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Andrew Munro

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TOP 3
Hazel M Girvan; Andrew W Munro
Heme sensor proteins.
Andrew W Munro; Adrian J Dunford; Hazel M Girvan; Amy E Mason; Kirsty J McLean
What makes a P450 tick?
Hannah F Collins; Jorge C Escalante-Semerena; Michael Gray; Helen K Leech; Kirsty J McLean; Andrew W Munro; Stephen E J Rigby; Martin J Warren; Rebekka Biedendieck; Andrew D Lawrence
Bacillus megaterium has both a functional BluB protein required for DMB synthesis and a related flavoprotein that forms a stable radical species.

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All Publications

2013: Hazel M Girvan; Andrew W Munro
Heme sensor proteins.
The Journal of biological chemistry 2013;288(19):13194-203.
2013: Andrew W Munro; Adrian J Dunford; Hazel M Girvan; Amy E Mason; Kirsty J McLean
What makes a P450 tick?
Trends in biochemical sciences 2013;38(3):140-50.
2013: Hannah F Collins; Jorge C Escalante-Semerena; Michael Gray; Helen K Leech; Kirsty J McLean; Andrew W Munro; Stephen E J Rigby; Martin J Warren; Rebekka Biedendieck; Andrew D Lawrence
Bacillus megaterium has both a functional BluB protein required for DMB synthesis and a related flavoprotein that forms a stable radical species.
PloS one 2013;8(2):e55708.
2012: Kirsty J McLean; Marcus Hans; Andrew W Munro
Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes.
Biochemical Society transactions 2012;40(3):587-93.
2012: Soi H Bui; Myles R Cheesman; Colin W Levy; David Leys; Kirsty J McLean; Justin M Bradley; Stephen E J Rigby; Andrew W Munro
Unusual spectroscopic and ligand binding properties of the cytochrome P450-flavodoxin fusion enzyme XplA.
The Journal of biological chemistry 2012;287(23):19699-714.
2012: Andrew W Munro; David Leys
Special issue: Cytochrome P450 structure and function: introduction.
The FEBS journal 2012;279(9):1515.
2012: M Gordon Joyce; Andrew W Munro; Rajasekhar Neeli; Olivier Roitel; George J Baker; Robin A Curtis; Adrian J Dunford; Idorenyin S Ekanem; Hazel M Girvan; David Leys
The crystal structure of the FAD/NADPH-binding domain of flavocytochrome P450 BM3.
The FEBS journal 2012;279(9):1694-706.
2012: Ashley J Warman; Martin J Warren; Andrew W Munro; Stephen E J Rigby; Jacob W Robinson; Myles R Cheesman; Andrew D Lawrence; Dominika Luciakova; Ker R Marshall; Kirsty J McLean
Characterization of Cupriavidus metallidurans CYP116B1--a thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein.
The FEBS journal 2012;279(9):1675-93.
2011: Timothy N Waltham; Hazel M Girvan; Christopher F Butler; Stuart R Rigby; Adrian J Dunford; Robert A Holt; Andrew W Munro
Analysis of the oxidation of short chain alkynes by flavocytochrome P450 BM3.
Metallomics : integrated biometal science 2011;3(4):369-78.
2011: Caroline G Bowsher; L M Eyres; J O Gummadova; Parvinder Hothi; Kirsty J McLean; Andrew W Munro; Nigel S Scrutton; G T Hanke; Y Sakakibara; T Hase
Identification of N-terminal regions of wheat leaf ferredoxin NADP+ oxidoreductase important for interactions with ferredoxin.
Biochemistry 2011;50(11):1778-87.
2011: Hazel M Girvan; Adrian J Dunford; Rajasekhar Neeli; Idorenyin S Ekanem; Timothy N Waltham; M Gordon Joyce; David Leys; Robin A Curtis; Paul Williams; Karl Fisher; Michael W Voice; Andrew W Munro
Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer.
Archives of biochemistry and biophysics 2011;507(1):75-85.
2011: Max D Driscoll; Kirsty J McLean; Myles R Cheesman; Thomas A Jowitt; Marjorie Howard; Paul Carroll; Tanya Parish; Andrew W Munro
Expression and characterization of Mycobacterium tuberculosis CYP144: common themes and lessons learned in the M. tuberculosis P450 enzyme family.
Biochimica et biophysica acta 2011;1814(1):76-87.
2010: Max D Driscoll; Kirsty J McLean; Colin Levy; Natalia Mast; Irina A Pikuleva; Pierre Lafite; Stephen E J Rigby; David Leys; Andrew W Munro
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.
The Journal of biological chemistry 2010;285(49):38270-82.
2010: Kirsty J McLean; James Belcher; Max D Driscoll; Christine C Fernandez; Duyet Le Van; Soi Bui; Marina Golovanova; Andrew W Munro
The Mycobacterium tuberculosis cytochromes P450: physiology, biochemistry & molecular intervention.
Future medicinal chemistry 2010;2(8):1339-53.
2010: Rachel V Dunn; Andrew W Munro; Nicholas J Turner; Stephen E J Rigby; Nigel S Scrutton
Tyrosyl radical formation and propagation in flavin dependent monoamine oxidases.
