowski; Ly-Mee Yu; E Richard Moxon; Andrew J Pollard
Serogroup C meningococcal glycoconjugate vaccine in adolescents: persistence of bactericidal antibodies and kinetics of the immune response to a booster vaccine more than 3 years after immunization.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;43(11):1387-94.
2006: Dominic F Kelly; Matthew D Snape; Elizabeth A Clutterbuck; Elizabeth A Cutterbuck; Sarah Green; Claire Snowden; Linda Diggle; Ly-Mee Yu; Astrid Borkowski; E Richard Moxon; Andrew J Pollard
CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cells.
Blood 2006;108(8):2642-7.
2006: Mary E Deadman; Susanna L Lundström; Elke K H Schweda; E Richard Moxon; Derek W Hood
Specific amino acids of the glycosyltransferase LpsA direct the addition of glucose or galactose to the terminal inner core heptose of Haemophilus influenzae lipopolysaccharide via alternative linkages.
The Journal of biological chemistry 2006;281(40):29455-67.
2006: Leanne Peiser; Katherine Makepeace; Annette Plüddemann; Silvana Savino; Claire Hoe; Mariagrazia Pizza; Rino Rappuoli; E Richard Moxon; Siamon Gordon
Identification of Neisseria meningitidis nonlipopolysaccharide ligands for class A macrophage scavenger receptor by using a novel assay.
Infection and immunity 2006;74(9):5191-9.
2006: Karen L Sleeman; David Griffiths; Fiona Shackley; Linda Diggle; Sunetra Gupta; Martin C J Maiden; E Richard Moxon; Derrick W Crook; T E A Peto
Capsular serotype-specific attack rates and duration of carriage of Streptococcus pneumoniae in a population of children.
The Journal of infectious diseases 2006;194(5):682-8.
2006: Christopher D Bayliss; Martin Callaghan; E Richard Moxon
High allelic diversity in the methyltransferase gene of a phase variable type III restriction-modification system has implications for the fitness of Haemophilus influenzae.
Nucleic acids research 2006;34(14):4046-59.
2005: Dominic F Kelly; Andrew J Pollard; E Richard Moxon
Immunological memory: the role of B cells in long-term protection against invasive bacterial pathogens.
JAMA : the journal of the American Medical Association 2005;294(23):3019-23.
2005: Håkan Yildirim; Jianjun Li; James C Richards; Derek W Hood; E Richard Moxon; Elke K H Schweda
Complex O-acetylation in non-typeable Haemophilus influenzae lipopolysaccharide: evidence for a novel site of O-acetylation.
Carbohydrate research 2005;340(17):2598-611.
2005: E Richard Moxon; Vincent A A Jansen
Phage variation: understanding the behaviour of an accidental pathogen.
Trends in microbiology 2005;13(12):563-5.
2005: Clare L Collins; Jens U Ruggeberg; Gail Balfour; Helen Tighe; Marion Archer; Jane Bowen-Morris; Linda Diggle; Ray Borrow; Paul Balmer; Jim P Buttery; E Richard Moxon; Andrew J Pollard; Paul Heath
Immunogenicity and immunologic memory of meningococcal C conjugate vaccine in premature infants.
The Pediatric infectious disease journal 2005;24(11):966-8.
2005: Andrew D Cox; Wei Zou; Margaret Anne J Gidney; Suzanne Lacelle; Joyce Plested; Katherine Makepeace; Claire Hoe; Philip A Coull; E Richard Moxon; James C Richards
Candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: developmental chemistry and investigation of immunological responses following immunization of mice and rabbits.
Vaccine 2005;23(43):5045-54.
2005: Ruth Griffin; Christopher D Bayliss; Mark A Herbert; Andrew D Cox; Katherine Makepeace; James C Richards; Derek W Hood; E Richard Moxon
Digalactoside expression in the lipopolysaccharide of Haemophilus influenzae and its role in intravascular survival.
Infection and immunity 2005;73(10):7022-6.
2005: Kate L Fox; Håkan Yildirim; Mary E Deadman; Elke K H Schweda; E Richard Moxon; Derek W Hood
Novel lipopolysaccharide biosynthetic genes containing tetranucleotide repeats in Haemophilus influenzae, identification of a gene for adding O-acetyl groups.
Molecular microbiology 2005;58(1):207-16.
