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Eduardo Muñoz

Research Profile

Anatomy

Chemicals & Drugs

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HIV-1

Physiology

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Publications

TOP 3
Moisés Pérez; M Lienhard Schmitz; Inés Zapico; Carmen García-Limones; Anabel Marina; Eduardo Muñoz; Marco A Calzado
Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways.
Alejandro Vallejo; Javier Zamora; Eduardo Muñoz; María A Muñoz-Fernandez; María J Perez-Elias; María Abad-Fernandez; Laura Diaz; Fernando Dronda; Carolina Gutierrez; Beatriz Hernandez-Novoa; Nadia Madrid; Santiago Moreno
The effect of intensification with raltegravir on the HIV-1 reservoir of latently infected memory CD4 T cells in suppressed patients.
Edurne Gallastegui; Josep M Gatell; Carmen Alvarez-Fernández; Juan A Collado; Neus Luque; Brett Marshall; Jordi Mestres; Eduardo Muñoz; Gonzalo Sanchez-Duffhues; Sonsoles Sánchez-Palomino; Jean-Michel Terme; Eric Verdin; David Vidal; Albert Jordan
Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1.

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All Publications

2012: Moisés Pérez; M Lienhard Schmitz; Inés Zapico; Carmen García-Limones; Anabel Marina; Eduardo Muñoz; Marco A Calzado
Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways.
Journal of molecular cell biology 2012;4(5):316-30.
2012: Alejandro Vallejo; Javier Zamora; Eduardo Muñoz; María A Muñoz-Fernandez; María J Perez-Elias; María Abad-Fernandez; Laura Diaz; Fernando Dronda; Carolina Gutierrez; Beatriz Hernandez-Novoa; Nadia Madrid; Santiago Moreno
The effect of intensification with raltegravir on the HIV-1 reservoir of latently infected memory CD4 T cells in suppressed patients.
AIDS (London, England) 2012;26(15):1885-94.
2012: Edurne Gallastegui; Josep M Gatell; Carmen Alvarez-Fernández; Juan A Collado; Neus Luque; Brett Marshall; Jordi Mestres; Eduardo Muñoz; Gonzalo Sanchez-Duffhues; Sonsoles Sánchez-Palomino; Jean-Michel Terme; Eric Verdin; David Vidal; Albert Jordan
Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1.
Journal of virology 2012;86(7):3795-808.
2012: Dionisio A Olmedo; Rocío Sancho; José Alcamí; Luis M Bedoya; Esther del Olmo; Mahabir P Gupta; José L López-Pérez; Eduardo Muñoz; Arturo San Feliciano
3-Phenylcoumarins as inhibitors of HIV-1 replication.
Molecules (Basel, Switzerland) 2012;17(8):9245-57.
2011: Federica Pollastro; Orazio Taglialatela-Scafati; Marco Allarà; Luciano De Petrocellis; Vincenzo Di Marzo; Eduardo Muñoz; Giovani Appendino
Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa).
Journal of natural products 2011;74(9):2019-22.
2011: Gonzalo Sánchez-Duffhues; Minh Q Vo; Moisés Pérez; Marco A Calzado; Santiago Moreno; Giovanni Appendino; Eduardo Muñoz
Activation of latent HIV-1 expression by protein kinase C agonists. A novel therapeutic approach to eradicate HIV-1 reservoirs.
Current drug targets 2011;12(3):348-56.
2010: Moisés Pérez; Amaya García de Vinuesa; Gonzalo Sanchez-Duffhues; Nieves Marquez; M Luz Bellido; M Angeles Muñoz-Fernandez; Santiago Moreno; Trevor P Castor; Marco A Calzado; Eduardo Muñoz
Bryostatin-1 synergizes with histone deacetylase inhibitors to reactivate HIV-1 from latency.
Current HIV research 2010;8(6):418-29.
2010: Carmen M Navarrete; Moisés Pérez; Amaya García de Vinuesa; Juan A Collado; Bernd L Fiebich; Marco A Calzado; Eduardo Muñoz
