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Michael Murphy

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Carolyn M Porteous; Robin A J Smith; Franklin I Aigbirhio; David K Menon; Michael P Murphy
P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain.
Ruth M Mackenzie; William H Miller; Michael P Murphy; Ian P Salt; Jane A Dymott; Carlene A Hamilton; Hagar A Ibrahim; Angela Logan; Andrea Degasperi; Christian Delles; Anna F Dominiczak
Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes.
Peter G Finichiu; Andrew M James; Lesley Larsen; Robin A J Smith; Michael P Murphy
Mitochondrial accumulation of a lipophilic cation conjugated to an ionisable group depends on membrane potential, pH gradient and pK(a): implications for the design of mitochondrial probes and therapies.

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2013: Carolyn M Porteous; Robin A J Smith; Franklin I Aigbirhio; David K Menon; Michael P Murphy
P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain.
Biochimica et biophysica acta 2013;1830(6):3458-65.
2013: Ruth M Mackenzie; William H Miller; Michael P Murphy; Ian P Salt; Jane A Dymott; Carlene A Hamilton; Hagar A Ibrahim; Angela Logan; Andrea Degasperi; Christian Delles; Anna F Dominiczak
Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes.
Clinical science (London, England : 1979) 2013;124(6):403-11.
2013: Peter G Finichiu; Andrew M James; Lesley Larsen; Robin A J Smith; Michael P Murphy
Mitochondrial accumulation of a lipophilic cation conjugated to an ionisable group depends on membrane potential, pH gradient and pK(a): implications for the design of mitochondrial probes and therapies.
Journal of bioenergetics and biomembranes 2013;45(1-2):165-73.
2012: Geoffrey F Kelso; Angela Logan; Andrej Maroz; Michael P Murphy; Alexander V Peskin; Carolyn M Porteous; Tracy A Prime; Meredith F Ross; Robert F Anderson; Sally Brooker; Helena M Cochemé; Andrew M James; Christine C Winterbourn; Robin A J Smith
A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic.
Chemistry & biology 2012;19(10):1237-46.
2012: Thomas R Hurd; Michael P Murphy; Tracy A Prime; Irina Abakumova; Bartlomiej Baranowski; Edward T Chouchani; Yvonne Collins; Ian M Fearnley; Andrew M James
Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species.
The Journal of biological chemistry 2012;287(42):35153-60.
2012: Tracy A Prime; Robin A J Smith; Peter G Finichiu; Marleen Forkink; Werner J H Koopman; Lesley Larsen; Melissa J Latter; Pamela Boon Li Pun; Angela Logan; Jennifer McLachlan; Michael P Murphy
A ratiometric fluorescent probe for assessing mitochondrial phospholipid peroxidation within living cells.
Free radical biology & medicine 2012;53(3):544-53.
2012: Robin A J Smith; Helena M Cochemé; Richard C Hartley; Michael P Murphy
Mitochondrial pharmacology.
Trends in pharmacological sciences 2012;33(6):341-52.
2012: Helena M Cochemé; Ian M Fearnley; Richard C Hartley; Andrew M James; Angela Logan; Stephen J McQuaker; Linda Partridge; Jigna V Patel; Carolyn M Porteous; Tracy A Prime; Caroline Quin; Robin A J Smith; Irina Abakumova; Michael P Murphy
Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila.
Nature protocols 2012;7(5):946-58.
2012: Sean M Davidson; Michael P Murphy; Derek M Yellon; Michael R Duchen
Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation.
Cardiovascular research 2012;93(3):445-53.
2012: Yvonne Collins; Andrew M James; Katja E Menger; Edward T Chouchani; Helena M Cochemé; Michael P Murphy
Mitochondrial redox signalling at a glance.
Journal of cell science 2012;125(Pt 4):801-6.
