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Frederick Beland

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Igor P Pogribny; Svitlana Shpyleva; Gordon Surratt; Volodymyr Tryndyak; Gonçalo Gamboa da Costa; Marta Pogribna; Frederick A Beland
Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents.
Igor Koturbash; Stepan Melnyk; Frederick A Beland; S Jill James; Igor P Pogribny
Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.
Qiangen Wu; Frederick A Beland; Ching-Wei Chang; Jia-Long Fang
Role of DNA Repair Pathways in Response to Zidovudine-induced DNA Damage in Immortalized Human Liver THLE2 Cells.

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2013: Igor P Pogribny; Svitlana Shpyleva; Gordon Surratt; Volodymyr Tryndyak; Gonçalo Gamboa da Costa; Marta Pogribna; Frederick A Beland
Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents.
International journal of oncology 2013;42(5):1822-32.
2013: Igor Koturbash; Stepan Melnyk; Frederick A Beland; S Jill James; Igor P Pogribny
Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.
Molecular carcinogenesis 2013;52(4):318-27.
2013: Qiangen Wu; Frederick A Beland; Ching-Wei Chang; Jia-Long Fang
Role of DNA Repair Pathways in Response to Zidovudine-induced DNA Damage in Immortalized Human Liver THLE2 Cells.
International journal of biomedical science : IJBS 2013;9(1):18-25.
2013: Alexandra M M Antunes; Frederick A Beland; M Conceição Oliveira; Benjamin Wolf; M Matilde Marques
2'-Deoxythymidine Adducts from the Anti-HIV Drug Nevirapine.
Molecules (Basel, Switzerland) 2013;18(5):4955-71.
2013: Frederick A Beland; M Matilde Marques; Paul W Mellick; Maria C B Mendoza; Greg R Olson; Daniel R Doerge
Carcinogenicity of acrylamide in B6C3F(1) mice and F344/N rats from a 2-year drinking water exposure.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013;51():149-59.
2013: Mary D Boudreau; Robert P Felton; Paul W Mellick; Greg R Olson; Brett T Thorn; Frederick A Beland
Clear evidence of carcinogenic activity by a whole-leaf extract of Aloe barbadensis miller (aloe vera) in F344/N rats.
Toxicological sciences : an official journal of the Society of Toxicology 2013;131(1):26-39.
2012: Volodymyr Tryndyak; Sharon A Ross; Ivan Rusyn; Svitlana Shymonyak; Frederick A Beland; Leonard Collins; Aline de Conti; James C Fuscoe; Tao Han; Tetyana Kobets; Igor Koturbash; Kristy Kutanzi; John R Latendresse; Stepan Melnyk; Igor P Pogribny
Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(11):4592-602.
2012: Kaarthik John; Gail McMullen; Ofelia A Olivero; Igor P Pogribny; Frederick A Beland; Mona I Churchwell; M Margaret Pratt; Miriam C Poirier
Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days.
Carcinogenesis 2012;33(11):2236-41.
2012: Linda S Von Tungeln; William M Witt; Daniel R Doerge; Gonçalo Gamboa da Costa; Igor Koturbash; M Matilde Marques; Igor P Pogribny; Frederick A Beland
Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.
International journal of cancer. Journal international du cancer 2012;131(9):2008-15.
2012: Robert N McBurney; Carrie L Moland; Nicole M Morel; Thomas N Plasterer; Laura K Schnackenberg; Zhenqiang Su; Edward J Takach; Weida Tong; Linda S VonTungeln; Chenhui Zeng; Shelagh A Booth; Jennifer M Campbell; Ching-Wei Chang; James J Chen; Paul L Courchesne; Xiao-hui Fan; James C Fuscoe; Armin Graber; Yu Guo; Tao Han; Wade M Hines; Peter Juhasz; Tricia Y Li; Moira D Lynch; Raji Balasubramanian; Richard D Beger; Frederick A Beland
The liver toxicity biomarker study phase I: markers for the effects of tolcapone or entacapone.
Toxicologic pathology 2012;40(6):951-64.
2012: Gonçalo Gamboa da Costa; Nicholas R Hasbrouck; David G Hattan; Cristina C Jacob; Greg R Olson; renate reimschuessel; Linda S Von Tungeln; Frederick A Beland
Dose-response assessment of nephrotoxicity from a twenty-eight-day combined-exposure to melamine and cyanuric acid in F344 rats.
Toxicology and applied pharmacology 2012;262(2):99-106.
2012: Volodymyr Tryndyak; Sharon A Ross; Ivan Rusyn; Frederick A Beland; John R Latendresse; Beverly Montgomery; Igor P Pogribny
Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet.
Toxicology and applied pharmacology 2012;262(1):52-9.
2012: Natalie E Simpson; Volodymyr P Tryndyak; Frederick A Beland; Igor P Pogribny
An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression.
Breast cancer research and treatment 2012;133(3):959-68.
2012: Cristina C Jacob; Michelle Vanlandingham; Linda S Von Tungeln; Frederick A Beland; Gonçalo Gamboa da Costa
Pharmacokinetics of melamine and cyanuric acid and their combinations in F344 rats.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(2):317-24.
2012: Hsiu-Mei Chiang; Frederick A Beland; Paul C Howard; Barbara J Miller; Cheng Wang; Shuguang Wang; Qingsu Xia; Jun Jie Yin; Hongtao Yu; Xiaoju Zou; Peter P Fu
Nanoscale ZnO induces cytotoxicity and DNA damage in human cell lines and rat primary neuronal cells.
Journal of nanoscience and nanotechnology 2012;12(3):2126-35.
2012: Alexandra M M Antunes; Frederick A Beland; João L Ferreira da Silva; Shrika G Harjivan; David A Novais; Pedro P Santos; Muna Sidarus; M Matilde Marques
Oxidation of 2-hydroxynevirapine, a phenolic metabolite of the anti-HIV drug nevirapine: evidence for an unusual pyridine ring contraction.
Molecules (Basel, Switzerland) 2012;17(3):2616-27.
