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Gabriele Multhoff

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
15
Botzler, C
15
Issels, Rolf
12
Gehrmann, Mathias
10
Pfister, Karin
9
Gross, Catharina
8
Eissner, Günther
7
Gastpar, Robert
5
Ellwart, Joachim
5
Hiddemann, Wolfgang
4
Pockley, Graham
4
Radons, Jürgen
3
Molls, Michael
3
Rossbacher, Lydia
3
Hantschel, Markus
3
Thonigs, Gerald

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Publications

TOP 3
Pockley A Graham; Calderwood Stuart K; Multhoff Gabriele
The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?
Schilling Daniela; Gehrmann Mathias; Steinem Claudia; De Maio Antonio; Pockley Alan G; Abend Michael; Molls Michael; Multhoff Gabriele
Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells.
Multhoff Gabriele
Hyperthermia classic commentary: Activation of natural killer (NK) cells by heat shock protein 70, Gabriele Multhoff, International Journal of Hyperthermia, 2002;18:576-585.

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All Publications

2009: Pockley A Graham; Calderwood Stuart K; Multhoff Gabriele
The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?
Cell stress & chaperones 2009;14(6):545-53.
2009: Schilling Daniela; Gehrmann Mathias; Steinem Claudia; De Maio Antonio; Pockley Alan G; Abend Michael; Molls Michael; Multhoff Gabriele
Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(8):2467-77.
2009: Multhoff Gabriele
Hyperthermia classic commentary: Activation of natural killer (NK) cells by heat shock protein 70, Gabriele Multhoff, International Journal of Hyperthermia, 2002;18:576-585.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2009;25(3):176-9.
2009: Multhoff Gabriele
Activation of natural killer cells by heat shock protein 70. 2002.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2009;25(3):169-75.
2009: Milani Valeria; Stangl Stefan; Issels Rolf; Gehrmann Mathias; Wagner Beate; Hube Kathrin; Mayr Doris; Hiddemann Wolfgang; Molls Michael; Multhoff Gabriele
Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy--a case report.
Journal of translational medicine 2009;7():50.
2008: Kraetzel K; Stoelcker B; Eissner G; Multhoff G; Pfeifer M; Holler E; Schulz C
NKG2D-dependent effector function of bronchial epithelium-activated alloreactive T-cells.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(3):563-70.
2008: Horváth Ibolya; Multhoff Gabriele; Sonnleitner Alois; Vígh László
Membrane-associated stress proteins: more than simply chaperones.
Biochimica et biophysica acta 2008;1778(7-8):1653-64.
2008: Gross Catharina; Holler Ernst; Stangl Stefan; Dickinson Anne; Pockley A Graham; Asea Alexzander A; Mallappa Nagaraja; Multhoff Gabriele
An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation.
Leukemia research 2008;32(4):527-34.
2008: Vega Virginia L; Rodríguez-Silva Monica; Frey Tiffany; Gehrmann Mathias; Diaz Juan Carlos; Steinem Claudia; Multhoff Gabriele; Arispe Nelson; De Maio Antonio
Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):4299-307.
2008: Stangl Stefan; Gross Catharina; Pockley Alan G; Asea Alexzander A; Multhoff Gabriele
Influence of Hsp70 and HLA-E on the killing of leukemic blasts by cytokine/Hsp70 peptide-activated human natural killer (NK) cells.
Cell stress & chaperones 2008;13(2):221-30.
2008: Pockley A Graham; Multhoff Gabriele
Cell stress proteins in extracellular fluids: friend or foe?
Novartis Foundation symposium 2008;291():86-95; discussion 96-100, 137-40.
2008: Gehrmann Mathias; Liebisch Gerhard; Schmitz Gerd; Anderson Robin; Steinem Claudia; De Maio Antonio; Pockley Graham; Multhoff Gabriele
Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3.
PloS one 2008;3(4):e1925.
2008: Gehrmann Mathias; Radons Jürgen; Molls Michael; Multhoff Gabriele
The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells.
Cell stress & chaperones 2008;13(1):1-10.
2007: Multhoff Gabriele
Heat shock protein 70 (Hsp70): membrane location, export and immunological relevance.
Methods (San Diego, Calif.) 2007;43(3):229-37.
2007: Sherman Michael; Multhoff Gabriele
Heat shock proteins in cancer.
Annals of the New York Academy of Sciences 2007;1113():192-201.
