FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Gerd Multhaup

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Physiology

Mutation

Co-author Network

Publications

TOP 3
Susanne Holzhauser; Gerd Multhaup; Anja Freiwald; Chung-Ting Han; Christoph Weise; Sascha Sauer
Discovery and Characterization of Protein-Modifying Natural Products by MALDI Mass Spectrometry Reveal Potent SIRT1 and p300 Inhibitors.
Nahuai Badiola; Mireia Coma; Alberto Lleó; Gerd Multhaup; Lisa-Marie Münter; Albert Pujol; Montserrat Soler-López; Victor Alcalde; Patrick Aloy
The proton-pump inhibitor lansoprazole enhances amyloid beta production.
Daniela Kaden; Gerd Multhaup
Meeting report: 7th fabisch symposium for cancer research and molecular cell biology - regulated intramembrane proteolysis in cancer development and neurodegenerative diseases.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Gerd Multhaup (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Susanne Holzhauser; Gerd Multhaup; Anja Freiwald; Chung-Ting Han; Christoph Weise; Sascha Sauer
Discovery and Characterization of Protein-Modifying Natural Products by MALDI Mass Spectrometry Reveal Potent SIRT1 and p300 Inhibitors.
Angewandte Chemie (International ed. in English) 2013;52(19):5171-4.
2013: Nahuai Badiola; Mireia Coma; Alberto Lleó; Gerd Multhaup; Lisa-Marie Münter; Albert Pujol; Montserrat Soler-López; Victor Alcalde; Patrick Aloy
The proton-pump inhibitor lansoprazole enhances amyloid beta production.
PloS one 2013;8(3):e58837.
2013: Daniela Kaden; Gerd Multhaup
Meeting report: 7th fabisch symposium for cancer research and molecular cell biology - regulated intramembrane proteolysis in cancer development and neurodegenerative diseases.
Neuro-degenerative diseases 2013;11():215-8.
2012: Christian Hoppmann; Dorothea Lorenz; Gerd Multhaup; Christian Barucker; Michael Beyermann
Light-controlled toxicity of engineered amyloid β-peptides.
Chembiochem : a European journal of chemical biology 2012;13(18):2657-60.
2012: Ulrike K Resenberger; Mark R Wilson; Konstanze F Winklhofer; Michael Baier; Veronika Müller; Gerd Multhaup; Lisa M Munter; Jörg Tatzelt
The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β.
The Journal of biological chemistry 2012;287(52):43765-76.
2012: Jessica Bien; Tamara Jefferson; Thorsten Jumpertz; Gerd Multhaup; Lisa Munter; Sascha Weggen; Mirsada Causevic; Christoph Becker-Pauly; Claus U Pietrzik
The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species.
The Journal of biological chemistry 2012;287(40):33304-13.
2012: Cary Esselens; Rodrigo Gallardo; Daniela Kaden; Johannes P M Langedijk; Gerd Multhaup; Frederic Rousseau; Ragna Sannerud; Joost Schymkowitz; Lutgarde Serneels; Veerle Baert; Bart De Strooper; Willem ANNAERT
Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(9):3765-78.
2012: Daniela Kaden; Rudi Lurz; Veit Althoff; Sönke Arlt; Ulrich Finckh; Anja Harmeier; Peter W Hildebrand; Lisa M Munter; Benjamin R Rost; Michael Schaefer; Dietmar Schmitz; Sabine Skodda; Christoph Weise; Raina Yamamoto; Gerd Multhaup
Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers.
EMBO molecular medicine 2012;4(7):647-59.
2012: Simone Isbert; Stefan Kins; Gerd Multhaup; Andrea Schweitzer; Katja Wagner; Sascha Weggen; Simone Eggert; Claus U Pietrzik
APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms.
Cellular and molecular life sciences : CMLS 2012;69(8):1353-75.
2012: Daniela Kaden; Lisa Marie Munter; Bernd Reif; Gerd Multhaup
The amyloid precursor protein and its homologues: structural and functional aspects of native and pathogenic oligomerization.
European journal of cell biology 2012;91(4):234-9.
2012: Sven O Dahms; Karl-Heinz Gührs; Daniela Kaden; Ina Könnig; Magnus C Mayer; Gerd Multhaup; Dirk Roeser; Manuel E Than
Metal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domain.
Journal of molecular biology 2012;416(3):438-52.
2011: Patricia Klose; Gerd Multhaup; Christoph Weise; Angelika Bondzio; Ralf Einspanier; Achim D Gruber; Robert Klopfleisch
Is there a malignant progression associated with a linear change in protein expression levels from normal canine mammary gland to metastatic mammary tumors?
Journal of proteome research 2011;10(10):4405-15.
2011: Haiqing Hua; Gerd Multhaup; Lisa Münter; Oleg Georgiev; Anja Harmeier; Walter Schaffner
Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability.
Biological chemistry 2011;392(10):919-26.
2011: Fang Cheng; Giuseppe D Ciccotosto; Lars-Åke Fransson; Gerd Multhaup; Gabriel Svensson; Roberto Cappai; Katrin Mani
Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation.
The Journal of biological chemistry 2011;286(31):27559-72.
2011: Ulrike K Resenberger; Anja Harmeier; Andreas C Woerner; Jessica L Goodman; Veronika Müller; Rajaraman Krishnan; R Martin Vabulas; Hans A Kretzschmar; Susan Lindquist; F Ulrich Hartl; Gerd Multhaup; Konstanze F Winklhofer; Jörg Tatzelt
The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication.
The EMBO journal 2011;30(10):2057-70.
2011: Michael T Heneka; Markus P Kummer; Sascha Weggen; B Bulic; Gerd Multhaup; L Münter; M Hüll; T Pflanzner; Claus U Pietrzik
Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease.