2005: Wendy A Sweetman; E Richard Moxon; Christopher D Bayliss
Induction of the SOS regulon of Haemophilus influenzae does not affect phase variation rates at tetranucleotide or dinucleotide repeats.
Microbiology (Reading, England) 2005;151(Pt 8):2751-63.
2005: Jianjun Li; Andrew D Cox; Derek W Hood; Elke K H Schweda; E Richard Moxon; James C Richards
Electrophoretic and mass spectrometric strategies for profiling bacterial lipopolysaccharides.
Molecular bioSystems 2005;1(1):46-52.
2005: Jim P Buttery; Anna Riddell; Jodie McVernon; Tracey Chantler; Laura Lane; Jane Bowen-Morris; Linda Diggle; Rhonwen Morris; Anthony Harnden; Stephen Lockhart; Andrew J Pollard; Keith Cartwright; E Richard Moxon
Immunogenicity and safety of a combination pneumococcal-meningococcal vaccine in infants: a randomized controlled trial.
JAMA : the journal of the American Medical Association 2005;293(14):1751-8.
2005: Håkan Yildirim; Jianjun Li; James C Richards; Derek W Hood; E Richard Moxon; Elke K H Schweda
An alternate pattern for globoside oligosaccharide expression in Haemophilus influenzae lipopolysaccharide: structural diversity in nontypeable strain 1124.
Biochemistry 2005;44(13):5207-24.
2005: Ruth Griffin; Andrew D Cox; Katherine Makepeace; James C Richards; E Richard Moxon; Derek W Hood
Elucidation of the monoclonal antibody 5G8-reactive, virulence-associated lipopolysaccharide epitope of Haemophilus influenzae and its role in bacterial resistance to complement-mediated killing.
Infection and immunity 2005;73(4):2213-21.
2005: Patricia Martin; Katherine Makepeace; Stuart A Hill; Derek W Hood; E Richard Moxon
Microsatellite instability regulates transcription factor binding and gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3800-4.
2005: Matthew D Snape; Dominic F Kelly; Ben Green; E Richard Moxon; Ray Borrow; Andrew J Pollard
Lack of serum bactericidal activity in preschool children two years after a single dose of serogroup C meningococcal polysaccharide-protein conjugate vaccine.
The Pediatric infectious disease journal 2005;24(2):128-31.
2005: Karen L Sleeman; Lesley Daniels; Marion Gardiner; David Griffiths; Jonathan J Deeks; Ron Dagan; Sunetra Gupta; E Richard Moxon; T E A Peto; Derrick W Crook
Acquisition of Streptococcus pneumoniae and nonspecific morbidity in infants and their families: a cohort study.
The Pediatric infectious disease journal 2005;24(2):121-7.
2005: Jianjun Li; Adele Martin; Andrew D Cox; E Richard Moxon; James C Richards; Pierre Thibault
Mapping bacterial glycolipid complexity using capillary electrophoresis and electrospray mass spectrometry.
Methods in enzymology 2005;405():369-97.
2005: Christopher D Bayliss; Wendy A Sweetman; E Richard Moxon
Destabilization of tetranucleotide repeats in Haemophilus influenzae mutants lacking RnaseHI or the Klenow domain of PolI.
Nucleic acids research 2005;33(1):400-8.
2004: Derek W Hood; Gaynor A Randle; Andrew D Cox; Katherine Makepeace; Jianjun Li; Elke K H Schweda; James C Richards; E Richard Moxon
Biosynthesis of cryptic lipopolysaccharide glycoforms in Haemophilus influenzae involves a mechanism similar to that required for O-antigen synthesis.
Journal of bacteriology 2004;186(21):7429-39.
2004: C L Collins; Penny Salt; N McCarthy; Tracey Chantler; Laura Lane; Fabienne Hemme; Linda Diggle; Jim P Buttery; N R E Kitchin; E Richard Moxon; Andrew J Pollard
Immunogenicity and safety of a low-dose diphtheria, tetanus and acellular pertussis combination vaccine with either inactivated or oral polio vaccine as a pre-school booster in UK children.
Vaccine 2004;22(31-32):4262-9.
2004: Claire Hoe; Derek W Hood; Gaynor A Randle; Katherine Makepeace; Andrew D Cox; Jianjun Li; Ronald Chalmers; James C Richards; E Richard Moxon
lpt6, a gene required for addition of phosphoethanolamine to inner-core lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae.
