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Akira Murakami

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Hiroaki Kamachi; Akira Murakami; Kazuma Murakami; Yu Nakagawa; Nobutaka Suzuki; Keisuke Tanaka; Harukuni Tokuda; Ryo C Yanagita; Kazuhiro Irie
Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.
Akira Murakami
Modulation of protein quality control systems by food phytochemicals.
Akira Murakami; Ikuyo Furukawa; Shingo Miyamoto; Takuji Tanaka; Hajime Ohigashi
Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis.

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2013: Hiroaki Kamachi; Akira Murakami; Kazuma Murakami; Yu Nakagawa; Nobutaka Suzuki; Keisuke Tanaka; Harukuni Tokuda; Ryo C Yanagita; Kazuhiro Irie
Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.
Bioorganic & medicinal chemistry 2013;21(10):2695-702.
2013: Akira Murakami
Modulation of protein quality control systems by food phytochemicals.
Journal of clinical biochemistry and nutrition 2013;52(3):215-27.
2013: Akira Murakami; Ikuyo Furukawa; Shingo Miyamoto; Takuji Tanaka; Hajime Ohigashi
Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis.
BioFactors (Oxford, England) 2013;39(2):221-32.
2013: Kohta Ohnishi; Erina Nakahata; Kazuhiro Irie; Akira Murakami
Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy.
Biochemical and biophysical research communications 2013;430(2):616-22.
2013: Kohta Ohnishi; Junji Terao; Erina Nakahata; Tsutomu Nakayama; Shinya Ohkura; Minoru Akiyama; Yasutaka Ikeda; Kazuhiro Irie; Takeshi Ishii; Akari Ishisaka; Yoshichika Kawai; Noriyuki Kioka; Shinya Matsumoto; Taiki Mori; Akira Murakami
Non-specific protein modifications by a phytochemical induce heat shock response for self-defense.
PloS one 2013;8(3):e58641.
2012: Yuki Ikeda; Kazuhiro Irie; Noriyuki Kioka; Ryoichi Yamaji; Akira Murakami
Glyceraldehyde-3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability.
Archives of biochemistry and biophysics 2012;528(2):141-7.
2012: Hirotaka Sekiguchi; Fumiyo Takabayashi; Kazuhiro Irie; Akira Murakami
Auraptene attenuates gastritis via reduction of Helicobacter pylori colonization and pro-inflammatory mediator production in C57BL/6 mice.
Journal of medicinal food 2012;15(7):658-63.
2012: Hirofumi Inoue; Mari Maeda-Yamamoto; Atsushi Nesumi; Akira Murakami
Delphinidin-3-O-galactoside protects mouse hepatocytes from (-)-epigallocatechin-3-gallate-induced cytotoxicity via up-regulation of heme oxygenase-1 and heat shock protein 70.
Nutrition research (New York, N.Y.) 2012;32(5):357-64.
2012: Satoko Akiyama; Mari Maeda-Yamamoto; Atsushi Nesumi; Mariko Uehara; Akira Murakami
Effects of anthocyanin-rich tea "Sunrouge" on dextran sodium sulfate-induced colitis in mice.
BioFactors (Oxford, England) 2012;38(3):226-33.
2012: Akira Murakami; Kohta Ohnishi
Target molecules of food phytochemicals: food science bound for the next dimension.
Food & function 2012;3(5):462-76.
2012: Sayo Ueno; Ryo C Yanagita; Takeshi Fujiwara; Akira Murakami; Kazuma Murakami; Nobutaka Suzuki; Harukuni Tokuda; Kazuhiro Irie
Identification and biological activities of bryostatins from Japanese bryozoan.
Bioscience, biotechnology, and biochemistry 2012;76(5):1041-3.
2011: Hirofumi Inoue; Mari Maeda-Yamamoto; Atsushi Nesumi; Takuji Tanaka; Satoko Akiyama; Akira Murakami
High-dose green tea polyphenols induce nephrotoxicity in dextran sulfate sodium-induced colitis mice by down-regulation of antioxidant enzymes and heat-shock protein expressions.
Cell stress & chaperones 2011;16(6):653-62.
2011: Amane Takahashi; Norio Yamamoto; Akira Murakami
Cardamonin suppresses nitric oxide production via blocking the IFN-γ/STAT pathway in endotoxin-challenged peritoneal macrophages of ICR mice.
Life sciences 2011;89(9-10):337-42.
2011: Yu Nakagawa; Harukuni Tokuda; Ryo C Yanagita; Masayuki Kikumori; Akira Murakami; Hiroshi Nagai; Kazuhiro Irie
Synthesis and biological evaluation of the 12,12-dimethyl derivative of Aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin.