Current Alzheimer research 2011;8(2):115-31.
2011: Anne Botev; Lisa-Marie Munter; Ringo Wenzel; Luise Richter; Veit Althoff; Jochen Ismer; Ulla Gerling; Christoph Weise; Beate Koksch; Peter W Hildebrand; Robert Bittl; Gerd Multhaup
The amyloid precursor protein C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulators.
Biochemistry 2011;50(5):828-35.
2011: Daniela Kaden; Thomas A Bayer; Ashley I Bush; Ruth Danzeisen; Gerd Multhaup
Disturbed copper bioavailability in Alzheimer's disease.
International journal of Alzheimer's disease 2011;2011():345614.
2010: Oliver Wirths; Christian Erck; Henrik Martens; Anja Harmeier; Constanze Geumann; Sadim Jawhar; Sathish Kumar; Gerd Multhaup; Jochen Walter; Martin Ingelsson; Malin Degerman-Gunnarsson; Hannu Kalimo; Inge Huitinga; Lars Lannfelt; Thomas A Bayer
Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.
The Journal of biological chemistry 2010;285(53):41517-24.
2010: Robert Klopfleisch; Patricia Klose; Christoph Weise; Angelika Bondzio; Gerd Multhaup; Ralf Einspanier; Achim D Gruber
Proteome of metastatic canine mammary carcinomas: similarities to and differences from human breast cancer.
Journal of proteome research 2010;9(12):6380-91.
2010: Luise Richter; Lisa-Marie Munter; Julia Ness; Peter W Hildebrand; Muralidhar Dasari; Stephanie Unterreitmeier; Bruno Bulic; Michael Beyermann; Ronald Gust; Bernd Reif; Sascha Weggen; Dieter Langosch; Gerd Multhaup
Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(33):14597-602.
2010: Lisa-Marie Munter; Anne Botev; Luise Richter; Peter W Hildebrand; Veit Althoff; Christoph Weise; Daniela Kaden; Gerd Multhaup
Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.
The Journal of biological chemistry 2010;285(28):21636-43.
2010: Kristin T Jacobsen; Linda Adlerz; Gerd Multhaup; Kerstin Iverfeldt
Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases.
The Journal of biological chemistry 2010;285(14):10223-31.
2010: Oliver Wirths; Tobias Bethge; Andrea Marcello; Anja Harmeier; Sadim Jawhar; Paul J Lucassen; Gerd Multhaup; David L Brody; Thomas Esparza; Martin Ingelsson; Hannu Kalimo; Lars Lannfelt; Thomas A Bayer
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases.
Journal of neural transmission (Vienna, Austria : 1996) 2010;117(1):85-96.
2009: Anja Harmeier; Christian Wozny; Benjamin R Rost; Lisa-Marie Munter; Haiqing Hua; Oleg Georgiev; Michael Beyermann; Peter W Hildebrand; Christoph Weise; Walter Schaffner; Dietmar Schmitz; Gerd Multhaup
Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(23):7582-90.
2009: Carina Treiber; Mohiuddin Abdul Quadir; Philipp Voigt; Michal Radowski; Shangjie Xu; Lisa-Marie Munter; Thomas A Bayer; Michael Schaefer; Rainer Haag; Gerd Multhaup
Cellular copper import by nanocarrier systems, intracellular availability, and effects on amyloid beta peptide secretion.
Biochemistry 2009;48(20):4273-84.
2009: Daniela Kaden; Philipp Voigt; Lisa-Marie Munter; Karolina D Bobowski; Michael Schaefer; Gerd Multhaup
Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2.
Journal of cell science 2009;122(Pt 3):368-77.
2008: Holger Kessler; Frank-Gerald Pajonk; Daniela Bach; Thomas Schneider-Axmann; Peter Falkai; Wolfgang Herrmann; Gerd Multhaup; Jens Wiltfang; Stephanie Schäfer; Oliver Wirths; Thomas A Bayer
Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial.
Journal of neural transmission (Vienna, Austria : 1996) 2008;115(12):1651-9.
2008: Holger Kessler; Thomas A Bayer; Daniela Bach; Thomas Schneider-Axmann; Tillmann Supprian; Wolfgang Herrmann; Manfred Haber; Gerd Multhaup; Peter Falkai; Frank-Gerald Pajonk
Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial.
Journal of neural transmission (Vienna, Austria : 1996) 2008;115(8):1181-7.
2008: Daniela Kaden; Lisa-Marie Munter; Mangesh Joshi; Carina Treiber; Christoph Weise; Tobias Bethge; Philipp Voigt; Michael Schaefer; Michael Beyermann; Bernd Reif; Gerd Multhaup
Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP.
The Journal of biological chemistry 2008;283(11):7271-9.
2007: Carina Treiber; Andrew R Thompsett; Rüdiger Pipkorn; David Brown; Gerd Multhaup
Real-time kinetics of discontinuous and highly conformational metal-ion binding sites of prion protein.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2007;12(5):711-20.
2007: Linda Adlerz; Sofia Holback; Gerd Multhaup; Kerstin Iverfeldt
IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways.
The Journal of biological chemistry 2007;282(14):10203-9.
2007: Stephanie Schäfer; Frank-Gerald Pajonk; Gerd Multhaup; Thomas A Bayer
Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels.
Journal of molecular medicine (Berlin, Germany) 2007;85(4):405-13.
2007: Lisa-Marie Munter; Philipp Voigt; Anja Harmeier; Daniela Kaden; Kay-Eberhard Gottschalk; Christoph Weise; Rüdiger Pipkorn; Michael Schaefer; Dieter Langosch; Gerd Multhaup
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.
The EMBO journal 2007;26(6):1702-12.