Journal of bacteriology 2004;186(20):6970-82.
2004: Dominic F Kelly; E Richard Moxon; Andrew J Pollard
Haemophilus influenzae type b conjugate vaccines.
Immunology 2004;113(2):163-74.
2004: Patricia Martin; Li Sun; Derek W Hood; E Richard Moxon
Involvement of genes of genome maintenance in the regulation of phase variation frequencies in Neisseria meningitidis.
Microbiology (Reading, England) 2004;150(Pt 9):3001-12.
2004: Keith Jolley; Li Sun; E Richard Moxon; Martin C J Maiden
Dam inactivation in Neisseria meningitidis: prevalence among diverse hyperinvasive lineages.
BMC microbiology 2004;4():34.
2004: Derek W Hood; Mary E Deadman; Andrew D Cox; Katherine Makepeace; Adele Martin; James C Richards; E Richard Moxon
Three genes, lgtF, lic2C and lpsA, have a primary role in determining the pattern of oligosaccharide extension from the inner core of Haemophilus influenzae LPS.
Microbiology (Reading, England) 2004;150(Pt 7):2089-97.
2004: Jianjun Li; Andrew D Cox; Derek Hood; E Richard Moxon; James C Richards
Application of capillary electrophoresis- electrospray-mass spectrometry to the separation and characterization of isomeric lipopolysaccharides of Neisseria meningitidis.
Electrophoresis 2004;25(13):2017-25.
2004: Christopher D Bayliss; Wendy A Sweetman; E Richard Moxon
Mutations in Haemophilus influenzae mismatch repair genes increase mutation rates of dinucleotide repeat tracts but not dinucleotide repeat-driven pilin phase variation rates.
Journal of bacteriology 2004;186(10):2928-35.
2004: Malin K Landerholm; Jianjun Li; James C Richards; Derek W Hood; E Richard Moxon; Elke K H Schweda
Characterization of novel structural features in the lipopolysaccharide of nondisease associated nontypeable Haemophilus influenzae.
European journal of biochemistry / FEBS 2004;271(5):941-53.
2004: Christopher D Bayliss; Kevin M Dixon; E Richard Moxon
Simple sequence repeats (microsatellites): mutational mechanisms and contributions to bacterial pathogenesis. A meeting review.
FEMS immunology and medical microbiology 2004;40(1):11-9.
2004: Dominic Kelly; E Richard Moxon
Is Haemophilus influenzae type b disease finished?
Advances in experimental medicine and biology 2004;549():221-9.
2004: Dawn Field; Jennifer Hughes; E Richard Moxon
Using the genome to understand pathogenicity.
Methods in molecular biology (Clifton, N.J.) 2004;266():261-87.
2004: Jodie McVernon; N Avrion Mitchison; E Richard Moxon
T helper cells and efficacy of Haemophilus influenzae type b conjugate vaccination.
The Lancet infectious diseases 2004;4(1):40-3.
2004: Margaret Anne J Gidney; Joyce Plested; Suzanne Lacelle; Philip A Coull; Claire Hoe; Katherine Makepeace; Jean-Robert Brisson; Andrew D Cox; E Richard Moxon; James C Richards
Development, characterization, and functional activity of a panel of specific monoclonal antibodies to inner core lipopolysaccharide epitopes in Neisseria meningitidis.
Infection and immunity 2004;72(1):559-69.
2003: Sanjay Ram; Andrew D Cox; Claire Hoe; Ulrich Vogel; Silke Getzlaff; Ryan Boden; Jianjun Li; Joyce Plested; Seppo Meri; Sunita Gulati; Daniel C. Stein; James C Richards; E Richard Moxon; Peter A Rice
Neisserial lipooligosaccharide is a target for complement component C4b. Inner core phosphoethanolamine residues define C4b linkage specificity.
The Journal of biological chemistry 2003;278(51):50853-62.
2003: Ruth Griffin; Andrew D Cox; Katherine Makepeace; James C Richards; E Richard Moxon; Derek W Hood
The role of lex2 in lipopolysaccharide biosynthesis in Haemophilus influenzae strains RM7004 and RM153.
Microbiology (Reading, England) 2003;149(Pt 11):3165-75.
2003: Patricia Martin; Tamsin van de Ven; N Mouchel; Alex Jeffries; Derek W Hood; E Richard Moxon
Experimentally revised repertoire of putative contingency loci in Neisseria meningitidis strain MC58: evidence for a novel mechanism of phase variation.
