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Christian Mühlfeld

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Christian Mühlfeld; Burkert Pieske; Heiner Post; Julia Schipke; Albrecht Schmidt; Simon Sedej
Hypoinnervation is an early event in experimental myocardial remodelling induced by pressure overload.
Thorsten Wittwer; Yeong-Hoon Choi; Konrad Frank; Navid Madershahian; Christian Mühlfeld; Jochen Müller-Ehmsen; Klaus Neef; Matthias Ochs; Parwis Rahmanian; Thorsten Wahlers
Surfactant application in experimental lung transplantation.
Christian Mühlfeld; Lars Knudsen; Matthias Ochs
Stereology and morphometry of lung tissue.

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All Publications

2013: Christian Mühlfeld; Burkert Pieske; Heiner Post; Julia Schipke; Albrecht Schmidt; Simon Sedej
Hypoinnervation is an early event in experimental myocardial remodelling induced by pressure overload.
Journal of anatomy 2013;222(6):634-44.
2013: Thorsten Wittwer; Yeong-Hoon Choi; Konrad Frank; Navid Madershahian; Christian Mühlfeld; Jochen Müller-Ehmsen; Klaus Neef; Matthias Ochs; Parwis Rahmanian; Thorsten Wahlers
Surfactant application in experimental lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2013;32(3):355-9.
2013: Christian Mühlfeld; Lars Knudsen; Matthias Ochs
Stereology and morphometry of lung tissue.
Methods in molecular biology (Clifton, N.J.) 2013;931():367-90.
2012: Christian Mühlfeld; Fiona A Murphy; Craig A Poland; Barbara Rothen-Rutishauser; Christina Brandenberger; Rodger Duffin; Peter Gehr; Ken Donaldson
Differential effects of long and short carbon nanotubes on the gas-exchange region of the mouse lung.
Nanotoxicology 2012;6():867-79.
2012: Tilman Graulich; Gerald Hoefler; Gabriela Krasteva; Clemens Ruppert; Lars Wessels; Suman Kumar Das; Christian Mühlfeld
Cancer cachexia alters intracellular surfactant metabolism but not total alveolar surface area.
Histochemistry and cell biology 2012;138(5):803-13.
2012: Belal A Mohamed; Christian Mühlfeld; Wolfram-Hubertus Zimmermann; Amal Z Barakat; Reginald E Bittner; Wolfgang Engel; Mark Hünlich; Lars S Maier; Ibrahim M Adham
Targeted disruption of Hspa4 gene leads to cardiac hypertrophy and fibrosis.
Journal of molecular and cellular cardiology 2012;53(4):459-68.
2012: Carina Gruber; Karin Kohlstedt; Wolfgang Kummer; Annemarieke E Loot; Ingrid Fleming; Christian Mühlfeld
Stereological characterization of left ventricular cardiomyocytes, capillaries, and innervation in the nondiabetic, obese mouse.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2012;21(4):346-54.
2012: Chinmoy Patra; Sarmistha Talukdar; Siva R Velagala; Banani Kundu; Subhas C Kundu; Christian Mühlfeld; Tatyana Novoyatleva; Felix B Engel
Silk protein fibroin from Antheraea mylitta for cardiac tissue engineering.
Biomaterials 2012;33(9):2673-80.
2011: Ling Li; Rong Li; Christian Mühlfeld; Bernd Niemann; Ruping Pan; Ying Chen; Denise Hilfiker-Kleiner; Susanne Rohrbach
Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle.
Basic research in cardiology 2011;106(6):1221-34.
2011: Chinmoy Patra; Liliana Schaefer; Machteld J van Amerongen; Florian Diehl; Fulvia Ferrazzi; Benno Jungblut; Christian Mühlfeld; Tatyana Novoyatleva; Felix B Engel
Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish.
Development (Cambridge, England) 2011;138(20):4499-509.
2011: Christian Mühlfeld; Christina Brandenberger
Uptake of nanoparticles by cells: do you know their number?
Nanomedicine (London, England) 2011;6(7):1149-51; author reply 1153-4.
