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Gerard Mulder

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Co-Publications
Name
38
Nagelkerke, Fred
17
Meerman, John
16
De Bont, Hans
12
van de Water, Bob
10
van de Velde, Cornelis
10
Pang, Sandy
9
Te Koppele, JM
8
Kuppen, Peter
8
Brussee, Johannes
7
Boogaard, Peter
7
Rothbarth, Joost
7
Vahrmeijer, Alexander
6
van Dierendonck, Jan Hein
6
Meijerman, I
6
blom, marty

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Publications

TOP 3
Burg Danny; Riepsaame Joey; Pont Chantal; Mulder Gerard; van de Water Bob
Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling.
Rothbarth J; Tollenaar R A E M; Schellens J H M; Nortier J W R; Kool L J Schultze; Kuppen P J K; Mulder G J; van de Velde C J H
Isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: recent trends and perspectives.
Rothbarth Joost; Koevoets Cindy; Tollenaar Rob A E M; Tilby Mike J; van de Velde Cornelis J H; Mulder Gerard J; Kuppen Peter J K
Immunohistochemical detection of melphalan-DNA adducts in colon cancer cells in vitro and human colorectal liver tumours in vivo.

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All Publications

2006: Burg Danny; Riepsaame Joey; Pont Chantal; Mulder Gerard; van de Water Bob
Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling.
Biochemical pharmacology 2006;71(3):268-77.
2004: Rothbarth J; Tollenaar R A E M; Schellens J H M; Nortier J W R; Kool L J Schultze; Kuppen P J K; Mulder G J; van de Velde C J H
Isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: recent trends and perspectives.
European journal of cancer (Oxford, England : 1990) 2004;40(12):1812-24.
2004: Rothbarth Joost; Koevoets Cindy; Tollenaar Rob A E M; Tilby Mike J; van de Velde Cornelis J H; Mulder Gerard J; Kuppen Peter J K
Immunohistochemical detection of melphalan-DNA adducts in colon cancer cells in vitro and human colorectal liver tumours in vivo.
Biochemical pharmacology 2004;67(9):1771-8.
2003: Hoetelmans Rob W M; Vahrmeijer Alexander L; Mulder Gerard J; van de Velde Cornelius J H; Nagelkerke J Fred; van Dierendonck Jan Hein
Bcl-2 overexpression does not prevent but retards adriamycin toxicity in CC531 colon carcinoma cells.
Chemotherapy 2003;49(6):309-15.
2003: Rothbarth J; Pijl M E J; Tollenaar R A E M; Tijl F; Ivancev G; Mulder G J; Kuppen P J K; van de Velde C J H; Schultze Kool L J
An experimental minimally invasive perfusion technique for the treatment of liver metastases.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2003;29(9):757-63.
2003: Sparidans Rolf W; Silvertand Linda; Dost Frits; Rothbarth Joost; Mulder Gerard J; Schellens Jan H M; Beijnen Jos H
Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue.
Biomedical chromatography : BMC 2003;17(7):458-64.
2003: Rothbarth Joost; Woutersen Ruud A; Sparidans Rolf W; van de Velde Cornelis J H; Mulder Gerard J
Melphalan antitumor efficacy and hepatotoxicity: the effect of variable infusion duration in the hepatic artery.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1098-103.
2003: Velthuis Jurjen H L; Stitzinger Miranda; Aalbers Remco I J M; de Bont Hans J G M; Mulder Gerard J; Kuppen Peter J K; Nagelkerke J Fred
Rat colon carcinoma cells that survived systemic immune surveillance are less sensitive to NK-cell mediated apoptosis.
Clinical & experimental metastasis 2003;20(8):713-21.
2003: Velthuis Jurjen H L; de Bont Hans J G M; Medema Jan-Paul; Kuppen Peter J K; Mulder Gerard J; Nagelkerke J Fred
Interleukin-2 activated NK cells do not use the CD95L- and TRAIL-pathways in the rapid induction of apoptosis of rat colon carcinoma CC531s cells.
Immunobiology 2003;207(2):115-27.
2002: Burg Danny; Mulder Gerard J
Glutathione conjugates and their synthetic derivatives as inhibitors of glutathione-dependent enzymes involved in cancer and drug resistance.
Drug metabolism reviews 2002;34(4):821-63.
2002: Burg Danny; Wielinga Peter; Zelcer Noam; Saeki Tohru; Mulder Gerard J; Borst Piet
Inhibition of the multidrug resistance protein 1 (MRP1) by peptidomimetic glutathione-conjugate analogs.
Molecular pharmacology 2002;62(5):1160-6.
