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Lennart Mucke

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Meaghan Morris; Anthony Adame; Nino Devidze; Patricia Hamto; Eliezer Masliah; Lennart Mucke
Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice.
Elsa Suberbielle; Xin Wang; Pascal E Sanchez; Nino Devidze; Kirsten Eilertson; Kaitlyn Ho; Alexxai V Kravitz; Anatol C Kreitzer; Lennart Mucke
Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β.
Pascal E Sanchez; Laure Verret; Keith A Vossel; Gui-Qiu Yu; Lei Zhu; John R Cirrito; Nino Devidze; Kaitlyn Ho; Anna G Orr; Jorge J Palop; Lennart Mucke
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.

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All Publications

2013: Meaghan Morris; Anthony Adame; Nino Devidze; Patricia Hamto; Eliezer Masliah; Lennart Mucke
Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice.
Neurobiology of aging 2013;34(6):1523-9.
2013: Elsa Suberbielle; Xin Wang; Pascal E Sanchez; Nino Devidze; Kirsten Eilertson; Kaitlyn Ho; Alexxai V Kravitz; Anatol C Kreitzer; Lennart Mucke
Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β.
Nature neuroscience 2013;16(5):613-21.
2012: Pascal E Sanchez; Laure Verret; Keith A Vossel; Gui-Qiu Yu; Lei Zhu; John R Cirrito; Nino Devidze; Kaitlyn Ho; Anna G Orr; Jorge J Palop; Lennart Mucke
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(42):E2895-903.
2012: Lennart Mucke; Dennis J Selkoe
Neurotoxicity of amyloid β-protein: synaptic and network dysfunction.
Cold Spring Harbor perspectives in medicine 2012;2(7):a006338.
2012: Laure Verret; Albert M I Barth; Inma Cobos; Nino Devidze; Giao B Hang; Kaitlyn Ho; Anatol C Kreitzer; Edward O Mann; Eliezer Masliah; Istvan Mody; Lennart Mucke; Jorge J Palop
Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.
Cell 2012;149(3):708-21.
2012: Yadong Huang; Lennart Mucke
Alzheimer mechanisms and therapeutic strategies.
Cell 2012;148(6):1204-22.
2012: Julie A Harris; Kaitlyn Ho; Akihiko Koyama; Sumihiro Maeda; Eliezer Masliah; Nino Devidze; Dena B Dubal; Gui-Qiu Yu; Lennart Mucke
Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
PloS one 2012;7(9):e45881.
2012: S Sakura Minami; Lennart Mucke; Mike Pleiss; Ketul Popat; Binggui Sun; Michael E Ward; Yungui Zhou; Tejal Desai; Paul Floreancig; Tiina Kauppinen; Li Gan
Selective targeting of microglia by quantum dots.
Journal of neuroinflammation 2012;9():22.
2011: Moustapha Cissé; Kaitlyn Ho; Daniel H Kim; Pascal E Sanchez; Gui-Qiu Yu; Lennart Mucke
Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(29):10427-31.
2011: Meaghan Morris; Sumihiro Maeda; Keith Vossel; Lennart Mucke
The many faces of tau.
Neuron 2011;70(3):410-26.
2011: Erik Roberson; Brian Halabisky; Jong W Yoo; Jinghua Yao; Jeannie Chin; Fengrong Yan; Tiffany Wu; Patricia Hamto; Nino Devidze; Gui-Qiu Yu; Jorge J Palop; Jeffrey L Noebels; Lennart Mucke
Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(2):700-11.
2011: Moustapha Cissé; Brian Halabisky; Julie Harris; Nino Devidze; Dena B Dubal; Binggui Sun; Anna Orr; Gregor Lotz; Daniel H Kim; Patricia Hamto; Kaitlyn Ho; Gui-Qiu Yu; Lennart Mucke
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.
Nature 2011;469(7328):47-52.
2011: Jorge J Palop; Lennart Mucke; Erik D Roberson
Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins and inhibitory hippocampal remodeling.
Methods in molecular biology (Clifton, N.J.) 2011;670():245-62.
