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John Mullins

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Bart F J Heijnen; Ben J A Janssen; John J Mullins; Jelly Nelissen; Carine J Peutz-Kootstra; Casper G Schalkwijk; Jan W Cohen Tervaert; Gregorio E Fazzi; Helma van Essen; Harry A J Struijker Boudier
Irreversible renal damage after transient renin-angiotensin system stimulation: involvement of an AT1-receptor mediated immune response.
Eilidh Craigie; Louise C Evans; John J Mullins; Matthew A Bailey
Failure to downregulate the epithelial sodium channel causes salt sensitivity in Hsd11b2 heterozygote mice.
Louise C Evans; Maurits A Jansen; Christopher J Kenyon; Dawn E Livingstone; John J Mullins; James W Dear; Matthew A Bailey
A urine-concentrating defect in 11β-hydroxysteroid dehydrogenase type 2 null mice.

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All Publications

2013: Bart F J Heijnen; Ben J A Janssen; John J Mullins; Jelly Nelissen; Carine J Peutz-Kootstra; Casper G Schalkwijk; Jan W Cohen Tervaert; Gregorio E Fazzi; Helma van Essen; Harry A J Struijker Boudier
Irreversible renal damage after transient renin-angiotensin system stimulation: involvement of an AT1-receptor mediated immune response.
PloS one 2013;8(2):e57815.
2012: Eilidh Craigie; Louise C Evans; John J Mullins; Matthew A Bailey
Failure to downregulate the epithelial sodium channel causes salt sensitivity in Hsd11b2 heterozygote mice.
Hypertension 2012;60(3):684-90.
2012: Louise C Evans; Maurits A Jansen; Christopher J Kenyon; Dawn E Livingstone; John J Mullins; James W Dear; Matthew A Bailey
A urine-concentrating defect in 11β-hydroxysteroid dehydrogenase type 2 null mice.
American journal of physiology. Renal physiology 2012;303(4):F494-502.
2012: Barbara S Peters; Jörg Peters; Rami Dornaika; Stefan Hadlich; Norbert Hosten; John J Mullins; Rainer Rettig
Regression of cardiac hypertrophy in cyp1a1ren-2 transgenic rats.
Journal of magnetic resonance imaging : JMRI 2012;36(2):373-8.
2012: Sabrina Semprini; Michael R H White; Amanda Patist; Adriano G Rossi; Raheela Awais; Julian R E Davis; Ian Dransfield; Karen Featherstone; Claire V Harper; Anne V McNamara; Alan S McNeilly; Judith R McNeilly; John J Mullins
Peritonitis activates transcription of the human prolactin locus in myeloid cells in a humanized transgenic rat model.
Endocrinology 2012;153(6):2724-34.
2012: Bryan R Conway; Donald R Dunbar; Jeremy Hughes; Jonathan R Manning; Matthew A Bailey; Christopher O Bellamy; Jillian Rennie; John J Mullins
Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy.
Journal of the American Society of Nephrology : JASN 2012;23(3):405-11.
2012: Ali Ashek; Christopher O C Bellamy; Peter W Flatman; Anthony J Harmar; Christopher J Kenyon; Robert I Menzies; John J Mullins; Linda J Mullins; Matthew A Bailey
Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat.
PloS one 2012;7(4):e36311.
2011: Bart F J Heijnen; Ben J A Janssen; John J Mullins; Carine J Peutz-Kootstra; Harry A J Struijker Boudier
Transient renin-angiotensin system stimulation in an early stage of life causes sustained hypertension in rats.
Journal of hypertension 2011;29(12):2369-80.
2011: Karen Featherstone; Claire V Harper; Anne McNamara; Alan S McNeilly; Judith McNeilly; John J Mullins; Sabrina Semprini; David G Spiller; Michael R H White; Julian R E Davis
Pulsatile patterns of pituitary hormone gene expression change during development.
Journal of cell science 2011;124(Pt 20):3484-91.