2002: Rothbarth Joost; Sparidans Rolf W; Beijnen Jos H; Schultze-Kool Leo J; Putter Hein; van de Velde Cornelis J H; Mulder Gerard J
Reduced liver uptake of arterially infused melphalan during retrograde rat liver perfusion with unaffected liver tumor uptake.
The Journal of pharmacology and experimental therapeutics 2002;303(2):736-40.
2002: Huigsloot Merei; Tijdens Ine B; Mulder Gerard J; van de Water Bob
Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells.
The Journal of biological chemistry 2002;277(39):35869-79.
2002: Velthuis Jurjen H L; Rouschop Kasper M A; De Bont Hans J G M; Mulder Gerard J; Nagelkerke J Fred
Distinct intracellular signaling in tumor necrosis factor-related apoptosis-inducing ligand- and CD95 ligand-mediated apoptosis.
The Journal of biological chemistry 2002;277(27):24631-7.
2002: Burg Danny; Hameetman Liesbeth; Filippov Dmitri V; van der Marel Gijs A; Mulder Gerard J
Inhibition of glutathione S-transferase in rat hepatocytes by a glycine-tetrazole modified S-alkyl-GSH analogue.
Bioorganic & medicinal chemistry letters 2002;12(12):1579-82.
2002: Rothbarth Joost; Vahrmeijer Alexander L; Mulder Gerard J
Modulation of cytostatic efficacy of melphalan by glutathione: mechanisms and efficacy.
Chemico-biological interactions 2002;140(2):93-107.
2002: Schrier S Mariëtte; Florea Bogdan I; Mulder Gerard J; Nagelkerke J Fred; IJzerman Ad P
Apoptosis induced by extracellular ATP in the mouse neuroblastoma cell line N1E-115: studies on involvement of P2 receptors and adenosine.
Biochemical pharmacology 2002;63(6):1119-26.
2002: Burg Danny; Filippov Dmitri V; Hermanns Ralph; van der Marel Gijs A; van Boom Jacques H; Mulder Gerard J
Peptidomimetic glutathione analogues as novel gammaGT stable GST inhibitors.
Bioorganic & medicinal chemistry 2002;10(1):195-205.
2001: Huigsloot M; Tijdens I B; Mulder G J; van de Water B
Differential regulation of phosphatidylserine externalization and DNA fragmentation by caspases in anticancer drug-induced apoptosis of rat mammary adenocarcinoma MTLn3 cells.
Biochemical pharmacology 2001;62(8):1087-97.
2001: Blom W M; de Bont H J; Meijerman I; Kuppen P J; van Der Meulen H; Mulder G J; Nagelkerke J F
Remodeling of the actin cytoskeleton of target hepatocytes and NK cells during induction of apoptosis.
Cell motility and the cytoskeleton 2001;49(2):78-92.
2001: Schrier S M; van Tilburg E W; van der Meulen H; Ijzerman A P; Mulder G J; Nagelkerke J F
Extracellular adenosine-induced apoptosis in mouse neuroblastoma cells: studies on involvement of adenosine receptors and adenosine uptake.
Biochemical pharmacology 2001;61(4):417-25.
2000: Van Gijssel H E; Ohlson L C; Torndal U B; Mulder G J; Eriksson L C; Porsch-Hällström I; Meerman J H
Loss of nuclear p53 protein in preneoplastic rat hepatocytes is accompanied by Mdm2 and Bcl-2 overexpression and by defective response to DNA damage in vivo.
Hepatology (Baltimore, Md.) 2000;32(4 Pt 1):701-10.
2000: Boon P J; van der Boon D; Mulder G J
Cytotoxicity and biotransformation of the anticancer drug perillyl alcohol in PC12 cells and in the rat.
Toxicology and applied pharmacology 2000;167(1):55-62.
2000: van de Water B; Tijdens I B; Verbrugge A; Huigsloot M; Dihal A A; Stevens J L; Jaken S; Mulder G J
Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells.
The Journal of biological chemistry 2000;275(33):25805-13.
2000: Vahrmeijer A L; Hoetelmans R W; Mulder G J; Schutrups J; van Vlierberghe R L; van de Velde C J; van Dierendonck J H
Development of resistance to glutathione depletion-induced cell death in CC531 colon carcinoma cells: association with increased expression of bcl-2.
Biochemical pharmacology 2000;59(12):1557-62.
2000: Vahrmeijer A L; van Dierendonck J H; Keizer H J; Beijnen J H; Tollenaar R A; Pijl M E; Marinelli A; Kuppen P J; van Bockel J H; Mulder G J; van de Velde C J
Increased local cytostatic drug exposure by isolated hepatic perfusion: a phase I clinical and pharmacologic evaluation of treatment with high dose melphalan in patients with colorectal cancer confined to the liver.