2007: Elsner Leslie; Muppala Vijayakumar; Gehrmann Mathias; Lozano Jingky; Malzahn Dörthe; Bickeböller Heike; Brunner Edgar; Zientkowska Marta; Herrmann Thomas; Walter Lutz; Alves Frauke; Multhoff Gabriele; Dressel Ralf
The heat shock protein HSP70 promotes mouse NK cell activity against tumors that express inducible NKG2D ligands.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5523-33.
2007: Pfister Karin; Radons Jürgen; Busch Raymonde; Tidball James G; Pfeifer Michael; Freitag Lutz; Feldmann Horst-Jürgen; Milani Valeria; Issels Rolf; Multhoff Gabriele
Patient survival by Hsp70 membrane phenotype: association with different routes of metastasis.
Cancer 2007;110(4):926-35.
2007: Schmitt E; Gehrmann M; Brunet M; Multhoff G; Garrido C
Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy.
Journal of leukocyte biology 2007;81(1):15-27.
2007: Bogunia-Kubik Katarzyna; Multhoff Gabriele
Investigating cellular stress responses--a multidisciplinary approach from basic science to therapeutics--report on the EuroSciCon (European Scientific Conferences) meeting.
Cell stress & chaperones 2007;12(2):106-11.
2006: Brockmöller Jürgen; Junker Klaus; Multhoff Gabriele
[New perspectives in the management of non-small-cell lung carcinoma (NSCLC)]
Onkologie 2006;29 Suppl 2():25-8.
2006: Stangl Stefan; Wortmann Andreas; Guertler Ulrich; Multhoff Gabriele
Control of metastasized pancreatic carcinomas in SCID/beige mice with human IL-2/TKD-activated NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6270-6.
2006: Multhoff Gabriele; De Maio Antonio
Stress down south: meeting report of the fifth International Workshop on the Molecular Biology of Stress Responses.
Cell stress & chaperones 2006;11(2):108-15.
2005: Bausero Maria A; Gastpar Robert; Multhoff Gabriele; Asea Alexzander
Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):2900-12.
2005: Radons Jürgen; Gross Catharina; Stangl Stefan; Multhoff Gabriele
Nucleofection of non-B cells with mini-Epstein-Barr virus DNA.
Journal of immunological methods 2005;303(1-2):135-41.
2005: Gastpar Robert; Gehrmann Mathias; Bausero Maria A; Asea Alexzander; Gross Catharina; Schroeder Josef A; Multhoff Gabriele
Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells.
Cancer research 2005;65(12):5238-47.
2005: Gehrmann M; Marienhagen J; Eichholtz-Wirth H; Fritz E; Ellwart J; Jäättelä M; Zilch T; Multhoff G
Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells.
Cell death and differentiation 2005;12(1):38-51.
2005: Radons Jürgen; Multhoff Gabriele
Immunostimulatory functions of membrane-bound and exported heat shock protein 70.
Exercise immunology review 2005;11():17-33.
2005: Gehrmann Mathias; Schönberger Johann; Zilch Tanja; Rossbacher Lydia; Thonigs Gerald; Eilles Christoph; Multhoff Gabriele
Retinoid- and sodium-butyrate-induced decrease in heat shock protein 70 membrane-positive tumor cells is associated with reduced sensitivity to natural killer cell lysis, growth delay, and altered growth morphology.
Cell stress & chaperones 2005;10(2):136-46.
2004: Lechin Fuad; van der Dijs Bertha; Lechin Alex E; Multhoff Gabriele; Pfister Karin; Hromadnikova Ilona; Zlacka Denisa
Natural killer cells activity and neuroimmunological treatment of cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(23):8120; author reply 8120-1.
2004: Nylandsted Jesper; Gyrd-Hansen Mads; Danielewicz Agnieszka; Fehrenbacher Nicole; Lademann Ulrik; Høyer-Hansen Maria; Weber Ekkehard; Multhoff Gabriele; Rohde Mikkel; Jäättelä Marja
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.
The Journal of experimental medicine 2004;200(4):425-35.
2004: Krause Stefan W; Gastpar Robert; Andreesen Reinhard; Gross Catharina; Ullrich Heidrun; Thonigs Gerald; Pfister Karin; Multhoff Gabriele
Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase i trial.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(11):3699-707.
2004: Gehrmann Mathias; Brunner Marion; Pfister Karin; Reichle Albrecht; Kremmer Elisabeth; Multhoff Gabriele
Differential up-regulation of cytosolic and membrane-bound heat shock protein 70 in tumor cells by anti-inflammatory drugs.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(10):3354-64.