2011: Tatiana Chebotareva; John J Mullins; Jane Taylor; Ian Wilmut
Rat eggs cannot wait: Spontaneous exit from meiotic metaphase-II arrest.
Molecular reproduction and development 2011;78(10-11):795-807.
2011: Catherine G Howard; John J Mullins; Kenneth D Mitchell
Direct renin inhibition with aliskiren normalizes blood pressure in Cyp1a1-Ren2 transgenic rats with inducible angiotensin ii-dependent malignant hypertension.
The American journal of the medical sciences 2011;341(5):383-7.
2011: Matthew A Bailey; Eilidh Craigie; Dawn E W Livingstone; Yuri Kotelevtsev; Emad A S Al-Dujaili; Christopher J Kenyon; John J Mullins
Hsd11b2 haploinsufficiency in mice causes salt sensitivity of blood pressure.
Hypertension 2011;57(3):515-20.
2011: Minolfa C Prieto; Dustyn E Williams; Liu Liu; Kimberly L Kavanagh; John J Mullins; Kenneth D Mitchell
Enhancement of renin and prorenin receptor in collecting duct of Cyp1a1-Ren2 rats may contribute to development and progression of malignant hypertension.
American journal of physiology. Renal physiology 2011;300(2):F581-8.
2010: Carlo J Milani; Hiroyuki Kobori; John J Mullins; Kenneth D Mitchell
Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension.
The American journal of the medical sciences 2010;340(5):389-94.
2010: Jonathan R Manning; Matthew A Bailey; Dinesh C Soares; Donald R Dunbar; John J Mullins
In silico structure-function analysis of pathological variation in the HSD11B2 gene sequence.
Physiological genomics 2010;42(3):319-30.
2010: Catherine G Howard; John J Mullins; Kenneth D Mitchell
Transient induction of ANG II-dependent malignant hypertension causes sustained elevation of blood pressure and augmentation of the pressor response to ANG II in CYP1A1-REN2 transgenic rats.
The American journal of the medical sciences 2010;339(6):543-8.
2010: Barbara S Peters; Beate Kuttler; Andreas Beineke; Gerd Lorenz; Andrea Thiele; Oliver Nicolai; Rainer Rettig; John J Mullins; Jörg Peters
The renin-angiotensin system as a primary cause of polyarteritis nodosa in rats.
Journal of cellular and molecular medicine 2010;14(6A):1318-27.
2010: Megan C Holmes; Roderick N Carter; June Noble; Shruti Chitnis; Amy Dutia; Janice M Paterson; John J Mullins; Jonathan R Seckl; Joyce L W Yau
11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(20):6916-20.
2010: Donald R Dunbar; Hiba Khaled; Louise C Evans; Emad A S Al-Dujaili; Linda J Mullins; John J Mullins; Christopher J Kenyon; Matthew A Bailey
Transcriptional and physiological responses to chronic ACTH treatment by the mouse kidney.
Physiological genomics 2010;40(3):158-66.
2010: Stephen Meek; Mia Buehr; Linda Sutherland; Alison Thomson; John J Mullins; Andrew J Smith; Tom Burdon
Efficient gene targeting by homologous recombination in rat embryonic stem cells.
PloS one 2010;5(12):e14225.
2009: R N Carter; Janice M Paterson; U Tworowska; D J Stenvers; John J Mullins; Jonathan R Seckl; Megan C Holmes
Hypothalamic-pituitary-adrenal axis abnormalities in response to deletion of 11beta-HSD1 is strain-dependent.
Journal of neuroendocrinology 2009;21(11):879-87.
2009: Matthew A Bailey; John J Mullins; Christopher J Kenyon
Mineralocorticoid and glucocorticoid receptors stimulate epithelial sodium channel activity in a mouse model of Cushing syndrome.
Hypertension 2009;54(4):890-6.