Chembiochem : a European journal of chemical biology 2010;11(9):1228-31.
2010: Hazel M Girvan; Colin W Levy; Paul Williams; Karl Fisher; Myles R Cheesman; Stephen E J Rigby; David Leys; Andrew W Munro
Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3.
The Biochemical journal 2010;427(3):455-66.
2010: Joshua B Parsons; Andrew D Lawrence; Kirsty J McLean; Andrew W Munro; Stephen E J Rigby; Martin J Warren
Characterisation of PduS, the pdu metabolosome corrin reductase, and evidence of substructural organisation within the bacterial microcompartment.
PloS one 2010;5(11):e14009.
2009: Kirsty J McLean; Pierre Lafite; Colin Levy; Myles R Cheesman; Natalia Mast; Irina A Pikuleva; David Leys; Andrew W Munro
The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
The Journal of biological chemistry 2009;284(51):35524-33.
2009: Adrian J Dunford; Hazel M Girvan; Nigel S Scrutton; Andrew W Munro
Probing the molecular determinants of coenzyme selectivity in the P450 BM3 FAD/NADPH domain.
Biochimica et biophysica acta 2009;1794(8):1181-9.
2009: Andrew W Munro; Nigel S Scrutton
Enzyme mechanisms: fast reaction and computational approaches.
Biochemical Society transactions 2009;37(Pt 2):333-5.
2009: Derren J Heyes; Anne-Marie Quinn; Paul M Cullis; Michael Lee; Andrew W Munro; Nigel S Scrutton
Internal electron transfer in multi-site redox enzymes is accessed by laser excitation of thiouredopyrene-3,6,8-trisulfonate (TUPS).
Chemical communications (Cambridge, England) 2009;(9):1124-6.
2009: Susanne Schroeder; Andrew D Lawrence; Rebekka Biedendieck; Ruth-Sarah Rose; Evelyne C Deery; Ross M Graham; Kirsty J McLean; Andrew W Munro; Stephen E J Rigby; Martin J Warren
Demonstration that CobG, the monooxygenase associated with the ring contraction process of the aerobic cobalamin (vitamin B12) biosynthetic pathway, contains an Fe-S center and a mononuclear non-heme iron center.
The Journal of biological chemistry 2009;284(8):4796-805.
2009: Muna Sabri; Adrian J Dunford; Kirsty J McLean; Rajasekhar Neeli; Nigel S Scrutton; David Leys; Andrew W Munro
Characterization of coenzyme binding and selectivity determinants in Mycobacterium tuberculosis flavoprotein reductase A: analysis of Arg(199) and Arg(200) mutants at the NADP(H) 2'-phosphate binding site.
The Biochemical journal 2009;417(1):103-12.
2009: Hazel M Girvan; Helen S Toogood; Rachael E Littleford; Harriet E Seward; W Ewen Smith; Idorenyin S Ekanem; David Leys; Myles R Cheesman; Andrew W Munro
Novel haem co-ordination variants of flavocytochrome P450BM3.
The Biochemical journal 2009;417(1):65-76.
2008: Philip R Balding; Cristina S Porro; Kirsty J McLean; Michael J Sutcliffe; Jean-Didier Marechal; Andrew W Munro; Sam P de Visser
How do azoles inhibit cytochrome P450 enzymes? A density functional study.
The journal of physical chemistry. A 2008;112(50):12911-8.
2008: Kirsty J McLean; Paul Carroll; D Geraint Lewis; Adrian J Dunford; Harriet E Seward; Rajasekhar Neeli; Myles R Cheesman; Laurent Marsollier; Philip Douglas; W Ewen Smith; Ida Rosenkrands; Stewart T Cole; David Leys; Tanya Parish; Andrew W Munro
Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.
The Journal of biological chemistry 2008;283(48):33406-16.
2008: Sibylle Brenner; sam hay; Andrew W Munro; Nigel S Scrutton
Inter-flavin electron transfer in cytochrome P450 reductase - effects of solvent and pH identify hidden complexity in mechanism.
The FEBS journal 2008;275(18):4540-57.
2008: Rachel V Dunn; Ker R Marshall; Andrew W Munro; Nigel S Scrutton
The pH dependence of kinetic isotope effects in monoamine oxidase A indicates stabilization of the neutral amine in the enzyme-substrate complex.
The FEBS journal 2008;275(15):3850-8.
2008: Joshua B Parsons; SELLATHAMBY DINESH; Evelyne C Deery; Helen K Leech; Amanda A Brindley; Dana Heldt; Steffanie Frank; C Mark Smales; Heinrich Lünsdorf; Alain Rambach; Mhairi H Gass; Andrew Bleloch; Kirsty J McClean; Andrew W Munro; Stephen E J Rigby; Martin J Warren; Michael B Prentice
Biochemical and structural insights into bacterial organelle form and biogenesis.
The Journal of biological chemistry 2008;283(21):14366-75.
2008: Rajasekhar Neeli; Muna Sabri; Kirsty J McLean; Adrian J Dunford; Nigel S Scrutton; David Leys; Andrew W Munro
Trp(359) regulates flavin thermodynamics and coenzyme selectivity in Mycobacterium tuberculosis FprA.
The Biochemical journal 2008;411(3):563-70.
