FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Gillian Murphy

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Physiology

Enzyme Activation

Anatomy

Co-author Network

Publications

TOP 3
Jian Hua Qi; Jonathan Sears; Mariya Ali; Brent Bell; Alecia Cutler; Quteba Ebrahem; Vera Knauper; Gillian Murphy; Nicholas Prayson; Bela Anand-Apte
Tissue inhibitor of metalloproteinases-3 peptides inhibit angiogenesis and choroidal neovascularization in mice.
William R English; Pierre Corvol; Gillian Murphy
LPS activates ADAM9 dependent shedding of ACE from endothelial cells.
Pedro Correa de Sampaio; David Auslaender; Antonio Virgilio Failla; Davia Krubasik; Gillian Murphy; Jeremy N Skepper; William R English
A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Gillian Murphy (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Jian Hua Qi; Jonathan Sears; Mariya Ali; Brent Bell; Alecia Cutler; Quteba Ebrahem; Vera Knauper; Gillian Murphy; Nicholas Prayson; Bela Anand-Apte
Tissue inhibitor of metalloproteinases-3 peptides inhibit angiogenesis and choroidal neovascularization in mice.
PloS one 2013;8(3):e55667.
2012: William R English; Pierre Corvol; Gillian Murphy
LPS activates ADAM9 dependent shedding of ACE from endothelial cells.
Biochemical and biophysical research communications 2012;421(1):70-5.
2012: Pedro Correa de Sampaio; David Auslaender; Antonio Virgilio Failla; Davia Krubasik; Gillian Murphy; Jeremy N Skepper; William R English
A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis.
PloS one 2012;7(2):e30753.
2011: Christopher J Tape; Sofie H Willems; Sarah L Dombernowsky; Peter L Stanley; Marton Fogarasi; Willem Ouwehand; John McCafferty; Gillian Murphy
Cross-domain inhibition of TACE ectodomain.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(14):5578-83.
2011: Gillian Murphy
Tissue inhibitors of metalloproteinases.
Genome biology 2011;12(11):233.
2011: Gillian Murphy; Hideaki Nagase
Localizing matrix metalloproteinase activities in the pericellular environment.
The FEBS journal 2011;278(1):2-15.
2010: Patricia A Eisenach; Christian Roghi; Marton Fogarasi; Gillian Murphy; William R English
MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src.
Journal of cell science 2010;123(Pt 23):4182-93.
2010: Meng-Huee Lee; Susan Atkinson; Magdalini Rapti; Madeleine Handsley; Valerie Curry; Dylan Edwards; Gillian Murphy
The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment.
Cancer letters 2010;290(1):114-22.
2009: P J Lee; A Amos; L Robertson; B Fitzgerald; R Hoskin; Maggie Lilburn; E Weetch; Gillian Murphy
Adults with late diagnosed PKU and severe challenging behaviour: a randomised placebo-controlled trial of a phenylalanine-restricted diet.
Journal of neurology, neurosurgery, and psychiatry 2009;80(6):631-5.
2009: Gillian Murphy
Regulation of the proteolytic disintegrin metalloproteinases, the 'Sheddases'.
Seminars in cell & developmental biology 2009;20(2):138-45.
2009: Philippe Boutet; Sonia Agüera-González; Susan Atkinson; Caroline J Pennington; Dylan R Edwards; Gillian Murphy; Hugh Reyburn; Mar Valés-Gómez
Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):49-53.
2008: Gillian Murphy; Hideaki Nagase
Progress in matrix metalloproteinase research.
Molecular aspects of medicine 2008;29(5):290-308.
2008: Magdalini Rapti; Susan J Atkinson; Meng-Huee Lee; Andrew Trim; Marcia moss; Gillian Murphy
The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition.
The Biochemical journal 2008;411(2):433-9.
2008: Gillian Murphy; Hideaki Nagase
Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?
Nature clinical practice. Rheumatology 2008;4(3):128-35.
2008: Gillian Murphy; Aditya Murthy; Rama Khokha
Clipping, shedding and RIPping keep immunity on cue.
Trends in immunology 2008;29(2):75-82.
2007: Meng-Huee Lee; Susan Atkinson; Gillian Murphy
Identification of the extracellular matrix (ECM) binding motifs of tissue inhibitor of metalloproteinases (TIMP)-3 and effective transfer to TIMP-1.
The Journal of biological chemistry 2007;282(9):6887-98.
2007: Rosalind M Hembry; Susan J Atkinson; Gillian Murphy
Assessment of gelatinase expression and activity in articular cartilage.
Methods in molecular medicine 2007;135():227-38.
2006: Magdalini Rapti; Vera Knaüper; Gillian Murphy; Richard A Williamson
Characterization of the AB loop region of TIMP-2. Involvement in pro-MMP-2 activation.
The Journal of biological chemistry 2006;281(33):23386-94.
2006: Susan J Atkinson; Christian Roghi; Gillian Murphy
MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells.
The Biochemical journal 2006;398(1):15-22.
2006: Vincent Chabottaux; Nor Eddine SOUNNI; Caroline J Pennington; William R English; Frédéric van den Brûle; Silvia Blacher; Christine Gilles; Carine Munaut; Erik Maquoi; Carlos Lopez-Otin; Gillian Murphy; Dylan R Edwards; Jean-Michel Foidart; Agnès Noël
Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases.
Cancer research 2006;66(10):5165-72.
