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Mike Mueckler

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Mike Mueckler; Bernard Thorens
The SLC2 (GLUT) family of membrane transporters.
Mike Mueckler; Carol Makepeace
Ligand-induced movements of inner transmembrane helices of Glut1 revealed by chemical cross-linking of di-cysteine mutants.
Arturo Alisio; Mike Mueckler
Purification and characterization of mammalian glucose transporters expressed in Pichia pastoris.

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All Publications

2013: Mike Mueckler; Bernard Thorens
The SLC2 (GLUT) family of membrane transporters.
Molecular aspects of medicine 2013;34(2-3):121-38.
2012: Mike Mueckler; Carol Makepeace
Ligand-induced movements of inner transmembrane helices of Glut1 revealed by chemical cross-linking of di-cysteine mutants.
PloS one 2012;7(2):e31412.
2010: Arturo Alisio; Mike Mueckler
Purification and characterization of mammalian glucose transporters expressed in Pichia pastoris.
Protein expression and purification 2010;70(1):81-7.
2010: Bernard Thorens; Mike Mueckler
Glucose transporters in the 21st Century.
American journal of physiology. Endocrinology and metabolism 2010;298(2):E141-5.
2009: Mike Mueckler; Carol Makepeace
Model of the exofacial substrate-binding site and helical folding of the human Glut1 glucose transporter based on scanning mutagenesis.
Biochemistry 2009;48(25):5934-42.
2008: Xiao Mei Song; Richard C Hresko; Mike Mueckler
Identification of amino acid residues within the C terminus of the Glut4 glucose transporter that are essential for insulin-stimulated redistribution to the plasma membrane.
The Journal of biological chemistry 2008;283(18):12571-85.
2008: Mike Mueckler; Carol Makepeace
Transmembrane segment 6 of the Glut1 glucose transporter is an outer helix and contains amino acid side chains essential for transport activity.
The Journal of biological chemistry 2008;283(17):11550-5.
2006: Mike Mueckler; Carol Makepeace
Transmembrane segment 12 of the Glut1 glucose transporter is an outer helix and is not directly involved in the transport mechanism.
The Journal of biological chemistry 2006;281(48):36993-8.
2005: Richard C Hresko; Mike Mueckler
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.
The Journal of biological chemistry 2005;280(49):40406-16.
2005: Mike Mueckler; Carol Makepeace
Cysteine-scanning mutagenesis and substituted cysteine accessibility analysis of transmembrane segment 4 of the Glut1 glucose transporter.
The Journal of biological chemistry 2005;280(47):39562-8.
2004: Mike Mueckler; William Roach; Carol Makepeace
Transmembrane segment 3 of the Glut1 glucose transporter is an outer helix.
The Journal of biological chemistry 2004;279(45):46876-81.
2004: Arturo Alisio; Mike Mueckler
Relative proximity and orientation of helices 4 and 8 of the GLUT1 glucose transporter.
The Journal of biological chemistry 2004;279(25):26540-5.
2004: Mike Mueckler; Carol Makepeace
Analysis of transmembrane segment 8 of the GLUT1 glucose transporter by cysteine-scanning mutagenesis and substituted cysteine accessibility.
The Journal of biological chemistry 2004;279(11):10494-9.
2003: Abdullah A Osman; Mitsuyoshi Saito; Carol Makepeace; M Alan Permutt; Paul H Schlesinger; Mike Mueckler
Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium.
The Journal of biological chemistry 2003;278(52):52755-62.
2003: Haruhiko Murata; Richard C Hresko; Mike Mueckler
Reconstitution of phosphoinositide 3-kinase-dependent insulin signaling in a cell-free system.
The Journal of biological chemistry 2003;278(24):21607-14.
2003: Richard C Hresko; Haruhiko Murata; Mike Mueckler
Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes.
The Journal of biological chemistry 2003;278(24):21615-22.
2002: Maria G Buse; Katherine A Robinson; Bess A Marshall; Richard C Hresko; Mike Mueckler
Enhanced O-GlcNAc protein modification is associated with insulin resistance in GLUT1-overexpressing muscles.
American journal of physiology. Endocrinology and metabolism 2002;283(2):E241-50.
2002: Richard C Hresko; Mike Mueckler
Identification of pp68 as the Tyrosine-phosphorylated Form of SYNCRIP/NSAP1. A cytoplasmic RNA-binding protein.