British journal of cancer 2000;82(9):1539-46.
2000: van Gijssel H E; Stenius U; Mulder G J; Meerman J H
Lack of p53 protein expression in preneoplastic rat hepatocytes in vitro after exposure to N-acetoxy-acetylaminofluorene, X-rays or a proteasome inhibitor.
European journal of cancer (Oxford, England : 1990) 2000;36(1):106-12.
2000: Schier S M; Ijzerman A P; Mulder G J; Nagelkerke J F
Adenosine-induced caspase activity in N1E-115 cells.
Advances in experimental medicine and biology 2000;486():223-6.
1999: Blom W M; de Bont H J; Meijerman I; Mulder G J; Nagelkerke J F
Prevention of cycloheximide-induced apoptosis in hepatocytes by adenosine and by caspase inhibitors.
Biochemical pharmacology 1999;58(12):1891-8.
1999: Meijerman I; Blom W M; de Bont H J; Mulder G J; Nagelkerke J F
Changes of G-actin localisation in the mitotic spindle region or nucleus during mitosis and after heat shock: a histochemical study of G-actin in various cell lines with fluorescent labelled vitamin D-binding protein.
Biochimica et biophysica acta 1999;1452(1):12-24.
1999: Boon P J; Marinho H S; Oosting R; Mulder G J
Glutathione conjugation of 4-hydroxy-trans-2,3-nonenal in the rat in vivo, the isolated perfused liver and erythrocytes.
Toxicology and applied pharmacology 1999;159(3):214-23.
1999: Vahrmeijer A L; van Dierendonck J H; Schutrups J; van de Velde C J; Mulder G J
Effect of glutathione depletion on inhibition of cell cycle progression and induction of apoptosis by melphalan (L-phenylalanine mustard) in human colorectal cancer cells.
Biochemical pharmacology 1999;58(4):655-64.
1999: Meijerman I; Blom W M; de Bont H J; Mulder G J; Nagelkerke J F
Induction of apoptosis and changes in nuclear G-actin are mediated by different pathways: the effect of inhibitors of protein and RNA synthesis in isolated rat hepatocytes.
Toxicology and applied pharmacology 1999;156(1):46-55.
1999: Blom W M; De Bont H J; Meijerman I; Kuppen P J; Mulder G J; Nagelkerke J F
Interleukin-2-activated natural killer cells can induce both apoptosis and necrosis in rat hepatocytes.
Hepatology (Baltimore, Md.) 1999;29(3):785-92.
1999: Vahrmeijer A L; van Dierendonck J H; Schutrups J; van de Velde C J; Mulder G J
Potentiation of the cytostatic effect of melphalan on colorectal cancer hepatic metastases by infusion of buthionine sulfoximine (BSO) in the rat: enhanced tumor glutathione depletion by infusion of BSO in the hepatic artery.
Cancer chemotherapy and pharmacology 1999;44(2):111-6.
1998: Kruidering M; van de Water B; Zhan Y; Baelde J J; Heer E; Mulder G J; Stevens J L; Nagelkerke J F
Cisplatin effects on F-actin and matrix proteins precede renal tubular cell detachment and apoptosis in vitro.
Cell death and differentiation 1998;5(7):601-14.
1998: Ouwerkerk-Mahadevan S; Mulder G J
Inhibition of glutathione conjugation in the rat in vivo by analogues of glutathione conjugates.
Chemico-biological interactions 1998;111-112():163-76.
1998: van Gijssel H E; van Gijlswijk R P; de Haas R R; Stark C; Mulder G J; Meerman J H
Immunohistochemical visualization of wild-type p53 protein in paraffin-embedded rat liver using tyramide amplification: zonal hepatic distribution of p53 protein after N-hydroxy-2-acetylaminofluorene administration.
Carcinogenesis 1998;19(1):219-22.
1997: Meijerman I; Blom W M; de Bont H J; Mulder G J; Nagelkerke J F
Nuclear accumulation of G-actin in isolated rat hepatocytes by adenine nucleotides.
Biochemical and biophysical research communications 1997;240(3):697-700.
1997: Ouwerkerk-Mahadevan S; Tirona R G; Ripping R A; Ploemen J H; van Bladeren P J; Pang K S; van Boom J H; Mulder G J
Inhibition of glutathione conjugation by glutathione analogues in the perfused rat liver. Effect of esterification on the potency of gamma-L-glutamyl-alpha-(D-2-aminoadipyl)-N-2-heptylamine.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(10):1137-43.
1997: Mulder G J; Ouwerkerk-Mahadevan S
Modulation of glutathione conjugation in vivo: how to decrease glutathione conjugation in vivo or in intact cellular systems in vitro.
