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Frank Müller

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Agatha Stegemann; Adriana del Rey; Beate Eckes; Bernd L Fiebich; Sergei A Grando; Alexander Heinick; Thomas A Luger; Frank U Müller; Karin Scharffetter-Kochanek; Jan S Schulte; Anca Sindrilaru; Markus Böhm
Tropisetron suppresses collagen synthesis in skin fibroblasts via α7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model.
M A Tekook; E Zlotkin; Larissa Fabritz; P Kirchhof; S König; Frank U Müller; W Schmitz; T Tal; Uwe Kirchhefer
Gene construction, expression and functional testing of an inotropic peptide from the venom of the black scorpion Hottentotta judaicus.
Dana Kučerová; Marek Mát'uš; Frank U Müller; Joachim Neumann; Wilhelm Schmitz; Hideo A Baba; Peter Bokník; Larissa Fabritz; Alexander Heinick; Uwe Kirchhefer
Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes.

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2013: Agatha Stegemann; Adriana del Rey; Beate Eckes; Bernd L Fiebich; Sergei A Grando; Alexander Heinick; Thomas A Luger; Frank U Müller; Karin Scharffetter-Kochanek; Jan S Schulte; Anca Sindrilaru; Markus Böhm
Tropisetron suppresses collagen synthesis in skin fibroblasts via α7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model.
Arthritis and rheumatism 2013;65(3):792-804.
2012: M A Tekook; E Zlotkin; Larissa Fabritz; P Kirchhof; S König; Frank U Müller; W Schmitz; T Tal; Uwe Kirchhefer
Gene construction, expression and functional testing of an inotropic peptide from the venom of the black scorpion Hottentotta judaicus.
Toxicon : official journal of the International Society on Toxinology 2012;60(8):1415-27.
2012: Dana Kučerová; Marek Mát'uš; Frank U Müller; Joachim Neumann; Wilhelm Schmitz; Hideo A Baba; Peter Bokník; Larissa Fabritz; Alexander Heinick; Uwe Kirchhefer
Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes.
American journal of physiology. Heart and circulatory physiology 2012;302(10):H2008-17.
2012: J S Schulte; Matthias D Seidl; C Freese; F Nunes; Wilhelm Schmitz; M Schneider; Frank U Müller
CREB critically regulates action potential shape and duration in the adult mouse ventricle.
American journal of physiology. Heart and circulatory physiology 2012;302(10):H1998-2007.
2012: Peter Milberg; Frank U Müller; Sigrid Nikol; Dennis Noble; Nani Osada; Christian Pott; Trong Hung Quang; Matthias Ruhe; Jörg Stypmann; Martin Fink; Gerrit Frommeyer; Rainer Klocke; Toshio Matsuda; Akemichi Baba; Günter Breithardt; Lars Eckardt
Acute inhibition of the Na(+)/Ca(2+) exchanger reduces proarrhythmia in an experimental model of chronic heart failure.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(4):570-8.
2012: Christian Pott; Matthias Ruhe; Wilhelm Schmitz; Jan S Schulte; Adam Muszynski; Kenneth D Philipson; N Bögeholz; Günter Breithardt; Lars Eckardt; Larissa Fabritz; Joshua I Goldhaber; Paulus Kirchhof; Peter Milberg; Gerold Mönnig; Frank U Müller
Proarrhythmia in a non-failing murine model of cardiac-specific Na+/Ca 2+ exchanger overexpression: whole heart and cellular mechanisms.
Basic research in cardiology 2012;107(2):247.
2011: Paul J M Wijnker; Peter Boknik; Cris dos Remedios; Ulrich Gergs; Frank U Müller; Joachim Neumann; Wilhelm Schmitz; Jürgen R Sindermann; Ger J M Stienen; Jolanda van der Velden; Uwe Kirchhefer
Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium.
Journal of muscle research and cell motility 2011;32(3):221-33.