Bioscience, biotechnology, and biochemistry 2011;75(6):1167-73.
2010: Ryo C Yanagita; Hiroaki Kamachi; Keisuke Tanaka; Akira Murakami; Yu Nakagawa; Harukuni Tokuda; Hiroshi Nagai; Kazuhiro Irie
Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity.
Bioorganic & medicinal chemistry letters 2010;20(20):6064-6.
2010: Michiko Yasuda; Nancy H Colburn; Kazuhiro Irie; Daniela Rübsamen; Tobias Schmid; Akira Murakami
Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment.
Molecular carcinogenesis 2010;49(9):837-48.
2010: Toru Okubo; Kazuto Washida; Akira Murakami
Phenethyl isothiocyanate suppresses nitric oxide production via inhibition of phosphoinositide 3-kinase/Akt-induced IFN-gamma secretion in LPS-activated peritoneal macrophages.
Molecular nutrition & food research 2010;54(9):1351-60.
2010: S Miyamoto; Takuji Tanaka; Akira Murakami
Increased visceral fat mass and insulin signaling in colitis-related colon carcinogenesis model mice.
Chemico-biological interactions 2010;183(2):271-5.
2010: S Miyamoto; Yumiko Yasui; Hajime Ohigashi; Takuji Tanaka; Akira Murakami
Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.
Chemico-biological interactions 2010;183(2):276-83.
2010: Hirotaka Sekiguchi; Kazuhiro Irie; Akira Murakami
Suppression of CD74 expression and Helicobacter pylori adhesion by auraptene targeting serum starvation-activated ERK1/2 in NCI-N87 gastric carcinoma cells.
Bioscience, biotechnology, and biochemistry 2010;74(5):1018-24.
2010: Michiko Yasuda; Kazuhiro Irie; Akira Murakami
Inhibition by genistein of the lipopolysaccharide-induced down-regulation of programmed cell death 4 in RAW 264.7 mouse macrophages.
Bioscience, biotechnology, and biochemistry 2010;74(5):1095-7.
2010: Mihye Kim; Akira Murakami; Shingo Miyamoto; Takuji Tanaka; Hajime Ohigashi
The modifying effects of green tea polyphenols on acute colitis and inflammation-associated colon carcinogenesis in male ICR mice.
BioFactors (Oxford, England) 2010;36(1):43-51.
2009: Kohta Ohnishi; Kazuhiro Irie; Akira Murakami
In vitro covalent binding proteins of zerumbone, a chemopreventive food factor.
Bioscience, biotechnology, and biochemistry 2009;73(8):1905-7.
2009: Michiko Yasuda; Takashi Nishizawa; Hajime Ohigashi; Takuji Tanaka; De-Xing Hou; Nancy H Colburn; Akira Murakami
Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction.
Carcinogenesis 2009;30(7):1209-16.
2009: Yu Nakagawa; Ryo C Yanagita; Naoko Hamada; Akira Murakami; Hideyuki Takahashi; Naoaki Saito; Hiroshi Nagai; Kazuhiro Irie
A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity.
Journal of the American Chemical Society 2009;131(22):7573-9.
2009: Akira Murakami
Chemoprevention with phytochemicals targeting inducible nitric oxide synthase.
Forum of nutrition 2009;61():193-203.
2008: Akira Murakami; Hitoshi Ashida; Junji Terao
Multitargeted cancer prevention by quercetin.
Cancer letters 2008;269(2):315-25.
2008: Hirotaka Sekiguchi; Kazuto Washida; Akira Murakami
Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells.
Journal of clinical biochemistry and nutrition 2008;43(2):109-17.
2008: Yasutaka Ikeda; Akira Murakami; Hajime Ohigashi
Strain differences regarding susceptibility to ursolic acid-induced interleukin-1beta release in murine macrophages.
Life sciences 2008;83(1-2):43-9.
2008: Shingo Miyamoto; Yumiko Yasui; Takuji Tanaka; Hajime Ohigashi; Akira Murakami
Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice.
Carcinogenesis 2008;29(5):1057-63.
2008: Shingo Miyamoto; Yumiko Yasui; Mihye Kim; Shigeyuki Sugie; Akira Murakami; Rikako Ishigamori-Suzuki; Takuji Tanaka
A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies.
Carcinogenesis 2008;29(2):418-26.
2008: Keiko Momma; Yuko Masuzawa; Naomi Nakai; Moeko Chujo; Akira Murakami; Noriyuki Kioka; Yasunori Kiyama; Toru Akita; Masaya Nagao
Direct interaction of Cucurbitacin E isolated from Alsomitra macrocarpa to actin filament.
