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Hélène Muller-Steffner

Research Profile

Chemicals & Drugs

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Procedures

High Pressure Liquid Chromatography

Physiology

Calcium Signaling

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Pascal F Egea; Esther Kellenberger; Isabelle Kuhn; Hélène Muller-Steffner; Norman Oppenheimer; Céline Cakir-Kiefer; Robert M Stroud; Francis Schuber
Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.
Esther Kellenberger; Isabelle Kuhn; Francis Schuber; Hélène Muller-Steffner
Flavonoids as inhibitors of human CD38.
Isabelle Kuhn; Esther Kellenberger; Fatouma Said-Hassane; Pascal Villa; Didier Rognan; Annelise Lobstein; jacques haiech; Marcel Hibert; Francis Schuber; Hélène Muller-Steffner
Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme.

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All Publications

2012: Pascal F Egea; Esther Kellenberger; Isabelle Kuhn; Hélène Muller-Steffner; Norman Oppenheimer; Céline Cakir-Kiefer; Robert M Stroud; Francis Schuber
Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.
PloS one 2012;7(4):e34918.
2011: Esther Kellenberger; Isabelle Kuhn; Francis Schuber; Hélène Muller-Steffner
Flavonoids as inhibitors of human CD38.
Bioorganic & medicinal chemistry letters 2011;21(13):3939-42.
2010: Isabelle Kuhn; Esther Kellenberger; Fatouma Said-Hassane; Pascal Villa; Didier Rognan; Annelise Lobstein; jacques haiech; Marcel Hibert; Francis Schuber; Hélène Muller-Steffner
Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme.
Bioorganic & medicinal chemistry 2010;18(22):7900-10.
2010: Latha Ramakrishnan; Hélène Muller-Steffner; Christophe Bosc; Victor D Vacquier; Francis Schuber; Marie-Jo Moutin; Leslie Dale; Sandip Patel
A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate.
The Journal of biological chemistry 2010;285(26):19900-9.
2010: Hélène Muller-Steffner; Isabelle Kuhn; Manuela Argentini; Francis Schuber
Identification of the N-glycosylation sites on recombinant bovine CD38 expressed in Pichia pastoris: their impact on enzyme stability and catalytic activity.
Protein expression and purification 2010;70(2):151-7.
2007: Bo Zhang; Hélène Muller-Steffner; Francis Schuber; Barry V L Potter
Nicotinamide 2-fluoroadenine dinucleotide unmasks the NAD+ glycohydrolase activity of Aplysia californica adenosine 5'-diphosphate ribosyl cyclase.
Biochemistry 2007;46(13):4100-9.
2006: Isabelle Kuhn; Esther Kellenberger; Didier Rognan; Frances E Lund; Hélène Muller-Steffner; Francis Schuber
Redesign of Schistosoma mansoni NAD+ catabolizing enzyme: active site H103W mutation restores ADP-ribosyl cyclase activity.
Biochemistry 2006;45(39):11867-78.
2006: Frances E Lund; Hélène Muller-Steffner; Héctor Romero-Ramirez; Miguel E Moreno-García; Santiago Partida-Sánchez; Melissa Makris; Norman Oppenheimer; Leopoldo Santos-Argumedo; Francis Schuber
CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism.
International immunology 2006;18(7):1029-42.
2006: Claire Ceni; Nathalie Pochon; Michel Villaz; Hélène Muller-Steffner; Francis Schuber; Julie Baratier; Michel De Waard; Michel Ronjat; Marie-Jo Moutin
The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain.
The Biochemical journal 2006;395(2):417-26.
2005: Frances E Lund; Marie-Jo Moutin; Hélène Muller-Steffner; Francis Schuber
ADP-ribosyl cyclase and GDP-ribosyl cyclase activities are not always equivalent: impact on the study of the physiological role of cyclic ADP-ribose.
Analytical biochemistry 2005;346(2):336-8.
2005: Stephen Goodrich; Hélène Muller-Steffner; Ahmed Osman; Marie-Jo Moutin; Kim Kusser; Alan Roberts; David L Woodland; Troy D Randall; Esther Kellenberger; Philip T LoVerde; Francis Schuber; Frances E Lund
Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in Schistosoma mansoni.
Biochemistry 2005;44(33):11082-97.