2008: Kirsty J McLean; Andrew W Munro
Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis.
Drug metabolism reviews 2008;40(3):427-46.
2007: Kirsty J McLean; Hazel M Girvan; Andrew W Munro
Cytochrome P450/redox partner fusion enzymes: biotechnological and toxicological prospects.
Expert opinion on drug metabolism & toxicology 2007;3(6):847-63.
2007: Min Gong; sam hay; Ker R Marshall; Andrew W Munro; Nigel S Scrutton
DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis.
The Journal of biological chemistry 2007;282(41):30331-40.
2007: Adrian J Dunford; Kirsty J McLean; Muna Sabri; Harriet E Seward; Derren J Heyes; Nigel S Scrutton; Andrew W Munro
Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.
The Journal of biological chemistry 2007;282(34):24816-24.
2007: Kirsty J McLean; Adrian J Dunford; Rajasekhar Neeli; Max D Driscoll; Andrew W Munro
Structure, function and drug targeting in Mycobacterium tuberculosis cytochrome P450 systems.
Archives of biochemistry and biophysics 2007;464(2):228-40.
2007: Sibylle Brenner; sam hay; Hazel M Girvan; Andrew W Munro; Nigel S Scrutton
Conformational dynamics of the cytochrome P450 BM3/N-palmitoylglycine complex: the proposed "proximal-distal" transition probed by temperature-jump spectroscopy.
The journal of physical chemistry. B 2007;111(27):7879-86.
2007: Igor Efimov; Nektaria D Papadopoulou; Kirsty J McLean; Sandip K Badyal; Isabel K Macdonald; Andrew W Munro; Peter C E Moody; Emma Lloyd Raven
The redox properties of ascorbate peroxidase.
Biochemistry 2007;46(27):8017-23.
2007: Andrew W Munro; Hazel M Girvan; Kirsty J McLean
Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily.
Natural product reports 2007;24(3):585-609.
2007: Hazel M Girvan; Derren J Heyes; Nigel S Scrutton; Andrew W Munro
Laser photoexcitation of NAD(P)H induces reduction of P450 BM3 heme domain on the microsecond time scale.
Journal of the American Chemical Society 2007;129(20):6647-53.
2007: Adrian J Dunford; Stephen E J Rigby; sam hay; Andrew W Munro; Nigel S Scrutton
Conformational and thermodynamic control of electron transfer in neuronal nitric oxide synthase.
Biochemistry 2007;46(17):5018-29.
2007: Andrew W Munro; Hazel M Girvan; Kirsty J McLean
Cytochrome P450--redox partner fusion enzymes.
Biochimica et biophysica acta 2007;1770(3):345-59.
2007: Hazel M Girvan; Harriet E Seward; Helen S Toogood; Myles R Cheesman; David Leys; Andrew W Munro
Structural and spectroscopic characterization of P450 BM3 mutants with unprecedented P450 heme iron ligand sets. New heme ligation states influence conformational equilibria in P450 BM3.
The Journal of biological chemistry 2007;282(1):564-72.
2007: Michael A Noble; Hazel M Girvan; Susan J Smith; W Ewen Smith; Marat B Murataliev; Victor M Guzov; René Feyereisen; Andrew W Munro
Analysis of the interactions of cytochrome b5 with flavocytochrome P450 BM3 and its domains.
Drug metabolism reviews 2007;39(2-3):599-617.
2006: Harriet E Seward; Anna Roujeinikova; Kirsty J McLean; Andrew W Munro; David Leys
Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode.
The Journal of biological chemistry 2006;281(51):39437-43.
2006: Kirsty J McLean; Adrian J Dunford; Muna Sabri; Rajasekhar Neeli; Hazel M Girvan; Philip R Balding; David Leys; Harriet E Seward; Ker R Marshall; Andrew W Munro
CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen.
Biochemical Society transactions 2006;34(Pt 6):1178-82.
2006: Hazel M Girvan; T N Waltham; Rajasekhar Neeli; H F Collins; Kirsty J McLean; Nigel S Scrutton; David Leys; Andrew W Munro
Flavocytochrome P450 BM3 and the origin of CYP102 fusion species.
Biochemical Society transactions 2006;34(Pt 6):1173-7.
2006: Kirsty J McLean; Ashley J Warman; Harriet E Seward; Ker R Marshall; Hazel M Girvan; Myles R Cheesman; Michael R Waterman; Andrew W Munro
Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.
Biochemistry 2006;45(27):8427-43.
2006: Jonathan P Combe; Jaswir Basran; Parvinder Hothi; David Leys; Stephen E J Rigby; Andrew W Munro; Nigel S Scrutton
Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis.
The Journal of biological chemistry 2006;281(26):17977-88.
2006: Kirsty J McLean; Daniel Clift; D Geraint Lewis; Muna Sabri; Philip R Balding; Michael J Sutcliffe; David Leys; Andrew W Munro
The preponderance of P450s in the Mycobacterium tuberculosis genome.
Trends in microbiology 2006;14(5):220-8.
2005: Harriet E Seward; Hazel M Girvan; Andrew W Munro
Cytochrome P450s: creating novel ligand sets.
Dalton transactions (Cambridge, England : 2003) 2005;(21):3419-26.