Cytotechnology 2008;56(1):33-9.
2008: Yasutaka Ikeda; Akira Murakami; Hajime Ohigashi
Ursolic acid: an anti- and pro-inflammatory triterpenoid.
Molecular nutrition & food research 2008;52(1):26-42.
2007: Akira Murakami; Hajime Ohigashi
Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals.
International journal of cancer. Journal international du cancer 2007;121(11):2357-63.
2007: Mihye Kim; Akira Murakami; Hajime Ohigashi
Modifying effects of dietary factors on (-)-epigallocatechin-3-gallate-induced pro-matrix metalloproteinase-7 production in HT-29 human colorectal cancer cells.
Bioscience, biotechnology, and biochemistry 2007;71(10):2442-50.
2007: Ki Han Kwon; Hajime Ohigashi; Akira Murakami
Dextran sulfate sodium enhances interleukin-1 beta release via activation of p38 MAPK and ERK1/2 pathways in murine peritoneal macrophages.
Life sciences 2007;81(5):362-71.
2007: Yasutaka Ikeda; Akira Murakami; Yoshinori Fujimura; Hirofumi Tachibana; Koji Yamada; Daisaku Masuda; Ken-Ichi Hirano; Shizuya Yamashita; Hajime Ohigashi
Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4854-64.
2007: Ai Eguchi; Yuki Kaneko; Akira Murakami; Hajime Ohigashi
Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.
Bioscience, biotechnology, and biochemistry 2007;71(4):935-45.
2007: Ai Eguchi; Akira Murakami; Shiming Li; Chi-Tang Ho; Hajime Ohigashi
Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.
BioFactors (Oxford, England) 2007;31(2):107-16.
2007: Akira Murakami; Meiyu Song; Shin-Ichi Katsumata; Mariko Uehara; Kazuharu Suzuki; Hajime Ohigashi
Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: possible involvement of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis regulation.
BioFactors (Oxford, England) 2007;30(3):179-92.
2007: Akira Murakami; Meiyu Song; Hajime Ohigashi
Phenethyl isothiocyanate suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages.
BioFactors (Oxford, England) 2007;30(1):1-11.
2006: Kyuichi Kawabata; Akira Murakami; Hajime Ohigashi
Auraptene decreases the activity of matrix metalloproteinases in dextran sulfate sodium-induced ulcerative colitis in ICR mice.
Bioscience, biotechnology, and biochemistry 2006;70(12):3062-5.
2006: Kyuichi Kawabata; Akira Murakami; Hajime Ohigashi
Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism.
FEBS letters 2006;580(22):5288-94.
2006: Ai Eguchi; Akira Murakami; Hajime Ohigashi
Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.
FEBS letters 2006;580(13):3321-8.
2006: Shingo Miyamoto; Hiroyuki Kohno; Rikako Suzuki; Shigeyuki Sugie; Akira Murakami; Hajime Ohigashi; Takuji Tanaka
Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats.
Oncology reports 2006;15(5):1169-73.
2006: Yasutaka Ikeda; Akira Murakami; Takashi Nishizawa; Hajime Ohigashi
Ursolic acid enhances cyclooxygenases and tumor necrosis factor-alpha expression in mouse skin.
Bioscience, biotechnology, and biochemistry 2006;70(4):1033-7.
2006: Akira Murakami; Hajime Ohigashi
Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells.
Biological chemistry 2006;387(4):387-92.
2005: Akira Murakami; Tomohiro Shigemori; Hajime Ohigashi
Zingiberaceous and citrus constituents, 1'-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action.
The Journal of nutrition 2005;135(12 Suppl):2987S-2992S.
2005: Ai Eguchi; Akira Murakami; Hajime Ohigashi
Novel bioassay system for evaluating anti-oxidative activities of food items: use of basolateral media from differentiated Caco-2 cells.
Free radical research 2005;39(12):1367-75.
2005: Ki Han Kwon; Akira Murakami; Ryohei Hayashi; Hajime Ohigashi
Interleukin-1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis.
Biochemical and biophysical research communications 2005;337(2):647-54.
2005: Yasutaka Ikeda; Akira Murakami; Hajime Ohigashi
Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages.
Biochemical pharmacology 2005;70(10):1497-505.
2005: Ha Won Kim; Akira Murakami; Masako Abe; Yoshio Ozawa; Yasujiro Morimitsu; Marshall V Williams; Hajime Ohigashi
Suppressive effects of mioga ginger and ginger constituents on reactive oxygen and nitrogen species generation, and the expression of inducible pro-inflammatory genes in macrophages.
Antioxidants & redox signaling 2005;7(11-12):1621-9.