2007: Carina Treiber; Rüdiger Pipkorn; Christoph Weise; Gudrun Holland; Gerd Multhaup
Copper is required for prion protein-associated superoxide dismutase-I activity in Pichia pastoris.
The FEBS journal 2007;274(5):1304-11.
2007: Stephanie Schäfer; Oliver Wirths; Gerd Multhaup; Thomas A Bayer
Gender dependent APP processing in a transgenic mouse model of Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2007;114(3):387-94.
2006: H Kessler; Frank-Gerald Pajonk; P Meisser; Thomas Schneider-Axmann; K-H Hoffmann; Tillmann Supprian; W Herrmann; R Obeid; Gerd Multhaup; Peter Falkai; Thomas A Bayer
Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(11):1763-9.
2006: Angel Llamas; Tanja Otte; Gerd Multhaup; Ralf R Mendel; Günter Schwarz
The Mechanism of nucleotide-assisted molybdenum insertion into molybdopterin. A novel route toward metal cofactor assembly.
The Journal of biological chemistry 2006;281(27):18343-50.
2006: Thomas A Bayer; S Schäfer; H Breyhan; Oliver Wirths; Carina Treiber; Gerd Multhaup
A vicious circle: role of oxidative stress, intraneuronal Abeta and Cu in Alzheimer's disease.
Clinical neuropathology 2006;25(4):163-71.
2006: Carina Treiber; Andreas Simons; Gerd Multhaup
Effect of copper and manganese on the de novo generation of protease-resistant prion protein in yeast cells.
Biochemistry 2006;45(21):6674-80.
2006: Oliver Wirths; Joachim Weis; Jacek Szczygielski; Gerd Multhaup; Thomas A Bayer
Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease.
Acta neuropathologica 2006;111(4):312-9.
2006: Dieter Egli; Hasmik Yepiskoposyan; Anand Selvaraj; Kuppusamy Balamurugan; Rama Rajaram; Andreas Simons; Gerd Multhaup; Simone Mettler; Alla Vardanyan; Oleg Georgiev; Walter Schaffner
A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification.
Molecular and cellular biology 2006;26(6):2286-96.
2006: Gerd Multhaup
Amyloid precursor protein and BACE function as oligomers.
Neuro-degenerative diseases 2006;3(4-5):270-4.
2006: Hasmik Yepiskoposyan; Dieter Egli; Tim Fergestad; Anand Selvaraj; Carina Treiber; Gerd Multhaup; Oleg Georgiev; Walter Schaffner
Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc.
Nucleic acids research 2006;34(17):4866-77.
2005: Fang F Yuan; Sandra Biffin; Marcus Brazier; Monica Suarez; Roberto Cappai; Andrew Hill; Steven J Collins; John Sullivan; Deborah Middleton; Gerd Multhaup; Andrew F Geczy; Colin L Masters
Detection of prion epitopes on PrP and PrP of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP.
Immunology and cell biology 2005;83(6):632-7.
2005: Thomas A Bayer; Gerd Multhaup
Involvement of amyloid beta precursor protein (AbetaPP) modulated copper homeostasis in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2005;8(2):201-6; discussion 209-15.
2005: Frank-Gerald Pajonk; Holger Kessler; Tillmann Supprian; Pegah Hamzei; Daniela Bach; Janina Schweickhardt; Wolfgang Herrmann; Rima Obeid; Andreas Simons; Peter Falkai; Gerd Multhaup; Thomas A Bayer
Cognitive decline correlates with low plasma concentrations of copper in patients with mild to moderate Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2005;8(1):23-7.
2005: H Kessler; Frank-Gerald Pajonk; Tillmann Supprian; Peter Falkai; Gerd Multhaup; T A Bayer
[The role of copper in the pathophysiology of Alzheimer's disease].
Der Nervenarzt 2005;76(5):581-5.
2005: Roberto Cappai; Fang Cheng; Giuseppe D Ciccotosto; B Elise Needham; Colin L Masters; Gerd Multhaup; Lars-Ake Fransson; Katrin Mani
The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo.
The Journal of biological chemistry 2005;280(14):13913-20.
2004: Gil G Westmeyer; Michael Willem; Stefan F Lichtenthaler; Glenn Lurman; Gerd Multhaup; Irmgard Assfalg-Machleidt; Karina Reiss; Paul Saftig; Christian Haass
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.
The Journal of biological chemistry 2004;279(51):53205-12.
2004: Carina Treiber; Andreas Simons; Markus Strauss; Mathias Hafner; Roberto Cappai; Thomas A Bayer; Gerd Multhaup
Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease.
The Journal of biological chemistry 2004;279(50):51958-64.
2004: Oliver Wirths; Gerd Multhaup; Thomas A Bayer
A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade.
Journal of neurochemistry 2004;91(3):513-20.
2004: Ariane Schmechel; Markus Strauss; Andrea Schlicksupp; Rüdiger Pipkorn; Christian Haass; Thomas A Bayer; Gerd Multhaup
Human BACE forms dimers and colocalizes with APP.
The Journal of biological chemistry 2004;279(38):39710-7.
2004: Reto Portmann; David Magnani; Jivko V Stoyanov; Ariane Schmechel; Gerd Multhaup; Marc Solioz
Interaction kinetics of the copper-responsive CopY repressor with the cop promoter of Enterococcus hirae.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(4):396-402.
2004: Shayne A Bellingham; Debomoy K Lahiri; Bryan Maloney; Sharon La Fontaine; Gerd Multhaup; James Camakaris
Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene.
The Journal of biological chemistry 2004;279(19):20378-86.
2004: Christoph Schmitz; Bart P F Rutten; Andrea Pielen; Stephanie Schäfer; Oliver Wirths; Günter Tremp; Christian Czech; Véronique Blanchard; Gerd Multhaup; Payam Rezaie; Hubert Korr; Harry W M Steinbusch; Laurent Pradier; Thomas A Bayer
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease.