2009: Xiaojun Liu; Christopher O C Bellamy; Matthew A Bailey; Linda J Mullins; Donald R Dunbar; Christopher J Kenyon; Gillian Brooker; Surasak Kantachuvesiri; Klio Maratou; Ali Ashek; Allan F Clark; Stewart Fleming; John J Mullins
Angiotensin-converting enzyme is a modifier of hypertensive end organ damage.
The Journal of biological chemistry 2009;284(23):15564-72.
2009: Sabrina Semprini; Sonke Friedrichsen; Claire V Harper; Judith R McNeilly; Antony D Adamson; David G Spiller; N Kotelevtseva; Gillian Brooker; David G Brownstein; Alan S McNeilly; Michael R H White; Julian R E Davis; John J Mullins
Real-time visualization of human prolactin alternate promoter usage in vivo using a double-transgenic rat model.
Molecular endocrinology (Baltimore, Md.) 2009;23(4):529-38.
2009: Linda J Mullins; Audrey Peter; Nicola Wrobel; Judith R McNeilly; Alan S McNeilly; Emad A S Al-Dujaili; David G Brownstein; John J Mullins; Christopher J Kenyon
Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.
The Journal of biological chemistry 2009;284(6):3925-34.
2009: Jonathan R Manning; Ann Hedley; John J Mullins; Donald R Dunbar
Automated seeding of specialised wiki knowledgebases with BioKb.
BMC bioinformatics 2009;10():291.
2008: A D Adamson; S Friedrichsen; S Semprini; C V Harper; John J Mullins; Michael R H White; Julian R E Davis
Human prolactin gene promoter regulation by estrogen: convergence with tumor necrosis factor-alpha signaling.
Endocrinology 2008;149(2):687-94.
2008: Martin A Denvir; Carl S Tucker; John J Mullins
Systolic and diastolic ventricular function in zebrafish embryos: influence of norepenephrine, MS-222 and temperature.
BMC biotechnology 2008;8():21.
2008: Barbara Peters; Olaf Grisk; Bertram Becher; Heike Wanka; Beate Kuttler; Jan Lüdemann; Gerd Lorenz; Rainer Rettig; John J Mullins; Jörg Peters
Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis.
Journal of hypertension 2008;26(1):102-9.
2008: Matthew A Bailey; Janice M Paterson; Patrick W F Hadoke; Nicola Wrobel; Christopher O C Bellamy; David G Brownstein; Jonathan R Seckl; John J Mullins
A switch in the mechanism of hypertension in the syndrome of apparent mineralocorticoid excess.
Journal of the American Society of Nephrology : JASN 2008;19(1):47-58.
2007: Joyce L W Yau; Kara M McNair; June Noble; David G Brownstein; Carina Hibberd; Nik Morton; John J Mullins; Richard G M Morris; stuart cobb; Jonathan R Seckl
Enhanced hippocampal long-term potentiation and spatial learning in aged 11beta-hydroxysteroid dehydrogenase type 1 knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(39):10487-96.
2007: Simon B Brown; Carl S Tucker; Christopher Ford; Yfe Lee; Donald Dunbar; John J Mullins
Class III antiarrhythmic methanesulfonanilides inhibit leukocyte recruitment in zebrafish.
Journal of leukocyte biology 2007;82(1):79-84.
2007: Janice M Paterson; Megan C Holmes; Christopher J Kenyon; Roderick Carter; John J Mullins; Jonathan R Seckl
Liver-selective transgene rescue of hypothalamic-pituitary-adrenal axis dysfunction in 11beta-hydroxysteroid dehydrogenase type 1-deficient mice.
Endocrinology 2007;148(3):961-6.
2007: S Semprini; T J Troup; N Kotelevtseva; K King; J R E Davis; Linda J Mullins; Karen E Chapman; Donald Dunbar; John J Mullins
Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques.
Nucleic acids research 2007;35(5):1402-10.
2006: John J Mullins; Linda J Mullins; Donald Dunbar; William Brammar; Kenneth W Gross; Steven D Morley
Identification of a human ortholog of the mouse Dcpp gene locus, encoding a novel member of the CSP-1/Dcpp salivary protein family.