2011: Alexandra M M Antunes; Frederick A Beland; David A Novais; Pedro P Santos; J L Ferreira da Silva; M Conceição Oliveira; M Matilde Marques
Synthesis and oxidation of 2-hydroxynevirapine, a metabolite of the HIV reverse transcriptase inhibitor nevirapine.
Organic & biomolecular chemistry 2011;9(22):7822-35.
2011: Luísa Camacho; Frederick A Beland; Kevin P Kelly; Gonçalo Gamboa da Costa
Gene expression of biomarkers of nephrotoxicity in F344 rats co-exposed to melamine and cyanuric acid for seven days.
Toxicology letters 2011;206(2):166-71.
2011: Svitlana I Shpyleva; Erik J Tokar; Volodymyr Tryndyak; Michael P Waalkes; Frederick A Beland; Igor Koturbash; Levan Muskhelishvili; Igor P Pogribny
Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver.
Toxicological sciences : an official journal of the Society of Toxicology 2011;123(2):433-40.
2011: Linda S Von Tungeln; Kellie A Woodling; Tong Zhou; Daniel R Doerge; Kevin J Greenlees; Frederick A Beland
Benzocaine-induced methemoglobinemia in an acute-exposure rat model.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011;49(10):2530-5.
2011: Igor Koturbash; Fernando Pardo-Manuel Devillena; Frederick A Beland; Wanda Bodnar; Ivan Rusyn; Anne Scherhag; Kenneth Sexton; Jessica Sorrentino; James A Swenberg; Igor P Pogribny
Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene.
Toxicological sciences : an official journal of the Society of Toxicology 2011;122(2):448-56.
2011: Igor P Pogribny; Levan Muskhelishvili; Volodymyr Tryndyak; Frederick A Beland
The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluorene.
Mutation research 2011;722(2):106-13.
2011: Igor Koturbash; Frederick A Beland; Igor P Pogribny
Role of epigenetic events in chemical carcinogenesis--a justification for incorporating epigenetic evaluations in cancer risk assessment.
Toxicology mechanisms and methods 2011;21(4):289-97.
2011: Igor Koturbash; Anne Scherhag; Jessica Sorrentino; Kenneth Sexton; Wanda Bodnar; Volodymyr Tryndyak; John R Latendresse; James A Swenberg; Frederick A Beland; Igor P Pogribny; Ivan Rusyn
Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene.
Environmental health perspectives 2011;119(5):635-40.
2011: Qiangen Wu; Frederick A Beland; Ching-Wei Chang; Jia-Long Fang
XPC is essential for nucleotide excision repair of zidovudine-induced DNA damage in human hepatoma cells.
Toxicology and applied pharmacology 2011;251(2):155-62.
2011: Volodymyr Tryndyak; Tao Han; Levan Muskhelishvili; James C Fuscoe; Sharon A Ross; Frederick A Beland; Igor P Pogribny
Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet.
Molecular nutrition & food research 2011;55(3):411-8.
2011: Cristina C Jacob; renate reimschuessel; Linda S Von Tungeln; Greg R Olson; Alan Warbritton; David G Hattan; Frederick A Beland; Gonçalo Gamboa da Costa
Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(2):391-7.
2011: Svitlana I Shpyleva; Volodymyr P Tryndyak; Olga Kovalchuk; Athena Starlard-Davenport; Vasy' F Chekhun; Frederick A Beland; Igor P Pogribny
Role of ferritin alterations in human breast cancer cells.
Breast cancer research and treatment 2011;126(1):63-71.
2011: Ching-Wei Chang; James C Fuscoe; Tao Han; Wade M Hines; Frederick A Beland; James J Chen
Identification and categorization of liver toxicity markers induced by a related pair of drugs.
International journal of molecular sciences 2011;12(7):4609-24.
2010: Alexandra M M Antunes; Ana L A Godinho; Inês L Martins; M Conceição Oliveira; Ricardo A Gomes; Ana V Coelho; Frederick A Beland; M Matilde Marques
Protein adducts as prospective biomarkers of nevirapine toxicity.
Chemical research in toxicology 2010;23(11):1714-25.
2010: Igor P Pogribny; Athena Starlard-Davenport; Volodymyr Tryndyak; Tao Han; Sharon A Ross; Ivan Rusyn; Frederick A Beland
Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice.
Laboratory investigation; a journal of technical methods and pathology 2010;90(10):1437-46.
2010: A Starlard-Davenport; B Lyn-Cook; Frederick A Beland; Igor P Pogribny
The role of UDP-glucuronosyltransferases and drug transporters in breast cancer drug resistance.
Experimental oncology 2010;32(3):172-80.
2010: Jia-Long Fang; Robin L Stingley; Frederick A Beland; Wafa Harrouk; Debbie L Lumpkins; Paul Howard
Occurrence, efficacy, metabolism, and toxicity of triclosan.
Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews 2010;28(3):147-71.
2010: Volodymyr P Tryndyak; Frederick A Beland; Igor P Pogribny
E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells.
International journal of cancer. Journal international du cancer 2010;126(11):2575-83.
2010: Alexandra M M Antunes; Ana L A Godinho; Inês L Martins; Gonçalo Justino; Frederick A Beland; M Matilde Marques
Amino acid adduct formation by the nevirapine metabolite, 12-hydroxynevirapine--a possible factor in nevirapine toxicity.
Chemical research in toxicology 2010;23(5):888-99.
2010: Peter P Fu; Ming W Chou; Mona I Churchwell; Yuping Wang; Yuewei Zhao; Qingsu Xia; Gonçalo Gamboa da Costa; M Matilde Marques; Frederick A Beland; Daniel R Doerge
High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of pyrrolizidine alkaloid-derived DNA adducts in vitro and in vivo.
Chemical research in toxicology 2010;23(3):637-52.
2010: Athena Starlard-Davenport; Volodymyr Tryndyak; Smitha R James; Adam R Karpf; John R Latendresse; Frederick A Beland; Igor P Pogribny
Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats.
Carcinogenesis 2010;31(3):376-81.
2010: Athena Starlard-Davenport; Volodymyr Tryndyak; Oksana Kosyk; Sharon R Ross; Ivan Rusyn; Frederick A Beland; Igor P Pogribny
Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.