2006: Jane L English; Zamaneh Kassiri; Ilpo Koskivirta; Susan J Atkinson; Marco Di Grappa; Paul D Soloway; Hideaki Nagase; Eero Vuorio; Gillian Murphy; Rama Khokha
Individual Timp deficiencies differentially impact pro-MMP-2 activation.
The Journal of biological chemistry 2006;281(15):10337-46.
2006: P C M van de Kerkhof; Knud Kragballe; Joar Austad; John Berth-Jones; Frédéric Cambazard; Michel de la Brassinne; Anders Ljungberg; Gillian Murphy; Kim Papp; Gottfried Wozel
Psoriasis: severity assessment in clinical practice. Conclusions from workshop discussions and a prospective multicentre survey of psoriasis severity.
European journal of dermatology : EJD 2006;16(2):167-71.
2006: M J Wallard; C J Pennington; Abhi Veerakumarasivam; Glyn J Burtt; Ian Mills; A Warren; H Y Leung; Gillian Murphy; D R Edwards; David E Neal; J D Kelly
Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma.
British journal of cancer 2006;94(4):569-77.
2005: Gillian Murphy; Meng-Huee Lee
What are the roles of metalloproteinases in cartilage and bone damage?
Annals of the rheumatic diseases 2005;64 Suppl 4():iv44-7.
2005: Riccardo E Nisato; Ghamartaj Hosseini; Christian Sirrenberg; Georgina S Butler; Tom Crabbe; Andrew J P Docherty; Matthias Wiesner; Gillian Murphy; Christopher M Overall; Simon L Goodman; Michael S Pepper
Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical.
Cancer research 2005;65(20):9377-87.
2005: Robert J R Singh; Justin C Mason; Elaine A Lidington; Dylan R Edwards; Robert K Nuttall; Rama Khokha; Vera Knauper; Gillian Murphy; Jelena Gavrilovic
Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3.
Cardiovascular research 2005;67(1):39-49.
2005: Surinder M Soond; Bethany Everson; David W H Riches; Gillian Murphy
ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking.
Journal of cell science 2005;118(Pt 11):2371-80.
2005: Meng-Huee Lee; Magdalini Rapti; Gillian Murphy
Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: fine-tuning TIMP-4 for optimal inhibition of tumor necrosis factor-{alpha}-converting enzyme.
The Journal of biological chemistry 2005;280(16):15967-75.
2004: Meng-Huee Lee; Magdalini Rapti; Gillian Murphy
Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme.
The Journal of biological chemistry 2004;279(43):45121-9.
2004: Meng-Huee Lee; Gillian Murphy
Matrix metalloproteinases at a glance.
Journal of cell science 2004;117(Pt 18):4015-6.
2004: Stephen T Holgate; Donna E Davies; Steuart Rorke; Julie A Cakebread; Gillian Murphy; Robert M Powell; John W Holloway
ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma.
Clinical reviews in allergy & immunology 2004;27(1):23-34.
2004: Susan J Atkinson; Jane L English; Nick Holway; Gillian Murphy
Cellular cholesterol regulates MT1 MMP dependent activation of MMP 2 via MEK-1 in HT1080 fibrosarcoma cells.
FEBS letters 2004;566(1-3):65-70.
2004: Meng-Huee Lee; Magdalini Rapti; Vera Knaüper; Gillian Murphy
Threonine 98, the pivotal residue of tissue inhibitor of metalloproteinases (TIMP)-1 in metalloproteinase recognition.
The Journal of biological chemistry 2004;279(17):17562-9.
2004: Nor Eddine SOUNNI; Christian Roghi; Vincent Chabottaux; Mathias Janssen; Carine Munaut; Erik Maquoi; Beatriz G Galvez; Christine Gilles; Francis Frankenne; Gillian Murphy; Jean-Michel Foidart; Agnès Noel
Up-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases.
The Journal of biological chemistry 2004;279(14):13564-74.
2004: Fred H Rasmussen; Nolan Yeung; Laura Kiefer; Gillian Murphy; Carlos Lopez-Otin; Michael P. Vitek; Marcia moss
Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases.
Biochemistry 2004;43(11):2987-95.
2003: Meng-Huee Lee; Magdalini Rapti; Gillian Murphy
Unveiling the surface epitopes that render tissue inhibitor of metalloproteinase-1 inactive against membrane type 1-matrix metalloproteinase.
The Journal of biological chemistry 2003;278(41):40224-30.
2003: Albert Remacle; Gillian Murphy; Christian Roghi
Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surface.
Journal of cell science 2003;116(Pt 19):3905-16.
2003: Steven J Wall; Mike J Sampson; N Levell; Gillian Murphy
Elevated matrix metalloproteinase-2 and -3 production from human diabetic dermal fibroblasts.
The British journal of dermatology 2003;149(1):13-6.
2003: Joanna R Worley; Philip B Thompkins; Meng H Lee; Mike Hutton; Paul Soloway; Dylan R Edwards; Gillian Murphy; Vera Knäuper
Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP).
The Biochemical journal 2003;372(Pt 3):799-809.
2003: S T Holgate; Donna E Davies; Gillian Murphy; Robert M Powell; John W Holloway
ADAM 33: just another asthma gene or a breakthrough in understanding the origins of bronchial hyperresponsiveness?
Thorax 2003;58(6):466-9.
2003: Meng-Huee Lee; Philippa Dodds; Vandana Verma; Klaus Maskos; Vera Knäuper; Gillian Murphy
Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-alpha converting enzyme.
The Biochemical journal 2003;371(Pt 2):369-76.
2003: Gillian Murphy; Vera Knäuper; Meng-Huee Lee; Augustin Amour; Joanna R Worley; Mike Hutton; Susan Atkinson; Magdalini Rapti; Richard Williamson
Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis: the specificity is in the detail.