The American journal of pathology 2004;164(4):1495-502.
2004: Klaus Fassbender; Silke Walter; Sandra Kühl; Regine Landmann; K Ishii; Thomas Bertsch; Anna K Stalder; Frank Muehlhauser; Yang Liu; Artur J Ulmer; Serge Rivest; Arnd Lentschat; E Gulbins; Mathias Jucker; Matthias Staufenbiel; Katrin Brechtel; J Walter; Gerd Multhaup; Botond Penke; Y Adachi; Tobias Hartmann; Konrad Beyreuther
The LPS receptor (CD14) links innate immunity with Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):203-5.
2003: Thomas A Bayer; Stephanie Schäfer; Andreas Simons; André Kemmling; Thomas Kamer; Ralf Tepest; Anne Eckert; Katrin Schüssel; Oliver Eikenberg; Christine Sturchler-Pierrat; Dorothee Abramowski; Matthias Staufenbiel; Gerd Multhaup
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14187-92.
2003: Ariane Schmechel; Hanswalter Zentgraf; Stefan Scheuermann; Guenter Fritz; Rüdiger Pipkorn; Jennifer Reed; Konrad Beyreuther; Thomas A Bayer; Gerd Multhaup
Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies.
The Journal of biological chemistry 2003;278(37):35317-24.
2003: Daniel Strausak; Michelle K Howie; Stephen D Firth; Andrea Schlicksupp; Rüdiger Pipkorn; Gerd Multhaup; Julian F B Mercer
Kinetic analysis of the interaction of the copper chaperone Atox1 with the metal binding sites of the Menkes protein.
The Journal of biological chemistry 2003;278(23):20821-7.
2003: Kevin J Barnham; William J McKinstry; Gerd Multhaup; Denise Galatis; Craig J Morton; Cyril C Curtain; Nicholas A Williamson; Anthony R White; Mark G Hinds; Raymond S Norton; Konrad Beyreuther; Colin L Masters; Michael W Parker; Roberto Cappai
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.
The Journal of biological chemistry 2003;278(19):17401-7.
2003: Anthony R White; Fran Maher; Marcus Brazier; Michael F Jobling; James Thyer; Leanne R Stewart; Andrew Thompson; Riki Gibson; Colin L Masters; Gerd Multhaup; Konrad Beyreuther; Colin J Barrow; Steven J Collins; Roberto Cappai
Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation.
Brain research 2003;966(2):231-44.
2003: Bart P F Rutten; Oliver Wirths; Wilma D J Van De Berg; Stefan F Lichtenthaler; Jochen Vehoff; Harry W M Steinbusch; Hubert Korr; Konrad Beyreuther; Gerd Multhaup; Thomas A Bayer; Christoph Schmitz
No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment.
Neurobiology of disease 2003;12(2):110-20.
2003: Regina Fluhrer; Gerd Multhaup; Andrea Schlicksupp; Masayasu Okochi; Masatoshi Takeda; Sven Lammich; Michael Willem; Gil G Westmeyer; Wolfram Bode; Jochen Walter; Christian Haass
Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.
The Journal of biological chemistry 2003;278(8):5531-8.
2002: Andreas Simons; Thomas Ruppert; Carsten Schmidt; Andrea Schlicksupp; Rüdiger Pipkorn; Jennifer Reed; Colin L Masters; Anthony R White; Roberto Cappai; Konrad Beyreuther; Thomas A Bayer; Gerd Multhaup
Evidence for a copper-binding superfamily of the amyloid precursor protein.
Biochemistry 2002;41(30):9310-20.
2002: Oliver Wirths; Gerd Multhaup; Christian Czech; Nicole Feldmann; Véronique Blanchard; Günter Tremp; Konrad Beyreuther; Laurent Pradier; Thomas A Bayer
Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice.
Brain pathology (Zurich, Switzerland) 2002;12(3):275-86.
2002: Dieter Lütjohann; Andreas Brzezinka; Esther Barth; Dorothee Abramowski; Matthias Staufenbiel; Klaus Von Bergmann; Konrad Beyreuther; Gerd Multhaup; Thomas A Bayer
Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain.
Journal of lipid research 2002;43(7):1078-85.
2002: Gerd Multhaup; Stefan Scheuermann; Andrea Schlicksupp; Andreas Simons; Markus Strauss; André Kemmling; Christian Oehler; Roberto Cappai; Rüdiger Pipkorn; Thomas A Bayer
Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease.
Free radical biology & medicine 2002;33(1):45-51.
2002: Klaus Schümann; H G Classen; H H Dieter; J König; Gerd Multhaup; M Rükgauer; K H Summer; J Bernhardt; H K Biesalski
Hohenheim consensus workshop: copper.
European journal of clinical nutrition 2002;56(6):469-83.
2002: Anthony R White; Gerd Multhaup; Denise Galatis; William J McKinstry; Michael W Parker; Rüdiger Pipkorn; Konrad Beyreuther; Colin L Masters; Roberto Cappai
Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(2):365-76.
2001: Oliver Wirths; Gerd Multhaup; Christian Czech; Véronique Blanchard; Günter Tremp; Laurent Pradier; Konrad Beyreuther; Thomas A Bayer
Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice.
Neuroscience letters 2001;316(3):145-8.
2001: Gerd Multhaup; Daniel Strausak; Karl-Dimiter Bissig; Marc Solioz
Interaction of the CopZ copper chaperone with the CopA copper ATPase of Enterococcus hirae assessed by surface plasmon resonance.
Biochemical and biophysical research communications 2001;288(1):172-7.
2001: Stefan Scheuermann; B Hambsch; L Hesse; J Stumm; C Schmidt; Dirk Beher; Thomas A Bayer; Konrad Beyreuther; Gerd Multhaup
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.