2004: Miguel E Moreno-García; Santiago Partida-Sánchez; Julie Primack; Adriana Sumoza-Toledo; Hélène Muller-Steffner; Francis Schuber; Norman Oppenheimer; Frances E Lund; Leopoldo Santos-Argumedo
CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes.
European journal of biochemistry / FEBS 2004;271(5):1025-34.
2003: Claire Ceni; Hélène Muller-Steffner; Frances E Lund; Nathalie Pochon; Annie Schweitzer; Michel De Waard; Francis Schuber; Michel Villaz; Marie-Jo Moutin
Evidence for an intracellular ADP-ribosyl cyclase/NAD+-glycohydrolase in brain from CD38-deficient mice.
The Journal of biological chemistry 2003;278(42):40670-8.
2003: Claire Ceni; Nathalie Pochon; Virginie Brun; Hélène Muller-Steffner; Annie Andrieux; Didier Grunwald; Francis Schuber; Michel De Waard; Frances E Lund; Michel Villaz; Marie-Jo Moutin
CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain.
The Biochemical journal 2003;370(Pt 1):175-83.
2001: Céline Cakir-Kiefer; Hélène Muller-Steffner; Norman Oppenheimer; Francis Schuber
Kinetic competence of the cADP-ribose-CD38 complex as an intermediate in the CD38/NAD+ glycohydrolase-catalysed reactions: implication for CD38 signalling.
The Biochemical journal 2001;358(Pt 2):399-406.
2000: Céline Cakir-Kiefer; Hélène Muller-Steffner; Francis Schuber
Unifying mechanism for Aplysia ADP-ribosyl cyclase and CD38/NAD(+) glycohydrolases.
The Biochemical journal 2000;349(Pt 1):203-10.
2000: A Augustin; Hélène Muller-Steffner; Francis Schuber
Molecular cloning and functional expression of bovine spleen ecto-NAD+ glycohydrolase: structural identity with human CD38.
The Biochemical journal 2000;345 Pt 1():43-52.
1999: Frances E Lund; Hélène Muller-Steffner; N Yu; C D Stout; Francis Schuber; MC Howard
CD38 signaling in B lymphocytes is controlled by its ectodomain but occurs independently of enzymatically generated ADP-ribose or cyclic ADP-ribose.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2693-702.
1998: L Berruet; Hélène Muller-Steffner; Francis Schuber
Occurrence of bovine spleen CD38/NAD+glycohydrolase disulfide-linked dimers.
Biochemistry and molecular biology international 1998;46(4):847-55.
1998: DA Cockayne; Tony Muchamuel; JC Grimaldi; Hélène Muller-Steffner; Troy D Randall; Frances E Lund; R Murray; Francis Schuber; MC Howard
Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses.
Blood 1998;92(4):1324-33.
1998: V Berthelier; J M Tixier; Hélène Muller-Steffner; Francis Schuber; Philippe Deterre
Human CD38 is an authentic NAD(P)+ glycohydrolase.
The Biochemical journal 1998;330 ( Pt 3)():1383-90.
1997: Hélène Muller-Steffner; A Augustin; Francis Schuber
Involvement of bovine spleen NAD+ glycohydrolase in the metabolism of cyclic ADP-ribose-mechanism of the cyclization reaction.
Advances in experimental medicine and biology 1997;419():399-409.
1996: Hélène Muller-Steffner; J Slama; Francis Schuber
Photodependent inhibition of bovine spleen NAD+ glycohydrolase by 8-azido carbocyclic analogs of NAD+.
Biochemical and biophysical research communications 1996;228(1):128-33.
1996: Hélène Muller-Steffner; A Augustin; Francis Schuber
Mechanism of cyclization of pyridine nucleotides by bovine spleen NAD+ glycohydrolase.
The Journal of biological chemistry 1996;271(39):23967-72.
1994: Hélène Muller-Steffner; M Muzard; N Oppenheimer; Francis Schuber
Mechanistic implications of cyclic ADP-ribose hydrolysis and methanolysis catalyzed by calf spleen NAD+glycohydrolase.
Biochemical and biophysical research communications 1994;204(3):1279-85.
1993: Hélène Muller-Steffner; I Schenherr-Gusse; C Tarnus; Francis Schuber
Calf spleen NAD+ glycohydrolase: solubilization, purification, and properties of the intact form of the enzyme.
Archives of biochemistry and biophysics 1993;304(1):154-62.
1992: Hélène Muller-Steffner; O Malver; L Hosie; N J Oppenheimer; Francis Schuber
Slow-binding inhibition of NAD+ glycohydrolase by arabino analogues of beta-NAD.
The Journal of biological chemistry 1992;267(14):9606-11.