2012: Susan Chalmers; Andrew G Cairns; Stuart T Caldwell; Andrew M James; John G McCarron; Michael P Murphy; Tracy A Prime; Caroline Quin; Richard C Hartley
Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore.
Journal of the American Chemical Society 2012;134(2):758-61.
2012: Michael P Murphy
Modulating mitochondrial intracellular location as a redox signal.
Science signaling 2012;5(242):pe39.
2012: Pamela Boon Li Pun; Michael P Murphy
Pathological significance of mitochondrial glycation.
International journal of cell biology 2012;2012():843505.
2011: Robin A J Smith; Richard C Hartley; Michael P Murphy
Mitochondria-targeted small molecule therapeutics and probes.
Antioxidants & redox signaling 2011;15(12):3021-38.
2011: Helena M Cochemé; Caroline Quin; Stephen J McQuaker; Filipe Cabreiro; Angela Logan; Tracy A Prime; Irina Abakumova; Jigna V Patel; Ian M Fearnley; Andrew M James; Carolyn M Porteous; Robin A J Smith; Saima Saeed; Jane E Carré; Mervyn Singer; David Gems; Richard C Hartley; Linda Partridge; Michael P Murphy
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix.
Cell metabolism 2011;13(3):340-50.
2011: Robin A J Smith; Michael P Murphy
Mitochondria-targeted antioxidants as therapies.
Discovery medicine 2011;11(57):106-14.
2010: Aiwu Zhou; Robin W Carrell; Michael P Murphy; Zhenquan Wei; Yahui Yan; Peter L D Stanley; Penelope E Stein; Fiona Broughton Pipkin; Randy J Read
A redox switch in angiotensinogen modulates angiotensin release.
Nature 2010;468(7320):108-11.
2010: Carolyn M Porteous; Angela Logan; Cameron Evans; Elizabeth C Ledgerwood; David K Menon; Franklin Aigbirhio; Robin A J Smith; Michael P Murphy
Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes.
Biochimica et biophysica acta 2010;1800(9):1009-17.
2010: Robin A J Smith; Michael P Murphy
Animal and human studies with the mitochondria-targeted antioxidant MitoQ.
Annals of the New York Academy of Sciences 2010;1201():96-103.
2010: Helena M Cochemé; Michael P Murphy
Can antioxidants be effective therapeutics?
Current opinion in investigational drugs (London, England : 2000) 2010;11(4):426-31.
2010: Sergio Rodriguez-Cuenca; Helena M Cochemé; Angela Logan; Irina Abakumova; Tracy A Prime; Claudia Rose; antonio vidal-puig; Anthony C Smith; David C Rubinsztein; Ian M Fearnley; Bruce A Jones; Simon Pope; Simon J R Heales; Brian Y H Lam; Sudeshna Guha Neogi; Ian McFarlane; Andrew M James; Robin A J Smith; Michael P Murphy
Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice.
Free radical biology & medicine 2010;48(1):161-72.
2009: Delyth Graham; Ngan N Huynh; Carlene A Hamilton; Elisabeth Beattie; Robin A J Smith; Helena M Cochemé; Michael P Murphy; Anna F Dominiczak
Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy.
Hypertension 2009;54(2):322-8.
2009: Helena M Cochemé; Michael P Murphy
Chapter 22 The uptake and interactions of the redox cycler paraquat with mitochondria.
Methods in enzymology 2009;456():395-417.
2009: Michael P Murphy
How mitochondria produce reactive oxygen species.
The Biochemical journal 2009;417(1):1-13.
2009: Jan Trnka; Frances H Blaikie; Angela Logan; Robin A J Smith; Michael P Murphy
Antioxidant properties of MitoTEMPOL and its hydroxylamine.
Free radical research 2009;43(1):4-12.
2008: Thomas R Hurd; Raquel Requejo; Aleksandra Filipovska; Stephanie Brown; Tracy A Prime; Alan J Robinson; Ian M Fearnley; Michael P Murphy
Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage.
