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Gillian Murphy

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
41
Knäuper, Vera
33
Docherty, Andrew
17
Atkinson, Susan
14
Lee, Meng-Huee
14
Cockett, Mark
13
Reynolds, John
13
Hembry, Rosalind
11
Hutton, Mike
10
Gavrilovic, Jelena
10
Edwards, Dylan
9
Amour, Augustin
8
Williamson, Richard
8
Stanton, Heather
8
Pendás, Alberto
8
Rapti, Magdalini

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Publications

TOP 3
Lee P J; Amos A; Robertson L; Fitzgerald B; Hoskin R; Lilburn M; Weetch E; Murphy G
Adults with late diagnosed PKU and severe challenging behaviour: a randomised placebo-controlled trial of a phenylalanine-restricted diet.
Murphy Gillian
Regulation of the proteolytic disintegrin metalloproteinases, the 'Sheddases'.
Boutet Philippe; Agüera-González Sonia; Atkinson Susan; Pennington Caroline J; Edwards Dylan R; Murphy Gillian; Reyburn Hugh T; Valés-Gómez Mar
Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein.

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All Publications

2009: Lee P J; Amos A; Robertson L; Fitzgerald B; Hoskin R; Lilburn M; Weetch E; Murphy G
Adults with late diagnosed PKU and severe challenging behaviour: a randomised placebo-controlled trial of a phenylalanine-restricted diet.
Journal of neurology, neurosurgery, and psychiatry 2009;80(6):631-5.
2009: Murphy Gillian
Regulation of the proteolytic disintegrin metalloproteinases, the 'Sheddases'.
Seminars in cell & developmental biology 2009;20(2):138-45.
2009: Boutet Philippe; Agüera-González Sonia; Atkinson Susan; Pennington Caroline J; Edwards Dylan R; Murphy Gillian; Reyburn Hugh T; Valés-Gómez Mar
Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):49-53.
2008: Murphy Gillian; Nagase Hideaki
Progress in matrix metalloproteinase research.
Molecular aspects of medicine 2008;29(5):290-308.
2008: Rapti Magdalini; Atkinson Susan J; Lee Meng-Huee; Trim Andrew; Moss Marcia; Murphy Gillian
The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition.
The Biochemical journal 2008;411(2):433-9.
2008: Murphy Gillian; Nagase Hideaki
Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?
Nature clinical practice. Rheumatology 2008;4(3):128-35.
2008: Murphy Gillian; Murthy Aditya; Khokha Rama
Clipping, shedding and RIPping keep immunity on cue.
Trends in immunology 2008;29(2):75-82.
2007: Lee Meng-Huee; Atkinson Susan; Murphy Gillian
Identification of the extracellular matrix (ECM) binding motifs of tissue inhibitor of metalloproteinases (TIMP)-3 and effective transfer to TIMP-1.
The Journal of biological chemistry 2007;282(9):6887-98.
2007: Hembry Rosalind M; Atkinson Susan J; Murphy Gillian
Assessment of gelatinase expression and activity in articular cartilage.
Methods in molecular medicine 2007;135():227-38.
2006: Rapti Magdalini; Knaüper Vera; Murphy Gillian; Williamson Richard A
Characterization of the AB loop region of TIMP-2. Involvement in pro-MMP-2 activation.
The Journal of biological chemistry 2006;281(33):23386-94.
2006: Atkinson Susan J; Roghi Christian; Murphy Gillian
MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells.
The Biochemical journal 2006;398(1):15-22.
2006: Chabottaux Vincent; Sounni Nor Eddine; Pennington Caroline J; English William R; van den Brûle Frédéric; Blacher Silvia; Gilles Christine; Munaut Carine; Maquoi Erik; Lopez-Otin Carlos; Murphy Gillian; Edwards Dylan R; Foidart Jean-Michel; Noël Agnès
Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases.
Cancer research 2006;66(10):5165-72.
2006: English Jane L; Kassiri Zamaneh; Koskivirta Ilpo; Atkinson Susan J; Di Grappa Marco; Soloway Paul D; Nagase Hideaki; Vuorio Eero; Murphy Gillian; Khokha Rama
Individual Timp deficiencies differentially impact pro-MMP-2 activation.
The Journal of biological chemistry 2006;281(15):10337-46.
2006: van de Kerkhof Peter C M; Kragballe Knud; Austad Joar; Berth-Jones John; Cambazard Frédéric; de la Brassinne Michel; Ljungberg Anders; Murphy Gillian; Papp Kim; Wozel Gottfried
Psoriasis: severity assessment in clinical practice. Conclusions from workshop discussions and a prospective multicentre survey of psoriasis severity.
European journal of dermatology : EJD 2006;16(2):167-71.
2006: Wallard M J; Pennington C J; Veerakumarasivam A; Burtt G; Mills I G; Warren A; Leung H Y; Murphy G; Edwards D R; Neal D E; Kelly J D
Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma.
British journal of cancer 2006;94(4):569-77.
