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Niels Behrendt

Research Profile

Chemicals & Drugs

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Mouse

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Anatomy

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Amino Acid Sequences

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Electrophoresis, Polyacrylamide Gel

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Signe Ingvarsen; Henrik J Jürgensen; Daniel H Madsen; Ludovic Maertens; Maria C Melander; Agnès Noel; Astrid Porse; Lars H Engelholm; Charlotte Erpicum; Henrik Gårdsvoll; Kenn Holmbeck; Gunilla Høyer-Hansen; Niels Behrendt
Targeting a Single Function of the Multifunctional Matrix Metalloprotease MT1-MMP: IMPACT ON LYMPHANGIOGENESIS.
Daniel H Madsen; Maria C Melander; Birgitte Rønø; Ben Vainer; Thomas H Bugge; Kristoffer Lihme Egerod; Lars H Engelholm; Andreas Hald; Signe Ingvarsen; Henrik J Jürgensen; Charlotte A Madsen; Niels Behrendt
Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis.
Ida Katrine Lund; Daniel H Madsen; Jesper Pass; Morten G Rasch; Niels Behrendt; Lars H Engelholm; Signe Ingvarsen; Gunilla Høyer-Hansen
Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo.

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All Publications

2013: Signe Ingvarsen; Henrik J Jürgensen; Daniel H Madsen; Ludovic Maertens; Maria C Melander; Agnès Noel; Astrid Porse; Lars H Engelholm; Charlotte Erpicum; Henrik Gårdsvoll; Kenn Holmbeck; Gunilla Høyer-Hansen; Niels Behrendt
Targeting a Single Function of the Multifunctional Matrix Metalloprotease MT1-MMP: IMPACT ON LYMPHANGIOGENESIS.
The Journal of biological chemistry 2013;288(15):10195-204.
2012: Daniel H Madsen; Maria C Melander; Birgitte Rønø; Ben Vainer; Thomas H Bugge; Kristoffer Lihme Egerod; Lars H Engelholm; Andreas Hald; Signe Ingvarsen; Henrik J Jürgensen; Charlotte A Madsen; Niels Behrendt
Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis.
The Journal of pathology 2012;227(1):94-105.
2012: Ida Katrine Lund; Daniel H Madsen; Jesper Pass; Morten G Rasch; Niels Behrendt; Lars H Engelholm; Signe Ingvarsen; Gunilla Høyer-Hansen
Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo.
Frontiers in pharmacology 2012;3():122.
2011: Henrik Gårdsvoll; Benedikte Jacobsen; Mette C Kriegbaum; Niels Behrendt; Lars H Engelholm; Søren Østergaard; Michael Ploug
Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction.
The Journal of biological chemistry 2011;286(38):33544-56.
2011: Henrik J Jürgensen; Daniel H Madsen; Maria C Melander; Laszlo Patthy; Lars H Engelholm; Henrik Gårdsvoll; Signe Ingvarsen; Niels Behrendt
A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180.
The Journal of biological chemistry 2011;286(37):32736-48.
2011: Daniel H Madsen; Maria C Melander; Amanda Moyer; Niels Behrendt; Thomas H Bugge; Sven Burgdorf; Peter Garred; Christian Honoré; Signe Ingvarsen; Henrik J Jürgensen; Lars Kjøller; Charlotte A Madsen; Lars H Engelholm
The non-phagocytic route of collagen uptake: a distinct degradation pathway.
The Journal of biological chemistry 2011;286(30):26996-7010.
2009: Ludmila Szabova; Susan S Yamada; Helen Wimer; Kali Chrysovergis; Signe Ingvarsen; Niels Behrendt; Lars H Engelholm; Kenn Holmbeck
MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(11):1905-16.
2009: Lars H Engelholm; Signe Ingvarsen; Henrik J Jürgensen; Thore Hillig; Daniel H Madsen; Boye Nielsen; Niels Behrendt
The collagen receptor uPARAP/Endo180.
Frontiers in bioscience : a journal and virtual library 2009;14():2103-14.
2008: Ida K Lund; Annika Jögi; Birgitte Rønø; Morten G Rasch; Leif R Lund; Kasper Almholt; Henrik Gårdsvoll; Niels Behrendt; John Rømer; Gunilla Høyer-Hansen
Antibody-mediated targeting of the urokinase-type plasminogen activator proteolytic function neutralizes fibrinolysis in vivo.
The Journal of biological chemistry 2008;283(47):32506-15.
2008: Signe Ingvarsen; Daniel H Madsen; Thore Hillig; Leif R Lund; Kenn Holmbeck; Niels Behrendt; Lars H Engelholm
Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells.
Biological chemistry 2008;389(7):943-53.
2008: Thore Hillig; Lars H Engelholm; Signe Ingvarsen; Daniel H Madsen; Henrik Gårdsvoll; Jens Knud Larsen; Michael Ploug; Keld Danø; Lars Kjøller; Niels Behrendt