The Journal of biological chemistry 2008;283(36):24801-15.
2008: Catherine E Hobbs; Michael P Murphy; Robin A J Smith; Dorothy E Oorschot
Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN.
Pediatrics international : official journal of the Japan Pediatric Society 2008;50(4):481-8.
2008: Michael P Murphy
Targeting lipophilic cations to mitochondria.
Biochimica et biophysica acta 2008;1777(7-8):1028-31.
2008: Meredith F Ross; Tracy A Prime; Irina Abakumova; Andrew M James; Carolyn M Porteous; Robin A J Smith; Michael P Murphy
Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells.
The Biochemical journal 2008;411(3):633-45.
2008: Jan Trnka; Frances H Blaikie; Robin A J Smith; Michael P Murphy
A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria.
Free radical biology & medicine 2008;44(7):1406-19.
2008: Helena M Cochemé; Michael P Murphy
Complex I is the major site of mitochondrial superoxide production by paraquat.
The Journal of biological chemistry 2008;283(4):1786-98.
2008: Michael P Murphy; Linda Partridge
Toward a control theory analysis of aging.
Annual review of biochemistry 2008;77():777-98.
2007: Phing-How Lou; Birgit S Hansen; Preben H Olsen; Søren Tullin; Michael P Murphy; Martin D Brand
Mitochondrial uncouplers with an extraordinary dynamic range.
The Biochemical journal 2007;407(1):129-40.
2007: Reagan M Jarvis; Jana Göttert; Michael P Murphy; Elizabeth C Ledgerwood
Mitochondria-targeted antioxidants do not prevent tumour necrosis factor-induced necrosis of L929 cells.
Free radical research 2007;41(9):1041-6.
2007: Thomas R Hurd; Tracy A Prime; Michael E Harbour; Kathryn S Lilley; Michael P Murphy
Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling.
The Journal of biological chemistry 2007;282(30):22040-51.
2007: Stephanie E Brown; Meredith F Ross; Alejandra Sanjuan-Pla; Abdul-Rahman B Manas; Robin A J Smith; Michael P Murphy
Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative.
Free radical biology & medicine 2007;42(12):1766-80.
2007: Helena M Cochemé; Geoffrey F Kelso; Andrew M James; Meredith F Ross; Jan Trnka; Thabo Mahendiran; Jordi Asin-Cayuela; Frances H Blaikie; Abdul-Rahman B Manas; Carolyn M Porteous; Victoria J Adlam; Robin A J Smith; Michael P Murphy
Mitochondrial targeting of quinones: therapeutic implications.
Mitochondrion 2007;7 Suppl():S94-102.
2007: Andrew M James; Mark S Sharpley; Abdul-Rahman B Manas; Frank E Frerman; Judy Hirst; Robin A J Smith; Michael P Murphy
Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases.
The Journal of biological chemistry 2007;282(20):14708-18.
2007: Michael P Murphy; Robin A J Smith
Targeting antioxidants to mitochondria by conjugation to lipophilic cations.
Annual review of pharmacology and toxicology 2007;47():629-56.
2006: Meredith F Ross; Tatiana Da Ros; Frances H Blaikie; Tracy A Prime; Carolyn M Porteous; Inna I Severina; Vladimir P Skulachev; Henrik G Kjaergaard; Robin A J Smith; Michael P Murphy
Accumulation of lipophilic dications by mitochondria and cells.
The Biochemical journal 2006;400(1):199-208.
2006: Kristine M Robinson; Michael S Janes; Mariana Pehar; Jeffrey S Monette; Meredith F Ross; Tory M Hagen; Michael P Murphy; Joseph S Beckman
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15038-43.
2006: Aleksandra Filipovska; Michael P Murphy
Measurement of protein glutathionylation.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2006;Chapter 6():Unit6.11.
2006: Aleksandra Filipovska; Michael P Murphy
Overview of protein glutathionylation.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2006;Chapter 6():Unit6.10.