2005: Murphy G; Lee M H
What are the roles of metalloproteinases in cartilage and bone damage?
Annals of the rheumatic diseases 2005;64 Suppl 4():iv44-7.
2005: Nisato Riccardo E; Hosseini Ghamartaj; Sirrenberg Christian; Butler Georgina S; Crabbe Thomas; Docherty Andrew J P; Wiesner Matthias; Murphy Gillian; Overall Christopher M; Goodman Simon L; Pepper Michael S
Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical.
Cancer research 2005;65(20):9377-87.
2005: Singh Robert J R; Mason Justin C; Lidington Elaine A; Edwards Dylan R; Nuttall Robert K; Khokha Rama; Knauper Vera; Murphy Gillian; Gavrilovic Jelena
Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3.
Cardiovascular research 2005;67(1):39-49.
2005: Soond Surinder M; Everson Bethany; Riches David W H; Murphy Gillian
ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking.
Journal of cell science 2005;118(Pt 11):2371-80.
2005: Lee Meng-Huee; Rapti Magdalini; Murphy Gillian
Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: fine-tuning TIMP-4 for optimal inhibition of tumor necrosis factor-{alpha}-converting enzyme.
The Journal of biological chemistry 2005;280(16):15967-75.
2004: Lee Meng-Huee; Rapti Magdalini; Murphy Gillian
Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme.
The Journal of biological chemistry 2004;279(43):45121-9.
2004: Holgate Stephen T; Davies Donna E; Rorke Steuart; Cakebread Julie; Murphy Gillian; Powell Robert M; Holloway John W
ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma.
Clinical reviews in allergy & immunology 2004;27(1):23-34.
2004: Lee Meng-Huee; Murphy Gillian
Matrix metalloproteinases at a glance.
Journal of cell science 2004;117(Pt 18):4015-6.
2004: Atkinson Susan J; English Jane L; Holway Nicholas; Murphy Gillian
Cellular cholesterol regulates MT1 MMP dependent activation of MMP 2 via MEK-1 in HT1080 fibrosarcoma cells.
FEBS letters 2004;566(1-3):65-70.
2004: Lee Meng-Huee; Rapti Magdalini; Knaüper Vera; Murphy Gillian
Threonine 98, the pivotal residue of tissue inhibitor of metalloproteinases (TIMP)-1 in metalloproteinase recognition.
The Journal of biological chemistry 2004;279(17):17562-9.
2004: Sounni Nor Eddine; Roghi Christian; Chabottaux Vincent; Janssen Mathias; Munaut Carine; Maquoi Erik; Galvez Beatriz G; Gilles Christine; Frankenne Francis; Murphy Gillian; Foidart Jean-Michel; Noel Agnès
Up-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases.
The Journal of biological chemistry 2004;279(14):13564-74.
2004: Rasmussen Fred H; Yeung Nolan; Kiefer Laura; Murphy Gillian; Lopez-Otin Carlos; Vitek Michael P; Moss Marcia L
Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases.
Biochemistry 2004;43(11):2987-95.
2003: Remacle Albert; Murphy Gillian; Roghi Christian
Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surface.
Journal of cell science 2003;116(Pt 19):3905-16.
2003: Lee Meng-Huee; Rapti Magdalini; Murphy Gillian
Unveiling the surface epitopes that render tissue inhibitor of metalloproteinase-1 inactive against membrane type 1-matrix metalloproteinase.
The Journal of biological chemistry 2003;278(41):40224-30.
2003: Wall S J; Sampson M J; Levell N; Murphy G
Elevated matrix metalloproteinase-2 and -3 production from human diabetic dermal fibroblasts.
The British journal of dermatology 2003;149(1):13-6.
2003: Holgate S T; Davies D E; Murphy G; Powell R M; Holloway J W
ADAM 33: just another asthma gene or a breakthrough in understanding the origins of bronchial hyperresponsiveness?
Thorax 2003;58(6):466-9.
2003: Worley Joanna R; Thompkins Philip B; Lee Meng H; Hutton Mike; Soloway Paul; Edwards Dylan R; Murphy Gillian; Knäuper Vera
Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP).
The Biochemical journal 2003;372(Pt 3):799-809.
2003: Lee Meng-Huee; Dodds Philippa; Verma Vandana; Maskos Klaus; Knäuper Vera; Murphy Gillian
Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-alpha converting enzyme.
The Biochemical journal 2003;371(Pt 2):369-76.
2003: Murphy Gillian; Knäuper Vera; Lee Meng-Huee; Amour Augustin; Worley Joanna R; Hutton Mike; Atkinson Susan; Rapti Magdalene; Williamson Richard
Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis: the specificity is in the detail.
Biochemical Society symposium 2003;(70):65-80.
2002: Knäuper Vera; Bailey Louise; Worley Joanna R; Soloway Paul; Patterson Margaret L; Murphy Gillian
Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13.
FEBS letters 2002;532(1-2):127-30.
2002: Lee Meng-Huee; Maskos Klaus; Knäuper Vera; Dodds Philippa; Murphy Gillian
Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)-3 using TIMP-1 as the scaffold: a new frontier in TIMP engineering.