The Journal of biological chemistry 2001;276(36):33923-9.
2001: M Sastre; Harald Steiner; K Fuchs; Anja Capell; Gerd Multhaup; Margaret M Condron; David B Teplow; Christian Haass
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch.
EMBO reports 2001;2(9):835-41.
2001: Oliver Wirths; Gerd Multhaup; Christian Czech; Véronique Blanchard; Saliha Moussaoui; Günter Tremp; Laurent Pradier; Konrad Beyreuther; Thomas A Bayer
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.
Neuroscience letters 2001;306(1-2):116-20.
2001: Daniel Strausak; Julian F B Mercer; H H Dieter; W Stremmel; Gerd Multhaup
Copper in disorders with neurological symptoms: Alzheimer's, Menkes, and Wilson diseases.
Brain research bulletin 2001;55(2):175-85.
2001: Jochen Walter; Regina Fluhrer; B Hartung; Michael Willem; Christoph Kaether; Anja Capell; Sven Lammich; Gerd Multhaup; Christian Haass
Phosphorylation regulates intracellular trafficking of beta-secretase.
The Journal of biological chemistry 2001;276(18):14634-41.
2001: Ursula Bodendorf; Frauke Fischer; D Bodian; Gerd Multhaup; Paolo Paganetti
A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein.
The Journal of biological chemistry 2001;276(15):12019-23.
2001: John W M Creemers; D Ines Dominguez; E Plets; Lutgarde Serneels; Neil A Taylor; Gerd Multhaup; Katleen Craessaerts; Willem ANNAERT; Bart De Strooper
Processing of beta-secretase by furin and other members of the proprotein convertase family.
The Journal of biological chemistry 2001;276(6):4211-7.
2001: Thomas A Bayer; Oliver Wirths; K Majtényi; Tobias Hartmann; Gerd Multhaup; Konrad Beyreuther; Christian Czech
Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport.
Brain pathology (Zurich, Switzerland) 2001;11(1):1-11.
2000: Oliver Wirths; S Weickert; K Majtenyi; L Havas; Philipp J Kahle; Masayasu Okochi; Christian Haass; Gerd Multhaup; Konrad Beyreuther; Thomas A Bayer
Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques.
Neuroreport 2000;11(17):3737-41.
2000: Anja Capell; Harald Steiner; Michael Willem; H Kaiser; C Meyer; Jochen Walter; Sven Lammich; Gerd Multhaup; Christian Haass
Maturation and pro-peptide cleavage of beta-secretase.
The Journal of biological chemistry 2000;275(40):30849-54.
2000: Robert A Cherny; Kevin J Barnham; T Lynch; Irene Volitakis; Qiao-Xin Li; Catriona A McLean; Gerd Multhaup; Konrad Beyreuther; Rudolph E Tanzi; Colin L Masters; Ashley I Bush
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.
Journal of structural biology 2000;130(2-3):209-16.
2000: Thilo Borchardt; C Schmidt; J Camarkis; Roberto Cappai; Colin L Masters; Konrad Beyreuther; Gerd Multhaup
Differential effects of zinc on amyloid precursor protein (APP) processing in copper-resistant variants of cultured Chinese hamster ovary cells.
Cellular and molecular biology (Noisy-le-Grand, France) 2000;46(4):785-95.
2000: L Kulic; Jochen Walter; Gerd Multhaup; David B Teplow; Ralf Baumeister; H Romig; Anja Capell; Harald Steiner; Christian Haass
Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5913-8.
2000: Stephan Urban; C Schwarz; U C Marx; H Zentgraf; Heinz Schaller; Gerd Multhaup
Receptor recognition by a hepatitis B virus reveals a novel mode of high affinity virus-receptor interaction.
The EMBO journal 2000;19(6):1217-27.
1999: Xudong Huang; Math P Cuajungco; Craig S Atwood; Mariana A Hartshorn; J D Tyndall; G R Hanson; K C Stokes; M Leopold; Gerd Multhaup; Lee E Goldstein; RC Scarpa; Aleister J Saunders; J Lim; Robert D. Moir; C Glabe; E F Bowden; Colin L Masters; D P Fairlie; Rudolph E Tanzi; Ashley I Bush
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.
The Journal of biological chemistry 1999;274(52):37111-6.
1999: Thilo Borchardt; James Camakaris; Roberto Cappai; Colin L Masters; Konrad Beyreuther; Gerd Multhaup
Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion.
The Biochemical journal 1999;344 Pt 2():461-7.
1999: T A Bayer; Roberto Cappai; Colin L Masters; Konrad Beyreuther; Gerd Multhaup
It all sticks together--the APP-related family of proteins and Alzheimer's disease.
Molecular psychiatry 1999;4(6):524-8.
1999: Anthony R White; Gerd Multhaup; Fran Maher; Shayne A Bellingham; James Camakaris; Hui Zheng; Ashley I Bush; Konrad Beyreuther; Colin L Masters; Roberto Cappai
The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(21):9170-9.
1999: Anthony R White; R Reyes; Julian F B Mercer; James Camakaris; Hui Zheng; Ashley I Bush; Gerd Multhaup; Konrad Beyreuther; Colin L Masters; Roberto Cappai
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice.
Brain research 1999;842(2):439-44.
1999: Stefan F Lichtenthaler; Gerd Multhaup; Colin L Masters; Konrad Beyreuther
A novel substrate for analyzing Alzheimer's disease gamma-secretase.
FEBS letters 1999;453(3):288-92.
1999: Xudong Huang; Craig S Atwood; Mariana A Hartshorn; Gerd Multhaup; Lee E Goldstein; RC Scarpa; Math P Cuajungco; D N Gray; J Lim; Robert D. Moir; Rudolph E Tanzi; Ashley I Bush
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.