Physiological genomics 2006;28(1):129-40.
2006: Matthias Barton; John J Mullins; Matthew A Bailey; Matthias Kretzler
Role of endothelin receptors for renal protection and survival in hypertension: waiting for clinical trials.
Hypertension 2006;48(5):834-7.
2006: Valerie S Densmore; Nicholas M Morton; John J Mullins; Jonathan R Seckl
11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: A novel constraint to hyperphagia?
Endocrinology 2006;147(9):4486-95.
2006: James S Gilmour; Agnes E Coutinho; Jean-François Cailhier; Tak Yung Man; Michael Clay; Graham Thomas; Hayley J Harris; John J Mullins; Jonathan R Seckl; John Savill; Karen E Chapman
Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7605-11.
2006: Megan C Holmes; Christian T Abrahamsen; Karen L French; Janice M Paterson; John J Mullins; Jonathan R Seckl
The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(14):3840-4.
2006: Linda J Mullins; Matthew A Bailey; John J Mullins
Hypertension, kidney, and transgenics: a fresh perspective.
Physiological reviews 2006;86(2):709-46.
2006: Egidius H J Heerkens; Linda Shaw; Alisdair Ryding; Gillian Brooker; John J Mullins; Clare Austin; Vasken Ohanian; Anthony M Heagerty
alphaV integrins are necessary for eutrophic inward remodeling of small arteries in hypertension.
Hypertension 2006;47(2):281-7.
2006: Megan C Holmes; M Sangra; Karen L French; Ian R Whittle; J Paterson; John J Mullins; Jonathan R Seckl
11beta-Hydroxysteroid dehydrogenase type 2 protects the neonatal cerebellum from deleterious effects of glucocorticoids.
Neuroscience 2006;137(3):865-73.
2006: Sönke Friedrichsen; Claire V Harper; Sabrina Semprini; Michael Wilding; Antony D Adamson; Dave G Spiller; Glyn Nelson; John J Mullins; Michael R H White; Julian R E Davis
Tumor necrosis factor-alpha activates the human prolactin gene promoter via nuclear factor-kappaB signaling.
Endocrinology 2006;147(2):773-81.
2005: P Ye; Christopher J Kenyon; Scott M MacKenzie; A S Jong; C Miller; Gillian A Gray; A Wallace; A S Ryding; John J Mullins; M W McBride; D Graham; Robert Fraser; John M C Connell; Eleanor Davies
The aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart.
Endocrinology 2005;146(12):5287-93.
2005: Tom Van Agtmael; Ursula Schlötzer-Schrehardt; Lisa McKie; David G Brownstein; Angela W Lee; Sally H Cross; Yoshikazu Sado; John J Mullins; Ernst Pöschl; Ian J Jackson
Dominant mutations of Col4a1 result in basement membrane defects which lead to anterior segment dysgenesis and glomerulopathy.
Human molecular genetics 2005;14(21):3161-8.
2005: Janice M Paterson; Jonathan R Seckl; John J Mullins
Genetic manipulation of 11beta-hydroxysteroid dehydrogenases in mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;289(3):R642-52.
2004: Gurman S Pall; Julie Wallis; Richard Axton; David G Brownstein; Philippe Gautier; Katrin Buerger; Christine Mulford; John J Mullins; Lesley Forrester
A novel transmembrane MSP-containing protein that plays a role in right ventricle development.
Genomics 2004;84(6):1051-9.
2004: Janice M Paterson; Nicholas M Morton; Catherine Fievet; Christopher J Kenyon; Megan C Holmes; Bart Staels; Jonathan R Seckl; John J Mullins
Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7088-93.
2004: Nicholas M Morton; Janice M Paterson; Hiroaki Masuzaki; Megan C Holmes; Bart Staels; Catherine Fievet; Brian R Walker; Jeffrey S Flier; John J Mullins; Jonathan R Seckl
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.
Diabetes 2004;53(4):931-8.