2005: Nektaria D Papadopoulou; Martin Mewies; Kirsty J McLean; Harriet E Seward; Dimitri A Svistunenko; Andrew W Munro; Emma Lloyd Raven
Redox and spectroscopic properties of human indoleamine 2,3-dioxygenase and a His303Ala variant: implications for catalysis.
Biochemistry 2005;44(43):14318-28.
2005: Rajasekhar Neeli; Hazel M Girvan; Andrew Lawrence; Martin J Warren; David Leys; Nigel S Scrutton; Andrew W Munro
The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase.
FEBS letters 2005;579(25):5582-8.
2005: Ker R Marshall; Min Gong; Leigh Wodke; John H Lamb; Donald J L Jones; Peter B Farmer; Nigel S Scrutton; Andrew W Munro
The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity.
The Journal of biological chemistry 2005;280(35):30735-40.
2005: Huma Khan; Terez Barna; Neil C Bruce; Andrew W Munro; David Leys; Nigel S Scrutton
Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase. Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181, His184.
The FEBS journal 2005;272(18):4660-71.
2005: Kirsty J McLean; Muna Sabri; Ker R Marshall; Rachel J Lawson; D G Lewis; D Clift; Philip R Balding; Adrian J Dunford; Ashley J Warman; J P McVey; A-M Quinn; Michael J Sutcliffe; Nigel S Scrutton; Andrew W Munro
Biodiversity of cytochrome P450 redox systems.
Biochemical Society transactions 2005;33(Pt 4):796-801.
2005: Stephen E J Rigby; Jaswir Basran; Jonathan P Combe; Al-Walid A Mohsen; Helen S Toogood; Adam van Thiel; Michael J Sutcliffe; David Leys; Andrew W Munro; Nigel S Scrutton
Flavoenzyme catalysed oxidation of amines: roles for flavin and protein-based radicals.
Biochemical Society transactions 2005;33(Pt 4):754-7.
2005: Ashley J Warman; Olivier Roitel; Rajasekhar Neeli; Hazel M Girvan; Harriet E Seward; S A Murray; Kirsty J McLean; M Gordon Joyce; Helen S Toogood; R A Holt; David Leys; Nigel S Scrutton; Andrew W Munro
Flavocytochrome P450 BM3: an update on structure and mechanism of a biotechnologically important enzyme.
Biochemical Society transactions 2005;33(Pt 4):747-53.
2005: Hanan Messiha; Neil C Bruce; Benedict M Sattelle; Michael J Sutcliffe; Andrew W Munro; Nigel S Scrutton
Role of active site residues and solvent in proton transfer and the modulation of flavin reduction potential in bacterial morphinone reductase.
The Journal of biological chemistry 2005;280(29):27103-10.
2005: Rajasekhar Neeli; Olivier Roitel; Nigel S Scrutton; Andrew W Munro
Switching pyridine nucleotide specificity in P450 BM3: mechanistic analysis of the W1046H and W1046A enzymes.
The Journal of biological chemistry 2005;280(18):17634-44.
2005: Hanan Messiha; Andrew W Munro; Neil C Bruce; Igor Barsukov; Nigel S Scrutton
Reaction of morphinone reductase with 2-cyclohexen-1-one and 1-nitrocyclohexene: proton donation, ligand binding, and the role of residues Histidine 186 and Asparagine 189.
The Journal of biological chemistry 2005;280(11):10695-709.
2005: Stephen E J Rigby; Robert M G Hynson; Rona R Ramsay; Andrew W Munro; Nigel S Scrutton
A stable tyrosyl radical in monoamine oxidase A.
The Journal of biological chemistry 2005;280(6):4627-31.
2005: Evelyne Raux-Deery; Helen K Leech; Kerry-Ann Nakrieko; Kirsty J McLean; Andrew W Munro; Peter Heathcote; Stephen E J Rigby; Alison G Smith; Martin J Warren
Identification and characterization of the terminal enzyme of siroheme biosynthesis from Arabidopsis thaliana: a plastid-located sirohydrochlorin ferrochelatase containing a 2FE-2S center.
The Journal of biological chemistry 2005;280(6):4713-21.
2005: Helen M McGoldrick; Charles A Roessner; Evelyne Raux; Andrew D Lawrence; Kirsty J McLean; Andrew W Munro; Stefano Santabarbara; Stephen E J Rigby; Peter Heathcote; A Ian Scott; Martin J Warren
Identification and characterization of a novel vitamin B12 (cobalamin) biosynthetic enzyme (CobZ) from Rhodobacter capsulatus, containing flavin, heme, and Fe-S cofactors.
The Journal of biological chemistry 2005;280(2):1086-94.
2004: Luca Quaroni; Harriet E Seward; Kirsty J McLean; Hazel M Girvan; Tobias W B Ost; Michael A Noble; Sharon M Kelly; Nicholas C Price; Myles R Cheesman; W Ewen Smith; Andrew W Munro
Interaction of nitric oxide with cytochrome P450 BM3.
Biochemistry 2004;43(51):16416-31.
2004: Rachel J Lawson; David Leys; Michael J Sutcliffe; Carol A Kemp; Myles R Cheesman; Susan J Smith; John Clarkson; W Ewen Smith; Ihtshamul Haq; John B Perkins; Andrew W Munro
Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis.