2010: Julie A Harris; Nino Devidze; Laure Verret; Kaitlyn Ho; Brian Halabisky; Myo T Thwin; Daniel Kim; Patricia Hamto; Iris Lo; Gui-Qiu Yu; Jorge J Palop; Eliezer Masliah; Lennart Mucke
Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.
Neuron 2010;68(3):428-41.
2010: Keith A Vossel; Kai Zhang; Jens Brodbeck; Aaron C Daub; Punita Sharma; Steven Finkbeiner; Bianxiao Cui; Lennart Mucke
Tau reduction prevents Abeta-induced defects in axonal transport.
Science (New York, N.Y.) 2010;330(6001):198.
2010: Manuel Buttini; Eliezer Masliah; Gui-Qiu Yu; Jorge J Palop; Shengjun Chang; Aubrey Bernardo; Carol Lin; Tony Wyss-Coray; Yadong Huang; Lennart Mucke
Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice.
The American journal of pathology 2010;177(2):563-9.
2010: Rene O Sanchez-Mejia; Lennart Mucke
Phospholipase A2 and arachidonic acid in Alzheimer's disease.
Biochimica et biophysica acta 2010;1801(8):784-90.
2010: Jorge J Palop; Lennart Mucke
Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks.
Nature neuroscience 2010;13(7):812-8.
2010: Jorge J Palop; Lennart Mucke
Synaptic depression and aberrant excitatory network activity in Alzheimer's disease: two faces of the same coin?
Neuromolecular medicine 2010;12(1):48-55.
2010: Julie A Harris; Nino Devidze; Brian Halabisky; Iris Lo; Myo T Thwin; Gui-Qiu Yu; Dale E Bredesen; Eliezer Masliah; Lennart Mucke
Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(1):372-81.
2009: Binggui Sun; Brian Halabisky; Yungui Zhou; Jorge J Palop; Guiqiu Yu; Lennart Mucke; Li Gan
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.
Cell stem cell 2009;5(6):624-33.
2009: Lennart Mucke
Neuroscience: Alzheimer's disease.
Nature 2009;461(7266):895-7.
2009: Jorge J Palop; Lennart Mucke
Epilepsy and cognitive impairments in Alzheimer disease.
Archives of neurology 2009;66(4):435-40.
2009: ZAVEN KHACHATURIAN; Peter J Snyder; Rachelle S Doody; Paul S Aisen; Meryl Comer; John Dwyer; Richard A Frank; Andrew Holzapfel; Ara Khachaturian; Amos D Korczyn; Allen D Roses; James W Simpkins; Lon S Schneider; Marilyn S Albert; Robert Egge; Aaron Deves; Steven Ferris; Barry D Greenberg; Carl Johnson; Walter A Kukull; Judes Poirier; Dale Schenk; William Thies; S Gauthier; Sid Gilman; Charles Bernick; Jeffrey L Cummings; Howard Fillit; Michael Grundman; Jeffrey A Kaye; Lennart Mucke; Barry Reisberg; Mary Sano; Oxana Pickeral; Ronald C. Petersen; Richard C Mohs; Maria Carrillo; Jody Corey-Bloom; Norman L Foster; Steve Jacobsen; Virginia M-Y Lee; William Z Potter; Marwan Sabbagh; David P Salmon; John Q Trojanowski; Nancy Wexler; Lisa J Bain
A roadmap for the prevention of dementia II: Leon Thal Symposium 2008.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2009;5(2):85-92.
2009: Moustapha Cisse; Lennart Mucke
Alzheimer's disease: A prion protein connection.
Nature 2009;457(7233):1090-1.
2009: William J Meilandt; Moustapha Cisse; Kaitlyn Ho; Tiffany Wu; Luke A Esposito; Kimberly Scearce-Levie; Irene H Cheng; Gui-Qiu Yu; Lennart Mucke
Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(7):1977-86.
2009: Jason S Cheng; Dena B Dubal; Daniel H Kim; Justin Legleiter; Irene H Cheng; Gui-Qiu Yu; Ina C. Tesseur; Tony Wyss-Coray; Paolo Bonaldo; Lennart Mucke
Collagen VI protects neurons against Abeta toxicity.
Nature neuroscience 2009;12(2):119-21.
