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Toshihiko Murayama

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Living Beings

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Drug Dose-Response Relationship

Anatomy

Phenomena

Muscle Contraction

Physiology

Cell Death

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Co-Publications
Name
34
Horie, Syunji
18
Hirabayashi, Tetsuya
15
Nakamura, Hiroyuki
12
Watanabe, Kazuo
11
Tsuchiya, Shizuko
11
Saito, Takeshi
11
Someya, Akiyoshi
11
Fujino, Hiromichi
9
Okuma, Yasunobu
9
Shimizu, Masaya
7
Takayama, Hiromitsu
7
Nomura, Yasuyuki
7
Matsumoto, Kenjiro
6
Akiyama, Nobuteru
5
Hatori, Yoshio

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Publications

TOP 3
Matsumoto Kenjiro; Kurosawa Emi; Terui Hiroyuki; Hosoya Takuji; Tashima Kimihito; Murayama Toshihiko; Priestley John V; Horie Syunji
Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon.
Kurosawa Takeshi; Nakamura Hiroyuki; Yamaura Erika; Fujino Hiromichi; Matsuzawa Yasuo; Kawashima Tatsuo; Murayama Toshihiko
Cytotoxicity induced by inhibition of thioredoxin reductases via multiple signaling pathways: role of cytosolic phospholipase A(2)alpha-dependent and -independent release of arachidonic acid.
Shimizu Masaya; Muramatsu Yuki; Tada Eiko; Kurosawa Takeshi; Yamaura Erika; Nakamura Hiroyuki; Fujino Hiromichi; Houjyo Yuuya; Miyasaka Yuri; Koide Yuuki; Nishida Atsushi; Murayama Toshihiko
Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity relationship.