Chemico-biological interactions 1997;105(1):17-34.
1997: van Gijssel H E; Maassen C B; Mulder G J; Meerman J H
p53 protein expression by hepatocarcinogens in the rat liver and its potential role in mitoinhibition of normal hepatocytes as a mechanism of hepatic tumour promotion.
Carcinogenesis 1997;18(5):1027-33.
1997: Kruidering M; Van de Water B; de Heer E; Mulder G J; Nagelkerke J F
Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain.
The Journal of pharmacology and experimental therapeutics 1997;280(2):638-49.
1996: Vahrmeijer A L; Snel C A; Steenvoorden D P; Beijnen J H; Pang K S; Schutrups J; Tirona R; Keizer H J; van Dierendonck J H; van de Velde C J; Mulder G J
Lack of glutathione conjugation of melphalan in the isolated in situ liver perfusion in humans.
Cancer research 1996;56(20):4709-14.
1995: Van Beerendonk G J; Pearson P G; Meijer D K; Mulder G J; Nelson S D; Meerman J H
Deuterium isotope effect on the metabolism of the flame retardant tris(2,3-dibromopropyl) phosphate in the isolated perfused rat liver.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1995;28(1):111-7.
1995: Snel C A; Moons M M; Russel F G; Mulder G J
Disposition of the bromosulfophthalein-glutathione conjugate in the isolated perfused rat kidney.
The Journal of pharmacology and experimental therapeutics 1995;273(3):1300-6.
1995: Ouwerkerk-Mahadevan S; van Boom J H; Dreef-Tromp M C; Ploemen J H; Meyer D J; Mulder G J
Glutathione analogues as novel inhibitors of rat and human glutathione S-transferase isoenzymes, as well as of glutathione conjugation in isolated rat hepatocytes and in the rat in vivo.
The Biochemical journal 1995;308 ( Pt 1)():283-90.
1995: Snel C A; Pang K S; Mulder G J
Glutathione conjugation of bromosulfophthalein in relation to hepatic glutathione content in the rat in vivo and in the perfused rat liver.
Hepatology (Baltimore, Md.) 1995;21(5):1387-94.
1995: Mulders T M; Keizer H J; Breimer D D; Mulder G J
In vivo characterization and modulation of the glutathione/glutathione S-transferase system in cancer patients.
Drug metabolism reviews 1995;27(1-2):191-229.
1994: Van de Water B; Jaspers J J; Maasdam D H; Mulder G J; Nagelkerke J F
In vivo and in vitro detachment of proximal tubular cells and F-actin damage: consequences for renal function.
The American journal of physiology 1994;267(5 Pt 2):F888-99.
1994: Kruidering M; Maasdam D H; Prins F A; de Heer E; Mulder G J; Nagelkerke J F
Evaluation of nephrotoxicity in vitro using a suspension of highly purified porcine proximal tubular cells and characterization of the cells in primary culture.
Experimental nephrology 1994;2(6):324-44.
1994: van de Water B; Zoeteweij J P; de Bont H J; Mulder G J; Nagelkerke J F
Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine.
The Journal of biological chemistry 1994;269(20):14546-52.
1993: Mulders T M; van Ommen B; van Bladeren P J; Breimer D D; Mulder G J
Stereoselectivity of human liver and intestinal cytosolic fractions as well as purified human glutathione S-transferase isoenzymes towards 2-bromoisovalerylurea enantiomers.
Biochemical pharmacology 1993;46(10):1775-80.
1993: Zhao Y; Snel C A; Mulder G J; Pang K S
Localization of glutathione conjugation activities toward bromosulfophthalein in perfused rat liver. Studies with the multiple indicator dilution technique.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(6):1070-8.
1993: Snel C A; Zhao Y; Mulder G J; Pang K S
Methods for the quantitation of bromosulfophthalein and its glutathione conjugate in biological fluids.
Analytical biochemistry 1993;212(1):28-34.
1993: van de Water B; Zoetewey J P; de Bont H J; Mulder G J; Nagelkerke J F
The relationship between intracellular Ca2+ and the mitochondrial membrane potential in isolated proximal tubular cells from rat kidney exposed to the nephrotoxin 1,2-dichlorovinyl-cysteine.
Biochemical pharmacology 1993;45(11):2259-67.
1993: Polhuijs M; Gasinska I; Cherry W F; Mulder G J; Pang K S
Stereoselectivity in glutathione conjugation and amidase-catalyzed hydrolysis of the 2-bromoisovalerylurea enantiomers in the single-pass perfused rat liver.
The Journal of pharmacology and experimental therapeutics 1993;265(3):1406-12.