Molecular microbiology 2003;50(1):245-57.
2003: Håkan Yildirim; Derek W Hood; E Richard Moxon; Elke K H Schweda
Structural analysis of lipopolysaccharides from Haemophilus influenzae serotype f. Structural diversity observed in three strains.
European journal of biochemistry / FEBS 2003;270(15):3153-67.
2003: Valérie Bouchet; Derek W Hood; Jianjun Li; Jean-Robert Brisson; Gaynor A Randle; Adèle Martin; Zhong Li; Richard Goldstein; Elke K H Schweda; Stephen I Pelton; James C Richards; E Richard Moxon
Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8898-903.
2003: Jodie McVernon; Jenny Maclennan; Andrew J Pollard; Philipp Oster; Mark J Wakefield; Lisa Danzig; E Richard Moxon
Immunologic memory with no detectable bactericidal antibody response to a first dose of meningococcal serogroup C conjugate vaccine at four years.
The Pediatric infectious disease journal 2003;22(7):659-61.
2003: Martin Månsson; Derek W Hood; E Richard Moxon; Elke K H Schweda
Structural characterization of a novel branching pattern in the lipopolysaccharide from nontypeable Haemophilus influenzae.
European journal of biochemistry / FEBS 2003;270(14):2979-91.
2003: Jodie McVernon; Jenny Maclennan; Elizabeth Clutterbuck; Jim P Buttery; E Richard Moxon
Effect of infant immunisation with meningococcus serogroup C-CRM(197) conjugate vaccine on diphtheria immunity and reactogenicity in pre-school aged children.
Vaccine 2003;21(19-20):2573-9.
2003: Andrew D Cox; Claire Hoe; Jianjun Li; Derek W Hood; E Richard Moxon; James C Richards
Phosphorylation of the lipid A region of meningococcal lipopolysaccharide: identification of a family of transferases that add phosphoethanolamine to lipopolysaccharide.
Journal of bacteriology 2003;185(11):3270-7.
2003: Alison J Cody; Dawn Field; Edward J Feil; Suzanna Stringer; Mary E Deadman; Anthony G Tsolaki; Brett Gratz; Valérie Bouchet; Richard Goldstein; Derek W Hood; E Richard Moxon
High rates of recombination in otitis media isolates of non-typeable Haemophilus influenzae.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2003;3(1):57-66.
2003: Jodie McVernon; Paul Johnson; Andrew J Pollard; M P E Slack; E Richard Moxon
Immunologic memory in Haemophilus influenzae type b conjugate vaccine failure.
Archives of disease in childhood 2003;88(5):379-83.
2003: Hussein Masoud; Adèle Martin; Pierre Thibault; E Richard Moxon; James C Richards
Structure of extended lipopolysaccharide glycoforms containing two globotriose units in Haemophilus influenzae serotype b strain RM7004.
Biochemistry 2003;42(15):4463-75.
2003: Joyce Plested; Shannon L Harris; Claire Hoe; Philip A Coull; Katherine Makepeace; Margaret Anne J Gidney; Jean-Robert Brisson; James C Richards; Dan M Granoff; E Richard Moxon
Highly conserved Neisseria meningitidis inner-core lipopolysaccharide epitope confers protection against experimental meningococcal bacteremia.
The Journal of infectious diseases 2003;187(8):1223-34.
2003: Andrew D Cox; Claire Hoe; Margaret Anne J Gidney; Suzanne Lacelle; Joyce Plested; Adele Martin; E Richard Moxon; James C Richards
Identification of a novel inner-core oligosaccharide structure in Neisseria meningitidis lipopolysaccharide.
European journal of biochemistry / FEBS 2003;270(8):1759-66.
2003: Paul Heath; Robert Booy; Jodie McVernon; Jane Bowen-Morris; H Griffiths; M P E Slack; AC Moloney; Mary E Ramsay; E Richard Moxon
Hib vaccination in infants born prematurely.
Archives of disease in childhood 2003;88(3):206-10.
2003: Nigel J Saunders; E Richard Moxon; Mike B Gravenor
Mutation rates: estimating phase variation rates when fitness differences are present and their impact on population structure.
Microbiology (Reading, England) 2003;149(Pt 2):485-95.
