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James Murray

Research Profile

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Drug Design

Anatomy

Tumor Cell Line

Chemicals & Drugs

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Molecular Structure

Physiology

Cell Proliferation

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Publications

TOP 3
Alba T Macias; Nicola Allen; Jenifer Borgognoni; Alexandra Clay; Zoe Daniels; Pawel Dokurno; Martin J Drysdale; Geraint L Francis; Christopher J Graham; Rob Howes; Natalia Matassova; James B Murray; Rachel Parsons; Terry Shaw; Allan E Surgenor; Lindsey Terry; Yikang Wang; Douglas S Williamson; Mike Wood; Andrew James Massey
Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
Andrew Potter; Victoria Oldfield; Claire Nunns; Christophe Fromont; Stuart Ray; Christopher J Northfield; Christopher J Bryant; Simon F Scrace; David Robinson; Natalia Matossova; Lisa Baker; Pawel Dokurno; Allan Surgenor; Ben Davis; Christine M Richardson; James B Murray; Jonathan D Moore
Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution.
Andrew James Massey; Douglas S Williamson; Helen Browne; James B Murray; Pawel Dokurno; Terry Shaw; Alba T Macias; Zoe Daniels; Stephanie Geoffroy; Melanie Dopson; Paul Lavan; Natalia Matassova; Geraint L Francis; Christopher J Graham; Rachel Parsons; Yikang Wang; Antony Padfield; Mike Comer; Martin J Drysdale; Mike Wood
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

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All Publications

2011: Alba T Macias; Nicola Allen; Jenifer Borgognoni; Alexandra Clay; Zoe Daniels; Pawel Dokurno; Martin J Drysdale; Geraint L Francis; Christopher J Graham; Rob Howes; Natalia Matassova; James B Murray; Rachel Parsons; Terry Shaw; Allan E Surgenor; Lindsey Terry; Yikang Wang; Douglas S Williamson; Mike Wood; Andrew James Massey
Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
Journal of medicinal chemistry 2011;54(12):4034-41.
2010: Andrew Potter; Victoria Oldfield; Claire Nunns; Christophe Fromont; Stuart Ray; Christopher J Northfield; Christopher J Bryant; Simon F Scrace; David Robinson; Natalia Matossova; Lisa Baker; Pawel Dokurno; Allan Surgenor; Ben Davis; Christine M Richardson; James B Murray; Jonathan D Moore
Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution.
Bioorganic & medicinal chemistry letters 2010;20(22):6483-8.
2010: Andrew James Massey; Douglas S Williamson; Helen Browne; James B Murray; Pawel Dokurno; Terry Shaw; Alba T Macias; Zoe Daniels; Stephanie Geoffroy; Melanie Dopson; Paul Lavan; Natalia Matassova; Geraint L Francis; Christopher J Graham; Rachel Parsons; Yikang Wang; Antony Padfield; Mike Comer; Martin J Drysdale; Mike Wood
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.
Cancer chemotherapy and pharmacology 2010;66(3):535-45.
2010: Andrew J Potter; Stuart Ray; Louisa Gueritz; Claire L Nunns; Christopher J Bryant; Simon F Scrace; Natalia Matassova; Lisa Baker; Pawel Dokurno; David A Robinson; Allan Surgenor; Ben Davis; James B Murray; Christine M Richardson; Jonathan D Moore
Structure-guided design of alpha-amino acid-derived Pin1 inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(2):586-90.
2009: Douglas S Williamson; Jenifer Borgognoni; Alexandra Clay; Zoe Daniels; Pawel Dokurno; Martin J Drysdale; Nicolas Foloppe; Geraint L Francis; Christopher J Graham; Rob Howes; Alba T Macias; James B Murray; Rachel Parsons; Terry Shaw; Allan E Surgenor; Lindsey Terry; Yikang Wang; Mike Wood; Andrew James Massey
Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
Journal of medicinal chemistry 2009;52(6):1510-3.
2007: Christine M Richardson; Claire L Nunns; Douglas Williamson; Martin J Parratt; Pawel Dokurno; Rob Howes; Jenifer Borgognoni; Martin J Drysdale; Harry Finch; Roderick E Hubbard; Philip S Jackson; Peter Kierstan; Georg Lentzen; Jonathan D Moore; James B Murray; Heather Simmonite; Allan Surgenor; Christopher J Torrance
Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.
Bioorganic & medicinal chemistry letters 2007;17(14):3880-5.
2006: Christine M Richardson; Douglas Williamson; Martin J Parratt; Jenifer Borgognoni; Andrew D Cansfield; Pawel Dokurno; Geraint L Francis; Rob Howes; Jonathan D Moore; James B Murray; Alan Robertson; Allan Surgenor; Christopher J Torrance
Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.
Bioorganic & medicinal chemistry letters 2006;16(5):1353-7.
2006: James B Murray; Samy O Meroueh; Rupert J M Russell; Georg Lentzen; Jalal Haddad; Shahriar Mobashery
Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site.
Chemistry & biology 2006;13(2):129-38.
2005: Douglas Williamson; Martin J Parratt; Justin F Bower; Jonathan D Moore; Christine M Richardson; Pawel Dokurno; Andrew D Cansfield; Geraint L Francis; Richard Hebdon; Rob Howes; Philip S Jackson; Andrea M Lockie; James B Murray; Claire L Nunns; Jenifer Powles; Alan Robertson; Allan Surgenor; Christopher J Torrance
Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.
Bioorganic & medicinal chemistry letters 2005;15(4):863-7.
2003: Rupert J M Russell; James B Murray; Georg Lentzen; Jalal Haddad; Shahriar Mobashery
The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography.
Journal of the American Chemical Society 2003;125(12):3410-1.