Protein science : a publication of the Protein Society 2002;11(10):2493-503.
2002: Lafleur Marc A; Handsley Madeleine M; Knäuper Vera; Murphy Gillian; Edwards Dylan R
Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs).
Journal of cell science 2002;115(Pt 17):3427-38.
2002: Wall Steven J; Bevan Damon; Thomas David W; Harding Keith G; Edwards Dylan R; Murphy Gillian
Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse.
The Journal of investigative dermatology 2002;119(1):91-8.
2002: Amour Augustin; Knight C Graham; English William R; Webster Ailsa; Slocombe Patrick M; Knäuper Vera; Docherty Andrew J P; Becherer J David; Blobel Carl P; Murphy Gillian
The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs.
FEBS letters 2002;524(1-3):154-8.
2002: Lee Meng-Huee; Verma Vandana; Maskos Klaus; Becherer J David; Knäuper Vera; Dodds Philippa; Amour Augustin; Murphy Gillian
The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3.
FEBS letters 2002;520(1-3):102-6.
2002: Lee Meng-Huee; Verma Vandana; Maskos Klaus; Nath Deepa; Knäuper Vera; Dodds Philippa; Amour Augustin; Murphy Gillian
Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme.
The Biochemical journal 2002;364(Pt 1):227-34.
2002: Rodríguez-Manzaneque Juan Carlos; Westling Jennifer; Thai Shelley N-M; Luque Alfonso; Knauper Vera; Murphy Gillian; Sandy John D; Iruela-Arispe M Luisa
ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors.
Biochemical and biophysical research communications 2002;293(1):501-8.
2002: Bailey Louise; Wienke Dirk; Howard Matthew; Knäuper Vera; Isacke Clare M; Murphy Gillian
Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor.
The Biochemical journal 2002;363(Pt 1):67-72.
2002: Bond Mark; Murphy Gillian; Bennett Martin R; Newby Andrew C; Baker Andrew H
Tissue inhibitor of metalloproteinase-3 induces a Fas-associated death domain-dependent type II apoptotic pathway.
The Journal of biological chemistry 2002;277(16):13787-95.
2002: Poghosyan Zaruhi; Robbins Stephen M; Houslay Miles D; Webster Ailsa; Murphy Gillian; Edwards Dylan R
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.
The Journal of biological chemistry 2002;277(7):4999-5007.
2002: Yeow Karen M; Kishnani Narendra S; Hutton Mike; Hawkes Susan P; Murphy Gillian; Edwards Dylan R
Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix.
Matrix biology : journal of the International Society for Matrix Biology 2002;21(1):75-88.
2002: Murphy Gillian; Knäuper Vera; Atkinson Susan; Butler George; English William; Hutton Mike; Stracke Jan; Clark Ian
Matrix metalloproteinases in arthritic disease.
Arthritis research 2002;4 Suppl 3():S39-49.
2001: English W R; Holtz B; Vogt G; Knäuper V; Murphy G
Characterization of the role of the "MT-loop": an eight-amino acid insertion specific to progelatinase A (MMP2) activating membrane-type matrix metalloproteinases.
The Journal of biological chemistry 2001;276(45):42018-26.
2001: Ellis V; Murphy G
Cellular strategies for proteolytic targeting during migration and invasion.
FEBS letters 2001;506(1):1-5.
2001: Patterson M L; Atkinson S J; Knäuper V; Murphy G
Specific collagenolysis by gelatinase A, MMP-2, is determined by the hemopexin domain and not the fibronectin-like domain.
FEBS letters 2001;503(2-3):158-62.
2001: Williamson R A; Hutton M; Vogt G; Rapti M; Knäuper V; Carr M D; Murphy G
Tyrosine 36 plays a critical role in the interaction of the AB loop of tissue inhibitor of metalloproteinases-2 with matrix metalloproteinase-14.
The Journal of biological chemistry 2001;276(35):32966-70.
2001: Lafleur M A; Hollenberg M D; Atkinson S J; Knäuper V; Murphy G; Edwards D R
Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species.
The Biochemical journal 2001;357(Pt 1):107-15.
2001: Hembry R M; Dyce J; Driesang I; Hunziker E B; Fosang A J; Tyler J A; Murphy G
Immunolocalization of matrix metalloproteinases in partial-thickness defects in pig articular cartilage. A preliminary report.
The Journal of bone and joint surgery. American volume 2001;83-A(6):826-38.
2001: Lafleur M A; Forsyth P A; Atkinson S J; Murphy G; Edwards D R
Perivascular cells regulate endothelial membrane type-1 matrix metalloproteinase activity.
Biochemical and biophysical research communications 2001;282(2):463-73.
2001: Knäuper V; Patterson M L; Gomis-Rüth F X; Smith B; Lyons A; Docherty A J; Murphy G
The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity.
European journal of biochemistry / FEBS 2001;268(6):1888-96.