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All Publications

2009: Matsumoto Kenjiro; Kurosawa Emi; Terui Hiroyuki; Hosoya Takuji; Tashima Kimihito; Murayama Toshihiko; Priestley John V; Horie Syunji
Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon.
American journal of physiology. Gastrointestinal and liver physiology 2009;297(2):G348-60.
2009: Kurosawa Takeshi; Nakamura Hiroyuki; Yamaura Erika; Fujino Hiromichi; Matsuzawa Yasuo; Kawashima Tatsuo; Murayama Toshihiko
Cytotoxicity induced by inhibition of thioredoxin reductases via multiple signaling pathways: role of cytosolic phospholipase A(2)alpha-dependent and -independent release of arachidonic acid.
Journal of cellular physiology 2009;219(3):606-16.
2009: Shimizu Masaya; Muramatsu Yuki; Tada Eiko; Kurosawa Takeshi; Yamaura Erika; Nakamura Hiroyuki; Fujino Hiromichi; Houjyo Yuuya; Miyasaka Yuri; Koide Yuuki; Nishida Atsushi; Murayama Toshihiko
Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity relationship.
Journal of pharmacological sciences 2009;109(3):431-43.
2009: Shimizu Masaya; Tada Eiko; Makiyama Tomohiko; Yasufuku Kana; Moriyama Yuta; Fujino Hiromichi; Nakamura Hiroyuki; Murayama Toshihiko
Effects of ceramide, ceramidase inhibition and expression of ceramide kinase on cytosolic phospholipase A2alpha; additional role of ceramide-1-phosphate in phosphorylation and Ca2+ signaling.
Cellular signalling 2009;21(3):440-7.
2009: Murakami Ikuo; Hamada Yuri; Yamane Satoshi; Fujino Hiromichi; Horie Shunji; Murayama Toshihiko
Nicotine-induced neurogenic relaxation in the mouse colon: changes with dextran sodium sulfate-induced colitis.
Journal of pharmacological sciences 2009;109(1):128-38.
2008: Taniguchi Tomoko; Fujino Hiromichi; Israel Davelene D; Regan John W; Murayama Toshihiko
Human EP3(I) prostanoid receptor induces VEGF and VEGF receptor-1 mRNA expression.
Biochemical and biophysical research communications 2008;377(4):1173-8.
2008: Orido Takashi; Fujino Hiromichi; Hasegawa Yuta; Toyomura Kaori; Kawashima Tatsuo; Murayama Toshihiko
Indomethacin decreases arachidonic acid uptake in HCA-7 human colon cancer cells.
Journal of pharmacological sciences 2008;108(3):389-92.
2008: Mashimo Masato; Hirabayashi Tetsuya; Murayama Toshihiko; Shimizu Takao
Cytosolic PLA2(alpha) activation in Purkinje neurons and its role in AMPA-receptor trafficking.
Journal of cell science 2008;121(Pt 18):3015-24.
2008: Matsumoto Kenjiro; Takayama Hiromitsu; Narita Minoru; Nakamura Atsushi; Suzuki Masami; Suzuki Tsutomu; Murayama Toshihiko; Wongseripipatana Sumphan; Misawa Kaori; Kitajima Mariko; Tashima Kimihito; Horie Syunji
MGM-9 [(E)-methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine: a novel dual-acting mu- and kappa-opioid agonist with potent antinociceptive and weak rewarding effects in mice.
Neuropharmacology 2008;55(2):154-65.
2008: Nabemoto Maiko; Mashimo Masato; Someya Akiyoshi; Nakamura Hiroyuki; Hirabayashi Tetsuya; Fujino Hiromichi; Kaneko Masayuki; Okuma Yasunobu; Saito Takeshi; Yamaguchi Naoto; Murayama Toshihiko
Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha.
European journal of pharmacology 2008;590(1-3):1-11.
2008: Shimizu Masaya; Nakamura Hiroyuki; Hirabayashi Tetsuya; Suganami Akiko; Tamura Yutaka; Murayama Toshihiko
Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2alpha (cPLA2alpha) by calmodulin-dependent protein kinase: possible interaction with catalytic domain A of cPLA2alpha.
Cellular signalling 2008;20(5):815-24.
2008: Shimizu Masaya; Matsumoto Yuka; Kurosawa Takeshi; Azuma Chihiro; Enomoto Masato; Nakamura Hiroyuki; Hirabayashi Tetsuya; Kaneko Masayuki; Okuma Yasunobu; Murayama Toshihiko
Release of arachidonic acid induced by tumor necrosis factor-alpha in the presence of caspase inhibition: evidence for a cytosolic phospholipase A2alpha-independent pathway.
Biochemical pharmacology 2008;75(6):1358-69.