2004: Linda J Mullins; John J Mullins
Large transgenes reveal their secrets. Focus on "differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice".
Physiological genomics 2004;17(1):1-3.
2004: Tara A Collidge; G Alistair Lammie; Stewart Fleming; John J Mullins
The role of the renin-angiotensin system in malignant vascular injury affecting the systemic and cerebral circulations.
Progress in biophysics and molecular biology 2004;84(2-3):301-19.
2004: Linda J Mullins; John J Mullins
Insights from the rat genome sequence.
Genome biology 2004;5(5):221.
2004: Linda J Mullins; Ian Wilmut; John J Mullins
Nuclear transfer in rodents.
The Journal of physiology 2004;554(Pt 1):4-12.
2003: Megan C Holmes; Joyce L W Yau; Yuri Kotelevtsev; John J Mullins; Jonathan R Seckl
11 Beta-hydroxysteroid dehydrogenases in the brain: two enzymes two roles.
Annals of the New York Academy of Sciences 2003;1007():357-66.
2003: Clare Christy; Patrick W F Hadoke; Janice M Paterson; John J Mullins; Jonathan R Seckl; Brian R Walker
11beta-hydroxysteroid dehydrogenase type 2 in mouse aorta: localization and influence on response to glucocorticoids.
Hypertension 2003;42(4):580-7.
2003: Hiroaki Masuzaki; Hiroshi Yamamoto; Christopher J Kenyon; Joel K Elmquist; Nicholas M Morton; Janice M Paterson; Hiroshi Shinyama; Matthew G F Sharp; Stewart Fleming; John J Mullins; Jonathan R Seckl; Jeffrey S Flier
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.
The Journal of clinical investigation 2003;112(1):83-90.
2002: S Hundertmark; A Dill; Andreas Ebert; B Zimmermann; Yuri Kotelevtsev; John J Mullins; Jonathan R Seckl
Foetal lung maturation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(10):545-9.
2002: Jörg Peters; Raphaela Farrenkopf; Susanne Clausmeyer; Jutta Zimmer; Surasak Kantachuvesiri; Matthew G F Sharp; John J Mullins
Functional significance of prorenin internalization in the rat heart.
Circulation research 2002;90(10):1135-41.
2002: N J Mayer; A Forsyth; Surasak Kantachuvesiri; John J Mullins; Stewart Fleming
Association of the D allele of the angiotensin I converting enzyme polymorphism with malignant vascular injury.
Molecular pathology : MP 2002;55(1):29-33.
2002: Linda J Mullins; Gillian Brooker; John J Mullins
Transgenesis in the rat.
Methods in molecular biology (Clifton, N.J.) 2002;180():255-70.
2001: Hiroaki Masuzaki; J Paterson; Hiroshi Shinyama; Nicholas M Morton; John J Mullins; Jonathan R Seckl; Jeffrey S Flier
A transgenic model of visceral obesity and the metabolic syndrome.
Science (New York, N.Y.) 2001;294(5549):2166-70.
2001: Patrick W F Hadoke; C Christy; Yuri Kotelevtsev; BC Williams; Christopher J Kenyon; Jonathan R Seckl; John J Mullins; Brian R Walker
Endothelial cell dysfunction in mice after transgenic knockout of type 2, but not type 1, 11beta-hydroxysteroid dehydrogenase.
Circulation 2001;104(23):2832-7.
2001: Nicholas M Morton; Megan C Holmes; Catherine Fiévet; Bart Staels; Anne Tailleux; John J Mullins; Jonathan R Seckl
Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice.
The Journal of biological chemistry 2001;276(44):41293-300.
2001: A D Ryding; Matthew G F Sharp; John J Mullins
Conditional transgenic technologies.
The Journal of endocrinology 2001;171(1):1-14.
2001: Surasak Kantachuvesiri; Stewart Fleming; Jörg Peters; B Peters; Gillian Brooker; A G Lammie; I McGrath; Yuri Kotelevtsev; John J Mullins
Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease.
