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John Musachio

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James Robert Brasic; Yun Zhou; John L Musachio; John Hilton; Hong Fan; ANDREW CRABB; Christopher J Endres; Melvin J Reinhardt; A. Semih Dogan; Mohab Alexander; Olivier Rousset; Marika A Maris; Jeffrey Galecki; Ayon Nandi; Dean F Wong
Single photon emission computed tomography experience with (S)-5-[(123)I]iodo-3-(2-azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers.
Masao Imaizumi; Emmanuelle Briard; Sami S Zoghbi; Jonathan P Gourley; Jinsoo Hong; John L Musachio; Robert L Gladding; Victor W Pike; Robert B Innis; Masahiro Fujita
Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain.
H Umesha Shetty; Sami S Zoghbi; Jeih-San Liow; Masanori Ichise; Jinsoo Hong; John L Musachio; Christer Halldin; Jurgen Seidel; Robert B Innis; Victor W Pike
Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I.

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All Publications

2009: James Robert Brasic; Yun Zhou; John L Musachio; John Hilton; Hong Fan; ANDREW CRABB; Christopher J Endres; Melvin J Reinhardt; A. Semih Dogan; Mohab Alexander; Olivier Rousset; Marika A Maris; Jeffrey Galecki; Ayon Nandi; Dean F Wong
Single photon emission computed tomography experience with (S)-5-[(123)I]iodo-3-(2-azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers.
Synapse (New York, N.Y.) 2009;63(4):339-58.
2007: Masao Imaizumi; Emmanuelle Briard; Sami S Zoghbi; Jonathan P Gourley; Jinsoo Hong; John L Musachio; Robert L Gladding; Victor W Pike; Robert B Innis; Masahiro Fujita
Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain.
Synapse (New York, N.Y.) 2007;61(8):595-605.
2007: H Umesha Shetty; Sami S Zoghbi; Jeih-San Liow; Masanori Ichise; Jinsoo Hong; John L Musachio; Christer Halldin; Jurgen Seidel; Robert B Innis; Victor W Pike
Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I.
European journal of nuclear medicine and molecular imaging 2007;34(5):667-78.
2007: Jose A Rodríguez-Gómez; Jian-Qiang Lu; Iván Velasco; Seth N Rivera; Sami S Zoghbi; Jeih-San Liow; John L Musachio; Frederick T Chin; Hiroshi Toyama; Jurgen Seidel; Michael V Green; Panayotis K Thanos; Masanori Ichise; Victor W Pike; Robert B Innis; Ronald D G McKay
Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson disease.
Stem cells (Dayton, Ohio) 2007;25(4):918-28.
2007: Jeih-San Liow; Shuiyu Lu; Julie A McCarron; Jinsoo Hong; John L Musachio; Victor W Pike; Robert B Innis; Sami S Zoghbi
Effect of a P-glycoprotein inhibitor, Cyclosporin A, on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand, [11C](R)-(-)-RWAY.
Synapse (New York, N.Y.) 2007;61(2):96-105.
2007: Masahiro Fujita; Masao Imaizumi; Carrol D'Sa; Sami S Zoghbi; Matthew S Crescenzo; Jinsoo Hong; John L Musachio; Antony D Gee; Jurgen Seidel; Michael V Green; Victor W Pike; Ronald S Duman; Robert B Innis
In vivo and in vitro measurement of brain phosphodiesterase 4 in rats after antidepressant administration.
Synapse (New York, N.Y.) 2007;61(2):78-86.
2007: Masao Imaizumi; Hyun-Ju Kim; Sami S Zoghbi; Emmanuelle Briard; Jinsoo Hong; John L Musachio; Christl Ruetzler; De-Maw Chuang; Victor W Pike; Robert B Innis; Masahiro Fujita
PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat.
Neuroscience letters 2007;411(3):200-5.
2006: Yingxian Xiao; Hong Fan; John L Musachio; Zhi-Liang Wei; Sheela K Chellappan; Alan P Kozikowski; Kenneth J Kellar
Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them.
Molecular pharmacology 2006;70(4):1454-60.