2007: Fujino Hiromichi; Chen Xiao-bo; Regan John W; Murayama Toshihiko
Indomethacin decreases EP2 prostanoid receptor expression in colon cancer cells.
Biochemical and biophysical research communications 2007;359(3):568-73.
2007: Sasaki Masumi; Nakamura Hiroyuki; Tsuchiya Shizuko; Horie Syunji; Kashiwayanagi Makoto; Saito Takeshi; Murayama Toshihiko
Quercetin-induced PC12 cell death accompanied by caspase-mediated DNA fragmentation.
Biological & pharmaceutical bulletin 2007;30(4):682-6.
2007: Taniguchi Tomoko; Shimizu Masaya; Nakamura Hiroyuki; Hirabayashi Tetsuya; Fujino Hiromichi; Saito Takeshi; Murayama Toshihiko
Vanadate-induced activation of cytosolic phospholipase A2alpha in L929 cells: Roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.
Biochemical pharmacology 2007;73(6):854-62.
2006: Takayama Hiromitsu; Misawa Kaori; Okada Naoki; Ishikawa Hayato; Kitajima Mariko; Hatori Yoshio; Murayama Toshihiko; Wongseripipatana Sumphan; Tashima Kimihito; Matsumoto Kenjiro; Horie Syunji
New procedure to mask the 2,3-pi bond of the indole nucleus and its application to the preparation of potent opioid receptor agonists with a Corynanthe skeleton.
Organic letters 2006;8(25):5705-8.
2006: Matsumoto Kenjiro; Hatori Yoshio; Murayama Toshihiko; Tashima Kimihito; Wongseripipatana Sumphan; Misawa Kaori; Kitajima Mariko; Takayama Hiromitsu; Horie Syunji
Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa.
European journal of pharmacology 2006;549(1-3):63-70.
2006: Taniguchi Tomoko; Shimizu Masaya; Nakamura Hiroyuki; Hirabayashi Tetsuya; Fujino Hiromichi; Murayama Toshihiko
Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2alpha.
European journal of pharmacology 2006;546(1-3):1-10.
2006: Akiyama Nobuteru; Nabemoto Maiko; Hatori Yoshio; Nakamura Hiroyuki; Hirabayashi Tetsuya; Fujino Hiromichi; Saito Takeshi; Murayama Toshihiko
Up-regulation of cytosolic phospholipase A2alpha expression by N,N-diethyldithiocarbamate in PC12 cells; involvement of reactive oxygen species and nitric oxide.
Toxicology and applied pharmacology 2006;215(2):218-27.
2006: Nakamura Hiroyuki; Hirabayashi Tetsuya; Shimizu Masaya; Murayama Toshihiko
Ceramide-1-phosphate activates cytosolic phospholipase A2alpha directly and by PKC pathway.
Biochemical pharmacology 2006;71(6):850-7.
2005: Matsumoto Kenjiro; Horie Syunji; Takayama Hiromitsu; Ishikawa Hayato; Aimi Norio; Ponglux Dhavadee; Murayama Toshihiko; Watanabe Kazuo
Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
Life sciences 2005;78(1):2-7.
2005: Takashiro Yuko; Nakamura Hiroyuki; Koide Yuuki; Nishida Atsushi; Murayama Toshihiko
Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells.
Biochemical pharmacology 2005;70(2):258-65.
2005: Akiyama Nobuteru; Shimma Naoko; Takashiro Yuko; Hatori Yoshio; Hirabayashi Tetsuya; Horie Syunji; Saito Takashi; Murayama Toshihiko
Decrease in cytosolic phospholipase A2alpha mRNA levels by reactive oxygen species via MAP kinase pathways in PC12 cells: effects of dopaminergic neurotoxins.
Cellular signalling 2005;17(5):597-604.
2005: Nabemoto Maiko; Ohsawa Keiko; Nakamura Hiroyuki; Hirabayashi Tetsuya; Saito Takeshi; Okuma Yasunobu; Nomura Yasuyuki; Murayama Toshihiko
Reversible activation of secretory phospholipase A2 by sulfhydryl reagents.
Archives of biochemistry and biophysics 2005;436(1):145-53.
2005: Minowa Sachie; Ishihara Satomi; Tsuchiya Shizuko; Horie Syunji; Murayama Toshihiko
Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain.
Brain research 2005;1039(1-2):75-83.
2005: Horie Syunji; Koyama Fumi; Takayama Hiromitsu; Ishikawa Hayato; Aimi Norio; Ponglux Dhavadee; Matsumoto Kenjiro; Murayama Toshihiko
Indole alkaloids of a Thai medicinal herb, Mitragyna speciosa, that has opioid agonistic effect in guinea-pig ileum.
Planta medica 2005;71(3):231-6.
2005: Horie Syunji; Tsurumaki Yuumi; Someya Akiyoshi; Hirabayashi Tetsuya; Saito Takeshi; Okuma Yasunobu; Nomura Yasuyuki; Murayama Toshihiko