2006: Frances H Blaikie; Stephanie E Brown; Linda M Samuelsson; Martin D Brand; Robin A J Smith; Michael P Murphy
Targeting dinitrophenol to mitochondria: limitations to the development of a self-limiting mitochondrial protonophore.
Bioscience reports 2006;26(3):231-43.
2006: Matthew V Covey; Michael P Murphy; Catherine E Hobbs; Robin A J Smith; Dorothy E Oorschot
Effect of the mitochondrial antioxidant, Mito Vitamin E, on hypoxic-ischemic striatal injury in neonatal rats: a dose-response and stereological study.
Experimental neurology 2006;199(2):513-9.
2006: Christina C Dahm; Kevin Moore; Michael P Murphy
Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the interaction of nitric oxide with mitochondria.
The Journal of biological chemistry 2006;281(15):10056-65.
2005: Thomas R Hurd; Aleksandra Filipovska; Nikola J Costa; Christina C Dahm; Michael P Murphy
Disulphide formation on mitochondrial protein thiols.
Biochemical Society transactions 2005;33(Pt 6):1390-3.
2005: Andrew M James; Helena M Cochemé; Michael P Murphy
Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing.
Mechanisms of ageing and development 2005;126(9):982-6.
2005: Thomas R Hurd; Nikola J Costa; Christina C Dahm; Samantha M Beer; Stephanie E Brown; Aleksandra Filipovska; Michael P Murphy
Glutathionylation of mitochondrial proteins.
Antioxidants & redox signaling 2005;7(7-8):999-1010.
2005: Victoria J Adlam; Joanne C Harrison; Carolyn M Porteous; Andrew M James; Robin A J Smith; Michael P Murphy; Ivan A Sammut
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1088-95.
2005: Gillian Hughes; Michael P Murphy; Elizabeth C Ledgerwood
Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants.
The Biochemical journal 2005;389(Pt 1):83-9.
2005: Aleksandra Filipovska; Geoffrey F Kelso; Stephanie E Brown; Samantha M Beer; Robin A J Smith; Michael P Murphy
Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic. Insights into the interaction of ebselen with mitochondria.
The Journal of biological chemistry 2005;280(25):24113-26.
2005: Andrew M James; Helena M Cochemé; Robin A J Smith; Michael P Murphy
Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools.
The Journal of biological chemistry 2005;280(22):21295-312.
2005: Meredith F Ross; Geoffrey F Kelso; Frances H Blaikie; Andrew M James; Helena M Cochemé; Aleksandra Filipovska; T Da Ros; Thomas R Hurd; R A J Smith; Michael P Murphy
Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology.
Biochemistry. Biokhimii͡a 2005;70(2):222-30.
2004: Meredith F Ross; Michael P Murphy
Cell-penetrating peptides are excluded from the mitochondrial matrix.
Biochemical Society transactions 2004;32(Pt 6):1072-4.
2004: Michael P Murphy
Investigating mitochondrial radical production using targeted probes.
Biochemical Society transactions 2004;32(Pt 6):1011-4.
2004: Samantha M Beer; Ellen R Taylor; Stephanie E Brown; Christina C Dahm; Nikola J Costa; Michael J Runswick; Michael P Murphy
Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE.
The Journal of biological chemistry 2004;279(46):47939-51.
2004: Meredith F Ross; Aleksandra Filipovska; Robin A J Smith; Michael J Gait; Michael P Murphy
Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers.
The Biochemical journal 2004;383(Pt. 3):457-68.
2004: Jordi Asin-Cayuela; Abdul-Rahman B Manas; Andrew M James; Robin A J Smith; Michael P Murphy
Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant.
FEBS letters 2004;571(1-3):9-16.
2004: Andrew M James; Robin A J Smith; Michael P Murphy
Antioxidant and prooxidant properties of mitochondrial Coenzyme Q.