2011: Gabriela Krasteva; Nelli Baal; Armin Braun; Brendan J Canning; Holger Hackstein; Petra Hartmann; Ines Ibanez-Tallon; Michael Kotlikoff; Christian Mühlfeld; Tamara Papadakis; Kirstin Schliecker; Burkhard Schütz; Yvonne N Tallini; Tibor Z Veres; Eberhard Weihe; Wolfgang Kummer
Cholinergic chemosensory cells in the trachea regulate breathing.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(23):9478-83.
2011: J Volkmann; D Müller; C Feuerstacke; Sabine Kliesch; Martin Bergmann; Christian Mühlfeld; Ralf Middendorff
Disturbed spermatogenesis associated with thickened lamina propria of seminiferous tubules is not caused by dedifferentiation of myofibroblasts.
Human reproduction (Oxford, England) 2011;26(6):1450-61.
2011: Christian Mühlfeld; Suman Kumar Das; Frank R Heinzel; Albrecht Schmidt; Heiner Post; Silvia Schauer; Tamara Papadakis; Wolfgang Kummer; Gerald Hoefler
Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart.
PloS one 2011;6(5):e20424.
2010: Jörg Mühling; Martina Tiefenbach; José López-Barneo; José I Piruat; Paula García-Flores; Uwe Pfeil; Barbara Gries; Christian Mühlfeld; Markus A Weigand; Wolfgang Kummer; Norbert Weissmann; Renate Paddenberg
Mitochondrial complex II participates in normoxic and hypoxic regulation of α-keto acids in the murine heart.
Journal of molecular and cellular cardiology 2010;49(6):950-61.
2010: André Wirkes; Kristina Jung; Matthias Ochs; Christian Mühlfeld
Allometry of the mammalian intracellular pulmonary surfactant system.
Journal of applied physiology (Bethesda, Md. : 1985) 2010;109(6):1662-9.
2010: Dimitri Vanhecke; Gudrun Herrmann; Werner Graber; Therese Hillmann-Marti; Christian Mühlfeld; Daniel Studer; Matthias Ochs
Lamellar body ultrastructure revisited: high-pressure freezing and cryo-electron microscopy of vitreous sections.
Histochemistry and cell biology 2010;134(4):319-26.
2010: J N Maina; J B West; S Orgeig; N J Foot; C B Daniels; S G Kiama; P Gehr; Christian Mühlfeld; F Blank; L Müller; A Lehmann; C Brandenberger; Barbara Rothen-Rutishauser
Recent advances into understanding some aspects of the structure and function of mammalian and avian lungs.
Physiological and biochemical zoology : PBZ 2010;83(5):792-807.
2010: Julia K Zimmer; Suzan Dahdal; Christian Mühlfeld; Ivo P Bergmann; Mathias Gugger; Uyen Huynh-Do
Lymphangiogenesis is upregulated in kidneys of patients with multiple myeloma.
Anatomical record (Hoboken, N.J. : 2007) 2010;293(9):1497-505.
2010: Christina Brandenberger; Christian Mühlfeld; Zulqurnain Ali; Anke-Gabriele Lenz; Otmar Schmid; Wolfgang J Parak; Peter Gehr; Barbara Rothen-Rutishauser
Quantitative evaluation of cellular uptake and trafficking of plain and polyethylene glycol-coated gold nanoparticles.
Small (Weinheim an der Bergstrasse, Germany) 2010;6(15):1669-78.
2010: Christian Mühlfeld; Ewald R Weibel; Ute Hahn; Wolfgang Kummer; Jens R Nyengaard; Matthias Ochs
Is length an appropriate estimator to characterize pulmonary alveolar capillaries? A critical evaluation in the human lung.
Anatomical record (Hoboken, N.J. : 2007) 2010;293(7):1270-5.
2010: Christian Mühlfeld; Cenk Cetegen; Sigrid Freese; Rolf Volkmann; Gerhard Hellige; Friedrich Vetterlein
Phosphorylation of extrajunctional Cx43 in ischemic-preconditioned rat hearts.
The Journal of surgical research 2010;162(1):e1-8.
2010: Christian Mühlfeld; Tamara Papadakis; Gabriela Krasteva; Jens Randel Nyengaard; Ute Hahn; Wolfgang Kummer
An unbiased stereological method for efficiently quantifying the innervation of the heart and other organs based on total length estimations.