The Journal of biological chemistry 2001;276(39):36727-33.
2001: Joyce L W Yau; June Noble; Christopher J Kenyon; Carina Hibberd; Yuri Kotelevtsev; John J Mullins; Jonathan R Seckl
Lack of tissue glucocorticoid reactivation in 11beta -hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4716-21.
2001: Megan C Holmes; Yuri Kotelevtsev; John J Mullins; Jonathan R Seckl
Phenotypic analysis of mice bearing targeted deletions of 11beta-hydroxysteroid dehydrogenases 1 and 2 genes.
Molecular and cellular endocrinology 2001;171(1-2):15-20.
2001: H J Harris; Yuri Kotelevtsev; John J Mullins; Jonathan R Seckl; Megan C Holmes
Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice.
Endocrinology 2001;142(1):114-20.
2000: Linda J Mullins; C M Payne; N Kotelevtseva; Gillian Brooker; Stewart Fleming; S Harris; John J Mullins
Granulation rescue and developmental marking of juxtaglomerular cells using "piggy-BAC" recombination of the mouse ren locus.
The Journal of biological chemistry 2000;275(51):40378-84.
1999: C M Payne; Linda J Mullins; John J Mullins
Manipulating large genomic clones via in vivo recombination in bacteria.
Journal of human hypertension 1999;13(12):845-8.
1999: Surasak Kantachuvesiri; C S Haley; Stewart Fleming; Kathreena M Kurian; C E Whitworth; P Wenham; Yuri Kotelevtsev; John J Mullins
Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats.
Kidney international 1999;56(2):414-20.
1999: Yuri Kotelevtsev; Roger W Brown; Stewart Fleming; C Kenyon; C R Edwards; Jonathan R Seckl; John J Mullins
Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2.
The Journal of clinical investigation 1999;103(5):683-9.
1998: Hugh E Montgomery; L A Kiernan; C E Whitworth; S Fleming; T Unger; Peter Gohlke; John J Mullins; Jean R McEwan
Inhibition of tissue angiotensin converting enzyme activity prevents malignant hypertension in TGR(mREN2)27.
Journal of hypertension 1998;16(5):635-43.
1997: Yuri Kotelevtsev; Megan C Holmes; A Burchell; Pamela Houston; Dieter Schmoll; PM Jamieson; R Best; R Brown; C R Edwards; Jonathan R Seckl; John J Mullins
11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14924-9.
1997: A F Clark; Matthew G F Sharp; Steven D Morley; Stewart Fleming; Jörg Peters; John J Mullins
Renin-1 is essential for normal renal juxtaglomerular cell granulation and macula densa morphology.
The Journal of biological chemistry 1997;272(29):18185-90.
1997: Linda J Mullins; N Kotelevtseva; A Christopher Boyd; John J Mullins
Efficient Cre-lox linearisation of BACs: applications to physical mapping and generation of transgenic animals.
Nucleic acids research 1997;25(12):2539-40.
1997: Karen E Chapman; Yuri Kotelevtsev; PM Jamieson; Linda Williams; John J Mullins; Jonathan R Seckl
Tissue-specific modulation of glucocorticoid action by the 11 beta-hydroxysteroid dehydrogenases.
Biochemical Society transactions 1997;25(2):583-7.
1997: Matthew G F Sharp; Surasak Kantachuvesiri; John J Mullins
Genotype and cardiovascular phenotype: lessons from genetically manipulated animals and diseased humans.
Current opinion in nephrology and hypertension 1997;6(1):51-7.
1996: Matthew G F Sharp; D Fettes; G Brooker; A F Clark; J Peters; S Fleming; John J Mullins
Targeted inactivation of the Ren-2 gene in mice.
Hypertension 1996;28(6):1126-31.
1996: Steven D Morley; I Viard; K L Parker; John J Mullins
Adrenocortical-specific transgene expression directed by steroid hydroxylase gene promoters.