Journal of nutrigenetics and nutrigenomics 2010;3(4-6):259-66.
2010: Athena Starlard-Davenport; Volodymyr Tryndyak; Oksana Kosyk; Sharon R Ross; Ivan Rusyn; Frederick A Beland; Igor P Pogribny
Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.
World review of nutrition and dietetics 2010;101():123-30.
2009: Igor P Pogribny; Svitlana I Shpyleva; Levan Muskhelishvili; Tetyana V Bagnyukova; S Jill James; Frederick A Beland
Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet.
Mutation research 2009;669(1-2):56-62.
2009: Jia-Long Fang; Frederick A Beland
Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2009;111(1):120-30.
2009: Igor P Pogribny; Volodymyr Tryndyak; Tetyana V Bagnyukova; Stepan Melnyk; Beverly Montgomery; Sharon A Ross; John R Latendresse; Ivan Rusyn; Frederick A Beland
Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.
Journal of hepatology 2009;51(1):176-86.
2009: Igor P Pogribny; Frederick A Beland
DNA hypomethylation in the origin and pathogenesis of human diseases.
Cellular and molecular life sciences : CMLS 2009;66(14):2249-61.
2009: Volodymyr Tryndyak; Sharon A Ross; Frederick A Beland; Igor P Pogribny
Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet.
Molecular carcinogenesis 2009;48(6):479-87.
2009: Linda S Von Tungeln; Mona I Churchwell; Daniel R Doerge; Joseph G Shaddock; Lynda J McGarrity; Robert H Heflich; Gonçalo Gamboa da Costa; M Matilde Marques; Frederick A Beland
DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide.
International journal of cancer. Journal international du cancer 2009;124(9):2006-15.
2009: Igor P Pogribny; Levan Muskhelishvili; Volodymyr Tryndyak; Frederick A Beland
The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation.
Toxicology and applied pharmacology 2009;235(3):305-11.
2009: Varsha G Desai; Taewon Lee; Carrie L Moland; William S Branham; Linda S Von Tungeln; Frederick A Beland; James C Fuscoe
Effect of short-term exposure to zidovudine (AZT) on the expression of mitochondria-related genes in skeletal muscle of neonatal mice.
Mitochondrion 2009;9(1):9-16.
2008: Tetyana V Bagnyukova; Volodymyr Tryndyak; Levan Muskhelishvili; Sharon A Ross; Frederick A Beland; Igor P Pogribny
Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats.
Cell cycle (Georgetown, Tex.) 2008;7(20):3202-10.
2008: Igor P Pogribny; Volodymyr Tryndyak; Sharon A Ross; Frederick A Beland
Differential expression of microRNAs during hepatocarcinogenesis induced by methyl deficiency in rats.
Nutrition reviews 2008;66 Suppl 1():S33-5.
2008: Alexandra M M Antunes; Mariana P Duarte; Pedro P Santos; Gonçalo Gamboa da Costa; Thomas Heinze; Frederick A Beland; M Matilde Marques
Synthesis and characterization of DNA adducts from the HIV reverse transcriptase inhibitor nevirapine.
Chemical research in toxicology 2008;21(7):1443-56.
2008: Danuta Malejka-Giganti; Daniel R Parkin; Richard W Decker; Gloria A Niehans; Robin L Bliss; Mona I Churchwell; Frederick A Beland
Tumorigenicity and genotoxicity of an environmental pollutant 2,7-dinitrofluorene after systemic administration at a low dose level to female rats.
International journal of cancer. Journal international du cancer 2008;122(9):1958-65.
2008: Tetyana V Bagnyukova; Volodymyr Tryndyak; Beverly Montgomery; Mona I Churchwell; Adam R Karpf; Smitha R James; Levan Muskhelishvili; Frederick A Beland; Igor P Pogribny
Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene.
Carcinogenesis 2008;29(3):638-46.
2008: Igor P Pogribny; Ivan Rusyn; Frederick A Beland
Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents.
Environmental and molecular mutagenesis 2008;49(1):9-15.
2007: Gonçalo Gamboa da Costa; M Matilde Marques; Xin Fu; Mona I Churchwell; Yu-Ping Wang; Daniel R Doerge; Frederick A Beland
Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen.
Cancer letters 2007;257(2):191-8.
2007: Igor P Pogribny; Tetyana V Bagnyukova; Volodymyr Tryndyak; Levan Muskhelishvili; Rocio Rodriguez-Juarez; Olga Kovalchuk; Tao Han; James C Fuscoe; Sharon A Ross; Frederick A Beland
Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis.
Toxicology and applied pharmacology 2007;225(1):61-9.
2007: Olga Kovalchuk; Volodymyr Tryndyak; Beverly Montgomery; Alexander Boyko; Kristy Kutanzi; Franz Zemp; Alan Warbritton; John R Latendresse; Igor Kovalchuk; Frederick A Beland; Igor P Pogribny
Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression.
Cell cycle (Georgetown, Tex.) 2007;6(16):2010-8.
2007: Igor P Pogribny; Volodymyr Tryndyak; Alexander Boyko; Rocio Rodriguez-Juarez; Frederick A Beland; Olga Kovalchuk
Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure.
Mutation research 2007;619(1-2):30-7.
2007: Linda S Von Tungeln; Lee D Williams; Daniel R Doerge; Joseph G Shaddock; Lynda J McGarrity; Suzanne M Morris; Roberta A Mittelstaedt; Robert H Heflich; Frederick A Beland
Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine.
Environmental and molecular mutagenesis 2007;48(3-4):258-69.
2007: Volodymyr Tryndyak; Olga Kovalchuk; Levan Muskhelishvili; Beverly Montgomery; Rocio Rodriguez-Juarez; Stepan Melnyk; Sharon A Ross; Frederick A Beland; Igor P Pogribny
Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis.
Molecular carcinogenesis 2007;46(3):187-97.
2007: Gonçalo Gamboa da Costa; Pedro C Pereira; Mona I Churchwell; Frederick A Beland; M Matilde Marques
DNA adduct formation in the livers of female Sprague-Dawley rats treated with toremifene or alpha-hydroxytoremifene.