Journal of applied physiology (Bethesda, Md. : 1985) 2010;108(5):1402-9.
2010: Christian Mühlfeld; Laura Becker; Christine Bussinger; Marcel Vollroth; Ragi Nagib; Inga-Marie Schaefer; Lars Knudsen; Joachim Richter; Navid Madershahian; Thorsten Wahlers; Thorsten Wittwer; Matthias Ochs
Exogenous surfactant in ischemia/reperfusion: effects on endogenous surfactant pools.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010;29(3):327-34.
2010: Christian Mühlfeld; Jens Randel Nyengaard; Terry M Mayhew
A review of state-of-the-art stereology for better quantitative 3D morphology in cardiac research.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2010;19(2):65-82.
2010: Christina Brandenberger; Martin J D Clift; Dimitri Vanhecke; Christian Mühlfeld; Vicki Stone; Peter Gehr; Barbara Rothen-Rutishauser
Intracellular imaging of nanoparticles: is it an elemental mistake to believe what you see?
Particle and fibre toxicology 2010;7():15.
2010: Christian Mühlfeld
High-pressure freezing, chemical fixation and freeze-substitution for immuno-electron microscopy.
Methods in molecular biology (Clifton, N.J.) 2010;611():87-101.
2010: C Brandenberger; Barbara Rothen-Rutishauser; Christian Mühlfeld; O Schmid; G A Ferron; K L Maier; P Gehr; A-G Lenz
Effects and uptake of gold nanoparticles deposited at the air-liquid interface of a human epithelial airway model.
Toxicology and applied pharmacology 2010;242(1):56-65.
2009: Barbara Rothen-Rutishauser; Robert N Grass; Fabian Blank; Ludwig K Limbach; Christian Mühlfeld; Christina Brandenberger; David O Raemy; Peter Gehr; Wendelin J Stark
Direct combination of nanoparticle fabrication and exposure to lung cell cultures in a closed setup as a method to simulate accidental nanoparticle exposure of humans.
Environmental science & technology 2009;43(7):2634-40.
2009: Terry M Mayhew; Christian Mühlfeld; Dimitri Vanhecke; Matthias Ochs
A review of recent methods for efficiently quantifying immunogold and other nanoparticles using TEM sections through cells, tissues and organs.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2009;191(2):153-70.
2009: Henriette Brinks; Hendrik T Tevaearai; Christian Mühlfeld; Daniela Bertschi; Brigitta Gahl; Thierry Carrel; Marie Noelle Giraud
Contractile function is preserved in unloaded hearts despite atrophic remodeling.
The Journal of thoracic and cardiovascular surgery 2009;137(3):742-6.
2009: Christian Mühlfeld; I-M Schaefer; L Becker; C Bussinger; M Vollroth; A Bosch; R Nagib; N Madershahian; Joachim Richter; Thorsten Wahlers; Thorsten Wittwer; Matthias Ochs
Pre-ischaemic exogenous surfactant reduces pulmonary injury in rat ischaemia/reperfusion.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(3):625-33.
2009: Lars Knudsen; Katharina Wucherpfennig; Rose-Marie Mackay; Paul Townsend; Christian Mühlfeld; Joachim Richter; Samuel Hawgood; Kenneth Reid; Howard Clark; Matthias Ochs
A recombinant fragment of human surfactant protein D lacking the short collagen-like stalk fails to correct morphological alterations in lungs of SP-D deficient mice.
Anatomical record (Hoboken, N.J. : 2007) 2009;292(2):183-9.
2009: Carsten Schleh; Christian Mühlfeld; Karin Pulskamp; Andreas Schmiedl; Matthias Nassimi; Hans D Lauenstein; Armin Braun; Norbert Krug; Veit J Erpenbeck; Jens M Hohlfeld
The effect of titanium dioxide nanoparticles on pulmonary surfactant function and ultrastructure.
Respiratory research 2009;10():90.
2009: Christina Brandenberger; Barbara Rothen-Rutishauser; Fabian Blank; Peter Gehr; Christian Mühlfeld
Particles induce apical plasma membrane enlargement in epithelial lung cell line depending on particle surface area dose.
Respiratory research 2009;10():22.