Archives of biochemistry and biophysics 2004;423(1):47-56.
2004: Katherine Green; Martin D Brand; Michael P Murphy
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes.
Diabetes 2004;53 Suppl 1():S110-8.
2004: Aleksandra Filipovska; Michael Eccles; Robin A J Smith; Michael P Murphy
Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation.
FEBS letters 2004;556(1-3):180-6.
2004: Martin D Brand; Julie A Buckingham; Telma C Esteves; Katherine Green; Adrian J Lambert; Satomi Miwa; Michael P Murphy; Julian L Pakay; Darren A Talbot; Karim S Echtay
Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production.
Biochemical Society symposium 2004;(71):203-13.
2004: Robin A J Smith; Geoffrey F Kelso; Andrew M James; Michael P Murphy
Targeting coenzyme Q derivatives to mitochondria.
Methods in enzymology 2004;382():45-67.
2003: Michael P Murphy; Karim S Echtay; Frances H Blaikie; Jordi Asin-Cayuela; Helena M Cocheme; Katherine Green; Julie A Buckingham; Ellen R Taylor; Fiona Hurrell; Gillian Hughes; Satomi Miwa; Chris E Cooper; Dimitri A Svistunenko; Robin A J Smith; Martin D Brand
Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone.
The Journal of biological chemistry 2003;278(49):48534-45.
2003: R A J Smith; Geoffrey F Kelso; Frances H Blaikie; Carolyn M Porteous; Elizabeth C Ledgerwood; Gillian Hughes; Andrew M James; Meredith F Ross; Jordi Asin-Cayuela; Helena M Cochemé; Aleksandra Filipovska; Michael P Murphy
Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences.
Biochemical Society transactions 2003;31(Pt 6):1295-9.
2003: Michael P Murphy
Does interplay between nitric oxide and mitochondria affect hypoxia-inducible transcription factor-1 activity?
The Biochemical journal 2003;376(Pt 2):e5-6.
2003: Andrew M James; Frances H Blaikie; Robin A J Smith; Robert N Lightowlers; Paul M Smith; Michael P Murphy
Specific targeting of a DNA-alkylating reagent to mitochondria. Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide.
European journal of biochemistry / FEBS 2003;270(13):2827-36.
2003: Nikola J Costa; Christina C Dahm; Fiona Hurrell; Ellen R Taylor; Michael P Murphy
Interactions of mitochondrial thiols with nitric oxide.
Antioxidants & redox signaling 2003;5(3):291-305.
2003: Ellen R Taylor; Fiona Hurrell; Richard J Shannon; Tsu-Kung Lin; Judy Hirst; Michael P Murphy
Reversible glutathionylation of complex I increases mitochondrial superoxide formation.
The Journal of biological chemistry 2003;278(22):19603-10.
2003: Robin A J Smith; Carolyn M Porteous; Alison M Gane; Michael P Murphy
Delivery of bioactive molecules to mitochondria in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5407-12.
2003: Gabriele Saretzki; Michael P Murphy; Thomas von Zglinicki
MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress.
Aging cell 2003;2(2):141-3.
2003: Kai He; Hitoshi Nukada; Teiji Urakami; Michael P Murphy
Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ): implications for its function in biological systems.
Biochemical pharmacology 2003;65(1):67-74.
2002: Karim S Echtay; Michael P Murphy; Robin A J Smith; Darren A Talbot; Martin D Brand
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants.
The Journal of biological chemistry 2002;277(49):47129-35.
2002: Tsu-Kung Lin; Gillian Hughes; Aleksandra Muratovska; Frances H Blaikie; Paul S Brookes; Victor Darley-Usmar; Robin A J Smith; Michael P Murphy
Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach.
The Journal of biological chemistry 2002;277(19):17048-56.
2002: Geoffrey F Kelso; Carolyn M Porteous; Gillian Hughes; Elizabeth C Ledgerwood; Alison M Gane; Robin A J Smith; Michael P Murphy
Prevention of mitochondrial oxidative damage using targeted antioxidants.
