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BK Muralidhara

Research Profile

Living Beings

Desulfovibrio desulfuricans

Occupations

Thermodynamics

Chemicals & Drugs

Concepts & Ideas

Phenomena

Protein Binding

Procedures

Physiology

Protein Folding

Disorders

Protein Denaturation

Co-author Network

Publications

TOP 3
BK Muralidhara; Ling Sun; Surendra S Negi; James Halpert
Thermodynamic fidelity of the mammalian cytochrome P450 2B4 active site in binding substrates and inhibitors.
Santosh Kumar; Yonghong Zhao; Ling Sun; Surendra S Negi; James Halpert; BK Muralidhara
Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.
Yonghong Zhao; Ling Sun; BK Muralidhara; Santosh Kumar; Mark A White; C David Stout; James Halpert
Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.

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All Publications

2008: BK Muralidhara; Ling Sun; Surendra S Negi; James Halpert
Thermodynamic fidelity of the mammalian cytochrome P450 2B4 active site in binding substrates and inhibitors.
Journal of molecular biology 2008;377(1):232-45.
2007: Santosh Kumar; Yonghong Zhao; Ling Sun; Surendra S Negi; James Halpert; BK Muralidhara
Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.
Molecular pharmacology 2007;72(5):1191-9.
2007: Yonghong Zhao; Ling Sun; BK Muralidhara; Santosh Kumar; Mark A White; C David Stout; James Halpert
Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.
Biochemistry 2007;46(41):11559-67.
2007: Ganesh L Lokesh; BK Muralidhara; Surendra S Negi; Amarnath Natarajan
Thermodynamics of phosphopeptide tethering to BRCT: the structural minima for inhibitor design.
Journal of the American Chemical Society 2007;129(35):10658-9.
2007: BK Muralidhara; Surendra S Negi; James Halpert
Dissecting the thermodynamics and cooperativity of ligand binding in cytochrome P450eryF.
Journal of the American Chemical Society 2007;129(7):2015-24.
2007: BK Muralidhara; James Halpert
Thermodynamics of ligand binding to P450 2B4 and P450eryF studied by isothermal titration calorimetry.
Drug metabolism reviews 2007;39(2-3):539-56.
2006: Santosh Kumar; Ling Sun; Hong Liu; BK Muralidhara; James Halpert
Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide.
Protein engineering, design & selection : PEDS 2006;19(12):547-54.
2006: BK Muralidhara; Ramesh Rathinakumar; Pernilla Wittung-Stafshede
Folding of Desulfovibrio desulfuricans flavodoxin is accelerated by cofactor fly-casting.
Archives of biochemistry and biophysics 2006;451(1):51-8.
2006: BK Muralidhara; Surendra S Negi; Christopher C Chin; Werner Braun; James Halpert
Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modeling.
The Journal of biological chemistry 2006;281(12):8051-61.
2006: Yonghong Zhao; Mark A White; BK Muralidhara; Ling Sun; James Halpert; C David Stout
Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.
The Journal of biological chemistry 2006;281(9):5973-81.
2006: Miguel A de Los Rios; BK Muralidhara; David Wildes; Tobin R Sosnick; Susan Marqusee; Pernilla Wittung-Stafshede; Kevin W Plaxco; Ingo Ruczinski
On the precision of experimentally determined protein folding rates and phi-values.
Protein science : a publication of the Protein Society 2006;15(3):553-63.
2005: BK Muralidhara; Mingzhi Chen; Jianpeng Ma; Pernilla Wittung-Stafshede
Effect of inorganic phosphate on FMN binding and loop flexibility in Desulfovibrio desulfuricans apo-flavodoxin.
Journal of molecular biology 2005;349(1):87-97.
2005: BK Muralidhara; Pernilla Wittung-Stafshede
FMN binding and unfolding of Desulfovibrio desulfuricans flavodoxin: "hidden" intermediates at low denaturant concentrations.
Biochimica et biophysica acta 2005;1747(2):239-50.
2005: Catherine L Higgins; BK Muralidhara; Pernilla Wittung-Stafshede
How do cofactors modulate protein folding?
Protein and peptide letters 2005;12(2):165-70.
2004: BK Muralidhara; Pernilla Wittung-Stafshede
Thermal unfolding of Apo and Holo Desulfovibrio desulfuricans flavodoxin: cofactor stabilizes folded and intermediate states.
Biochemistry 2004;43(40):12855-64.
2003: BK Muralidhara; Pernilla Wittung-Stafshede
Can cofactor-binding sites in proteins be flexible? Desulfovibrio desulfuricans flavodoxin binds FMN dimer.
Biochemistry 2003;42(44):13074-80.