2006: John L Musachio; Jinsoo Hong; Masanori Ichise; Nicholas Seneca; Amira K Brown; Jeih-San Liow; Christer Halldin; Robert B Innis; Victor W Pike; Rong He; Jia Zhou; Alan P Kozikowski
Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(12):3101-4.
2006: Sami S Zoghbi; H Umesha Shetty; Masanori Ichise; Masahiro Fujita; Masao Imaizumi; Jeih-San Liow; Jay Shah; John L Musachio; Victor W Pike; Robert B Innis
PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(3):520-7.
2006: Vanessa L Cropley; Masahiro Fujita; John L Musachio; Jinsoo Hong; Subroto Ghose; Janet Sangare; Pradeep Nathan; Victor W Pike; Robert B Innis
Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humans.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(1):100-4.
2005: Masahiro Fujita; Sami S Zoghbi; Matthew S Crescenzo; Jinsoo Hong; John L Musachio; Jian-Qiang Lu; Jeih-San Liow; Nicholas Seneca; Dnyanesh N Tipre; Vanessa L Cropley; Masao Imaizumi; Antony D Gee; Jurgen Seidel; Michael V Green; Victor W Pike; Robert B Innis
Quantification of brain phosphodiesterase 4 in rat with (R)-[11C]Rolipram-PET.
NeuroImage 2005;26(4):1201-10.
2005: Hiroshi Toyama; Daniel Ye; Masanori Ichise; Jeih-San Liow; Lisheng Cai; David Jacobowitz; John L Musachio; Jinsoo Hong; Mathew Crescenzo; Dnyanesh N Tipre; Jian-Qiang Lu; Sami S Zoghbi; Douglass C Vines; Jurgen Seidel; Kazuhiro Katada; Michael V Green; Victor W Pike; Robert M Cohen; Robert B Innis
PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease.
European journal of nuclear medicine and molecular imaging 2005;32(5):593-600.
2005: Zhi-Liang Wei; Yingxian Xiao; Hongbin Yuan; Maryna Baydyuk; Pavel A Petukhov; John L Musachio; Kenneth J Kellar; Alan P Kozikowski
Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits.
Journal of medicinal chemistry 2005;48(6):1721-4.
2005: Martin G Pomper; Eifion Phillips; Hong Fan; Dennis J McCarthy; Richard A Keith; John C Gordon; Ursula Scheffel; Robert F Dannals; John L Musachio
Synthesis and biodistribution of radiolabeled alpha 7 nicotinic acetylcholine receptor ligands.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(2):326-34.
2004: Shui-Yu Lu; Paul Watts; Frederick T Chin; Jinsoo Hong; John L Musachio; Emmanuelle Briard; Victor W Pike
Syntheses of 11C- and 18F-labeled carboxylic esters within a hydrodynamically-driven micro-reactor.
Lab on a chip 2004;4(6):523-5.
2003: Martha I Dávila-García; John L Musachio; Kenneth J Kellar
Chronic nicotine administration does not increase nicotinic receptors labeled by [125I]epibatidine in adrenal gland, superior cervical ganglia, pineal or retina.
Journal of neurochemistry 2003;85(5):1237-46.
2003: Maryka Quik; Jocelyn D Sum; Paul Whiteaker; Sarah E McCallum; Michael J Marks; John L Musachio; J Michael McIntosh; Allan C Collins; Sharon R Grady
Differential declines in striatal nicotinic receptor subtype function after nigrostriatal damage in mice.
Molecular pharmacology 2003;63(5):1169-79.
2002: Michael Kassiou; Christian Loc'h; Frederic Dolle; John L Musachio; L Dolci; Christian Crouzel; Robert F Dannals; B Mazière
Preparation of a bromine-76 labelled analogue of epibatidine: a potent ligand for nicotinic acetylcholine receptor studies.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2002;57(5):713-7.
2002: Jennifer M Kulak; John L Musachio; J Michael McIntosh; Maryka Quik
Declines in different beta2* nicotinic receptor populations in monkey striatum after nigrostriatal damage.
The Journal of pharmacology and experimental therapeutics 2002;303(2):633-9.
2002: David C Perry; Yingxian Xiao; Henry N Nguyen; John L Musachio; Martha I Dávila-García; Kenneth J Kellar
Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography.