2008: Barbara Rothen-Rutishauser; Fabian Blank; Christian Mühlfeld; Peter Gehr
In vitro models of the human epithelial airway barrier to study the toxic potential of particulate matter.
Expert opinion on drug metabolism & toxicology 2008;4(8):1075-89.
2008: Christian Mühlfeld; Peter Gehr; Barbara Rothen-Rutishauser
Translocation and cellular entering mechanisms of nanoparticles in the respiratory tract.
Swiss medical weekly 2008;138(27-28):387-91.
2008: Christian Mühlfeld; Barbara Rothen-Rutishauser; Fabian Blank; Dimitri Vanhecke; Matthias Ochs; Peter Gehr
Interactions of nanoparticles with pulmonary structures and cellular responses.
American journal of physiology. Lung cellular and molecular physiology 2008;294(5):L817-29.
2008: Christian Mühlfeld; Oliver J Liakopoulos; Inga-Marie Schaefer; Friedrich A Schöndube; Joachim Richter; Hilmar Dörge
Methylprednisolone fails to preserve pulmonary surfactant and blood-air barrier integrity in a porcine cardiopulmonary bypass model.
The Journal of surgical research 2008;146(1):57-65.
2008: Nicolas Regamey; Matthias Ochs; Tom N Hilliard; Christian Mühlfeld; Nikki Cornish; Louise Fleming; Sejal Saglani; Eric W F W Alton; Andrew Bush; Peter K Jeffery; Jane C Davies
Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis.
American journal of respiratory and critical care medicine 2008;177(8):837-43.
2008: Niels Dreyer; Christian Mühlfeld; Antonia Fehrenbach; Thomas Pech; Sebastian von Berg; Ragi Nagib; Joachim Richter; Thorsten Wittwer; Thorsten Wahlers; Matthias Ochs
Exogenous surfactant application in a rat lung ischemia reperfusion injury model: effects on edema formation and alveolar type II cells.
Respiratory research 2008;9():5.
2008: Judith Christina Eisele; Inga-Marie Schaefer; Jens Randel Nyengaard; Heiner Post; David Liebetanz; Annemarie Brüel; Christian Mühlfeld
Effect of voluntary exercise on number and volume of cardiomyocytes and their mitochondria in the mouse left ventricle.
Basic research in cardiology 2008;103(1):12-21.
2007: Dominique Singer; Christian Mühlfeld
Perinatal adaptation in mammals: the impact of metabolic rate.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2007;148(4):780-4.
2007: Andreas Schmiedl; Gertrud Vieten; Christian Mühlfeld; Wolfgang Bernhard
Distribution of intracellular and secreted surfactant during postnatal rat lung development.
Pediatric pulmonology 2007;42(6):548-62.
2007: Christian Mühlfeld; Katharina Müller; Lars-Peder Pallesen; Tim Sandhaus; Navis Madershahian; Joachim Richter; Thorsten Wahlers; Thorsten Wittwer; Matthias Ochs
Impact of preservation solution on the extent of blood-air barrier damage and edema formation in experimental lung transplantation.
Anatomical record (Hoboken, N.J. : 2007) 2007;290(5):491-500.
2007: Christian Mühlfeld; Terry M Mayhew; Peter Gehr; Barbara Rothen-Rutishauser
A novel quantitative method for analyzing the distributions of nanoparticles between different tissue and intracellular compartments.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2007;20(4):395-407.
2007: Christian Mühlfeld; Barbara Rothen-Rutishauser; Dimitri Vanhecke; Fabian Blank; Peter Gehr; Matthias Ochs
Visualization and quantitative analysis of nanoparticles in the respiratory tract by transmission electron microscopy.
Particle and fibre toxicology 2007;4():11.
2007: Lars Knudsen; Matthias Ochs; Rosemarie Mackay; Paul Townsend; Roona Deb; Christian Mühlfeld; Joachim Richter; Fabian Gilbert; Samuel Hawgood; Kenneth Reid; Howard Clark
Truncated recombinant human SP-D attenuates emphysema and type II cell changes in SP-D deficient mice.
Respiratory research 2007;8():70.
2007: Barbara Rothen-Rutishauser; Christian Mühlfeld; Fabian Blank; Claudia Musso; Peter Gehr
Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model.