Biochemistry 1999;38(24):7609-16.
1999: Jamie Rossjohn; Roberto Cappai; Susanne C Feil; A Henry; William J McKinstry; Denise Galatis; L Hesse; Gerd Multhaup; Konrad Beyreuther; Colin L Masters; Michael W Parker
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.
Nature structural biology 1999;6(4):327-31.
1999: Dirk Beher; C Elle; J Underwood; John B Davis; R Ward; EH Karran; Colin L Masters; Konrad Beyreuther; Gerd Multhaup
Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain.
Journal of neurochemistry 1999;72(4):1564-73.
1999: Stephan Urban; C Kruse; Gerd Multhaup
A soluble form of the avian hepatitis B virus receptor. Biochemical characterization and functional analysis of the receptor ligand complex.
The Journal of biological chemistry 1999;274(9):5707-15.
1999: R Egensperger; Sascha Weggen; N Ida; Gerd Multhaup; R Schnabel; Konrad Beyreuther; Thomas A Bayer
Reverse relationship between beta-amyloid precursor protein and beta-amyloid peptide plaques in Down's syndrome versus sporadic/familial Alzheimer's disease.
Acta neuropathologica 1999;97(2):113-8.
1999: Gerd Multhaup; Colin L Masters
Metal binding and radical generation of proteins in human neurological diseases and aging.
Metal ions in biological systems 1999;36():365-87.
1999: Gerd Multhaup; L Hesse; Thilo Borchardt; Thomas Ruppert; Roberto Cappai; Colin L Masters; Konrad Beyreuther
Autoxidation of amyloid precursor protein and formation of reactive oxygen species.
Advances in experimental medicine and biology 1999;448():183-92.
1998: A Henry; Qiao-Xin Li; Denise Galatis; L Hesse; Gerd Multhaup; Konrad Beyreuther; Colin L Masters; Roberto Cappai
Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein.
British journal of haematology 1998;103(2):402-15.
1998: Anthony R White; Hui Zheng; Denise Galatis; Fran Maher; L Hesse; Gerd Multhaup; Konrad Beyreuther; Colin L Masters; Roberto Cappai
Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(16):6207-17.
1998: Thomas Ilg; David J Craik; Graeme Currie; Gerd Multhaup; Antony Bacic
Stage-specific proteophosphoglycan from Leishmania mexicana amastigotes. Structural characterization of novel mono-, di-, and triphosphorylated phosphodiester-linked oligosaccharides.
The Journal of biological chemistry 1998;273(22):13509-23.
1998: Gerd Multhaup; Thomas Ruppert; Andrea Schlicksupp; L Hesse; E Bill; Rüdiger Pipkorn; Colin L Masters; Konrad Beyreuther
Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide.
Biochemistry 1998;37(20):7224-30.
1998: Robert D. Moir; T Lynch; Ashley I Bush; S Whyte; A Henry; S Portbury; Gerd Multhaup; David Small; Rudolph E Tanzi; Konrad Beyreuther; Colin L Masters
Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.
The Journal of biological chemistry 1998;273(9):5013-9.
1997: Stefan F Lichtenthaler; N Ida; Gerd Multhaup; Colin L Masters; Konrad Beyreuther
Mutations in the transmembrane domain of APP altering gamma-secretase specificity.
Biochemistry 1997;36(49):15396-403.
1997: Thomas A Bayer; Krzysztof Paliga; Sascha Weggen; Otmar D Wiestler; Konrad Beyreuther; Gerd Multhaup
Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer's disease.
Acta neuropathologica 1997;94(6):519-24.
1997: Krzysztof Paliga; G Peraus; Sylvia Kreger; U Dürrwang; L Hesse; Gerd Multhaup; Colin L Masters; Konrad Beyreuther; Andreas Weidemann
Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid.
European journal of biochemistry / FEBS 1997;250(2):354-63.
1997: Gerd Multhaup; Thomas Ruppert; Andrea Schlicksupp; L Hesse; Dirk Beher; Colin L Masters; Konrad Beyreuther
Reactive oxygen species and Alzheimer's disease.
Biochemical pharmacology 1997;54(5):533-9.
1997: Jochen Walter; J Grünberg; Anja Capell; B Pesold; A Schindzielorz; Martin Citron; Klaus Mendla; Peter St George-Hyslop; Gerd Multhaup; Dennis J Selkoe; Christian Haass
Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5349-54.
1997: P J Tienari; N Ida; E Ikonen; M Simons; Andreas Weidemann; Gerd Multhaup; Colin L Masters; C G Dotti; Konrad Beyreuther
Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):4125-30.
1997: Gerd Multhaup
Amyloid precursor protein, copper and Alzheimer's disease.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1997;51(3):105-11.
1996: Gerd Multhaup
Response: Alzheimer's Precursor Protein and the Use of Bathocuproine for Determining Reduction of Copper(II).
Science (New York, N.Y.) 1996;274(5294):1934.
1996: P J Tienari; Bart De Strooper; E Ikonen; M Simons; Andreas Weidemann; C Czech; Tobias Hartmann; N Ida; Gerd Multhaup; Colin L Masters; Fred Van Leuven; Konrad Beyreuther; Carlos G Dotti
The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein.
The EMBO journal 1996;15(19):5218-29.
1996: Tobias Hartmann; C Bergsdorf; R Sandbrink; P J Tienari; Gerd Multhaup; N Ida; S Bieger; T Dyrks; Andreas Weidemann; Colin L Masters; Konrad Beyreuther
Alzheimer's disease betaA4 protein release and amyloid precursor protein sorting are regulated by alternative splicing.
The Journal of biological chemistry 1996;271(22):13208-14.
