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Christa Müller

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Benjamin F Seibt; Farag F Sherbiny; Dominik Thimm; Sonja Hinz; Anke C Schiedel; Christa E Müller
The second extracellular loop of GPCRs determines subtype-selectivity and controls efficacy as evidenced by loop exchange study at A2 adenosine receptors.
Dominik Thimm; Anke C Schiedel; Farag F Sherbiny; Daniela C G Bertarelli; Sonja Hinz; Katharina Hochheiser; Astrid Maass; Christa E Müller
Ligand-specific binding and activation of the human adenosine A(2B) receptor.
Sang-Yong Lee; Sébastien A. Lévesque; Jean Sévigny; Christa E Müller
A highly sensitive capillary electrophoresis method using p-nitrophenyl 5'-thymidine monophosphate as a substrate for the monitoring of nucleotide pyrophosphatase/phosphodiesterase activities.

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2013: Benjamin F Seibt; Farag F Sherbiny; Dominik Thimm; Sonja Hinz; Anke C Schiedel; Christa E Müller
The second extracellular loop of GPCRs determines subtype-selectivity and controls efficacy as evidenced by loop exchange study at A2 adenosine receptors.
Biochemical pharmacology 2013;85(9):1317-29.
2013: Dominik Thimm; Anke C Schiedel; Farag F Sherbiny; Daniela C G Bertarelli; Sonja Hinz; Katharina Hochheiser; Astrid Maass; Christa E Müller
Ligand-specific binding and activation of the human adenosine A(2B) receptor.
Biochemistry 2013;52(4):726-40.
2012: Sang-Yong Lee; Sébastien A. Lévesque; Jean Sévigny; Christa E Müller
A highly sensitive capillary electrophoresis method using p-nitrophenyl 5'-thymidine monophosphate as a substrate for the monitoring of nucleotide pyrophosphatase/phosphodiesterase activities.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;911():162-9.
2012: Victor Hernandez-Olmos; Aliaa Abdelrahman; Ali El-Tayeb; Diana Freudendahl; Stephanie Weinhausen; Christa E Müller
N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists.
Journal of medicinal chemistry 2012;55(22):9576-88.
2012: Jessica L Santerre; Younis Baqi; Lyndsey E Collins-Praino; Merce Correa; Rotem Kovner; Chelsea E Leser; Laura Lopez Cruz; Christa E Müller; Eric J Nunes; Patrick A Randall; John D Salamone
The novel adenosine A(2A) antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions.
Pharmacology, biochemistry, and behavior 2012;102(4):477-87.
2012: Viktor Rempel; Nicole Volz; Wolfgang Wenzel; Martin Nieger; Stefan Bräse; Sonja Hinz; Tadeusz Karcz; Irene Meliciani; Christa E Müller
7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists.
Journal of medicinal chemistry 2012;55(18):7967-77.
2012: Christa E Müller; Anke C Schiedel; Younis Baqi
Allosteric modulators of rhodopsin-like G protein-coupled receptors: opportunities in drug development.
Pharmacology & therapeutics 2012;135(3):292-315.
2012: Simone Hildenbrand; Susanne Schoch; Rainer Surges; Marec von Lehe; Christa E Müller
Tritium-labeled brivaracetam with high specific activity: preparation, characterization and application in human brain samples.
ChemMedChem 2012;7(8):1369-74.
2012: Michael Gütschow; Jamshed Iqbal; Mohamad Wessam Alnouri; Jürgen Gäb; Minka Paskaleva; Miriam Schlenk; Silvia Scolari; Christa E Müller
Benzothiazinones: a novel class of adenosine receptor antagonists structurally unrelated to xanthine and adenine derivatives.
Journal of medicinal chemistry 2012;55(7):3331-41.
2012: Nikolay T Tzvetkov; Harald Euler; Christa E Müller
Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives: A new drug-like heterocyclic scaffold.
Beilstein journal of organic chemistry 2012;8():1584-93.
2012: Patrick A Randall; V Kiran Vemuri; Younis Baqi; Mercè Correa; Laura López Cruz; Alex Makriyannis; Christa E Müller; Eric J Nunes; Marta Pardo; John D Salamone
Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences.
PloS one 2012;7(10):e47934.
2012: Younis Baqi; Christa E Müller
Convergent synthesis of the potent P2Y receptor antagonist MG 50-3-1 based on a regioselective Ullmann coupling reaction.
Molecules (Basel, Switzerland) 2012;17(3):2599-615.
2011: Anna Drabczyńska; Jadwiga Handzlik; Tadeusz Karcz; Janina Karolak-Wojciechowska; Meryem Köse; Kamil Kuder; Christa E Müller; Minka Paskaleva; Anke C Schiedel; Olga Yuzlenko; Katarzyna Kieć-Kononowicz
Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.
