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Alexey Murzin

Research Profile

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

Protein Folding

Chemicals & Drugs

Phenomena

Living Beings

Escherichia coli

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Publications

TOP 3
Antonina Andreeva; Alexey G Murzin
Structural classification of proteins and structural genomics: new insights into protein folding and evolution.
Antonina Andreeva; Alexey G Murzin
A fortuitous insight into a common mode of RNA recognition by the dsRNA-specific zinc fingers.
Alexey G Murzin
Biochemistry. Metamorphic proteins.

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All Publications

2010: Antonina Andreeva; Alexey G Murzin
Structural classification of proteins and structural genomics: new insights into protein folding and evolution.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 10):1190-7.
2008: Antonina Andreeva; Alexey G Murzin
A fortuitous insight into a common mode of RNA recognition by the dsRNA-specific zinc fingers.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(52):E128-9.
2008: Alexey G Murzin
Biochemistry. Metamorphic proteins.
Science (New York, N.Y.) 2008;320(5884):1725-6.
2008: Michael Proudfoot; Stephen A Sanders; Alex Singer; Rongguang Zhang; Greg Brown; Andrew Binkowski; Linda Xu; Jonathan A Lukin; Alexey G Murzin; Andrzej Joachimiak; Cheryl H Arrowsmith; Aled M Edwards; Alexei V Savchenko; Alexander F Yakunin
Biochemical and structural characterization of a novel family of cystathionine beta-synthase domain proteins fused to a Zn ribbon-like domain.
Journal of molecular biology 2008;375(1):301-15.
2008: Antonina Andreeva; Dave Howorth; John-Marc Chandonia; Steven E Brenner; Tim Hubbard; Cyrus Chothia; Alexey G Murzin
Data growth and its impact on the SCOP database: new developments.
Nucleic acids research 2008;36(Database issue):D419-25.
2007: Antonina Andreeva; Andreas Prlić; Tim Hubbard; Alexey G Murzin
SISYPHUS--structural alignments for proteins with non-trivial relationships.
Nucleic acids research 2007;35(Database issue):D253-9.
2006: Benjamin G Bobay; Geoffrey A Mueller; Richele J Thompson; Alexey G Murzin; Ronald A Venters; Mark A Strauch; John Cavanagh
NMR structure of AbhN and comparison with AbrBN: FIRST insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins.
The Journal of biological chemistry 2006;281(30):21399-409.
2006: Antonina Andreeva; Alexey G Murzin
Evolution of protein fold in the presence of functional constraints.
Current opinion in structural biology 2006;16(3):399-408.
2006: Galina V Mukamolova; Alexey G Murzin; Elena G Salina; Galina R Demina; Douglas B Kell; Arseny S Kaprelyants; Michael Young
Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation.
Molecular microbiology 2006;59(1):84-98.
2006: Michael Galperin; Olga V Moroz; Keith S Wilson; Alexey G Murzin
House cleaning, a part of good housekeeping.
Molecular microbiology 2006;59(1):5-19.
2005: Benjamin G Bobay; Antonina Andreeva; Geoffrey A Mueller; John Cavanagh; Alexey G Murzin
Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins.
FEBS letters 2005;579(25):5669-74.
2005: Peter R Nielsen; Daniel Nietlispach; Alessia Buscaino; Rosemary J Warner; Asifa Akhtar; Alexey G Murzin; Natalia V Murzina; Ernest D Laue
Structure of the chromo barrel domain from the MOF acetyltransferase.
The Journal of biological chemistry 2005;280(37):32326-31.
2005: Olga V Moroz; Alexey G Murzin; Kira S Makarova; Eugene V Koonin; Keith S Wilson; Michael Galperin
Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions.
Journal of molecular biology 2005;347(2):243-55.
2004: William H Johnson; Susan C Wang; Thanuja M Stanley; Robert M Czerwinski; Jeffrey J Almrud; Gerrit J Poelarends; Alexey G Murzin; Christian P Whitman
4-Oxalocrotonate tautomerase, its homologue YwhB, and active vinylpyruvate hydratase: synthesis and evaluation of 2-fluoro substrate analogues.
Biochemistry 2004;43(32):10490-501.
2004: Gerrit J Poelarends; Hector Serrano; Maria D Person; William H Johnson; Alexey G Murzin; Christian P Whitman