Journal of neurochemistry 2002;82(3):468-81.
2002: Michael Kassiou; Michel Bottlaender; Christian Loc'h; Frederic Dolle; John L Musachio; Christine Coulon; Michèle Ottaviani; Robert F Dannals; Bernard Maziere
Pharmacological evaluation of a Br-76 analog of epibatidine: a potent ligand for studying brain nicotinic acetylcholine receptors.
Synapse (New York, N.Y.) 2002;45(2):95-104.
2002: badreddine bencherif; Christopher J Endres; John L Musachio; A Villalobos; John Hilton; Ursula Scheffel; Robert F Dannals; S Williams; J James Frost
PET imaging of brain acetylcholinesterase using [11C]CP-126,998, a brain selective enzyme inhibitor.
Synapse (New York, N.Y.) 2002;45(1):1-9.
2002: John L Musachio; John E Flesher; Ursula Scheffel; Paige A Rauseo; John Hilton; William B Mathews; Hayden T Ravert; Robert F Dannals; J James Frost
Radiosynthesis and mouse brain distribution studies of [11C] CP-126,998: a PET ligand for in vivo study of acetylcholinesterase.
Nuclear medicine and biology 2002;29(5):547-52.
2002: Martin G Pomper; John L Musachio; Jiazhong Zhang; Ursula Scheffel; Yun Zhou; John Hilton; Atul Maini; Robert F Dannals; Dean F Wong; Alan P Kozikowski
11C-MCG: synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase).
Molecular imaging 2002;1(2):96-101.
2002: Jennifer M Kulak; Jocelyn D Sum; John L Musachio; J Michael McIntosh; Maryka Quik
5-Iodo-A-85380 binds to alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors (nAChRs) as well as alpha4beta2* subtypes.
Journal of neurochemistry 2002;81(2):403-6.
2002: Hayden T Ravert; Ursula Scheffel; William B Mathews; John L Musachio; Robert F Dannals
[(11)C]-GR89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers.
Nuclear medicine and biology 2002;29(1):47-53.
2001: H Fan; Ursula Scheffel; Paige A Rauseo; Y Xiao; A. Semih Dogan; Fuji Yokoi; John Hilton; K J Kellar; Dean F Wong; John L Musachio
[125/123I] 5-Iodo-3-pyridyl ethers. syntheses and binding to neuronal nicotinic acetylcholine receptors.
Nuclear medicine and biology 2001;28(8):911-21.
2001: Michael Kassiou; Stefan Eberl; Steven Meikle; Alex M Birrell; Chris J Constable; Michael J Fulham; Dean F Wong; John L Musachio
In vivo imaging of nicotinic receptor upregulation following chronic (-)-nicotine treatment in baboon using SPECT.
Nuclear medicine and biology 2001;28(2):165-75.
2000: Martin G Pomper; John L Musachio; Ursula Scheffel; JE MacDonald; Dennis J McCarthy; DW Reif; Victor L Villemagne; Fuji Yokoi; Robert F Dannals; Dean F Wong
Radiolabeled neuronal nitric oxide synthase inhibitors: synthesis, in vivo evaluation, and primate PET studies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(8):1417-25.
1999: Hayden T Ravert; William B Mathews; John L Musachio; Ursula Scheffel; PA Finley; Robert F Dannals
[11C]-methyl 4-[(3,4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl)-methyl]-1- piperazinecarboxylate ([11C]GR89696): synthesis and in vivo binding to kappa opiate receptors.
Nuclear medicine and biology 1999;26(7):737-41.
1999: John L Musachio; Victor L Villemagne; Ursula Scheffel; Robert F Dannals; A. Semih Dogan; Fuji Yokoi; Dean F Wong
Synthesis of an I-123 analog of A-85380 and preliminary SPECT imaging of nicotinic receptors in baboon.
Nuclear medicine and biology 1999;26(2):201-7.
1998: Andrew G Horti; Ursula Scheffel; Alane S Kimes; John L Musachio; Hayden T Ravert; William B Mathews; Y Zhan; PA Finley; Edythe D London; Robert F Dannals
Synthesis and evaluation of N-[11C]methylated analogues of epibatidine as tracers for positron emission tomographic studies of nicotinic acetylcholine receptors.