2003: Martin Månsson; Derek W Hood; E Richard Moxon; Elke K H Schweda
Structural diversity in lipopolysaccharide expression in nontypeable Haemophilus influenzae. Identification of L-glycerol-D-manno-heptose in the outer-core region in three clinical isolates.
European journal of biochemistry / FEBS 2003;270(4):610-24.
2002: Mark A Herbert; S Hayes; Mary E Deadman; C M Tang; Derek W Hood; E Richard Moxon
Signature Tagged Mutagenesis of Haemophilus influenzae identifies genes required for in vivo survival.
Microbial pathogenesis 2002;33(5):211-23.
2002: Leanne Peiser; Menno de Winther; Katherine Makepeace; Michael Hollinshead; Philip A Coull; Joyce Plested; Tatsuhiko Kodama; E Richard Moxon; Siamon Gordon
The class A macrophage scavenger receptor is a major pattern recognition receptor for Neisseria meningitidis which is independent of lipopolysaccharide and not required for secretory responses.
Infection and immunity 2002;70(10):5346-54.
2002: Andrew D Cox; Jianjun Li; Jean-Robert Brisson; E Richard Moxon; James C Richards
Structural analysis of the lipopolysaccharide from Neisseria meningitidis strain BZ157 galE: localisation of two phosphoethanolamine residues in the inner core oligosaccharide.
Carbohydrate research 2002;337(16):1435-44.
2002: Jodie McVernon; Jenny Maclennan; Jim P Buttery; Philipp Oster; Lisa Danzig; E Richard Moxon
Safety and immunogenicity of meningococcus serogroup C conjugate vaccine administered as a primary or booster vaccination to healthy four-year-old children.
The Pediatric infectious disease journal 2002;21(8):747-53.
2002: Andrew D Cox; Derek W Hood; Adele Martin; Katherine Makepeace; Mary E Deadman; Jianjun Li; Jean-Robert Brisson; E Richard Moxon; James C Richards
Identification and structural characterization of a sialylated lacto-N-neotetraose structure in the lipopolysaccharide of Haemophilus influenzae.
European journal of biochemistry / FEBS 2002;269(16):4009-19.
2002: Andrew J Pollard; E Richard Moxon
The meningococcus tamed?
Archives of disease in childhood 2002;87(1):13-7.
2002: Christopher D Bayliss; Tamsin van de Ven; E Richard Moxon
Mutations in polI but not mutSLH destabilize Haemophilus influenzae tetranucleotide repeats.
The EMBO journal 2002;21(6):1465-76.
2002: Elke K H Schweda; Jianjun Li; E Richard Moxon; James C Richards
Structural analysis of lipopolysaccharide oligosaccharide epitopes expressed by non-typeable Haemophilus influenzae strain 176.
Carbohydrate research 2002;337(5):409-20.
2002: Christoph M Tang; Dave Stroud; Fiona G Mackinnon; Katherine Makepeace; Joyce Plested; E Richard Moxon; Ronald Chalmers
Genetic linkage analysis to identify a gene required for the addition of phosphoethanolamine to meningococcal lipopolysaccharide.
Gene 2002;284(1-2):133-40.
2002: Fiona G Mackinnon; Andrew D Cox; Joyce Plested; Christoph M Tang; Katherine Makepeace; Philip A Coull; Claire Hoe; Ronald Chalmers; Derek W Hood; James C Richards; E Richard Moxon
Identification of a gene (lpt-3) required for the addition of phosphoethanolamine to the lipopolysaccharide inner core of Neisseria meningitidis and its role in mediating susceptibility to bactericidal killing and opsonophagocytosis.
Molecular microbiology 2002;43(4):931-43.
2002: Martin Månsson; Derek W Hood; Jianjun Li; James C Richards; E Richard Moxon; Elke K H Schweda
Structural analysis of the lipopolysaccharide from nontypeable Haemophilus influenzae strain 1003.
European journal of biochemistry / FEBS 2002;269(3):808-18.
2002: E Richard Moxon; Derek W Hood; Nigel J Saunders; Elke K H Schweda; J C Richards
Functional genomics of pathogenic bacteria.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2002;357(1417):109-16.
2002: Jim P Buttery; E Richard Moxon
Capsulate bacteria and the lung.
British medical bulletin 2002;61():63-80.