2008: Rene O Sanchez-Mejia; John William Newman; Sandy Toh; Gui-Qiu Yu; Yungui Zhou; Brian Halabisky; Moustapha Cissé; Kimberly Scearce-Levie; Irene H Cheng; Li Gan; Jorge J Palop; Joseph V Bonventre; Lennart Mucke
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.
Nature neuroscience 2008;11(11):1311-8.
2008: Gültekin Tamgüney; Kurt Giles; David V Glidden; Pierre Lessard; Holger Wille; Patrick Tremblay; Darlene F Groth; Fruma Yehiely; Carsten Korth; Richard C Moore; Jörg Tatzelt; Eric Rubinstein; Claude Boucheix; Xiaoping Yang; Pamela Stanley; Michael P Lisanti; Raymond A Dwek; Pauline M Rudd; Jackob Moskovitz; Charles J Epstein; Tracey Dawson Cruz; William Kuziel; Nobuyo Maeda; Jan Sap; Karen K. Hsiao Ashe; George A Carlson; Ina C. Tesseur; Tony Wyss-Coray; Lennart Mucke; Karl H Weisgraber; Robert W Mahley; Fred Cohen; Stanley B Prusiner
Genes contributing to prion pathogenesis.
The Journal of general virology 2008;89(Pt 7):1777-88.
2008: William J Meilandt; Gui-Qiu Yu; Jeannie Chin; Erik Roberson; Jorge J Palop; Tiffany Wu; Kimberly Scearce-Levie; Lennart Mucke
Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(19):5007-17.
2008: Li Gan; Lennart Mucke
Paths of convergence: sirtuins in aging and neurodegeneration.
Neuron 2008;58(1):10-4.
2008: Kimberly Scearce-Levie; Erik Roberson; Hilary Gerstein; J A Cholfin; V S Mandiyan; N M Shah; J L R Rubenstein; Lennart Mucke
Abnormal social behaviors in mice lacking Fgf17.
Genes, brain, and behavior 2008;7(3):344-54.
2008: Amy R Deipolyi; Shanna Fang; Jorge J Palop; Gui-Qiu Yu; Xin Wang; Lennart Mucke
Altered navigational strategy use and visuospatial deficits in hAPP transgenic mice.
Neurobiology of aging 2008;29(2):253-66.
2007: Jorge J Palop; Jeannie Chin; Erik Roberson; Jun Wang; Myo T Thwin; Nga Bien-Ly; Jong Yoo; Kaitlyn O Ho; Gui-Qiu Yu; Anatol Kreitzer; Steven Finkbeiner; Jeffrey L Noebels; Lennart Mucke
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Neuron 2007;55(5):697-711.
2007: Amy R Deipolyi; Katherine P Rankin; Lennart Mucke; Bruce L Miller; Maria Luisa Gorno-Tempini
Spatial cognition and the human navigation network in AD and MCI.
Neurology 2007;69(10):986-97.
2007: Irene H Cheng; Kimberly Scearce-Levie; Justin Legleiter; Jorge J Palop; Hilary Gerstein; Nga Bien-Ly; Jukka Puoliväli; Sylvain Lesné; Karen K. Hsiao Ashe; Paul J Muchowski; Lennart Mucke
Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.
The Journal of biological chemistry 2007;282(33):23818-28.
2007: Erik Roberson; Kimberly Scearce-Levie; Jorge J Palop; Fengrong Yan; Irene H Cheng; Tiffany Wu; Hilary Gerstein; Gui-Qiu Yu; Lennart Mucke
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
Science (New York, N.Y.) 2007;316(5825):750-4.
2007: Jeannie Chin; Catherine Massaro; Jorge J Palop; Myo T Thwin; Gui-Qiu Yu; Nga Bien-Ly; Aaron Bender; Lennart Mucke
Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(11):2727-33.
2006: Erik Roberson; Lennart Mucke
100 years and counting: prospects for defeating Alzheimer's disease.
Science (New York, N.Y.) 2006;314(5800):781-4.