2010: Carsten Müller-Tidow; Hans-Ulrich Klein; Antje Hascher; Fabienne Isken; Lara Tickenbrock; Nils Thoennissen; Shuchi Agrawal-Singh; Petra Tschanter; Christine Disselhoff; Yipeng Wang; Anke Becker; Christian Thiede; Gerhard Ehninger; Udo zur Stadt; Steffen Koschmieder; Matthias Seidl; Frank U Müller; Wilhelm Schmitz; Peter Schlenke; Michael McClelland; Wolfgang E Berdel; Martin Dugas; Hubert Serve
Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia.
Blood 2010;116(18):3564-71.
2010: Uwe Kirchhefer; Diana Wehrmeister; Alex V Postma; Gottfried Pohlentz; Michael Mormann; Dana Kucerova; Frank U Müller; Wilhelm Schmitz; Eric Schulze-Bahr; Arthur A Wilde; Joachim Neumann
The human CASQ2 mutation K206N is associated with hyperglycosylation and altered cellular calcium handling.
Journal of molecular and cellular cardiology 2010;49(1):95-105.
2009: Peter Boknik; S Grote-Wessels; G Barteska; M Jiang; Frank U Müller; Wilhelm Schmitz; Joachim Neumann; L Birnbaumer
Genetic disruption of G proteins, G(i2)alpha or G(o)alpha, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium.
British journal of pharmacology 2009;158(6):1557-64.
2009: Martina Ahlmann; Georg Varga; Karsten Sturm; Ralph Lippe; Konrad Benedyk; Dorothee Viemann; Thomas E Scholzen; Jan Ehrchen; Frank U Müller; Matthias Seidl; Marek Matus; George C Tsokos; Johannes Roth; Klaus Tenbrock
The cyclic AMP response element modulator {alpha} suppresses CD86 expression and APC function.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4167-74.
2009: Geertje Lewin; Marek Matus; Abhijit Basu; Karin Frebel; Sebastian Pius Rohsbach; Andrej Safronenko; Matthias Dodo Seidl; Frank Stümpel; Igor B Buchwalow; Simone Koenig; Stefan Engelhardt; Martin J Lohse; Wilhelm Schmitz; Frank U Müller
Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction.
Circulation 2009;119(1):79-88.
2008: Stephanie Grote-Wessels; Hideo A Baba; Peter Boknik; Ali El-Armouche; Larissa Fabritz; Hans-Jörg Gillmann; Dana Kucerova; Marek Matus; Frank U Müller; Joachim Neumann; Martina Schmitz; Frank Stümpel; Gregor Theilmeier; Jeremias Wohlschlaeger; Wilhelm Schmitz; Uwe Kirchhefer
Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload.
Cardiovascular research 2008;79(3):464-71.
2007: Uwe Kirchhefer; Jan Klimas; Hideo A Baba; Igor B Buchwalow; Larissa Fabritz; Marion Hüls; Marek Matus; Frank U Müller; Wilhelm Schmitz; Joachim Neumann
Triadin is a critical determinant of cellular Ca cycling and contractility in the heart.
American journal of physiology. Heart and circulatory physiology 2007;293(5):H3165-74.
2007: Ulrich Gergs; Tobias Berndt; Jan Buskase; Larry R Jones; Uwe Kirchhefer; Frank U Müller; Klaus-Dieter Schlüter; Wilhelm Schmitz; Joachim Neumann
On the role of junctin in cardiac Ca2+ handling, contractility, and heart failure.
American journal of physiology. Heart and circulatory physiology 2007;293(1):H728-34.
2007: Marek Matus; Geertje Lewin; Frank Stümpel; Igor B Buchwalow; Michael D Schneider; Günther Schütz; Wilhelm Schmitz; Frank U Müller
Cardiomyocyte-specific inactivation of transcription factor CREB in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(8):1884-92.