European journal of medicinal chemistry 2011;46(9):3590-607.
2011: Lyndsey E Collins; Daniel J Galtieri; Chelsea E Leser; Christa E Müller; Nicholas E Paul; Samantha J Podurgiel; Shams F Abbas; Younis Baqi; James J Chrobak; John D Salamone
Oral tremor induced by galantamine in rats: a model of the parkinsonian side effects of cholinomimetics used to treat Alzheimer's disease.
Pharmacology, biochemistry, and behavior 2011;99(3):414-22.
2011: Anke C Schiedel; Farag Sherbiny; Dominik Thimm; Thomas Borrmann; Sonja Hinz; Astrid Maass; Christa E Müller
The four cysteine residues in the second extracellular loop of the human adenosine A2B receptor: role in ligand binding and receptor function.
Biochemical pharmacology 2011;82(4):389-99.
2011: Jamshed Iqbal; Christa E Müller
High-sensitivity capillary electrophoresis method for monitoring purine nucleoside phosphorylase and adenosine deaminase reactions by a reversed electrode polarity switching mode.
Journal of chromatography. A 2011;1218(29):4764-71.
2011: Patrick A Randall; Thomas N Sager; Colin M Stopper; Younis Baqi; Andrew M Farrar; Jörg Hockemeyer; Simone L Janniere; Christa E Müller; Eric J Nunes; John D Salamone
Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists.
Psychopharmacology 2011;216(2):173-86.
2011: Christa E Müller; Kenneth Alan Jacobson
Recent developments in adenosine receptor ligands and their potential as novel drugs.
Biochimica et biophysica acta 2011;1808(5):1290-308.
2011: Ali El-Tayeb; Robert A Nicholas; Aidong Qi; Christa E Müller
Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors.
Journal of medicinal chemistry 2011;54(8):2878-90.
2011: Anne Pick; Henrik Müller; Ralf Mayer; Britta Haenisch; Ilza K Pajeva; Mathias Weigt; Heinz Bönisch; Christa E Müller; Michael Wiese
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
Bioorganic & medicinal chemistry 2011;19(6):2090-102.
2011: Younis Baqi; Ralf Hausmann; Jürgen Rettinger; Christiane Rosefort; Günther Schmalzing; Christa E Müller
Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor.
Journal of medicinal chemistry 2011;54(3):817-30.
2011: Anna Drabczyńska; Malgorzata Zygmunt; Jacek Sapa; Barbara Filipek; Christa E Müller; Katarzyna Kieć-Kononowicz
Antiparkinsonian effects of novel adenosine A(2A) receptor antagonists.
Archiv der Pharmazie 2011;344(1):20-7.
2011: Christa E Müller; Kenneth Alan Jacobson
Xanthines as adenosine receptor antagonists.
Handbook of experimental pharmacology 2011;(200):151-99.
2011: Mariana Pereira; Andrew M Farrar; Jörg Hockemeyer; Christa E Müller; John D Salamone; Joan I Morrell
Effect of the adenosine A2A receptor antagonist MSX-3 on motivational disruptions of maternal behavior induced by dopamine antagonism in the early postpartum rat.
Psychopharmacology 2011;213(1):69-79.
2010: Lyndsey E Collins; Daniel J Galtieri; Patricia Collins; Shawnet K Jones; Russell G Port; Nicholas E Paul; Jörg Hockemeyer; Christa E Müller; John D Salamone
Interactions between adenosine and dopamine receptor antagonists with different selectivity profiles: Effects on locomotor activity.
Behavioural brain research 2010;211(2):148-55.
2010: Sandra Dettmann; Katrin Szymanowitz; Anja Wellner; Anke Schiedel; Christa E Müller; Ronald Gust
2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation.
Bioorganic & medicinal chemistry 2010;18(14):4905-16.
2010: Younis Baqi; Christa E Müller
Synthesis of alkyl- and aryl-amino-substituted anthraquinone derivatives by microwave-assisted copper(0)-catalyzed Ullmann coupling reactions.
Nature protocols 2010;5(5):945-53.
2010: Andrew M Farrar; K N Segovia; P A Randall; E J Nunes; L E Collins; C M Stopper; R G Port; Jörg Hockemeyer; Christa E Müller; Mercè Correa; John D Salamone
Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors.
Neuroscience 2010;166(4):1056-67.
2010: Gajanan S Inamdar; Swapnil G Yerande; Ali El-Tayeb; Wenjin Li; Gajanan Inamdar; Kamala K Vasu; Vasudevan Sudarsanam; Christa E Müller
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.
Bioorganic & medicinal chemistry 2010;18(6):2195-203.