A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor.
The Journal of biological chemistry 2008;283(22):15217-23.
2007: Daniel H Madsen; Lars H Engelholm; Signe Ingvarsen; Thore Hillig; Rebecca Wagenaar-Miller; Lars Kjøller; Henrik Gårdsvoll; Gunilla Høyer-Hansen; Kenn Holmbeck; Thomas H Bugge; Niels Behrendt
Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation.
The Journal of biological chemistry 2007;282(37):27037-45.
2007: Rebecca Wagenaar-Miller; Lars H Engelholm; Julie Gavard; Susan S Yamada; J Silvio Gutkind; Niels Behrendt; Thomas H Bugge; Kenn Holmbeck
Complementary roles of intracellular and pericellular collagen degradation pathways in vivo.
Molecular and cellular biology 2007;27(18):6309-22.
2007: Jay Sulek; Rebecca Wagenaar-Miller; Jessica Shireman; Alfredo A Molinolo; Daniel H Madsen; Lars H Engelholm; Niels Behrendt; Thomas H Bugge
Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(4):347-53.
2005: Alejandro Curino; Lars H Engelholm; Susan S Yamada; Kenn Holmbeck; Leif R Lund; Alfredo A Molinolo; Niels Behrendt; Boye Nielsen; Thomas H Bugge
Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy.
The Journal of cell biology 2005;169(6):977-85.
2005: Keld Danø; Niels Behrendt; Gunilla Høyer-Hansen; Morten Johnsen; Leif R Lund; Michael Ploug; John Rømer
Plasminogen activation and cancer.
Thrombosis and haemostasis 2005;93(4):676-81.
2004: Lene Udby; Ole E Sørensen; Jesper Pass; Anders H Johnsen; Niels Behrendt; Niels Borregaard; Lars Kjeldsen
Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma.
Biochemistry 2004;43(40):12877-86.
2004: Niels Behrendt
The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling.
Biological chemistry 2004;385(2):103-36.
2004: Lars Kjøller; Lars H Engelholm; Maria Høyer-Hansen; Keld Danø; Thomas H Bugge; Niels Behrendt
uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV.
Experimental cell research 2004;293(1):106-16.
2003: Niels Behrendt; Karin List; Peter A Andreasen; Keld Danø
The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: rescue of activity through reciprocal pro-enzyme activation.
The Biochemical journal 2003;371(Pt 2):277-87.
2003: Lars H Engelholm; Karin List; Sarah Netzel-Arnett; Edna Cukierman; David J Mitola; Hannah Aaronson; Lars Kjøller; Jørgen K Larsen; Kenneth M Yamada; Dudley K Strickland; Kenn Holmbeck; Keld Danø; Henning Birkedal-Hansen; Niels Behrendt; Thomas H Bugge
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion.
The Journal of cell biology 2003;160(7):1009-15.
2002: Karin List; Christian Haudenschild; Roman Szabo; WanJun Chen; Sharon M Wahl; William D Swaim; Lars H Engelholm; Niels Behrendt; Thomas H Bugge
Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis.
Oncogene 2002;21(23):3765-79.
2002: Boye Nielsen; Fritz Rank; Lars H Engelholm; Arne Holm; Keld Danø; Niels Behrendt
Urokinase receptor-associated protein (uPARAP) is expressed in connection with malignant as well as benign lesions of the human breast and occurs in specific populations of stromal cells.
International journal of cancer. Journal international du cancer 2002;98(5):656-64.
2001: Lars H Engelholm; Boye Nielsen; Sarah Netzel-Arnett; Helene Solberg; X D Chen; J M Lopez Garcia; Carlos Lopez-Otin; M F Young; Henning Birkedal-Hansen; Keld Danø; Leif R Lund; Niels Behrendt; Thomas H Bugge
The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis.
Laboratory investigation; a journal of technical methods and pathology 2001;81(10):1403-14.
2001: Gunilla Høyer-Hansen; U Pessara; Arne Holm; Jesper Pass; U Weidle; Keld Danø; Niels Behrendt
Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor.
The Biochemical journal 2001;358(Pt 3):673-9.
2001: Lars H Engelholm; Niels Behrendt
Differential binding of urokinase and peptide antagonists to the urokinase receptor: evidence from characterization of the receptor in four primate species.
Biological chemistry 2001;382(3):435-42.
2001: Lars H Engelholm; Boye Nielsen; Keld Danø; Niels Behrendt
The urokinase receptor associated protein (uPARAP/endo180): a novel internalization receptor connected to the plasminogen activation system.
Trends in cardiovascular medicine 2001;11(1):7-13.