The Journal of biological chemistry 2002;277(28):25233-8.
2002: Haruhiko Murata; Paul W Hruz; Mike Mueckler
Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations.
AIDS (London, England) 2002;16(6):859-63.
2002: Paul W Hruz; Haruhiko Murata; Haijun Qiu; Mike Mueckler
Indinavir induces acute and reversible peripheral insulin resistance in rats.
Diabetes 2002;51(4):937-42.
2002: Hans-Georg Joost; Graeme I Bell; James D Best; Morris J Birnbaum; Maureen J Charron; Y T Chen; Holger Doege; David E James; Harvey Lodish; Kelle H Moley; Jeffrey F Moley; Mike Mueckler; Suzanne Rogers; Annette Schürmann; Susumu Seino; Bernard Thorens
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.
American journal of physiology. Endocrinology and metabolism 2002;282(4):E974-6.
2002: Haruhiko Murata; Paul W Hruz; Mike Mueckler
Investigating the cellular targets of HIV protease inhibitors: implications for metabolic disorders and improvements in drug therapy.
Current drug targets. Infectious disorders 2002;2(1):1-8.
2002: Mike Mueckler; Carol Makepeace
Analysis of transmembrane segment 10 of the Glut1 glucose transporter by cysteine-scanning mutagenesis and substituted cysteine accessibility.
The Journal of biological chemistry 2002;277(5):3498-503.
2001: Paul W Hruz; Mike Mueckler
Structural analysis of the GLUT1 facilitative glucose transporter (review).
Molecular membrane biology 2001;18(3):183-93.
2001: Mike Mueckler
Insulin resistance and the disruption of Glut4 trafficking in skeletal muscle.
The Journal of clinical investigation 2001;107(10):1211-3.
2001: Paul W Hruz; Haruhiko Murata; Mike Mueckler
Adverse metabolic consequences of HIV protease inhibitor therapy: the search for a central mechanism.
American journal of physiology. Endocrinology and metabolism 2001;280(4):E549-53.
2000: Paul W Hruz; Mike Mueckler
Cysteine-scanning mutagenesis of transmembrane segment 11 of the GLUT1 facilitative glucose transporter.
Biochemistry 2000;39(31):9367-72.
2000: Polly A Hansen; BA Marshall; M Chen; John O Holloszy; Mike Mueckler
Transgenic overexpression of hexokinase II in skeletal muscle does not increase glucose disposal in wild-type or Glut1-overexpressing mice.
The Journal of biological chemistry 2000;275(29):22381-6.
2000: Haruhiko Murata; Paul W Hruz; Mike Mueckler
The mechanism of insulin resistance caused by HIV protease inhibitor therapy.
The Journal of biological chemistry 2000;275(27):20251-4.
2000: Mary O Carayannopoulos; Maggie M-Y Chi; Y Cui; J M Pingsterhaus; Robert A McKnight; Mike Mueckler; Sherin U Devaskar; Kelle H Moley
GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7313-8.
2000: Richard C Hresko; Mike Mueckler
A novel 68-kDa adipocyte protein phosphorylated on tyrosine in response to insulin and osmotic shock.
The Journal of biological chemistry 2000;275(24):18114-20.
2000: Kelle H Moley; Mike Mueckler
Glucose transport and apoptosis.
Apoptosis : an international journal on programmed cell death 2000;5(2):99-105.
2000: Jian Ming Ren; N Barucci; Bess A Marshall; P Hansen; Mike Mueckler; Gerald I Shulman
Transgenic mice overexpressing GLUT-1 protein in muscle exhibit increased muscle glycogenesis after exercise.
American journal of physiology. Endocrinology and metabolism 2000;278(4):E588-92.
1999: Paul W Hruz; Mike Mueckler
Cysteine-scanning mutagenesis of transmembrane segment 7 of the GLUT1 glucose transporter.
The Journal of biological chemistry 1999;274(51):36176-80.
1999: CZ Yang; Mike Mueckler
ADP-ribosylation factor 6 (ARF6) defines two insulin-regulated secretory pathways in adipocytes.
The Journal of biological chemistry 1999;274(36):25297-300.