2005: Shiho Nakagiri; Akira Murakami; Shinji Takada; Tetsu Akiyama; Shin Yonehara
Viral FLIP enhances Wnt signaling downstream of stabilized beta-catenin, leading to control of cell growth.
Molecular and cellular biology 2005;25(21):9249-58.
2005: Akira Murakami; Takashi Nishizawa; Kahori Egawa; Teruo Kawada; Yasushi Nishikawa; Kazuo Uenakai; Hajime Ohigashi
New class of linoleic acid metabolites biosynthesized by corn and rice lipoxygenases: suppression of proinflammatory mediator expression via attenuation of MAPK- and Akt-, but not PPARgamma-, dependent pathways in stimulated macrophages.
Biochemical pharmacology 2005;70(9):1330-42.
2005: Akira Murakami; Hisashi Ishida; Kimie Kobo; Ikuyo Furukawa; Yasutaka Ikeda; Megumi Yonaha; Yohko Aniya; Hajime Ohigashi
Suppressive effects of Okinawan food items on free radical generation from stimulated leukocytes and identification of some active constituents: implications for the prevention of inflammation-associated carcinogenesis.
Asian Pacific journal of cancer prevention : APJCP 2005;6(4):437-48.
2005: Mihye Kim; Akira Murakami; Kyuichi Kawabata; Hajime Ohigashi
(-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells.
Carcinogenesis 2005;26(9):1553-62.
2005: Kyuichi Kawabata; Akira Murakami; Hajime Ohigashi
Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells.
Bioscience, biotechnology, and biochemistry 2005;69(2):307-14.
2005: Ki Han Kwon; Akira Murakami; Takuji Tanaka; Hajime Ohigashi
Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression.
Biochemical pharmacology 2005;69(3):395-406.
2005: Ahamed El-Salmawy; Tatsuya Kitagawa; In Kap Ko; Akira Murakami; Yoshiharu Kimura; Tetsuji Yamaoka; Hiroo Iwata
Preparation and properties of ProNectin F-coated biodegradable hollow fibers.
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 2005;8(4):245-51.
2004: Akira Murakami; Huiqing Shen; Sanami Ishida; Clive Dickson
SOX7 and GATA-4 are competitive activators of Fgf-3 transcription.
The Journal of biological chemistry 2004;279(27):28564-73.
2004: Akira Murakami; Takuji Tanaka; Ji-Yoon Lee; Young-Joon Surh; Ha Won Kim; Kyuichi Kawabata; Yoshimasa Nakamura; Suratwadee Jiwajinda; Hajime Ohigashi
Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice.
International journal of cancer. Journal international du cancer 2004;110(4):481-90.
2004: Ki Han Kwon; Akira Murakami; Hajime Ohigashi
Suppressive effects of natural and synthetic agents on dextran sulfate sodium-induced interleukin-1beta release from murine peritoneal macrophages.
Bioscience, biotechnology, and biochemistry 2004;68(2):436-9.
2004: Hajime Ohigashi; Akira Murakami
Cancer prevention with food factors: alone and in combination.
BioFactors (Oxford, England) 2004;22(1-4):49-55.
2004: Akira Murakami; Masaaki Miyamoto; Hajime Ohigashi
Zerumbone, an anti-inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell lines.
BioFactors (Oxford, England) 2004;21(1-4):95-101.
2004: Ki Han Kwon; Akira Murakami; Takuji Tanaka; Hajime Ohigashi
Suppressive activity of a fermented grain food product on dextran sulfate sodium-induced experimental colitis in mice.
BioFactors (Oxford, England) 2004;21(1-4):179-84.
2004: Keiko Sakata; Akira Hara; Yoshinobu Hirose; Yasuhiro Yamada; Toshiya Kuno; Masaki Katayama; Koujiro Yoshida; Qiao Zheng; Akira Murakami; Hajime Ohigashi; Kohei Ikemoto; Koichi Koshimizu; Takuji Tanaka; Hideki Mori
Dietary supplementation of the citrus antioxidant auraptene inhibits N,N-diethylnitrosamine-induced rat hepatocarcinogenesis.
Oncology 2004;66(3):244-52.
2004: Ha Won Kim; Akira Murakami; Marshall V Williams; Hajime Ohigashi
Suppressive effects of selected antioxidants on the activated leukocytes-induced mutagenesis in the co-culture assay systems.
Bioscience, biotechnology, and biochemistry 2004;68(1):238-42.
2003: Akira Murakami; Ryohei Hayashi; Takuji Tanaka; Ki Han Kwon; Hajime Ohigashi; Ratu Safitri; Takuji Takana
Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination.
Biochemical pharmacology 2003;66(7):1253-61.