Cloning, expression, and characterization of a cis-3-chloroacrylic acid dehalogenase: insights into the mechanistic, structural, and evolutionary relationship between isomer-specific 3-chloroacrylic acid dehalogenases.
Biochemistry 2004;43(3):759-72.
2004: Peter R Nielsen; Juliana Callaghan; Alexey G Murzin; Natalia V Murzina; Ernest D Laue
Expression, purification, and biophysical studies of chromodomain proteins.
Methods in enzymology 2004;376():148-70.
2004: Antonina Andreeva; Dave Howorth; Steven E Brenner; Tim Hubbard; Cyrus Chothia; Alexey G Murzin
SCOP database in 2004: refinements integrate structure and sequence family data.
Nucleic acids research 2004;32(Database issue):D226-9.
2003: Gerrit J Poelarends; William H Johnson; Alexey G Murzin; Christian P Whitman
Mechanistic characterization of a bacterial malonate semialdehyde decarboxylase: identification of a new activity on the tautomerase superfamily.
The Journal of biological chemistry 2003;278(49):48674-83.
2003: Aruna Sathyamurthy; Mark D Allen; Alexey G Murzin; Mark Bycroft
Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2).
The Journal of biological chemistry 2003;278(47):46968-73.
2003: Christopher Lehmann; Kap Lim; Vani Rao Chalamasetty; Wojciech Krajewski; Eugene Melamud; Andrey Galkin; Andrew Howard; Zvi Kelman; Prasad T Reddy; Alexey G Murzin; Osnat Herzberg
The HI0073/HI0074 protein pair from Haemophilus influenzae is a member of a new nucleotidyltransferase family: structure, sequence analyses, and solution studies.
Proteins 2003;50(2):249-60.
2002: Jeffrey J Almrud; Andrew D Kern; Susan C Wang; Robert M Czerwinski; William H Johnson; Alexey G Murzin; Marvin L Hackert; Christian P Whitman
The crystal structure of YdcE, a 4-oxalocrotonate tautomerase homologue from Escherichia coli, confirms the structural basis for oligomer diversity.
Biochemistry 2002;41(40):12010-24.
2002: Alexey G Murzin
Biochemistry. DNA building block reinvented.
Science (New York, N.Y.) 2002;297(5578):61-2.
2002: Peter R Nielsen; Daniel Nietlispach; Helen R Mott; Juliana Callaghan; Andrew J Bannister; Tony Kouzarides; Alexey G Murzin; Natalia V Murzina; Ernest D Laue
Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9.
Nature 2002;416(6876):103-7.
2002: Loredana Lo Conte; Steven E Brenner; Tim Hubbard; Cyrus Chothia; Alexey G Murzin
SCOP database in 2002: refinements accommodate structural genomics.
Nucleic acids research 2002;30(1):264-7.
2001: Sarah A Teichmann; Alexey G Murzin; Cyrus Chothia
Determination of protein function, evolution and interactions by structural genomics.
Current opinion in structural biology 2001;11(3):354-63.
2001: Alexey G Murzin; A Bateman
CASP2 knowledge-based approach to distant homology recognition and fold prediction in CASP4.
Proteins 2001;Suppl 5():76-85.
2001: Alexey G Murzin; Tim Hubbard
Prediction targets of CASP4.
Proteins 2001;Suppl 5():8-12.
2000: Loredana Lo Conte; B Ailey; Tim Hubbard; Steven E Brenner; Alexey G Murzin; Cyrus Chothia
SCOP: a structural classification of proteins database.
Nucleic acids research 2000;28(1):257-9.
1999: Kenji Mizuguchi; Venugopal Dhanaraj; Tom L Blundell; Alexey G Murzin
N-ethylmaleimide-sensitive fusion protein (NSF) and CDC48 confirmed as members of the double-psi beta-barrel aspartate decarboxylase/formate dehydrogenase family.
Structure (London, England : 1993) 1999;7(9):R215-6.
1999: R M Castillo; Kenji Mizuguchi; Venugopal Dhanaraj; A Albert; Tom L Blundell; Alexey G Murzin
A six-stranded double-psi beta barrel is shared by several protein superfamilies.
Structure (London, England : 1993) 1999;7(2):227-36.
1999: Alexey G Murzin
Structure classification-based assessment of CASP3 predictions for the fold recognition targets.
Proteins 1999;Suppl 3():88-103.
1999: Tim Hubbard; B Ailey; Steven E Brenner; Alexey G Murzin; Cyrus Chothia
SCOP: a Structural Classification of Proteins database.
Nucleic acids research 1999;27(1):254-6.
1998: Tim Hubbard; B Ailey; Steven E Brenner; Alexey G Murzin; Cyrus Chothia