2006: Ina C. Tesseur; Kun Zou; Luke Esposito; Frédérique Bard; Elisabeth Berber; Judith Van Can; Amy H Lin; Leslie Crews; Patrick Tremblay; Paul Mathews; Lennart Mucke; Eliezer Masliah; Tony Wyss-Coray
Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology.
The Journal of clinical investigation 2006;116(11):3060-9.
2006: Jorge J Palop; Jeannie Chin; Lennart Mucke
A network dysfunction perspective on neurodegenerative diseases.
Nature 2006;443(7113):768-73.
2006: Sarah Mueller-Steiner; Yungui Zhou; Hideaki Arai; Erik Roberson; Binggui Sun; Jennifer Chen; Xin Wang; Guiqiu Yu; Luke Esposito; Lennart Mucke; Li Gan
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.
Neuron 2006;51(6):703-14.
2006: Doo-Sup Choi; Dan Wang; Gui-Qiu Yu; Guofen Zhu; Viktor Kharazia; J Peter Paredes; Wesley S Chang; Jason K Deitchman; Lennart Mucke; Robert O Messing
PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(21):8215-20.
2006: Luke Esposito; Jacob Raber; Lisa Kekonius; Fengrong Yan; Gui-Qiu Yu; Nga Bien-Ly; Jukka Puoliväli; Kimberly Scearce-Levie; Eliezer Masliah; Lennart Mucke
Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(19):5167-79.
2006: Richard Morris; Lennart Mucke
Alzheimer's disease: A needle from the haystack.
Nature 2006;440(7082):284-5.
2005: Jennifer Chen; Yungui Zhou; Sarah Mueller-Steiner; Lin Feng Chen; Hakju Kwon; Saili Yi; Lennart Mucke; Li Gan
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
The Journal of biological chemistry 2005;280(48):40364-74.
2005: Jeannie Chin; Jorge J Palop; Jukka Puoliväli; Catherine Massaro; Nga Bien-Ly; Hilary Gerstein; Kimberly Scearce-Levie; Eliezer Masliah; Lennart Mucke
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(42):9694-703.
2005: Jorge J Palop; Jeannie Chin; Nga Bien-Ly; Catherine Massaro; Bertrand Z Yeung; Gui-Qiu Yu; Lennart Mucke
Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(42):9686-93.
2005: Edward Rockenstein; Michael Mante; Michael Alford; Anthony Adame; Leslie Crews; Makoto Hashimoto; Luke Esposito; Lennart Mucke; Eliezer Masliah
High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease.
The Journal of biological chemistry 2005;280(38):32957-67.
2004: Luke Esposito; Li Gan; Gui-Qiu Yu; Christian Essrich; Lennart Mucke
Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
Journal of neurochemistry 2004;91(6):1260-74.
2004: Irene H Cheng; Jorge J Palop; Luke Esposito; Nga Bien-Ly; Fengrong Yan; Lennart Mucke
Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation.
Nature medicine 2004;10(11):1190-2.
2004: Ottavio Arancio; Hui Ping Zhang; Xi Chen; Chang Lin; Fabrizio Trinchese; Lucia Privitera; Shumin Liu; Ashok Hegde; Shi Fang Yan; Alan Stern; John S Luddy; Lih-Fen Lue; Douglas G. Walker; Alex Roher; Manuel Buttini; Lennart Mucke; Weiying Li; Ann Marie Schmidt; Mark S Kindy; Paul A Hyslop; David M Stern; Shi Du Yan
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice.
The EMBO journal 2004;23(20):4096-105.
2004: Lennart Mucke; Robert E Pitas
Food for thought: essential fatty acid protects against neuronal deficits in transgenic mouse model of AD.
Neuron 2004;43(5):596-9.
2004: Jeannie Chin; Jorge J Palop; Gui-Qiu Yu; Nobuhiko Kojima; Eliezer Masliah; Lennart Mucke
Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(19):4692-7.
2004: Walter J Brecht; Faith M Harris; Shengjun Chang; Ina C. Tesseur; Gui-Qiu Yu; Qin Xu; Jo Dee Fish; Tony Wyss-Coray; Manuel Buttini; Lennart Mucke; Robert W Mahley; Yadong Huang
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(10):2527-34.
2004: Yadong Huang; Karl H Weisgraber; Lennart Mucke; Robert W Mahley
Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.