2010: Younis Baqi; Sang-Yong Lee; Jamshed Iqbal; Peter Ripphausen; Anne Lehr; Anja B Scheiff; Herbert Zimmermann; Jürgen Bajorath; Christa E Müller
Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold.
Journal of medicinal chemistry 2010;53(5):2076-86.
2010: Lyndsey E Collins; Daniel J Galtieri; Lise T Brennum; Thomas N Sager; Jörg Hockemeyer; Christa E Müller; James R Hinman; James J Chrobak; John D Salamone
Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX.
Pharmacology, biochemistry, and behavior 2010;94(4):561-9.
2010: Jamshed Iqbal; Aileen F Knowles; Christa E Müller
Development of a microbioreactor with ecto-nucleoside triphosphate diphosphohydrolase 2 (NTPDase2) immobilized on a polyacrylamide-coated capillary at the outlet.
Journal of chromatography. A 2010;1217(4):600-4.
2010: Giana P Cognato; Paula M.G. Agostinho; Jörg Hockemeyer; Christa E Müller; Diogo O Souza; Rodrigo A Cunha
Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
Journal of neurochemistry 2010;112(2):453-62.
2009: Ali El-Tayeb; Jamshed Iqbal; Andrea Behrenswerth; Michael Romio; Marion Schneider; Herbert Zimmermann; Jürgen Schrader; Christa E Müller
Nucleoside-5'-monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5'-nucleotidase.
Journal of medicinal chemistry 2009;52(23):7669-77.
2009: Christa E Müller
Prodrug approaches for enhancing the bioavailability of drugs with low solubility.
Chemistry & biodiversity 2009;6(11):2071-83.
2009: Farag F Sherbiny; Anke C Schiedel; Astrid Maass; Christa E Müller
Homology modelling of the human adenosine A2B receptor based on X-ray structures of bovine rhodopsin, the beta2-adrenergic receptor and the human adenosine A2A receptor.
Journal of computer-aided molecular design 2009;23(11):807-28.
2009: Kristina Hoffmann; Younis Baqi; María Sol Morena; Markus Glänzel; Christa E Müller; Ivar von Kügelgen
Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor.
The Journal of pharmacology and experimental therapeutics 2009;331(2):648-55.
2009: Thomas Borrmann; Aliaa Abdelrahman; Rosaria Volpini; Catia Lambertucci; Edgars Alksnis; Simone Gorzalka; Melanie Knospe; Anke C Schiedel; Gloria Cristalli; Christa E Müller
Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family.
Journal of medicinal chemistry 2009;52(19):5974-89.
2009: Carina Klein; Anja Grahnert; Aliaa Abdelrahman; Christa E Müller; Sunna Hauschildt
Extracellular NAD(+) induces a rise in [Ca(2+)](i) in activated human monocytes via engagement of P2Y(1) and P2Y(11) receptors.
Cell calcium 2009;46(4):263-72.
2009: Carsten Linnemann; Frank A Schildberg; Anna Schurich; Linda Diehl; Silke I Hegenbarth; Elmar Endl; Svenja Lacher; Christa E Müller; Jürgen Frey; Luca Simeoni; Burkhart Schraven; Dirk Stabenow; Percy A Knolle
Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling.
Immunology 2009;128(1 Suppl):e728-37.
2009: Elzbieta Pekala; Joachim C Burbiel; Christa E Müller
Preparation of enantiopure (R)-hydroxy metabolite of denbufylline using immobilized Lactobacillus kefiri DSM 20587 as a catalyst.
Chirality 2009;21(8):713-8.
2009: Roland Sauer; Ali El-Tayeb; Marko Kaulich; Christa E Müller
Synthesis of uracil nucleotide analogs with a modified, acyclic ribose moiety as P2Y(2) receptor antagonists.
Bioorganic & medicinal chemistry 2009;17(14):5071-9.
2009: Thomas Borrmann; Sonja Hinz; Daniela C G Bertarelli; Wenjin Li; Nicole C Florin; Anja B Scheiff; Christa E Müller
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.
Journal of medicinal chemistry 2009;52(13):3994-4006.
2009: Younis Baqi; Kerstin Atzler; Meryem Köse; Markus Glänzel; Christa E Müller
High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.
Journal of medicinal chemistry 2009;52(12):3784-93.
2009: Petra Hillmann; Geun-Yung Ko; Andreas Spinrath; Alexandra Raulf; Ivar von Kügelgen; Samuel C Wolff; Robert A Nicholas; Evi Kostenis; Hans-Dieter Höltje; Christa E Müller
Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling.
Journal of medicinal chemistry 2009;52(9):2762-75.