Endogenous N-acyl-dopamines induce COX-2 expression in brain endothelial cells by stabilizing mRNA through a p38 dependent pathway.
Biochemical pharmacology 2010;79(12):1805-14.
2010: Alberto Pagani; Carmen Navarrete; Bernd L Fiebich; Eduardo Muñoz; Giovanni Appendino
Synthesis and biological evaluation of 12-aminoacylphorboids.
Journal of natural products 2010;73(3):447-51.
2010: Anna Aiello; Ernesto Fattorusso; Paolo Luciano; Marialuisa Menna; Marco A Calzado; Eduardo Muñoz; Francesco Bonadies; Marcella Guiso; Maria Filomena Sanasi; Gianfranco Cocco; Rosario Nicoletti
Synthesis of structurally simplified analogues of aplidinone A, a pro-apoptotic marine thiazinoquinone.
Bioorganic & medicinal chemistry 2010;18(2):719-27.
2009: Marco A Calzado; Laureano de la Vega; Eduardo Muñoz; M Lienhard Schmitz
Autoregulatory control of the p53 response by Siah-1L-mediated HIPK2 degradation.
Biological chemistry 2009;390(10):1079-83.
2009: Gonzalo Sánchez-Duffhues; Marco A Calzado; Amaya García de Vinuesa; Giovanni Appendino; Bernd L Fiebich; Ulich Loock; Annette Lefarth-Risse; Karsten Krohn; Eduardo Muñoz
Denbinobin inhibits nuclear factor-kappaB and induces apoptosis via reactive oxygen species generation in human leukemic cells.
Biochemical pharmacology 2009;77(8):1401-9.
2009: Carmen M Navarrete; Bernd L Fiebich; Amaya García de Vinuesa; Sandra Hess; Antonio Carlos Pinheiro de Oliveira; Eduardo Candelario-Jalil; Francisco J Caballero; Marco A Calzado; Eduardo Muñoz
Opposite effects of anandamide and N-arachidonoyl dopamine in the regulation of prostaglandin E and 8-iso-PGF formation in primary glial cells.
Journal of neurochemistry 2009;109(2):452-64.
2008: Gonzalo Sánchez-Duffhues; Marco A Calzado; Amaya García de Vinuesa; Francisco J Caballero; Abdellah Ech-Chahad; Giovanni Appendino; Karsten Krohn; Bernd L Fiebich; Eduardo Muñoz
Denbinobin, a naturally occurring 1,4-phenanthrenequinone, inhibits HIV-1 replication through an NF-kappaB-dependent pathway.
Biochemical pharmacology 2008;76(10):1240-50.
2008: Nieves Márquez; Marco A Calzado; Gonzalo Sánchez-Duffhues; Moisés Pérez; Alberto Minassi; Alberto Pagani; Giovanni Appendino; Laura Diaz; Maria Angeles Muñoz-Fernández; Eduardo Muñoz
Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation.
Biochemical pharmacology 2008;75(6):1370-80.
2007: Laureano de la Vega; Gonzalo Sánchez-Duffhues; Manuel Fresno; M Lienhard Schmitz; Eduardo Muñoz; Marco A Calzado
The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein.
Journal of molecular biology 2007;372(2):317-30.
2007: Anna Aiello; Ernesto Fattorusso; Antonella Giordano; Marialuisa Menna; Carmen Navarrete; Eduardo Muñoz
Clavaminols A-F, novel cytotoxic 2-amino-3-alkanols from the ascidian Clavelina phlegraea.
Bioorganic & medicinal chemistry 2007;15(8):2920-6.
2007: Francisco J Caballero; Carmen M Navarrete; Sandra Hess; Bernd L Fiebich; Giovanni Appendino; Antonio Macho; Eduardo Muñoz; Rocío Sancho
The acetaminophen-derived bioactive N-acylphenolamine AM404 inhibits NFAT by targeting nuclear regulatory events.
Biochemical pharmacology 2007;73(7):1013-23.
2006: Carmen M Navarrete; Rocío Sancho; Francisco J Caballero; Federica Pollastro; Bernd L Fiebich; Olov Sterner; Giovanni Appendino; Eduardo Muñoz