2001: Jianjun Li; SH Bauer; Martin Månsson; E Richard Moxon; James C Richards; Elke K H Schweda
Glycine is a common substituent of the inner core in Haemophilus influenzae lipopolysaccharide.
Glycobiology 2001;11(12):1009-15.
2001: Derek W Hood; Andrew D Cox; Warren W Wakarchuk; Melissa J Schur; Elke K H Schweda; S L Walsh; Mary E Deadman; Adele Martin; E Richard Moxon; James C Richards
Genetic basis for expression of the major globotetraose-containing lipopolysaccharide from H. influenzae strain Rd (RM118).
Glycobiology 2001;11(11):957-67.
2001: SH Bauer; Martin Månsson; Derek W Hood; James C Richards; E Richard Moxon; Elke K H Schweda
A rapid and sensitive procedure for determination of 5-N-acetyl neuraminic acid in lipopolysaccharides of Haemophilus influenzae: a survey of 24 non-typeable H. influenzae strains.
Carbohydrate research 2001;335(4):251-60.
2001: Joyce Plested; B L Ferry; Philip A Coull; Katherine Makepeace; A K Lehmann; Fiona G Mackinnon; H G Griffiths; Mark A Herbert; James C Richards; E Richard Moxon
Functional opsonic activity of human serum antibodies to inner core lipopolysaccharide (galE) of serogroup B meningococci measured by flow cytometry.
Infection and immunity 2001;69(5):3203-13.
2001: Martin Månsson; SH Bauer; Derek W Hood; James C Richards; E Richard Moxon; Elke K H Schweda
A new structural type for Haemophilus influenzae lipopolysaccharide. Structural analysis of the lipopolysaccharide from nontypeable Haemophilus influenzae strain 486.
European journal of biochemistry / FEBS 2001;268(7):2148-59.
2001: Paul Heath; Robert Booy; HJ Azzopardi; M P E Slack; J Fogarty; AC Moloney; Mary E Ramsay; E Richard Moxon
Non-type b Haemophilus influenzae disease: clinical and epidemiologic characteristics in the Haemophilus influenzae type b vaccine era.
The Pediatric infectious disease journal 2001;20(3):300-5.
2001: Christopher D Bayliss; Dawn Field; E Richard Moxon
The simple sequence contingency loci of Haemophilus influenzae and Neisseria meningitidis.
The Journal of clinical investigation 2001;107(6):657-62.
2001: Karen L Sleeman; Kyle Knox; R George; Elizabeth Miller; Pauline Waight; David Griffiths; Androulla Efstratiou; K Broughton; Richard Mayon-White; E Richard Moxon; Derrick W Crook
Invasive pneumococcal disease in England and Wales: vaccination implications.
The Journal of infectious diseases 2001;183(2):239-246.
2001: James C Richards; Andrew D Cox; Elke K H Schweda; Adele Martin; Derek W Hood; E Richard Moxon
Structure and functional genomics of lipopolysaccharide expression in Haemophilus influenzae.
Advances in experimental medicine and biology 2001;491():515-24.
2001: Derek W Hood; Andrew D Cox; M Gilbert; Katherine Makepeace; S Walsh; Mary E Deadman; Alison J Cody; Adele Martin; Martin Månsson; Elke K H Schweda; Jean-Robert Brisson; James C Richards; E Richard Moxon; Warren W Wakarchuk
Identification of a lipopolysaccharide alpha-2,3-sialyltransferase from Haemophilus influenzae.
Molecular microbiology 2001;39(2):341-50.
2001: Jenny Maclennan; Stephen Obaro; J Deeks; D Lake; C Elie; G Carlone; E Richard Moxon; B Greenwood
Immunologic memory 5 years after meningococcal A/C conjugate vaccination in infancy.
The Journal of infectious diseases 2001;183(1):97-104.
2000: Mike English; Jenny Maclennan; Jane Bowen-Morris; J Deeks; M Boardman; K Brown; S Smith; Jim P Buttery; J Clarke; S Quataert; Stephen Lockhart; E Richard Moxon
A randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants.
Vaccine 2000;19(9-10):1232-8.
2000: Paul Heath; Robert Booy; HJ Azzopardi; M P E Slack; Jane Bowen-Morris; H Griffiths; Mary E Ramsay; J J Deeks; E Richard Moxon
Antibody concentration and clinical protection after Hib conjugate vaccination in the United Kingdom.