Particle and fibre toxicology 2007;4():9.
2007: Christian Mühlfeld; Marianne Geiser; Nadine Kapp; Peter Gehr; Barbara Rothen-Rutishauser
Re-evaluation of pulmonary titanium dioxide nanoparticle distribution using the "relative deposition index": Evidence for clearance through microvasculature.
Particle and fibre toxicology 2007;4():7.
2006: Thorsten Wittwer; Ulrich F W Franke; Tim Sandhaus; Jan Groetzner; Justus T Strauch; Jens Wippermann; Matthias Ochs; Christian Mühlfeld; Angelika Börner; Sibylle Streck; Thorsten Wahlers
Endobronchial donor pre-treatment with ventavis: is a second administration during reperfusion beneficial to optimize post-ischemic function of non-heart beating donor lungs?
The Journal of surgical research 2006;136(1):136-42.
2006: Christian Mühlfeld; Joachim Richter
High-pressure freezing and freeze substitution of rat myocardium for immunogold labeling of connexin 43.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2006;288(10):1059-67.
2006: Frank Brasch; Sven Schimanski; Christian Mühlfeld; Stefan Barlage; Thomas Langmann; Charalampos Aslanidis; Alfred Boettcher; Ashraf Dada; Horst Schroten; Eva Mildenberger; Eric Prueter; Manfred Ballmann; Matthias Ochs; Georg Johnen; Matthias Griese; Gerd Schmitz
Alteration of the pulmonary surfactant system in full-term infants with hereditary ABCA3 deficiency.
American journal of respiratory and critical care medicine 2006;174(5):571-80.
2006: Oliver J Liakopoulos; Nils Teucher; Christian Mühlfeld; Peter Middel; Gerd Heusch; Friedrich A Schoendube; Hilmar Dörge
Prevention of TNFalpha-associated myocardial dysfunction resulting from cardiopulmonary bypass and cardioplegic arrest by glucocorticoid treatment.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2006;30(2):263-70.
2006: Friedrich Vetterlein; Christian Mühlfeld; Cenk Cetegen; Rolf Volkmann; Christina Schrader; Gerhard Hellige
Redistribution of connexin43 in regional acute ischemic myocardium: influence of ischemic preconditioning.
American journal of physiology. Heart and circulatory physiology 2006;291(2):H813-9.
2006: Christian Mühlfeld; Michele Urru; Randi Rümelin; Masoud Mirzaie; Friedrich A Schöndube; Joachim Richter; Hilmar Dörge
Myocardial ischemia tolerance in the newborn rat involving opioid receptors and mitochondrial K+ channels.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2006;288(3):297-303.
2005: Andreas Schmiedl; Matthias Ochs; Christian Mühlfeld; Georg Johnen; Frank Brasch
Distribution of surfactant proteins in type II pneumocytes of newborn, 14-day old, and adult rats: an immunoelectron microscopic and stereological study.
Histochemistry and cell biology 2005;124(6):465-76.
2005: Christian Mühlfeld; Dominique Singer; N Engelhardt; Joachim Richter; Andreas Schmiedl
Electron microscopy and microcalorimetry of the postnatal rat heart (Rattus norvegicus).
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2005;141(3):310-8.
2005: Oliver J Liakopoulos; Christian Mühlfeld; Marcel Koschinsky; Marlon O Coulibaly; Friedrich A Schöndube; Hilmar Dörge
Progressive loss of myocardial contractile function despite unimpaired coronary blood flow after cardiac surgery.
Basic research in cardiology 2005;100(1):75-83.
2004: Christian Mühlfeld; M Coulibaly; Hilmar Dörge; C Sellin; Oliver J Liakopoulos; C Ballat; Joachim Richter; Friedrich A Schoendube
Ultrastructure of right ventricular myocardium subjected to acute pressure load.
The Thoracic and cardiovascular surgeon 2004;52(6):328-33.
2004: Heon-Jin Lee; Wolfgang Goering; Matthias Ochs; Christian Mühlfeld; Gerd Steding; Ilona Paprotta; Wolfgang Engel; Ibrahim M Adham
Sox15 is required for skeletal muscle regeneration.
Molecular and cellular biology 2004;24(19):8428-36.