Basiliolides, a class of tetracyclic C19 dilactones from Thapsia garganica, release Ca(2+) from the endoplasmic reticulum and regulate the activity of the transcription factors nuclear factor of activated T cells, nuclear factor-kappaB, and activator protein 1 in T lymphocytes.
The Journal of pharmacology and experimental therapeutics 2006;319(1):422-30.
2006: Luis M Bedoya; Esther del Olmo; Rocío Sancho; Bianca Barboza; Manuela Beltrán; Ana E García-Cadenas; Sonsoles Sánchez-Palomino; José L López-Pérez; Eduardo Muñoz; Arturo San Feliciano; José Alcamí
Anti-HIV activity of stilbene-related heterocyclic compounds.
Bioorganic & medicinal chemistry letters 2006;16(15):4075-9.
2006: Giovanni Appendino; Lucia Maxia; Marcelo Bascope; Peter J Houghton; Gonzalo Sanchez-Duffhues; Eduardo Muñoz; Olov Sterner
A meroterpenoid NF-kappaB inhibitor and drimane sesquiterpenoids from Asafetida.
Journal of natural products 2006;69(7):1101-4.
2006: Nieves Márquez; Luciano De Petrocellis; Francisco J Caballero; Antonio Macho; Aniello Schiano Moriello; Alberto Minassi; Giovanni Appendino; Eduardo Muñoz; Vincenzo Di Marzo
Iodinated N-acylvanillamines: potential "multiple-target" anti-inflammatory agents acting via the inhibition of t-cell activation and antagonism at vanilloid TRPV1 channels.
Molecular pharmacology 2006;69(4):1373-82.
2006: Nadia J Jacobo-Herrera; Paul Bremner; Nieves Marquez; Mahabir P Gupta; Simon Gibbons; Eduardo Muñoz; Michael Heinrich
Physalins from Witheringia solanacea as modulators of the NF-kappaB cascade.
Journal of natural products 2006;69(3):328-31.
2006: Marcela Garita-Hernandez; Marco A Calzado; Francisco J Caballero; Antonio Macho; Eduardo Muñoz; Beat Meier; Axel Brattström; Bernd L Fiebich; Kurt Appel
The growth inhibitory activity of the Cimicifuga racemosa extract Ze 450 is mediated through estrogen and progesterone receptors-independent pathways.
Planta medica 2006;72(4):317-23.
2006: Nieves Márquez; Rocío Sancho; Antonio Macho; Alejandra Moure; Isabel Masip; Angel Messeguer; Eduardo Muñoz
Anti-Tat and anti-HIV activities of trimers of n-alkylglycines.
Biochemical pharmacology 2006;71(5):596-604.
2006: Enrique Aranda Aguilar; Juan de la Haba Rodríguez; Antonio Macho; Concha Lucena; Auxiliadora Gómez; Marco Calzado; Eduardo Muñoz
A study of the effect of salicylic acetic acid on a lymphocyte cell model of cellular activation and proliferation.
Cancer letters 2006;231(2):257-61.
2005: Luis M Bedoya; Manuela Beltrán; Rocío Sancho; Dionisio A Olmedo; Sonsoles Sánchez-Palomino; Esther del Olmo; José L López-Pérez; Eduardo Muñoz; Arturo San Feliciano; José Alcamí
4-Phenylcoumarins as HIV transcription inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(20):4447-50.
2005: Rocío Sancho; Laureano de la Vega; Antonio Macho; Giovanni Appendino; Vincenzo Di Marzo; Eduardo Muñoz
Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3990-9.
2005: Laureano de la Vega; Eduardo Muñoz; Marco A Calzado; Klaus Lieb; Eduardo Candelario-Jalil; Harald Gschaidmeir; Lothar Färber; Wolfgang Mueller; Thomas Stratz; Bernd L Fiebich
The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway.
Biochemical pharmacology 2005;70(3):369-80.
2005: Claudio Campagnuolo; Ernesto Fattorusso; Francesca Petrucci; Orazio Taglialatela-Scafati; Giovanni Appendino; Nieves Marquez; Eduardo Muñoz
A prenylbisabolane with NF-kappaB inhibiting properties from Cascarilla (Croton eluteria).
Bioorganic & medicinal chemistry 2005;13(13):4238-42.