Involvement of cyclooxygenase-dependent pathway in contraction of isolated ileum by urotensin II.
Peptides 2005;26(2):323-9.
2005: Kunieda Kana; Someya Akiyoshi; Horie Syunji; Ajioka Hirofusa; Murayama Toshihiko
Lafutidine-induced increase in intracellular ca(2+) concentrations in PC12 and endothelial cells.
Journal of pharmacological sciences 2005;97(1):67-74.
2004: Nakamura Hiroyuki; Takashiro Yuko; Hirabayashi Tetsuya; Horie Syunji; Koide Yuuki; Nishida Atsushi; Murayama Toshihiko
Effects of synthetic sphingosine-1-phosphate analogs on arachidonic acid metabolism and cell death.
Biochemical pharmacology 2004;68(11):2187-96.
2004: Someya Akiyoshi; Kunieda Kana; Akiyama Nobuteru; Hirabayashi Tetsuya; Horie Syunji; Murayama Toshihiko
Expression of vanilloid VR1 receptor in PC12 cells.
Neurochemistry international 2004;45(7):1005-10.
2004: Shimizu Masaya; Azuma Chihiro; Taniguchi Tomoko; Murayama Toshihiko
Expression of cytosolic phospholipase A2 alpha in murine C12 cells, a variant of L929 cells, induces arachidonic acid release in response to phorbol myristate acetate and Ca2+ ionophores, but not to tumor necrosis factor-alpha.
Journal of pharmacological sciences 2004;96(3):324-32.
2004: Hirabayashi Tetsuya; Murayama Toshihiko; Shimizu Takao
Regulatory mechanism and physiological role of cytosolic phospholipase A2.
Biological & pharmaceutical bulletin 2004;27(8):1168-73.
2004: Akiyama Nobuteru; Hatori Yoshio; Takashiro Yuko; Hirabayashi Tetsuya; Saito Takeshi; Murayama Toshihiko
Nerve growth factor-induced up-regulation of cytosolic phospholipase A2alpha level in rat PC12 cells.
Neuroscience letters 2004;365(3):218-22.
2004: Horie S; Yamamoto H; Michael G J; Uchida M; Belai A; Watanabe K; Priestley J V; Murayama T
Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats.
Scandinavian journal of gastroenterology 2004;39(4):303-12.
2004: Minowa Sachie; Tsuchiya Shizuko; Someya Akiyoshi; Horie Syunji; Murayama Toshihiko
Role of neuropeptide receptor systems in vanilloid VR1 receptor-mediated gastric acid secretion in rat brain.
European journal of pharmacology 2004;486(3):317-24.
2004: Shimamura Ken; Takashiro Yuko; Akiyama Nobuteru; Hirabayashi Tetsuya; Murayama Toshihiko
Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells.
European journal of pharmacology 2004;486(2):141-50.
2004: Nakamura Hiroyuki; Hirabayashi Testuya; Someya Akiyoshi; Shimizu Masaya; Murayama Toshihiko
Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine.
European journal of pharmacology 2004;484(1):9-17.
2004: Ogura Junko; Mitamura Mana; Someya Akiyoshi; Shimamura Ken; Takayama Hiromitsu; Aimi Norio; Horie Syunji; Murayama Toshihiko
Mesaconitine-induced relaxation in rat aorta: role of Na+/Ca2+ exchangers in endothelial cells.
European journal of pharmacology 2004;483(2-3):139-46.
2003: Shimma Naoko; Akiyama Nobuteru; Umezawa Michiko; Okuma Yasunobu; Nomura Yasuyuki; Saito Takeshi; Horie Syunji; Murayama Toshihiko
Possible role of interleukin-6 in PC12 cell death induced by MPP+ and tetrahydroisoquinoline.
Journal of pharmacological sciences 2003;93(4):471-7.
2003: Horie Syunji; Yasuda Satoko; Tsurumaki Yuumi; Someya Akiyoshi; Saito Takeshi; Okuma Yasunobu; Nomura Yasuyuki; Hirabayashi Tetsuya; Murayama Toshihiko
Contraction of isolated guinea-pig ileum by urotensin II via activation of ganglionic cholinergic neurons and acetylcholine release.
Neuropharmacology 2003;45(7):1019-27.
2003: Someya Akiyoshi; Horie Shunji; Yamamoto Hisashi; Murayama Toshihiko
Modifications of capsaicin-sensitive neurons in isolated guinea pig ileum by [6]-gingerol and lafutidine.
Journal of pharmacological sciences 2003;92(4):359-66.
2003: Minowa Sachie; Ishihara Satomi; Tsuchiya Shizuko; Horie Syunji; Watanabe Kazuo; Murayama Toshihiko
Involvement of glutamate and gamma-amino-butyric acid receptor systems on gastric acid secretion induced by activation of kappa-opioid receptors in the central nervous system in rats.