1999: M Sato; Mike Mueckler
A conserved amino acid motif (R-X-G-R-R) in the Glut1 glucose transporter is an important determinant of membrane topology.
The Journal of biological chemistry 1999;274(35):24721-5.
1999: Mike Mueckler; Carol Makepeace
Transmembrane segment 5 of the Glut1 glucose transporter is an amphipathic helix that forms part of the sugar permeation pathway.
The Journal of biological chemistry 1999;274(16):10923-6.
1999: BA Marshall; Polly A Hansen; Nancy J Ensor; M A Ogden; Mike Mueckler
GLUT-1 or GLUT-4 transgenes in obese mice improve glucose tolerance but do not prevent insulin resistance.
The American journal of physiology 1999;276(2 Pt 1):E390-400.
1998: Kelle H Moley; Maggie M-Y Chi; C M Knudson; S J Korsmeyer; Mike Mueckler
Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways.
Nature medicine 1998;4(12):1421-4.
1998: Polly A Hansen; Dong-Ho Han; BA Marshall; Lorraine A Nolte; May M Chen; Mike Mueckler; John O Holloszy
A high fat diet impairs stimulation of glucose transport in muscle. Functional evaluation of potential mechanisms.
The Journal of biological chemistry 1998;273(40):26157-63.
1998: H Inoue; Yukio Tanizawa; JC Wasson; PS Behn; K Kalidas; Ernesto Bernal-Mizrachi; Mike Mueckler; H Marshall; H Donis-Keller; P Crock; D Rogers; M Mikuni; H Kumashiro; K Higashi; G Sobue; Yoshitomo Oka; M Alan Permutt
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome).
Nature genetics 1998;20(2):143-8.
1998: M Sato; Richard C Hresko; Mike Mueckler
Testing the charge difference hypothesis for the assembly of a eucaryotic multispanning membrane protein.
The Journal of biological chemistry 1998;273(39):25203-8.
1998: Richard C Hresko; H Heimberg; Maggie M-Y Chi; Mike Mueckler
Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP.
The Journal of biological chemistry 1998;273(32):20658-68.
1998: Polly A Hansen; W Wang; BA Marshall; John O Holloszy; Mike Mueckler
Dissociation of GLUT4 translocation and insulin-stimulated glucose transport in transgenic mice overexpressing GLUT1 in skeletal muscle.
The Journal of biological chemistry 1998;273(29):18173-9.
1998: Kelle H Moley; Maggie M-Y Chi; Mike Mueckler
Maternal hyperglycemia alters glucose transport and utilization in mouse preimplantation embryos.
The American journal of physiology 1998;275(1 Pt 1):E38-47.
1998: CZ Yang; H Heimberg; Crislyn D'Souza-Schorey; Mike Mueckler; Philip D Stahl
Subcellular distribution and differential expression of endogenous ADP-ribosylation factor 6 in mammalian cells.
The Journal of biological chemistry 1998;273(7):4006-11.
1997: Mike Mueckler; Carol Makepeace
Identification of an amino acid residue that lies between the exofacial vestibule and exofacial substrate-binding site of the Glut1 sugar permeation pathway.
The Journal of biological chemistry 1997;272(48):30141-6.
1997: Mike Mueckler; Richard C Hresko; M Sato
Structure, function and biosynthesis of GLUT1.
Biochemical Society transactions 1997;25(3):951-4.
1997: J Ferrer; JC Wasson; K D Schoor; Mike Mueckler; H Donis-Keller; M Alan Permutt
Mapping novel pancreatic islet genes to human chromosomes.
Diabetes 1997;46(3):386-92.
1996: W Wang; Polly A Hansen; BA Marshall; John O Holloszy; Mike Mueckler
Insulin unmasks a COOH-terminal Glut4 epitope and increases glucose transport across T-tubules in skeletal muscle.
The Journal of cell biology 1996;135(2):415-30.
1996: Maria G Buse; Katherine A Robinson; BA Marshall; Mike Mueckler
Differential effects of GLUT1 or GLUT4 overexpression on hexosamine biosynthesis by muscles of transgenic mice.
The Journal of biological chemistry 1996;271(38):23197-202.
1996: Jason D Oliver; Richard C Hresko; Mike Mueckler; Stephen High
The glut 1 glucose transporter interacts with calnexin and calreticulin.