2005: Nieves Márquez; Rocío Sancho; Luis M Bedoya; José Alcamí; José L López-Pérez; A San Feliciano; Bernd L Fiebich; Eduardo Muñoz
Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-kappaB pathway.
Antiviral research 2005;66(2-3):137-45.
2005: Anna Aiello; Ernesto Fattorusso; Paolo Luciano; Antonio Macho; Marialuisa Menna; Eduardo Muñoz
Antitumor effects of two novel naturally occurring terpene quinones isolated from the Mediterranean ascidian Aplidium conicum.
Journal of medicinal chemistry 2005;48(9):3410-6.
2005: Gabino Garrido; Magdalena Blanco-Molina; Rocío Sancho; Antonio Macho; René Delgado; Eduardo Muñoz
An aqueous stem bark extract of Mangifera indica (Vimang) inhibits T cell proliferation and TNF-induced activation of nuclear transcription factor NF-kappaB.
Phytotherapy research : PTR 2005;19(3):211-5.
2004: Nieves Márquez; Rocío Sancho; Mauro Ballero; Paul Bremner; Giovanni Appendino; Bernd L Fiebich; Michael Heinrich; Eduardo Muñoz
Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT.
Planta medica 2004;70(11):1016-21.
2004: Paul Bremner; S Tang; H Birkmayer; Bernd L Fiebich; Eduardo Muñoz; Nieves Marquez; D Rivera; Michael Heinrich
Phenylpropanoid NF-kappaB inhibitors from Bupleurum fruticosum.
Planta medica 2004;70(10):914-8.
2004: Rocío Sancho; Manuel Medarde; Sonsoles Sánchez-Palomino; Blanca Madrigal; José Alcamí; Eduardo Muñoz; Arturo San Feliciano
Anti-HIV activity of some synthetic lignanolides and intermediates.
Bioorganic & medicinal chemistry letters 2004;14(17):4483-6.
2004: Rocío Sancho; Nieves Márquez; Marta Gómez-Gonzalo; Marco A Calzado; Giorgio Bettoni; Mayte Coiras; José Alcamí; Manuel López-Cabrera; Giovanni Appendino; Eduardo Muñoz
Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway.
The Journal of biological chemistry 2004;279(36):37349-59.
2004: Antonio Macho; Magdalena Blanco-Molina; Paola Spagliardi; Giovanni Appendino; Paul Bremner; Michael Heinrich; Bernd L Fiebich; Eduardo Muñoz
Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line.
Biochemical pharmacology 2004;68(5):875-83.
2004: Marco A Calzado; Rocío Sancho; Eduardo Muñoz
Human immunodeficiency virus type 1 Tat increases the expression of cleavage and polyadenylation specificity factor 73-kilodalton subunit modulating cellular and viral expression.
Journal of virology 2004;78(13):6846-54.
2004: Giovanni Appendino; Federica Bianchi; Ammar Bader; Claudio Campagnuolo; Ernesto Fattorusso; Orazio Taglialatela-Scafati; Magdalena Blanco-Molina; Antonio Macho; Bernd L Fiebich; Paul Bremner; Michael Heinrich; Mauro Ballero; Eduardo Muñoz
Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin.
Journal of natural products 2004;67(4):532-6.
2004: Nieves Márquez; Rocío Sancho; Antonio Macho; Marco A Calzado; Bernd L Fiebich; Eduardo Muñoz
Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors.
The Journal of pharmacology and experimental therapeutics 2004;308(3):993-1001.
2004: Rocío Sancho; Antonio Macho; Laureano de la Vega; Marco A Calzado; Bernd L Fiebich; Giovanni Appendino; Eduardo Muñoz
Immunosuppressive activity of endovanilloids: N-arachidonoyl-dopamine inhibits activation of the NF-kappa B, NFAT, and activator protein 1 signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2341-51.
2003: Antonio Macho; Rocío Sancho; Alberto Minassi; Giovanni Appendino; Alfons Lawen; Eduardo Muñoz
Involvement of reactive oxygen species in capsaicinoid-induced apoptosis in transformed cells.