Chemical research in toxicology 2007;20(2):300-10.
2007: Célia Martins; Nuno G Oliveira; Marta Pingarilho; Gonçalo Gamboa da Costa; Vanda Martins; M Matilde Marques; Frederick A Beland; Mona I Churchwell; Daniel R Doerge; Jose Rueff; Jorge Gaspar
Cytogenetic damage induced by acrylamide and glycidamide in mammalian cells: correlation with specific glycidamide-DNA adducts.
Toxicological sciences : an official journal of the Society of Toxicology 2007;95(2):383-90.
2006: Mona I Churchwell; Frederick A Beland; Daniel R Doerge
Quantification of O6-methyl and O6-ethyl deoxyguanosine adducts in C57BL/6N/Tk+/- mice using LC/MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;844(1):60-6.
2006: Volodymyr Tryndyak; Levan Muskhelishvili; Olga Kovalchuk; Rocio Rodriguez-Juarez; Beverly Montgomery; Mona I Churchwell; Sharon A Ross; Frederick A Beland; Igor P Pogribny
Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis.
Carcinogenesis 2006;27(8):1713-20.
2006: Sandra J Culp; Paul W Mellick; Ronald W Trotter; Kevin J Greenlees; Ralph L Kodell; Frederick A Beland
Carcinogenicity of malachite green chloride and leucomalachite green in B6C3F1 mice and F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(8):1204-12.
2006: Mary D Boudreau; Frederick A Beland
An evaluation of the biological and toxicological properties of Aloe barbadensis (miller), Aloe vera.
Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews 2006;24(1):103-54.
2006: Barbara L Parsons; Robert R Delongchamp; Frederick A Beland; Robert H Heflich
Levels of H-ras codon 61 CAA to AAA mutation: response to 4-ABP-treatment and Pms2-deficiency.
Mutagenesis 2006;21(1):29-34.
2005: Tao Chen; Roberta A Mittelstaedt; Frederick A Beland; Robert H Heflich; Martha M Moore; Barbara L Parsons
4-Aminobiphenyl induces liver DNA adducts in both neonatal and adult mice but induces liver mutations only in neonatal mice.
International journal of cancer. Journal international du cancer 2005;117(2):182-7.
2005: Frederick A Beland; M Matilde Marques; Gonçalo Gamboa da Costa; David H Phillips
Tamoxifen-DNA adduct formation in human endometrium.
Chemical research in toxicology 2005;18(10):1507-9; author reply 1509-11.
2005: Frederick A Beland; Mona I Churchwell; Linda S Von Tungeln; Shoujun Chen; Peter P Fu; Sandra J Culp; Bernadette Schoket; Erika Gyorffy; János Minárovits; Miriam C Poirier; Elise D Bowman; Ainsley Weston; Daniel R Doerge
High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of benzo[a]pyrene-DNA adducts.
Chemical research in toxicology 2005;18(8):1306-15.
2005: Barbara L Parsons; Frederick A Beland; Linda S Von Tungeln; Robert R Delongchamp; Peter P Fu; Robert H Heflich
Levels of 4-aminobiphenyl-induced somatic H-ras mutation in mouse liver DNA correlate with potential for liver tumor development.
Molecular carcinogenesis 2005;42(4):193-201.
2005: Laura J Schild; David H Phillips; Martin R Osborne; Alan Hewer; Frederick A Beland; Mona I Churchwell; Karen Brown; Margaret Gaskell; Elizabeth Wright; Miriam C Poirier
Hepatic DNA adduct dosimetry in rats fed tamoxifen: a comparison of methods.
Mutagenesis 2005;20(2):115-24.
2005: Vasily N Dobrovolsky; Lynda J McGarrity; Linda S VonTungeln; Roberta A Mittelstaedt; Suzanne M Morris; Frederick A Beland; Robert H Heflich
Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/- and Tk-/- mice.
Mutation research 2005;570(2):227-35.
2005: Daniel R Doerge; Gonçalo Gamboa da Costa; L Patrice McDaniel; Mona I Churchwell; Nathan C Twaddle; Frederick A Beland
DNA adducts derived from administration of acrylamide and glycidamide to mice and rats.
Mutation research 2005;580(1-2):131-41.
2005: Danuta Malejka-Giganti; Kristen K Bennett; Sandra J Culp; Frederick A Beland; Hisashi Shinozuka; Robin L Bliss
Suppression of 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis by pre-initiation treatment of rats with beta-naphthoflavone coincides with decreased levels of the carcinogen-derived DNA adducts in the mammary gland.
Cancer detection and prevention 2005;29(4):338-47.
2005: Frederick A Beland; R Wayne Benson; Paul W Mellick; Robert M Kovatch; Dean W Roberts; Jia-Long Fang; Daniel R Doerge
Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(1):1-19.
2004: Frederick A Beland; Mona I Churchwell; Alan Hewer; David H Phillips; Gonçalo Gamboa da Costa; M Matilde Marques
Analysis of tamoxifen-DNA adducts in endometrial explants by MS and 32P-postlabeling.
Biochemical and biophysical research communications 2004;320(2):297-302.
2004: Frederick A Beland; Mona I Churchwell; Daniel R Doerge; Daniel R Parkin; Danuta Malejka-Giganti; Alan Hewer; David H Phillips; Carmichael Paul; Gonçalo Gamboa da Costa; M Matilde Marques
Electrospray ionization-tandem mass spectrometry and 32P-postlabeling analyses of tamoxifen-DNA adducts in humans.
Journal of the National Cancer Institute 2004;96(14):1099-104.
2004: Roberta A Mittelstaedt; Nan Mei; Peggy J Webb; Joseph G Shaddock; Vasily N Dobrovolsky; Lynda J McGarrity; Suzanne M Morris; Tao Chen; Frederick A Beland; Kevin J Greenlees; Robert H Heflich
Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice.
Mutation research 2004;561(1-2):127-38.
2004: Linda S Von Tungeln; Vasily N Dobrovolsky; Michelle E Bishop; Joseph G Shaddock; Robert H Heflich; Frederick A Beland
Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in mice treated neonatally with zidovudine and didanosine.