2003: Akira Murakami; Kazuhiko Matsumoto; Koichi Koshimizu; Hajime Ohigashi
Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages.
Cancer letters 2003;195(1):17-25.
2003: Akira Murakami; Daisuke Takahashi; Kazuma Hagihara; Koichi Koshimizu; Hajime Ohigashi
Combinatorial effects of nonsteroidal anti-inflammatory drugs and food constituents on production of prostaglandin E2 and tumor necrosis factor-alpha in RAW264.7 murine macrophages.
Bioscience, biotechnology, and biochemistry 2003;67(5):1056-62.
2003: Akira Murakami; Daisuke Takahashi; Koichi Koshimizu; Hajime Ohigashi
Synergistic suppression of superoxide and nitric oxide generation from inflammatory cells by combined food factors.
Mutation research 2003;523-524():151-61.
2003: Ha Won Kim; Akira Murakami; Marshall V Williams; Hajime Ohigashi
Mutagenicity of reactive oxygen and nitrogen species as detected by co-culture of activated inflammatory leukocytes and AS52 cells.
Carcinogenesis 2003;24(2):235-41.
2002: Qiao Zheng; Yoshinobu Hirose; Naoki Yoshimi; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; Keiko Sakata; Yuji Matsumoto; Yoshikatsu Sayama; Hideki Mori
Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells.
Journal of cancer research and clinical oncology 2002;128(10):539-46.
2002: Suratwadee Jiwajinda; Vilai Santisopasri; Akira Murakami; Hiromu Sugiyama; Monique Gasquet; Elias Riad; Guy Balansard; Hajime Ohigashi
In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia.
Journal of ethnopharmacology 2002;82(1):55-8.
2002: Akira Murakami; Yoshimasa Nakamura; Koichi Koshimizu; Daisuke Takahashi; Kazuhiro Matsumoto; Kazuma Hagihara; Hisaji Taniguchi; Eisaku Nomura; Asao Hosoda; Takuo Tsuno; Yuko Maruta; Ha Won Kim; Kyuichi Kawabata; Hajime Ohigashi
FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: comparison with ferulic acid.
Cancer letters 2002;180(2):121-9.
2002: Asao Hosoda; Eisaku Nomura; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; Kazuhiko Mizuno; Hisaji Taniguchi
Synthesis of feruloyl-myo-insitol derivatives and their inhibitory effects on phorbol ester-induced superoxide generation and Esptein-Barr virus activation.
Bioorganic & medicinal chemistry 2002;10(6):1855-63.
2002: Akira Murakami; Daisuke Takahashi; Takashi Kinoshita; Koichi Koshimizu; Ha Won Kim; Akira Yoshihiro; Yoshimasa Nakamura; Suratwadee Jiwajinda; Junji Terao; Hajime Ohigashi
Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.
Carcinogenesis 2002;23(5):795-802.
2002: Eisaku Nomura; Asao Hosoda; Hideko Morishita; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; Hisaji Taniguchi
Synthesis of novel polyphenols consisted of ferulic and gallic acids, and their inhibitory effects on phorbol ester-induced Epstein-Barr virus activation and superoxide generation.
Bioorganic & medicinal chemistry 2002;10(4):1069-75.
2002: Akira Murakami; Sanami Ishida; Clive Dickson
GATA-4 interacts distinctively with negative and positive regulatory elements in the Fgf-3 promoter.
Nucleic acids research 2002;30(4):1056-64.
2002: Ha Won Kim; Akira Murakami; Yoshimasa Nakamura; Hajime Ohigashi
Screening of edible Japanese plants for suppressive effects on phorbol ester-induced superoxide generation in differentiated HL-60 cells and AS52 cells.
Cancer letters 2002;176(1):7-16.
2002: Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; Shigeru Kuwahara; Wataru Kuki; Yasuo Takahashi; Keisuke Hosotani; Satsuki Kawahara; Yumi Matsuoka
Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin.
BioFactors (Oxford, England) 2002;16(3-4):73-82.
2001: Suratwadee Jiwajinda; Vilai Santisopasri; Akira Murakami; N Hirai; Hajime Ohigashi
Quassinoids from Eurycoma longifolia as plant growth inhibitors.
Phytochemistry 2001;58(6):959-62.
2001: Akira Murakami; Sanami Ishida; J Thurlow; Jean-Michel Revest; Clive Dickson
SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter.
Nucleic acids research 2001;29(16):3347-55.
2001: Akira Murakami; S Kuwahara; Yoshito Takahashi; C Ito; H Furukawa; M Ju-Ichi; Koichi Koshimizu
In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits.