2009: Allison M Mott; Eric J Nunes; Lyndsey E Collins; Russell G Port; Kelly S Sink; Jörg Hockemeyer; Christa E Müller; John D Salamone
The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure.
Psychopharmacology 2009;204(1):103-12.
2009: Andrea Behrenswerth; Nicole Volz; Jakob Toräng; Sonja Hinz; Stefan Bräse; Christa E Müller
Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists.
Bioorganic & medicinal chemistry 2009;17(7):2842-51.
2009: Lila T Worden; Mona Shahriari; Andrew M Farrar; Kelly S Sink; Jörg Hockemeyer; Christa E Müller; John D Salamone
The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonists.
Psychopharmacology 2009;203(3):489-99.
2009: Younis Baqi; Stefanie Weyler; Jamshed Iqbal; Herbert Zimmermann; Christa E Müller
Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases).
Purinergic signalling 2009;5(1):91-106.
2008: Jamshed Iqbal; Sébastien A. Lévesque; Jean Sévigny; Christa E Müller
A highly sensitive CE-UV method with dynamic coating of silica-fused capillaries for monitoring of nucleotide pyrophosphatase/phosphodiesterase reactions.
Electrophoresis 2008;29(17):3685-93.
2008: Geanne M A Cunha; Paula Canas; Carolina S Melo; Jörg Hockemeyer; Christa E Müller; Catarina R Oliveira; Rodrigo A Cunha
Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801.
Experimental neurology 2008;210(2):776-81.
2008: Andras Bilkei-Gorzo; Osama M Abo-Salem; Alaa M Hayallah; Kerstin Michel; Christa E Müller; Andreas Zimmer
Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia.
Naunyn-Schmiedeberg's archives of pharmacology 2008;377(1):65-76.
2008: Petra Hillmann; Meryem Köse; Kristina Söhl; Christa E Müller
Ammonium-induced calcium mobilization in 1321N1 astrocytoma cells.
Toxicology and applied pharmacology 2008;227(1):36-47.
2008: Jamshed Iqbal; David Jirovsky; Sang-Yong Lee; Herbert Zimmermann; Christa E Müller
Capillary electrophoresis-based nanoscale assays for monitoring ecto-5'-nucleotidase activity and inhibition in preparations of recombinant enzyme and melanoma cell membranes.
Analytical biochemistry 2008;373(1):129-40.
2008: Ivar von Kügelgen; Anke C Schiedel; Kristina Hoffmann; Bernt B A Alsdorf; Aliaa Abdelrahman; Christa E Müller
Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain.
Molecular pharmacology 2008;73(2):469-77.
2008: John D Salamone; Keita Ishiwari; Adrienne J Betz; Andrew M Farrar; Susana Mingote; Laura Font; Jörg Hockemeyer; Christa E Müller; Mercè Correa
Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism.
Parkinsonism & related disorders 2008;14 Suppl 2():S130-4.
2008: Karl Vollmann; Ramatullah Qurishi; Jörg Hockemeyer; Christa E Müller
Synthesis and properties of a new water-soluble prodrug of the adenosine A 2A receptor antagonist MSX-2.
Molecules (Basel, Switzerland) 2008;13(2):348-59.
2008: Stefanie Weyler; Younis Baqi; Petra Hillmann; Marko Kaulich; Andrea M Hunder; Ingrid A Müller; Christa E Müller
Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists.
Bioorganic & medicinal chemistry letters 2008;18(1):223-7.
2007: Dirk Bokemeyer; Darius Panek; Masashi Kitahara; James M Trzaskos; Christa E Müller; Jörg Hockemeyer; Uta Kunter; Peter Boor; Jürgen Floege; Herbert kramer; Tammo Ostendorf
The map kinase ERK regulates renal activity of cyclin-dependent kinase 2 in experimental glomerulonephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(12):3431-41.
2007: Anna Drabczyńska; Christa E Müller; Anke Schiedel; Britta Schumacher; Janina Karolak-Wojciechowska; Andrzej Fruziński; Weronika Zobnina; Olga Yuzlenko; Katarzyna Kieć-Kononowicz
Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: structure-activity relationships as adenosine A(1) and A(2A) receptor ligands.
Bioorganic & medicinal chemistry 2007;15(22):6956-74.
2007: Anke C Schiedel; Heiko Meyer; Bernt B A Alsdorf; Simone Gorzalka; Hannelore Brüssel; Christa E Müller
[(3)H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions.
Purinergic signalling 2007;3(4):347-58.
2007: Younis Baqi; Christa E Müller
Catalyst-free microwave-assisted amination of 2-chloro-5-nitrobenzoic acid.
The Journal of organic chemistry 2007;72(15):5908-11.