Endocrine research 1996;22(4):631-9.
1996: G C Dell; Steven D Morley; John J Mullins; BC Williams; Simon W Walker
Multiple signal transduction systems regulate angiotensin II type 1 (AT1) receptor mRNA expression in bovine adrenocortical cells.
Endocrine research 1996;22(4):363-8.
1996: Linda J Mullins; Steven D Morley; John J Mullins
Transgenics and essential hypertension.
Journal of human hypertension 1996;10(10):627-31.
1996: A F Clark; Matthew G F Sharp; John J Mullins
Gene targeting and its application to basic hypertension research.
Clinical science (London, England : 1979) 1996;90(6):435-46.
1996: Steven D Morley; I Viard; B C Chung; Y Ikeda; K L Parker; John J Mullins
Variegated expression of a mouse steroid 21-hydroxylase/beta- galactosidase transgene suggests centripetal migration of adrenocortical cells.
Molecular endocrinology (Baltimore, Md.) 1996;10(5):585-98.
1996: Linda J Mullins; John J Mullins
Transgenesis in the rat and larger mammals.
The Journal of clinical investigation 1996;97(7):1557-60.
1996: R W Brown; Karen E Chapman; Yuri Kotelevtsev; J L Yau; R S Lindsay; L Brett; C Leckie; P Murad; Val Lyons; John J Mullins; C R Edwards; J R Seckl
Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2.
The Biochemical journal 1996;313 ( Pt 3)():1007-17.
1996: R W Brown; R Diaz; A C Robson; Yuri Kotelevtsev; John J Mullins; M H Kaufman; J R Seckl
The ontogeny of 11 beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development.
Endocrinology 1996;137(2):794-7.
1995: M Véniant; C E Whitworth; J Ménard; Matthew G F Sharp; M F Gonzales; P Bruneval; John J Mullins
Developmental studies demonstrate age-dependent elevation of renin activity in TGR(mRen2)27 rats.
American journal of hypertension 1995;8(12 Pt 1):1167-76.
1995: C E Whitworth; M M Veniant; J D Firth; A D Cumming; John J Mullins
Endothelin in the kidney in malignant phase hypertension.
Hypertension 1995;26(6 Pt 1):925-31.
1995: V Rajan; Karen E Chapman; Val Lyons; PM Jamieson; John J Mullins; C R Edwards; J R Seckl
Cloning, sequencing and tissue-distribution of mouse 11 beta-hydroxysteroid dehydrogenase-1 cDNA.
The Journal of steroid biochemistry and molecular biology 1995;52(2):141-7.
1995: C E Whitworth; Stewart Fleming; Yuri Kotelevtsev; L Manson; G A Brooker; A D Cumming; John J Mullins
A genetic model of malignant phase hypertension in rats.
Kidney international 1995;47(2):529-35.
1995: Steven D Morley; I Viard; K L Parker; John J Mullins
Adrenal-specific transgene expression and derivation of conditionally immortal rat adrenocortical cell lines.
Endocrine research 1995;21(1-2):353-7.
1994: C E Whitworth; Stewart Fleming; A D Cumming; J J Morton; N J Burns; BC Williams; John J Mullins
Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats.
Kidney international 1994;46(6):1528-32.
1994: John J Mullins; Linda J Mullins
Transgenes, hypotheses, and hypertension.
Hypertension 1994;23(4):428-30.
1993: John J Mullins; Linda J Mullins
Transgenesis in nonmurine species.
Hypertension 1993;22(4):630-3.
1993: Matthew G F Sharp; John J Mullins
Loss of gene function methodology.
Journal of hypertension 1993;11(4):339-43.
1992: G L Barrett; John J Mullins
Studies on blood pressure regulation in hypertensive ren-2 transgenic rats.
Kidney international. Supplement 1992;37():S125-8.
1992: G L Barrett; John J Mullins
Strategies towards a transgenic model of essential hypertension.
Biochemical pharmacology 1992;43(5):925-30.