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Hindrik Mulder

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Siri Malmgren; Hindrik Mulder; Cecilia L Nagorny; Marloes Dekker Nitert; Martin Ridderstråle; Peter Spégel; Lotta E Andersson; Anders P H Danielsson; Charlotte Ling
Coordinate Changes in Histone Modifications, mRNA Levels, and Metabolite Profiles in Clonal INS-1 832/13 β-Cells Accompany Functional Adaptations to Lipotoxicity.
Isabel Goehring; Hindrik Mulder; Martin D Brand; Akos A Gerencser; Sara Schmidt; David G Nicholls
Plasma membrane potential oscillations in insulin secreting Ins-1 832/13 cells do not require glycolysis and are not initiated by fluctuations in mitochondrial bioenergetics.
Isabel Göhring; Hindrik Mulder
Glutamate dehydrogenase, insulin secretion, and type 2 diabetes: a new means to protect the pancreatic β-cell?

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All Publications

2013: Siri Malmgren; Hindrik Mulder; Cecilia L Nagorny; Marloes Dekker Nitert; Martin Ridderstråle; Peter Spégel; Lotta E Andersson; Anders P H Danielsson; Charlotte Ling
Coordinate Changes in Histone Modifications, mRNA Levels, and Metabolite Profiles in Clonal INS-1 832/13 β-Cells Accompany Functional Adaptations to Lipotoxicity.
The Journal of biological chemistry 2013;288(17):11973-87.
2012: Isabel Goehring; Hindrik Mulder; Martin D Brand; Akos A Gerencser; Sara Schmidt; David G Nicholls
Plasma membrane potential oscillations in insulin secreting Ins-1 832/13 cells do not require glycolysis and are not initiated by fluctuations in mitochondrial bioenergetics.
The Journal of biological chemistry 2012;287(19):15706-17.
2012: Isabel Göhring; Hindrik Mulder
Glutamate dehydrogenase, insulin secretion, and type 2 diabetes: a new means to protect the pancreatic β-cell?
The Journal of endocrinology 2012;212(3):239-42.
2011: Hindrik Mulder
Matrix metalloproteinases: keys to healthier blood vessels in diabetes?
The Journal of endocrinology 2011;210(1):1-2.
2011: Cecilia L F Nagorny; Ramasri Sathanoori; Ulrikke Voss; Hindrik Mulder; Nils Wierup
Distribution of melatonin receptors in murine pancreatic islets.
Journal of pineal research 2011;50(4):412-7.
2011: Peter Spégel; Siri Malmgren; Vladimir V Sharoyko; Philip Newsholme; Thomas Koeck; Hindrik Mulder
Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines.
The Biochemical journal 2011;435(1):277-84.
2011: Thomas Koeck; Anders H Olsson; Marloes Dekker Nitert; Vladimir V Sharoyko; Claes Ladenvall; Olga Kotova; Erwin Reiling; Tina Rönn; Hemang Parikh; Jalal Taneera; Johan G Eriksson; Metodi D Metodiev; Nils-Göran Larsson; Alexander Balhuizen; Holger Luthman; Alena Stančáková; Johanna Kuusisto; Markku Laakso; Pernille Poulsen; Allan Vaag; Leif Groop; Valeriya Lyssenko; Hindrik Mulder; Charlotte Ling
A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.
Cell metabolism 2011;13(1):80-91.
2010: Hindrik Mulder
[Comeback for the beta cells in the pathogenesis of diabetes].
Läkartidningen 2010;107(45):2796-800.
2010: Hindrik Mulder
Is shortening of telomeres the missing link between aging and the Type 2 Diabetes epidemic?
Aging 2010;2(10):634-6.
2010: Anders P H Danielsson; Thomas Moritz; Hindrik Mulder; Peter Spégel
Development and optimization of a metabolomic method for analysis of adherent cell cultures.
Analytical biochemistry 2010;404(1):30-9.
2010: Ulrika Krus; Olga Kotova; Peter Spégel; Elna Hallgard; Vladimir V Sharoyko; Anna Vedin; Thomas Moritz; Mary C Sugden; Thomas Koeck; Hindrik Mulder
Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.