Biochemical Society symposium 2003;(70):65-80.
2002: Vera Knäuper; Louise Bailey; Joanna R Worley; Paul Soloway; Margaret L Patterson; Gillian Murphy
Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13.
FEBS letters 2002;532(1-2):127-30.
2002: Meng-Huee Lee; Klaus Maskos; Vera Knäuper; Philippa Dodds; Gillian Murphy
Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)-3 using TIMP-1 as the scaffold: a new frontier in TIMP engineering.
Protein science : a publication of the Protein Society 2002;11(10):2493-503.
2002: Marc A Lafleur; Madeleine M Handsley; Vera Knäuper; Gillian Murphy; Dylan R Edwards
Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs).
Journal of cell science 2002;115(Pt 17):3427-38.
2002: Augustin Amour; C Graham Knight; William R English; Ailsa Webster; Patrick M Slocombe; Vera Knäuper; Andrew J P Docherty; J David Becherer; Carl P Blobel; Gillian Murphy
The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs.
FEBS letters 2002;524(1-3):154-8.
2002: Steven J Wall; Damon Bevan; David W Thomas; Keith G Harding; Dylan R Edwards; Gillian Murphy
Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse.
The Journal of investigative dermatology 2002;119(1):91-8.
2002: Meng-Huee Lee; Vandana Verma; Klaus Maskos; J David Becherer; Vera Knäuper; Philippa Dodds; Augustin Amour; Gillian Murphy
The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3.
FEBS letters 2002;520(1-3):102-6.
2002: Meng-Huee Lee; Vandana Verma; Klaus Maskos; Deepa Nath; Vera Knäuper; Philippa Dodds; Augustin Amour; Gillian Murphy
Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme.
The Biochemical journal 2002;364(Pt 1):227-34.
2002: Juan Carlos Rodríguez-Manzaneque; Jennifer Westling; Shelley N-M Thai; Alfonso Luque; Vera Knauper; Gillian Murphy; John D Sandy; M Luisa Iruela-Arispe
ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors.
Biochemical and biophysical research communications 2002;293(1):501-8.
2002: Mark Bond; Gillian Murphy; Martin R Bennett; Andrew C Newby; Andrew H Baker
Tissue inhibitor of metalloproteinase-3 induces a Fas-associated death domain-dependent type II apoptotic pathway.
The Journal of biological chemistry 2002;277(16):13787-95.
2002: Louise Bailey; Dirk Wienke; Matthew Howard; Vera Knäuper; Clare M Isacke; Gillian Murphy
Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor.
The Biochemical journal 2002;363(Pt 1):67-72.
2002: Zaruhi Poghosyan; Stephen M Robbins; Miles D Houslay; Ailsa Webster; Gillian Murphy; Dylan R Edwards
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.
The Journal of biological chemistry 2002;277(7):4999-5007.
2002: Gillian Murphy; Vera Knäuper; Susan Atkinson; George Butler; William R English; Mike Hutton; Jan Stracke; Ian Clark
Matrix metalloproteinases in arthritic disease.
Arthritis research 2002;4 Suppl 3():S39-49.
2002: Karen M Yeow; Narendra S Kishnani; Mike Hutton; Susan P Hawkes; Gillian Murphy; Dylan R Edwards
Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix.
Matrix biology : journal of the International Society for Matrix Biology 2002;21(1):75-88.
2001: William R English; B Holtz; G Vogt; Vera Knäuper; Gillian Murphy
Characterization of the role of the "MT-loop": an eight-amino acid insertion specific to progelatinase A (MMP2) activating membrane-type matrix metalloproteinases.
The Journal of biological chemistry 2001;276(45):42018-26.
2001: Vincent Ellis; Gillian Murphy
Cellular strategies for proteolytic targeting during migration and invasion.
FEBS letters 2001;506(1):1-5.
2001: Richard A Williamson; Mike Hutton; G Vogt; Magdalini Rapti; Vera Knäuper; Mark D Carr; Gillian Murphy
Tyrosine 36 plays a critical role in the interaction of the AB loop of tissue inhibitor of metalloproteinases-2 with matrix metalloproteinase-14.
The Journal of biological chemistry 2001;276(35):32966-70.
2001: Margaret L Patterson; Susan J Atkinson; Vera Knäuper; Gillian Murphy
Specific collagenolysis by gelatinase A, MMP-2, is determined by the hemopexin domain and not the fibronectin-like domain.
FEBS letters 2001;503(2-3):158-62.
2001: Marc A Lafleur; M D Hollenberg; Susan J Atkinson; Vera Knäuper; Gillian Murphy; Dylan R Edwards
Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species.
The Biochemical journal 2001;357(Pt 1):107-15.
2001: Rosalind M Hembry; J Dyce; I M K Driesang; Ernst B Hunziker; Amanda J Fosang; J A Tyler; Gillian Murphy
Immunolocalization of matrix metalloproteinases in partial-thickness defects in pig articular cartilage. A preliminary report.
The Journal of bone and joint surgery. American volume 2001;83-A(6):826-38.
2001: Marc A Lafleur; Peter A Forsyth; Susan J Atkinson; Gillian Murphy; Dylan R Edwards
Perivascular cells regulate endothelial membrane type-1 matrix metalloproteinase activity.
Biochemical and biophysical research communications 2001;282(2):463-73.
2001: Milagros Balbín; Antonio Fueyo; Vera Knäuper; José M López; Javier Alvarez; Luis M Sánchez; Víctor Quesada; J Bordallo; Gillian Murphy; Carlos López-Otín
Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.