2007: Anna Drabczyńska; Christa E Müller; Janina Karolak-Wojciechowska; Britta Schumacher; Anke Schiedel; Olga Yuzlenko; Katarzyna Kieć-Kononowicz
N9-benzyl-substituted 1,3-dimethyl- and 1,3-dipropyl-pyrimido[2,1-f]purinediones: synthesis and structure-activity relationships at adenosine A1 and A2A receptors.
Bioorganic & medicinal chemistry 2007;15(14):5003-17.
2007: Andrew M Farrar; Mariana Pereira; Francisco Velasco; Jörg Hockemeyer; Christa E Müller; John D Salamone
Adenosine A(2A) receptor antagonism reverses the effects of dopamine receptor antagonism on instrumental output and effort-related choice in the rat: implications for studies of psychomotor slowing.
Psychopharmacology 2007;191(3):579-86.
2007: Younis Baqi; Christa E Müller
Rapid and efficient microwave-assisted copper(0)-catalyzed ullmann coupling reaction: general access to anilinoanthraquinone derivatives.
Organic letters 2007;9(7):1271-4.
2007: Tadeusz Librowski; Monika Kubacka; Manuela Meusel; Silvia Scolari; Christa E Müller; Michael Gütschow
Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides.
European journal of pharmacology 2007;559(2-3):138-49.
2007: Jamshed Iqbal; Leonardo Scapozza; Gerd Folkers; Christa E Müller
Development and validation of a capillary electrophoresis method for the characterization of herpes simplex virus type 1 (HSV-1) thymidine kinase substrates and inhibitors.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;846(1-2):281-90.
2007: Svenja K Lacher; Ralf Mayer; Kathrin Sichardt; Karen Nieber; Christa E Müller
Interaction of valerian extracts of different polarity with adenosine receptors: identification of isovaltrate as an inverse agonist at A1 receptors.
Biochemical pharmacology 2007;73(2):248-58.
2007: Christa E Müller; Sergi Ferré
Blocking striatal adenosine A2A receptors: a new strategy for basal ganglia disorders.
Recent patents on CNS drug discovery 2007;2(1):1-21.
2006: Christa E Müller; Jamshed Iqbal; Younis Baqi; Herbert Zimmermann; Anita Röllich; Holger Stephan
Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(23):5943-7.
2006: H Phuoc Le; Christa E Müller
Rapid microwave-assisted fluorination yielding novel 5'-deoxy-5'-fluorouridine derivatives.
Bioorganic & medicinal chemistry letters 2006;16(23):6139-42.
2006: Ali El-Tayeb; Aidong Qi; Christa E Müller
Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors.
Journal of medicinal chemistry 2006;49(24):7076-87.
2006: Anna Drabczyńska; Christa E Müller; Svenja K Lacher; Britta Schumacher; Janina Karolak-Wojciechowska; Antony Nasal; Piotr Kawczak; Olga Yuzlenko; Elzbieta Pekala; Katarzyna Kieć-Kononowicz
Synthesis and biological activity of tricyclic aryloimidazo-, pyrimido-, and diazepinopurinediones.
Bioorganic & medicinal chemistry 2006;14(21):7258-81.
2006: Daniela C G Bertarelli; Martina Diekmann; Alaa M Hayallah; Dorothee Rüsing; Jamshed Iqbal; Birgit Preiss; Eugen J Verspohl; Christa E Müller
Characterization of human and rodent native and recombinant adenosine A(2B) receptors by radioligand binding studies.
Purinergic signalling 2006;2(3):559-71.
2006: Stefanie Weyler; Friederike Fülle; Martina Diekmann; Britta Schumacher; Sonja Hinz; Karl-Norbert Klotz; Christa E Müller
Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones.
ChemMedChem 2006;1(8):891-902.
2006: Luo Yan; Daniela C G Bertarelli; Alaa M Hayallah; Heiko Meyer; Karl-Norbert Klotz; Christa E Müller
A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists.
Journal of medicinal chemistry 2006;49(14):4384-91.
2006: Jamshed Iqbal; Joachim C Burbiel; Christa E Müller
Development of off-line and on-line capillary electrophoresis methods for the screening and characterization of adenosine kinase inhibitors and substrates.
Electrophoresis 2006;27(12):2505-17.
2006: Stephane Massip; Jean Guillon; Daniela C G Bertarelli; Jean-Jacques Bosc; Jean-Michel Léger; Svenja K Lacher; Cécile Bontemps; Thibaut Dupont; Christa E Müller; Christian Jarry
Synthesis and preliminary evaluation of new 1- and 3-[1-(2-hydroxy-3-phenoxypropyl)]xanthines from 2-amino-2-oxazolines as potential A1 and A2A adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2006;14(8):2697-719.