2007: Karla Punkt; Stefan Schering; M Fritzsche; Gerhard Asmussen; Evgeny A Minin; Vera E Samoilova; Frank U Müller; Wilhelm Schmitz; Martin Hasselblatt; W Paulus; Ursula Müller-Werdan; Jan Slezak; Gabriele Koehler; Werner Boecker; Igor B Buchwalow
Fibre-related nitric oxide synthase (NOS) in Duchenne muscular dystrophy.
Acta histochemica 2007;109(3):228-36.
2006: Igor B Buchwalow; Evgeny A Minin; Frank U Müller; Geertje Lewin; Vera E Samoilova; Wilhelm Schmitz; Maren Wellner; Martin Hasselblatt; Karla Punkt; Ursula Müller-Werdan; Uta Demus; Jan Slezak; Gabriele Koehler; Werner Boecker
Nitric oxide synthase in muscular dystrophies: a re-evaluation.
Acta neuropathologica 2006;111(6):579-88.
2005: Frank U Müller; Geertje Lewin; Hideo A Baba; Peter Bokník; Larissa Fabritz; Uwe Kirchhefer; Paulus Kirchhof; Karin Loser; Marek Matus; Joachim Neumann; Burkhard Riemann; Wilhelm Schmitz
Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic mice.
The Journal of biological chemistry 2005;280(8):6906-14.
2004: Frank U Müller; Karin Loser; U Kleideiter; J Neumann; C von Wallbrunn; T Dobner; H-H Scheld; Heike Bantel; Ingo H Engels; Klaus Schulze-Osthoff; Wilhelm Schmitz
Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes.
Cell death and differentiation 2004;11(5):485-93.
2003: Frank U Müller; Geertje Lewin; Marek Matus; Joachim Neumann; Burkhard Riemann; Joachim Wistuba; Günther Schütz; Wilhelm Schmitz
Impaired cardiac contraction and relaxation and decreased expression of sarcoplasmic Ca2+-ATPase in mice lacking the CREM gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):103-5.
2002: Frank U Müller
[Can a hydergine therapy lead to damage of the coronary vessels?].
Deutsche medizinische Wochenschrift (1946) 2002;127(25-26):1401.
2002: Frank U Müller; Uwe Kirchhefer; Frank Begrow; Uta Reinke; Joachim Neumann; Wilhelm Schmitz
Junctional sarcoplasmic reticulum transmembrane proteins in the heart.
Basic research in cardiology 2002;97 Suppl 1():I52-5.
2001: Frank U Müller; Peter Bokník; Jörg Knapp; Bettina Linck; Hartmut Lüss; Joachim Neumann; Wilhelm Schmitz
Activation and inactivation of cAMP-response element-mediated gene transcription in cardiac myocytes.
Cardiovascular research 2001;52(1):95-102.
2001: Bettina Linck; Peter Boknik; Jörg Knapp; K Kikuchi; Hartmut Lüss; Frank U Müller; K Nomoto; Joachim Neumann; Wilhelm Schmitz
Functional properties of the rat phosphatase 1alpha promoter.
Molecular and cellular biochemistry 2001;223(1-2):123-9.
2001: Peter Bokník; S Khorchidi; G S Bodor; S Huke; Jörg Knapp; Bettina Linck; Hartmut Lüss; Frank U Müller; Wilhelm Schmitz; Joachim Neumann
Role of protein phosphatases in regulation of cardiac inotropy and relaxation.
American journal of physiology. Heart and circulatory physiology 2001;280(2):H786-94.
2000: Hartmut Lüss; O Klein-Wiele; Peter Bokník; Stefan Herzig; Jörg Knapp; Bettina Linck; Frank U Müller; Hans H Scheld; C Schmid; Wilhelm Schmitz; Joachim Neumann
Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.
Journal of molecular and cellular cardiology 2000;32(12):2349-59.
2000: Frank U Müller; Joachim Neumann; Wilhelm Schmitz
Transcriptional regulation by cAMP in the heart.