The Biochemical journal 2010;429(1):205-13.
2009: Ruben Smith; Karl Bacos; Valentina Fedele; Denis Soulet; Helena A Walz; Stefanie Obermüller; Anders Lindqvist; Maria Björkqvist; Pontus Klein; Patrik Onnerfjord; Patrik Brundin; Hindrik Mulder; Jia-Yi Li
Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion.
Human molecular genetics 2009;18(20):3942-54.
2009: Hindrik Mulder; C L F Nagorny; Valeriya Lyssenko; Leif Groop
Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene.
Diabetologia 2009;52(7):1240-9.
2009: Valeriya Lyssenko; Cecilia L F Nagorny; Michael R Erdos; Nils Wierup; Anna Jonsson; Peter Spégel; Marco Bugliani; Richa Saxena; Malin Fex; Nicolo Pulizzi; Bo Isomaa; Tiinamaija Tuomi; Peter Nilsson; Johanna Kuusisto; Jaakko Tuomilehto; Michael Boehnke; David Altshuler; Frank Sundler; Johan G Eriksson; Anne U Jackson; Markku Laakso; Piero Marchetti; Richard M Watanabe; Hindrik Mulder; Leif Groop
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.
Nature genetics 2009;41(1):82-8.
2008: Marloes Dekker Nitert; Cecilia L F Nagorny; Anna Wendt; Lena Eliasson; Hindrik Mulder
CaV1.2 rather than CaV1.3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells.
Journal of molecular endocrinology 2008;41(1):1-11.
2008: Karl Bacos; Maria Björkqvist; Asa Petersén; Lena Luts; Marion L C Maat-Schieman; Raymund A C Roos; Frank Sundler; Patrik Brundin; Hindrik Mulder; Nils Wierup
Islet beta-cell area and hormone expression are unaltered in Huntington's disease.
Histochemistry and cell biology 2008;129(5):623-9.
2008: Céline Fernandez; Ulrika Fransson; Elna Hallgard; Peter Spégel; Cecilia Holm; Morten Krogh; Kristofer Wårell; Peter James; Hindrik Mulder
Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13).
Journal of proteome research 2008;7(1):400-11.
2008: Jorien M M van der Burg; Karl Bacos; Nigel I Wood; Andreas Lindqvist; Nils Wierup; Ben Woodman; Jaclyn I Wamsteeker; Ruben Smith; Tomas Deierborg; Michael J Kuhar; Gillian P Bates; Hindrik Mulder; Charlotte Erlanson-Albertsson; A Jennifer Morton; Patrik Brundin; Asa Petersén; Maria Björkqvist
Increased metabolism in the R6/2 mouse model of Huntington's disease.
Neurobiology of disease 2008;29(1):41-51.
2007: Maria Björkqvist; Blair R Leavitt; Jörgen E Nielsen; Bernhard Landwehrmeyer; Daniel Ecker; Hindrik Mulder; Patrik Brundin; Asa Petersén
Cocaine- and amphetamine-regulated transcript is increased in Huntington disease.
Movement disorders : official journal of the Movement Disorder Society 2007;22(13):1952-4.
2007: Malin Fex; Nils Wierup; Marloes Dekker Nitert; Michael Ristow; Hindrik Mulder
Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance.
The Journal of endocrinology 2007;194(3):551-5.
2007: Malin Fex; Marloes Dekker Nitert; Nils Wierup; Frank Sundler; C Ling; Hindrik Mulder
Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.
Diabetologia 2007;50(1):74-83.
2006: Maria Björkqvist; Asa Petersén; J Nielsen; D Ecker; Hindrik Mulder; Michael R Hayden; B Landwehrmeyer; Patrik Brundin; Blair R Leavitt
Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington disease.
Clinical genetics 2006;70(1):78-9.
2006: Ulrika Fransson; A H Rosengren; Frans Schuit; Erik Renström; Hindrik Mulder
Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets.
Diabetologia 2006;49(7):1578-86.
2006: Maria Björkqvist; Asa Petersén; Karl Bacos; Jeremy Isaacs; Per Norlén; Joana Gil; Natalija Popovic; Frank Sundler; Gillian P Bates; Sarah J Tabrizi; Patrik Brundin; Hindrik Mulder
Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease.