1993: Zoeteweij J P; van de Water B; de Bont H J; Mulder G J; Nagelkerke J F
Calcium-induced cytotoxicity in hepatocytes after exposure to extracellular ATP is dependent on inorganic phosphate. Effects on mitochondrial calcium.
The Journal of biological chemistry 1993;268(5):3384-8.
1993: Mulders T M; Venizelos V; Schoemaker R; Cohen A F; Breimer D D; Mulder G J
Characterization of glutathione conjugation in humans: stereoselectivity in plasma elimination pharmacokinetics and urinary excretion of (R)- and (S)-2-bromoisovalerylurea in healthy volunteers.
Clinical pharmacology and therapeutics 1993;53(1):49-58.
1992: Nagelkerke J F; de Bont A; de Bont H J; Tijdens I B; Mulder G J; Meerman J H
Fasting increases the susceptibility of rat hepatocytes to the cytotoxic effects of N-hydroxy-acetylaminofluorene. Effects on mitochondrial respiration and membrane potential.
Biochemical pharmacology 1992;44(12):2339-45.
1992: Zoeteweij J P; van de Water B; de Bont H J; Mulder G J; Nagelkerke J F
Involvement of intracellular Ca2+ and K+ in dissipation of the mitochondrial membrane potential and cell death induced by extracellular ATP in hepatocytes.
The Biochemical journal 1992;288 ( Pt 1)():207-13.
1992: Gilissen R A; Ringer D P; Stavenuiter H J; Mulder G J; Meerman J H
Sulfation of hydroxylamines and hydroxamic acids in liver cytosol from male and female rats and purified aryl sulfotransferase IV.
Carcinogenesis 1992;13(10):1699-703.
1992: Polhuijs M; Mulder G J; Meyer D J; Ketterer B
Stereoselective conjugation of 2-bromocarboxylic acids and their urea derivatives by rat liver glutathione transferase 12-12 and some other isoforms.
Biochemical pharmacology 1992;44(7):1249-53.
1992: Wierckx F C; Beijersbergen van Henegouwen G M; van den Broeke L T; de Vries H; Meerman J H; Mulder G J
Photoactivation of 2-nitrofluorene in vitro and in the rat in vivo. UVA-induced formation of reactive intermediates that bind covalently to RNA and protein.
Carcinogenesis 1992;13(10):1759-62.
1992: Polhuijs M; Lankhaar G; Mulder G J
Relationship between glutathione content in liver and glutathione conjugation rate in the rat in vivo. Effect of buthionine sulphoximine pretreatment on conjugation of the two 2-bromoisovalerylurea enantiomers during intravenous infusion.
The Biochemical journal 1992;285 ( Pt 2)():401-4.
1992: Muller H J; Lanens D; de Cock Buning T J; van de Vyver F L; Alderweireldt F C; Dommisse R; Spanoghe M; Mulder G J; Lugtenburg J
Noninvasive in vivo 13C-NMR spectroscopy in the rat to study the pharmacokinetics of 13C-labeled xenobiotics.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(4):507-9.
1992: Gilissen R A; Meerman J H; Mulder G J
Immobilization of solubilized UDP-glucuronosyltransferase from rat liver microsomes to Sepharose 4B.
Biochemical pharmacology 1992;43(12):2661-3.
1992: Polhuijs M; Tergau A C; Mulder G J
Chiral inversion and stereoselective glutathione conjugation of the four 2-bromo-3-methylvaleric acid stereoisomers in the rat in vivo and in vitro.
The Journal of pharmacology and experimental therapeutics 1992;260(3):1349-54.
1992: Viver M M; Nagelkerke J F; Mulder G J
Stereospecific glutathione conjugation of (R)- and (S)-2-bromoisovalerylurea in freshly isolated rat kidney proximal tubular cells.
Biochemical pharmacology 1992;43(4):902-4.
1992: Venizelos V; Irth H; Tjaden U R; van der Greef J; Breimer D D; Mulders T M; Mulder G J
Enantioselective determination of R- and S-(alpha-bromoisovaleryl)urea in plasma using high-performance liquid chromatography after solid-phase extraction.
Journal of chromatography 1992;573(2):259-64.
1992: Mulder G J
Glucuronidation and its role in regulation of biological activity of drugs.
Annual review of pharmacology and toxicology 1992;32():25-49.
1992: Lanens D; Muller H J; Van de Vyver F; de Cock-Bunning T; Spanoghe M; Van der Linden A; Mulder G J; Dommisse R; Lugtenburg J
Noninvasive in vivo 13C-NMR spectroscopy of a 13C-labeled xenobiotic in the rat.
Magnetic resonance imaging 1992;10(6):975-81.