The Journal of biological chemistry 2001;276(13):10253-62.
2001: Susan J Atkinson; Margaret L Patterson; Michael J Butler; Gillian Murphy
Membrane type 1 matrix metalloproteinase and gelatinase A synergistically degrade type 1 collagen in a cell model.
FEBS letters 2001;491(3):222-6.
2001: Vera Knäuper; Margaret L Patterson; F X Gomis-Rüth; B Smith; A Lyons; Andrew J P Docherty; Gillian Murphy
The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity.
European journal of biochemistry / FEBS 2001;268(6):1888-96.
2001: Deepa Nath; N J Williamson; R Jarvis; Gillian Murphy
Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase.
Journal of cell science 2001;114(Pt 6):1213-20.
2001: William R English; Gloria Velasco; Jan Stracke; Vera Knäuper; Gillian Murphy
Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25).
FEBS letters 2001;491(1-2):137-42.
2001: Meng-Huee Lee; Vera Knäuper; J David Becherer; Gillian Murphy
Full-length and N-TIMP-3 display equal inhibitory activities toward TNF-alpha convertase.
Biochemical and biophysical research communications 2001;280(3):945-50.
2001: Vera Knäuper; Gillian Murphy
Methods for studying activation of matrix metalloproteinases.
Methods in molecular biology (Clifton, N.J.) 2001;151():377-87.
2000: Mark Bond; Gillian Murphy; Martin R Bennett; Augustin Amour; Vera Knauper; Andrew C Newby; Andrew H Baker
Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus. Metalloproteinase inhibition is associated with proapoptotic activity.
The Journal of biological chemistry 2000;275(52):41358-63.
2000: Jan Stracke; Amanda J Fosang; Karena Last; FA Mercuri; Alberto Pendas; Elena Llano; R Perris; Paul Dicesare; Gillian Murphy; Vera Knäuper
Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).
FEBS letters 2000;478(1-2):52-6.
2000: Deepa Nath; Patrick M Slocombe; Ailsa Webster; PE Stephens; Andrew J P Docherty; Gillian Murphy
Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1 )integrin, leading to a marked induction of fibroblast cell motility.
Journal of cell science 2000;113 ( Pt 12)():2319-28.
2000: E Stringa; Vera Knäuper; Gillian Murphy; Jelena Gavrilovic
Collagen degradation and platelet-derived growth factor stimulate the migration of vascular smooth muscle cells.
Journal of cell science 2000;113 ( Pt 11)():2055-64.
2000: Augustin Amour; C Graham Knight; Ailsa Webster; Patrick M Slocombe; PE Stephens; Vera Knäuper; Andrew J P Docherty; Gillian Murphy
The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3.
FEBS letters 2000;473(3):275-9.
2000: Jan Stracke; Mike Hutton; M Stewart; Alberto Pendas; B Smith; C López-Otin; Gillian Murphy; Vera Knäuper
Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme.
The Journal of biological chemistry 2000;275(20):14809-16.
2000: William R English; Xose S Puente; José M P Freije; Vera Knauper; Augustin Amour; A Merryweather; Carlos Lopez-Otin; Gillian Murphy
Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2.
The Journal of biological chemistry 2000;275(19):14046-55.
2000: Erik Maquoi; Francis Frankenne; Eugenia N Baramova; Carine Munaut; Nor Eddine SOUNNI; Albert G Remacle; Agnès Noël; Gillian Murphy; Jean-Michel Foidart
Membrane type 1 matrix metalloproteinase-associated degradation of tissue inhibitor of metalloproteinase 2 in human tumor cell lines.
The Journal of biological chemistry 2000;275(15):11368-78.
2000: G Dew; Gillian Murphy; Heather Stanton; Rüdiger Vallon; Peter Angel; John J Reynolds; Rosalind M Hembry
Localisation of matrix metalloproteinases and TIMP-2 in resorbing mouse bone.
Cell and tissue research 2000;299(3):385-94.
1999: Jill M Maidment; D Moore; G P Murphy; Gillian Murphy; Ian Clark
Matrix metalloproteinase homologues from Arabidopsis thaliana. Expression and activity.
The Journal of biological chemistry 1999;274(49):34706-10.
1999: J J Breckon; Stelios Papaioannou; L W Kon; Anthony Tumber; Rosalind M Hembry; Gillian Murphy; John J Reynolds; Murray C Meikle
Stromelysin (MMP-3) synthesis is up-regulated in estrogen-deficient mouse osteoblasts in vivo and in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(11):1880-90.
1999: Gillian Murphy; Jelena Gavrilovic
Proteolysis and cell migration: creating a path?
Current opinion in cell biology 1999;11(5):614-21.
1999: Georgina S Butler; Mike Hutton; B A Wattam; Richard A Williamson; Vera Knäuper; F Willenbrock; Gillian Murphy
The specificity of TIMP-2 for matrix metalloproteinases can be modified by single amino acid mutations.
The Journal of biological chemistry 1999;274(29):20391-6.
1999: Augustin Amour; Mike Hutton; Vera Knäuper; Patrick M Slocombe; Ailsa Webster; M Butler; C Graham Knight; B J Smith; Andrew J P Docherty; Gillian Murphy
Inhibition of the metalloproteinase domain of mouse TACE.
Annals of the New York Academy of Sciences 1999;878():728-31.
1999: Mike Hutton; Georgina S Butler; B A Wattam; F Willenbrock; Richard A Williamson; Gillian Murphy
Analysis of the interaction of TIMP-2 and MMPs: engineering the changes.