2006: Jacek Bulicz; Daniela C G Bertarelli; Dieter Baumert; Friederike Fülle; Christa E Müller; Dieter Heber
Synthesis and pharmacology of pyrido[2,3-d]pyrimidinediones bearing polar substituents as adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2006;14(8):2837-49.
2006: Joachim C Burbiel; Jörg Hockemeyer; Christa E Müller
Microwave-assisted ring closure reactions: synthesis of 8-substituted xanthine derivatives and related pyrimido- and diazepinopurinediones.
Beilstein journal of organic chemistry 2006;2():20.
2006: Rhalid Akkari; Joachim C Burbiel; Jörg Hockemeyer; Christa E Müller
Recent progress in the development of adenosine receptor ligands as antiinflammatory drugs.
Current topics in medicinal chemistry 2006;6(13):1375-99.
2006: Andreas Brunschweiger; Christa E Müller
P2 receptors activated by uracil nucleotides--an update.
Current medicinal chemistry 2006;13(3):289-312.
2005: Ali El-Tayeb; Kerstin J Griessmeier; Christa E Müller
Synthesis and preliminary evaluation of [3H]PSB-0413, a selective antagonist radioligand for platelet P2Y12 receptors.
Bioorganic & medicinal chemistry letters 2005;15(24):5450-2.
2005: Jamshed Iqbal; Petra Vollmayer; Norbert Braun; Herbert Zimmermann; Christa E Müller
A capillary electrophoresis method for the characterization of ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) and the analysis of inhibitors by in-capillary enzymatic microreaction.
Purinergic signalling 2005;1(4):349-58.
2005: Marcello Solinas; Sergi Ferré; Katerina Antoniou; DAVIDE QUARTA; Zuzana Justinova; Jörg Hockemeyer; Lara A Pappas; Pavan N Segal; Carrie Wertheim; Christa E Müller; Steven R Goldberg
Involvement of adenosine A1 receptors in the discriminative-stimulus effects of caffeine in rats.
Psychopharmacology 2005;179(3):576-86.
2005: Janez Ilas; Slavko Pecar; Jörg Hockemeyer; Harald Euler; Armin Kirfel; Christa E Müller
Development of spin-labeled probes for adenosine receptors.
Journal of medicinal chemistry 2005;48(6):2108-14.
2005: Charles W Schindler; Marzena Karcz-Kubicha; Eric B Thorndike; Christa E Müller; Srihari R Tella; Sergi Ferré; Steven R Goldberg
Role of central and peripheral adenosine receptors in the cardiovascular responses to intraperitoneal injections of adenosine A1 and A2A subtype receptor agonists.
British journal of pharmacology 2005;144(5):642-50.
2005: Simone Gorzalka; Sauro Vittori; Rosaria Volpini; Gloria Cristalli; Ivar von Kügelgen; Christa E Müller
Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.
Molecular pharmacology 2005;67(3):955-64.
2004: Anna Drabczyńska; Christa E Müller; Britta Schumacher; Sonja Hinz; Janina Karolak-Wojciechowska; Barbara Michalak; Elzbieta Pekala; Katarzyna Kieć-Kononowicz
Tricyclic oxazolo[2,3-f]purinediones: potency as adenosine receptor ligands and anticonvulsants.
Bioorganic & medicinal chemistry 2004;12(18):4895-908.
2004: Jörg Hockemeyer; Joachim C Burbiel; Christa E Müller
Multigram-scale syntheses, stability, and photoreactions of A2A adenosine receptor antagonists with 8-styrylxanthine structure: potential drugs for Parkinson's disease.
The Journal of organic chemistry 2004;69(10):3308-18.
2004: Stefan Kehraus; Simone Gorzalka; Christian Hallmen; Jamshed Iqbal; Christa E Müller; Anthony D Wright; Michael Wiese; Gabriele M König
Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative.
Journal of medicinal chemistry 2004;47(9):2243-55.
2004: Katarzyna Kieć-Kononowicz; Janina Karolak-Wojciechowska; Barbara Michalak; Elzbieta Pekala; Britta Schumacher; Christa E Müller
Imidazo[2,1-b]thiazepines: synthesis, structure and evaluation of benzodiazepine receptor binding.
European journal of medicinal chemistry 2004;39(3):205-18.
2004: Luo Yan; Christa E Müller
Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.
Journal of medicinal chemistry 2004;47(4):1031-43.
2004: Charles W Schindler; Marzena Karcz-Kubicha; Eric B Thorndike; Christa E Müller; Srihari R Tella; Steven R Goldberg; Sergi Ferré
Lack of adenosine A1 and dopamine D2 receptor-mediated modulation of the cardiovascular effects of the adenosine A2A receptor agonist CGS 21680.
European journal of pharmacology 2004;484(2-3):269-75.