Mutagenesis 2004;19(4):307-11.
2004: Ming W Chou; Jian Yan; Jasyl Nichols; Qingsu Xia; Frederick A Beland; Po C Chan; Peter P Fu
Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F1 mice [Cancer Lett. 193 (2003) 119-125.
Cancer letters 2004;207(1):119-25.
2004: Nathan C Twaddle; L Patrice McDaniel; Gonçalo Gamboa da Costa; Mona I Churchwell; Frederick A Beland; Daniel R Doerge
Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC-ES/MS/MS.
Cancer letters 2004;207(1):9-17.
2004: Roberta A Mittelstaedt; Linda S Von Tungeln; Joseph G Shaddock; Vasily N Dobrovolsky; Frederick A Beland; Robert H Heflich
Analysis of mutations in the Tk gene of Tk(+/-) mice treated as neonates with 3'-azido-3'-deoxythymidine (AZT).
Mutation research 2004;547(1-2):63-9.
2004: Mugimane G Manjanatha; Sharon D Shelton; M Bishop; Joseph G Shaddock; Vasily N Dobrovolsky; Robert H Heflich; Peggy J Webb; Lonnie R Blankenship; Frederick A Beland; Kevin J Greenlees; Sandra J Culp
Analysis of mutations and bone marrow micronuclei in Big Blue rats fed leucomalachite green.
Mutation research 2004;547(1-2):5-18.
2003: Lee D Williams; Linda S Von Tungeln; Frederick A Beland; Daniel R Doerge
Liquid chromatographic-mass spectrometric determination of the metabolism and disposition of the anti-retroviral nucleoside analogs zidovudine and lamivudine in C57BL/6N and B6C3F1 mice.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;798(1):55-62.
2003: Linge Li; M. Paul Chiarelli; Paula Sério Branco; Alexandra M Antunes; M Matilde Marques; Luísa L Gonçalves; Frederick A Beland
Differentiation of isomeric C8-substituted alkylaniline adducts of guanine by electrospray ionization and tandem quadrupole ion trap mass spectrometry.
Journal of the American Society for Mass Spectrometry 2003;14(12):1488-92.
2003: Gonçalo Gamboa da Costa; Mona I Churchwell; L Patrice Hamilton; Linda S Von Tungeln; Frederick A Beland; M Matilde Marques; Daniel R Doerge
DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice.
Chemical research in toxicology 2003;16(10):1328-37.
2003: Laura J Schild; Rao L Divi; Frederick A Beland; Mona I Churchwell; Daniel R Doerge; Gonçalo Gamboa da Costa; M Matilde Marques; Miriam C Poirier
Formation of tamoxifen-DNA adducts in multiple organs of adult female cynomolgus monkeys dosed with tamoxifen for 30 days.
Cancer research 2003;63(18):5999-6003.
2003: Gonçalo Gamboa da Costa; M Matilde Marques; James P Freeman; Frederick A Beland
Synthesis and investigation of alpha-hydroxy-N,N-didesmethyltamoxifen as a proximate carcinogen in the metabolic activation of tamoxifen.
Chemical research in toxicology 2003;16(9):1090-8.
2003: Ming W Chou; Jian Yan; Jasyl Nichols; Qingsu Xia; Frederick A Beland; Po C Chan; Peter P Fu
Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F(1) mice.
Cancer letters 2003;193(2):119-25.
2003: Gonçalo Gamboa da Costa; M Matilde Marques; Frederick A Beland; James P Freeman; Mona I Churchwell; Daniel R Doerge
Quantification of tamoxifen DNA adducts using on-line sample preparation and HPLC-electrospray ionization tandem mass spectrometry.
Chemical research in toxicology 2003;16(3):357-66.
2003: Bongsup P Cho; Tianle Yang; Lonnie R Blankenship; Joanna D Moody; Mona I Churchwell; Frederick A Beland; Sandra J Culp
Synthesis and characterization of N-demethylated metabolites of malachite green and leucomalachite green.
Chemical research in toxicology 2003;16(3):285-94.
2002: Rao L Divi; Frederick A Beland; Peter P Fu; Linda S Von Tungeln; Bernadette Schoket; Johanna Eltz Camara; Monica Ghei; Nathaniel Rothman; Rashmi Sinha; Miriam C Poirier
Highly sensitive chemiluminescence immunoassay for benzo[a]pyrene-DNA adducts: validation by comparison with other methods, and use in human biomonitoring.
Carcinogenesis 2002;23(12):2043-9.
2002: Mona I Churchwell; Frederick A Beland; Daniel R Doerge
Quantification of multiple DNA adducts formed through oxidative stress using liquid chromatography and electrospray tandem mass spectrometry.
Chemical research in toxicology 2002;15(10):1295-301.
2002: Tao Chen; Gonçalo Gamboa da Costa; M Matilde Marques; Sharon D Shelton; Frederick A Beland; Mugimane G Manjanatha
Mutations induced by alpha-hydroxytamoxifen in the lacI and cII genes of Big Blue transgenic rats.
Carcinogenesis 2002;23(10):1751-7.
2002: Sandra J Culp; Frederick A Beland; Robert H Heflich; R W Benson; Lonnie R Blankenship; Peggy J Webb; Paul W Mellick; Ronald W Trotter; Sharon D Shelton; Kevin J Greenlees; Mugimane G Manjanatha
Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green.
Mutation research 2002;506-507():55-63.
2002: M Matilde Marques; Gonçalo Gamboa da Costa; Lonnie R Blankenship; Sandra J Culp; Frederick A Beland
The effect of deuterium and fluorine substitution upon the mutagenicity of N-hydroxy-2,6-dimethylaniline.
Mutation research 2002;506-507():41-8.
2002: Linda S Von Tungeln; L Patrice Hamilton; Vasily N Dobrovolsky; Michelle E Bishop; Joseph G Shaddock; Robert H Heflich; Frederick A Beland
Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in B6C3F(1)/Tk+/- mice treated neonatally with zidovudine and lamivudine.
Carcinogenesis 2002;23(9):1427-32.