Human molecular genetics 2006;15(10):1713-21.
2006: Nils Wierup; Maria Björkqvist; Michael J Kuhar; Hindrik Mulder; Frank Sundler
CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats.
Diabetes 2006;55(2):305-11.
2005: Eugenia Papalexi; Anna Persson; Maria Björkqvist; Asa Petersén; Ben Woodman; Gillian P Bates; Frank Sundler; Hindrik Mulder; Patrik Brundin; Natalija Popovic
Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease.
The European journal of neuroscience 2005;22(6):1541-6.
2005: Maria Björkqvist; Malin Fex; Erik Renström; Nils Wierup; Asa Petersén; Joana Gil; Karl Bacos; Natalija Popovic; Jia-Yi Li; Frank Sundler; Patrik Brundin; Hindrik Mulder
The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis.
Human molecular genetics 2005;14(5):565-74.
2005: Asa Petersén; Joana Gil; Marion L C Maat-Schieman; Maria Björkqvist; Heikki Tanila; Inês M Araújo; Ruben Smith; Natalija Popovic; Nils Wierup; Per Norlén; Jia-Yi Li; Raymund A C Roos; Frank Sundler; Hindrik Mulder; Patrik Brundin
Orexin loss in Huntington's disease.
Human molecular genetics 2005;14(1):39-47.
2004: Shumin Yang; Ulrika Fransson; Lillian Fagerhus; Lena Stenson Holst; Hans E Hohmeier; Erik Renström; Hindrik Mulder
Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13).
Molecular endocrinology (Baltimore, Md.) 2004;18(9):2312-20.
2004: Malin Fex; Charlotta S Olofsson; Ulrika Fransson; Karl Bacos; Håkan Lindvall; Maria Sörhede-Winzell; Patrik Rorsman; Cecilia Holm; Hindrik Mulder
Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact.
Endocrinology 2004;145(8):3746-53.
2004: Linda Härndahl; Nils Wierup; Sven Enerbäck; Hindrik Mulder; Vincent C Manganiello; Frank Sundler; Eva Degerman; Bo Ahrén; Lena Stenson Holst
Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology.
The Journal of biological chemistry 2004;279(15):15214-22.
2004: Nils Wierup; S Yang; R J McEvilly; Hindrik Mulder; F Sundler
Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(3):301-10.
2004: Matthias Braun; Anna Wendt; Bryndis Birnir; Jonas Broman; Lena Eliasson; Juris Galvanovskis; Jesper Gromada; Hindrik Mulder; Patrik Rorsman
Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells.
The Journal of general physiology 2004;123(3):191-204.
2004: Nils Wierup; Michael J Kuhar; Bengt-Olof Nilsson; Hindrik Mulder; Eva Ekblad; F Sundler
Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat development.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(2):169-77.
2004: Hindrik Mulder; Shumin Yang; Maria Sörhede Winzell; Cecilia Holm; Bo Ahrén
Inhibition of lipase activity and lipolysis in rat islets reduces insulin secretion.
Diabetes 2004;53(1):122-8.
2003: Hindrik Mulder; Maria Sörhede-Winzell; Juan Antonio Contreras; Malin Fex; Kristoffer Ström; Thorkil Ploug; Henrik Galbo; Peter Arner; Cecilia Lundberg; Frank Sundler; Bo Ahrén; Cecilia Holm
Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact.
The Journal of biological chemistry 2003;278(38):36380-8.
2003: Michael Ristow; Hindrik Mulder; Doreen Pomplun; Tim J Schulz; Katrin Müller-Schmehl; Anja Krause; Malin Fex; Hélène Puccio; Jörg Müller; Frank Isken; Joachim Spranger; Dirk Müller-Wieland; Mark Magnuson; Matthias Möhlig; Michel Koenig; Andreas F H Pfeiffer
Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass.
The Journal of clinical investigation 2003;112(4):527-34.
2002: Nils Wierup; H Svensson; Hindrik Mulder; Frank Sundler
The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas.
Regulatory peptides 2002;107(1-3):63-9.