The Journal of biological chemistry 1996;271(23):13691-6.
1995: P M Haney; M A Levy; M S Strube; Mike Mueckler
Insulin-sensitive targeting of the GLUT4 glucose transporter in L6 myoblasts is conferred by its COOH-terminal cytoplasmic tail.
The Journal of cell biology 1995;129(3):641-58.
1995: Polly A Hansen; Eric Gulve; BA Marshall; J Gao; Jeffrey Pessin; John O Holloszy; Mike Mueckler
Skeletal muscle glucose transport and metabolism are enhanced in transgenic mice overexpressing the Glut4 glucose transporter.
The Journal of biological chemistry 1995;270(4):1679-84.
1995: P Hansen; Eric Arthur Gulve; J Gao; J Schluter; Mike Mueckler; John O Holloszy
Kinetics of 2-deoxyglucose transport in skeletal muscle: effects of insulin and contractions.
The American journal of physiology 1995;268(1 Pt 1):C30-5.
1995: J M Ren; BA Marshall; Mike Mueckler; M McCaleb; J M Amatruda; G I Shulman
Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice.
The Journal of clinical investigation 1995;95(1):429-32.
1994: Richard C Hresko; H Murata; BA Marshall; Mike Mueckler
Discrete structural domains determine differential endoplasmic reticulum to Golgi transit times for glucose transporter isoforms.
The Journal of biological chemistry 1994;269(51):32110-9.
1994: BA Marshall; Mike Mueckler
Differential effects of GLUT-1 or GLUT-4 overexpression on insulin responsiveness in transgenic mice.
The American journal of physiology 1994;267(5 Pt 1):E738-44.
1994: Mike Mueckler; W Weng; M Kruse
Glutamine 161 of Glut1 glucose transporter is critical for transport activity and exofacial ligand binding.
The Journal of biological chemistry 1994;269(32):20533-8.
1994: Richard C Hresko; M Kruse; M Strube; Mike Mueckler
Topology of the Glut 1 glucose transporter deduced from glycosylation scanning mutagenesis.
The Journal of biological chemistry 1994;269(32):20482-8.
1994: Eric Gulve; J M Ren; BA Marshall; J Gao; Polly A Hansen; John O Holloszy; Mike Mueckler
Glucose transport activity in skeletal muscles from transgenic mice overexpressing GLUT1. Increased basal transport is associated with a defective response to diverse stimuli that activate GLUT4.
The Journal of biological chemistry 1994;269(28):18366-70.
1994: Mike Mueckler; M Kruse; M Strube; A C Riggs; K C Chiu; M Alan Permutt
A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity.
The Journal of biological chemistry 1994;269(27):17765-7.
1993: BA Marshall; H Murata; Richard C Hresko; Mike Mueckler
Domains that confer intracellular sequestration of the Glut4 glucose transporter in Xenopus oocytes.
The Journal of biological chemistry 1993;268(35):26193-9.
1993: Pertti Ebeling; R Bourey; L Koranyi; Juha A Tuominen; Leif C Groop; J Henriksson; Mike Mueckler; A Sovijärvi; Veikko Koivisto
Mechanism of enhanced insulin sensitivity in athletes. Increased blood flow, muscle glucose transport protein (GLUT-4) concentration, and glycogen synthase activity.
The Journal of clinical investigation 1993;92(4):1623-31.
1993: BA Marshall; J M Ren; D W Johnson; E Michael Gibbs; Jay Lillquist; Walter Soeller; John O Holloszy; Mike Mueckler
Germline manipulation of glucose homeostasis via alteration of glucose transporter levels in skeletal muscle.
The Journal of biological chemistry 1993;268(25):18442-5.
1993: J M Ren; BA Marshall; Eric Gulve; J Gao; D W Johnson; John O Holloszy; Mike Mueckler
Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle.
The Journal of biological chemistry 1993;268(22):16113-5.
1993: Mike Mueckler
Glucokinase, glucose sensing, and diabetes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(3):784-5.
1992: L Koranyi; R Bourey; J Turk; Mike Mueckler; Rosalie A Veile
Differential expression of rat pancreatic islet beta-cell glucose transporter (GLUT 2), proinsulin and islet amyloid polypeptide genes after prolonged fasting, insulin-induced hypoglycaemia and dexamethasone treatment.