Annals of the New York Academy of Sciences 2002;959():263-74.
2001: Michael P Murphy
Development of lipophilic cations as therapies for disorders due to mitochondrial dysfunction.
Expert opinion on biological therapy 2001;1(5):753-64.
2001: S M Davies; Anne Poljak; Mark W Duncan; G A Smythe; Michael P Murphy
Measurements of protein carbonyls, ortho- and meta-tyrosine and oxidative phosphorylation complex activity in mitochondria from young and old rats.
Free radical biology & medicine 2001;31(2):181-90.
2001: Aleksandra Muratovska; Robert N Lightowlers; Robert W Taylor; Jackie Wilce; Michael P Murphy
Targeting large molecules to mitochondria.
Advanced drug delivery reviews 2001;49(1-2):189-98.
2001: Robert W Taylor; Theresa M Wardell; Paul M Smith; Aleksandra Muratovska; Michael P Murphy; Douglass M Turnbull; Robert N Lightowlers
An antigenomic strategy for treating heteroplasmic mtDNA disorders.
Advanced drug delivery reviews 2001;49(1-2):121-5.
2001: Aleksandra Muratovska; Robert N Lightowlers; Robert W Taylor; Douglass M Turnbull; Robin A J Smith; Jackie Wilce; S W Martin; Michael P Murphy
Targeting peptide nucleic acid (PNA) oligomers to mitochondria within cells by conjugation to lipophilic cations: implications for mitochondrial DNA replication, expression and disease.
Nucleic acids research 2001;29(9):1852-63.
2001: Michael P Murphy
How understanding the control of energy metabolism can help investigation of mitochondrial dysfunction, regulation and pharmacology.
Biochimica et biophysica acta 2001;1504(1):1-11.
2001: Geoffrey F Kelso; Carolyn M Porteous; CV Coulter; Gillian Hughes; WK Porteous; Elizabeth C Ledgerwood; Robin A J Smith; Michael P Murphy
Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties.
The Journal of biological chemistry 2001;276(7):4588-96.
2000: J L Scarlett; Philip W Sheard; Gillian Hughes; Elizabeth C Ledgerwood; H H Ku; Michael P Murphy
Changes in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cells.
FEBS letters 2000;475(3):267-72.
2000: CV Coulter; Geoffrey F Kelso; T K Lin; Robin A J Smith; Michael P Murphy
Mitochondrially targeted antioxidants and thiol reagents.
Free radical biology & medicine 2000;28(10):1547-54.
2000: Michael P Murphy; R A Smith
Drug delivery to mitochondria: the key to mitochondrial medicine.
Advanced drug delivery reviews 2000;41(2):235-50.
1999: Robin A J Smith; Carolyn M Porteous; CV Coulter; Michael P Murphy
Selective targeting of an antioxidant to mitochondria.
European journal of biochemistry / FEBS 1999;263(3):709-16.
1999: Michael P Murphy
Nitric oxide and cell death.
Biochimica et biophysica acta 1999;1411(2-3):401-14.
1999: RD Appleby; WK Porteous; Gillian Hughes; Andrew M James; D Shannon; YH Wei; Michael P Murphy
Quantitation and origin of the mitochondrial membrane potential in human cells lacking mitochondrial DNA.
European journal of biochemistry / FEBS 1999;262(1):108-16.
1999: K He; Hitoshi Nukada; P Denise McMorran; Michael P Murphy
Protein carbonyl formation and tyrosine nitration as markers of oxidative damage during ischaemia-reperfusion injury to rat sciatic nerve.
Neuroscience 1999;94(3):909-16.
1999: Andrew M James; Philip W Sheard; YH Wei; Michael P Murphy
Decreased ATP synthesis is phenotypically expressed during increased energy demand in fibroblasts containing mitochondrial tRNA mutations.