2002: Per-Ola Carlsson; Ella Karlsson; Hindrik Mulder; Samuel Gebre-Medhin
Unaltered pancreatic islet blood perfusion in islet amyloid polypeptide-deficient mice.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(1):107-12.
2000: Samuel Gebre-Medhin; Charlotta S Olofsson; Hindrik Mulder
Islet amyloid polypeptide in the islets of Langerhans: friend or foe?
Diabetologia 2000;43(6):687-95.
2000: Hans E Hohmeier; Hindrik Mulder; Guoxun Chen; R Henkel-Rieger; M Prentki; Christopher B Newgard
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.
Diabetes 2000;49(3):424-30.
1999: Hindrik Mulder; H Jongsma; Y Zhang; Samuel Gebre-Medhin; Frank Sundler; Nils Danielsen
Pituitary adenylate cyclase-activating polypeptide and islet amyloid polypeptide in primary sensory neurons: functional implications from plasticity in expression on nerve injury and inflammation.
Molecular neurobiology 1999;19(3):229-53.
1999: Hindrik Mulder; Lena Stenson Holst; Håkan Svensson; Eva Degerman; Frank Sundler; Bo Ahrén; Patrik Rorsman; Cecilia Holm
Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells.
Diabetes 1999;48(1):228-32.
1998: Samuel Gebre-Medhin; Hindrik Mulder; Y Zhang; Frank Sundler; Christer Betsholtz
Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice.
Brain research. Molecular brain research 1998;63(1):180-3.
1998: Hindrik Mulder; U Myrsén-Axcrona; Samuel Gebre-Medhin; Eva Ekblad; Frank Sundler
Expression of non-classical islet hormone-like peptides during the embryonic development of the pancreas.
Microscopy research and technique 1998;43(4):313-21.
1998: Samuel Gebre-Medhin; Hindrik Mulder; Milos Pekny; Gunilla T Westermark; Jan Törnell; Per Westermark; Frank Sundler; Bo Ahrén; Christer Betsholtz
Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin).
Biochemical and biophysical research communications 1998;250(2):271-7.
1998: Lena Stenson Holst; Hindrik Mulder; Vincent C Manganiello; Frank Sundler; Bo Ahrén; Cecilia Holm; Eva Degerman
Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I.
Biochemical and biophysical research communications 1998;250(1):181-6.
1998: Y Zhang; Nils Danielsen; Frank Sundler; Hindrik Mulder
Pituitary adenylate cyclase-activating peptide is upregulated in sensory neurons by inflammation.
Neuroreport 1998;9(12):2833-6.
1997: Hindrik Mulder; Y Zhang; Nils Danielsen; Frank Sundler
Islet amyloid polypeptide and calcitonin gene-related peptide expression are upregulated in lumbar dorsal root ganglia after unilateral adjuvant-induced inflammation in the rat paw.
Brain research. Molecular brain research 1997;50(1-2):127-35.
1997: Hindrik Mulder; Y Zhang; Nils Danielsen; Frank Sundler
Islet amyloid polypeptide and calcitonin gene-related peptide expression are down-regulated in dorsal root ganglia upon sciatic nerve transection.
Brain research. Molecular brain research 1997;47(1-2):322-30.
1997: Hindrik Mulder; B Ahrén; Frank Sundler
Differential effect of insulin treatment on islet amyloid polypeptide (amylin) and insulin gene expression in streptozotocin-induced diabetes in rats.
The Journal of endocrinology 1997;152(3):495-501.
1997: Hindrik Mulder; Mats Ekelund; Eva Ekblad; Frank Sundler
Islet amyloid polypeptide in the gut and pancreas: localization, ontogeny and gut motility effects.
Peptides 1997;18(6):771-83.
1996: Lena Stenson Holst; Dominique Langin; Hindrik Mulder; H Laurell; jacques Grober; A Bergh; Harvey W Mohrenweiser; G Edgren; Cecilia Holm
Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase.
Genomics 1996;35(3):441-7.
1994: Lena Stenson Holst; A M Hoffmann; Hindrik Mulder; Frank Sundler; Cecilia Holm; A Bergh; G Fredrikson
Localization of hormone-sensitive lipase to rat Sertoli cells and its expression in developing and degenerating testes.
FEBS letters 1994;355(2):125-30.