Diabetologia 1992;35(12):1125-32.
1992: Hannele Yki-Järvinen; H Vuorinen-Markkola; L Koranyi; R Bourey; K Tordjman; Mike Mueckler; A M Permutt; Veikko Koivisto
Defect in insulin action on expression of the muscle/adipose tissue glucose transporter gene in skeletal muscle of type 1 diabetic patients.
The Journal of clinical endocrinology and metabolism 1992;75(3):795-9.
1992: J C Garcia; M Strube; K Leingang; K Keller; Mike Mueckler
Amino acid substitutions at tryptophan 388 and tryptophan 412 of the HepG2 (Glut1) glucose transporter inhibit transport activity and targeting to the plasma membrane in Xenopus oocytes.
The Journal of biological chemistry 1992;267(11):7770-6.
1992: J W Tanner; K A Leingang; Mike Mueckler; K C Glenn
Cellular mechanism of the insulin-like effect of growth hormone in adipocytes. Rapid translocation of the HepG2-type and adipocyte/muscle glucose transporters.
The Biochemical journal 1992;282 ( Pt 1)():99-106.
1992: J Eriksson; L Koranyi; R Bourey; C Schalin-Jäntti; Elisabeth Widén; Mike Mueckler; A M Permutt; Leif C Groop
Insulin resistance in type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscle.
Diabetologia 1992;35(2):143-7.
1991: L I Koranyi; R E Bourey; H Vuorinen-Markkola; Veikko Koivisto; Mike Mueckler; M Alan Permutt; Hannele Yki-Järvinen
Level of skeletal muscle glucose transporter protein correlates with insulin-stimulated whole body glucose disposal in man.
Diabetologia 1991;34(10):763-5.
1991: P M Haney; J W Slot; R C Piper; David E James; Mike Mueckler
Intracellular targeting of the insulin-regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type.
The Journal of cell biology 1991;114(4):689-99.
1991: L Koranyi; R E Bourey; D James; Mike Mueckler; F T Fiedorek; M Alan Permutt
Glucose transporter gene expression in rat brain: Pretranslational changes associated with chronic insulin-induced hypoglycemia, fasting, and diabetes.
Molecular and cellular neurosciences 1991;2(3):244-52.
1991: P M Handley; Mike Mueckler; N R Siegel; Aaron Ciechanover; A L Schwartz
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):258-62.
1990: K M Tordjman; K A Leingang; Mike Mueckler
Differential regulation of the HepG2 and adipocyte/muscle glucose transporters in 3T3L1 adipocytes. Effect of chronic glucose deprivation.
The Biochemical journal 1990;271(1):201-7.
1990: R E Bourey; L Koranyi; D E James; Mike Mueckler; M Alan Permutt
Effects of altered glucose homeostasis on glucose transporter expression in skeletal muscle of the rat.
The Journal of clinical investigation 1990;86(2):542-7.
1990: L Koranyi; D James; Mike Mueckler; M Alan Permutt
Glucose transporter levels in spontaneously obese (db/db) insulin-resistant mice.
The Journal of clinical investigation 1990;85(3):962-7.
1989: K Keller; M Strube; Mike Mueckler
Functional expression of the human HepG2 and rat adipocyte glucose transporters in Xenopus oocytes. Comparison of kinetic parameters.
The Journal of biological chemistry 1989;264(32):18884-9.
1989: M Alan Permutt; L Koranyi; K Keller; P E Lacy; D W Scharp; Mike Mueckler
Cloning and functional expression of a human pancreatic islet glucose-transporter cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8688-92.
1989: K M Tordjman; K A Leingang; D E James; Mike Mueckler
Differential regulation of two distinct glucose transporter species expressed in 3T3-L1 adipocytes: effect of chronic insulin and tolbutamide treatment.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7761-5.
1989: D E James; M Strube; Mike Mueckler
Molecular cloning and characterization of an insulin-regulatable glucose transporter.
Nature 1989;338(6210):83-7.
1989: G W Gould; V Derechin; D E James; K Tordjman; S Ahern; E Michael Gibbs; Gustav E Lienhard; Mike Mueckler
Insulin-stimulated translocation of the HepG2/erythrocyte-type glucose transporter expressed in 3T3-L1 adipocytes.
The Journal of biological chemistry 1989;264(4):2180-4.