Biochemistry 2004;43(39):12410-26.
2004: Rachel J Lawson; Claes von Wachenfeldt; Ihtshamul Haq; John Perkins; Andrew W Munro
Expression and characterization of the two flavodoxin proteins of Bacillus subtilis, YkuN and YkuP: biophysical properties and interactions with cytochrome P450 BioI.
Biochemistry 2004;43(39):12390-409.
2004: Huma Khan; Terez Barna; Richard J Harris; Neil C Bruce; Igor Barsukov; Andrew W Munro; Peter C E Moody; Nigel S Scrutton
Atomic resolution structures and solution behavior of enzyme-substrate complexes of Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase. Multiple conformational states and implications for the mechanism of nitroaromatic explosive degradation.
The Journal of biological chemistry 2004;279(29):30563-72.
2004: Adrian J Dunford; Ker R Marshall; Andrew W Munro; Nigel S Scrutton
Thermodynamic and kinetic analysis of the isolated FAD domain of rat neuronal nitric oxide synthase altered in the region of the FAD shielding residue Phe1395.
European journal of biochemistry / FEBS 2004;271(12):2548-60.
2004: Al-Walid A Mohsen; Stephen E J Rigby; Kaj Frank Jensen; Andrew W Munro; Nigel S Scrutton
Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy.
Biochemistry 2004;43(21):6498-510.
2004: Hazel M Girvan; Ker R Marshall; Rachel J Lawson; David Leys; M Gordon Joyce; John Clarkson; W Ewen Smith; Myles R Cheesman; Andrew W Munro
Flavocytochrome P450 BM3 mutant A264E undergoes substrate-dependent formation of a novel heme iron ligand set.
The Journal of biological chemistry 2004;279(22):23274-86.
2004: M Gordon Joyce; Hazel M Girvan; Andrew W Munro; David Leys
A single mutation in cytochrome P450 BM3 induces the conformational rearrangement seen upon substrate binding in the wild-type enzyme.
The Journal of biological chemistry 2004;279(22):23287-93.
2004: Mattias Gustafsson; Olivier Roitel; Ker R Marshall; Michael A Noble; Stephen K Chapman; Antonio Pessegueiro; Armand J Fulco; Myles R Cheesman; Claes von Wachenfeldt; Andrew W Munro
Expression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megaterium.
Biochemistry 2004;43(18):5474-87.
2004: David Leys; Jaswir Basran; François Talfournier; Kamaldeep K Chohan; Andrew W Munro; Michael J Sutcliffe; Nigel S Scrutton
Flavin radicals, conformational sampling and robust design principles in interprotein electron transfer: the trimethylamine dehydrogenase-electron-transferring flavoprotein complex.
Biochemical Society symposium 2004;(71):1-14.
2003: S J Smith; Andrew W Munro; W Ewen Smith
Resonance Raman scattering of cytochrome P450 BM3 and effect of imidazole inhibitors.
Biopolymers 2003;70(4):620-7.
2003: Stéphane Marchal; Hazel M Girvan; Antonius C F Gorren; Bernd Mayer; Andrew W Munro; Claude Balny; Reinhard Lange
Formation of transient oxygen complexes of cytochrome p450 BM3 and nitric oxide synthase under high pressure.
Biophysical journal 2003;85(5):3303-9.
2003: Helen K Leech; Evelyne Raux; Kirsty J McLean; Andrew W Munro; Nigel J Robinson; Gilles P M Borrelly; Marco Malten; Dieter Jahn; Stephen E J Rigby; Peter Heathcote; Martin J Warren
Characterization of the cobaltochelatase CbiXL: evidence for a 4Fe-4S center housed within an MXCXXC motif.
The Journal of biological chemistry 2003;278(43):41900-7.
2003: Olivier Roitel; Nigel S Scrutton; Andrew W Munro
Electron transfer in flavocytochrome P450 BM3: kinetics of flavin reduction and oxidation, the role of cysteine 999, and relationships with mammalian cytochrome P450 reductase.
Biochemistry 2003;42(36):10809-21.
2003: Aldo Gutierrez; Andrew W Munro; Alex Grunau; C Roland Wolf; Nigel S Scrutton; Gordon Roberts
Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues.
European journal of biochemistry / FEBS 2003;270(12):2612-21.
2003: Andrew W Munro; Kirsty J McLean; Ker R Marshall; Ashley J Warman; G Lewis; Olivier Roitel; Michael J Sutcliffe; Carol A Kemp; S Modi; Nigel S Scrutton; David Leys
Cytochromes P450: novel drug targets in the war against multidrug-resistant Mycobacterium tuberculosis.
Biochemical Society transactions 2003;31(Pt 3):625-30.
2003: Aldo Gutierrez; Alex Grunau; Mark Paine; Andrew W Munro; C Roland Wolf; Gordon Roberts; Nigel S Scrutton
Electron transfer in human cytochrome P450 reductase.
Biochemical Society transactions 2003;31(Pt 3):497-501.
2003: Kirsty J McLean; Nigel S Scrutton; Andrew W Munro
Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA.
The Biochemical journal 2003;372(Pt 2):317-27.