Bioscience, biotechnology, and biochemistry 2001;65(1):194-7.
2000: Akira Murakami; K Kawabata; T Koshiba; G Gao; Yoshimasa Nakamura; Koichi Koshimizu; Hajime Ohigashi
Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon-gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha.
Cancer research 2000;60(22):6326-31.
2000: OK Kim; Akira Murakami; Daisuke Takahashi; Yoshimasa Nakamura; K Torikai; Ha Won Kim; Hajime Ohigashi
An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin.
Bioscience, biotechnology, and biochemistry 2000;64(11):2504-7.
2000: OK Kim; Akira Murakami; Yoshimasa Nakamura; Ha Won Kim; H Ohigash
Inhibition by (+)-persenone [corrected] A-related compounds of nitric oxide and superoxide generation from inflammatory leukocytes.
Bioscience, biotechnology, and biochemistry 2000;64(11):2500-3.
2000: Yoshimasa Nakamura; K Torikai; Y Ohto; Akira Murakami; Tomoyuki Tanaka; Hajime Ohigashi
A simple phenolic antioxidant protocatechuic acid enhances tumor promotion and oxidative stress in female ICR mouse skin: dose-and timing-dependent enhancement and involvement of bioactivation by tyrosinase.
Carcinogenesis 2000;21(10):1899-907.
2000: Akira Murakami; Yoshimasa Nakamura; T Tanaka; K Kawabata; Daisuke Takahashi; Koichi Koshimizu; Hajime Ohigashi
Suppression by citrus auraptene of phorbol ester-and endotoxin-induced inflammatory responses: role of attenuation of leukocyte activation.
Carcinogenesis 2000;21(10):1843-50.
2000: Akira Murakami; Yoshimasa Nakamura; K Torikai; T Tanaka; T Koshiba; Koichi Koshimizu; S Kuwahara; Yoshito Takahashi; K Ogawa; M Yano; H Tokuda; H Nishino; Y Mimaki; Y Sashida; S Kitanaka; Hajime Ohigashi
Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice.
Cancer research 2000;60(18):5059-66.
2000: Yoshimasa Nakamura; Yasujiro Morimitsu; T Uzu; Hajime Ohigashi; Akira Murakami; Y Naito; Y Nakagawa; Toshihiko Osawa; K Uchida
A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates.
Cancer letters 2000;157(2):193-200.
2000: Akira Murakami; Megumi Kadota; Daisuke Takahashi; Hisaji Taniguchi; Eisaku Nomura; Asao Hosoda; Takuo Tsuno; Yuko Maruta; Hajime Ohigashi; Koichi Koshimizu
Suppressive effects of novel ferulic acid derivatives on cellular responses induced by phorbol ester, and by combined lipopolysaccharide and interferon-gamma.
Cancer letters 2000;157(1):77-85.
2000: Asao Hosoda; Eisaku Nomura; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; Kazuhiko Mizuno; Hisaji Taniguchi
Synthesis of feruloyl-myo-inositols and their inhibitory effects on superoxide generation.
Bioorganic & medicinal chemistry letters 2000;10(13):1439-42.
2000: OK Kim; Akira Murakami; Yoshimasa Nakamura; N Takeda; H Yoshizumi; Hajime Ohigashi
Novel nitric oxide and superoxide generation inhibitors, persenone A and B, from avocado fruit.
Journal of agricultural and food chemistry 2000;48(5):1557-63.
2000: Akira Murakami; K Toyota; S Ohura; Koichi Koshimizu; Hajime Ohigashi
Structure-activity relationships of (1'S)-1'-acetoxychavicol acetate, a major constituent of a southeast Asian condiment plant Languas galanga, on the inhibition of tumor-promoter-induced Epstein-Barr virus activation.
Journal of agricultural and food chemistry 2000;48(5):1518-23.
2000: Kunihiro Kawabata; Takuji Tanaka; T Yamamoto; Akira Hara; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; G D Stoner; Hideki Mori
Suppression of N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis by dietary feeding of auraptene.
Journal of experimental & clinical cancer research : CR 2000;19(1):45-52.
2000: Akira Murakami; M Nakashima; T Koshiba; T Maoka; H Nishino; M Yano; T Sumida; O K Kim; Koichi Koshimizu; Hajime Ohigashi
Modifying effects of carotenoids on superoxide and nitric oxide generation from stimulated leukocytes.
Cancer letters 2000;149(1-2):115-23.
2000: Kunihiro Kawabata; Takuji Tanaka; T Yamamoto; Jun Ushida; Akira Hara; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; G D Stoner; Hideki Mori
Suppression of N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis by dietary feeding of 1'-acetoxychavicol acetate.