2001: Atkinson S J; Patterson M L; Butler M J; Murphy G
Membrane type 1 matrix metalloproteinase and gelatinase A synergistically degrade type 1 collagen in a cell model.
FEBS letters 2001;491(3):222-6.
2001: Nath D; Williamson N J; Jarvis R; Murphy G
Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase.
Journal of cell science 2001;114(Pt 6):1213-20.
2001: Balbín M; Fueyo A; Knäuper V; López J M; Alvarez J; Sánchez L M; Quesada V; Bordallo J; Murphy G; López-Otín C
Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.
The Journal of biological chemistry 2001;276(13):10253-62.
2001: English W R; Velasco G; Stracke J O; Knäuper V; Murphy G
Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25).
FEBS letters 2001;491(1-2):137-42.
2001: Lee M H; Knäuper V; Becherer J D; Murphy G
Full-length and N-TIMP-3 display equal inhibitory activities toward TNF-alpha convertase.
Biochemical and biophysical research communications 2001;280(3):945-50.
2001: Knäuper V; Murphy G
Methods for studying activation of matrix metalloproteinases.
Methods in molecular biology (Clifton, N.J.) 2001;151():377-87.
2000: Bond M; Murphy G; Bennett M R; Amour A; Knauper V; Newby A C; Baker A H
Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus. Metalloproteinase inhibition is associated with proapoptotic activity.
The Journal of biological chemistry 2000;275(52):41358-63.
2000: Stracke J O; Fosang A J; Last K; Mercuri F A; Pendás A M; Llano E; Perris R; Di Cesare P E; Murphy G; Knäuper V
Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).
FEBS letters 2000;478(1-2):52-6.
2000: Nath D; Slocombe P M; Webster A; Stephens P E; Docherty A J; Murphy G
Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1 )integrin, leading to a marked induction of fibroblast cell motility.
Journal of cell science 2000;113 ( Pt 12)():2319-28.
2000: Stringa E; Knäuper V; Murphy G; Gavrilovic J
Collagen degradation and platelet-derived growth factor stimulate the migration of vascular smooth muscle cells.
Journal of cell science 2000;113 ( Pt 11)():2055-64.
2000: Amour A; Knight C G; Webster A; Slocombe P M; Stephens P E; Knäuper V; Docherty A J; Murphy G
The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3.
FEBS letters 2000;473(3):275-9.
2000: Stracke J O; Hutton M; Stewart M; Pendás A M; Smith B; López-Otin C; Murphy G; Knäuper V
Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme.
The Journal of biological chemistry 2000;275(20):14809-16.
2000: English W R; Puente X S; Freije J M; Knauper V; Amour A; Merryweather A; Lopez-Otin C; Murphy G
Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2.
The Journal of biological chemistry 2000;275(19):14046-55.
2000: Maquoi E; Frankenne F; Baramova E; Munaut C; Sounni N E; Remacle A; Noël A; Murphy G; Foidart J M
Membrane type 1 matrix metalloproteinase-associated degradation of tissue inhibitor of metalloproteinase 2 in human tumor cell lines.
The Journal of biological chemistry 2000;275(15):11368-78.
2000: Dew G; Murphy G; Stanton H; Vallon R; Angel P; Reynolds J J; Hembry R M
Localisation of matrix metalloproteinases and TIMP-2 in resorbing mouse bone.
Cell and tissue research 2000;299(3):385-94.
1999: Maidment J M; Moore D; Murphy G P; Murphy G; Clark I M
Matrix metalloproteinase homologues from Arabidopsis thaliana. Expression and activity.
The Journal of biological chemistry 1999;274(49):34706-10.
1999: Breckon J J; Papaioannou S; Kon L W; Tumber A; Hembry R M; Murphy G; Reynolds J J; Meikle M C
Stromelysin (MMP-3) synthesis is up-regulated in estrogen-deficient mouse osteoblasts in vivo and in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(11):1880-90.
1999: Murphy G; Gavrilovic J
Proteolysis and cell migration: creating a path?
Current opinion in cell biology 1999;11(5):614-21.
1999: Butler G S; Hutton M; Wattam B A; Williamson R A; Knäuper V; Willenbrock F; Murphy G
The specificity of TIMP-2 for matrix metalloproteinases can be modified by single amino acid mutations.
The Journal of biological chemistry 1999;274(29):20391-6.
1999: Amour A; Hutton M; Knäuper V; Slocombe P M; Webster A; Butler M; Knight C G; Smith B J; Docherty A J; Murphy G
Inhibition of the metalloproteinase domain of mouse TACE.
Annals of the New York Academy of Sciences 1999;878():728-31.
1999: Hutton M; Butler G S; Wattam B A; Willenbrock F; Williamson R A; Murphy G
Analysis of the interaction of TIMP-2 and MMPs: engineering the changes.
Annals of the New York Academy of Sciences 1999;878():524-7.
1999: Murphy G; Knäuper V; Cowell S; Hembry R; Stanton H; Butler G; Freije J; Pendás A M; López-Otín C
Evaluation of some newer matrix metalloproteinases.