2004: Becker B; Multhoff G; Farkas B; Wild P-J; Landthaler M; Stolz W; Vogt T
Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases.
Experimental dermatology 2004;13(1):27-32.
2004: Gastpar Robert; Gross Catharina; Rossbacher Lydia; Ellwart Joachim; Riegger Julia; Multhoff Gabriele
The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):972-80.
2003: Kleinjung Tobias; Arndt Olaf; Feldmann Horst Jürgen; Bockmühl Ulrike; Gehrmann Mathias; Zilch Tanja; Pfister Karin; Schönberger Johannes; Marienhagen Jörg; Eilles Christoph; Rossbacher Lydia; Multhoff Gabriele
Heat shock protein 70 (Hsp70) membrane expression on head-and-neck cancer biopsy-a target for natural killer (NK) cells.
International journal of radiation oncology, biology, physics 2003;57(3):820-6.
2003: Gross Catharina; Koelch Walter; DeMaio Antonio; Arispe Nelson; Multhoff Gabriele
Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.
The Journal of biological chemistry 2003;278(42):41173-81.
2003: Farkas Beatrix; Hantschel Markus; Magyarlaki Marta; Becker Bernd; Scherer Kathrin; Landthaler Michael; Pfister Karin; Gehrmann Mathias; Gross Catharina; Mackensen Andreas; Multhoff Gabriele
Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma.
Melanoma research 2003;13(2):147-52.
2003: Gehrmann Mathias; Schmetzer Helga; Eissner Günther; Haferlach Torsten; Hiddemann Wolfgang; Multhoff Gabriele
Membrane-bound heat shock protein 70 (Hsp70) in acute myeloid leukemia: a tumor specific recognition structure for the cytolytic activity of autologous NK cells.
Haematologica 2003;88(4):474-6.
2003: Gross Catharina; Hansch Daniel; Gastpar Robert; Multhoff Gabriele
Interaction of heat shock protein 70 peptide with NK cells involves the NK receptor CD94.
Biological chemistry 2003;384(2):267-79.
2003: Gross Catharina; Schmidt-Wolf Ingo G H; Nagaraj Srinivas; Gastpar Robert; Ellwart Joachim; Kunz-Schughart Leoni A; Multhoff Gabriele
Heat shock protein 70-reactivity is associated with increased cell surface density of CD94/CD56 on primary natural killer cells.
Cell stress & chaperones 2003;8(4):348-60.
2002: Gehrmann Mathias; Pfister Karin; Hutzler Peter; Gastpar Robert; Margulis Boris; Multhoff Gabriele
Effects of antineoplastic agents on cytoplasmic and membrane-bound heat shock protein 70 (Hsp70) levels.
Biological chemistry 2002;383(11):1715-25.
2002: Moser Christian; Schmidbauer Christin; Gürtler Ulrich; Gross Catharina; Gehrmann Mathias; Thonigs Gerald; Pfister Karin; Multhoff Gabriele
Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by heat shock protein 70 (Hsp70)-peptide-activated, CD94 positive natural killer cells.
Cell stress & chaperones 2002;7(4):365-73.
2002: Eissner Günther; Multhoff Gabriele; Gerbitz Armin; Kirchner Silvia; Bauer Sonja; Haffner Silvia; Sondermann Daniela; Andreesen Reinhard; Holler Ernst
Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide.
Blood 2002;100(1):334-40.
2001: Multhoff G; Pfister K; Gehrmann M; Hantschel M; Gross C; Hafner M; Hiddemann W
A 14-mer Hsp70 peptide stimulates natural killer (NK) cell activity.
Cell stress & chaperones 2001;6(4):337-44.
2000: Multhoff G; Pfister K; Botzler C; Jordan A; Scholz R; Schmetzer H; Burgstahler R; Hiddemann W
Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors.
International journal of cancer. Journal international du cancer 2000;88(5):791-7.
2000: Hantschel M; Pfister K; Jordan A; Scholz R; Andreesen R; Schmitz G; Schmetzer H; Hiddemann W; Multhoff G
Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients.
Cell stress & chaperones 2000;5(5):438-42.
1999: Multhoff G; Mizzen L; Winchester C C; Milner C M; Wenk S; Eissner G; Kampinga H H; Laumbacher B; Johnson J
Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells.