Journal of molecular neuroscience : MN 2004;23(3):189-204.
2003: Faith M Harris; Walter J Brecht; Qin Xu; Ina C. Tesseur; Lisa Kekonius; Tony Wyss-Coray; Jo Dee Fish; Eliezer Masliah; Paul C Hopkins; Kimberly Scearce-Levie; Karl H Weisgraber; Lennart Mucke; Robert W Mahley; Yadong Huang
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10966-71.
2003: Jorge J Palop; Brian Jones; Lisa Kekonius; Jeannie Chin; Gui-Qiu Yu; Jacob Raber; Eliezer Masliah; Lennart Mucke
Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9572-7.
2002: Manuel Buttini; Gui-Qiu Yu; Kristina Shockley; Yadong Huang; Brian Jones; Eliezer Masliah; Margaret Mallory; Tracy Yeo; Frank M Longo; Lennart Mucke
Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(24):10539-48.
2002: Tony Wyss-Coray; Lennart Mucke
Inflammation in neurodegenerative disease--a double-edged sword.
Neuron 2002;35(3):419-32.
2002: Jacob Raber; Gerold Bongers; Anthony LeFevour; Manuel Buttini; Lennart Mucke
Androgens protect against apolipoprotein E4-induced cognitive deficits.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(12):5204-9.
2001: Eliezer Masliah; Edward Rockenstein; isaac veinbergs; Yutaka Sagara; Margaret Mallory; Makoto Hashimoto; Lennart Mucke
beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12245-50.
2001: Tony Wyss-Coray; C Lin; Fengrong Yan; Gui-Qiu Yu; M Rohde; Lisa McConlogue; Eliezer Masliah; Lennart Mucke
TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.
Nature medicine 2001;7(5):612-8.
2000: Lennart Mucke; Gui-Qiu Yu; Lisa McConlogue; Edward Rockenstein; Carmela Abraham; Eliezer Masliah
Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice.
The American journal of pathology 2000;157(6):2003-10.
2000: Tony Wyss-Coray; Lennart Mucke
Ibuprofen, inflammation and Alzheimer disease.
Nature medicine 2000;6(9):973-4.
2000: Lennart Mucke; Eliezer Masliah; Gui-Qiu Yu; Margaret Mallory; Edward Rockenstein; G Tatsuno; Kang Hu; Dora Kholodenko; Kelly Johnson-Wood; Lisa McConlogue
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(11):4050-8.
2000: Tony Wyss-Coray; C Lin; Dominique Von Euw; Eliezer Masliah; Lennart Mucke; Pierre Lacombe
Alzheimer's disease-like cerebrovascular pathology in transforming growth factor-beta 1 transgenic mice and functional metabolic correlates.
Annals of the New York Academy of Sciences 2000;903():317-23.
2000: Jacob Raber; D Wong; Gui-Qiu Yu; Manuel Buttini; Robert W Mahley; Robert E Pitas; Lennart Mucke
Apolipoprotein E and cognitive performance.
Nature 2000;404(6776):352-4.
2000: Jacob Raber; Susan F Akana; Seema Bhatnagar; Mary F Dallman; D Wong; Lennart Mucke
Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterations.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(5):2064-71.
2000: Eliezer Masliah; Edward Rockenstein; isaac veinbergs; Margaret Mallory; Makoto Hashimoto; A Takeda; Yutaka Sagara; Abbyann Sisk; Lennart Mucke
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders.
Science (New York, N.Y.) 2000;287(5456):1265-9.
2000: Manuel Buttini; H Akeefe; Chang Lin; Robert W Mahley; Robert E Pitas; Tony Wyss-Coray; Lennart Mucke
Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease.
Neuroscience 2000;97(2):207-10.
2000: Tony Wyss-Coray; C Lin; David A Sanan; Lennart Mucke; Eliezer Masliah
Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice.
The American journal of pathology 2000;156(1):139-50.
1999: Rudi D'Hooge; Frieda Franck; Lennart Mucke; Peter Paul De Deyn
Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120.
The European journal of neuroscience 1999;11(12):4398-402.