JAMA : the journal of the American Medical Association 2000;284(18):2334-40.
2000: Christopher D Bayliss; Dawn Field; Xavier De Bolle; E Richard Moxon
The generation of diversity by Haemophilus influenzae: response.
Trends in microbiology 2000;8(10):435-6.
2000: Paul Heath; Robert Booy; H Griffiths; E Clutterbuck; HJ Azzopardi; M P E Slack; J Fogarty; AC Moloney; E Richard Moxon
Clinical and immunological risk factors associated with Haemophilus influenzae type b conjugate vaccine failure in childhood.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000;31(4):973-80.
2000: J Martindale; Dave Stroud; E Richard Moxon; Christoph M Tang
Genetic analysis of Escherichia coli K1 gastrointestinal colonization.
Molecular microbiology 2000;37(6):1293-305.
2000: Fiona Shackley; K Knox; J B Morris; Derrick W Crook; David Griffiths; Richard Mayon-White; R George; L Willocks; E Richard Moxon
Outcome of invasive pneumococcal disease: a UK based study. Oxford Pneumococcal Surveillance Group.
Archives of disease in childhood 2000;83(3):231-3.
2000: Nigel J Saunders; Alex Jeffries; John F Peden; Derek W Hood; Hervé Tettelin; R Rappuoli; E Richard Moxon
Repeat-associated phase variable genes in the complete genome sequence of Neisseria meningitidis strain MC58.
Molecular microbiology 2000;37(1):207-15.
2000: JM MacLennan; Fiona Shackley; Paul Heath; J J Deeks; C Flamank; M Herbert; H Griffiths; E Hatzmann; C Goilav; E Richard Moxon
Safety, immunogenicity, and induction of immunologic memory by a serogroup C meningococcal conjugate vaccine in infants: A randomized controlled trial.
JAMA : the journal of the American Medical Association 2000;283(21):2795-801.
2000: Jim P Buttery; E Richard Moxon
Varicella vaccine in renal failure.
Lancet 2000;355(9219):1930.
2000: Nigel J Saunders; Alex Jeffries; Derek W Hood; E Richard Moxon
High rates of phase variation in Campylobacter jejuni?
Molecular microbiology 2000;36(6):1504.
2000: Elke K H Schweda; Jean-Robert Brisson; G Alvelius; A Martin; J N Weiser; Derek W Hood; E Richard Moxon; James C Richards
Characterization of the phosphocholine-substituted oligosaccharide in lipopolysaccharides of type b Haemophilus influenzae.
European journal of biochemistry / FEBS 2000;267(12):3902-13.
2000: Joyce Plested; Margaret Anne J Gidney; Philip A Coull; H G Griffiths; Mark A Herbert; A G Bird; James C Richards; E Richard Moxon
Enzyme linked immunosorbent assay (ELISA) for the detection of serum antibodies to the inner core lipopolysaccharide of Neisseria meningitidis group B.
Journal of immunological methods 2000;237(1-2):73-84.
2000: J P Buttery; E Richard Moxon
Designing meningitis vaccines.
Journal of the Royal College of Physicians of London 2000;34(2):163-8.
2000: Xavier De Bolle; Christopher D Bayliss; Dawn Field; Tamsin van de Ven; Nigel J Saunders; Derek W Hood; E Richard Moxon
The length of a tetranucleotide repeat tract in Haemophilus influenzae determines the phase variation rate of a gene with homology to type III DNA methyltransferases.
Molecular microbiology 2000;35(1):211-22.
1999: Nigel J Saunders; John F Peden; E Richard Moxon
Absence in Helicobacter pylori of an uptake sequence for enhancing uptake of homospecific DNA during transformation.
Microbiology (Reading, England) 1999;145 ( Pt 12)():3523-8.
1999: E Richard Moxon; Paul Heath; Robert Booy; HJ Azzopardi; M P E Slack; Mary E Ramsay
4th European conference on vaccinology: societal value of vaccination. The impact of Hib conjugate vaccines in preventing invasive H. influenzae diseases in the UK.
Vaccine 1999;17 Suppl 3():S11-3.
1999: Joyce Plested; Katherine Makepeace; M P Jennings; Margaret Anne J Gidney; Suzanne Lacelle; J Brisson; Andrew D Cox; Adele Martin; A G Bird; Christoph M Tang; F M Mackinnon; James C Richards; E Richard Moxon
Conservation and accessibility of an inner core lipopolysaccharide epitope of Neisseria meningitidis.