Journal of medicinal chemistry 1998;41(22):4199-206.
1998: Andrew G Horti; Ursula Scheffel; Andrei O KoreN; Hayden T Ravert; William B Mathews; John L Musachio; PA Finley; Edythe D London; Robert F Dannals
2-[18F]Fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors.
Nuclear medicine and biology 1998;25(7):599-603.
1998: T Mochizuki; Victor L Villemagne; Ursula Scheffel; Robert F Dannals; PA Finley; Y Zhan; Henry N Wagner; John L Musachio
Nicotine induced up-regulation of nicotinic receptors in CD-1 mice demonstrated with an in vivo radiotracer: gender differences.
Synapse (New York, N.Y.) 1998;30(1):116-8.
1998: Zsolt Szabo; PF Kao; H Donald Burns; Raymond E Gibson; Terence G Hamill; Hayden T Ravert; S E Kim; William B Mathews; John L Musachio; Ursula Scheffel; Robert F Dannals
Investigation of angiotensin II/AT1 receptors with carbon-11-L-159,884: a selective AT1 antagonist.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1998;39(7):1209-13.
1998: John R Lever; N Ilgìn; John L Musachio; Ursula Scheffel; PA Finley; John E Flesher; T K Natarajan; Henry N Wagner; J James Frost
Autoradiographic and SPECT imaging of cerebral opioid receptors with an iodine-123 labeled analogue of diprenorphine.
Synapse (New York, N.Y.) 1998;29(2):172-82.
1998: Michael Kassiou; Ursula Scheffel; Hayden T Ravert; William B Mathews; John L Musachio; Edythe D London; Robert F Dannals
Pharmacological evaluation of [11C]A-84543: an enantioselective ligand for in vivo studies of neuronal nicotinic acetylcholine receptors.
Life sciences 1998;63(1):PL13-8.
1998: John L Musachio; Ursula Scheffel; PA Finley; Y Zhan; T Mochizuki; Henry N Wagner; Robert F Dannals
5-[I-125/123]lodo-3(2(S)-azetidinylmethoxy)pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptors.
Life sciences 1998;62(22):PL 351-7.
1998: Victor L Villemagne; Jie Yuan; Dean F Wong; Robert F Dannals; George Hatzidimitriou; William B Mathews; Hayden T Ravert; John L Musachio; Una D McCann; George A Ricaurte
Brain dopamine neurotoxicity in baboons treated with doses of methamphetamine comparable to those recreationally abused by humans: evidence from [11C]WIN-35,428 positron emission tomography studies and direct in vitro determinations.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(1):419-27.
1997: X Liu; John L Musachio; Henry N Wagner; T Mochizuki; Robert F Dannals; Edythe D London
External monitoring of cerebral nicotinic acetylcholine receptors in living mice.
Synapse (New York, N.Y.) 1997;27(4):378-80.
1997: T Mochizuki; Victor L Villemagne; Ursula Scheffel; X Liu; John L Musachio; Robert F Dannals; Henry N Wagner
A simple probe measures the pharmacokinetics of[125I]RTI-55 in mouse brain in vivo.
European journal of pharmacology 1997;338(1):17-23.
1997: John L Musachio; Victor L Villemagne; Ursula Scheffel; M Stathis; PA Finley; Andrew G Horti; Edythe D London; Robert F Dannals
[125/123I]IPH: a radioiodinated analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors.
Synapse (New York, N.Y.) 1997;26(4):392-9.
1997: Martha I Dávila-García; John L Musachio; David C Perry; Yingxian Xiao; Andrew G Horti; E D London; Robert F Dannals; Kenneth J Kellar
[125I]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors.
The Journal of pharmacology and experimental therapeutics 1997;282(1):445-51.
1997: Igal Madar; Ronald P Lesser; Gregory Krauss; Jon K Zubieta; John R Lever; C M Kinter; Hayden T Ravert; John L Musachio; William B Mathews; Robert F Dannals; J James Frost
Imaging of delta- and mu-opioid receptors in temporal lobe epilepsy by positron emission tomography.