1996: Gerd Multhaup; Andrea Schlicksupp; L Hesse; Dirk Beher; T Ruppert; Colin L Masters; Konrad Beyreuther
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)
Science (New York, N.Y.) 1996;271(5254):1406-9.
1996: J Gamer; Gerd Multhaup; Toshifumi Tomoyasu; J S McCarty; Stefan Rüdiger; H J Schönfeld; C Schirra; Hermann Bujard; Bernd Bukau
A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32.
The EMBO journal 1996;15(3):607-17.
1996: M Simons; Bart De Strooper; Gerd Multhaup; P J Tienari; Carlos G Dotti; Konrad Beyreuther
Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(3):899-908.
1996: Dirk Beher; L Hesse; Colin L Masters; Gerd Multhaup
Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.
The Journal of biological chemistry 1996;271(3):1613-20.
1996: Konrad Beyreuther; Gerd Multhaup; U Mönning; R Sandbrink; Dirk Beher; L Hesse; David Small; Colin L Masters
Regulation of APP expression, biogenesis and metabolism by extracellular matrix and cytokines.
Annals of the New York Academy of Sciences 1996;777():74-6.
1996: Konrad Beyreuther; Gerd Multhaup; Colin L Masters
Alzheimer's disease: genesis of amyloid.
Ciba Foundation symposium 1996;199():119-27; discussion 127-31.
1995: Bart De Strooper; M Simons; Gerd Multhaup; Fred Van Leuven; Konrad Beyreuther; Carlos G Dotti
Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.
The EMBO journal 1995;14(20):4932-8.
1995: Gerd Multhaup; H Mechler; Colin L Masters
Characterization of the high affinity heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP) and its enhancement by zinc(II).
Journal of molecular recognition : JMR 1995;8(4):247-57.
1995: Qiao-Xin Li; Geneviève Evin; David Small; Gerd Multhaup; Konrad Beyreuther; Colin L Masters
Proteolytic processing of Alzheimer's disease beta A4 amyloid precursor protein in human platelets.
The Journal of biological chemistry 1995;270(23):14140-7.
1994: Gerd Multhaup; Ashley I Bush; P Pollwein; Colin L Masters
Interaction between the zinc (II) and the heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP).
FEBS letters 1994;355(2):151-4.
1994: Ashley I Bush; Warren H Pettingell; Gerd Multhaup; M d Paradis; J P Vonsattel; James Gusella; Konrad Beyreuther; Colin L Masters; Rudolph E Tanzi
Rapid induction of Alzheimer A beta amyloid formation by zinc.
Science (New York, N.Y.) 1994;265(5177):1464-7.
1994: L Hesse; Dirk Beher; Colin L Masters; Gerd Multhaup
The beta A4 amyloid precursor protein binding to copper.
FEBS letters 1994;349(1):109-16.
1994: B Boes; Hartmut Hengel; T Ruppert; Gerd Multhaup; Ulrich H Koszinowski; Peter-M Kloetzel
Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes.
The Journal of experimental medicine 1994;179(3):901-9.
1994: Gerd Multhaup
Identification and regulation of the high affinity binding site of the Alzheimer's disease amyloid protein precursor (APP) to glycosaminoglycans.
Biochimie 1994;76(3-4):304-11.
1993: Anna Seelig; Gerd Multhaup; B Pesold-Hurt; Konrad Beyreuther; Peter-M Kloetzel
Drosophila proteasome Dm25 subunit substitutes the mouse MC3 subunit in hybrid proteasomes. The N-terminal domain is essential for subunit incorporation.
The Journal of biological chemistry 1993;268(34):25561-7.
1993: Konrad Beyreuther; P Pollwein; Gerd Multhaup; U Mönning; G König; T Dyrks; W Schubert; Colin L Masters
Regulation and expression of the Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome.
Annals of the New York Academy of Sciences 1993;695():91-102.
1993: Ashley I Bush; Gerd Multhaup; Robert D. Moir; T G Williamson; David Small; B Rumble; P Pollwein; Konrad Beyreuther; Colin L Masters
A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease.
The Journal of biological chemistry 1993;268(22):16109-12.
1993: Gerd Multhaup; Colin L Masters; Konrad Beyreuther
A molecular approach to Alzheimer's disease.
Biological chemistry Hoppe-Seyler 1993;374(1):1-8.
1992: Robert D. Moir; Ralph N Martins; Ashley I Bush; David Small; E A Milward; B A Rumble; Gerd Multhaup; Konrad Beyreuther; Colin L Masters
Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization.
Journal of neurochemistry 1992;59(4):1490-8.
1992: P Prior; B Schmitt; G Grenningloh; I Pribilla; Gerd Multhaup; Konrad Beyreuther; Y Maulet; P Werner; D Langosch; Joachim Kirsch
Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein.
Neuron 1992;8(6):1161-70.
1992: K Ziegelbauer; Gerd Multhaup; Peter Overath
Molecular characterization of two invariant surface glycoproteins specific for the bloodstream stage of Trypanosoma brucei.
The Journal of biological chemistry 1992;267(15):10797-803.
1992: Konrad Beyreuther; T Dyrks; C Hilbich; U Mönning; G König; Gerd Multhaup; P Pollwein; Colin L Masters
Amyloid precursor protein (APP) and beta A4 amyloid in Alzheimer's disease and Down syndrome.
Progress in clinical and biological research 1992;379():159-82.
1991: A Schumacher; H Schröter; Gerd Multhaup; Alfred Nordheim
Murine cyclophilin-S1: a variant peptidyl-prolyl isomerase with a putative signal sequence expressed in differentiating F9 cells.
Biochimica et biophysica acta 1991;1129(1):13-22.
1991: W Schubert; R Prior; Andreas Weidemann; Heinrich Dircksen; Gerd Multhaup; Colin L Masters; Konrad Beyreuther
Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites.