Experimental hematology 1999;27(11):1627-36.
1999: Multhoff G; Falk M
Meeting report on the International Congress on Hyperthermia in Clinical Oncology, Venice 1998.
Cell stress & chaperones 1999;4(1):54-9.
1999: Botzler C; Ellwart J; Günther W; Eissner G; Multhoff G
Synergistic effects of heat and ET-18-OCH3 on membrane expression of hsp70 and lysis of leukemic K562 cells.
Experimental hematology 1999;27(3):470-8.
1998: Botzler C; Schmidt J; Luz A; Jennen L; Issels R; Multhoff G
Differential Hsp70 plasma-membrane expression on primary human tumors and metastases in mice with severe combined immunodeficiency.
International journal of cancer. Journal international du cancer 1998;77(6):942-8.
1998: Multhoff G; Botzler C
Heat-shock proteins and the immune response.
Annals of the New York Academy of Sciences 1998;851():86-93.
1998: Botzler C; Li G; Issels R D; Multhoff G
Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response.
Cell stress & chaperones 1998;3(1):6-11.
1998: Multhoff G; Botzler C; Issels R
The role of heat shock proteins in the stimulation of an immune response.
Biological chemistry 1998;379(3):295-300.
1997: Multhoff G; Botzler C; Jennen L; Schmidt J; Ellwart J; Issels R
Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4341-50.
1997: Botzler C; Kis K; Issels R; Multhoff G
A comparison of the effects of ifosfamide vs. mafosfamide treatment on intracellular glutathione levels and immunological functions of immunocompetent lymphocyte subsets.
Experimental hematology 1997;25(4):338-44.
1997: Lindner H; Holler E; Ertl B; Multhoff G; Schreglmann M; Klauke I; Schultz-Hector S; Eissner G
Peripheral blood mononuclear cells induce programmed cell death in human endothelial cells and may prevent repair: role of cytokines.
Blood 1997;89(6):1931-8.
1996: Botzler C; Issels R; Multhoff G
Heat-shock protein 72 cell-surface expression on human lung carcinoma cells in associated with an increased sensitivity to lysis mediated by adherent natural killer cells.
Cancer immunology, immunotherapy : CII 1996;43(4):226-30.
1996: Multhoff G; Hightower L E
Cell surface expression of heat shock proteins and the immune response.
Cell stress & chaperones 1996;1(3):167-76.
1996: Multhoff G; Botzler C; Allenbacher A; Issels R
Effects of ifosfamide on immunocompetent effector cells.
Cancer immunology, immunotherapy : CII 1996;42(4):251-4.
1996: Botzler C; Kolb H J; Issels R D; Multhoff G
Noncytotoxic alkyl-lysophospholipid treatment increases sensitivity of leukemic K562 cells to lysis by natural killer (NK) cells.
International journal of cancer. Journal international du cancer 1996;65(5):633-8.
1995: Eissner G; Kohlhuber F; Grell M; Ueffing M; Scheurich P; Hieke A; Multhoff G; Bornkamm G W; Holler E
Critical involvement of transmembrane tumor necrosis factor-alpha in endothelial programmed cell death mediated by ionizing radiation and bacterial endotoxin.
Blood 1995;86(11):4184-93.
1995: Multhoff G; Botzler C; Wiesnet M; Eissner G; Issels R
CD3- large granular lymphocytes recognize a heat-inducible immunogenic determinant associated with the 72-kD heat shock protein on human sarcoma cells.
Blood 1995;86(4):1374-82.
1995: Multhoff G; Meier T; Botzler C; Wiesnet M; Allenbacher A; Wilmanns W; Issels R D
Differential effects of ifosfamide on the capacity of cytotoxic T lymphocytes and natural killer cells to lyse their target cells correlate with intracellular glutathione levels.
Blood 1995;85(8):2124-31.
1995: Multhoff G; Botzler C; Wiesnet M; Müller E; Meier T; Wilmanns W; Issels R D
A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells.
International journal of cancer. Journal international du cancer 1995;61(2):272-9.
1994: Meier T; Allenbacher A; Mueller E; Multhoff G; Botzler C; Wiesnet M; Issels R
Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by mesna.
Anti-cancer drugs 1994;5(4):403-9.
1993: Issels R D; Meier T H; Müller E; Multhoff G; Wilmanns W
Ifosfamide induced stress response in human lymphocytes.
Molecular aspects of medicine 1993;14(3):281-6.

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