British journal of pharmacology 2003;138(6):1049-58.
2003: Nemoto Takanori; Shimma Naoko; Horie Syunji; Saito Takeshi; Okuma Yasunobu; Nomura Yasuyuki; Murayama Toshihiko
Involvement of the system L amino acid transporter on uptake of S-nitroso-L-cysteine, an endogenous S-nitrosothiol, in PC12 cells.
European journal of pharmacology 2003;458(1-2):17-24.
2002: Komasaka Midori; Horie Syunji; Watanabe Kazuo; Murayama Toshihiko
Antisecretory effect of somatostatin on gastric acid via inhibition of histamine release in isolated mouse stomach.
European journal of pharmacology 2002;452(2):235-43.
2002: Mitamura Mana; Boussery Koen; Horie Syunji; Murayama Toshihiko; Van de Voorde Johan
Vasorelaxing effect of mesaconitine, an alkaloid from Aconitum japonicum, on rat small gastric artery: possible involvement of endothelium-derived hyperpolarizing factor.
Japanese journal of pharmacology 2002;89(4):380-7.
2002: Someya Akiyoshi; Horie Syunji; Murayama Toshihiko
Arachidonic acid release and prostaglandin F(2alpha) formation induced by anandamide and capsaicin in PC12 cells.
European journal of pharmacology 2002;450(2):131-9.
2002: Ohsawa Keiko; Mori Asako; Horie Syunji; Saito Takeshi; Okuma Yasunobu; Nomura Yasuyuki; Murayama Toshihiko
Arachidonic acid release and prostaglandin F2alpha formation induced by phenylarsine oxide in PC12 cells: possible involvement of secretory phospholipase A2 activity.
Biochemical pharmacology 2002;64(1):117-24.
2002: Ishihara Satomi; Minowa Sachie; Tsuchiya Shizuko; Horie Syunji; Watanabe Kazuo; Murayama Toshihiko
Gastric acid secretion stimulated by centrally injected nociceptin in urethane-anesthetized rats.
European journal of pharmacology 2002;441(1-2):105-14.
2002: Takayama Hiromitsu; Ishikawa Hayato; Kurihara Mika; Kitajima Mariko; Aimi Norio; Ponglux Dhavadee; Koyama Fumi; Matsumoto Kenjiro; Moriyama Tomoyuki; Yamamoto Leonard T; Watanabe Kazuo; Murayama Toshihiko; Horie Syunji
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.
Journal of medicinal chemistry 2002;45(9):1949-56.
2002: Mitamura Mana; Horie Syunji; Sakaguchi Masaru; Someya Akiyoshi; Tsuchiya Shizuko; Van de Voorde Johan; Murayama Toshihiko; Watanabe Kazuo
Mesaconitine-induced relaxation in rat aorta: involvement of Ca2+ influx and nitric-oxide synthase in the endothelium.
European journal of pharmacology 2002;436(3):217-25.
2001: Yamamoto H; Horie S; Uchida M; Tsuchiya S; Murayama T; Watanabe K
Effects of vanilloid receptor agonists and antagonists on gastric antral ulcers in rats.
European journal of pharmacology 2001;432(2-3):203-10.
2001: Minowa S; Tsuchiya S; Horie S; Watanabe K; Murayama T
Stimulatory effect of centrally injected capsaicin, an agonist of vanilloid receptors, on gastric acid secretion in rats.
European journal of pharmacology 2001;428(3):349-56.
2001: Ishihara S; Tsuchiya S; Horie S; Murayama T; Watanabe K
Gastric acid secretion by central injection of dynorphin A-(1-17), an endogenous ligand of kappa-opioid receptor, in urethane-anesthetized rats.
Japanese journal of pharmacology 2001;87(1):14-20.
2001: Nemoto T; Horie S; Okuma Y; Nomura Y; Murayama T
Possible involvement of amino acid transporters on S-nitroso-cysteine-induced inhibition of arachidonic acid release in PC12 cells.
Neuroscience letters 2001;311(2):117-20.
2001: Pang S; Tsuchiya S; Horie S; Uchida M; Murayama T; Watanabe K
Enhancement of phenylephrine-induced contraction in the isolated rat aorta with endothelium by H2O-extract from an Oriental medicinal plant Leonuri herba.
Japanese journal of pharmacology 2001;86(2):215-22.
2001: Ishihara S; Tsuchiya S; Horie S; Murayama T; Watanabe K
Stimulatory effects of centrally injected kappa-opioid receptor agonists on gastric acid secretion in urethane-anesthetized rats.
European journal of pharmacology 2001;418(3):187-94.

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