1999: F Huang; Manuel Buttini; Tony Wyss-Coray; Lisa McConlogue; T Kodama; Robert E Pitas; Lennart Mucke
Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors.
The American journal of pathology 1999;155(5):1741-7.
1999: Michael V Sofroniew; Toby G Bush; N Blumauer; Lennart Mucke; Martin H Johnson
Genetically-targeted and conditionally-regulated ablation of astroglial cells in the central, enteric and peripheral nervous systems in adult transgenic mice.
Brain research 1999;835(1):91-5.
1999: X Xu; Dun Yang; Tony Wyss-Coray; J Yan; L Gan; Y Sun; Lennart Mucke
Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(13):7547-52.
1999: Manuel Buttini; Matthias Orth; Stefano Bellosta; H Akeefe; Robert E Pitas; Tony Wyss-Coray; Lennart Mucke; Robert W Mahley
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(12):4867-80.
1999: Toby G Bush; N Puvanachandra; C H Horner; Bella Polito; Thor Ostenfeld; Clive Svendsen; Lennart Mucke; Martin H Johnson; Michael V Sofroniew
Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice.
Neuron 1999;23(2):297-308.
1999: A Y Hsia; Eliezer Masliah; Lisa McConlogue; Gui-Qiu Yu; G Tatsuno; Kang Hu; Dora Kholodenko; Robert C Malenka; Roger A Nicoll; Lennart Mucke
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3228-33.
1998: Jacob Raber; D Wong; Manuel Buttini; Matthias Orth; Stefano Bellosta; Robert E Pitas; Robert W Mahley; Lennart Mucke
Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10914-9.
1998: Eliezer Masliah; Jacob Raber; Michael Alford; Margaret Mallory; Mark P Mattson; D Yang; D Wong; Lennart Mucke
Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis.
The Journal of biological chemistry 1998;273(20):12548-54.
1998: Toby G Bush; Tor C Savidge; Tom C Freeman; H J Cox; Elizabeth A Campbell; Lennart Mucke; Martin H Johnson; Michael V Sofroniew
Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice.
Cell 1998;93(2):189-201.
1998: Manuel Buttini; C E Westland; Eliezer Masliah; A M Yafeh; Tony Wyss-Coray; Lennart Mucke
Novel role of human CD4 molecule identified in neurodegeneration.
Nature medicine 1998;4(4):441-6.
1998: Thomas Krucker; S M Toggas; Lennart Mucke; George R Siggins
Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in CA1 hippocampus.
Neuroscience 1998;83(3):691-700.
1997: X Xu; Jacob Raber; Dun Yang; B Su; Lennart Mucke
Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12655-60.
1997: Alex J Raeber; Richard E Race; Sebastian Brandner; Suzette A Priola; A Sailer; RA Bessen; Lennart Mucke; J Manson; Adriano Aguzzi; M B Oldstone; Charles Weissmann; Bruce Chesebro
Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.
The EMBO journal 1997;16(20):6057-65.
1997: Tony Wyss-Coray; Eliezer Masliah; Margaret Mallory; Lisa McConlogue; Kelly Johnson-Wood; C Lin; Lennart Mucke
Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease.
Nature 1997;389(6651):603-6.
1997: Tony Wyss-Coray; P Borrow; M J Brooker; Lennart Mucke
Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice .
Journal of neuroimmunology 1997;77(1):45-50.
1997: Jacob Raber; Shizhong Chen; Lennart Mucke; L Feng
Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effects.
The Journal of biological chemistry 1997;272(24):15057-60.
1997: Eliezer Masliah; C E Westland; Edward Rockenstein; Carmela Abraham; Margaret Mallory; I Veinberg; E Sheldon; Lennart Mucke
Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo.
Neuroscience 1997;78(1):135-46.
1997: Mark P Mattson; Steven W Barger; K Furukawa; AJ Bruce; Tony Wyss-Coray; RJ Mark; Lennart Mucke
Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease.
Brain research. Brain research reviews 1997;23(1-2):47-61.
1996: Jacob Raber; S M Toggas; S Lee; F E Bloom; C J Epstein; Lennart Mucke
Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.
Virology 1996;226(2):362-73.