Infection and immunity 1999;67(10):5417-26.
1999: Derek W Hood; James C Richards; E Richard Moxon
Haemophilus influenzae lipopolysaccharide.
Biochemical Society transactions 1999;27(4):493-8.
1999: Derek W Hood; Katherine Makepeace; Mary E Deadman; R F Rest; Pierre Thibault; Adele Martin; James C Richards; E Richard Moxon
Sialic acid in the lipopolysaccharide of Haemophilus influenzae: strain distribution, influence on serum resistance and structural characterization.
Molecular microbiology 1999;33(4):679-92.
1999: F Bell; P Health; Fiona Shackley; JM MacLennan; M Herbert; N Shearstone; Linda Diggle; E Richard Moxon; Adam Finn
Poor response to hib (PRP-T) vaccine when combined with an acellular pertussis/diphtheria/tetanus vaccine for primary immunization of infants.
Biologicals : journal of the International Association of Biological Standardization 1999;27(2):113.
1999: F Bell; P Heath; JM MacLennan; Fiona Shackley; N Shearstone; Linda Diggle; C Thornton; H Griffiths; E Richard Moxon; Adam Finn
Adverse effects and sero-responses to an acellular pertussis/diphtheria/tetanus vaccine when combined with Haemophilus influenzae type b vaccine in an accelerated schedule.
European journal of pediatrics 1999;158(4):329-36.
1999: A Risberg; Hussein Masoud; Adele Martin; James C Richards; E Richard Moxon; Elke K H Schweda
Structural analysis of the lipopolysaccharide oligosaccharide epitopes expressed by a capsule-deficient strain of Haemophilus influenzae Rd.
European journal of biochemistry / FEBS 1999;261(1):171-80.
1999: Nigel J Saunders; Derek W Hood; E Richard Moxon
Bacterial evolution: bacteria play pass the gene.
Current biology : CB 1999;9(5):R180-3.
1999: E Richard Moxon; C Wills
DNA microsatellites: agents of evolution?
Scientific American 1999;280(1):94-9.
1998: S L Hosking; M E Deadman; E Richard Moxon; John F Peden; Nigel J Saunders; Nicola J High
An in silico evaluation of Tn916 as a tool for generalized mutagenesis in Haemophilus influenzae Rd.
Microbiology (Reading, England) 1998;144 ( Pt 9)():2525-30.
1998: F Bell; P Heath; Fiona Shackley; JM MacLennan; N Shearstone; Linda Diggle; H Griffiths; E Richard Moxon; Adam Finn
Effect of combination with an acellular pertussis, diphtheria, tetanus vaccine on antibody response to Hib vaccine (PRP-T).
Vaccine 1998;16(6):637-42.
1998: Nigel J Saunders; John F Peden; Derek W Hood; E Richard Moxon
Simple sequence repeats in the Helicobacter pylori genome.
Molecular microbiology 1998;27(6):1091-8.
1998: C M Tang; Derek W Hood; E Richard Moxon
Microbial genome sequencing and pathogenesis.
Current opinion in microbiology 1998;1(1):12-6.
1998: E Richard Moxon
Natural history and pathogenesis as they affect clinical trials.
Developments in biological standardization 1998;95():61-7.
1998: E Richard Moxon; Derek Hood; J Richards
Bacterial lipopolysaccharides: candidate vaccines to prevent Neisseria meningitidis and Haemophilus influenzae infections.
Advances in experimental medicine and biology 1998;435():237-43.
1997: Paul Heath; Jane Bowen-Morris; D Griffiths; H Griffiths; Derrick W Crook; E Richard Moxon
Antibody persistence and Haemophilus influenzae type b carriage after infant immunisation with PRP-T.
Archives of disease in childhood 1997;77(6):488-92.
1997: Paul Heath; Robert Booy; M P E Slack; E Richard Moxon; J Fogarty
Are Hib booster vaccinations redundant?
Lancet 1997;350(9080):817.
1997: Hussein Masoud; E Richard Moxon; Adele Martin; D Krajcarski; James C Richards
Structure of the variable and conserved lipopolysaccharide oligosaccharide epitopes expressed by Haemophilus influenzae serotype b strain Eagan.
Biochemistry 1997;36(8):2091-103.