Annals of the New York Academy of Sciences 1999;878():25-39.
1999: Llano E; Pendás A M; Freije J P; Nakano A; Knäuper V; Murphy G; López-Otin C
Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors.
Cancer research 1999;59(11):2570-6.
1999: Butler G S; Apte S S; Willenbrock F; Murphy G
Human tissue inhibitor of metalloproteinases 3 interacts with both the N- and C-terminal domains of gelatinases A and B. Regulation by polyanions.
The Journal of biological chemistry 1999;274(16):10846-51.
1999: Baker A H; George S J; Zaltsman A B; Murphy G; Newby A C
Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3.
British journal of cancer 1999;79(9-10):1347-55.
1999: Velasco G; Pendás A M; Fueyo A; Knäuper V; Murphy G; López-Otín C
Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members.
The Journal of biological chemistry 1999;274(8):4570-6.
1999: Nath D; Slocombe P M; Stephens P E; Warn A; Hutchinson G R; Yamada K M; Docherty A J; Murphy G
Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells.
Journal of cell science 1999;112 ( Pt 4)():579-87.
1999: Murphy G; Stanton H; Cowell S; Butler G; Knäuper V; Atkinson S; Gavrilovic J
Mechanisms for pro matrix metalloproteinase activation.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1999;107(1):38-44.
1998: Amour A; Slocombe P M; Webster A; Butler M; Knight C G; Smith B J; Stephens P E; Shelley C; Hutton M; Knäuper V; Docherty A J; Murphy G
TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3.
FEBS letters 1998;435(1):39-44.
1998: Balbín M; Fueyo A; Knäuper V; Pendás A M; López J M; Jiménez M G; Murphy G; López-Otín C
Collagenase 2 (MMP-8) expression in murine tissue-remodeling processes. Analysis of its potential role in postpartum involution of the uterus.
The Journal of biological chemistry 1998;273(37):23959-68.
1998: Stanton H; Gavrilovic J; Atkinson S J; d'Ortho M P; Yamada K M; Zardi L; Murphy G
The activation of ProMMP-2 (gelatinase A) by HT1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP-14) to a 45 kDa form.
Journal of cell science 1998;111 ( Pt 18)():2789-98.
1998: Hutton M; Willenbrock F; Brocklehurst K; Murphy G
Kinetic analysis of the mechanism of interaction of full-length TIMP-2 and gelatinase A: evidence for the existence of a low-affinity intermediate.
Biochemistry 1998;37(28):10094-8.
1998: Cowell S; Knäuper V; Stewart M L; D'Ortho M P; Stanton H; Hembry R M; López-Otín C; Reynolds J J; Murphy G
Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3.
The Biochemical journal 1998;331 ( Pt 2)():453-8.
1998: Messent A J; Tuckwell D S; Knäuper V; Humphries M J; Murphy G; Gavrilovic J
Effects of collagenase-cleavage of type I collagen on alpha2beta1 integrin-mediated cell adhesion.
Journal of cell science 1998;111 ( Pt 8)():1127-35.
1998: Maquoi E; Noël A; Frankenne F; Angliker H; Murphy G; Foidart J M
Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor.
FEBS letters 1998;424(3):262-6.
1998: d'Ortho M P; Stanton H; Butler M; Atkinson S J; Murphy G; Hembry R M
MT1-MMP on the cell surface causes focal degradation of gelatin films.
FEBS letters 1998;421(2):159-64.
1998: Butler G S; Butler M J; Atkinson S J; Will H; Tamura T; Schade van Westrum S; Crabbe T; Clements J; d'Ortho M P; Murphy G
The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study.
The Journal of biological chemistry 1998;273(2):871-80.
1998: Cockett M I; Murphy G; Birch M L; O'Connell J P; Crabbe T; Millican A T; Hart I R; Docherty A J
Matrix metalloproteinases and metastatic cancer.
Biochemical Society symposium 1998;63():295-313.
1997: d'Ortho M P; Will H; Atkinson S; Butler G; Messent A; Gavrilovic J; Smith B; Timpl R; Zardi L; Murphy G
Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases.
European journal of biochemistry / FEBS 1997;250(3):751-7.
1997: Llano E; Pendás A M; Knäuper V; Sorsa T; Salo T; Salido E; Murphy G; Simmer J P; Bartlett J D; López-Otín C
Identification and structural and functional characterization of human enamelysin (MMP-20).
Biochemistry 1997;36(49):15101-8.
1997: Knäuper V; Smith B; López-Otin C; Murphy G
Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13).
European journal of biochemistry / FEBS 1997;248(2):369-73.
1997: Murphy G; Knäuper V
Relating matrix metalloproteinase structure to function: why the "hemopexin" domain?
Matrix biology : journal of the International Society for Matrix Biology 1997;15(8-9):511-8.
1997: Butler G S; Will H; Atkinson S J; Murphy G
Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases.
European journal of biochemistry / FEBS 1997;244(2):653-7.