2003: Kirsten R Wolthers; Jaswir Basran; Andrew W Munro; Nigel S Scrutton
Molecular dissection of human methionine synthase reductase: determination of the flavin redox potentials in full-length enzyme and isolated flavin-binding domains.
Biochemistry 2003;42(13):3911-20.
2003: Robert D Finn; Jaswir Basran; Olivier Roitel; C Roland Wolf; Andrew W Munro; Mark Paine; Nigel S Scrutton
Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1.
European journal of biochemistry / FEBS 2003;270(6):1164-75.
2003: David Leys; Christopher G Mowat; Kirsty J McLean; Alison Richmond; Stephen K Chapman; Malcolm D Walkinshaw; Andrew W Munro
Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450.
The Journal of biological chemistry 2003;278(7):5141-7.
2003: Amanda J Green; Andrew W Munro; Myles R Cheesman; Graeme A Reid; Claes von Wachenfeldt; Stephen K Chapman
Expression, purification and characterisation of a Bacillus subtilis ferredoxin: a potential electron transfer donor to cytochrome P450 BioI.
Journal of inorganic biochemistry 2003;93(1-2):92-9.
2002: Kirsty J McLean; Ker R Marshall; Alison Richmond; Iain S Hunter; Kay Fowler; Tobias Kieser; Sudagar S Gurcha; Gurdyal S Besra; Andrew W Munro
Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.
Microbiology (Reading, England) 2002;148(Pt 10):2937-49.
2002: Kirsty J McLean; Myles R Cheesman; Stuart L Rivers; Alison Richmond; David Leys; Stephen K Chapman; Graeme A Reid; Nicholas C Price; Sharon M Kelly; John Clarkson; W Ewen Smith; Andrew W Munro
Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis.
Journal of inorganic biochemistry 2002;91(4):527-41.
2002: Shigeyoshu Fuziwara; Ikuko Sagami; Elena A Rozhkova; Daniel Craig; Michael A Noble; Andrew W Munro; Stephen K Chapman; Toru Shimizu
Catalytically functional flavocytochrome chimeras of P450 BM3 and nitric oxide synthase.
Journal of inorganic biochemistry 2002;91(4):515-26.
2002: Huma Khan; Richard J Harris; Terez Barna; Daniel H Craig; Neil C Bruce; Andrew W Munro; Peter C E Moody; Nigel S Scrutton
Kinetic and structural basis of reactivity of pentaerythritol tetranitrate reductase with NADPH, 2-cyclohexenone, nitroesters, and nitroaromatic explosives.
The Journal of biological chemistry 2002;277(24):21906-12.
2002: Andrew W Munro; David G Leys; Kirsty J McLean; Ker R Marshall; Tobias W B Ost; Simon Daff; Caroline S Miles; Stephen K Chapman; Dominikus Lysek; Christopher C Moser; Christopher C Page; P Leslie Dutton
P450 BM3: the very model of a modern flavocytochrome.
Trends in biochemical sciences 2002;27(5):250-7.
2002: Christopher G Mowat; David Leys; Kirsty J McLean; Stuart L Rivers; Alison Richmond; Andrew W Munro; Miguel Ortiz Lombardia; Pedro Alzari; Graeme A Reid; Stephen K Chapman; Malcolm D Walkinshaw
Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 4):704-5.
2001: Tobias W B Ost; Andrew W Munro; Christopher G Mowat; P R Taylor; A Pesseguiero; A J Fulco; A K Cho; M A Cheesman; Malcolm D Walkinshaw; Stephen K Chapman
Structural and spectroscopic analysis of the F393H mutant of flavocytochrome P450 BM3.
Biochemistry 2001;40(45):13430-8.
2001: Tobias W B Ost; Caroline S Miles; Andrew W Munro; J Murdoch; Graeme A Reid; Stephen K Chapman
Phenylalanine 393 exerts thermodynamic control over the heme of flavocytochrome P450 BM3.
Biochemistry 2001;40(45):13421-9.
2001: Daniel H Craig; Terez Barna; Peter C E Moody; Neil C Bruce; Stephen K Chapman; Andrew W Munro; Nigel S Scrutton
Effects of environment on flavin reactivity in morphinone reductase: analysis of enzymes displaying differential charge near the N-1 atom and C-2 carbonyl region of the active-site flavin.
The Biochemical journal 2001;359(Pt 2):315-23.
2001: François Talfournier; Andrew W Munro; Jaswir Basran; Michael J Sutcliffe; Simon Daff; Stephen K Chapman; Nigel S Scrutton
alpha Arg-237 in Methylophilus methylotrophus (sp. W3A1) electron-transferring flavoprotein affords approximately 200-millivolt stabilization of the FAD anionic semiquinone and a kinetic block on full reduction to the dihydroquinone.
The Journal of biological chemistry 2001;276(23):20190-6.
2001: A J Green; Stuart L Rivers; M Cheeseman; Graeme A Reid; Luca Quaroni; ID Macdonald; Stephen K Chapman; Andrew W Munro
Expression, purification and characterization of cytochrome P450 Biol: a novel P450 involved in biotin synthesis in Bacillus subtilis.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(5-6):523-33.