1992: Snel C A; Mahadevan S; Polhuijs M; Mulder G J
Glutathione conjugation and pharmacokinetics of 2-bromo-3-phenylpropionic acid in vitro and in the rat in vivo.
Chirality 1992;4(7):407-14.
1991: Nagelkerke J F; van de Water B; Twiss I M; Zoetewey J P; de Bont H J; Dogterom P; Mulder G J
Role of microtubuli in secretion of very-low-density lipoprotein in isolated rat hepatocytes: early effects of thiol reagents.
Hepatology (Baltimore, Md.) 1991;14(6):1259-68.
1991: Wierckx F C; Wedzinga R; Timmers-Reker A J; Beland F A; Meerman J H; Mulder G J
DNA adduct formation in liver following the administration of [3H]2-nitrofluorene to rats in vivo.
Carcinogenesis 1991;12(11):2053-8.
1991: Noort D; Meijer E A; Visser T J; Meerman J H; Van der Marel G A; Van Boom J H; Mulder G J
Selective inhibition of glucuronidation by 2,2,2-triphenylethyl-UDP in isolated rat hepatocytes: conjugation of harmol, 3,3',5-triiodothyronine, and N-hydroxy-2-acetylaminofluorene.
Molecular pharmacology 1991;40(2):316-20.
1991: Adang A E; Moree W J; Brussee J; Mulder G J; van der Gen A
Inhibition of glutathione S-transferase 3-3 by glutathione derivatives that bind covalently to the active site.
The Biochemical journal 1991;278 ( Pt 1)():63-8.
1991: Boogaard P J; Slikkerveer A; Nagelkerke J F; Mulder G J
The role of metallothionein in the reduction of cisplatin-induced nephrotoxicity by Bi3(+)-pretreatment in the rat in vivo and in vitro. Are antioxidant properties of metallothionein more relevant than platinum binding?
Biochemical pharmacology 1991;41(3):369-75.
1991: Polhuijs M; Meijer D K; Mulder G J
The fate of diastereomeric glutathione conjugates of alpha-bromoisovalerylurea in blood in the rat in vivo and in the perfused liver. Stereoselectivity in biliary and urinary excretion.
The Journal of pharmacology and experimental therapeutics 1991;256(2):458-61.
1991: Andersson C; Mosialou E; Adang A E; Mulder G J; van der Gen A; Morgenstern R
Studies on the activity and activation of rat liver microsomal glutathione transferase with a series of glutathione analogues.
The Journal of biological chemistry 1991;266(4):2076-9.
1991: Adang A E; Brussee J; van der Gen A; Mulder G J
Inhibition of rat liver glutathione S-transferase isoenzymes by peptides stabilized against degradation by gamma-glutamyl transpeptidase.
The Journal of biological chemistry 1991;266(2):830-6.
1991: Mulder G J; te Koppele J M; Schipper C G; Snel W H; Pang K S; Polhuijs M
Stereoselectivity of glutathione conjugation in vivo, in the perfused liver and in isolated hepatocytes.
Drug metabolism reviews 1991;23(3-4):311-30.
1990: Adang A E; Brussee J; van der Gen A; Mulder G J
The glutathione-binding site in glutathione S-transferases. Investigation of the cysteinyl, glycyl and gamma-glutamyl domains.
The Biochemical journal 1990;269(1):47-54.
1990: Pang K S; Mulder G J
The effect of hepatic blood flow on formation of metabolites.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(3):270-5.
1990: Boogaard P J; Zoeteweij J P; van Berkel T J; van't Noordende J M; Mulder G J; Nagelkerke J F
Primary culture of proximal tubular cells from normal rat kidney as an in vitro model to study mechanisms of nephrotoxicity. Toxicity of nephrotoxicants at low concentrations during prolonged exposure.
Biochemical pharmacology 1990;39(8):1335-45.
1990: Noort D; Coughtrie M W; Burchell B; van der Marel G A; van Boom J H; van der Gen A; Mulder G J
Inhibition of UDP-glucuronosyltransferase activity by possible transition-state analogues in rat-liver microsomes.
European journal of biochemistry / FEBS 1990;188(2):309-12.
1990: Wierckx F C; Wedzinga R; Meerman J H; Mulder G J
Bioactivation of 2-nitrofluorene to reactive intermediates that bind covalently to DNA, RNA and protein in vitro and in vivo in the rat.
Carcinogenesis 1990;11(1):27-32.
1990: Boogaard P J; Nagelkerke J F; Mulder G J
Renal proximal tubular cells in suspension or in primary culture as in vitro models to study nephrotoxicity.
Chemico-biological interactions 1990;76(3):251-91.
1990: Boogaard P J; Mulder G J; Nagelkerke J F
Cisplatin nephrotoxicity and platinum-metallothioneins: uptake and toxicity in proximal tubular cells from rat kidney.