Brain research 1991;563(1-2):184-94.
1991: Konrad Beyreuther; Ashley I Bush; T Dyrks; C Hilbich; G König; U Mönning; Gerd Multhaup; R Prior; B Rumble; W Schubert
Mechanisms of amyloid deposition in Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():129-39.
1990: Pari Malherbe; A Draguhn; Gerd Multhaup; Konrad Beyreuther; H Möhler
GABAA-receptor expressed from rat brain alpha- and beta-subunit cDNAs displays potentiation by benzodiazepine receptor ligands.
Brain research. Molecular brain research 1990;8(3):199-208.
1990: Christian Haass; B Pesold-Hurt; Gerd Multhaup; Konrad Beyreuther; Peter-M Kloetzel
The Drosophila PROS-28.1 gene is a member of the proteasome gene family.
Gene 1990;90(2):235-41.
1990: G Grenningloh; I Pribilla; P Prior; Gerd Multhaup; Konrad Beyreuther; O Taleb; Heinrich Betz
Cloning and expression of the 58 kd beta subunit of the inhibitory glycine receptor.
Neuron 1990;4(6):963-70.
1990: R A Rupp; U Kruse; Gerd Multhaup; U Göbel; Konrad Beyreuther; Albrecht Sippel
Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes.
Nucleic acids research 1990;18(9):2607-16.
1990: M M Falk; P R Grigera; I E Bergmann; A Zibert; Gerd Multhaup; E Beck
Foot-and-mouth disease virus protease 3C induces specific proteolytic cleavage of host cell histone H3.
Journal of virology 1990;64(2):748-56.
1989: Christian Haass; B Pesold-Hurt; Gerd Multhaup; Konrad Beyreuther; Peter-M Kloetzel
The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome.
The EMBO journal 1989;8(8):2373-9.
1989: B Rumble; R Retallack; C Hilbich; G Simms; Gerd Multhaup; Ralph N Martins; A Hockey; P Montgomery; Konrad Beyreuther; Colin L Masters
Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.
The New England journal of medicine 1989;320(22):1446-52.
1989: H G Lemaire; J M Salbaum; Gerd Multhaup; J Kang; R M Bayney; A Unterbeck; Konrad Beyreuther; Benno Müller-Hill
The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons.
Nucleic acids research 1989;17(2):517-22.
1988: James Hope; L J Reekie; Nora Hunter; Gerd Multhaup; Konrad Beyreuther; H White; A C Scott; Mick J Stack; Michael Dawson; Gerald A H Wells
Fibrils from brains of cows with new cattle disease contain scrapie-associated protein.
Nature 1988;336(6197):390-2.
1988: L Davies; B Wolska; C Hilbich; Gerd Multhaup; Ralph N Martins; G Simms; Konrad Beyreuther; Colin L Masters
A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques.
Neurology 1988;38(11):1688-93.
1988: B D Shivers; C Hilbich; Gerd Multhaup; M Salbaum; Konrad Beyreuther; P H Seeburg
Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.
The EMBO journal 1988;7(5):1365-70.
1988: T Dyrks; Andreas Weidemann; Gerd Multhaup; J M Salbaum; H G Lemaire; J Kang; Benno Müller-Hill; Colin L Masters; Konrad Beyreuther
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.
The EMBO journal 1988;7(4):949-57.
1988: James Hope; Gerd Multhaup; L J Reekie; R H Kimberlin; Konrad Beyreuther
Molecular pathology of scrapie-associated fibril protein (PrP) in mouse brain affected by the ME7 strain of scrapie.
European journal of biochemistry / FEBS 1988;172(2):271-7.
1988: K Zimmermann; T Herget; J M Salbaum; W Schubert; C Hilbich; M Cramer; Colin L Masters; Gerd Multhaup; J Kang; H G Lemaire
Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle.
The EMBO journal 1988;7(2):367-72.
1988: Georg Herrler; Gerd Multhaup; Konrad Beyreuther; Hans-Dieter Klenk
Serine 71 of the glycoprotein HEF is located at the active site of the acetylesterase of influenza C virus.
Archives of virology 1988;102(3-4):269-74.
1987: DON GUIROY; M Miyazaki; Gerd Multhaup; P Fischer; R M Garruto; Konrad Beyreuther; Colin L Masters; G Simms; CJ Gibbs; D Carleton Gajdusek
Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(7):2073-7.
1987: J Kang; H G Lemaire; A Unterbeck; J M Salbaum; Colin L Masters; K H Grzeschik; Gerd Multhaup; Konrad Beyreuther; Benno Müller-Hill
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
Nature 1987;325(6106):733-6.
1986: J Hope; L J Morton; C F Farquhar; Gerd Multhaup; Konrad Beyreuther; R H Kimberlin
The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP).
The EMBO journal 1986;5(10):2591-7.
1986: Silvano Riva; C Morandi; P Tsoulfas; M Pandolfo; Giuseppe Biamonti; B Merrill; K R Williams; Gerd Multhaup; Konrad Beyreuther; H Werr
Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1.
The EMBO journal 1986;5(9):2267-73.
1985: Colin L Masters; Gerd Multhaup; G Simms; J Pottgiesser; Ralph N Martins; Konrad Beyreuther
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.
The EMBO journal 1985;4(11):2757-63.
1985: Colin L Masters; G Simms; N A Weinman; Gerd Multhaup; B L McDonald; Konrad Beyreuther
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(12):4245-9.
1985: Gerd Multhaup; H Diringer; H Hilmert; H Prinz; J Heukeshoven; Konrad Beyreuther
The protein component of scrapie-associated fibrils is a glycosylated low molecular weight protein.
The EMBO journal 1985;4(6):1495-501.