Annals of the New York Academy of Sciences 1999;878():524-7.
1999: Gillian Murphy; Vera Knäuper; S Cowell; Rosalind M Hembry; Heather Stanton; George Butler; José M P Freije; Alberto Pendas; Carlos López-Otín
Evaluation of some newer matrix metalloproteinases.
Annals of the New York Academy of Sciences 1999;878():25-39.
1999: Elena Llano; Alberto Pendas; JP Freije; A Nakano; Vera Knäuper; Gillian Murphy; C López-Otin
Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors.
Cancer research 1999;59(11):2570-6.
1999: Georgina S Butler; S S Apte; F Willenbrock; Gillian Murphy
Human tissue inhibitor of metalloproteinases 3 interacts with both the N- and C-terminal domains of gelatinases A and B. Regulation by polyanions.
The Journal of biological chemistry 1999;274(16):10846-51.
1999: Andrew H Baker; Sarah George; AB Zaltsman; Gillian Murphy; Andrew C Newby
Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3.
British journal of cancer 1999;79(9-10):1347-55.
1999: Gloria Velasco; Alberto Pendas; Antonio Fueyo; Vera Knäuper; Gillian Murphy; Carlos López-Otín
Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members.
The Journal of biological chemistry 1999;274(8):4570-6.
1999: Deepa Nath; Patrick M Slocombe; PE Stephens; A Warn; G R Hutchinson; K M Yamada; Andrew J P Docherty; Gillian Murphy
Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells.
Journal of cell science 1999;112 ( Pt 4)():579-87.
1999: Gillian Murphy; Heather Stanton; S Cowell; George Butler; Vera Knäuper; Susan Atkinson; Jelena Gavrilovic
Mechanisms for pro matrix metalloproteinase activation.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1999;107(1):38-44.
1998: Augustin Amour; Patrick M Slocombe; Ailsa Webster; M Butler; C Graham Knight; B J Smith; PE Stephens; Chris Shelley; Mike Hutton; Vera Knäuper; Andrew J P Docherty; Gillian Murphy
TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3.
FEBS letters 1998;435(1):39-44.
1998: Milagros Balbín; Antonio Fueyo; Vera Knäuper; Alberto Pendas; José M López; MG Jiménez; Gillian Murphy; Carlos López-Otín
Collagenase 2 (MMP-8) expression in murine tissue-remodeling processes. Analysis of its potential role in postpartum involution of the uterus.
The Journal of biological chemistry 1998;273(37):23959-68.
1998: Heather Stanton; Jelena Gavrilovic; Susan J Atkinson; Marie-Pia d'Ortho; K M Yamada; L Zardi; Gillian Murphy
The activation of ProMMP-2 (gelatinase A) by HT1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP-14) to a 45 kDa form.
Journal of cell science 1998;111 ( Pt 18)():2789-98.
1998: Mike Hutton; F Willenbrock; Keith Brocklehurst; Gillian Murphy
Kinetic analysis of the mechanism of interaction of full-length TIMP-2 and gelatinase A: evidence for the existence of a low-affinity intermediate.
Biochemistry 1998;37(28):10094-8.
1998: S Cowell; Vera Knäuper; M L Stewart; Marie-Pia d'Ortho; Heather Stanton; Rosalind M Hembry; Carlos López-Otín; John J Reynolds; Gillian Murphy
Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3.
The Biochemical journal 1998;331 ( Pt 2)():453-8.
1998: Anthea J Messent; Danny S Tuckwell; Vera Knäuper; Martin J Humphries; Gillian Murphy; Jelena Gavrilovic
Effects of collagenase-cleavage of type I collagen on alpha2beta1 integrin-mediated cell adhesion.
Journal of cell science 1998;111 ( Pt 8)():1127-35.
1998: Erik Maquoi; Agnès Noël; Francis Frankenne; H Angliker; Gillian Murphy; Jean-Michel Foidart
Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor.
FEBS letters 1998;424(3):262-6.
1998: Marie-Pia d'Ortho; Heather Stanton; M Butler; Susan J Atkinson; Gillian Murphy; Rosalind M Hembry
MT1-MMP on the cell surface causes focal degradation of gelatin films.
FEBS letters 1998;421(2):159-64.
1998: Georgina S Butler; Michael J Butler; Susan J Atkinson; H Will; T Tamura; S Schade van Westrum; Tom Crabbe; J Clements; Marie-Pia d'Ortho; Gillian Murphy
The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study.
The Journal of biological chemistry 1998;273(2):871-80.
1998: Mark Cockett; Gillian Murphy; M L Birch; J P O'Connell; Tom Crabbe; AT Millican; I R Hart; Andy J Docherty
Matrix metalloproteinases and metastatic cancer.
Biochemical Society symposium 1998;63():295-313.
1997: Marie-Pia d'Ortho; H Will; Susan Atkinson; George Butler; Anthea J Messent; Jelena Gavrilovic; B Smith; R Timpl; L Zardi; Gillian Murphy
Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases.
European journal of biochemistry / FEBS 1997;250(3):751-7.
1997: Elena Llano; Alberto Pendas; Vera Knäuper; T Sorsa; Tuula Salo; E Salido; Gillian Murphy; J P Simmer; J D Bartlett; Carlos López-Otín
Identification and structural and functional characterization of human enamelysin (MMP-20).
Biochemistry 1997;36(49):15101-8.
1997: Vera Knäuper; B Smith; C López-Otin; Gillian Murphy
Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13).
European journal of biochemistry / FEBS 1997;248(2):369-73.