2001: Simon Daff; Michael A Noble; Daniel H Craig; Stuart L Rivers; Stephen K Chapman; Andrew W Munro; S Fujiwara; Elena A Rozhkova; Ikuko Sagami; Toru Shimizu
Control of electron transfer in neuronal NO synthase.
Biochemical Society transactions 2001;29(Pt 2):147-52.
2001: Andrew W Munro; Michael A Noble; L Robledo; Simon Daff; Stephen K Chapman
Determination of the redox properties of human NADPH-cytochrome P450 reductase.
Biochemistry 2001;40(7):1956-63.
2000: Caroline S Miles; Tobias W B Ost; Michael A Noble; Andrew W Munro; Stephen K Chapman
Protein engineering of cytochromes P-450.
Biochimica et biophysica acta 2000;1543(2):383-407.
2000: Tobias W B Ost; Caroline S Miles; J Murdoch; Y Cheung; Graeme A Reid; Stephen K Chapman; Andrew W Munro
Rational re-design of the substrate binding site of flavocytochrome P450 BM3.
FEBS letters 2000;486(2):173-7.
2000: C Leadbeater; Lisa McIver; Dominic J Campopiano; Scott P Webster; Robert L Baxter; Sharon M Kelly; Nicholas C Price; Dominikus Lysek; Michael A Noble; Stephen K Chapman; Andrew W Munro
Probing the NADPH-binding site of Escherichia coli flavodoxin oxidoreductase.
The Biochemical journal 2000;352 Pt 2():257-66.
2000: Christopher G Mowat; Caroline S Miles; Andrew W Munro; Myles R Cheesman; Luca Quaroni; Graeme A Reid; Stephen K Chapman
Changing the heme ligation in flavocytochrome b2: substitution of histidine-66 by cysteine.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(5):584-92.
2000: Andrew W Munro; P Taylor; M D Walkinshaw
Structures of redox enzymes.
Current opinion in biotechnology 2000;11(4):369-76.
2000: Andrew W Munro; Michael A Noble; Tobias W B Ost; A J Green; Kirsty J McLean; L Robledo; Caroline S Miles; J Murdoch; Stephen K Chapman
Flavocytochrome P450 BM3 substrate selectivity and electron transfer in a model cytochrome P450.
Sub-cellular biochemistry 2000;35():297-315.
1999: Michael A Noble; Andrew W Munro; Stuart L Rivers; L Robledo; Simon Daff; Lesley J Yellowlees; Toru Shimizu; Ikuko Sagami; J G Guillemette; Stephen K Chapman
Potentiometric analysis of the flavin cofactors of neuronal nitric oxide synthase.
Biochemistry 1999;38(50):16413-8.
1999: Michael A Noble; Caroline S Miles; Stephen K Chapman; Dominikus Lysek; A C MacKay; Graeme A Reid; R P Hanzlik; Andrew W Munro
Roles of key active-site residues in flavocytochrome P450 BM3.
The Biochemical journal 1999;339 ( Pt 2)():371-9.
1999: Andrew W Munro; Michael A Noble; Caroline S Miles; Simon Daff; A J Green; Luca Quaroni; Stuart L Rivers; Tobias W B Ost; Graeme A Reid; Stephen K Chapman
Flavocytochrome P-450 BM3: a paradigm for the analysis of electron transfer and its control in the P-450s.
Biochemical Society transactions 1999;27(2):190-6.
1999: Stephen K Chapman; F K S Welsh; RK Moysey; Christopher G Mowat; Mary K Doherty; KL Turner; Andrew W Munro; Graeme A Reid
Flavocytochromes: transceivers and relays in biological electron transfer.
Biochemical Society transactions 1999;27(2):185-9.
1999: Andrew W Munro; Sharon M Kelly; N C Price
Circular dichroism studies of flavoproteins.
Methods in molecular biology (Clifton, N.J.) 1999;131():111-23.
1999: Andrew W Munro; Michael A Noble
Fluorescence analysis of flavoproteins.
Methods in molecular biology (Clifton, N.J.) 1999;131():25-48.
1998: Michael A Noble; Luca Quaroni; George Chumanov; KL Turner; Stephen K Chapman; R P Hanzlik; Andrew W Munro
Imidazolyl carboxylic acids as mechanistic probes of flavocytochrome P-450 BM3.
Biochemistry 1998;37(45):15799-807.
1998: Lisa McIver; C Leadbeater; Dominic J Campopiano; Robert L Baxter; Simon Daff; Stephen K Chapman; Andrew W Munro
Characterisation of flavodoxin NADP+ oxidoreductase and flavodoxin; key components of electron transfer in Escherichia coli.
European journal of biochemistry / FEBS 1998;257(3):577-85.
1998: Michael A Noble; KL Turner; Stephen K Chapman; Andrew W Munro
Mechanistic probes of flavocytochrome P-450 BM3.
Biochemical Society transactions 1998;26(3):S213.
1998: Andrew W Munro; Michael A Noble; KL Turner; Stephen K Chapman
The interaction of eukaryotic cytochrome b5 with flavocytochrome P-450 BM3 from Bacillus megaterium.
Biochemical Society transactions 1998;26(3):S212.