Molecular and cellular biochemistry 2000;212(1-2):11-7.
2000: Peter Bokník; M Fockenbrock; Stefan Herzig; Jörg Knapp; Bettina Linck; Hartmut Lüss; Frank U Müller; T Müller; Wilhelm Schmitz; F Schröder; Joachim Neumann
Protein phosphatase activity is increased in a rat model of long-term beta-adrenergic stimulation.
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(3):222-31.
2000: Bettina Linck; Peter Bokník; S Huke; Uwe Kirchhefer; Jörg Knapp; Hartmut Lüss; Frank U Müller; Joachim Neumann; Z Tanriseven; U Vahlensieck; Hideo A Baba; Larry R Jones; K D Philipson; Wilhelm Schmitz
Functional properties of transgenic mouse hearts overexpressing both calsequestrin and the Na(+)-Ca(2+) exchanger.
The Journal of pharmacology and experimental therapeutics 2000;294(2):648-57.
2000: Jörg Knapp; Peter Bokník; Bettina Linck; Hartmut Lüss; Frank U Müller; L Petertönjes; Wilhelm Schmitz; Joachim Neumann
Cantharidin enhances norepinephrine-induced vasoconstriction in an endothelium-dependent fashion.
The Journal of pharmacology and experimental therapeutics 2000;294(2):620-6.
2000: Hartmut Lüss; Andreas Meissner; Norbert Rolf; Hugo Van Aken; Peter Bokník; Uwe Kirchhefer; Jörg Knapp; S Läer; Bettina Linck; I Lüss; Frank U Müller; Joachim Neumann; Wilhelm Schmitz
Biochemical mechanism(s) of stunning in conscious dogs.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H176-84.
2000: Peter Bokník; U Vahlensieck; S Huke; Jörg Knapp; Bettina Linck; Hartmut Lüss; Frank U Müller; Joachim Neumann; Wilhelm Schmitz
On the cardiac contractile, electrophysiological and biochemical effects of endothall, a protein phosphatase inhibitor.
Pharmacology 2000;61(1):43-50.
2000: Andreas Meissner; I Lüss; Norbert Rolf; Peter Boknik; Uwe Kirchhefer; V Kehm; Jörg Knapp; Bettina Linck; Hartmut Lüss; Frank U Müller; Thomas Weber; Wilhelm Schmitz; Hugo Van Aken; Joachim Neumann
The early response genes c-jun and HSP-70 are induced in regional cardiac stunning in conscious mammals.
The Journal of thoracic and cardiovascular surgery 2000;119(4 Pt 1):820-5.
1999: Joachim Neumann; U Vahlensieck; Peter Boknik; Bettina Linck; Hartmut Lüss; Frank U Müller; G Paul Matherne; Wilhelm Schmitz
Functional studies in atrium overexpressing A1-adenosine receptors.
British journal of pharmacology 1999;128(7):1623-9.
1999: Jörg Knapp; Peter Bokník; MC Deng; S Huke; I Lüss; O Klein-Wiele; Bettina Linck; Hartmut Lüss; Frank U Müller; Peter Nacke; Hans H Scheld; Wilhelm Schmitz; U Vahlensieck; Joachim Neumann
On the contractile function of protein phosphatases in isolated human coronary arteries.
Naunyn-Schmiedeberg's archives of pharmacology 1999;360(4):464-72.
1999: Jörg Knapp; Peter Bokník; Bettina Linck; S Läer; Frank U Müller; Joachim Neumann; U Vahlensieck; Hartmut Schlüter; Walter Zidek; Wilhelm Schmitz
Inositol-1,4,5-trisphosphate increase by diadenosine tetraphosphate in preparations from failing human myocardium.
Naunyn-Schmiedeberg's archives of pharmacology 1999;360(3):354-7.