Free radical research 2003;37(6):611-9.
2003: Rocío Sancho; Marco A Calzado; Vincenzo Di Marzo; Giovanni Appendino; Eduardo Muñoz
Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway.
Molecular pharmacology 2003;63(2):429-38.
2003: Antonio Macho; Concepción Lucena; Rocío Sancho; Nives Daddario; Alberto Minassi; Eduardo Muñoz; Giovanni Appendino
Non-pungent capsaicinoids from sweet pepper synthesis and evaluation of the chemopreventive and anticancer potential.
European journal of nutrition 2003;42(1):2-9.
2002: Rocío Sancho; Concepción Lucena; Antonio Macho; Marco A Calzado; Magdalena Blanco-Molina; Alberto Minassi; Giovanni Appendino; Eduardo Muñoz
Immunosuppressive activity of capsaicinoids: capsiate derived from sweet peppers inhibits NF-kappaB activation and is a potent antiinflammatory compound in vivo.
European journal of immunology 2002;32(6):1753-63.
2002: Juan de la Haba Rodríguez; Antonio Macho; Marco A Calzado; MV Blázquez; M A Gómez; Eduardo Muñoz; E Aranda
Soluble dipeptidyl peptidase IV (CD-26) in serum of patients with colorectal carcinoma.
Neoplasma 2002;49(5):307-11.
2001: Magdalena Blanco-Molina; Gian Cesare Tron; Antonio Macho; Concepción Lucena; Marco A Calzado; Eduardo Muñoz; Giovanni Appendino
Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappaB independent pathway.
Chemistry & biology 2001;8(8):767-78.
2001: Maria Iorizzi; Virginia Lanzotti; Simona De Marino; Franco Zollo; Magdalena Blanco-Molina; Antonio Macho; Eduardo Muñoz
New glycosides from Capsicum annuum L. var. acuminatum. Isolation, structure determination, and biological activity.
Journal of agricultural and food chemistry 2001;49(4):2022-9.
2000: Antonio Macho; Concepción Lucena; Marco A Calzado; M Blanco; I Donnay; Giovanni Appendino; Eduardo Muñoz
Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism.
Chemistry & biology 2000;7(7):483-92.
2000: Marco A Calzado; Antonio Macho; Concepción Lucena; Eduardo Muñoz
Hydroxyurea inhibits the transactivation of the HIV-long-terminal repeat (LTR) promoter.
Clinical and experimental immunology 2000;120(2):317-23.
1999: Antonio Macho; Marco A Calzado; L Jiménez-Reina; Eva Ceballos; Javier León; Eduardo Muñoz
Susceptibility of HIV-1-TAT transfected cells to undergo apoptosis. Biochemical mechanisms.
Oncogene 1999;18(52):7543-51.
1999: MV Blázquez; Antonio Macho; C Ortiz; Concepción Lucena; Manuel López-Cabrera; F Sánchez-Madrid; Eduardo Muñoz
Extracellular HIV type 1 Tat protein induces CD69 expression through NF-kappaB activation: possible correlation with cell surface Tat-binding proteins.
AIDS research and human retroviruses 1999;15(13):1209-18.
1999: Antonio Macho; Marco A Calzado; Juan Muñoz-Blanco; Consuelo Gómez-Díaz; Consuelo Gajate; Faustino Mollinedo; Plácido Navas; Eduardo Muñoz
Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium.
Cell death and differentiation 1999;6(2):155-65.
1998: Antonio Macho; MV Blázquez; Plácido Navas; Eduardo Muñoz
Induction of apoptosis by vanilloid compounds does not require de novo gene transcription and activator protein 1 activity.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(3):277-86.
1997: Eduardo Muñoz; M V Blázquez; C Ortiz; C Gomez-Díaz; Plácido Navas
Role of ascorbate in the activation of NF-kappaB by tumour necrosis factor-alpha in T-cells.
The Biochemical journal 1997;325 ( Pt 1)():23-8.