European journal of biochemistry / FEBS 1999;259(1-2):462-9.
1998: WK Porteous; Andrew M James; Philip W Sheard; Carolyn M Porteous; M A Packer; S J Hyslop; J V Melton; Cheng-Yoong Pang; YH Wei; Michael P Murphy
Bioenergetic consequences of accumulating the common 4977-bp mitochondrial DNA deletion.
European journal of biochemistry / FEBS 1998;257(1):192-201.
1998: Michael P Murphy; M A Packer; J L Scarlett; S W Martin
Peroxynitrite: a biologically significant oxidant.
General pharmacology 1998;31(2):179-86.
1997: J L Scarlett; Michael P Murphy
Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transition.
FEBS letters 1997;418(3):282-6.
1997: M A Packer; J L Scarlett; S W Martin; Michael P Murphy
Induction of the mitochondrial permeability transition by peroxynitrite.
Biochemical Society transactions 1997;25(3):909-14.
1997: S J Hyslop; Andrew M James; Marion A Maw; N Fischel-Ghodsian; Michael P Murphy
The effect on mitochondrial function of the tRNA Ser(UCN)/COI A7445G mtDNA point mutation associated with maternally-inherited sensorineural deafness.
Biochemistry and molecular biology international 1997;42(3):567-75.
1997: R J Burns; Michael P Murphy
Labeling of mitochondrial proteins in living cells by the thiol probe thiobutyltriphenylphosphonium bromide.
Archives of biochemistry and biophysics 1997;339(1):33-9.
1996: J L Scarlett; M A Packer; Carolyn M Porteous; Michael P Murphy
Alterations to glutathione and nicotinamide nucleotides during the mitochondrial permeability transition induced by peroxynitrite.
Biochemical pharmacology 1996;52(7):1047-55.
1996: M A Packer; Carolyn M Porteous; Michael P Murphy
Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite.
Biochemistry and molecular biology international 1996;40(3):527-34.
1996: Andrew M James; Y H Wei; Cheng-Yoong Pang; Michael P Murphy
Altered mitochondrial function in fibroblasts containing MELAS or MERRF mitochondrial DNA mutations.
The Biochemical journal 1996;318 ( Pt 2)():401-7.
1996: R Miesel; Michael P Murphy; H Kröger
Enhanced mitochondrial radical production in patients which rheumatoid arthritis correlates with elevated levels of tumor necrosis factor alpha in plasma.
Free radical research 1996;25(2):161-9.
1996: M A Packer; R Miesel; Michael P Murphy
Exposure to the parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP+) and nitric oxide simultaneously causes cyclosporin A-sensitive mitochondrial calcium efflux and depolarisation.
Biochemical pharmacology 1996;51(3):267-73.
1995: M A Packer; Michael P Murphy
Peroxynitrite formed by simultaneous nitric oxide and superoxide generation causes cyclosporin-A-sensitive mitochondrial calcium efflux and depolarisation.
European journal of biochemistry / FEBS 1995;234(1):231-9.
1995: Michael P Murphy; M J Krueger; SO Sablin; Rona R Ramsay; T P Singer
Inhibition of complex I by hydrophobic analogues of N-methyl-4-phenylpyridinium (MPP+) and the use of an ion-selective electrode to measure their accumulation by mitochondria and electron-transport particles.
The Biochemical journal 1995;306 ( Pt 2)():359-65.
1994: M A Packer; Michael P Murphy
Peroxynitrite causes calcium efflux from mitochondria which is prevented by Cyclosporin A.
FEBS letters 1994;345(2-3):237-40.
1994: N Reichman; Carolyn M Porteous; Michael P Murphy
Cyclosporin A blocks 6-hydroxydopamine-induced efflux of Ca2+ from mitochondria without inactivating the mitochondrial inner-membrane pore.
The Biochemical journal 1994;297 ( Pt 1)():151-5.