Japanese journal of cancer research : Gann 2000;91(2):148-55.
2000: Yoshimasa Nakamura; Hajime Ohigashi; S Masuda; Akira Murakami; Yasujiro Morimitsu; Y Kawamoto; Toshihiko Osawa; M Imagawa; K Uchida
Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates.
Cancer research 2000;60(2):219-25.
2000: Akira Murakami; G Gao; M Omura; M Yano; C Ito; H Furukawa; Daisuke Takahashi; Koichi Koshimizu; Hajime Ohigashi
1,1-Dimethylallylcoumarins potently suppress both lipopolysaccharide- and interferon-gamma-induced nitric oxide generation in mouse macrophage RAW 264.7 cells.
Bioorganic & medicinal chemistry letters 2000;10(1):59-62.
2000: Akira Murakami; Yoshimasa Nakamura; Y Ohto; M Yano; T Koshiba; Koichi Koshimizu; H Tokuda; H Nishino; Hajime Ohigashi
Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid.
BioFactors (Oxford, England) 2000;12(1-4):187-92.
2000: Akira Murakami; K Wada; N Ueda; K Sasaki; M Haga; Wataru Kuki; Yoshito Takahashi; H Yonei; Koichi Koshimizu; Hajime Ohigashi
In vitro absorption and metabolism of a citrus chemopreventive agent, auraptene, and its modifying effects on xenobiotic enzyme activities in mouse livers.
Nutrition and cancer 2000;36(2):191-9.
2000: Akira Murakami; A M Ali; K Mat-Salleh; Koichi Koshimizu; Hajime Ohigashi
Screening for the in vitro anti-tumor-promoting activities of edible plants from Malaysia.
Bioscience, biotechnology, and biochemistry 2000;64(1):9-16.
1999: Akira Murakami; M Takahashi; Suratwadee Jiwajinda; Koichi Koshimizu; Hajime Ohigashi
Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation.
Bioscience, biotechnology, and biochemistry 1999;63(10):1811-2.
1999: Takuji Tanaka; H Sugiura; R Inaba; A Nishikawa; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi
Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice.
Carcinogenesis 1999;20(8):1471-6.
1999: Akira Murakami; J Thurlow; Clive Dickson
Retinoic acid-regulated expression of fibroblast growth factor 3 requires the interaction between a novel transcription factor and GATA-4.
The Journal of biological chemistry 1999;274(24):17242-8.
1999: Yoshimasa Nakamura; N Kawamoto; Y Ohto; K Torikai; Akira Murakami; Hajime Ohigashi
A diacetylenic spiroketal enol ether epoxide, AL-1, from Artemisia lactiflora inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion possibly by suppression of oxidative stress.
Cancer letters 1999;140(1-2):37-45.
1999: Yoichi Imai; T Kimura; Akira Murakami; Nobuyuki Yajima; Kazuhiro Sakamaki; Shin Yonehara
The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis.
Nature 1999;398(6730):777-85.
1999: Akira Murakami; G Gao; O K Kim; M Omura; M Yano; C Ito; H Furukawa; Suratwadee Jiwajinda; Koichi Koshimizu; Hajime Ohigashi
Identification of coumarins from the fruit of Citrus hystrix DC as inhibitors of nitric oxide generation in mouse macrophage RAW 264.7 cells.
Journal of agricultural and food chemistry 1999;47(1):333-9.
1998: Yoshimasa Nakamura; Akira Murakami; Y Ohto; K Torikai; Tomoyuki Tanaka; Hajime Ohigashi
Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1'-acetoxychavicol acetate.
Cancer research 1998;58(21):4832-9.
1998: Takuji Tanaka; Kunihiro Kawabata; M Kakumoto; Akira Hara; Akira Murakami; Wataru Kuki; Yoshito Takahashi; H Yonei; M Maeda; T Ota; S Odashima; T Yamane; Koichi Koshimizu; Hajime Ohigashi
Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes.
Cancer research 1998;58(12):2550-6.
1998: Akira Murakami; Y Kitazono; Suratwadee Jiwajinda; Koichi Koshimizu; Hajime Ohigashi
Niaziminin, a thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor-promoter-induced Epstein-Barr virus activation.
Planta medica 1998;64(4):319-23.
1998: Yoshimasa Nakamura; Y Ohto; Akira Murakami; Toshihiko Osawa; Hajime Ohigashi
Inhibitory effects of curcumin and tetrahydrocurcuminoids on the tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo.
Japanese journal of cancer research : Gann 1998;89(4):361-70.
1998: OK Kim; Akira Murakami; Yoshimasa Nakamura; Hajime Ohigashi
Screening of edible Japanese plants for nitric oxide generation inhibitory activities in RAW 264.7 cells.