Contributions to nephrology 1990;83():208-12.
1989: Adang A E; Meyer D J; Brussee J; Van der Gen A; Ketterer B; Mulder G J
Interaction of rat glutathione S-transferases 7-7 and 8-8 with gamma-glutamyl- or glycyl-modified glutathione analogues.
The Biochemical journal 1989;264(3):759-64.
1989: Dogterom P; Kroese E D; Mulder G J; Nagelkerke J F
Extracellular calcium alleviates cell toxicity due to hepatotoxins that induce lipid peroxidation, but has no effect on toxins that do not cause lipid peroxidation. A study in isolated rat hepatocytes.
Biochemical pharmacology 1989;38(23):4225-30.
1989: Polhuijs M; te Koppele J M; Fockens E; Mulder G J
Glutathione conjugation of the alpha-bromoisovaleric acid enantiomers in the rat in vivo and its stereoselectivity. Pharmacokinetics of biliary and urinary excretion of the glutathione conjugate and the mercapturate.
Biochemical pharmacology 1989;38(22):3957-62.
1989: Boogaard P J; Commandeur J N; Mulder G J; Vermeulen N P; Nagelkerke J F
Toxicity of the cysteine-S-conjugates and mercapturic acids of four structurally related difluoroethylenes in isolated proximal tubular cells from rat kidney. Uptake of the conjugates and activation to toxic metabolites.
Biochemical pharmacology 1989;38(21):3731-41.
1989: Boogaard P J; Mulder G J; Nagelkerke J F
Isolated proximal tubular cells from rat kidney as an in vitro model for studies on nephrotoxicity. II. Alpha-methylglucose uptake as a sensitive parameter for mechanistic studies of acute toxicity by xenobiotics.
Toxicology and applied pharmacology 1989;101(1):144-57.
1989: Nagelkerke J F; Dogterom P; De Bont H J; Mulder G J
Prolonged high intracellular free calcium concentrations induced by ATP are not immediately cytotoxic in isolated rat hepatocytes. Changes in biochemical parameters implicated in cell toxicity.
The Biochemical journal 1989;263(2):347-53.
1989: Boogaard P J; Mulder G J; Nagelkerke J F
Isolated proximal tubular cells from rat kidney as an in vitro model for studies on nephrotoxicity. I. An improved method for preparation of proximal tubular cells and their functional characterization by alpha-methylglucose uptake.
Toxicology and applied pharmacology 1989;101(1):135-43.
1989: te Koppele J M; Schipper C; Breimer D D; Mulder G J
Stereoselectivity in the urinary excretion of the mercapturates of (R-) and (S-) alpha-bromoisovalerylurea in man.
British journal of clinical pharmacology 1989;28(2):151-4.
1989: Polhuijs M; Kuipers F; Vonk R J; Mulder G J
Stereoselectivity of glutathione conjugation: blood elimination of alpha-bromoisovalerylurea enantiomers and biliary excretion of the conjugates in unanesthetized normal or congenitally jaundiced rats.
The Journal of pharmacology and experimental therapeutics 1989;249(3):874-8.
1989: van de Poll M L; van der Hulst D A; Tates A D; Mulder G J; Meerman J H
The role of specific DNA adducts in the induction of micronuclei by N-hydroxy-2-acetylaminofluorene in rat liver in vivo.
Carcinogenesis 1989;10(4):717-22.
1989: Dogterom P; Mulder G J; Nagelkerke J F
Lipid peroxidation-dependent and -independent protein thiol modifications in isolated rat hepatocytes: differential effects of vitamin E and disulfiram.
Chemico-biological interactions 1989;71(2-3):291-306.
1988: Kroese E D; van de Poll M L; Mulder G J; Meerman J H
The role of N-sulfation in the N-hydroxy-2-acetylaminofluorene-mediated outgrowth of diethylnitrosamine-initiated hepatocytes to gamma-glutamyltranspeptidase-positive foci in male rat liver.
Carcinogenesis 1988;9(11):1953-8.
1988: Adang A E; Brussee J; Meyer D J; Coles B; Ketterer B; van der Gen A; Mulder G J
Substrate specificity of rat liver glutathione S-transferase isoenzymes for a series of glutathione analogues, modified at the gamma-glutamyl moiety.
The Biochemical journal 1988;255(2):721-4.
1988: Adang A E; Duindam A J; Brussee J; Mulder G J; van der Gen A
Synthesis and nucleophilic reactivity of a series of glutathione analogues, modified at the gamma-glutamyl moiety.
The Biochemical journal 1988;255(2):715-20.