1997: Knäuper V; Docherty A J; Smith B; Tschesche H; Murphy G
Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP-8) to stability and collagenolytic activity by alanine scanning mutagenesis.
FEBS letters 1997;405(1):60-4.
1997: Knäuper V; Cowell S; Smith B; López-Otin C; O'Shea M; Morris H; Zardi L; Murphy G
The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction.
The Journal of biological chemistry 1997;272(12):7608-16.
1997: Pendás A M; Knäuper V; Puente X S; Llano E; Mattei M G; Apte S; Murphy G; López-Otín C
Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution.
The Journal of biological chemistry 1997;272(7):4281-6.
1996: Gomis-Rüth F X; Gohlke U; Betz M; Knäuper V; Murphy G; López-Otín C; Bode W
The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain.
Journal of molecular biology 1996;264(3):556-66.
1996: Eble J A; Ries A; Lichy A; Mann K; Stanton H; Gavrilovic J; Murphy G; Kühn K
The recognition sites of the integrins alpha1beta1 and alpha2beta1 within collagen IV are protected against gelatinase A attack in the native protein.
The Journal of biological chemistry 1996;271(48):30964-70.
1996: Williamson R A; Natalia D; Gee C K; Murphy G; Carr M D; Freedman R B
Chemically and conformationally authentic active domain of human tissue inhibitor of metalloproteinases-2 refolded from bacterial inclusion bodies.
European journal of biochemistry / FEBS 1996;241(2):476-83.
1996: Sasaki T; Mann K; Murphy G; Chu M L; Timpl R
Different susceptibilities of fibulin-1 and fibulin-2 to cleavage by matrix metalloproteinases and other tissue proteases.
European journal of biochemistry / FEBS 1996;240(2):427-34.
1996: Will H; Atkinson S J; Butler G S; Smith B; Murphy G
The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3.
The Journal of biological chemistry 1996;271(29):17119-23.
1996: Knäuper V; Will H; López-Otin C; Smith B; Atkinson S J; Stanton H; Hembry R M; Murphy G
Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme.
The Journal of biological chemistry 1996;271(29):17124-31.
1996: Knäuper V; López-Otin C; Smith B; Knight G; Murphy G
Biochemical characterization of human collagenase-3.
The Journal of biological chemistry 1996;271(3):1544-50.
1996: Gohlke U; Gomis-Rüth F X; Crabbe T; Murphy G; Docherty A J; Bode W
The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function.
FEBS letters 1996;378(2):126-30.
1995: Atkinson S J; Crabbe T; Cowell S; Ward R V; Butler M J; Sato H; Seiki M; Reynolds J J; Murphy G
Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes.
The Journal of biological chemistry 1995;270(51):30479-85.
1995: Willenbrock F; Knight C G; Murphy G; Phillips I R; Brocklehurst K
Evidence for the importance of weakly bound water for matrix metalloproteinase activity.
Biochemistry 1995;34(37):12012-8.
1995: Allan J A; Docherty A J; Barker P J; Huskisson N S; Reynolds J J; Murphy G
Binding of gelatinases A and B to type-I collagen and other matrix components.
The Biochemical journal 1995;309 ( Pt 1)():299-306.
1995: Willenbrock F; Murphy G; Phillips I R; Brocklehurst K
The second zinc atom in the matrix metalloproteinase catalytic domain is absent in the full-length enzymes: a possible role for the C-terminal domain.
FEBS letters 1995;358(2):189-92.
1995: Murphy G; Willenbrock F
Tissue inhibitors of matrix metalloendopeptidases.
Methods in enzymology 1995;248():496-510.
1995: Murphy G; Crabbe T
Gelatinases A and B.
Methods in enzymology 1995;248():470-84.
1994: Willenbrock F; Murphy G
Structure-function relationships in the tissue inhibitors of metalloproteinases.
American journal of respiratory and critical care medicine 1994;150(6 Pt 2):S165-70.
1994: Ward R V; Atkinson S J; Reynolds J J; Murphy G
Cell surface-mediated activation of progelatinase A: demonstration of the involvement of the C-terminal domain of progelatinase A in cell surface binding and activation of progelatinase A by primary fibroblasts.
The Biochemical journal 1994;304 ( Pt 1)():263-9.
1994: Hill P A; Murphy G; Docherty A J; Hembry R M; Millican T A; Reynolds J J; Meikle M C
The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts.
Journal of cell science 1994;107 ( Pt 11)():3055-64.
1994: Williamson R A; Martorell G; Carr M D; Murphy G; Docherty A J; Freedman R B; Feeney J
Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family.
Biochemistry 1994;33(39):11745-59.
1994: Knäuper V; Murphy G; Tschesche H
Neutrophil procollagenase can be activated by stromelysin-2.
Annals of the New York Academy of Sciences 1994;732():367-8.
1994: Allan J A; Docherty A J; Murphy G
The binding of gelatinases A and B to type I collagen yields both high and low affinity sites.
Annals of the New York Academy of Sciences 1994;732():365-6.