1996: J Zhao; L Paganini; Lennart Mucke; M Gordon; L Refolo; M Carman; Sukanto Sinha; Tilman Oltersdorf; I Lieberburg; Lisa McConlogue
Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes.
The Journal of biological chemistry 1996;271(49):31407-11.
1996: Rudi D'Hooge; Guy Nagels; C E Westland; Lennart Mucke; Peter Paul De Deyn
Spatial learning deficit in mice expressing human 751-amino acid beta-amyloid precursor protein.
Neuroreport 1996;7(15-17):2807-11.
1996: Eliezer Masliah; Abbyann Sisk; Margaret Mallory; Lennart Mucke; Dale Schenk; Dora Games
Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(18):5795-811.
1996: M H Mohajeri; U Bartsch; Herman van der Putten; Gilles Sansig; Lennart Mucke; M Schachner
Neurite outgrowth on non-permissive substrates in vitro is enhanced by ectopic expression of the neural adhesion molecule L1 by mouse astrocytes.
The European journal of neuroscience 1996;8(6):1085-97.
1996: Tony Wyss-Coray; Eliezer Masliah; S M Toggas; Edward Rockenstein; M J Brooker; H S Lee; Lennart Mucke
Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis.
The Journal of clinical investigation 1996;97(3):789-98.
1996: Lennart Mucke; Carmela Abraham; Eliezer Masliah
Neurotrophic and neuroprotective effects of hAPP in transgenic mice.
Annals of the New York Academy of Sciences 1996;777():82-8.
1996: S M Toggas; Eliezer Masliah; Lennart Mucke
Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.
Brain research 1996;706(2):303-7.
1996: Eliezer Masliah; N Ge; Lennart Mucke
Pathogenesis of HIV-1 associated neurodegeneration.
Critical reviews in neurobiology 1996;10(1):57-67.
1996: S M Toggas; Lennart Mucke
Transgenic models in the study of AIDS dementia complex.
Current topics in microbiology and immunology 1996;206():223-41.
1995: Edward Rockenstein; Lisa McConlogue; H Tan; M Power; Eliezer Masliah; Lennart Mucke
Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease.
The Journal of biological chemistry 1995;270(47):28257-67.
1995: G F Rall; Lennart Mucke; Michael B A Oldstone
Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo.
The Journal of experimental medicine 1995;182(5):1201-12.
1995: Richard E Race; Suzette A Priola; RA Bessen; D Ernst; J Dockter; G F Rall; Lennart Mucke; Bruce Chesebro; Michael B A Oldstone
Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent.
Neuron 1995;15(5):1183-91.
1995: Persephone Borrow; J L Cornell; M D Ruppe; Lennart Mucke
Immunization-induced inflammatory infiltration of the central nervous system in transgenic mice expressing a microbial antigen in astrocytes.
Journal of neuroimmunology 1995;61(2):133-49.
1995: Tony Wyss-Coray; Lili Feng; Eliezer Masliah; M D Ruppe; H S Lee; S M Toggas; Edward Rockenstein; Lennart Mucke
Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1.
The American journal of pathology 1995;147(1):53-67.
1995: L Verderber; W Johnson; Lennart Mucke; V Sarthy
Differential regulation of a glial fibrillary acidic protein-LacZ transgene in retinal astrocytes and Müller cells.
Investigative ophthalmology & visual science 1995;36(6):1137-43.
1995: Lennart Mucke; Carmela Abraham; M D Ruppe; Edward Rockenstein; S M Toggas; Margaret Mallory; Michael Alford; Eliezer Masliah
Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein.
The Journal of experimental medicine 1995;181(4):1551-6.
1995: S A Lipton; Douglas E Brenneman; Faye S Silverstein; Eliezer Masliah; Lennart Mucke
gp120 and neurotoxicity in vivo.
Trends in pharmacological sciences 1995;16(4):122.
1995: W B Johnson; M D Ruppe; Edward Rockenstein; J Price; V P Sarthy; L C Verderber; Lennart Mucke
Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes.
Glia 1995;13(3):174-84.
1995: Lennart Mucke; Eliezer Masliah; I L Campbell
Transgenic models to assess the neuropathogenic potential of HIV-1 proteins and cytokines.
