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Francisco Muñoz-Martínez

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Francisco Muñoz-Martínez; Cristina Torres; Santiago Castanys; Francisco Gamarro
CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells.
Francisco Muñoz-Martínez; Cristina Torres; Santiago Castanys; Francisco Gamarro
The anti-tumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across the plasma membrane of human KB carcinoma cells.
Carolina perez reyes; Francisco Muñoz-Martínez; Ivan Rodriguez Torrecillas; Cristina R Mendoza; Francisco Gamarro; Isabel L Bazzocchi; Marvin J Núñez; Leonardo Pardo; Santiago Castanys; Mercedes Campillo; Ignacio A Jiménez
Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance.

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All Publications

2010: Francisco Muñoz-Martínez; Cristina Torres; Santiago Castanys; Francisco Gamarro
CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells.
Biochemical pharmacology 2010;80(6):793-800.
2008: Francisco Muñoz-Martínez; Cristina Torres; Santiago Castanys; Francisco Gamarro
The anti-tumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across the plasma membrane of human KB carcinoma cells.
Biochimica et biophysica acta 2008;1778(2):530-40.
2007: Carolina perez reyes; Francisco Muñoz-Martínez; Ivan Rodriguez Torrecillas; Cristina R Mendoza; Francisco Gamarro; Isabel L Bazzocchi; Marvin J Núñez; Leonardo Pardo; Santiago Castanys; Mercedes Campillo; Ignacio A Jiménez
Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance.
Journal of medicinal chemistry 2007;50(20):4808-17.
2006: José M Pérez-Victoria; Fernando Cortés-Selva; Adriana Parodi-Talice; Boris I Bavchvarov; F Javier Pérez-Victoria; Francisco Muñoz-Martínez; Mathias Maitrejean; M Paola Costi; Denis Barron; Attilio Di Pietro; Santiago Castanys; Francisco Gamarro
Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux.
Antimicrobial agents and chemotherapy 2006;50(9):3102-10.
2006: Francisco Muñoz-Martínez; Carolina perez reyes; Antonio L Pérez-Lomas; Ignacio A Jiménez; Francisco Gamarro; Santiago Castanys
Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein.
Biochimica et biophysica acta 2006;1758(1):98-110.
2005: Francisco Muñoz-Martínez; Cristina R Mendoza; Isabel L Bazzocchi; Santiago Castanys; Ignacio A Jiménez; Francisco Gamarro
Reversion of human Pgp-dependent multidrug resistance by new sesquiterpenes from Zinowiewia costaricensis.
Journal of medicinal chemistry 2005;48(13):4266-75.
2005: Abdelhakim Ahmed-Belkacem; Alexandre Pozza; Francisco Muñoz-Martínez; Susan E Bates; Santiago Castanys; Francisco Gamarro; Attilio Di Pietro; José M Pérez-Victoria
Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.
Cancer research 2005;65(11):4852-60.
2005: Fernando Cortés-Selva; Francisco Muñoz-Martínez; Attila Iliás; Antonio Ignacio Jiménez; András Váradi; Francisco Gamarro; Santiago Castanys
Functional expression of a multidrug P-glycoprotein transporter of Leishmania.
Biochemical and biophysical research communications 2005;329(2):502-7.
2004: Francisco Muñoz-Martínez; Peihua Lu; Fernando Cortés-Selva; José M Pérez-Victoria; Ignacio A Jiménez; Angel G Ravelo; Frances Sharom; Francisco Gamarro; Santiago Castanys
Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.
Cancer research 2004;64(19):7130-8.