2004: Osama M Abo-Salem; Alaa M Hayallah; Andras Bilkei-Gorzo; Barbara Filipek; Andreas Zimmer; Christa E Müller
Antinociceptive effects of novel A2B adenosine receptor antagonists.
The Journal of pharmacology and experimental therapeutics 2004;308(1):358-66.
2003: Luo Yan; Joachim C Burbiel; Astrid Maass; Christa E Müller
Adenosine receptor agonists: from basic medicinal chemistry to clinical development.
Expert opinion on emerging drugs 2003;8(2):537-76.
2003: Marzena Karcz-Kubicha; DAVIDE QUARTA; Bruce Hope; Katerina Antoniou; Christa E Müller; Marisela Morales; Charles W Schindler; Steven R Goldberg; Sergi Ferré
Enabling role of adenosine A1 receptors in adenosine A2A receptor-mediated striatal expression of c-fos.
The European journal of neuroscience 2003;18(2):296-302.
2003: Marzena Karcz-Kubicha; Katerina Antoniou; Anton Terasmaa; DAVIDE QUARTA; Marcello Solinas; Zuzana Justinova; Antonella Pezzola; Rosaria Reggio; Christa E Müller; Kjell Fuxe; Steven R Goldberg; Patrizia Popoli; Sergi Ferré
Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(7):1281-91.
2003: Marko Kaulich; Ramatullah Qurishi; Christa E Müller
Extracellular metabolism of nucleotides in neuroblastoma x glioma NG108-15 cells determined by capillary electrophoresis.
Cellular and molecular neurobiology 2003;23(3):349-64.
2003: Anna Drabczyńska; Britta Schumacher; Christa E Müller; Janina Karolak-Wojciechowska; Barbara Michalak; Elzbieta Pekala; Katarzyna Kieć-Kononowicz
Impact of the aryl substituent kind and distance from pyrimido[2,1-f]purindiones on the adenosine receptor selectivity and antagonistic properties.
European journal of medicinal chemistry 2003;38(4):397-402.
2003: Vita Ozola; Mark Thorand; Martina Diekmann; Ramatullah Qurishi; Britta Schumacher; Kenneth Alan Jacobson; Christa E Müller
2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors.
Bioorganic & medicinal chemistry 2003;11(3):347-56.
2003: Christa E Müller
Medicinal chemistry of adenosine A3 receptor ligands.
Current topics in medicinal chemistry 2003;3(4):445-62.
2002: Britta Schumacher; Silke Scholle; Josef Hölzl; Nasser Khudeir; Sonja Hess; Christa E Müller
Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors.
Journal of natural products 2002;65(10):1479-85.
2002: Christa E Müller; Britta Schumacher; Axel Brattström; Ehab A Abourashed; Uwe Koetter
Interactions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptors.
Life sciences 2002;71(16):1939-49.
2002: Christa E Müller; Mark Thorand; Ramatullah Qurishi; Martina Diekmann; Kenneth Alan Jacobson; William L Padgett; John W Daly
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.
Journal of medicinal chemistry 2002;45(16):3440-50.
2002: Ramatullah Qurishi; Marko Kaulich; Christa E Müller
Fast, efficient capillary electrophoresis method for measuring nucleotide degradation and metabolism.
Journal of chromatography. A 2002;952(1-2):275-81.
2002: Alaa M Hayallah; Jesús Sandoval-Ramírez; Ulrike Reith; Ulrike Schobert; Birgit Preiss; Britta Schumacher; John W Daly; Christa E Müller
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.
Journal of medicinal chemistry 2002;45(7):1500-10.
2002: Christa E Müller; Martina Diekmann; Mark Thorand; Vita Ozola
[(3)H]8-Ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one ([(3)H]PSB-11), a novel high-affinity antagonist radioligand for human A(3) adenosine receptors.
Bioorganic & medicinal chemistry letters 2002;12(3):501-3.
2002: Christa E Müller
P2-pyrimidinergic receptors and their ligands.
Current pharmaceutical design 2002;8(26):2353-69.
2001: Christa E Müller
A(3) adenosine receptor antagonists.
Mini reviews in medicinal chemistry 2001;1(4):417-27.
2001: K Kieć-Kononowicz; Janina Karolak-Wojciechowska; Christa E Müller; Britta Schumacher; Elzbieta Pekala; E Szymańska
Imidazo-thiazine, -diazinone and -diazepinone derivatives. Synthesis, structure and benzodiazepine receptor binding.
European journal of medicinal chemistry 2001;36(5):407-19.
2001: Christa E Müller
A1 adenosine receptors and their ligands: overview and recent developments.
Farmaco (Società chimica italiana : 1989) 2001;56(1-2):77-80.