Current topics in microbiology and immunology 1995;202():187-205.
1994: Lennart Mucke; Eliezer Masliah; W B Johnson; M D Ruppe; Michael Alford; Edward Rockenstein; S Forss-Petter; M Pietropaolo; Margaret Mallory; Carmela Abraham
Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice.
Brain research 1994;666(2):151-67.
1994: G F Rall; Lennart Mucke; M Nerenberg; Michael B A Oldstone
A transgenic mouse model to assess the interaction of cytotoxic T lymphocytes with virally infected, class I MHC-expressing astrocytes.
Journal of neuroimmunology 1994;52(1):61-8.
1994: S M Toggas; Eliezer Masliah; Edward Rockenstein; G F Rall; Carmela Abraham; Lennart Mucke
Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.
Nature 1994;367(6459):188-93.
1993: Iain L Campbell; Carmela Abraham; Eliezer Masliah; P Kemper; J D Inglis; Michael B A Oldstone; Lennart Mucke
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10061-5.
1993: Lennart Mucke; M Eddleston
Astrocytes in infectious and immune-mediated diseases of the central nervous system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(13):1226-32.
1993: Carmela Abraham; K Kanemaru; Lennart Mucke
Expression of cathepsin G-like and alpha 1-antichymotrypsin-like proteins in reactive astrocytes.
Brain research 1993;621(2):222-32.
1993: M Eddleston; Lennart Mucke
Molecular profile of reactive astrocytes--implications for their role in neurologic disease.
Neuroscience 1993;54(1):15-36.
1992: Carmela Abraham; B L Razzaboni; G Papastoitsis; E Picard; K Kanemaru; B Meckelein; Lennart Mucke
Purification and cloning of brain proteases capable of degrading the beta-amyloid precursor protein.
Annals of the New York Academy of Sciences 1992;674():174-9.
1992: Lennart Mucke; Michael B A Oldstone
The expression of major histocompatibility complex (MHC) class I antigens in the brain differs markedly in acute and persistent infections with lymphocytic choriomeningitis virus (LCMV).
Journal of neuroimmunology 1992;36(2-3):193-8.
1991: E Joly; Lennart Mucke; M B Oldstone
Viral persistence in neurons explained by lack of major histocompatibility class I expression.
Science (New York, N.Y.) 1991;253(5025):1283-5.
1991: Lennart Mucke; M B Oldstone; J C Morris; M I Nerenberg
Rapid activation of astrocyte-specific expression of GFAP-lacZ transgene by focal injury.
The New biologist 1991;3(5):465-74.
1990: M E Ross; M J Evinger; Steven E Hyman; J M Carroll; Lennart Mucke; Michael J Comb; D J Reis; Tong H Joh; Howard M Goodman
Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(2):520-30.
1988: J R Berger; Lennart Mucke
Prolonged survival and partial recovery in AIDS-associated progressive multifocal leukoencephalopathy.
Neurology 1988;38(7):1060-5.
1988: G Benedek; Lennart Mucke; Masao Norita; B Albowitz; O D Creutzfeldt
Anterior ectosylvian visual area (AEV) of the cat: physiological properties.
Progress in brain research 1988;75():245-55.
1987: Martin Schalling; A Dagerlind; S Brene; R Petterson; S Kvist; M Brownstein; S E Hyman; Lennart Mucke; H M Goodman; T H Joh
Localization of mRNA for phenylethanolamine N-methyltransferase (PNMT) using in situ hybridization.
Acta physiologica Scandinavica 1987;131(4):631-2.
1987: Lennart Mucke; R Maciewicz
Clinical management of neuropathic pain.
Neurologic clinics 1987;5(4):649-63.
1986: Masao Norita; Lennart Mucke; G Benedek; B Albowitz; Y Katoh; O D Creutzfeldt
Connections of the anterior ectosylvian visual area (AEV).
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1986;62(2):225-40.
1982: Lennart Mucke; Masao Norita; G Benedek; O Creutzfeldt
Physiologic and anatomic investigation of a visual cortical area situated in the ventral bank of the anterior ectosylvian sulcus of the cat.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1982;46(1):1-11.