1998: ID Macdonald; Andrew W Munro; W Ewen Smith
Fatty acid-induced alteration of the porphyrin macrocycle of cytochrome P450 BM3.
Biophysical journal 1998;74(6):3241-9.
1997: Simon Daff; Stephen K Chapman; KL Turner; R A Holt; S Govindaraj; T L Poulos; Andrew W Munro
Redox control of the catalytic cycle of flavocytochrome P-450 BM3.
Biochemistry 1997;36(45):13816-23.
1997: Andrew W Munro; Simon Daff; KL Turner; Stephen K Chapman
Probing inter-domain electron transfer in a model flavocytochrome P-450.
Biochemical Society transactions 1997;25(4):S629.
1997: Andrew W Munro; Simon Daff; KL Turner; Stephen K Chapman
Redox characterisation of flavocytochrome P-450 BM3 from Bacillus megaterium.
Biochemical Society transactions 1997;25(4):S628.
1996: Andrew W Munro; J Gordon Lindsay; John R Coggins; Sharon M Kelly; Nicholas C Price
Analysis of the structural stability of the multidomain enzyme flavocytochrome P-450 BM3.
Biochimica et biophysica acta 1996;1296(2):127-37.
1996: Andrew W Munro; Simon Daff; John R Coggins; J Gordon Lindsay; Stephen K Chapman
Probing electron transfer in flavocytochrome P-450 BM3 and its component domains.
European journal of biochemistry / FEBS 1996;239(2):403-9.
1996: Andrew W Munro; J Gordon Lindsay
Bacterial cytochromes P-450.
Molecular microbiology 1996;20(6):1115-25.
1996: Andrew W Munro; John R Coggins; J Gordon Lindsay; S Kelly; Nicholas C Price
Deflavination of cytochrome P450 BM3 by treatment with guanidinium chloride.
Biochemical Society transactions 1996;24(1):19S.
1996: Andrew W Munro; John R Coggins; J Gordon Lindsay; Simon Daff; Stephen K Chapman
Formation of flavin semiquinone during the reduction of P450 BM3 reductase domain with NADPH.
Biochemical Society transactions 1996;24(1):18S.
1996: Andrew W Munro; John R Coggins; J Gordon Lindsay
Inhibition of flavin reoxidation in P450 BM3 by diphenyliodonium chloride.
Biochemical Society transactions 1996;24(1):17S.
1995: Andrew W Munro; J Gordon Lindsay; John R Coggins; Sharon M Kelly; Nicholas C Price
NADPH oxidase activity of cytochrome P-450 BM3 and its constituent reductase domain.
Biochimica et biophysica acta 1995;1231(3):255-64.
1994: Andrew W Munro; K Malarkey; J McKnight; Andrew J Thomson; Sharon M Kelly; Nicholas C Price; J Gordon Lindsay; John R Coggins; J S Miles
The role of tryptophan 97 of cytochrome P450 BM3 from Bacillus megaterium in catalytic function. Evidence against the 'covalent switching' hypothesis of P-450 electron transfer.
The Biochemical journal 1994;303 ( Pt 2)():423-8.
1994: Andrew W Munro; J Gordon Lindsay; John R Coggins; Sharon M Kelly; Nicholas C Price
Structural and enzymological analysis of the interaction of isolated domains of cytochrome P-450 BM3.
FEBS letters 1994;343(1):70-4.
1994: Andrew W Munro; J Gordon Lindsay; J R Coggins; I MacDonald; W E Smith; B N Rospendowski
Resonance Raman spectroscopic studies on intact cytochrome P450 BM3.
Biochemical Society transactions 1994;22(1):54S.
1993: Andrew W Munro; J Gordon Lindsay; John R Coggins
Alkane metabolism by cytochrome P450 BM3.
Biochemical Society transactions 1993;21(4):412S.
1993: Andrew W Munro; John R Coggins; J Gordon Lindsay
A novel inhibitor of cytochrome P450 BM3.
Biochemical Society transactions 1993;21(4):411S.
1993: Andrew W Munro; John R Coggins; J Gordon Lindsay
Regional saturation mutagenesis as an approach to identification of substrate specificity determinants in cytochrome P450 BM3.
Biochemical Society transactions 1993;21(4):409S.
1993: Andrew W Munro
Purification schemes for the constituent domains of cytochrome P450 BM3 in E. coli.
Biochemical Society transactions 1993;21 ( Pt 3)(3):316S.
1993: J McKnight; Myles R Cheesman; Andrew J Thomson; J S Miles; Andrew W Munro
Identification of charge-transfer transitions in the optical spectrum of low-spin ferric cytochrome P-450 Bacillus megaterium.
European journal of biochemistry / FEBS 1993;213(2):683-7.
1993: Andrew W Munro; K Malarkey; J S Miles
Investigating the function of cytochrome P450 BM-3: a role for the phylogenetically conserved tryptophan residue?
Biochemical Society transactions 1993;21(1):66S.
1992: J S Miles; Andrew W Munro; B N Rospendowski; W E Smith; J McKnight; Andrew J Thomson
Domains of the catalytically self-sufficient cytochrome P-450 BM-3. Genetic construction, overexpression, purification and spectroscopic characterization.
The Biochemical journal 1992;288 ( Pt 2)():503-9.