1997: Vera Knäuper; S Cowell; B Smith; C López-Otin; M O'Shea; H Morris; L Zardi; Gillian Murphy
The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction.
The Journal of biological chemistry 1997;272(12):7608-16.
1997: Vera Knäuper; Andrew J P Docherty; B Smith; Harald Tschesche; Gillian Murphy
Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP-8) to stability and collagenolytic activity by alanine scanning mutagenesis.
FEBS letters 1997;405(1):60-4.
1997: Gillian Murphy; V Knäuper
Relating matrix metalloproteinase structure to function: why the "hemopexin" domain?
Matrix biology : journal of the International Society for Matrix Biology 1997;15(8-9):511-8.
1997: Georgina S Butler; H Will; Susan J Atkinson; Gillian Murphy
Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases.
European journal of biochemistry / FEBS 1997;244(2):653-7.
1997: Alberto Pendas; Vera Knäuper; Xose S Puente; Elena Llano; M G Mattei; S Apte; Gillian Murphy; Carlos López-Otín
Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution.
The Journal of biological chemistry 1997;272(7):4281-6.
1996: F X Gomis-Rüth; U Gohlke; M Betz; V Knäuper; Gillian Murphy; C López-Otín; Wolfram Bode
The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain.
Journal of molecular biology 1996;264(3):556-66.
1996: J A Eble; A Ries; A Lichy; Karlheinz Mann; Heather Stanton; Jelena Gavrilovic; Gillian Murphy; K Kühn
The recognition sites of the integrins alpha1beta1 and alpha2beta1 within collagen IV are protected against gelatinase A attack in the native protein.
The Journal of biological chemistry 1996;271(48):30964-70.
1996: Richard A Williamson; D Natalia; C Gee; Gillian Murphy; Mark D Carr; Robert B Freedman
Chemically and conformationally authentic active domain of human tissue inhibitor of metalloproteinases-2 refolded from bacterial inclusion bodies.
European journal of biochemistry / FEBS 1996;241(2):476-83.
1996: Takako Sasaki; Karlheinz Mann; Gillian Murphy; Mon-Li Chu; Rupert Timpl
Different susceptibilities of fibulin-1 and fibulin-2 to cleavage by matrix metalloproteinases and other tissue proteases.
European journal of biochemistry / FEBS 1996;240(2):427-34.
1996: H Will; Susan J Atkinson; Georgina S Butler; B Smith; Gillian Murphy
The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3.
The Journal of biological chemistry 1996;271(29):17119-23.
1996: Vera Knäuper; H Will; C López-Otin; B Smith; Susan J Atkinson; Heather Stanton; Rosalind M Hembry; Gillian Murphy
Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme.
The Journal of biological chemistry 1996;271(29):17124-31.
1996: Vera Knäuper; C López-Otin; B Smith; G Knight; Gillian Murphy
Biochemical characterization of human collagenase-3.
The Journal of biological chemistry 1996;271(3):1544-50.
1996: U Gohlke; F X Gomis-Rüth; T Crabbe; Gillian Murphy; Andrew J P Docherty; Wolfram Bode
The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function.
FEBS letters 1996;378(2):126-30.
1995: Susan J Atkinson; T Crabbe; S Cowell; R V Ward; M J Butler; H Sato; Motoharu Seiki; John J Reynolds; Gillian Murphy
Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes.
The Journal of biological chemistry 1995;270(51):30479-85.
1995: F Willenbrock; C G Knight; Gillian Murphy; Ian R Phillips; Keith Brocklehurst
Evidence for the importance of weakly bound water for matrix metalloproteinase activity.
Biochemistry 1995;34(37):12012-8.
1995: J A Allan; Andrew J P Docherty; P J Barker; N S Huskisson; John J Reynolds; Gillian Murphy
Binding of gelatinases A and B to type-I collagen and other matrix components.
The Biochemical journal 1995;309 ( Pt 1)():299-306.
1995: F Willenbrock; Gillian Murphy; Ian R Phillips; Keith Brocklehurst
The second zinc atom in the matrix metalloproteinase catalytic domain is absent in the full-length enzymes: a possible role for the C-terminal domain.
FEBS letters 1995;358(2):189-92.
1995: Gillian Murphy; F Willenbrock
Tissue inhibitors of matrix metalloendopeptidases.
Methods in enzymology 1995;248():496-510.
1995: Gillian Murphy; T Crabbe
Gelatinases A and B.
Methods in enzymology 1995;248():470-84.
1994: F Willenbrock; Gillian Murphy
Structure-function relationships in the tissue inhibitors of metalloproteinases.
American journal of respiratory and critical care medicine 1994;150(6 Pt 2):S165-70.
1994: R V Ward; Susan J Atkinson; John J Reynolds; Gillian Murphy
Cell surface-mediated activation of progelatinase A: demonstration of the involvement of the C-terminal domain of progelatinase A in cell surface binding and activation of progelatinase A by primary fibroblasts.
The Biochemical journal 1994;304 ( Pt 1)():263-9.
1994: Peter A Hill; Gillian Murphy; Andrew J P Docherty; Rosalind M Hembry; T A Millican; John J Reynolds; Murray C Meikle
The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts.
Journal of cell science 1994;107 ( Pt 11)():3055-64.
1994: Richard A Williamson; G Martorell; Mark D Carr; Gillian Murphy; A J Docherty; Robert B Freedman; James Feeney
Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family.
Biochemistry 1994;33(39):11745-59.
1994: V Knäuper; Gillian Murphy; H Tschesche
Neutrophil procollagenase can be activated by stromelysin-2.