2002: D R Doerge; M I Churchwell; Frederick A Beland
Analysis of DNA adducts from chemical carcinogens and lipid peroxidation using liquid chromatography and electrospray mass spectrometry.
Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews 2002;20(1):1-20.
2002: Clare L Ritter; Sandra J Culp; James P Freeman; M Matilde Marques; Frederick A Beland; Danuta Malejka-Giganti
DNA adducts from nitroreduction of 2,7-dinitrofluorene, a mammary gland carcinogen, catalyzed by rat liver or mammary gland cytosol.
Chemical research in toxicology 2002;15(4):536-44.
2002: Jia-Long Fang; Frederick A Beland; Daniel R Doerge; Doris Wiener; Chantal Guillemette; M Matilde Marques; Philip Lazarus
Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes.
Cancer research 2002;62(7):1978-86.
2002: Gonçalo Gamboa da Costa; Mugimane G Manjanatha; M Matilde Marques; Frederick A Beland
Induction of lacI mutations in Big Blue rats treated with tamoxifen and alpha-hydroxytamoxifen.
Cancer letters 2002;176(1):37-45.
2001: G Gamboa da Costa; L P McDaniel-Hamilton; R H Heflich; M Matilde Marques; Frederick A Beland
DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives.
Carcinogenesis 2001;22(8):1307-15.
2001: Luísa L Gonçalves; Frederick A Beland; M Matilde Marques
Synthesis, characterization, and comparative 32P-postlabeling efficiencies of 2,6-dimethylaniline-DNA adducts.
Chemical research in toxicology 2001;14(2):165-74.
2001: Dean W Roberts; Mona I Churchwell; Frederick A Beland; Jia-Long Fang; Daniel R Doerge
Quantitative analysis of etheno-2'-deoxycytidine DNA adducts using on-line immunoaffinity chromatography coupled with LC/ES-MS/MS detection.
Analytical chemistry 2001;73(2):303-9.
2001: Tao Chen; Roberta A Mittelstaedt; Anane Aidoo; L P Hamilton; Frederick A Beland; Daniel A Casciano; Robert H Heflich
Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorene-treated Big Blue rats.
Environmental and molecular mutagenesis 2001;37(3):195-202.
2000: Daniel R Doerge; Mona I Churchwell; Jia-Long Fang; Frederick A Beland
Quantification of etheno-DNA adducts using liquid chromatography, on-line sample processing, and electrospray tandem mass spectrometry.
Chemical research in toxicology 2000;13(12):1259-64.
2000: Sandra J Culp; Alan Warbritton; B A Smith; E E Li; Frederick A Beland
DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo[a]pyrene.
Carcinogenesis 2000;21(7):1433-40.
2000: Jia-Long Fang; Frederick A Beland
Development of a novel (32)P-postlabeling method for the analysis of 3'-azido-3'-deoxythymidine.
Cancer letters 2000;153(1-2):25-33.
2000: Ming W Chou; MV Mikhailova; Jasyl Nichols; Lionel A Poirier; Alan Warbritton; Frederick A Beland
Interactive effects of methyl-deficiency and dietary restriction on liver cell proliferation and telomerase activity in Fischer 344 rats pretreated with aflatoxin B(1).
Cancer letters 2000;152(1):53-61.
2000: Gonçalo Gamboa da Costa; L Patrice Hamilton; Frederick A Beland; M Matilde Marques
Characterization of the major DNA adduct formed by alpha-hydroxy-N-desmethyltamoxifen in vitro and in vivo.
Chemical research in toxicology 2000;13(3):200-7.
2000: David W Gaylor; Sandra J Culp; Lawrence S Goldstein; Frederick A Beland
Cancer risk estimation for mixtures of coal tars and benzo(a)pyrene.
Risk analysis : an official publication of the Society for Risk Analysis 2000;20(1):81-5.
1999: Roberta A Mittelstaedt; BA Smith; Tao Chen; Frederick A Beland; Robert H Heflich
Sequence specificity of Hprt lymphocyte mutation in rats fed the hepatocarcinogen 2-acetylaminofluorene.
Mutation research 1999;431(1):167-73.
1999: Sandra J Culp; Lonnie R Blankenship; D F Kusewitt; Daniel R Doerge; L T Mulligan; Frederick A Beland
Toxicity and metabolism of malachite green and leucomalachite green during short-term feeding to Fischer 344 rats and B6C3F1 mice.
Chemico-biological interactions 1999;122(3):153-70.
1999: Frederick A Beland; NF Fullerton; BA Smith; Roberta A Mittelstaedt; Robert H Heflich
Hprt lymphocyte mutant frequency in relation to DNA adduct formation in rats fed the hepatocarcinogen 2-acetylaminofluorene.
Cancer letters 1999;143(2):249-55.
1999: LL Mourato; Frederick A Beland; M Matilde Marques
32P-Postlabeling of N-(deoxyguanosin-8-yl)arylamine adducts: a comparative study of labeling efficiencies.
Chemical research in toxicology 1999;12(7):661-9.
1999: Daniel R Doerge; Mona I Churchwell; M M Marques; Frederick A Beland
Quantitative analysis of 4-aminobiphenyl-C8-deoxyguanosyl DNA adducts produced in vitro and in vivo using HPLC-ES-MS.
Carcinogenesis 1999;20(6):1055-61.
1999: Frederick A Beland; L P McDaniel; M Matilde Marques
Comparison of the DNA adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo.
Carcinogenesis 1999;20(3):471-7.
1999: Frederick A Beland; Daniel R Doerge; Mona I Churchwell; Miriam C Poirier; Bernadette Schoket; M Matilde Marques
Synthesis, characterization, and quantitation of a 4-aminobiphenyl-DNA adduct standard.
Chemical research in toxicology 1999;12(1):68-77.
1998: Lawrence S Goldstein; Eric H Weyand; Stephen Safe; M Steinberg; Sandra J Culp; David W Gaylor; Frederick A Beland; Lewis V Rodriguez
Tumors and DNA adducts in mice exposed to benzo[a]pyrene and coal tars: implications for risk assessment.