Annals of neurology 1997;41(3):358-67.
1996: Igal Madar; John R Lever; C M Kinter; Ursula Scheffel; Hayden T Ravert; John L Musachio; William B Mathews; Robert F Dannals; J James Frost
Imaging of delta opioid receptors in human brain by N1'-([11C]methyl)naltrindole and PET.
Synapse (New York, N.Y.) 1996;24(1):19-28.
1996: Terence G Hamill; H Donald Burns; Robert F Dannals; William B Mathews; John L Musachio; Hayden T Ravert; E M Naylor
Development of [11C]L-159,884: a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1996;47(2):211-8.
1996: Zsolt Szabo; PF Kao; William B Mathews; Hayden T Ravert; John L Musachio; Ursula Scheffel; Robert F Dannals
Positron emission tomography of 5-HT reuptake sites in the human brain with C-11 McN5652 extraction of characteristic images by artificial neural network analysis.
Behavioural brain research 1996;73(1-2):221-4.
1996: John L Musachio; K I Keverline; Frank carroll; Robert F Dannals
3 Beta-(p-trimethylsilylphenyl)tropane-2 beta-carboxylic acid methyl ester: a new precursor for the preparation of [123I]RTI-55.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1996;47(1):79-81.
1995: Mian M Alauddin; Hayden T Ravert; John L Musachio; William B Mathews; Robert F Dannals; Peter S Conti
Selective alkylation of pyrimidyl dianions III: no-carrier-added synthesis of [11C-methyl]-thymidine.
Nuclear medicine and biology 1995;22(6):791-4.
1995: Zsolt Szabo; PF Kao; Ursula Scheffel; M Suehiro; William B Mathews; Hayden T Ravert; John L Musachio; S Marenco; Sang Eun Kim; George A Ricaurte
Positron emission tomography imaging of serotonin transporters in the human brain using [11C](+)McN5652.
Synapse (New York, N.Y.) 1995;20(1):37-43.
1995: M Suehiro; John L Musachio; Robert F Dannals; William B Mathews; Hayden T Ravert; Ursula Scheffel; Henry N Wagner
An improved method for the synthesis of radiolabeled McN5652 via thioester precursors.
Nuclear medicine and biology 1995;22(4):543-5.
1995: Michael Kassiou; Ursula Scheffel; Hayden T Ravert; William B Mathews; John L Musachio; R M Lambrecht; Robert F Dannals
[11C]A-69024: a potent and selective non-benzazepine radiotracer for in vivo studies of dopamine D1 receptors.
Nuclear medicine and biology 1995;22(2):221-6.
1995: Michael Kassiou; Ursula Scheffel; John L Musachio; M Stathis; Robert F Dannals
[3H]A-69024: a non-benzazepine ligand for in vitro and in vivo studies of dopamine D1 receptors.
Life sciences 1995;57(23):PL367-72.
1994: John L Musachio; Ursula Scheffel; M Stathis; Hayden T Ravert; William B Mathews; Robert F Dannals
(+)-[C-11]-cis-N-benzyl-normetazocine: a selective ligand for sigma receptors in vivo.
Life sciences 1994;55(11):PL225-32.
1992: John L Musachio; John R Lever
Vinylstannylated alkylating agents as prosthetic groups for radioiodination of small molecules: design, synthesis, and application to iodoallyl analogues of spiperone and diprenorphine.
Bioconjugate chemistry 1992;3(2):167-75.
1991: John R Lever; Ursula Scheffel; John L Musachio; M Stathis; Henry N Wagner
Radioiodinated D-(+)-N1-ethyl-2-iodolysergic acid diethylamide: a ligand for in vitro and in vivo studies of serotonin receptors.
Life sciences 1991;48(15):PL73-8.
1990: John R Lever; Ursula Scheffel; M Stathis; John L Musachio; Henry N Wagner
In vitro and in vivo binding of (E)- and (Z)-N-(iodoallyl)spiperone to dopamine D2 and serotonin 5-HT2 neuroreceptors.
Life sciences 1990;46(26):1967-76.