1988: Mulder G J; Nagelkerke J F; Tijdens R B; Wijnands W J; Van der Mark E J
Inhibition of the oxidative metabolism of theophylline in isolated rat hepatocytes by the quinolone antibiotic enoxacin and its metabolite oxoenoxacin, but not by ofloxacin.
Biochemical pharmacology 1988;37(13):2565-8.
1988: Dogterom P; Nagelkerke J F; Mulder G J
Hepatotoxicity of tetrahydroaminoacridine in isolated rat hepatocytes: effect of glutathione and vitamin E.
Biochemical pharmacology 1988;37(12):2311-3.
1988: Te Koppele J M; Coles B; Ketterer B; Mulder G J
Stereoselectivity of rat liver glutathione transferase isoenzymes for alpha-bromoisovaleric acid and alpha-bromoisovalerylurea enantiomers.
The Biochemical journal 1988;252(1):137-42.
1988: te Koppele J M; van der Mark E J; Mulder G J
Liquid chromatographic determination of diastereomeric glutathione conjugates and further derivatives of alpha-bromoisovalerylurea in rat bile and urine by electrochemically generated bromine.
Journal of chromatography 1988;427(1):67-77.
1988: te Koppele J M; Esajas S W; Brussee J; van der Gen A; Mulder G J
Stereoselective glutathione conjugation of the separate alpha-bromoisovalerylurea and alpha-bromoisovaleric acid enantiomers in the rat in vivo and in rat liver subcellular fractions.
Biochemical pharmacology 1988;37(1):29-35.
1988: Dogterom P; Nagelkerke J F; van Steveninck J; Mulder G J
Inhibition of lipid peroxidation by disulfiram and diethyldithiocarbamate does not prevent hepatotoxin-induced cell death in isolated rat hepatocytes. A study with allyl alcohol, tert-butyl hydroperoxide, diethyl maleate, bromoisovalerylurea and carbon tetrachloride.
Chemico-biological interactions 1988;66(3-4):251-65.
1987: Nagelkerke J F; Tijdens R B; Schwarz E P; Winters M F; Paul L C; Mulder G J
The covalent binding of cyclosporin A to rat liver macromolecules in vivo and in vitro: the role of cytochrome P-450.
Toxicology 1987;47(3):277-84.
1987: te Koppele J M; de Lannoy I A; Pang K S; Mulder G J
Stereoselective glutathione conjugation and amidase-catalyzed hydrolysis of alpha-bromoisovalerylurea enantiomers in isolated rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 1987;243(1):349-55.
1987: Kroese E D; Tijdens R B; Mulder G J; Meerman J H
Autoradiographic studies on in vivo covalent binding of N-hydroxy-2-acetylaminofluorene in rat liver containing gamma-glutamyltranspeptidase-positive foci. The effect of the sulfation-inhibitor pentachlorophenol.
Carcinogenesis 1987;8(4):571-5.
1987: van den Goorbergh J A; de Wit H; Tijdens R B; Mulder G J; Meerman J H
Prevention by thioethers of the hepatotoxicity and covalent binding to macromolecules of N-hydroxy-2-acetylaminofluorene and its sulfate ester in rat liver in vivo and in vitro.
Carcinogenesis 1987;8(2):275-9.
1986: te Koppele J M; Dogterom P; Vermeulen N P; Meijer D K; van der Gen A; Mulder G J
alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. II. Pharmacokinetics and stereoselectivity of metabolism and excretion in vivo and in the perfused liver.
The Journal of pharmacology and experimental therapeutics 1986;239(3):905-14.
1986: te Koppele J M; van der Mark E J; Olde Boerrigter J C; Brussee J; van der Gen A; van der Greef J; Mulder G J
alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. I. (Bio-) synthesis, analysis and identification of diastereomeric glutathione conjugates and mercapturates.
The Journal of pharmacology and experimental therapeutics 1986;239(3):898-904.
1986: Meerman J H; Tijdens R B; Mulder G J
The binding of reactive metabolites of the carcinogen N-hydroxy-2-acetylaminofluorene to DNA and protein in isolated rat liver nuclei: effects of glutathione and methionine.
Journal of biochemical toxicology 1986;1(2):1-10.
1986: Pang K S; Yuen V; Fayz S; te Koppele J M; Mulder G J
Absorption and metabolism of acetaminophen by the in situ perfused rat small intestine preparation.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(1):102-11.
1984: Fayz S; Cherry W F; Dawson J R; Mulder G J; Pang K S
Inhibition of acetaminophen sulfation by 2,6-dichloro-4-nitrophenol in the perfused rat liver preparation. Lack of a compensatory increase of glucuronidation.
Drug metabolism and disposition: the biological fate of chemicals 1984;12(3):323-9.

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