2000: Sonja Hess; Christa E Müller; W Frobenius; Ulrike Reith; Karl-Norbert Klotz; Kurt Eger
7-Deazaadenines bearing polar substituents: structure-activity relationships of new A(1) and A(3) adenosine receptor antagonists.
Journal of medicinal chemistry 2000;43(24):4636-46.
2000: R Sauer; J Maurinsh; Ulrike Reith; Friederike Fülle; Karl-Norbert Klotz; Christa E Müller
Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists.
Journal of medicinal chemistry 2000;43(3):440-8.
2000: Christa E Müller; J Maurinsh; R Sauer
Binding of [3H]MSX-2 (3-(3-hydroxypropyl)-7-methyl-8-(m-methoxystyryl)-1-propargylxanthine) to rat striatal membranes--a new, selective antagonist radioligand for A(2A) adenosine receptors.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(4):259-65.
1998: Christa E Müller; Jesús Sandoval-Ramírez; Ulrike Schobert; U Geis; W Frobenius; Karl-Norbert Klotz
8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists.
Bioorganic & medicinal chemistry 1998;6(6):707-19.
1998: Barbara Matuszczak; Elzbieta Pekala; Christa E Müller
1-substituted 4-[chloropyrazolyl][1,2,4]triazolo[4,3-a]quinoxalines: synthesis and structure-activity relationships of a new class of benzodiazepine and adenosine receptor ligands.
Archiv der Pharmazie 1998;331(5):163-9.
1998: C Eder; Peter Schupp; Peter Proksch; Victor Wray; Klaus G Steube; Christa E Müller; W Frobenius; Markus Herderich; RW van Soest
Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp.
Journal of natural products 1998;61(2):301-5.
1997: Christa E Müller; U Geis; J Hipp; Ulrike Schobert; W Frobenius; M Pawłowski; F Suzuki; Jesús Sandoval-Ramírez
Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists.
Journal of medicinal chemistry 1997;40(26):4396-405.
1997: Christa E Müller; R Sauer; U Geis; W Frobenius; P Talik; M Pawlowski
Aza-analogs of 8-styrylxanthines as A2A-adenosine receptor antagonists.
Archiv der Pharmazie 1997;330(6):181-9.
1996: Christa E Müller; U Geis; B Grahner; W Lanzner; Kurt Eger
Chiral pyrrolo[2,3-d]pyrimidine and pyrimido[4,5-b]indole derivatives: structure-activity relationships of potent, highly stereoselective A1-adenosine receptor antagonists.
Journal of medicinal chemistry 1996;39(13):2482-91.
1996: Christa E Müller
[Epibatidine--a nicotine-related, analgesic alkaloid from poison-dart frogs].
Pharmazie in unserer Zeit 1996;25(2):85-92.
1995: U Geis; B Grahner; M Pawłowski; A Drabczynska; M Gorczyca; Christa E Müller
Tricyclic theophylline derivatives with high water-solubility: structure-activity relationships at adenosine receptors, phosphodiesterases, and benzodiazepine binding sites.
Die Pharmazie 1995;50(5):333-6.
1994: Christa E Müller; B Grahner; D Heber
Amino-substituted 1,8-naphthyridines and pyrido[2,3-d]pyrimidines: new compounds with affinity for A1- and A2-adenosine receptors.
Die Pharmazie 1994;49(12):878-80.
1994: B Grahner; S Winiwarter; W Lanzner; Christa E Müller
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.
Journal of medicinal chemistry 1994;37(10):1526-34.
1991: John W Daly; I Hide; Christa E Müller; M Shamim
Caffeine analogs: structure-activity relationships at adenosine receptors.
Pharmacology 1991;42(6):309-21.
1990: Christa E Müller; I Hide; John W Daly; K Rothenhäusler; Kurt Eger
7-Deaza-2-phenyladenines: structure-activity relationships of potent A1 selective adenosine receptor antagonists.
Journal of medicinal chemistry 1990;33(10):2822-8.
1989: Christa E Müller; G Folkers
[Adenosine receptor ligands--drugs of the future?].
Pharmazie in unserer Zeit 1989;18(3):65-75.
1989: G Folkers; G Junginger; Christa E Müller; U Schloz; Kurt Eger
[Synthesis of computer graphic calculated high-anti-fixed pyrimidine nucleoside analogs with potential virostatic and antineoplastic action].
Archiv der Pharmazie 1989;322(2):119-23.
1989: Peter Daniel; J Holzschuh; Christa E Müller; H J Roth; Peter A Berg
Inhibition of phytohemagglutinine-induced T lymphocyte proliferation by 6-(octadecyldithio)purine, a novel liposomal prodrug of 6-mercaptopurine.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1989;13():179-82.