1994: Murphy G; Willenbrock F; Crabbe T; O'Shea M; Ward R; Atkinson S; O'Connell J; Docherty A
Regulation of matrix metalloproteinase activity.
Annals of the New York Academy of Sciences 1994;732():31-41.
1994: Williamson R A; Bartels H; Murphy G; Freedman R B
Folding and stability of the active N-terminal domain of tissue inhibitor of metalloproteinases-1 and -2.
Protein engineering 1994;7(8):1035-40.
1994: O'Connell J P; Willenbrock F; Docherty A J; Eaton D; Murphy G
Analysis of the role of the COOH-terminal domain in the activation, proteolytic activity, and tissue inhibitor of metalloproteinase interactions of gelatinase B.
The Journal of biological chemistry 1994;269(21):14967-73.
1994: Crabbe T; Zucker S; Cockett M I; Willenbrock F; Tickle S; O'Connell J P; Scothern J M; Murphy G; Docherty A J
Mutation of the active site glutamic acid of human gelatinase A: effects on latency, catalysis, and the binding of tissue inhibitor of metalloproteinases-1.
Biochemistry 1994;33(21):6684-90.
1994: Zhang Z; Winyard P G; Chidwick K; Murphy G; Wardell M; Carrell R W; Blake D R
Proteolysis of human native and oxidised alpha 1-proteinase inhibitor by matrilysin and stromelysin.
Biochimica et biophysica acta 1994;1199(2):224-8.
1994: Murphy G; Nguyen Q; Cockett M I; Atkinson S J; Allan J A; Knight C G; Willenbrock F; Docherty A J
Assessment of the role of the fibronectin-like domain of gelatinase A by analysis of a deletion mutant.
The Journal of biological chemistry 1994;269(9):6632-6.
1994: Nguyen Q; Willenbrock F; Cockett M I; O'Shea M; Docherty A J; Murphy G
Different domain interactions are involved in the binding of tissue inhibitors of metalloproteinases to stromelysin-1 and gelatinase A.
Biochemistry 1994;33(8):2089-95.
1993: Tolley S P; Davies G J; O'Shea M; Cockett M I; Docherty A J; Murphy G
Crystallization and preliminary X-ray analysis of nonglycosylated tissue inhibitor of metalloproteinases-1, N30QN78Q TIMP-1.
Proteins 1993;17(4):435-7.
1993: Mayer U; Mann K; Timpl R; Murphy G
Sites of nidogen cleavage by proteases involved in tissue homeostasis and remodelling.
European journal of biochemistry / FEBS 1993;217(3):877-84.
1993: Hembry R M; Bagga M R; Murphy G; Henderson B; Reynolds J J
Rabbit models of arthritis: immunolocalization of matrix metalloproteinases and tissue inhibitor of metalloproteinase in synovium and cartilage.
The American journal of pathology 1993;143(2):628-42.
1993: Murphy G; Segain J P; O'Shea M; Cockett M; Ioannou C; Lefebvre O; Chambon P; Basset P
The 28-kDa N-terminal domain of mouse stromelysin-3 has the general properties of a weak metalloproteinase.
The Journal of biological chemistry 1993;268(21):15435-41.
1993: Williamson R A; Smith B J; Angal S; Murphy G; Freedman R B
Structural analysis of tissue inhibitor of metalloproteinases-1 (TIMP-1) by tryptic peptide mapping.
Biochimica et biophysica acta 1993;1164(1):8-16.
1993: Willenbrock F; Crabbe T; Slocombe P M; Sutton C W; Docherty A J; Cockett M I; O'Shea M; Brocklehurst K; Phillips I R; Murphy G
The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A.
Biochemistry 1993;32(16):4330-7.
1993: Tolley S; Murphy G; O'Shea M; Ward R; Docherty A; Cockett M; Rawas A; Davies G
Crystallization and preliminary X-ray analysis of a truncated tissue metalloproteinase inhibitor delta 128-194 TIMP-2.
Journal of molecular biology 1993;229(4):1163-4.
1992: Atkinson S J; Ward R V; Reynolds J J; Murphy G
Cell-mediated degradation of type IV collagen and gelatin films is dependent on the activation of matrix metalloproteinases.
The Biochemical journal 1992;288 ( Pt 2)():605-11.
1992: Murphy G; Atkinson S; Ward R; Gavrilovic J; Reynolds J J
The role of plasminogen activators in the regulation of connective tissue metalloproteinases.
Annals of the New York Academy of Sciences 1992;667():1-12.
1992: O'Shea M; Willenbrock F; Williamson R A; Cockett M I; Freedman R B; Reynolds J J; Docherty A J; Murphy G
Site-directed mutations that alter the inhibitory activity of the tissue inhibitor of metalloproteinases-1: importance of the N-terminal region between cysteine 3 and cysteine 13.
Biochemistry 1992;31(42):10146-52.
1992: Crabbe T; Willenbrock F; Eaton D; Hynds P; Carne A F; Murphy G; Docherty A J
Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases.
Biochemistry 1992;31(36):8500-7.