Annals of the New York Academy of Sciences 1994;732():367-8.
1994: J A Allan; Andrew J P Docherty; Gillian Murphy
The binding of gelatinases A and B to type I collagen yields both high and low affinity sites.
Annals of the New York Academy of Sciences 1994;732():365-6.
1994: Gillian Murphy; F Willenbrock; T Crabbe; M O'Shea; R Ward; Susan Atkinson; J O'Connell; Andrew J P Docherty
Regulation of matrix metalloproteinase activity.
Annals of the New York Academy of Sciences 1994;732():31-41.
1994: Richard A Williamson; H Bartels; Gillian Murphy; Robert B Freedman
Folding and stability of the active N-terminal domain of tissue inhibitor of metalloproteinases-1 and -2.
Protein engineering 1994;7(8):1035-40.
1994: T Crabbe; Stanley Zucker; Mark Cockett; F Willenbrock; S Tickle; J P O'Connell; J M Scothern; Gillian Murphy; Andrew J P Docherty
Mutation of the active site glutamic acid of human gelatinase A: effects on latency, catalysis, and the binding of tissue inhibitor of metalloproteinases-1.
Biochemistry 1994;33(21):6684-90.
1994: J P O'Connell; F Willenbrock; Andrew J P Docherty; D Eaton; Gillian Murphy
Analysis of the role of the COOH-terminal domain in the activation, proteolytic activity, and tissue inhibitor of metalloproteinase interactions of gelatinase B.
The Journal of biological chemistry 1994;269(21):14967-73.
1994: Gillian Murphy; Q Nguyen; Mark Cockett; Susan J Atkinson; J A Allan; C G Knight; F Willenbrock; Andrew J P Docherty
Assessment of the role of the fibronectin-like domain of gelatinase A by analysis of a deletion mutant.
The Journal of biological chemistry 1994;269(9):6632-6.
1994: Z Zhang; Paul Winyard; K Chidwick; Gillian Murphy; M Wardell; R W Carrell; David R Blake
Proteolysis of human native and oxidised alpha 1-proteinase inhibitor by matrilysin and stromelysin.
Biochimica et biophysica acta 1994;1199(2):224-8.
1994: Q Nguyen; F Willenbrock; Mark Cockett; M O'Shea; Andrew J P Docherty; Gillian Murphy
Different domain interactions are involved in the binding of tissue inhibitors of metalloproteinases to stromelysin-1 and gelatinase A.
Biochemistry 1994;33(8):2089-95.
1993: S P Tolley; Gideon J Davies; M O'Shea; Mark Cockett; Andrew J P Docherty; Gillian Murphy
Crystallization and preliminary X-ray analysis of nonglycosylated tissue inhibitor of metalloproteinases-1, N30QN78Q TIMP-1.
Proteins 1993;17(4):435-7.
1993: Ulrike Mayer; Karlheinz Mann; Rupert Timpl; Gillian Murphy
Sites of nidogen cleavage by proteases involved in tissue homeostasis and remodelling.
European journal of biochemistry / FEBS 1993;217(3):877-84.
1993: Rosalind M Hembry; M R Bagga; Gillian Murphy; B Henderson; John J Reynolds
Rabbit models of arthritis: immunolocalization of matrix metalloproteinases and tissue inhibitor of metalloproteinase in synovium and cartilage.
The American journal of pathology 1993;143(2):628-42.
1993: Gillian Murphy; J P Segain; M O'Shea; Mark Cockett; C Ioannou; Olivier Lefebvre; Pierre Chambon; P Basset
The 28-kDa N-terminal domain of mouse stromelysin-3 has the general properties of a weak metalloproteinase.
The Journal of biological chemistry 1993;268(21):15435-41.
1993: Richard A Williamson; B J Smith; S Angal; Gillian Murphy; Robert B Freedman
Structural analysis of tissue inhibitor of metalloproteinases-1 (TIMP-1) by tryptic peptide mapping.
Biochimica et biophysica acta 1993;1164(1):8-16.
1993: F Willenbrock; T Crabbe; Patrick M Slocombe; C W Sutton; Andrew J P Docherty; Mark Cockett; M O'Shea; Keith Brocklehurst; Ian R Phillips; Gillian Murphy
The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A.
Biochemistry 1993;32(16):4330-7.
1993: S Tolley; Gillian Murphy; M O'Shea; R Ward; Andrew J P Docherty; Mark Cockett; A Rawas; G Davies
Crystallization and preliminary X-ray analysis of a truncated tissue metalloproteinase inhibitor delta 128-194 TIMP-2.
Journal of molecular biology 1993;229(4):1163-4.
1992: Gillian Murphy; Susan Atkinson; R Ward; Jelena Gavrilovic; J J Reynolds
The role of plasminogen activators in the regulation of connective tissue metalloproteinases.
Annals of the New York Academy of Sciences 1992;667():1-12.
1992: Susan J Atkinson; R V Ward; John J Reynolds; Gillian Murphy
Cell-mediated degradation of type IV collagen and gelatin films is dependent on the activation of matrix metalloproteinases.
The Biochemical journal 1992;288 ( Pt 2)():605-11.
1992: M O'Shea; F Willenbrock; R A Williamson; Mark Cockett; R B Freedman; John J Reynolds; Andrew J P Docherty; Gillian Murphy
Site-directed mutations that alter the inhibitory activity of the tissue inhibitor of metalloproteinases-1: importance of the N-terminal region between cysteine 3 and cysteine 13.
Biochemistry 1992;31(42):10146-52.