Environmental health perspectives 1998;106 Suppl 6():1325-30.
1998: Frederick A Beland; T C Schmitt; NF Fullerton; John F Young
Metabolism of chloral hydrate in mice and rats after single and multiple doses.
Journal of toxicology and environmental health. Part A 1998;54(3):209-26.
1998: Sandra J Culp; David W Gaylor; W G Sheldon; Lawrence S Goldstein; Frederick A Beland
A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay.
Carcinogenesis 1998;19(1):117-24.
1997: M Matilde Marques; LL Mourato; M T Amorim; M A Santos; William B Melchior; Frederick A Beland
Effect of substitution site upon the oxidation potentials of alkylanilines, the mutagenicities of N-hydroxyalkylanilines, and the conformations of alkylaniline-DNA adducts.
Chemical research in toxicology 1997;10(11):1266-74.
1997: M Matilde Marques; Frederick A Beland
Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide.
Carcinogenesis 1997;18(10):1949-54.
1997: BA Smith; Mugimane G Manjanatha; Igor P Pogribny; Roberta A Mittelstaedt; Tao Chen; NF Fullerton; Frederick A Beland; Robert H Heflich
Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene.
Mutation research 1997;379(1):61-8.
1997: Miriam C Poirier; Frederick A Beland
Aromatic amine DNA adduct formation in chronically-exposed mice: considerations for human comparison.
Mutation research 1997;376(1-2):177-84.
1997: Frederick A Beland; William B Melchior; LL Mourato; M A Santos; M Matilde Marques
Arylamine-DNA adduct conformation in relation to mutagenesis.
Mutation research 1997;376(1-2):13-9.
1996: Mugimane G Manjanatha; Lascelles E Lyn-Cook; S J Culp; Frederick A Beland; Robert H Heflich; Anane Aidoo
Lymphocyte mutant frequency in relation to DNA adduct formation in rats treated with tumorigenic doses of the mammary gland carcinogen 7,12-dimethylbenz[a]anthracene.
Mutation research 1996;357(1-2):89-96.
1996: M Matilde Marques; L L Mourato; M A Santos; Frederick A Beland
Synthesis, characterization, and conformational analysis of DNA adducts from methylated anilines present in tobacco smoke.
Chemical research in toxicology 1996;9(1):99-108.
1995: Frederick A Beland
DNA adduct formation and T lymphocyte mutation induction in F344 rats implanted with tumorigenic doses of 1,6-dinitropyrene.
Research report (Health Effects Institute) 1995;(72):1-27; discussion 29-39.
1995: B A Smith; N F Fullerton; Robert H Heflich; Frederick A Beland
DNA adduct formation and T-lymphocyte mutation induction in F344 rats implanted with tumorigenic doses of 1,6-dinitropyrene.
Cancer research 1995;55(11):2316-24.
1995: D Herreno-Saenz; F E Evans; Frederick A Beland; Peter P Fu
Identification of two N2-deoxyguanosinyl DNA adducts upon nitroreduction of the environmental mutagen 1-nitropyrene.
Chemical research in toxicology 1995;8(2):269-77.
1994: Frederick A Beland; N F Fullerton; B A Smith; Robert H Heflich
Formation of DNA adducts and induction of mutations in rats treated with tumorigenic doses of 1,6-dinitropyrene.
Environmental health perspectives 1994;102 Suppl 6():185-9.
1994: William B Melchior; M Matilde Marques; Frederick A Beland
Mutations induced by aromatic amine DNA adducts in pBR322.
Carcinogenesis 1994;15(5):889-99.
1994: B P Cho; Frederick A Beland; M Matilde Marques
NMR structural studies of a 15-mer DNA duplex from a ras protooncogene modified with the carcinogen 2-aminofluorene: conformational heterogeneity.
Biochemistry 1994;33(6):1373-84.
1994: S J Culp; Frederick A Beland
Comparison of DNA adduct formation in mice fed coal tar or benzo[a]pyrene.
Carcinogenesis 1994;15(2):247-52.
1994: Frederick A Beland; M Matilde Marques
DNA adducts of nitropolycyclic aromatic hydrocarbons.
IARC scientific publications 1994;(125):229-44.
1993: Frederick A Beland; M C Poirier
Significance of DNA adduct studies in animal models for cancer molecular dosimetry and risk assessment.
Environmental health perspectives 1993;99():5-10.
1993: B A Smith; N F Fullerton; A Aidoo; Robert H Heflich; Frederick A Beland
DNA adduct formation in relation to lymphocyte mutations and lung tumor induction in F344 rats treated with the environmental pollutant 1,6-dinitropyrene.
Environmental health perspectives 1993;99():277-80.
1993: S J Culp; M C Poirier; Frederick A Beland
Biphasic removal of DNA adducts in a repetitive DNA sequence after dietary administration of 2-acetylaminofluorene.
Environmental health perspectives 1993;99():273-5.
1992: David W Gaylor; Fred F Kadlubar; Frederick A Beland
Application of biomarkers to risk assessment.
Environmental health perspectives 1992;98():139-41.
1992: B P Cho; Frederick A Beland; M Matilde Marques
NMR structural studies of a 15-mer DNA sequence from a ras protooncogene, modified at the first base of codon 61 with the carcinogen 4-aminobiphenyl.
Biochemistry 1992;31(40):9587-602.
1992: Frederick A Beland; B A Smith; J R Thornton-Manning; Robert H Heflich
Metabolic activation of 1-nitropyrene to a mammalian cell mutagen and a carcinogen.
Xenobiotica; the fate of foreign compounds in biological systems 1992;22(9-10):1121-33.
1992: Frederick A Beland; N F Fullerton; B A Smith; M C Poirier
DNA adduct formation and aromatic amine tumorigenesis.
Progress in clinical and biological research 1992;374():79-92.
1991: J R Thornton-Manning; B A Smith; Frederick A Beland; Robert H Heflich
S9-mediated metabolism of 1-nitropyrene to a mutagen in Chinese hamster ovary cells by ring-oxidation under aerobic conditions and by nitroreduction under anaerobic conditions.
Carcinogenesis 1991;12(12):2317-23.