Cancer letters 1998;125(1-2):199-207.
1998: Takuji Tanaka; Kunihiro Kawabata; M Kakumoto; K Matsunaga; Hideki Mori; Akira Murakami; Wataru Kuki; Yoshito Takahashi; H Yonei; K Satoh; Akira Hara; M Maeda; T Ota; S Odashima; Koichi Koshimizu; Hajime Ohigashi
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by citrus auraptene in rats.
Carcinogenesis 1998;19(3):425-31.
1998: Akira Murakami; H Morita; R Safitri; A Ramlan; Koichi Koshimizu; Hajime Ohigashi
Screening for in vitro anti-tumor-promoting activities of edible plants from Indonesia.
Cancer detection and prevention 1998;22(6):516-25.
1997: Takuji Tanaka; Kunihiro Kawabata; M Kakumoto; Hiroki Makita; Akira Hara; Hideki Mori; K Satoh; A Hara; Akira Murakami; Wataru Kuki; Yoshito Takahashi; H Yonei; Koichi Koshimizu; Hajime Ohigashi
Citrus auraptene inhibits chemically induced colonic aberrant crypt foci in male F344 rats.
Carcinogenesis 1997;18(11):2155-61.
1997: Takuji Tanaka; Kunihiro Kawabata; M Kakumoto; Hiroki Makita; K Matsunaga; Hideki Mori; K Satoh; Akira Hara; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate.
Japanese journal of cancer research : Gann 1997;88(9):821-30.
1997: Akira Murakami; Wataru Kuki; Yoshito Takahashi; H Yonei; Yoshimasa Nakamura; Y Ohto; Hajime Ohigashi; Koichi Koshimizu
Auraptene, a citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin, possibly through suppression of superoxide generation in leukocytes.
Japanese journal of cancer research : Gann 1997;88(5):443-52.
1997: Takuji Tanaka; Hiroki Makita; Toshihiko Kawamori; Kunihiro Kawabata; Hideki Mori; Akira Murakami; K Satoh; Akira Hara; Hajime Ohigashi; Koichi Koshimizu
A xanthine oxidase inhibitor 1'-acetoxychavicol acetate inhibits azoxymethane-induced colonic aberrant crypt foci in rats.
Carcinogenesis 1997;18(5):1113-8.
1996: Yoshimasa Nakamura; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi
Inhibitory effect of pheophorbide a, a chlorophyll-related compound, on skin tumor promotion in ICR mouse.
Cancer letters 1996;108(2):247-55.
1996: Hajime Ohigashi; Akira Murakami; Koichi Koshimizu
An approach to functional food: cancer preventive potential of vegetables and fruits and their active constituents.
Nutrition reviews 1996;54(11 Pt 2):S24-8.
1996: Akira Murakami; S Ohura; Y Nakamura; Koichi Koshimizu; Hajime Ohigashi
1'-Acetoxychavicol acetate, a superoxide anion generation inhibitor, potently inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in ICR mouse skin.
Oncology 1996;53(5):386-91.
1996: Yoshimasa Nakamura; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi
Identification of pheophorbide a and its related compounds as possible anti-tumor promoters in the leaves of Neptunia oleracea.
Bioscience, biotechnology, and biochemistry 1996;60(6):1028-30.
1996: M Ohnishi; Takuji Tanaka; Hiroki Makita; Toshihiko Kawamori; Hideki Mori; K Satoh; Akira Hara; Akira Murakami; Hajime Ohigashi; Koichi Koshimizu
Chemopreventive effect of a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate, on rat oral carcinogenesis.
Japanese journal of cancer research : Gann 1996;87(4):349-56.
1995: Akira Murakami; Suratwadee Jiwajinda; Koichi Koshimizu; Hajime Ohigashi
Screening for in vitro anti-tumor promoting activities of edible plants from Thailand.
Cancer letters 1995;95(1-2):139-46.
1992: Akira Murakami; S Tanaka; Hajime Ohigashi; M Hirota; R Irie; N Takeda; A Tatematsu; Koichi Koshimizu
Chalcone tetramers, lophirachalcone and alatachalcone, from Lophira alata as possible anti-tumor promoters.
Bioscience, biotechnology, and biochemistry 1992;56(5):769-72.
1991: Akira Murakami; Hajime Ohigashi; M Jisaka; M Hirota; R Irie; Koichi Koshimizu
Inhibitory effects of new types of biflavonoid-related polyphenols; lophirone A and lophiraic acid, on some tumor promoter-induced biological responses in vitro and in vivo.
Cancer letters 1991;58(1-2):101-6.