1992: T Crabbe; F Willenbrock; D Eaton; P Hynds; A F Carne; Gillian Murphy; Andrew J P Docherty
Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases.
Biochemistry 1992;31(36):8500-7.
1992: Gillian Murphy; Andrew J P Docherty
The matrix metalloproteinases and their inhibitors.
American journal of respiratory cell and molecular biology 1992;7(2):120-5.
1992: Andrew J P Docherty; J O'Connell; T Crabbe; S Angal; Gillian Murphy
The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases.
Trends in biotechnology 1992;10(6):200-7.
1992: Gillian Murphy; J A Allan; F Willenbrock; Mark Cockett; J P O'Connell; Andrew J P Docherty
The role of the C-terminal domain in collagenase and stromelysin specificity.
The Journal of biological chemistry 1992;267(14):9612-8.
1992: Gillian Murphy; F Willenbrock; R V Ward; Mark Cockett; D Eaton; Andrew J P Docherty
The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases.
The Biochemical journal 1992;283 ( Pt 3)():637-41.
1992: C G Knight; F Willenbrock; Gillian Murphy
A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases.
FEBS letters 1992;296(3):263-6.
1992: Gillian Murphy; Rosalind M Hembry
Proteinases in rheumatoid arthritis.
The Journal of rheumatology. Supplement 1992;32():61-4.
1992: Gillian Murphy
Dissociation of tissue inhibitor of metalloproteinases (TIMP) from enzyme complexes yields fully active inhibitor.
Matrix (Stuttgart, Germany). Supplement 1992;1():323-4.
1992: Gillian Murphy; R Ward; Jelena Gavrilovic; Susan Atkinson
Physiological mechanisms for metalloproteinase activation.
Matrix (Stuttgart, Germany). Supplement 1992;1():224-30.
1991: R V Ward; Susan J Atkinson; Patrick M Slocombe; Andrew J P Docherty; John J Reynolds; Gillian Murphy
Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes.
Biochimica et biophysica acta 1991;1079(2):242-6.
1991: Gillian Murphy; A Houbrechts; Mark Cockett; R A Williamson; M O'Shea; Andrew J P Docherty
The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity.
Biochemistry 1991;30(33):8097-102.
1991: R V Ward; Rosalind M Hembry; John J Reynolds; Gillian Murphy
The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue inhibitor of metalloproteinases-1.
The Biochemical journal 1991;278 ( Pt 1)():179-87.
1991: Gillian Murphy; Mark Cockett; R V Ward; Andrew J P Docherty
Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP).
The Biochemical journal 1991;277 ( Pt 1)():277-9.
1991: P A Koklitis; Gillian Murphy; C Sutton; S Angal
Purification of recombinant human prostromelysin. Studies on heat activation to give high-Mr and low-Mr active forms, and a comparison of recombinant with natural stromelysin activities.
The Biochemical journal 1991;276 ( Pt 1)():217-21.
1991: Paul Winyard; Z Zhang; K Chidwick; David R Blake; R W Carrell; Gillian Murphy
Proteolytic inactivation of human alpha 1 antitrypsin by human stromelysin.
FEBS letters 1991;279(1):91-4.
1991: Gillian Murphy
The regulation of connective tissue metalloproteinases by natural inhibitors.
Agents and actions. Supplements 1991;35():69-76.
1990: Gillian Murphy; Rosalind M Hembry; C E Hughes; Amanda J Fosang; T E Hardingham
Role and regulation of metalloproteinases in connective tissue turnover.
Biochemical Society transactions 1990;18(5):812-5.
1990: S Cooksley; J B Hipkiss; S P Tickle; E Holmes-Ievers; A J Docherty; Gillian Murphy; A D Lawson
Immunoassays for the detection of human collagenase, stromelysin, tissue inhibitor of metalloproteinases (TIMP) and enzyme-inhibitor complexes.
Matrix (Stuttgart, Germany) 1990;10(5):285-91.
1990: Andrew J P Docherty; Gillian Murphy
The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.
Annals of the rheumatic diseases 1990;49 Suppl 1():469-79.
1989: Gillian Murphy; P Koklitis; A F Carne
Dissociation of tissue inhibitor of metalloproteinases (TIMP) from enzyme complexes yields fully active inhibitor.
The Biochemical journal 1989;261(3):1031-4.
1989: Murray C Meikle; Susan J Atkinson; R V Ward; Gillian Murphy; John J Reynolds
Gingival fibroblasts degrade type I collagen films when stimulated with tumor necrosis factor and interleukin 1: evidence that breakdown is mediated by metalloproteinases.
Journal of periodontal research 1989;24(3):207-13.
1988: Gillian Murphy; H Nagase; C E Brinckerhoff
Relationship of procollagenase activator, stromelysin and matrix metalloproteinase 3.
Collagen and related research 1988;8(4):389-91.
1987: Gillian Murphy; Mark Cockett; PE Stephens; B J Smith; Andrew J P Docherty
Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes.
The Biochemical journal 1987;248(1):265-8.
1986: S E Whitham; Gillian Murphy; P Angel; H J Rahmsdorf; B J Smith; A Lyons; T J Harris; J J Reynolds; P Herrlich; Andrew J P Docherty
Comparison of human stromelysin and collagenase by cloning and sequence analysis.
The Biochemical journal 1986;240(3):913-6.
1985: Andrew J P Docherty; A Lyons; B J Smith; E M Wright; PE Stephens; T J Harris; Gillian Murphy; J J Reynolds
Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity.
Nature 1985;318(6041):66-9.