2000: Karin List; Ole N Jensen; Thomas H Bugge; Leif R Lund; Michael Ploug; Keld Danø; Niels Behrendt
Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice.
Biochemistry 2000;39(3):508-15.
2000: Niels Behrendt; Ole N Jensen; Lars H Engelholm; E Mørtz; M Mann; Keld Danø
A urokinase receptor-associated protein with specific collagen binding properties.
The Journal of biological chemistry 2000;275(3):1993-2002.
1999: Karin List; Gunilla Høyer-Hansen; E Rønne; Keld Danø; Niels Behrendt
Different mechanisms are involved in the antibody mediated inhibition of ligand binding to the urokinase receptor: a study based on biosensor technology.
Journal of immunological methods 1999;222(1-2):125-33.
1997: Gunilla Høyer-Hansen; Niels Behrendt; Michael Ploug; Keld Danø; K T Preissner
The intact urokinase receptor is required for efficient vitronectin binding: receptor cleavage prevents ligand interaction.
FEBS letters 1997;420(1):79-85.
1997: H De Witte; Helle Pappot; Nils Brünner; J Grøndahl-Hansen; G Hoyer-Hansen; Niels Behrendt; B Guldhammer-Skov; Fred C G J Sweep; Th J Benraad; Keld Danø
ELISA for complexes between urokinase-type plasminogen activator and its receptor in lung cancer tissue extracts.
International journal of cancer. Journal international du cancer 1997;72(3):416-23.
1997: Niels Behrendt; Keld Danø
Reply to comment on 'Effect of purified, soluble urokinase receptor on the plasminogen-prourokinase activation system' (A. A-R. Higazi)
FEBS letters 1997;402(2-3):293-4.
1997: Gunilla Høyer-Hansen; Michael Ploug; Niels Behrendt; E Rønne; Keld Danø
Cell-surface acceleration of urokinase-catalyzed receptor cleavage.
European journal of biochemistry / FEBS 1997;243(1-2):21-6.
1997: T Plesner; Niels Behrendt; Michael Ploug
Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR.
Stem cells (Dayton, Ohio) 1997;15(6):398-408.
1996: Niels Behrendt; E Ronne; K Dano
Domain interplay in the urokinase receptor. Requirement for the third domain in high affinity ligand binding and demonstration of ligand contact sites in distinct receptor domains.
The Journal of biological chemistry 1996;271(37):22885-94.
1996: Niels Behrendt; Keld Danø
Effect of purified, soluble urokinase receptor on the plasminogen-prourokinase activation system.
FEBS letters 1996;393(1):31-6.
1995: Niels Behrendt; Jens Modvig
The lethal paraphiliac syndrome. Accidental autoerotic deaths in Denmark 1933-1990.
The American journal of forensic medicine and pathology 1995;16(3):232-7.
1995: Niels Behrendt; E Rønne; Keld Danø
The structure and function of the urokinase receptor, a membrane protein governing plasminogen activation on the cell surface.
Biological chemistry Hoppe-Seyler 1995;376(5):269-79.
1994: E Rønne; Niels Behrendt; Michael Ploug; Hans Jørgen Nielsen; E Wöllisch; U Weidle; Keld Danø; Gunilla Høyer-Hansen
Quantitation of the receptor for urokinase plasminogen activator by enzyme-linked immunosorbent assay.
Journal of immunological methods 1994;167(1-2):91-101.
1994: U H Weidle; E Wöllisch; E Rønne; Michael Ploug; Niels Behrendt; Teun J de Vries; Paul H A Quax; Jan H Verheijen; Goos N P van Muijen; Dirk J Ruiter
Studies on functional and structural role of urokinase receptor and other components of the plasminogen activation system in malignancy.
Annales de biologie clinique 1994;52(11):775-82.
1993: Niels Behrendt; E Rønne; Keld Danø
A novel, specific pro-urokinase complex on monocyte-like cells, detected by transglutaminase-catalyzed cross-linking.
FEBS letters 1993;336(3):394-6.
1993: Niels Behrendt; E Rønne; Keld Danø
Binding of the urokinase-type plasminogen activator to its cell surface receptor is inhibited by low doses of suramin.
The Journal of biological chemistry 1993;268(8):5985-9.
1993: V Ellis; Niels Behrendt; Keld Danø
Cellular receptor for urokinase-type plasminogen activator: function in cell-surface proteolysis.
Methods in enzymology 1993;223():223-33.
1993: Niels Behrendt; Michael Ploug; E Rønne; Gunilla Høyer-Hansen; Keld Danø
Cellular receptor for urokinase-type plasminogen activator: protein structure.
Methods in enzymology 1993;223():207-22.
1992: Gunilla Høyer-Hansen; E Rønne; H Solberg; Niels Behrendt; Michael Ploug; Leif R Lund; V Ellis; Keld Danø
Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain.
The Journal of biological chemistry 1992;267(25):18224-9.
1992: H Solberg; D Løber; J Eriksen; Michael Ploug; E Rønne; Niels Behrendt; Keld Danø; Gunilla Høyer-Hansen
Identification and characterization of the murine cell surface receptor for the urokinase-type plasminogen activator.
European journal of biochemistry / FEBS 1992;205(2):451-8.
1991: E Rønne; Niels Behrendt; V Ellis; Michael Ploug; Keld Danø; Gunilla Høyer-Hansen
Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor.
FEBS letters 1991;288(1-2):233-6.
1991: V Ellis; Niels Behrendt; Keld Danø
Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor.
The Journal of biological chemistry 1991;266(19):12752-8.
1991: Michael Ploug; Niels Behrendt; D Løber; Keld Danø
Protein structure and membrane anchorage of the cellular receptor for urokinase-type plasminogen activator.
Seminars in thrombosis and hemostasis 1991;17(3):183-93.
1991: Niels Behrendt; Michael Ploug; L Patthy; G Houen; F Blasi; Keld Danø
The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator.
The Journal of biological chemistry 1991;266(12):7842-7.
1991: Leif R Lund; E Rønne; A L Roldan; Niels Behrendt; John Rømer; F Blasi; Keld Danø
Urokinase receptor mRNA level and gene transcription are strongly and rapidly increased by phorbol myristate acetate in human monocyte-like U937 cells.
The Journal of biological chemistry 1991;266(8):5177-81.
1991: Michael Ploug; E Rønne; Niels Behrendt; A L Jensen; F Blasi; Keld Danø
Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol.
The Journal of biological chemistry 1991;266(3):1926-33.
1990: F Blasi; Niels Behrendt; M V Cubellis; V Ellis; Leif R Lund; M T Masucci; L B Møller; D P Olson; Nina Pedersen; Michael Ploug
The urokinase receptor and regulation of cell surface plasminogen activation.
Cell differentiation and development : the official journal of the International Society of Developmental Biologists 1990;32(3):247-53.
1990: Elliot S Barnathan; Alice Kuo; Katalin Karikó; L Rosenfeld; S C Murray; Niels Behrendt; E Rønne; David Weiner; Jack Henkin; Douglas B Cines
Characterization of human endothelial cell urokinase-type plasminogen activator receptor protein and messenger RNA.
Blood 1990;76(9):1795-806.
1990: V Ellis; T C Wun; Niels Behrendt; E Rønne; Keld Danø
Inhibition of receptor-bound urokinase by plasminogen-activator inhibitors.
The Journal of biological chemistry 1990;265(17):9904-8.
1990: Niels Behrendt; E Rønne; Michael Ploug; Thomas Petri; D Løber; L S Nielsen; Wolf-Dieter Schleuning; F Blasi; E Appella; Keld Danø
The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants.
The Journal of biological chemistry 1990;265(11):6453-60.
1990: Steen H Hansen; Niels Behrendt; Keld Danø; P Kristensen
Localization of urokinase-type plasminogen activator receptor on U937 cells: phorbol ester PMA induces heterogeneity.
Experimental cell research 1990;187(2):255-62.
1990: A L Roldan; M V Cubellis; M T Masucci; Niels Behrendt; Leif R Lund; Keld Danø; Ettore Appella; F Blasi
Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.
The EMBO journal 1990;9(2):467-74.
1989: Ross W Stephens; J Pöllänen; H Tapiovaara; K C Leung; P S Sim; E M Salonen; E Rønne; Niels Behrendt; Keld Danø; Antti Vaheri
Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactants.
The Journal of cell biology 1989;108(5):1987-95.
1989: R Picone; E L Kajtaniak; L S Nielsen; Niels Behrendt; M R Mastronicola; M V Cubellis; Maria Patrizia Stoppelli; S Pedersen; Keld Danø; F Blasi
Regulation of urokinase receptors in monocytelike U937 cells by phorbol ester phorbol myristate acetate.
The Journal of cell biology 1989;108(2):693-702.
1988: L S Nielsen; G M Kellerman; Niels Behrendt; R Picone; Keld Danø; F Blasi
A 55,000-60,000 Mr receptor protein for urokinase-type plasminogen activator. Identification in human tumor cell lines and partial purification.
The Journal of biological chemistry 1988;263(5):2358-63.
1987: Niels Behrendt; O C Hansen; Michael Ploug; V Barkholt; C Koch
Localization and functional significance of a polymorphic determinant in the third component of human complement.
Molecular immunology 1987;24(10):1097-103.