1992: Murphy G; Docherty A J
The matrix metalloproteinases and their inhibitors.
American journal of respiratory cell and molecular biology 1992;7(2):120-5.
1992: Docherty A J; O'Connell J; Crabbe T; Angal S; Murphy G
The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases.
Trends in biotechnology 1992;10(6):200-7.
1992: Murphy G; Willenbrock F; Ward R V; Cockett M I; Eaton D; Docherty A J
The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases.
The Biochemical journal 1992;283 ( Pt 3)():637-41.
1992: Murphy G; Allan J A; Willenbrock F; Cockett M I; O'Connell J P; Docherty A J
The role of the C-terminal domain in collagenase and stromelysin specificity.
The Journal of biological chemistry 1992;267(14):9612-8.
1992: Murphy G; Hembry R M
Proteinases in rheumatoid arthritis.
The Journal of rheumatology. Supplement 1992;32():61-4.
1992: Knight C G; Willenbrock F; Murphy G
A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases.
FEBS letters 1992;296(3):263-6.
1992: Murphy G
Dissociation of tissue inhibitor of metalloproteinases (TIMP) from enzyme complexes yields fully active inhibitor.
Matrix (Stuttgart, Germany). Supplement 1992;1():323-4.
1992: Murphy G; Ward R; Gavrilovic J; Atkinson S
Physiological mechanisms for metalloproteinase activation.
Matrix (Stuttgart, Germany). Supplement 1992;1():224-30.
1991: Ward R V; Atkinson S J; Slocombe P M; Docherty A J; Reynolds J J; Murphy G
Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes.
Biochimica et biophysica acta 1991;1079(2):242-6.
1991: Ward R V; Hembry R M; Reynolds J J; Murphy G
The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue inhibitor of metalloproteinases-1.
The Biochemical journal 1991;278 ( Pt 1)():179-87.
1991: Murphy G; Houbrechts A; Cockett M I; Williamson R A; O'Shea M; Docherty A J
The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity.
Biochemistry 1991;30(33):8097-102.
1991: Murphy G; Cockett M I; Ward R V; Docherty A J
Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP).
The Biochemical journal 1991;277 ( Pt 1)():277-9.
1991: Koklitis P A; Murphy G; Sutton C; Angal S
Purification of recombinant human prostromelysin. Studies on heat activation to give high-Mr and low-Mr active forms, and a comparison of recombinant with natural stromelysin activities.
The Biochemical journal 1991;276 ( Pt 1)():217-21.
1991: Winyard P G; Zhang Z; Chidwick K; Blake D R; Carrell R W; Murphy G
Proteolytic inactivation of human alpha 1 antitrypsin by human stromelysin.
FEBS letters 1991;279(1):91-4.
1991: Murphy G
The regulation of connective tissue metalloproteinases by natural inhibitors.
Agents and actions. Supplements 1991;35():69-76.
1990: Murphy G; Hembry R M; Hughes C E; Fosang A J; Hardingham T E
Role and regulation of metalloproteinases in connective tissue turnover.
Biochemical Society transactions 1990;18(5):812-5.
1990: Cooksley S; Hipkiss J B; Tickle S P; Holmes-Ievers E; Docherty A J; Murphy G; Lawson A D
Immunoassays for the detection of human collagenase, stromelysin, tissue inhibitor of metalloproteinases (TIMP) and enzyme-inhibitor complexes.
Matrix (Stuttgart, Germany) 1990;10(5):285-91.
1990: Docherty A J; Murphy G
The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.
Annals of the rheumatic diseases 1990;49 Suppl 1():469-79.
1989: Murphy G; Koklitis P; Carne A F
Dissociation of tissue inhibitor of metalloproteinases (TIMP) from enzyme complexes yields fully active inhibitor.
The Biochemical journal 1989;261(3):1031-4.
1989: Meikle M C; Atkinson S J; Ward R V; Murphy G; Reynolds J J
Gingival fibroblasts degrade type I collagen films when stimulated with tumor necrosis factor and interleukin 1: evidence that breakdown is mediated by metalloproteinases.
Journal of periodontal research 1989;24(3):207-13.
1988: Murphy G; Nagase H; Brinckerhoff C E
Relationship of procollagenase activator, stromelysin and matrix metalloproteinase 3.
Collagen and related research 1988;8(4):389-91.
1987: Murphy G; Cockett M I; Stephens P E; Smith B J; Docherty A J
Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes.
The Biochemical journal 1987;248(1):265-8.
1986: Whitham S E; Murphy G; Angel P; Rahmsdorf H J; Smith B J; Lyons A; Harris T J; Reynolds J J; Herrlich P; Docherty A J
Comparison of human stromelysin and collagenase by cloning and sequence analysis.
The Biochemical journal 1986;240(3):913-6.
1985: Docherty A J; Lyons A; Smith B J; Wright E M; Stephens P E; Harris T J; Murphy G; Reynolds J J
Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity.
Nature 1985;318(6041):66-9.

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