SCOP, Structural Classification of Proteins database: applications to evaluation of the effectiveness of sequence alignment methods and statistics of protein structural data.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 6 Pt 1):1147-54.
1998: Alexey G Murzin
How far divergent evolution goes in proteins.
Current opinion in structural biology 1998;8(3):380-7.
1998: A Bateman; Alexey G Murzin; Sarah A Teichmann
Structure and distribution of pentapeptide repeats in bacteria.
Protein science : a publication of the Protein Society 1998;7(6):1477-80.
1997: L J Ball; Natalia V Murzina; R William Broadhurst; Andrew R C Raine; Sharon J Archer; F J Stott; Alexey G Murzin; P B Singh; Peter J Domaille; Ernest D Laue
Structure of the chromatin binding (chromo) domain from mouse modifier protein 1.
The EMBO journal 1997;16(9):2473-81.
1997: Mark Bycroft; Tim Hubbard; M Proctor; Stefan M V Freund; Alexey G Murzin
The solution structure of the S1 RNA binding domain: a member of an ancient nucleic acid-binding fold.
Cell 1997;88(2):235-42.
1997: Cyrus Chothia; Tim Hubbard; Steven E Brenner; H Barns; Alexey G Murzin
Protein folds in the all-beta and all-alpha classes.
Annual review of biophysics and biomolecular structure 1997;26():597-627.
1997: Tim Hubbard; Alexey G Murzin; Steven E Brenner; Cyrus Chothia
SCOP: a structural classification of proteins database.
Nucleic acids research 1997;25(1):236-9.
1996: Steven E Brenner; Cyrus Chothia; Tim Hubbard; Alexey G Murzin
Understanding protein structure: using scop for fold interpretation.
Methods in enzymology 1996;266():635-43.
1995: Steven E Brenner; Tim Hubbard; Alexey G Murzin; Cyrus Chothia
Gene duplications in H. influenzae.
Nature 1995;378(6553):140.
1995: Mark Bycroft; stefan gruenert; Alexey G Murzin; Mark R Proctor; Daniel St Johnston
NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal protein S5.
The EMBO journal 1995;14(14):3563-71.
1995: Alexey G Murzin; Steven E Brenner; Tim Hubbard; Cyrus Chothia
SCOP: a structural classification of proteins database for the investigation of sequences and structures.
Journal of molecular biology 1995;247(4):536-40.
1994: Maria Kireeva; N V Murzina; Alexey G Murzin; Vladimir Uversky; O I Gryaznova; Anatoly T Gudkov
Circularly permuted dihydrofolate reductase of E. coli has functional activity and a destabilized tertiary structure.
Protein engineering 1994;7(11):1373-7.
1994: Alexey G Murzin; Arthur M Lesk; Cyrus Chothia
Principles determining the structure of beta-sheet barrels in proteins. II. The observed structures.
Journal of molecular biology 1994;236(5):1382-400.
1994: Alexey G Murzin; Arthur M Lesk; Cyrus Chothia
Principles determining the structure of beta-sheet barrels in proteins. I. A theoretical analysis.
Journal of molecular biology 1994;236(5):1369-81.
1993: Cyrus Chothia; Alexey G Murzin
New folds for all-beta proteins.
Structure (London, England : 1993) 1993;1(4):217-22.
1993: Alexey G Murzin
Sweet-tasting protein monellin is related to the cystatin family of thiol proteinase inhibitors.
Journal of molecular biology 1993;230(2):689-94.
1993: V V Leontiev; Vladimir Uversky; Eugene A Permyakov; Alexey G Murzin
Introduction of Ca(2+)-binding amino-acid sequence into the T4 lysozyme.
Biochimica et biophysica acta 1993;1162(1-2):84-8.
1993: Alexey G Murzin
OB(oligonucleotide/oligosaccharide binding)-fold: common structural and functional solution for non-homologous sequences.
The EMBO journal 1993;12(3):861-7.
1992: Alexey G Murzin
Structural principles for the propeller assembly of beta-sheets: the preference for seven-fold symmetry.
Proteins 1992;14(2):191-201.
1992: Alexey G Murzin; Arthur M Lesk; Cyrus Chothia
beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors.
Journal of molecular biology 1992;223(2):531-43.
1988: Alexey G Murzin; Alexei V Finkelstein
General architecture of the alpha-helical globule.
Journal of molecular biology 1988;204(3):749-69.
1986: OB Ptitsyn; A V Finkel'shteĭn; Alexey G Murzin
[Predicting the three-dimensional structure of alpha- and beta-interferons].
Molekuliarnaia biologiia 1986;20(1):21-8.
1985: OB Ptitsyn; Alexei V Finkelstein; Alexey G Murzin
Structural model for interferons.
FEBS letters 1985;186(2):143-8.