1991: J R Thornton-Manning; B A Smith; Frederick A Beland; Robert H Heflich
Mutagenesis and DNA adduct formation by 1-nitropyrene in Chinese hamster ovary cells without exogenous metabolic activation.
Toxicology and applied pharmacology 1991;109(3):538-46.
1990: B A Smith; W A Korfmacher; Frederick A Beland
DNA adduct formation in target tissues of Sprague-Dawley rats, CD-1 mice and A/J mice following tumorigenic doses of 1-nitropyrene.
Carcinogenesis 1990;11(10):1705-10.
1990: Fred F Kadlubar; Peter P Fu; H Jung; A U Shaikh; Frederick A Beland
The metabolic N-oxidation of carcinogenic arylamines in relation to nitrogen charge density and oxidation potential.
Environmental health perspectives 1990;87():233-6.
1990: Robert H Heflich; J R Thornton-Manning; T Kinouchi; Frederick A Beland
Mutagenicity of oxidized microsomal metabolites of 1-nitropyrene in Chinese hamster ovary cells.
Mutagenesis 1990;5(2):151-7.
1990: Frederick A Beland; N F Fullerton; T Kinouchi; B A Smith; M C Poirier
DNA adduct formation in relation to tumorigenesis in mice chronically fed 2-acetylaminofluorene.
Progress in clinical and biological research 1990;331():121-9; discussion 147-8.
1990: Frederick A Beland; N F Fullerton; M Matilde Marques; William B Melchior; B A Smith; M C Poirier
DNA adduct formation in relation to tumorigenesis in mice continuously administered 4-aminobiphenyl.
Progress in clinical and biological research 1990;340A():81-90.
1989: H R Prasanna; Ming H Lu; Frederick A Beland; Ronald W Hart
Inhibition of aflatoxin B1 binding to hepatic DNA by dehydroepiandrosterone in vivo.
Carcinogenesis 1989;10(12):2197-200.
1989: Frederick A Beland
Metabolic activation of aromatic amine carcinogens in vitro and in vivo.
Journal of UOEH 1989;11 Suppl():387-97.
1988: Zora Djuric Longworth; E K Fifer; Y Yamazoe; Frederick A Beland
DNA binding by 1-nitropyrene and 1,6-dinitropyrene in vitro and in vivo: effects of nitroreductase induction.
Carcinogenesis 1988;9(3):357-64.
1988: Robert H Heflich; Zora Djuric Longworth; Z Zhuo; N F Fullerton; Daniel A Casciano; Frederick A Beland
Metabolism of 2-acetylaminofluorene in the Chinese hamster ovary cell mutation assay.
Environmental and molecular mutagenesis 1988;11(2):167-81.
1988: Frederick A Beland; N F Fullerton; T Kinouchi; M C Poirier
DNA adduct formation during continuous feeding of 2-acetylaminofluorene at multiple concentrations.
IARC scientific publications 1988;(89):175-80.
1987: Zora Djuric Longworth; B Coles; E K Fifer; B Ketterer; Frederick A Beland
In vivo and in vitro formation of glutathione conjugates from the K-region epoxides of 1-nitropyrene.
Carcinogenesis 1987;8(12):1781-6.
1986: E K Fifer; P C Howard; Robert H Heflich; Frederick A Beland
Synthesis and mutagenicity of 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide, microsomal metabolites of 1-nitropyrene.
Mutagenesis 1986;1(6):433-8.
1986: Zora Djuric Longworth; E K Fifer; P C Howard; Frederick A Beland
Oxidative microsomal metabolism of 1-nitropyrene and DNA-binding of oxidized metabolites following nitroreduction.
Carcinogenesis 1986;7(7):1073-9.
1986: Robert H Heflich; Suzanne M Morris; D T Beranek; Lynda J McGarrity; J J Chen; Frederick A Beland
Relationships between the DNA adducts and the mutations and sister-chromatid exchanges produced in Chinese hamster ovary cells by N-hydroxy-2-aminofluorene, N-hydroxy-N'-acetylbenzidine and 1-nitrosopyrene.
Mutagenesis 1986;1(3):201-6.
1986: Robert H Heflich; Zora Djuric Longworth; E K Fifer; C E Cerniglia; Frederick A Beland
Metabolism of dinitropyrenes to DNA-binding derivatives in vitro and in vivo.
Developments in toxicology and environmental science 1986;13():185-97.
1986: Robert H Heflich; E K Fifer; Zora Djuric Longworth; Frederick A Beland
Mutation induction and DNA adduct formation by 1,8-dinitropyrene in Chinese hamster ovary cells.
Progress in clinical and biological research 1986;209A():265-73.
1986: E K Fifer; Robert H Heflich; Zora Djuric Longworth; P C Howard; Frederick A Beland
Synthesis and mutagenicity of 1-nitro-6-nitrosopyrene and 1-nitro-8-nitrosopyrene, potential intermediates in the metabolic activation of 1,6- and 1,8-dinitropyrene.
Carcinogenesis 1986;7(1):65-70.
1985: Robert H Heflich; E K Fifer; Zora Djuric Longworth; Frederick A Beland
DNA adduct formation and mutation induction by nitropyrenes in Salmonella and Chinese hamster ovary cells: relationships with nitroreduction and acetylation.
Environmental health perspectives 1985;62():135-43.
1980: Peter P Fu; Frederick A Beland; S K Yang
Cyclopenta-polycyclic aromatic hydrocarbons: potential carcinogens and mutagens.
Carcinogenesis 1980;1(8):725-7.
1980: Fred F Kadlubar; K M Straub; L E Unruh; Frederick A Beland; F E Evans
In vitro reaction of the carcinogen, N-hydroxy-2-naphthylamine, with DNA at the C-8 and N2 atoms of guanine and at the N6 atom of adenine.
Carcinogenesis 1980;1(2):139-50.
1980: F E Evans; D W Miller; Frederick A Beland
Sensitivity of the conformation of deoxyguanosine to binding at the C-8 position by N-acetylated and unacetylated 2-aminofluorene.
Carcinogenesis 1980;1(11):955-9.