1999: Peter Bokník; C Unkel; Uwe Kirchhefer; U Kleideiter; O Klein-Wiele; Jörg Knapp; Bettina Linck; Hartmut Lüss; Frank U Müller; Wilhelm Schmitz; U Vahlensieck; N Zimmermann; Larry R Jones; Joachim Neumann
Regional expression of phospholamban in the human heart.
Cardiovascular research 1999;43(1):67-76.
1999: I Lüss; Peter Boknik; Larry R Jones; Uwe Kirchhefer; Jörg Knapp; Bettina Linck; Hartmut Lüss; Andreas Meissner; Frank U Müller; Wilhelm Schmitz; U Vahlensieck; Joachim Neumann
Expression of cardiac calcium regulatory proteins in atrium v ventricle in different species.
Journal of molecular and cellular cardiology 1999;31(6):1299-314.
1999: Jörg Knapp; Peter Bokník; I Lüss; S Huke; Bettina Linck; Hartmut Lüss; Frank U Müller; T Müller; Peter Nacke; Thomas Noll; H M Piper; Wilhelm Schmitz; U Vahlensieck; Joachim Neumann
The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability.
The Journal of pharmacology and experimental therapeutics 1999;289(3):1480-6.
1999: Jörg Knapp; Peter Bokník; H G Gumbinger; Bettina Linck; Hartmut Lüss; Frank U Müller; Wilhelm Schmitz; U Vahlensieck; Joachim Neumann
Quantitation of clobazam in human plasma using high-performance liquid chromatography.
Journal of chromatographic science 1999;37(5):145-9.
1999: Joachim Neumann; Andreas Meissner; Peter Bokník; I Gombosová; Jörg Knapp; Hartmut Lüss; Frank U Müller; Hartmut Schlüter; Walter Zidek; Norbert Rolf; Hugo Van Aken; U Vahlensieck; Wilhelm Schmitz
Inotropic effects of diadenosine tetraphosphate in isolated canine cardiac preparations.
Journal of cardiovascular pharmacology 1999;33(1):151-6.
1998: Jörg Knapp; Peter Bokník; S Huke; I Gombosová; Bettina Linck; Hartmut Lüss; Frank U Müller; T Müller; Peter Nacke; Wilhelm Schmitz; U Vahlensieck; Joachim Neumann
Contractility and inhibition of protein phosphatases by cantharidin.
General pharmacology 1998;31(5):729-33.
1998: Frank U Müller; Peter Bokník; Jörg Knapp; Joachim Neumann; U Vahlensieck; E Oetjen; Hans H Scheld; Wilhelm Schmitz
Identification and expression of a novel isoform of cAMP response element modulator in the human heart.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(12):1191-9.
1998: Bettina Linck; Peter Bokník; Hideo A Baba; Thomas Eschenhagen; Uwe Haverkamp; Elmar Jäckel; Larry R Jones; Uwe Kirchhefer; Jörg Knapp; S Läer; Frank U Müller; Wilhelm Schmitz; H Scholz; A Syska; U Vahlensieck; Joachim Neumann
Long-term beta adrenoceptor-mediated alteration in contractility and expression of phospholamban and sarcoplasmic reticulum Ca(++)-ATPase in mammalian ventricle.
The Journal of pharmacology and experimental therapeutics 1998;286(1):531-8.
1998: Hartmut Lüss; Peter Bokník; G Heusch; Frank U Müller; Joachim Neumann; Wilhelm Schmitz; R Schulz
Expression of calcium regulatory proteins in short-term hibernation and stunning in the in situ porcine heart.
Cardiovascular research 1998;37(3):606-17.
1998: S Läer; F Remmers; H Scholz; B Stein; Frank U Müller; Joachim Neumann
Receptor mechanisms involved in the 5-HT-induced inotropic action in the rat isolated atrium.
British journal of pharmacology 1998;123(6):1182-8.
1998: Jörg Knapp; Peter Bokník; S Huke; Hartmut Lüss; Frank U Müller; T Müller; Peter Nacke; Wilhelm Schmitz; U Vahlensieck; Joachim Neumann
The mechanism of action of cantharidin in smooth muscle.
British journal of pharmacology 1998;123(5):911-9.
1997: Frank U Müller; Peter Bokník; Jörg Knapp; Hartmut Lüss; Joachim Neumann; U Vahlensieck; Markus Böhm; MC Deng; Hans H Scheld; Wilhelm Schmitz
Quantification of the cAMP response element binding protein in ventricular nuclear protein from failing and nonfailing human hearts.
Biochemical and biophysical research communications 1997;236(2):351-4.
1997: Jörg Knapp; Peter Bokník; Bettina Linck; Hartmut Lüss; Frank U Müller; Peter Nacke; Joachim Neumann; U Vahlensieck; Wilhelm Schmitz
The effect of the protein phosphatases inhibitor cantharidin on beta-adrenoceptor-mediated vasorelaxation.
British journal of pharmacology 1997;120(3):421-8.
1996: U Vahlensieck; Peter Bokník; Jörg Knapp; Bettina Linck; Frank U Müller; J Neumann; Stefan Herzig; Hartmut Schlüter; Walter Zidek; M C Deng; Hans H Scheld; W Schmitz
Negative chronotropic and inotropic effects exerted by diadenosine hexaphosphate (AP6A) via A1-adenosine receptors.
British journal of pharmacology 1996;119(5):835-44.
1996: Bettina Linck; Peter Boknik; Jörg Knapp; Frank U Müller; J Neumann; W Schmitz; U Vahlensieck
Effects of cantharidin on force of contraction and phosphatase activity in nonfailing and failing human hearts.
British journal of pharmacology 1996;119(3):545-50.
1996: W Schmitz; Peter Boknik; Bettina Linck; Frank U Müller
Adrenergic and muscarinic receptor regulation and therapeutic implications in heart failure.
Molecular and cellular biochemistry 1996;157(1-2):251-8.
1996: Bettina Linck; Peter Bokník; Thomas Eschenhagen; Frank U Müller; J Neumann; M Nose; Larry R Jones; W Schmitz; H Scholz
Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts.
Cardiovascular research 1996;31(4):625-32.
1995: Frank U Müller; Peter Bokník; A Horst; Jörg Knapp; Bettina Linck; W Schmitz; U Vahlensieck; A Walter
In vivo isoproterenol treatment leads to downregulation of the mRNA encoding the cAMP response element binding protein in the rat heart.
Biochemical and biophysical research communications 1995;215(3):1043-9.
1995: Frank U Müller; Peter Bokník; A Horst; Jörg Knapp; Bettina Linck; W Schmitz; U Vahlensieck; M Böhm; M C Deng; Hans H Scheld
cAMP response element binding protein is expressed and phosphorylated in the human heart.
Circulation 1995;92(8):2041-3.
1994: Frank U Müller; Thomas Eschenhagen; A Reidemeister; W Schmitz; H Scholz
In vivo beta-adrenergic stimulation leads to biphasic regulation of Gi alpha-2 gene transcriptional activity in rat heart.
Journal of molecular and cellular cardiology 1994;26(7):869-75.
1993: Frank U Müller; K R Boheler; Thomas Eschenhagen; W Schmitz; H Scholz
Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart.
Circulation research 1993;72(3):696-700.
1992: W Schmitz; Thomas Eschenhagen; U Mende; Frank U Müller; J Neumann; H Scholz
Phosphodiesterase inhibition and positive inotropy in failing human myocardium.
Basic research in cardiology 1992;87 Suppl 1():65-71.
1991: W Schmitz; Thomas Eschenhagen; U Mende; Frank U Müller; H Scholz
The role of alpha 1-adrenergic and muscarinic receptors in cardiac function.
European heart journal 1991;12 Suppl F():83-7.